Smtnl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	Smtnl2	0.29	0.19	5.8e-03	0.04	0.15	0.17	0.1	7.2e-02	2.6e-03	1.3e-03	1.3e-02
2	NAcc	gene expression	Smtnl2	0.11	0.1	1.6e-07	0.04	0.04	0.04	0.04	5.1e-07	4.0e-07	1.7e-06	1.3e-06
3	pVTA	gene expression	Smtnl2	0.29	0.12	0.0e+00	0.28	0.24	0.28	0.29	9.0e-23	1.6e-19	2.6e-22	1.9e-23
4	Brain	gene expression	Smtnl2	0.17	0.1	1.6e-13	0.15	0.14	0.13	0.14	1.3e-13	4.5e-13	7.1e-12	1.3e-12
5	Adipose	gene expression	Smtnl2	0.03	0.02	6.3e-03	0.02	0.02	0.02	0.02	3.2e-03	4.7e-03	6.5e-03	4.3e-03
6	RMTg	gene expression	Smtnl2	0.23	0.13	1.3e-04	0.2	0.2	0.22	0.22	5.3e-06	4.7e-06	2.2e-06	2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.0	3.4	4.2	1.4	2.1	1.9	2.1	-1.5	2.0
Area under the delay curve	0.3	0.3	0.5	-0.6	-0.7	-0.6	-0.6	0.2	-0.6
BMI with tail	0.3	1.0	1.7	1.3	0.7	1.0	0.9	-0.9	1.1
BMI without tail	2.1	6.5	7.5	2.2	2.6	2.7	2.6	-2.4	2.7
Body weight	3.2	14.1	16.5	3.1	3.5	3.9	3.8	-4.1	4.0
Weight adjusted by age	0.2	0.4	1.1	1.0	-0.4	0.1	-0.1	1.0	0.1
Bone surface	0.9	1.7	2.3	1.5	1.1	1.2	1.4	-1.2	1.4
Bone volume	1.1	2.0	3.0	1.7	1.1	1.3	1.5	-1.1	1.5
Breakpoint value in progressive ratio session	1.6	1.9	2.5	1.6	1.3	1.5	1.6	-0.8	1.4
Number of licking bursts	0.1	0.2	0.5	-0.5	-0.2	-0.5	-0.4	0.7	-0.4
Context. condit. distance diff. score	1.1	1.3	2.4	1.6	0.8	1.2	1.1	-0.9	1.1
Locomotion velocity, session 1	3.7	4.0	4.7	2.0	1.6	2.1	2.0	-2.2	2.0
Locomotion distance, session 1	0.2	0.3	0.8	0.9	0.1	0.4	0.4	-0.5	0.4
Locomotion velocity, session 2	0.7	0.8	1.2	0.3	1.0	0.9	0.8	-1.1	0.9
Locomotion distance, session 2	0.6	0.8	0.9	0.8	0.9	1.0	0.9	-0.9	0.9
Locomotion velocity, session 3	1.1	1.3	4.1	-2.0	-0.7	-1.1	-1.0	0.1	-1.0
Locomotion distance, session 3	0.0	0.0	0.1	-0.4	-0.0	-0.2	-0.1	0.0	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.5	-0.1	0.2	0.2	0.2	-0.7	0.3
Stereotopy head waving duration, day 3	1.0	1.2	2.0	-0.9	-1.4	-1.2	-1.3	0.6	-1.1
Locomotion velocity, session 7	0.0	0.0	0.2	0.3	-0.1	-0.0	-0.1	0.4	-0.1
Locomotion distance, session 7	0.1	0.1	0.4	0.3	0.2	0.1	0.0	0.7	0.0
Stereotopy head waving bouts, day 7	1.0	1.1	2.2	1.5	0.6	1.0	1.0	-0.9	1.0
Stereotopy head waving duration, day 7	0.8	0.9	1.5	1.2	0.5	0.9	0.9	-1.1	0.9
Locomotion velocity, session 8	0.4	0.5	1.4	0.8	0.1	0.5	0.5	-1.2	0.6
Locomotion distance, session 8	2.4	3.5	4.5	2.1	1.5	1.9	1.8	-1.9	1.9
Degree of sensitization distance	0.3	0.3	1.2	1.1	0.3	0.5	0.4	0.4	0.4
Degree of sensitization stereotypy	1.6	1.8	2.4	1.6	1.1	1.4	1.4	-1.2	1.3
Conditioned locomotion	0.7	0.9	1.2	-1.1	-0.7	-1.0	-0.9	0.9	-1.0
Cocaine response after cond. corrected	0.4	0.5	1.1	0.1	1.0	0.9	0.7	-0.5	0.7
