Hub : Genes

Sox10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Sox10	0.07	0.05	9.7e-03	0.02	0.02	0	0	7.1e-02	6.0e-02	2.0e-01	2.0e-01
2	NAcc	gene expression	Sox10	0.04	0.02	2.2e-06	0.04	0.03	0.03	0.03	3.0e-06	2.0e-05	9.9e-06	1.1e-05
3	PL	gene expression	Sox10	0.05	0.03	1.0e-03	0.03	0.02	0.01	0.03	6.0e-04	1.5e-03	9.2e-03	8.6e-04
4	BLA	gene expression	Sox10	0.13	0.06	1.0e-05	0.06	0.05	0.06	0.04	7.3e-04	1.0e-03	3.5e-04	1.9e-03
5	pVTA	gene expression	Sox10	0.04	0.03	8.7e-03	0	0	0	0.01	2.5e-01	1.3e-01	1.5e-01	8.8e-02
6	Brain	gene expression	Sox10	0.09	0.04	8.6e-08	0.05	0.08	0.07	0.07	9.1e-06	1.4e-07	1.6e-07	2.9e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.3	-0.3	-0.1	-0.1	-0.5	-0.1	-0.3
Area under the delay curve	2.5	3.9	5.8	2.0	-1.9	-1.7	-2.1	2.4	1.6
BMI with tail	0.5	1.6	4.9	-2.2	0.8	0.8	-0.0	-1.2	-1.4
BMI without tail	0.5	2.6	4.4	-2.1	0.8	1.0	0.9	-2.0	-2.1
Body weight	2.2	9.6	15.2	-3.9	3.2	2.6	2.4	-3.3	-3.0
Weight adjusted by age	0.3	0.8	1.5	-0.9	0.8	1.2	1.2	-0.2	-0.4
Bone surface	0.1	0.2	0.6	0.7	-0.1	0.1	-0.0	0.5	0.8
Bone volume	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.3	0.1	0.1
Breakpoint value in progressive ratio session	0.1	0.3	0.6	0.2	-0.5	-0.4	-0.8	0.6	0.2
Number of licking bursts	0.2	0.7	1.7	1.2	-1.3	-0.9	-0.5	0.2	0.2
Context. condit. distance diff. score	3.6	4.4	6.7	-2.5	2.6	1.8	1.9	-2.1	-1.4
Locomotion velocity, session 1	0.8	0.9	2.3	0.3	0.9	1.3	1.5	0.4	0.7
Locomotion distance, session 1	4.0	5.2	10.4	3.2	-2.1	-1.4	-1.0	2.6	2.6
Locomotion velocity, session 2	0.8	1.0	3.5	0.7	0.1	0.4	-0.2	1.4	1.9
Locomotion distance, session 2	4.2	5.9	11.4	3.4	-2.2	-1.8	-1.4	2.7	2.6
Locomotion velocity, session 3	0.7	0.8	2.6	-0.1	0.9	0.9	1.6	-0.5	0.3
Locomotion distance, session 3	1.0	1.1	2.6	1.6	-1.5	-1.2	-0.2	0.3	0.6
Stereotopy head waving bouts, day 3	0.8	1.0	2.2	-1.0	1.5	1.2	0.9	-0.6	-0.5
Stereotopy head waving duration, day 3	3.3	4.1	7.2	-2.3	2.7	2.6	1.8	-1.2	-0.8
Locomotion velocity, session 7	0.9	1.0	1.6	-1.0	0.2	1.3	1.1	-1.0	-0.9
Locomotion distance, session 7	0.8	1.0	2.1	-0.6	0.5	0.9	1.4	-1.0	-1.2
Stereotopy head waving bouts, day 7	2.2	2.6	5.7	-1.8	1.9	2.4	1.5	-0.5	0.1
Stereotopy head waving duration, day 7	1.6	1.9	4.5	-1.8	1.7	2.1	1.0	-0.1	0.4
Locomotion velocity, session 8	1.6	1.9	3.8	-0.8	1.9	2.0	1.9	-0.2	0.4
Locomotion distance, session 8	0.2	0.4	0.7	-0.4	0.8	0.8	0.7	0.0	0.4
Degree of sensitization distance	4.9	5.3	8.0	-2.8	2.6	2.5	1.9	-1.7	-2.1
Degree of sensitization stereotypy	1.5	1.7	4.6	-1.2	1.5	2.1	1.2	0.3	0.9
Conditioned locomotion	1.3	1.6	2.4	-1.3	1.0	1.5	1.4	-1.2	-0.9
