Hub : Genes

Snx11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr10_81749679_81752622 0.02 0.02 3.7e-03 0.02 0.02 0.02 0.02 1.2e-03 4.6e-03 1.8e-03 3.9e-03
2 Eye isoform ratio XR_005489853.1 0.69 0.2 7.2e-04 0.07 0.02 0.04 0.06 3.3e-02 1.8e-01 9.0e-02 4.0e-02
3 Liver isoform ratio NM_001199169.1 0.02 0.02 5.3e-03 0.01 0.01 0.01 0.01 6.9e-03 9.8e-03 1.3e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.42.43.1-1.81.2-1.6
Area under the delay curve0.60.71.30.3-1.20.7
BMI with tail10.132.843.4-6.64.3-6.0
BMI without tail1.02.03.1-1.60.5-1.7
Body weight0.62.64.4-1.6-2.1-1.0
Weight adjusted by age0.81.01.31.1-0.81.0
Bone surface0.30.51.1-1.1-0.2-0.7
Bone volume0.91.52.8-1.70.4-1.3
Breakpoint value in progressive ratio session3.84.24.52.1-1.92.1
Number of licking bursts0.10.10.20.40.40.2
Context. condit. distance diff. score0.20.20.6-0.4-0.0-0.8
Locomotion velocity, session 10.30.30.5-0.70.5-0.5
Locomotion distance, session 12.83.64.01.7-2.02.0
Locomotion velocity, session 21.61.93.41.0-1.81.1
Locomotion distance, session 23.44.85.91.9-2.22.4
Locomotion velocity, session 30.10.10.40.0-0.60.2
Locomotion distance, session 33.23.54.01.8-2.01.8
Stereotopy head waving bouts, day 34.14.85.5-2.42.1-2.1
Stereotopy head waving duration, day 32.63.14.2-2.11.4-1.7
Locomotion velocity, session 71.61.82.01.2-1.41.4
Locomotion distance, session 74.86.16.42.5-2.42.5
Stereotopy head waving bouts, day 70.80.91.0-0.91.0-1.0
Stereotopy head waving duration, day 70.50.60.9-0.61.0-0.7
Locomotion velocity, session 80.10.10.3-0.3-0.5-0.1
Locomotion distance, session 81.01.52.31.0-1.51.1
Degree of sensitization distance0.00.00.10.0-0.30.2
Degree of sensitization stereotypy0.20.20.50.20.7-0.2
Conditioned locomotion1.01.22.2-1.10.4-1.5
Cocaine response after cond. corrected5.05.69.3-2.41.2-3.1
Cocaine response after cond. not corrected2.73.05.7-1.80.5-2.4
Cocaine response before conditioning2.02.42.91.6-1.21.7
Saline control response0.10.20.40.3-0.00.6
Bone: connectivity density0.30.40.5-0.60.7-0.7
Bone: cortical apparent density4.05.310.43.2-0.12.3
Bone: cortical area0.10.10.2-0.4-0.40.2
Bone: cortical porosity0.50.61.1-0.70.4-1.0
Bone: cortical porosity0.30.40.7-0.70.2-0.8
Bone: cortical thickness0.20.40.50.5-0.60.7
Bone: cortical thickness1.11.32.01.1-1.40.9
Bone: cortical tissue density4.25.510.93.3-0.12.4
Condit. Reinf. active minus inactive responses0.10.10.10.30.20.2
Condit. Reinf. active-inactive response ratio0.40.40.5-0.50.7-0.7
Condit. Reinf. active responses0.10.10.30.20.50.1
Condit. Reinf. inactive responses0.20.20.30.60.30.4
Incentive salience index mean0.20.20.30.60.30.5
Condit. Reinf. lever presses0.70.91.31.10.41.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.5-0.2
Condit. Reinf. active-inactive response ratio0.70.71.0-0.61.0-0.8
Condit. Reinf. active responses0.10.10.2-0.10.40.2
Condit. Reinf. inactive responses0.30.30.80.40.20.9
Condit. Reinf. lever presses0.60.81.21.1-0.41.0
Condit. Reinf. lever reinforcers received0.10.10.20.20.20.5