Cocaine response after cond. not corrected	0.5	0.6	1.0	0.4	1.0	0.9	0.8	-0.5	0.8
Cocaine response before conditioning	0.2	0.2	0.8	0.9	0.1	0.4	0.4	-0.1	0.4
Saline control response	0.2	0.2	1.0	1.0	-0.0	0.3	0.3	0.3	0.2
Bone: connectivity density	2.3	3.5	4.0	1.8	1.9	2.0	1.9	-1.6	2.0
Bone: cortical apparent density	0.9	1.2	2.0	-1.4	-0.6	-1.0	-1.1	1.2	-1.1
Bone: cortical area	0.5	0.7	0.9	-0.7	-0.9	-1.0	-0.7	0.8	-0.9
Bone: cortical porosity	1.1	1.2	2.1	0.1	1.4	1.1	1.1	-1.2	1.1
Bone: cortical porosity	0.5	0.5	1.1	-0.2	1.0	0.7	0.7	-0.8	0.7
Bone: cortical thickness	0.7	1.2	2.9	-1.7	-0.4	-1.0	-1.0	0.9	-1.0
Bone: cortical thickness	0.3	0.3	0.9	-1.0	0.9	0.3	0.3	-0.2	0.2
Bone: cortical tissue density	0.6	0.8	1.6	-1.3	-0.4	-0.8	-0.9	1.0	-0.9
Condit. Reinf. active minus inactive responses	0.3	0.3	1.1	-0.0	1.0	0.6	0.5	0.2	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.1	0.8	0.5	0.4	0.3	0.4
Condit. Reinf. active responses	0.3	0.4	1.1	0.2	1.1	0.7	0.6	0.2	0.6
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.1	0.3	-0.2
Incentive salience index mean	0.7	0.9	2.3	0.2	1.5	1.1	0.9	-0.2	0.9
Condit. Reinf. lever presses	1.9	2.7	5.1	0.7	2.3	1.9	1.7	-1.1	1.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	0.1	1.0	0.7	0.7	-0.2	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	-0.2	0.8	0.5	0.4	0.2	0.4
Condit. Reinf. active responses	0.1	0.2	0.4	-0.0	0.6	0.4	0.5	-0.3	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	-0.6	-0.5	-0.4	0.3	-0.4
Condit. Reinf. lever presses	0.9	1.2	2.0	-1.1	-0.8	-1.1	-1.0	1.4	-1.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	-0.2	0.4	0.2	0.2	0.1	0.2
Conditioned reinforcement - actives	0.2	0.3	0.4	0.6	0.3	0.5	0.6	-0.6	0.4
Conditioned reinforcement - inactives	0.4	0.7	3.4	1.9	-0.4	0.1	0.2	0.5	0.1
Conditioned locomotion	1.4	1.8	3.9	-0.4	-2.0	-1.4	-1.4	0.8	-1.5
Patch foraging indifference point 0 sec	0.2	0.4	1.1	-0.5	1.0	0.5	0.5	0.4	0.4
Patch foraging indifference point AUC	0.7	1.0	1.9	-0.2	-1.4	-1.0	-1.0	1.1	-1.0
Delay disc. indifference point, 0s delay	0.3	0.3	1.3	1.1	-0.1	0.5	0.4	-0.4	0.4
Delay disc. indifference point, 16s delay	0.7	0.7	1.4	-0.8	-1.2	-0.9	-0.9	-0.2	-0.9
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.5	-0.2	-0.3	-0.4	0.4	-0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.8	-0.9	-0.1	-0.4	-0.4	0.1	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.6	-0.1	-0.0	0.0	0.6	-0.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.2	-0.0	-0.2
Indifference point function ln k	0.8	1.5	3.4	-0.8	1.8	0.9	1.0	-1.4	1.0