Cocaine response after cond. corrected	0.2	0.3	0.8	-0.3	0.6	0.9	0.4	0.3	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.2	0.2	0.5	-0.2	0.4	0.6
Cocaine response before conditioning	0.6	0.8	1.9	0.6	-1.4	-1.1	-1.1	0.2	0.2
Saline control response	0.2	0.3	0.8	-0.2	0.9	0.3	0.7	-0.6	-0.1
Bone: connectivity density	0.2	0.3	0.5	-0.5	0.5	0.5	0.6	-0.7	-0.5
Bone: cortical apparent density	0.4	0.6	1.9	-0.1	-0.4	-0.8	0.2	-1.4	-1.0
Bone: cortical area	0.2	0.4	0.9	-0.5	0.8	1.0	0.4	-0.4	-0.1
Bone: cortical porosity	0.2	0.3	0.9	-0.3	0.9	0.5	-0.2	0.4	0.5
Bone: cortical porosity	0.7	0.8	2.0	-0.5	1.4	1.2	0.5	0.3	0.7
Bone: cortical thickness	0.5	0.8	1.5	1.1	-0.9	-1.2	-1.2	0.3	0.3
Bone: cortical thickness	1.1	1.3	2.0	1.4	-1.4	-1.3	-1.3	0.8	0.7
Bone: cortical tissue density	0.4	0.6	1.8	-0.1	-0.4	-0.7	0.3	-1.4	-1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	-0.3	-0.4	0.3	-0.7	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.1	0.1	0.1	0.8	-0.9	-0.6
Condit. Reinf. active responses	0.5	0.6	1.5	0.2	-0.6	-1.1	-0.2	-0.9	-1.2
Condit. Reinf. inactive responses	0.7	0.9	1.9	-0.1	-0.7	-1.4	-0.8	-0.6	-1.3
Incentive salience index mean	0.5	0.7	1.9	0.0	-0.6	-0.5	0.4	-1.2	-1.4
Condit. Reinf. lever presses	0.8	1.2	3.5	-0.4	-0.9	-0.6	0.2	-1.6	-1.9
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	0.8	-0.2	-0.3	-0.4	1.0	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.0	0.4	0.4	0.1	0.4	0.2
Condit. Reinf. active responses	0.5	0.8	2.0	0.9	-0.1	-0.1	-0.3	1.4	1.3
Condit. Reinf. inactive responses	0.6	0.9	1.8	1.4	-0.6	-0.4	-0.2	1.2	1.3
Condit. Reinf. lever presses	0.3	0.4	0.8	0.5	-0.9	-0.7	-0.8	0.5	0.1
Condit. Reinf. lever reinforcers received	0.3	0.4	1.3	0.6	0.1	0.1	-0.1	1.2	1.0
Conditioned reinforcement - actives	0.9	3.7	7.4	2.7	-1.5	-2.0	-1.6	1.5	1.8
Conditioned reinforcement - inactives	1.2	3.2	6.0	2.2	-1.9	-2.4	-1.8	1.1	0.6
Conditioned locomotion	1.4	2.1	3.0	1.7	-0.5	-1.5	-1.7	1.4	1.7
Patch foraging indifference point 0 sec	0.4	1.2	3.0	-0.5	0.7	0.4	1.2	-1.7	-1.3
Patch foraging indifference point AUC	0.6	1.4	4.8	2.2	-1.3	-1.1	-0.1	0.6	0.7
Delay disc. indifference point, 0s delay	0.3	0.3	1.3	-0.5	0.2	-0.5	-1.2	0.3	-0.1
Delay disc. indifference point, 16s delay	2.8	3.9	5.9	2.1	-1.9	-1.6	-1.9	2.4	1.7
Delay disc. indifference point, 2s delay	9.7	10.8	15.9	2.9	-2.7	-2.8	-4.0	3.8	3.3
Delay disc. indifference point, 24s delay	0.3	0.5	1.6	1.1	-0.3	0.4	1.3	-0.1	0.2
Delay disc. indifference point, 4s delay	2.1	2.2	4.7	1.2	-1.1	-0.9	-1.7	2.2	1.5
Delay disc. indifference point, 8s delay	0.9	1.5	2.5	1.4	-1.6	-1.5	-1.1	1.0	0.3
Indifference point function ln k	0.6	1.9	4.4	-2.1	1.6	1.4	0.8	-1.1	-0.7
