Snx11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr10_82246133_82249076	0.03	0.03	4.0e-03	0.03	0.02	0.02	0.02	7.7e-04	4.7e-03	1.5e-03	3.9e-03
2	Adipose	gene expression	Snx11	0.03	0.03	1.7e-03	0.02	0.01	0.01	0.02	1.5e-03	8.8e-03	4.0e-02	2.3e-03
3	Liver	isoform ratio	NM_001199169.1	0.02	0.02	5.3e-03	0.02	0.01	0.01	0.01	5.0e-03	7.1e-03	8.9e-03	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	2.0	3.4	3.7	1.9	-1.9	1.7
Area under the delay curve	0.4	0.4	0.6	-0.5	0.6	-0.8
BMI with tail	14.1	48.8	53.0	7.3	-7.3	6.4
BMI without tail	0.7	2.2	2.9	1.7	-1.7	1.0
Body weight	0.9	4.1	5.1	2.3	-2.2	1.5
Weight adjusted by age	0.7	1.0	1.2	-1.1	0.9	-1.0
Bone surface	0.6	1.1	1.2	1.1	-1.0	1.0
Bone volume	1.8	3.2	3.6	1.9	-1.8	1.7
Breakpoint value in progressive ratio session	2.5	3.0	3.7	-1.6	1.6	-1.9
Number of licking bursts	0.1	0.1	0.2	-0.2	0.4	-0.5
Context. condit. distance diff. score	0.2	0.2	0.3	0.5	-0.4	0.6
Locomotion velocity, session 1	0.2	0.3	0.4	0.5	-0.6	0.4
Locomotion distance, session 1	2.9	3.7	4.4	-1.8	1.8	-2.1
Locomotion velocity, session 2	1.2	1.4	1.8	-1.1	1.0	-1.3
Locomotion distance, session 2	3.9	5.5	7.0	-2.2	2.1	-2.6
Locomotion velocity, session 3	0.0	0.0	0.0	0.0	0.0	-0.0
Locomotion distance, session 3	3.5	3.8	4.0	-1.9	1.9	-2.0
Stereotopy head waving bouts, day 3	4.9	5.8	5.9	2.4	-2.4	2.4
Stereotopy head waving duration, day 3	4.0	4.8	4.9	2.2	-2.2	2.2
Locomotion velocity, session 7	1.6	1.8	2.3	-1.2	1.2	-1.5
Locomotion distance, session 7	5.5	6.9	8.0	-2.6	2.5	-2.8
Stereotopy head waving bouts, day 7	0.6	0.6	1.1	0.6	-0.7	1.0
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.5	-0.5	0.9
Locomotion velocity, session 8	0.0	0.0	0.0	-0.0	-0.0	-0.1
Locomotion distance, session 8	1.0	1.5	1.9	-1.1	1.1	-1.4
Degree of sensitization distance	0.0	0.0	0.1	0.0	-0.1	-0.4
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	0.2	0.1
Conditioned locomotion	1.2	1.4	1.8	1.1	-1.1	1.3
Cocaine response after cond. corrected	5.6	6.8	8.5	2.4	-2.4	2.9
Cocaine response after cond. not corrected	3.2	3.7	5.3	1.8	-1.7	2.3
Cocaine response before conditioning	2.4	2.9	3.3	-1.7	1.8	-1.6
Saline control response	0.4	0.5	0.7	-0.6	0.8	-0.7
Bone: connectivity density	0.3	0.4	0.5	0.6	-0.6	0.7
Bone: cortical apparent density	6.8	9.3	11.5	-3.4	3.3	-2.4
Bone: cortical area	0.1	0.1	0.2	0.4	-0.4	0.1
Bone: cortical porosity	0.4	0.5	0.7	0.5	-0.6	0.9
Bone: cortical porosity	0.6	0.6	0.9	0.7	-0.8	0.9
Bone: cortical thickness	0.4	0.6	0.7	-0.7	0.8	-0.9
Bone: cortical thickness	0.6	0.7	1.0	-0.9	1.0	-0.6
Bone: cortical tissue density	7.4	10.0	12.3	-3.5	3.4	-2.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.6	-0.5	0.6
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	0.4	-0.2
Condit. Reinf. inactive responses	0.4	0.5	0.7	-0.8	0.8	-0.4