Indifference point function log k	0.8	1.5	3.4	-0.8	1.8	0.9	1.0	-1.4	1.0
Patch foraging total patch changes 0 sec	0.2	0.3	0.9	-0.4	1.0	0.5	0.5	0.5	0.4
Patch foraging total patch changes 12 sec	0.2	0.3	1.2	0.6	-0.3	-0.1	-0.0	1.1	-0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.4	-0.1	0.1	0.1	0.6	0.1
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	-0.3	-0.8	-0.5	-0.5	0.7	-0.5
Patch foraging total patch changes 6 sec	0.7	1.1	3.1	0.1	-1.1	-0.8	-0.9	1.8	-0.8
Patch foraging time to switch 0 sec	0.2	0.5	2.3	1.5	-0.1	0.5	0.5	-0.1	0.4
Patch foraging water rate 0 sec	0.3	0.6	1.6	-1.3	-0.4	-0.7	-0.9	0.4	-0.6
Patch foraging water rate 12 sec	0.4	0.8	1.4	1.2	0.7	0.9	0.7	-0.6	1.0
Patch foraging water rate 18 sec	1.0	1.5	2.0	0.7	1.4	1.3	1.2	-1.4	1.4
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.2	-0.3	-0.3	-0.3	0.1	-0.1
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.6	-0.3	-0.4	-0.6	-0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.3	-1.2	-0.5	-0.7	-0.9	0.5	-0.6
Distance traveled before self-admin	1.3	1.7	2.9	-1.0	-1.7	-1.3	-1.4	0.8	-1.4
Distance traveled after self-admin	0.7	0.9	2.5	1.2	-1.6	-0.6	-0.6	0.4	-0.6
Extensor digitorum longus weight	0.7	2.9	10.3	3.2	0.0	1.4	1.3	-1.3	1.4
Bone: elastic displacement	0.8	0.9	1.4	-0.8	-0.8	-0.9	-1.1	1.2	-1.0
Bone: elastic work	1.2	1.5	2.7	-1.6	-0.9	-1.3	-1.2	1.1	-1.2
Bone: endosteal estimation	0.3	0.7	1.9	1.0	-1.4	-0.7	-0.3	0.5	-0.4
Bone: endosteal perimeter	0.2	0.5	1.5	1.1	-1.2	-0.5	-0.1	0.4	-0.2
Epididymis fat weight	5.2	17.8	31.5	5.6	3.2	4.4	4.3	-3.1	4.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.3	-0.5	-0.3
Delta time in open arm before/after self-admin	0.4	0.4	1.0	1.0	0.3	0.5	0.4	0.7	0.5
Diff in mean of infusions in LGA sessions	1.7	2.0	2.7	1.3	1.4	1.5	1.6	-1.2	1.5
Delay discount exponential model param	0.2	0.2	0.3	0.5	0.5	0.5	0.5	-0.1	0.5
Extinction: sum of active levers before priming	1.4	1.5	3.6	1.9	0.8	1.3	1.1	-0.8	1.2
Active lever presses in extinction session 6	2.3	2.3	3.2	1.5	1.1	1.5	1.6	-1.8	1.5
Bone: final force	0.0	0.1	0.3	0.5	-0.2	-0.1	0.2	0.3	0.0
Bone: final moment	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.0	0.5	-0.1
Food consumed during 24 hour testing period	0.3	0.4	1.2	-0.4	0.6	0.5	0.6	-1.1	0.6
Glucose	3.8	6.0	9.7	-2.0	-2.1	-2.5	-2.4	3.1	-2.5
Heart weight	1.3	2.1	3.0	1.7	1.2	1.5	1.4	-1.2	1.4
Delay discount hyperbolic model param	0.1	0.2	0.2	0.5	0.4	0.4	0.4	-0.2	0.4
Intermittent access intake day 1-15 change	1.2	2.4	3.9	-0.7	-2.0	-1.5	-1.7	1.5	-1.6
Intermittent access intake escalation	1.4	2.9	4.5	-0.6	-2.1	-1.7	-1.8	1.8	-1.8