Indifference point function log k	0.6	1.9	4.4	-2.1	1.6	1.4	0.8	-1.1	-0.7
Patch foraging total patch changes 0 sec	0.2	0.6	1.9	-0.1	0.2	-0.2	0.7	-1.4	-1.0
Patch foraging total patch changes 12 sec	0.2	0.3	1.0	1.0	0.1	-0.1	0.6	-0.3	0.3
Patch foraging total patch changes 18 sec	0.1	0.3	0.8	0.9	-0.2	-0.3	0.4	-0.7	-0.4
Patch foraging total patch changes 24 sec	0.2	0.7	1.2	1.1	-0.9	-1.1	0.1	-0.7	-0.6
Patch foraging total patch changes 6 sec	0.2	0.3	0.9	0.9	-0.4	-0.5	0.3	-0.4	-0.2
Patch foraging time to switch 0 sec	0.2	0.6	1.4	-0.6	0.2	0.4	-1.1	1.2	0.9
Patch foraging water rate 0 sec	0.8	3.0	6.3	-1.0	0.9	0.7	2.0	-2.5	-2.4
Patch foraging water rate 12 sec	0.2	0.7	2.0	-0.5	-0.1	0.1	0.6	-1.4	-1.2
Patch foraging water rate 18 sec	0.9	2.1	4.9	-0.5	0.7	1.0	2.2	-1.9	-1.6
Patch foraging water rate 24 sec	2.8	4.0	5.5	-2.0	2.0	1.8	2.2	-2.3	-1.7
Patch foraging water rate 6 sec	0.9	1.3	3.7	-0.6	-0.2	-0.3	0.7	-1.8	-1.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.9	0.3	-0.6	-0.2	-0.7	1.0	0.6
Distance traveled before self-admin	0.6	1.4	2.7	0.8	-0.6	-0.8	-1.6	1.7	1.2
Distance traveled after self-admin	0.3	0.6	1.3	-0.2	0.7	0.7	1.2	-0.7	-0.8
Extensor digitorum longus weight	0.9	3.6	10.5	0.6	-1.9	-1.9	-3.2	1.7	0.9
Bone: elastic displacement	0.8	1.0	1.9	-1.3	0.9	1.4	1.0	-0.5	-0.5
Bone: elastic work	1.9	2.5	6.4	-1.8	1.8	2.5	1.4	-0.4	-0.3
Bone: endosteal estimation	1.0	2.5	5.5	-1.2	2.1	2.3	1.9	-0.3	0.1
Bone: endosteal perimeter	1.0	2.5	6.3	-1.5	1.9	2.5	1.6	-0.5	0.0
Epididymis fat weight	1.0	5.0	8.3	-2.8	2.9	1.8	1.7	-2.2	-1.6
Delta time in closed arm before/after self-admin	1.0	0.9	1.7	1.2	-0.7	-1.3	-1.1	0.4	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.2	0.4	0.1	0.5	0.2
Diff in mean of infusions in LGA sessions	0.2	0.4	1.2	-0.1	0.5	0.7	1.1	-0.2	-0.5
Delay discount exponential model param	2.8	3.8	5.6	-2.0	1.9	1.7	2.0	-2.4	-1.6
Extinction: sum of active levers before priming	1.1	1.6	3.3	1.3	-0.8	-0.3	-1.1	1.8	1.7
Active lever presses in extinction session 6	0.1	0.1	0.3	0.1	0.0	0.3	-0.3	0.5	0.5
Bone: final force	0.4	0.6	2.2	-0.5	0.9	1.5	0.7	-0.0	0.2
Bone: final moment	0.6	0.9	2.8	-0.7	1.1	1.7	0.9	-0.2	0.1
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.5	0.2	-0.0	-0.1	0.4	0.6
Glucose	0.6	1.0	2.8	-0.9	0.4	-0.3	-0.1	-1.4	-1.7
Heart weight	4.2	6.7	10.8	-2.6	2.8	3.3	3.0	-2.0	-1.5
Delay discount hyperbolic model param	3.8	4.9	7.1	-2.2	2.1	2.0	2.4	-2.7	-1.9
Intermittent access intake day 1-15 change	0.0	0.3	0.7	0.5	-0.4	-0.8	-0.6	-0.1	0.2
Intermittent access intake escalation	0.0	0.3	0.6	0.6	-0.6	-0.8	-0.5	-0.1	0.2