Conditioned reinforcement - actives1.91.92.9-1.01.7-1.4
Conditioned reinforcement - inactives0.40.40.80.20.60.9
Conditioned locomotion3.74.45.0-2.02.1-2.2
Patch foraging indifference point 0 sec0.61.01.5-1.10.5-1.2
Patch foraging indifference point AUC0.10.10.20.30.10.5
Delay disc. indifference point, 0s delay1.01.11.40.9-1.11.2
Delay disc. indifference point, 16s delay0.20.20.4-0.6-0.3-0.4
Delay disc. indifference point, 2s delay0.60.71.40.2-1.20.8
Delay disc. indifference point, 24s delay0.70.71.30.6-1.20.5
Delay disc. indifference point, 4s delay4.54.87.51.7-2.72.0
Delay disc. indifference point, 8s delay0.10.10.10.3-0.40.3
Indifference point function ln k0.10.10.20.2-0.5-0.3
Indifference point function log k0.10.10.20.2-0.5-0.3
Patch foraging total patch changes 0 sec0.61.01.5-1.10.3-1.2
Patch foraging total patch changes 12 sec0.40.50.7-0.30.8-0.8
Patch foraging total patch changes 18 sec1.51.92.2-1.41.5-1.2
Patch foraging total patch changes 24 sec1.51.82.5-1.60.9-1.5
Patch foraging total patch changes 6 sec1.01.42.3-0.91.5-1.1
Patch foraging time to switch 0 sec0.20.30.5-0.20.7-0.5
Patch foraging water rate 0 sec0.50.81.4-1.2-0.5-0.9
Patch foraging water rate 12 sec0.40.71.80.2-1.40.4
Patch foraging water rate 18 sec0.70.92.00.6-1.40.6
Patch foraging water rate 24 sec0.50.71.1-1.00.1-1.0
Patch foraging water rate 6 sec0.00.00.0-0.2-0.20.2
Seeking ratio, delayed vs. immediate footshock0.40.50.8-0.60.6-0.9
Distance traveled before self-admin0.60.61.00.6-0.71.0
Distance traveled after self-admin1.01.12.4-1.00.0-1.5
Extensor digitorum longus weight0.20.82.1-0.5-1.4-0.0
Bone: elastic displacement0.10.10.1-0.40.3-0.2
Bone: elastic work0.10.10.3-0.0-0.50.1
Bone: endosteal estimation0.40.81.1-1.0-1.0-0.7
Bone: endosteal perimeter0.40.71.7-1.3-0.3-0.7
Epididymis fat weight0.10.30.9-0.1-0.90.2
Delta time in closed arm before/after self-admin0.10.10.20.4-0.1-0.2
Delta time in open arm before/after self-admin0.30.30.40.40.60.6
Diff in mean of infusions in LGA sessions0.10.20.30.6-0.20.3
Delay discount exponential model param0.90.92.0-0.41.4-0.8
Extinction: sum of active levers before priming1.31.32.01.2-1.40.7
Active lever presses in extinction session 60.20.20.3-0.60.5-0.2
Bone: final force0.20.30.5-0.7-0.1-0.6
Bone: final moment0.20.40.6-0.8-0.2-0.7
Food consumed during 24 hour testing period1.11.42.11.4-1.01.0
Glucose0.30.40.8-0.9-0.4-0.5
Heart weight0.81.12.8-1.70.1-0.8
Delay discount hyperbolic model param1.21.32.5-0.61.6-1.0
Intermittent access intake day 1-15 change2.52.54.0-2.01.4-1.2
Intermittent access intake escalation2.62.63.7-1.91.5-1.3
Intermittent access intake escalation 21.91.83.1-1.71.2-1.0
Intermitt. access day 1 inactive lever presses0.40.40.60.30.70.8
Intermitt. access day 15 inactive lever presses2.12.35.8-0.82.4-0.6
Intermitt. access escalation Index2.01.83.6-1.10.8-1.9
Intermittent access day 1 total infusions0.30.41.11.0-0.30.2
Intermittent access day 15 total infusions0.40.40.7-0.40.9-0.6
Intermittent access terminal intake (last 3 days)0.60.71.6-0.41.2-0.6