Intermittent access intake escalation 2	2.9	3.3	4.3	-1.3	-2.1	-1.8	-1.9	1.7	-1.9
Intermitt. access day 1 inactive lever presses	1.4	5.4	11.3	-1.0	-2.1	-2.4	-2.2	3.4	-2.3
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.9	-0.3	-0.7	-0.9	-0.8	1.4	-0.8
Intermitt. access escalation Index	1.0	1.4	1.8	0.8	1.2	1.3	1.3	-0.9	1.3
Intermittent access day 1 total infusions	0.2	0.3	1.6	1.3	-0.4	0.1	0.4	0.1	0.1
Intermittent access day 15 total infusions	1.0	1.6	3.6	1.0	-1.9	-1.0	-0.8	1.4	-1.1
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.4	1.2	-1.2	-0.4	0.0	0.7	-0.4
Intermittent access total infusions	0.4	0.5	1.4	1.0	-1.2	-0.4	-0.2	0.5	-0.5
Intermittent access day 1 locomotion	0.3	0.3	1.6	1.3	-0.4	0.1	0.3	0.0	0.2
Intermittent access day 15 total locomotion	0.5	0.9	2.3	0.7	-1.5	-0.9	-0.8	0.5	-0.9
Intermittent access total locomotion	0.4	0.5	1.1	0.9	-1.1	-0.6	-0.2	0.5	-0.5
Intermittent access standard deviation	1.1	2.2	5.6	0.4	-2.4	-1.5	-1.3	1.3	-1.5
Left kidney weight	0.0	0.1	0.3	-0.1	-0.6	-0.4	-0.4	-0.2	-0.3
Right kidney weight	0.1	0.3	0.7	0.6	0.3	0.5	0.3	-0.8	0.4
Cocaine induced anxiety	0.1	0.1	0.3	-0.6	-0.1	-0.4	-0.4	0.3	-0.4
Post-drug Anxiety	1.0	1.0	1.8	0.7	1.3	1.2	1.0	-0.5	1.1
Baseline Anxiety	1.7	2.0	2.6	1.3	1.5	1.6	1.6	-0.6	1.6
Tail length	3.3	12.9	14.6	2.8	3.6	3.8	3.8	-3.8	3.7
Length with tail	3.0	13.2	17.5	2.6	3.5	3.8	3.8	-4.2	3.7
Length without tail	1.6	5.3	8.0	1.7	1.9	2.3	2.4	-2.8	2.4
Times rat made contact with spout	0.1	0.1	0.3	-0.5	0.6	0.2	0.2	0.1	0.2
Lifetime Intake	0.5	0.7	2.3	1.5	-1.0	-0.2	-0.0	0.6	-0.3
Liver weight, left	6.6	10.9	13.1	2.3	3.4	3.5	3.5	-3.6	3.3
Liver weight, right	6.2	10.7	12.4	3.1	3.0	3.4	3.5	-3.3	3.4
Locomotor activity	0.1	0.2	1.0	1.0	-0.0	0.2	0.3	0.1	0.3
Locomotor testing distance	0.3	0.6	3.1	1.7	-0.5	0.3	0.1	0.4	0.3
Locomotor testing rearing	0.4	0.7	1.7	1.3	-1.1	-0.3	-0.4	1.1	-0.4
Locomotion in novel chamber	3.5	4.4	5.7	-1.2	-2.4	-2.2	-2.3	2.2	-2.2
Locomotion in novel chamber post-restriction	0.2	0.3	0.6	-0.8	-0.3	-0.5	-0.3	0.7	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	-0.7	-0.1	-0.2	-0.2	-0.6	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.2	0.5	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.0	0.5	0.3	0.3	-0.3	0.3
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.2	0.7	0.6	0.5	-0.8	0.5
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.7	0.7	0.3	0.3	-0.6	0.3
Rest time, locomotor task time 1	0.5	0.7	1.5	-1.2	-0.5	-0.9	-0.8	0.5	-0.8
Distance moved, locomotor task time 1	0.2	0.2	1.0	1.0	0.1	0.4	0.3	0.2	0.4