Intermittent access intake escalation 2	0.1	0.2	0.4	0.1	-0.4	-0.6	-0.2	-0.6	-0.4
Intermitt. access day 1 inactive lever presses	0.1	1.7	2.5	-1.0	1.1	1.2	1.6	-1.3	-1.5
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.4	0.1	0.0	-0.0	0.4	-0.2	-0.6
Intermitt. access escalation Index	0.4	1.3	2.4	1.1	-1.6	-1.4	-1.2	0.7	0.6
Intermittent access day 1 total infusions	1.2	3.6	7.5	2.7	-1.0	-1.3	-1.3	2.0	2.4
Intermittent access day 15 total infusions	1.3	3.2	6.2	2.5	-1.3	-1.6	-1.5	1.6	1.9
Intermittent access terminal intake (last 3 days)	1.6	2.8	5.9	2.4	-1.2	-1.2	-1.1	1.7	2.0
Intermittent access total infusions	3.8	4.5	8.6	2.9	-1.4	-1.6	-1.7	2.2	2.5
Intermittent access day 1 locomotion	0.7	1.2	2.6	1.6	-0.9	-1.0	-1.0	1.0	1.0
Intermittent access day 15 total locomotion	0.1	0.5	1.3	1.1	-0.3	-0.8	-0.6	0.3	0.5
Intermittent access total locomotion	0.2	0.2	0.6	0.8	-0.1	-0.7	-0.3	-0.2	-0.1
Intermittent access standard deviation	0.0	0.1	0.5	0.2	0.7	0.0	-0.1	-0.1	-0.1
Left kidney weight	2.3	18.7	39.3	-4.1	6.3	5.6	4.5	-2.0	-0.9
Right kidney weight	3.7	26.1	50.2	-5.3	7.1	5.9	5.2	-3.3	-2.3
Cocaine induced anxiety	0.1	0.2	0.6	-0.8	0.7	0.2	-0.2	0.1	-0.1
Post-drug Anxiety	1.3	1.5	4.1	-2.0	0.9	0.8	0.4	-1.0	-1.5
Baseline Anxiety	0.1	0.2	0.4	-0.1	-0.6	-0.0	0.1	-0.5	-0.6
Tail length	0.6	3.4	6.8	-1.7	1.2	0.8	1.7	-2.6	-2.4
Length with tail	1.9	8.5	10.9	-2.9	3.1	2.5	3.0	-3.3	-2.6
Length without tail	1.5	7.7	13.8	-2.7	3.7	3.1	2.9	-2.1	-1.5
Times rat made contact with spout	1.0	1.2	2.3	1.1	-0.9	-0.9	0.8	-1.5	-1.2
Lifetime Intake	3.6	4.5	8.8	3.0	-1.3	-1.6	-1.7	2.3	2.5
Liver weight, left	0.0	0.1	0.2	-0.0	0.4	-0.1	0.1	-0.0	0.3
Liver weight, right	1.5	2.7	4.0	-1.9	1.8	1.2	1.6	-2.0	-1.2
Locomotor activity	0.7	1.1	2.5	-1.0	1.6	0.9	1.1	-1.0	-0.4
Locomotor testing distance	0.1	0.2	0.6	0.2	-0.2	-0.8	-0.2	-0.6	-0.4
Locomotor testing rearing	0.1	0.2	0.7	0.0	0.8	0.3	0.5	-0.5	0.3
Locomotion in novel chamber	0.9	1.3	2.9	0.6	-1.7	-1.5	-1.4	0.3	0.1
Locomotion in novel chamber post-restriction	1.0	3.2	4.3	1.6	-2.1	-2.0	-2.1	1.6	1.2
Fecal boli incidents, locomotor time 1	0.2	0.5	1.6	0.4	0.2	0.8	1.3	-0.6	-0.6
Change in fecal boli incidents, locomotor task	0.6	0.7	2.1	-0.3	0.7	0.5	1.5	-0.9	-0.3
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.5	-0.7	1.2	1.1	0.8	-0.6	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.1	0.4	0.3	0.3	-0.5	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.3	0.4	0.5	0.4	-0.5	-0.4
Rest time, locomotor task time 1	0.6	0.9	1.5	-0.7	0.7	0.9	1.2	-1.0	-1.1
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.4	0.5	0.3	0.2	0.0	0.4
Vertical activity count, locomotor time 1	0.3	1.8	3.8	-1.4	0.9	0.1	0.8	-1.9	-1.9