Incentive salience index mean	0.3	0.3	0.4	-0.5	0.6	-0.6
Condit. Reinf. lever presses	0.7	1.0	1.1	-0.9	1.0	-1.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.2	-0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.6	0.7	-0.6	0.8
Condit. Reinf. active responses	0.0	0.1	0.1	-0.2	0.1	-0.4
Condit. Reinf. inactive responses	0.6	0.8	1.2	-0.8	0.8	-1.1
Condit. Reinf. lever presses	0.9	1.2	1.4	-1.2	1.1	-1.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	-0.5	0.4	-0.7
Conditioned reinforcement - actives	0.4	0.7	0.9	0.7	-0.9	0.9
Conditioned reinforcement - inactives	0.1	0.1	0.4	0.2	0.1	-0.6
Conditioned locomotion	3.5	4.6	5.4	1.9	-2.3	2.2
Patch foraging indifference point 0 sec	0.8	1.6	1.9	1.2	-1.2	1.4
Patch foraging indifference point AUC	0.2	0.3	0.4	-0.6	0.6	-0.3
Delay disc. indifference point, 0s delay	1.4	1.6	1.9	-1.1	1.2	-1.4
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	0.8	-0.7	0.5
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.3	0.4	-0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	-0.5	0.5	-0.4
Delay disc. indifference point, 4s delay	3.6	3.7	4.1	-1.8	2.0	-2.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	0.2	-0.2
Indifference point function ln k	0.0	0.0	0.0	-0.0	0.1	0.1
Indifference point function log k	0.0	0.0	0.0	-0.0	0.1	0.1
Patch foraging total patch changes 0 sec	0.8	1.6	1.9	1.2	-1.2	1.4
Patch foraging total patch changes 12 sec	0.2	0.3	0.8	0.0	-0.1	0.9
Patch foraging total patch changes 18 sec	1.0	1.5	2.2	1.1	-1.1	1.5
Patch foraging total patch changes 24 sec	1.2	2.1	2.6	1.3	-1.4	1.6
Patch foraging total patch changes 6 sec	0.5	0.7	1.5	0.6	-0.5	1.2
Patch foraging time to switch 0 sec	0.0	0.1	0.1	0.2	-0.3	0.3
Patch foraging water rate 0 sec	0.7	1.5	1.6	1.3	-1.3	1.1
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.2	0.4	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.2	-0.3	0.4	-0.5
Patch foraging water rate 24 sec	0.7	1.0	1.1	1.0	-1.1	1.0
Patch foraging water rate 6 sec	0.0	0.0	0.0	0.2	0.0	-0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.7	0.7	-0.7	0.8
Distance traveled before self-admin	0.0	0.1	0.1	-0.2	0.3	-0.2
Distance traveled after self-admin	0.7	0.8	1.8	0.7	-0.4	1.3
Extensor digitorum longus weight	0.0	0.1	0.3	0.4	-0.5	-0.0
Bone: elastic displacement	0.3	0.3	0.5	0.6	-0.7	0.2
Bone: elastic work	0.0	0.0	0.0	0.1	-0.1	-0.2
Bone: endosteal estimation	0.5	1.1	1.2	1.0	-1.1	1.0
Bone: endosteal perimeter	0.9	1.9	2.4	1.4	-1.5	1.1
Epididymis fat weight	0.1	0.3	0.3	0.6	-0.6	0.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.2	0.2	0.1
Delta time in open arm before/after self-admin	1.8	1.8	2.0	-1.4	1.4	-1.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.5	-0.3	0.7	-0.5