Vertical activity count, locomotor time 1	0.2	0.5	1.6	1.2	0.3	0.6	0.6	0.0	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.5	0.3	-0.1	0.0	-0.2	-0.0
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.5	0.6	0.1	0.2	0.1	0.1
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.3	0.7	0.3	0.4	-0.3	0.3
Rest time, locomotor task time 2	0.2	0.3	1.0	-1.0	-0.1	-0.4	-0.4	-0.0	-0.4
Distance moved, locomotor task time 2	0.2	0.3	0.7	0.8	-0.7	-0.2	-0.2	0.6	-0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.8	0.9	-0.0	0.3	0.2	0.1	0.3
Light reinforcement 1	0.2	0.4	1.8	1.4	-0.6	0.0	-0.0	0.7	-0.1
Light reinforcement 2	0.1	0.2	0.3	-0.0	-0.6	-0.4	-0.4	0.5	-0.5
Bone: marrow area	0.3	0.6	1.8	1.0	-1.4	-0.7	-0.3	0.5	-0.4
Bone: maximum diameter	0.3	0.6	1.6	-0.1	-1.3	-0.9	-0.6	0.5	-0.8
Bone: maximum force	0.1	0.1	0.3	0.6	-0.4	-0.2	0.0	0.4	-0.1
Bone: maximum moment	0.1	0.2	0.5	0.5	-0.7	-0.4	-0.2	0.6	-0.3
Mean time between licks in bursts	0.8	1.9	2.7	1.6	0.8	1.4	1.3	-1.6	1.3
Mean num. licks in bursts	0.1	0.2	0.4	0.2	0.5	0.6	0.5	-0.6	0.5
Cd content in liver	0.2	0.2	1.0	1.0	-0.4	0.0	0.1	-0.1	0.1
Co content in liver	0.2	0.3	0.6	0.3	0.4	0.6	0.5	-0.8	0.5
Cu content in liver	0.3	0.4	1.4	-1.2	0.2	-0.4	-0.4	0.5	-0.4
Fe content in liver	1.1	1.3	1.8	1.3	1.0	1.2	1.1	-1.0	1.1
K content in liver	1.2	1.2	2.3	0.5	1.0	1.0	1.1	-1.5	1.0
Mg content in liver	0.1	0.1	0.1	-0.3	0.4	0.2	0.3	-0.4	0.2
Mn content in liver	0.2	0.2	1.0	-1.0	0.5	0.1	0.1	-0.4	0.1
Na content in liver	0.2	0.2	0.3	-0.2	-0.6	-0.4	-0.5	0.2	-0.5
Rb content in liver	0.2	0.2	0.9	0.9	0.0	0.3	0.5	-0.1	0.4
Se content in liver	0.3	0.4	0.6	-0.8	-0.4	-0.7	-0.6	0.6	-0.6
Sr content in liver	0.6	0.5	1.3	1.1	0.2	0.7	0.6	-0.6	0.6
Zn content in liver	0.7	0.7	1.1	0.5	1.1	0.9	1.0	-0.7	0.9
Bone: minimum diameter	0.1	0.2	0.7	0.8	-0.8	-0.2	0.0	-0.1	-0.1
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.0	-0.6	-0.5	-0.5	0.8	-0.5
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.1	0.6	0.5	0.5	-0.6	0.5
Total zone transitions, hab. session 1	0.5	0.7	2.9	1.7	-0.9	-0.1	-0.1	0.4	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.7	0.8	0.1	0.3	0.2	0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.5	0.7	-0.2	0.1	0.1	0.3	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.1	0.6	0.5	0.5	-0.6	0.5
Time in novel zone, hab. session 2	0.5	0.5	0.9	-0.5	-0.5	-0.7	-0.7	1.0	-0.7
Total zone transitions, hab. session 2	0.5	0.6	2.6	1.6	0.0	0.6	0.6	-0.3	0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.7	0.8	0.1	0.3	0.4	0.1	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.5	0.7	-0.0	0.2	0.3	0.0	0.2
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.1	-0.5	-0.5	-0.5	0.7	-0.5