Intermittent access total infusions0.10.10.10.10.3-0.3
Intermittent access day 1 locomotion0.20.20.50.70.20.2
Intermittent access day 15 total locomotion0.50.61.1-0.61.0-0.5
Intermittent access total locomotion0.70.81.4-0.71.2-0.8
Intermittent access standard deviation2.22.34.2-2.01.2-1.2
Left kidney weight1.13.08.40.1-2.90.7
Right kidney weight0.51.53.0-1.1-1.7-0.5
Cocaine induced anxiety0.00.00.1-0.30.1-0.1
Post-drug Anxiety0.50.51.00.70.31.0
Baseline Anxiety0.30.30.90.10.90.3
Tail length12.036.548.35.9-6.95.2
Length with tail9.735.755.65.0-7.55.1
Length without tail1.02.25.00.5-2.21.2
Times rat made contact with spout0.10.10.10.40.40.1
Lifetime Intake0.10.10.20.30.4-0.2
Liver weight, left0.91.52.70.9-1.01.6
Liver weight, right1.72.95.10.9-2.31.6
Locomotor activity1.11.72.1-1.01.4-1.5
Locomotor testing distance2.23.75.8-1.32.4-1.9
Locomotor testing rearing0.50.81.8-0.41.4-0.5
Locomotion in novel chamber0.50.71.01.0-0.60.8
Locomotion in novel chamber post-restriction2.02.54.4-1.32.1-1.2
Fecal boli incidents, locomotor time 12.42.63.8-2.01.4-1.4
Change in fecal boli incidents, locomotor task2.42.33.21.8-1.41.3
Time >=10cm from walls, locomotor time 10.30.30.60.60.80.0
Bouts of movement, locomotor time 10.10.10.2-0.2-0.4-0.0
Total resting periods, locomotor time 10.10.10.2-0.4-0.5-0.2
Rest time, locomotor task time 10.10.20.4-0.60.2-0.2
Distance moved, locomotor task time 10.91.01.61.3-1.00.7
Vertical activity count, locomotor time 10.30.30.80.9-0.50.0
Time >=10cm from walls, locomotor time 20.40.50.90.9-0.40.6
Bouts of movement, locomotor time 20.10.10.1-0.40.1-0.3
Total resting periods, locomotor time 20.10.10.1-0.40.4-0.2
Rest time, locomotor task time 20.80.91.31.10.21.2
Distance moved, locomotor task time 20.80.92.50.5-1.60.2
Vertical activity count, locomotor time 20.60.71.70.1-1.3-0.6
Light reinforcement 10.71.43.1-0.61.8-0.7
Light reinforcement 20.20.20.4-0.20.5-0.6
Bone: marrow area0.30.70.9-0.9-1.0-0.6
Bone: maximum diameter0.40.71.5-1.20.1-0.7
Bone: maximum force0.50.81.3-1.1-0.4-0.9
Bone: maximum moment0.50.91.3-1.1-0.6-1.0
Mean time between licks in bursts0.00.00.1-0.20.1-0.1
Mean num. licks in bursts0.10.10.10.2-0.40.2
Cd content in liver0.50.50.90.8-0.11.0
Co content in liver0.10.10.2-0.1-0.4-0.2
Cu content in liver1.01.22.21.5-0.80.9
Fe content in liver1.51.83.01.1-1.71.1
K content in liver0.20.20.4-0.5-0.2-0.6
Mg content in liver0.30.30.50.7-0.30.7
Mn content in liver1.41.62.61.6-0.11.5
Na content in liver1.31.41.7-1.01.3-1.2
Rb content in liver0.40.51.40.01.20.4
Se content in liver0.20.20.5-0.70.4-0.1
Sr content in liver2.62.42.91.6-1.71.4
Zn content in liver0.10.10.3-0.20.6-0.3
Bone: minimum diameter0.30.51.3-0.4-1.20.1
Time in familiar zone, hab. session 10.60.50.70.80.80.5
Time in novel zone, hab. session 12.32.33.2-1.80.9-1.7
Total zone transitions, hab. session 15.57.79.43.0-2.23.1
Total locomotion distance, hab. session 12.23.25.01.9-1.02.2
Locomotion velocity, hab. session 13.44.86.82.2-1.72.6