Delay discount exponential model param	0.6	0.6	0.8	0.7	-0.7	0.9
Extinction: sum of active levers before priming	0.4	0.4	0.7	-0.9	0.7	-0.4
Active lever presses in extinction session 6	0.2	0.2	0.4	0.6	-0.6	0.2
Bone: final force	0.3	0.5	0.7	0.6	-0.6	0.8
Bone: final moment	0.3	0.5	0.8	0.7	-0.6	0.9
Food consumed during 24 hour testing period	1.0	1.4	1.9	-1.4	1.3	-0.8
Glucose	1.0	1.5	1.9	1.4	-1.4	0.8
Heart weight	1.6	2.5	2.9	1.7	-1.7	1.4
Delay discount hyperbolic model param	0.5	0.6	0.8	0.7	-0.7	0.9
Intermittent access intake day 1-15 change	0.5	1.1	1.5	1.2	-1.1	0.8
Intermittent access intake escalation	0.4	0.9	1.3	1.1	-1.0	0.7
Intermittent access intake escalation 2	2.3	2.6	3.4	1.8	-1.6	1.3
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.4	-0.3	0.5	-1.2
Intermitt. access day 15 inactive lever presses	1.1	2.2	3.1	1.8	-1.5	1.1
Intermitt. access escalation Index	0.3	0.5	1.4	0.1	-0.2	1.2
Intermittent access day 1 total infusions	0.2	0.3	0.4	-0.7	0.5	-0.2
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.6	-0.5	0.6
Intermittent access total infusions	0.0	0.0	0.0	0.0	-0.0	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.4	0.2	-0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.3	-0.5	0.5
Intermittent access total locomotion	0.4	0.5	0.7	0.6	-0.8	0.7
Intermittent access standard deviation	1.8	3.8	4.9	2.2	-2.1	1.5
Left kidney weight	0.0	0.0	0.0	0.2	-0.2	-0.0
Right kidney weight	0.4	1.7	2.1	1.4	-1.4	1.0
Cocaine induced anxiety	0.1	0.2	0.3	0.4	-0.5	0.3
Post-drug Anxiety	0.0	0.0	0.1	-0.1	0.1	-0.2
Baseline Anxiety	0.6	0.7	1.0	-0.7	0.8	-1.0
Tail length	12.8	50.0	52.9	-7.3	7.2	-6.7
Length with tail	5.0	21.8	22.4	-4.7	4.7	-4.6
Length without tail	0.1	0.2	0.2	0.4	-0.4	0.4
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.2	-0.1
Lifetime Intake	0.0	0.0	0.0	0.0	-0.0	0.2
Liver weight, left	0.1	0.1	0.3	-0.1	0.2	-0.5
Liver weight, right	0.1	0.1	0.2	-0.4	0.4	-0.1
Locomotor activity	0.9	1.4	1.9	1.1	-1.0	1.4
Locomotor testing distance	1.7	3.1	4.0	1.6	-1.7	2.0
Locomotor testing rearing	0.1	0.2	0.3	0.4	-0.3	0.5
Locomotion in novel chamber	0.8	1.0	1.1	-1.1	1.0	-0.9
Locomotion in novel chamber post-restriction	0.6	1.0	1.3	1.1	-1.2	0.8
Fecal boli incidents, locomotor time 1	3.1	4.5	5.3	2.3	-2.2	1.8
Change in fecal boli incidents, locomotor task	3.3	3.2	3.7	-1.9	1.8	-1.7
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.7	-0.8	0.7	-0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.1	-0.0	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.4	-0.2	0.4
Rest time, locomotor task time 1	0.4	0.5	0.9	0.9	-0.6	0.3
Distance moved, locomotor task time 1	0.9	1.3	2.1	-1.4	1.3	-0.6
Vertical activity count, locomotor time 1	0.3	0.7	1.3	-1.1	0.8	-0.0
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.3	-1.1	1.1	-0.6