Novelty place preference	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.1	0.4	-0.1
Time in novel zone, NPP test	0.0	0.0	0.0	0.2	0.1	0.1	0.1	0.2	0.1
Total zone transitions, NPP test	0.4	0.6	3.1	1.7	-0.4	0.3	0.3	0.2	0.2
Total locomotion distance, NPP test	0.3	0.4	0.9	0.1	-0.7	-0.6	-0.5	0.9	-0.6
Locomotion velocity, NPP test	0.8	1.1	1.8	-0.4	-1.1	-1.0	-1.0	1.3	-1.1
Intraocular pressure	1.7	2.4	5.2	-0.2	-1.7	-1.4	-1.5	2.3	-1.5
Delta distance traveled before/after self-admin	1.6	1.7	6.0	2.4	0.4	1.0	1.1	-0.6	1.1
Delta ambulatory time before/after self-admin	1.0	1.2	4.4	2.1	0.5	0.9	0.8	-0.3	1.0
Parametrial fat weight	6.8	16.0	30.7	5.5	2.8	4.2	3.9	-2.8	4.0
Pavlov. Cond. lever latency	0.3	0.3	1.2	0.3	-1.1	-0.5	-0.5	-0.2	-0.4
Pavlov. Cond. magazine entry latency	0.8	1.0	2.6	-0.6	1.6	0.9	0.9	-0.8	0.9
Pavlov. Cond. change in total contacts	0.4	0.4	1.0	-1.0	0.2	-0.4	-0.4	1.0	-0.5
Pavlov. Cond. index score	0.8	1.0	2.6	-0.1	1.6	1.0	1.0	-0.6	0.9
Pavlov. Cond. latency score	1.1	1.4	3.3	-0.0	1.8	1.2	1.2	-0.8	1.1
Pavlov. Cond. lever contacts	0.3	0.4	1.4	-0.2	1.2	0.6	0.6	0.2	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	1.0	0.6	-1.0	-0.4	-0.4	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.4	1.2	-1.0	-0.3	-0.4	0.8	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.1	-0.2	1.4	0.8	0.8	-0.4	0.8
Pavlov. Cond. response bias	0.5	0.6	1.8	-0.3	1.3	0.7	0.7	-0.1	0.7
Pavlov. Cond. lever latency	1.8	2.5	3.1	1.6	1.3	1.7	1.6	-1.8	1.6
Pavlov. Cond. magazine entry latency	0.3	0.4	1.1	-1.0	-0.2	-0.6	-0.6	0.6	-0.5
Pavlov. Cond. change in total contacts	0.5	0.8	1.6	-1.3	-0.6	-0.9	-0.8	0.8	-0.8
Pavlov. Cond. index score	2.0	2.7	3.2	-1.8	-1.4	-1.7	-1.6	1.8	-1.6
Pavlov. Cond. latency score	2.6	3.4	3.8	-1.9	-1.6	-2.0	-1.8	1.9	-1.8
Pavlov. Cond. lever contacts	0.8	1.1	1.7	-1.2	-0.7	-1.1	-1.0	1.3	-1.0
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	1.1	0.6	0.9	0.8	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.5	0.7	2.0	1.4	0.5	0.8	0.7	-0.5	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.7	3.1	-1.8	-1.4	-1.7	-1.6	1.8	-1.6
Pavlov. Cond. response bias	0.9	1.2	1.9	-1.4	-0.6	-1.1	-1.0	1.2	-1.0
Time in closed arm before self-admin	0.9	1.2	2.6	0.6	1.6	1.2	1.2	-0.3	1.1
Time in closed arm after self-admin	0.1	0.1	0.4	-0.6	0.1	-0.2	-0.0	-0.2	-0.2
Time in open arm before self-admin	1.6	1.8	2.3	-1.5	-1.2	-1.5	-1.5	0.9	-1.3
Time in open arm after self-admin	1.5	1.7	3.4	-0.4	-1.3	-1.2	-1.5	1.8	-1.1
Bone: periosteal estimation	0.2	0.5	1.6	0.5	-1.3	-0.8	-0.4	0.5	-0.6
Bone: periosteal perimeter	0.2	0.3	0.9	0.2	-1.0	-0.6	-0.3	0.4	-0.4