Time in familiar zone, hab. session 20.80.81.8-0.61.3-0.6
Time in novel zone, hab. session 20.20.20.50.2-0.70.3
Total zone transitions, hab. session 21.31.72.31.5-0.81.5
Total locomotion distance, hab. session 20.10.10.40.00.00.6
Locomotion velocity, hab. session 20.20.20.50.1-0.30.7
Novel to familiar place preference ratio1.61.73.51.0-1.90.7
Novelty place preference1.81.83.61.1-1.90.8
Time in novel zone, NPP test1.31.32.51.0-1.60.6
Total zone transitions, NPP test3.04.25.92.2-1.42.4
Total locomotion distance, NPP test0.91.22.50.9-0.41.6
Locomotion velocity, NPP test1.52.13.81.2-1.02.0
Intraocular pressure1.42.03.21.4-1.80.9
Delta distance traveled before/after self-admin2.22.44.8-1.30.7-2.2
Delta ambulatory time before/after self-admin2.32.54.6-1.50.7-2.1
Parametrial fat weight0.20.30.9-0.10.1-1.0
Pavlov. Cond. lever latency0.91.11.7-1.3-0.1-1.3
Pavlov. Cond. magazine entry latency0.20.30.80.10.9-0.2
Pavlov. Cond. change in total contacts1.21.32.41.60.21.1
Pavlov. Cond. index score0.40.50.70.80.80.6
Pavlov. Cond. latency score0.40.60.80.90.50.8
Pavlov. Cond. lever contacts1.21.42.31.50.11.3
Pavlov. Cond. magazine entry number0.40.61.4-0.5-1.2-0.2
Pavlov. Cond. intertrial magazine entries0.50.50.70.7-0.80.7
Pavlov. Cond. lever-magazine prob. diff.0.40.50.60.80.80.4
Pavlov. Cond. response bias0.40.50.80.80.90.5
Pavlov. Cond. lever latency0.50.60.80.9-0.80.7
Pavlov. Cond. magazine entry latency0.91.11.50.9-1.21.0
Pavlov. Cond. change in total contacts0.10.20.3-0.40.6-0.1
Pavlov. Cond. index score0.10.10.2-0.40.1-0.1
Pavlov. Cond. latency score0.00.00.1-0.2-0.2-0.0
Pavlov. Cond. lever contacts0.40.60.8-0.80.9-0.6
Pavlov. Cond. magazine entry number0.10.10.3-0.20.6-0.3
Pavlov. Cond. intertrial magazine entries1.72.24.31.3-0.72.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.50.0-0.1
Pavlov. Cond. response bias0.30.40.5-0.70.6-0.6
Time in closed arm before self-admin0.80.91.9-1.40.8-0.3
Time in closed arm after self-admin0.40.40.7-0.90.2-0.7
Time in open arm before self-admin0.30.30.80.9-0.3-0.2
Time in open arm after self-admin0.50.61.01.00.60.6
Bone: periosteal estimation0.30.71.4-1.2-0.5-0.6
Bone: periosteal perimeter0.30.51.1-1.1-0.5-0.4
Bone: post-yield work0.30.40.4-0.5-0.6-0.7
Progressive ratio test 1 active lever presses0.20.30.70.8-0.20.0
Progressive ratio test 1 breakpoint0.40.51.11.0-0.40.3
Progressive ratio test 1 inactive lever presses0.20.30.7-0.00.9-0.2
Progressive ratio test 2 active lever presses0.20.20.30.40.60.1
Progressive ratio test 2 breakpoint0.10.10.20.20.50.0
Progressive ratio test 2 inactive lever presses0.20.30.70.10.80.3
Incentive Sensitization - Responses0.20.20.4-0.50.60.0
Incentive Sensitization - Breakpoint0.30.30.5-0.70.7-0.2
Sum of active levers in priming session hrs 5-62.32.33.31.8-1.31.3
Progressive ratio0.40.51.4-0.1-0.11.2
Food seeking constrained by brief footshock0.60.81.2-1.10.7-0.8
Seeking ratio, punishment vs. effort0.50.71.90.10.2-1.4
Retroperitoneal fat weight0.31.11.9-1.4-1.1-0.6