Time >=10cm from walls, locomotor time 2	0.9	2.6	3.7	-1.3	0.9	1.8	1.9	-1.9	-1.5
Bouts of movement, locomotor time 2	0.9	3.1	6.7	1.2	-1.5	-1.8	-2.6	1.7	1.5
Total resting periods, locomotor time 2	1.0	4.0	7.6	1.5	-1.7	-1.9	-2.7	2.1	1.8
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	-0.2	-0.0	0.2	0.1	-0.1
Distance moved, locomotor task time 2	0.8	1.1	1.5	-1.2	1.0	1.2	1.2	-0.9	-0.8
Vertical activity count, locomotor time 2	1.0	2.4	3.9	-1.5	1.0	0.9	1.6	-2.0	-2.0
Light reinforcement 1	0.0	0.0	0.2	0.2	-0.0	0.2	0.0	0.2	0.4
Light reinforcement 2	0.1	0.2	0.5	-0.2	0.2	-0.0	-0.6	0.4	0.7
Bone: marrow area	1.1	2.7	5.9	-1.2	2.2	2.4	2.0	-0.3	0.1
Bone: maximum diameter	1.6	3.1	6.7	-1.6	2.6	2.5	1.7	-0.7	-0.2
Bone: maximum force	0.4	0.7	2.4	-0.4	1.1	1.5	0.8	-0.1	0.2
Bone: maximum moment	0.6	1.1	3.0	-0.6	1.4	1.7	1.0	-0.2	0.2
Mean time between licks in bursts	0.2	1.2	2.8	0.2	-0.8	0.1	-1.4	1.7	1.4
Mean num. licks in bursts	0.2	0.7	1.4	-0.3	0.7	0.2	1.1	-1.2	-0.8
Cd content in liver	0.2	0.2	0.7	0.6	-0.2	-0.4	-0.1	0.1	0.8
Co content in liver	0.5	0.6	1.3	0.7	-1.1	-0.9	-1.0	0.3	0.2
Cu content in liver	1.9	2.2	4.4	1.6	-2.1	-1.9	-1.5	0.7	0.2
Fe content in liver	3.9	4.9	9.4	-2.4	3.1	2.8	1.9	-1.2	-0.9
K content in liver	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.1	-0.2
Mg content in liver	0.1	0.1	0.2	0.3	0.2	0.0	0.4	-0.3	-0.2
Mn content in liver	0.6	0.6	1.0	1.0	-0.7	-0.9	-0.6	0.7	0.7
Na content in liver	0.3	0.4	1.0	-0.6	0.3	0.3	0.5	-0.8	-1.0
Rb content in liver	0.0	0.0	0.1	0.3	0.2	0.2	0.1	-0.1	0.0
Se content in liver	0.4	0.5	0.7	0.5	-0.8	-0.8	-0.7	0.6	0.7
Sr content in liver	3.6	3.1	7.0	1.2	-2.7	-2.3	-2.0	0.8	0.0
Zn content in liver	0.1	0.1	0.4	0.7	-0.3	-0.5	0.1	-0.2	0.1
Bone: minimum diameter	0.1	0.3	0.8	-0.1	0.9	0.7	0.5	0.2	0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.8	-0.1	-0.4	0.9	0.6	-0.1	-0.0
Time in novel zone, hab. session 1	0.3	0.3	1.2	-0.6	1.1	0.2	0.2	-0.3	-0.0
Total zone transitions, hab. session 1	2.0	2.7	4.1	1.9	-2.0	-1.9	-1.3	1.3	1.2
Total locomotion distance, hab. session 1	0.6	0.9	1.6	1.2	-1.1	-1.3	-0.6	0.4	0.6
Locomotion velocity, hab. session 1	0.8	1.1	2.1	1.3	-1.2	-1.4	-0.8	0.5	0.6
Time in familiar zone, hab. session 2	0.1	0.1	0.7	0.1	-0.8	-0.1	-0.2	-0.2	0.0
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	0.6	-0.6	-0.3	0.3	0.1
Total zone transitions, hab. session 2	0.5	0.7	2.5	1.6	-0.9	-0.6	0.4	0.5	0.4
Total locomotion distance, hab. session 2	0.5	0.6	1.7	1.3	-0.5	-0.4	-0.1	1.0	0.9
Locomotion velocity, hab. session 2	0.4	0.5	1.6	1.3	-0.7	-0.3	0.0	0.8	0.6