Bone: post-yield work	1.0	1.5	1.9	1.4	1.1	1.2	1.3	-1.0	1.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.5	-0.4	-0.0	0.1	-0.1	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.6	-0.4	0.0	0.1	-0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.7	1.1	2.5	0.7	-1.6	-1.0	-1.2	0.8	-0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.3	-0.3	-0.0	0.2	0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.1	0.2	0.4	-0.3	-0.0	0.2	0.0	-0.1
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.3	1.0	-0.9	-0.5	-0.4	1.1	-0.5
Incentive Sensitization - Responses	0.0	0.1	0.1	0.4	0.1	0.1	0.4	0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	0.4	0.1	0.1	0.4	0.0	0.1
Sum of active levers in priming session hrs 5-6	3.8	3.6	4.7	1.6	2.0	2.2	2.0	-1.6	2.0
Progressive ratio	0.6	0.9	1.9	-0.2	-1.1	-0.8	-0.8	1.4	-1.0
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.5	-0.4	-0.4	-0.3	0.1	-0.3
Seeking ratio, punishment vs. effort	0.2	0.3	1.0	-0.4	0.6	0.2	0.2	-1.0	0.5
Retroperitoneal fat weight	0.2	0.8	2.7	1.6	0.4	0.8	0.8	-0.1	0.7
Reaction time number correct	0.2	0.4	0.5	0.7	0.5	0.5	0.5	-0.6	0.6
Reaction time mean minus median	0.5	1.2	3.4	-0.9	-0.5	-0.9	-0.9	1.8	-1.1
Reaction time mean minus median AUC	0.2	0.4	1.6	-0.4	-0.2	-0.4	-0.4	1.2	-0.6
Reaction time num false alarms	0.5	0.8	1.6	-1.1	-0.2	-0.7	-0.8	1.3	-0.8
Reaction time num false alarms AUC	0.5	0.8	1.3	-1.2	-0.3	-0.7	-0.9	1.1	-0.8
Reaction time trials correct on left	0.2	0.4	0.5	0.7	0.5	0.5	0.5	-0.6	0.6
Reaction time trials on left	0.2	0.3	0.5	0.7	0.5	0.5	0.5	-0.6	0.6
Reaction time mean	0.2	0.3	0.8	-0.6	-0.2	-0.5	-0.4	0.9	-0.5
Reaction time mean AUC	0.5	0.8	1.4	-1.0	-0.5	-0.8	-0.7	1.2	-0.9
Median of all reaction times	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.2	0.5	-0.4
Reaction time omissions	0.0	0.1	0.2	0.3	0.1	0.1	0.1	0.4	0.0
Reaction time false alarm rate	0.6	0.8	1.5	-1.2	-0.4	-0.7	-0.9	1.2	-0.9
Reaction time premature initiation rate	0.4	0.5	1.1	-0.4	1.0	0.6	0.6	-0.6	0.7
Reaction time premature initiations	0.4	0.7	1.3	-0.1	1.2	0.8	0.8	-0.9	0.9
Std. dev. reaction times	0.6	1.1	2.2	-1.3	-0.4	-0.9	-0.8	1.5	-1.0
Reaction time trials completed	0.2	0.3	0.5	0.7	0.5	0.5	0.5	-0.6	0.6
Reaction time trials AUC	0.1	0.3	0.4	0.6	0.5	0.5	0.4	-0.5	0.6
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.4	-0.2
Run reversals in cocaine runway, males	1.0	1.0	1.6	0.3	-1.3	-0.9	-1.0	1.3	-0.9
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	0.1	0.0	0.1	-0.3	0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	0.2	0.8	0.7	0.8	-0.8	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.1	-0.7	-0.5	-0.6	0.2	-0.5