Bouts of movement, locomotor time 2	0.0	0.1	0.1	0.3	-0.2	0.3
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.3	-0.1	0.2
Rest time, locomotor task time 2	1.1	1.4	1.7	-1.0	1.2	-1.3
Distance moved, locomotor task time 2	0.1	0.2	0.4	-0.6	0.3	0.0
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.3	-0.0	0.6
Light reinforcement 1	0.1	0.3	0.4	0.5	-0.6	0.6
Light reinforcement 2	0.1	0.1	0.3	0.1	-0.1	0.5
Bone: marrow area	0.4	0.8	0.9	0.8	-1.0	0.9
Bone: maximum diameter	0.8	1.6	1.7	1.3	-1.3	1.2
Bone: maximum force	0.5	0.9	1.2	0.9	-0.8	1.1
Bone: maximum moment	0.6	1.1	1.5	0.9	-0.9	1.2
Mean time between licks in bursts	0.0	0.1	0.1	0.3	-0.3	-0.1
Mean num. licks in bursts	0.0	0.0	0.1	-0.2	0.1	-0.0
Cd content in liver	0.0	0.0	0.0	0.1	0.0	0.2
Co content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Cu content in liver	2.1	2.4	3.8	-1.7	1.9	-0.8
Fe content in liver	0.3	0.3	0.4	-0.6	0.6	-0.5
K content in liver	0.1	0.1	0.1	0.4	-0.2	0.1
Mg content in liver	2.2	2.2	2.5	-1.4	1.6	-1.5
Mn content in liver	4.1	4.6	4.8	-2.1	2.1	-2.2
Na content in liver	2.3	2.4	2.6	1.6	-1.5	1.6
Rb content in liver	0.5	0.6	0.9	-0.9	1.0	-0.3
Se content in liver	0.5	0.5	0.7	0.9	-0.7	0.6
Sr content in liver	2.0	1.7	1.8	-1.3	1.3	-1.4
Zn content in liver	0.2	0.2	0.5	0.7	-0.4	0.2
Bone: minimum diameter	0.1	0.1	0.2	0.3	-0.5	0.3
Time in familiar zone, hab. session 1	0.8	0.8	0.9	-0.8	1.0	-0.8
Time in novel zone, hab. session 1	3.7	3.7	4.0	1.9	-1.9	2.0
Total zone transitions, hab. session 1	6.7	9.4	9.4	-3.1	3.0	-3.1
Total locomotion distance, hab. session 1	3.1	4.4	4.7	-2.0	2.2	-2.1
Locomotion velocity, hab. session 1	4.0	5.7	6.4	-2.3	2.3	-2.5
Time in familiar zone, hab. session 2	0.3	0.4	0.5	0.6	-0.5	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.2	0.1	-0.5
Total zone transitions, hab. session 2	1.8	2.3	2.7	-1.6	1.6	-1.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.3	0.3	-0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.4	0.4	-0.6
Novel to familiar place preference ratio	0.7	0.7	0.7	-0.8	0.8	-0.9
Novelty place preference	0.9	0.9	0.9	-1.0	1.0	-1.0
Time in novel zone, NPP test	0.6	0.7	0.7	-0.9	0.9	-0.8
Total zone transitions, NPP test	4.2	6.1	6.5	-2.5	2.6	-2.4
Total locomotion distance, NPP test	1.3	1.7	2.0	-1.2	1.3	-1.4
Locomotion velocity, NPP test	2.0	2.7	3.2	-1.5	1.7	-1.8
Intraocular pressure	1.4	2.0	2.4	-1.6	1.6	-1.0
Delta distance traveled before/after self-admin	0.5	0.6	1.3	0.6	-0.3	1.1
Delta ambulatory time before/after self-admin	0.5	0.6	1.2	0.7	-0.5	1.1
Parametrial fat weight	0.1	0.4	1.0	0.1	-0.2	1.0
Pavlov. Cond. lever latency	1.2	1.6	1.9	1.2	-1.2	1.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	1.9	2.0	2.3	-1.4	1.5	-1.2
Pavlov. Cond. index score	0.4	0.5	0.6	-0.7	0.7	-0.7