Novel to familiar place preference ratio	0.7	0.9	2.7	-0.9	1.6	0.9	1.0	-0.7	-0.0
Novelty place preference	0.8	1.0	2.9	-0.9	1.7	0.8	1.0	-0.9	-0.1
Time in novel zone, NPP test	1.0	1.2	3.3	-1.0	1.8	0.8	1.1	-1.0	-0.2
Total zone transitions, NPP test	1.6	2.3	4.9	2.2	-1.9	-1.5	-0.7	1.1	1.1
Total locomotion distance, NPP test	0.4	0.6	1.6	1.3	-0.7	-0.2	0.3	0.8	0.8
Locomotion velocity, NPP test	0.7	1.0	2.3	1.5	-1.2	-0.6	-0.1	1.0	0.9
Intraocular pressure	0.2	0.3	0.8	-0.2	0.9	0.8	0.6	-0.1	0.5
Delta distance traveled before/after self-admin	3.9	4.3	9.1	-1.1	1.7	1.7	3.0	-2.4	-1.9
Delta ambulatory time before/after self-admin	2.3	4.0	9.8	-0.8	1.7	1.9	3.1	-2.1	-1.5
Parametrial fat weight	1.3	3.2	6.4	-2.1	0.6	0.6	0.9	-2.5	-2.5
Pavlov. Cond. lever latency	0.1	0.1	0.5	-0.1	0.7	0.2	0.3	0.1	0.3
Pavlov. Cond. magazine entry latency	1.1	1.5	2.8	1.0	-1.7	-0.8	-1.4	1.3	0.9
Pavlov. Cond. change in total contacts	1.8	2.0	3.4	1.8	-1.6	-1.2	-1.2	1.4	1.1
Pavlov. Cond. index score	0.3	0.3	1.2	0.6	-1.1	-0.3	-0.4	0.4	0.1
Pavlov. Cond. latency score	0.2	0.2	0.8	0.3	-0.9	-0.3	-0.5	0.3	0.0
Pavlov. Cond. lever contacts	0.3	0.4	1.4	0.3	-1.2	-0.5	-0.5	-0.0	-0.4
Pavlov. Cond. magazine entry number	1.1	1.4	2.8	-1.4	1.7	1.0	1.0	-1.0	-0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.5	-0.1	0.4	-0.2	0.7	-1.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.5	0.7	-1.2	-0.5	-0.6	0.5	0.2
Pavlov. Cond. response bias	0.6	0.8	2.3	0.9	-1.5	-0.7	-0.8	0.6	0.2
Pavlov. Cond. lever latency	0.3	0.5	1.1	1.0	-0.1	-0.6	-0.3	0.6	1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	0.6	-0.6	-0.9	-0.8	0.3	-0.4
Pavlov. Cond. change in total contacts	1.3	3.2	5.2	-2.1	1.6	2.3	1.7	-1.3	-1.7
Pavlov. Cond. index score	0.2	0.3	1.3	-0.6	0.1	0.3	0.3	-0.5	-1.1
Pavlov. Cond. latency score	0.3	0.4	1.6	-0.6	0.0	0.3	0.3	-0.6	-1.3
Pavlov. Cond. lever contacts	0.4	0.5	1.3	-0.9	0.1	0.5	0.4	-0.7	-1.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.8	0.4	-0.2	-0.2	-0.1	0.3	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.1	0.2	0.1	0.6	-0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.1	-0.7	0.1	0.3	0.1	-0.4	-1.0
Pavlov. Cond. response bias	0.1	0.2	0.6	-0.6	0.1	0.5	0.1	-0.2	-0.8
Time in closed arm before self-admin	0.2	0.3	0.7	-0.4	-0.5	-0.7	-0.7	-0.1	-0.8
Time in closed arm after self-admin	0.4	0.5	1.4	-0.2	0.1	-0.6	0.1	-1.2	-1.1
Time in open arm before self-admin	0.3	0.4	1.1	-0.2	0.1	0.5	1.0	-0.7	-0.5
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	-0.4	0.1	-0.1	0.2	0.1
Bone: periosteal estimation	0.8	1.9	4.6	-1.0	1.9	2.1	1.5	-0.3	0.1
Bone: periosteal perimeter	1.8	3.6	7.7	-1.6	2.4	2.8	2.2	-1.0	-0.3