Std. dev. time between licks in bursts	0.3	0.4	0.7	0.9	0.3	0.7	0.5	-0.7	0.5
Total sessions with >9 infusions	0.2	0.3	0.9	1.0	-0.7	-0.2	0.1	0.5	-0.1
Short access day 1 total inactive lever presses	0.2	0.3	1.1	0.6	-0.5	-0.4	-0.3	1.0	-0.2
Short access day 10 total inactive lever presses	0.9	2.3	3.4	-0.9	-1.8	-1.7	-1.7	1.2	-1.5
Short access day 1 total infusions	1.1	1.5	2.9	0.5	-1.7	-1.1	-1.1	1.5	-1.0
Short access day 10 total infusions	0.4	0.5	0.8	0.5	-0.9	-0.6	-0.3	0.9	-0.6
Short access total infusions	0.7	0.9	1.9	0.9	-1.4	-0.8	-0.5	1.2	-0.7
Short access day 1 locomotion	1.2	1.4	2.3	-0.3	-1.5	-1.2	-1.3	1.3	-1.1
Short access day 10 total locomotion	0.9	1.6	2.8	-0.4	-1.7	-1.4	-1.2	1.2	-1.2
Short access total locomotion	1.6	1.9	3.2	-0.9	-1.8	-1.7	-1.4	1.0	-1.4
One hour access (0.3 mA shock)	0.3	0.3	1.7	1.3	-0.5	0.2	0.3	0.2	0.0
Compulsive drug intake	1.2	1.4	2.2	0.8	1.5	1.3	1.4	-0.8	1.2
One hour access (shock baseline)	0.2	0.3	1.0	0.5	-1.0	-0.4	-0.5	0.3	-0.4
Social response proportion	4.5	5.1	7.6	1.6	2.8	2.5	2.4	-1.8	2.4
Social responses	2.2	2.8	5.1	2.3	1.4	1.8	1.7	-0.7	1.7
Social time	1.9	2.6	4.4	2.1	1.5	1.7	1.6	-1.0	1.6
Soleus weight	3.9	11.5	15.3	3.3	2.7	3.5	3.4	-3.9	3.4
Bone: stiffness	1.8	2.9	4.7	2.2	1.2	1.6	1.8	-1.5	1.7
Tibialis anterior weight	2.0	6.7	14.1	3.8	1.4	2.6	2.5	-2.2	2.5
Time to tail flick, vehicle, before self-admin	2.0	2.0	3.1	1.0	1.4	1.4	1.7	-1.5	1.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	0.5	0.5	0.5	-0.1	0.5
Time to tail flick, test, before self-admin	0.8	0.8	2.3	-0.4	1.5	0.9	0.8	-0.8	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.4	0.1	-0.1	-0.4	0.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.4	2.1	-0.2	-1.4	-1.2	-1.4	1.3	-1.0
Delta time to tail flick, test, before/after SA	0.7	0.7	1.7	-0.0	-1.3	-0.9	-0.9	0.4	-0.8
Tibia length	1.0	2.9	4.2	0.5	2.0	1.7	1.7	-2.1	1.7
Ambulatory time before self-admin	0.9	1.3	2.1	-1.1	-1.4	-1.1	-1.1	0.7	-1.3
Ambulatory time after self-admin	0.3	0.3	1.5	1.2	-0.6	0.2	0.1	-0.2	0.1
Bone: tissue strength	0.6	0.6	1.2	-0.3	-0.8	-0.9	-0.7	1.1	-0.8
Total heroin consumption	5.0	5.9	7.7	2.4	2.4	2.5	2.8	-1.9	2.5
Bone: trabecular number	1.6	2.6	3.8	1.0	1.9	1.8	1.8	-1.3	1.7
Bone: trabecular spacing	0.7	0.9	1.5	-0.5	-1.2	-1.1	-1.0	0.7	-1.0
Bone: trabecular thickness	0.5	0.7	0.9	0.6	0.8	0.8	0.9	-0.8	0.9
Bone: trabecular tissue density	1.4	2.1	3.3	-1.8	-1.1	-1.6	-1.4	1.2	-1.5
Water consumed over 24 hours	0.5	0.6	1.3	-1.1	1.0	0.3	0.5	-1.0	0.5
Number of responses in last shaping day	2.1	2.3	3.9	-0.6	-1.5	-1.4	-2.0	1.8	-1.3