Pavlov. Cond. latency score	0.5	0.7	0.9	-0.8	0.7	-0.9
Pavlov. Cond. lever contacts	1.9	2.2	2.4	-1.4	1.5	-1.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.0	-0.9	1.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.5	-0.7	0.7	-0.7
Pavlov. Cond. response bias	0.4	0.5	0.6	-0.8	0.8	-0.7
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	0.8	-0.6
Pavlov. Cond. magazine entry latency	0.4	0.4	0.8	-0.5	0.5	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	-0.3	0.1
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	-0.5	0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	-0.3	-0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.5	0.7	-0.7	0.6
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	0.0	-0.0	0.4
Pavlov. Cond. intertrial magazine entries	2.0	3.0	3.6	-1.7	1.7	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.5	-0.5	0.0
Pavlov. Cond. response bias	0.5	0.7	0.8	0.9	-0.8	0.8
Time in closed arm before self-admin	1.5	2.0	2.7	1.6	-1.5	1.0
Time in closed arm after self-admin	1.3	1.3	1.7	1.3	-1.0	1.1
Time in open arm before self-admin	0.4	0.4	0.8	-0.9	0.7	-0.1
Time in open arm after self-admin	3.1	3.4	4.2	-2.0	1.9	-1.5
Bone: periosteal estimation	0.5	1.2	1.3	1.1	-1.2	1.0
Bone: periosteal perimeter	0.8	1.5	1.8	1.3	-1.3	1.0
Bone: post-yield work	0.2	0.4	0.9	0.3	-0.2	1.0
Progressive ratio test 1 active lever presses	0.4	0.5	0.9	-0.9	0.7	-0.3
Progressive ratio test 1 breakpoint	0.3	0.4	0.8	-0.9	0.6	-0.3
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.4	-0.2	-0.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.2	0.3	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.3	0.3	-0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.2	-0.0	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	0.4	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.6	-0.5	-0.1
Sum of active levers in priming session hrs 5-6	3.6	3.3	3.6	-1.9	1.9	-1.6
Progressive ratio	0.4	0.6	1.6	-0.2	0.4	-1.3
Food seeking constrained by brief footshock	0.7	0.9	1.1	1.0	-1.0	0.8
Seeking ratio, punishment vs. effort	0.4	0.5	1.5	-0.1	0.0	1.2
Retroperitoneal fat weight	0.4	1.7	2.0	1.3	-1.2	1.4
Reaction time number correct	0.1	0.3	0.6	-0.2	0.3	-0.8
Reaction time mean minus median	0.3	0.8	1.4	-1.2	1.0	-0.3
Reaction time mean minus median AUC	0.4	1.1	1.9	-1.4	1.1	-0.5
Reaction time num false alarms	0.2	0.2	0.3	-0.5	0.6	-0.3
Reaction time num false alarms AUC	0.2	0.3	0.4	-0.6	0.7	-0.3
Reaction time trials correct on left	0.1	0.3	0.6	-0.2	0.3	-0.8
Reaction time trials on left	0.1	0.3	0.7	-0.3	0.3	-0.8
Reaction time mean	0.1	0.2	0.4	-0.4	0.2	0.6
Reaction time mean AUC	0.1	0.2	0.3	-0.5	0.3	0.5
Median of all reaction times	0.2	0.3	0.9	0.1	-0.2	0.9
Reaction time omissions	0.4	0.6	1.1	-1.1	0.8	-0.4