Bone: post-yield work	0.2	0.3	0.7	0.8	-0.2	0.3	0.2	0.6	0.8
Progressive ratio test 1 active lever presses	1.7	3.0	5.9	2.4	-1.0	-1.2	-1.3	1.9	2.2
Progressive ratio test 1 breakpoint	1.6	2.8	5.7	2.4	-1.0	-1.1	-1.2	1.8	2.1
Progressive ratio test 1 inactive lever presses	0.8	2.1	3.3	1.4	-1.0	-1.3	-1.8	1.7	1.3
Progressive ratio test 2 active lever presses	2.5	3.6	7.6	2.8	-1.5	-2.0	-1.6	1.5	1.7
Progressive ratio test 2 breakpoint	3.2	4.1	8.2	2.9	-1.7	-2.0	-1.8	1.7	1.9
Progressive ratio test 2 inactive lever presses	1.3	4.1	7.3	2.7	-2.2	-2.4	-1.8	1.4	1.2
Incentive Sensitization - Responses	0.4	1.2	2.1	1.5	-1.1	-1.4	-1.0	0.5	0.6
Incentive Sensitization - Breakpoint	0.5	1.2	2.1	1.5	-1.1	-1.4	-1.1	0.5	0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.6	0.1	0.2	-0.2	0.0	-0.3
Progressive ratio	0.0	0.1	0.2	-0.0	0.5	0.1	-0.1	0.4	0.2
Food seeking constrained by brief footshock	0.4	0.4	1.2	0.8	-0.2	-0.3	-0.6	0.6	1.1
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.1	-0.1	0.2
Retroperitoneal fat weight	1.9	8.6	15.5	-3.9	3.5	3.0	2.0	-2.5	-2.0
Reaction time number correct	0.3	1.2	2.3	1.5	-1.4	-1.0	-0.4	0.7	1.0
Reaction time mean minus median	0.0	0.0	0.1	-0.3	0.2	0.2	-0.0	0.2	-0.0
Reaction time mean minus median AUC	0.0	0.2	0.5	-0.7	0.7	0.3	0.2	-0.3	-0.4
Reaction time num false alarms	0.0	0.0	0.2	0.0	0.2	-0.2	-0.0	-0.4	-0.0
Reaction time num false alarms AUC	0.0	0.1	0.1	0.2	0.2	-0.3	-0.0	-0.3	0.2
Reaction time trials correct on left	0.3	1.2	2.3	1.5	-1.4	-1.0	-0.4	0.7	1.0
Reaction time trials on left	0.4	1.4	2.7	1.6	-1.5	-1.1	-0.6	0.8	1.2
Reaction time mean	0.3	0.6	1.6	-1.3	0.7	0.8	0.4	-0.5	-0.8
Reaction time mean AUC	0.1	0.3	0.8	-0.9	0.6	0.5	0.3	-0.4	-0.6
Median of all reaction times	0.4	0.6	1.6	-1.2	0.7	0.8	0.4	-0.5	-0.7
Reaction time omissions	2.8	4.5	6.1	1.9	-1.8	-1.7	-2.5	2.4	2.3
Reaction time false alarm rate	0.1	0.2	0.5	-0.5	0.7	0.0	-0.1	-0.5	-0.4
Reaction time premature initiation rate	0.1	0.2	0.4	-0.2	0.7	0.4	0.4	0.0	-0.3
Reaction time premature initiations	0.0	0.1	0.2	0.5	0.1	-0.1	0.3	0.2	0.1
Std. dev. reaction times	0.1	0.4	0.7	-0.9	0.8	0.5	0.4	-0.5	-0.5
Reaction time trials completed	0.4	1.4	2.7	1.6	-1.5	-1.1	-0.6	0.8	1.2
Reaction time trials AUC	0.3	1.0	2.1	1.5	-1.2	-0.9	-0.4	0.7	1.1
Run reversals in cocaine runway, females	0.6	0.7	1.5	-0.9	0.3	0.8	0.7	-1.2	-0.9
Run reversals in cocaine runway, males	0.7	0.8	2.0	0.9	0.9	0.6	1.4	0.4	0.8
Latency to leave start box in cocaine runway	0.4	0.5	1.0	-0.6	0.6	0.8	-0.3	0.9	1.0
Latency to leave start box in cocaine runway, F	0.3	0.4	0.9	-0.4	0.1	0.8	-0.2	0.8	0.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.6	0.7	0.2	-0.1	0.2	0.3