Reaction time number correct0.20.30.50.1-0.60.7
Reaction time mean minus median0.50.71.51.20.60.3
Reaction time mean minus median AUC0.81.01.91.41.00.5
Reaction time num false alarms0.20.20.40.6-0.40.3
Reaction time num false alarms AUC0.20.30.50.7-0.60.4
Reaction time trials correct on left0.20.30.50.1-0.60.7
Reaction time trials on left0.20.30.50.2-0.50.7
Reaction time mean0.60.82.00.51.4-0.5
Reaction time mean AUC0.60.81.80.61.3-0.4
Median of all reaction times0.91.22.9-0.11.7-0.8
Reaction time omissions0.10.10.40.60.1-0.1
Reaction time false alarm rate0.10.10.20.4-0.2-0.2
Reaction time premature initiation rate0.40.51.11.0-0.30.6
Reaction time premature initiations0.71.01.41.2-0.71.0
Std. dev. reaction times0.30.51.11.00.60.2
Reaction time trials completed0.20.30.50.2-0.50.7
Reaction time trials AUC0.20.30.50.2-0.50.7
Run reversals in cocaine runway, females0.90.82.20.5-1.50.1
Run reversals in cocaine runway, males1.71.63.9-0.82.0-0.6
Latency to leave start box in cocaine runway2.42.64.0-2.01.0-1.7
Latency to leave start box in cocaine runway, F3.33.65.5-2.41.3-1.9
Latency to leave start box in cocaine runway, M0.80.81.2-1.00.4-1.1
Std. dev. time between licks in bursts1.01.21.5-1.21.0-1.0
Total sessions with >9 infusions0.50.60.8-0.40.9-0.9
Short access day 1 total inactive lever presses2.02.34.11.70.02.0
Short access day 10 total inactive lever presses0.70.71.90.50.21.4
Short access day 1 total infusions0.20.20.60.20.8-0.1
Short access day 10 total infusions0.40.40.8-0.40.5-0.9
Short access total infusions0.10.10.10.00.3-0.4
Short access day 1 locomotion1.01.11.4-1.11.2-0.9
Short access day 10 total locomotion0.40.40.8-0.90.6-0.2
Short access total locomotion0.80.81.4-1.20.8-0.7
One hour access (0.3 mA shock)0.30.40.80.9-0.10.6
Compulsive drug intake6.06.19.03.0-2.02.3
One hour access (shock baseline)2.42.83.4-1.91.5-1.6
Social response proportion1.31.42.70.9-1.70.8
Social responses0.10.20.40.3-0.60.2
Social time0.20.20.40.30.6-0.5
Soleus weight0.61.73.2-1.80.6-1.2
Bone: stiffness0.20.30.6-0.4-0.8-0.4
Tibialis anterior weight0.51.62.11.1-1.31.4
Time to tail flick, vehicle, before self-admin1.01.02.21.5-0.50.8
Time to tail flick, vehicle, after self-admin0.30.30.6-0.40.8-0.4
Time to tail flick, test, before self-admin0.00.00.1-0.20.1-0.0
Time to tail flick, test, after self-admin0.10.10.40.0-0.2-0.6
Delta time to tail flick, vehicle, before/after SA1.21.21.7-1.31.0-0.8
Delta time to tail flick, test, before/after SA0.30.20.40.5-0.70.1
Tibia length0.30.90.9-0.9-0.9-1.0
Ambulatory time before self-admin0.50.50.70.5-0.70.9
Ambulatory time after self-admin1.31.52.9-1.1-0.5-1.7
Bone: tissue strength0.10.10.1-0.20.2-0.3
Total heroin consumption1.11.32.21.5-0.41.2
Bone: trabecular number1.01.62.3-1.21.5-1.0
Bone: trabecular spacing0.10.10.20.20.30.5
Bone: trabecular thickness1.11.42.1-1.4-0.1-1.4
Bone: trabecular tissue density0.20.30.70.4-0.20.8
Water consumed over 24 hours0.10.20.40.70.10.3
Number of responses in last shaping day0.40.41.2-0.01.1-0.1