Reaction time false alarm rate	0.0	0.1	0.1	-0.2	0.2	0.3
Reaction time premature initiation rate	0.4	0.5	0.7	-0.7	0.9	-0.6
Reaction time premature initiations	0.6	1.1	1.3	-1.0	1.1	-1.1
Std. dev. reaction times	0.3	0.5	0.9	-1.0	0.7	-0.2
Reaction time trials completed	0.1	0.3	0.7	-0.3	0.3	-0.8
Reaction time trials AUC	0.1	0.3	0.6	-0.3	0.3	-0.8
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.4	0.4	0.0
Run reversals in cocaine runway, males	0.5	0.5	0.6	0.8	-0.8	0.6
Latency to leave start box in cocaine runway	3.2	3.6	4.5	2.1	-1.7	1.9
Latency to leave start box in cocaine runway, F	3.5	4.0	5.0	2.2	-1.9	1.9
Latency to leave start box in cocaine runway, M	0.9	0.8	1.3	0.9	-0.6	1.1
Std. dev. time between licks in bursts	1.2	1.6	1.8	1.3	-1.3	1.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.4	-0.4	0.2
Short access day 1 total inactive lever presses	3.4	4.5	5.9	-1.8	2.1	-2.4
Short access day 10 total inactive lever presses	0.2	0.4	1.0	1.0	-0.6	-0.1
Short access day 1 total infusions	0.1	0.1	0.1	0.3	-0.2	0.3
Short access day 10 total infusions	0.6	0.8	1.1	0.8	-1.1	0.8
Short access total infusions	0.2	0.3	0.4	0.4	-0.5	0.6
Short access day 1 locomotion	2.0	2.4	3.1	1.8	-1.7	1.1
Short access day 10 total locomotion	1.6	3.0	4.3	1.8	-2.1	1.2
Short access total locomotion	1.8	2.2	3.0	1.6	-1.7	1.0
One hour access (0.3 mA shock)	0.3	0.4	0.5	-0.7	0.7	-0.4
Compulsive drug intake	4.2	5.0	6.1	-2.3	2.5	-1.9
One hour access (shock baseline)	1.5	2.3	2.7	1.5	-1.6	1.4
Social response proportion	0.8	0.9	1.1	-0.9	0.9	-1.0
Social responses	0.0	0.0	0.1	-0.1	0.0	-0.3
Social time	0.1	0.2	0.5	0.1	-0.1	0.7
Soleus weight	1.0	3.0	3.5	1.8	-1.9	1.4
Bone: stiffness	0.1	0.1	0.3	0.1	-0.1	0.5
Tibialis anterior weight	0.3	1.1	1.3	-1.1	1.0	-1.1
Time to tail flick, vehicle, before self-admin	3.9	4.0	4.5	-2.1	1.9	-2.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.4	-0.2	0.6
Time to tail flick, test, before self-admin	0.1	0.2	0.3	0.4	-0.5	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.1	-0.2	0.4
Delta time to tail flick, vehicle, before/after SA	3.3	3.2	3.6	1.9	-1.7	1.7
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	-0.7	0.7	-0.5
Tibia length	0.3	0.7	0.8	0.7	-0.9	0.9
Ambulatory time before self-admin	0.0	0.0	0.0	-0.0	0.1	0.0
Ambulatory time after self-admin	0.8	1.0	2.1	0.8	-0.5	1.5
Bone: tissue strength	0.0	0.0	0.0	0.1	-0.2	0.2
Total heroin consumption	1.2	1.4	1.5	-1.2	1.2	-1.2
Bone: trabecular number	1.1	1.9	2.0	1.4	-1.4	1.3
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	0.2	-0.3
Bone: trabecular thickness	2.4	3.0	3.4	1.8	-1.7	1.6
Bone: trabecular tissue density	0.2	0.3	0.6	-0.3	0.3	-0.8
Water consumed over 24 hours	0.1	0.1	0.2	-0.4	0.5	-0.2
Number of responses in last shaping day	0.1	0.1	0.2	0.5	-0.4	0.2