Std. dev. time between licks in bursts	0.1	0.2	0.6	-0.3	0.4	0.8	0.5	-0.1	-0.2
Total sessions with >9 infusions	0.9	1.1	2.6	1.4	0.1	-0.0	-0.3	1.4	1.6
Short access day 1 total inactive lever presses	0.6	1.1	2.5	-0.4	1.6	1.3	1.5	-0.2	-0.4
Short access day 10 total inactive lever presses	0.8	5.4	8.7	-1.7	1.6	1.7	2.9	-2.7	-2.7
Short access day 1 total infusions	0.1	0.2	0.5	0.4	0.4	0.4	0.7	0.2	0.1
Short access day 10 total infusions	0.8	1.3	3.3	1.6	0.0	-0.3	-0.4	1.3	1.8
Short access total infusions	1.3	1.8	3.9	2.0	-0.3	-0.5	-0.6	1.7	1.9
Short access day 1 locomotion	0.1	0.2	0.5	0.2	0.7	0.2	0.6	-0.2	-0.1
Short access day 10 total locomotion	0.1	0.6	2.3	-0.2	0.0	-0.3	0.2	-1.0	-1.5
Short access total locomotion	0.0	0.0	0.1	0.3	0.2	-0.3	-0.2	0.1	-0.1
One hour access (0.3 mA shock)	7.9	9.3	16.5	4.1	-3.0	-3.1	-2.7	2.6	2.7
Compulsive drug intake	0.3	0.5	1.3	0.7	-1.1	-0.8	-0.1	0.2	-0.5
One hour access (shock baseline)	1.4	3.7	5.2	2.2	-1.4	-1.7	-2.0	1.8	2.3
Social response proportion	1.0	1.2	2.8	-0.5	0.3	0.7	-1.1	1.7	1.5
Social responses	0.6	0.8	1.7	0.9	-0.3	-0.3	-0.7	1.3	1.3
Social time	1.1	1.8	2.6	1.5	-1.6	-1.3	-1.5	1.1	0.9
Soleus weight	0.6	1.7	5.0	-0.1	-1.0	-1.0	0.1	-1.7	-2.2
Bone: stiffness	0.7	1.2	2.5	-1.1	1.3	1.6	0.9	-0.8	-0.6
Tibialis anterior weight	2.4	8.3	15.1	2.4	-3.1	-3.6	-3.9	2.2	1.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.2	-0.0	-0.6	-0.6	0.7	0.4
Time to tail flick, vehicle, after self-admin	0.8	1.7	2.8	-1.1	0.9	0.7	1.4	-1.6	-1.7
Time to tail flick, test, before self-admin	1.4	1.6	2.1	1.4	-1.1	-1.5	-1.3	1.1	1.2
Time to tail flick, test, after self-admin	0.2	0.2	0.5	-0.1	-0.5	0.0	0.3	-0.7	-0.6
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.1	-0.4	0.8	1.1	1.1	-0.6	-0.5
Delta time to tail flick, test, before/after SA	0.4	0.5	1.4	-0.6	-0.5	-0.1	-0.1	-1.0	-1.2
Tibia length	0.3	0.9	1.9	-0.7	1.3	1.4	1.0	-0.5	-0.1
Ambulatory time before self-admin	0.4	1.2	2.2	0.9	-0.8	-1.1	-1.5	1.2	0.8
Ambulatory time after self-admin	0.3	0.5	1.3	0.1	0.3	0.4	1.1	-1.1	-0.7
Bone: tissue strength	0.4	0.4	1.0	-0.8	1.0	0.6	0.2	-0.5	-0.4
Total heroin consumption	1.6	1.9	3.2	1.8	-0.9	-1.1	-1.3	1.5	1.6
Bone: trabecular number	0.1	0.1	0.2	-0.4	-0.0	0.3	0.2	-0.4	-0.3
Bone: trabecular spacing	0.4	0.6	1.0	-0.3	0.9	0.8	1.0	-0.7	-0.5
Bone: trabecular thickness	0.1	0.1	0.3	-0.3	-0.4	-0.3	-0.3	-0.3	-0.5
Bone: trabecular tissue density	0.4	0.6	1.8	-0.9	0.0	-0.3	-0.2	-1.1	-1.3
Water consumed over 24 hours	0.2	0.4	0.9	0.7	-0.2	-0.5	0.6	-0.9	-0.7
Number of responses in last shaping day	3.2	4.1	6.1	2.3	-1.4	-1.7	-2.1	2.5	2.0