Hub : Genes

Smim7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Smim7 0.07 0.04 5.7e-05 0.04 0.04 0.05 0.05 2.8e-05 1.3e-05 9.2e-06 6.8e-06
2 NAcc gene expression Smim7 0.09 0.04 6.7e-16 0.1 0.1 0.09 0.1 1.1e-14 3.5e-14 2.8e-13 1.3e-14
3 pVTA gene expression Smim7 0.07 0.04 1.3e-04 0.06 0.05 0.04 0.05 1.2e-05 6.3e-05 7.5e-04 4.7e-05
4 IL gene expression Smim7 0.38 0.28 9.6e-04 0.13 0.05 0.04 0.01 5.3e-04 2.9e-02 4.7e-02 2.2e-01
5 Brain mRNA stability Smim7 0.35 0.01 5.6e-17 0.08 0.18 0.18 0.18 1.0e-07 1.3e-16 1.5e-16 2.0e-16
6 PL mRNA stability Smim7 0.09 0.04 4.1e-11 0.09 0.1 0.1 0.1 9.9e-10 1.4e-11 5.4e-11 1.5e-10
7 Liver gene expression Smim7 0.06 0.04 4.4e-05 0.02 0.03 0.04 0.03 3.4e-03 8.2e-04 4.4e-05 2.9e-04
8 BLA mRNA stability Smim7 0.15 0.08 7.8e-07 0.03 0.1 0.09 0.09 6.3e-03 6.3e-06 2.4e-05 1.2e-05
9 Brain gene expression Smim7 0.07 0.04 1.5e-08 0.08 0.04 0.1 0.07 1.3e-07 7.4e-05 1.5e-09 4.4e-07
10 NAcc mRNA stability Smim7 0.14 0.06 0.0e+00 0.09 0.17 0.16 0.16 2.2e-13 3.7e-25 1.5e-23 8.7e-24
11 Adipose gene expression Smim7 0.04 0.02 9.5e-05 0.01 0.01 0.02 0.01 2.7e-02 1.7e-02 4.6e-03 2.0e-02
12 Liver mRNA stability Smim7 0.03 0.02 2.4e-03 0 0.01 0 0 2.2e-01 1.0e-02 1.4e-01 9.0e-02
13 IC mRNA stability Smim7 0.21 0.09 6.3e-08 0.1 0.16 0.17 0.15 5.5e-05 2.9e-07 1.8e-07 6.2e-07
14 pVTA mRNA stability Smim7 0.2 0.09 1.1e-11 0.13 0.15 0.14 0.15 6.4e-11 6.2e-12 1.7e-11 4.5e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.34.07.5-2.1-1.0-0.9-0.7-2.6-2.6-0.1-2.7-1.0-2.7-0.8-2.5-2.6-2.2
Area under the delay curve0.40.40.91.00.30.50.70.70.70.50.80.90.70.40.50.60.6
BMI with tail0.31.27.1-2.70.3-0.10.3-1.3-1.31.2-1.1-0.6-1.10.4-0.7-0.9-0.6
BMI without tail0.51.65.6-2.41.21.01.4-1.2-1.11.8-0.70.5-0.91.6-0.6-0.8-0.7
Body weight1.88.027.2-5.2-0.3-0.40.2-3.7-3.72.1-3.5-1.1-3.60.5-3.0-3.1-2.7
Weight adjusted by age1.11.73.1-1.40.40.41.6-1.8-1.71.3-1.60.5-1.60.7-1.4-1.4-1.2
Bone surface1.52.84.6-1.9-1.6-1.4-1.1-1.9-1.9-0.6-2.1-1.4-2.1-1.2-1.9-1.9-1.5
Bone volume2.03.66.9-2.2-1.0-0.8-0.6-2.5-2.5-0.1-2.6-1.0-2.6-0.6-2.4-2.4-2.0
Breakpoint value in progressive ratio session1.11.33.2-0.7-1.8-1.2-1.80.50.5-1.60.1-1.70.2-1.50.50.70.9
Number of licking bursts0.10.20.60.60.30.20.40.40.5-0.00.60.80.50.70.40.50.2
Context. condit. distance diff. score0.60.71.8-0.10.1-0.10.2-1.1-1.10.7-1.00.1-1.10.2-1.2-1.2-1.3
Locomotion velocity, session 13.03.39.6-2.0-2.4-2.4-3.0-0.5-0.5-1.7-1.0-3.1-0.9-2.4-0.4-0.5-0.3
Locomotion distance, session 12.43.112.1-1.0-2.6-2.3-3.5-0.1-0.1-1.6-0.7-2.7-0.6-2.4-0.4-0.5-0.4
Locomotion velocity, session 20.91.02.8-1.7-0.4-0.4-0.8-1.2-1.20.5-1.2-1.1-1.2-0.3-1.0-1.1-1.1
Locomotion distance, session 21.62.26.8-0.8-2.2-2.0-2.60.10.2-1.9-0.4-2.4-0.2-2.10.00.30.3
Locomotion velocity, session 30.20.20.8-0.4-0.4-0.5-0.9-0.3-0.30.0-0.4-0.8-0.4-0.7-0.3-0.4-0.4
Locomotion distance, session 31.51.63.0-0.4-1.0-1.1-1.4-1.4-1.4-0.5-1.7-1.1-1.5-1.4-1.5-1.3-1.1
Stereotopy head waving bouts, day 30.20.20.7-0.7-0.7-0.8-0.60.00.2-0.40.0-0.6-0.0-0.50.10.0-0.2
Stereotopy head waving duration, day 30.10.20.6-0.8-0.5-0.5-0.70.10.2-0.20.1-0.70.0-0.30.10.0-0.2
Locomotion velocity, session 70.20.21.01.0-0.0-0.3-0.5-0.4-0.4-0.8-0.7-0.1-0.3-0.3-0.40.40.4
Locomotion distance, session 70.20.31.91.40.30.00.60.00.0-0.2-0.00.70.20.40.00.70.6
Stereotopy head waving bouts, day 71.01.13.2-1.4-1.2-1.3-1.7-0.4-0.3-0.6-0.6-1.8-0.6-1.3-0.4-0.5-0.5
Stereotopy head waving duration, day 70.50.71.8-1.4-0.7-0.8-1.1-0.6-0.60.1-0.7-1.2-0.7-0.6-0.5-0.7-0.7
Locomotion velocity, session 81.51.94.1-0.5-1.8-1.7-1.9-0.9-0.9-0.3-1.1-1.9-1.2-2.0-0.9-1.4-1.0
Locomotion distance, session 81.11.63.7-0.8-1.9-1.8-1.7-0.7-0.8-1.2-1.0-1.7-1.1-1.6-0.9-0.7-0.7
Degree of sensitization distance1.51.63.01.30.80.81.31.21.3-0.11.41.21.41.31.31.71.6
Degree of sensitization stereotypy0.91.02.2-1.4-1.0-1.1-1.3-0.7-0.7-0.2-0.9-1.5-0.9-1.1-0.7-0.8-0.7
Conditioned locomotion0.50.62.10.40.20.20.2-0.8-0.81.5-0.70.5-0.90.8-0.9-0.9-1.2
Cocaine response after cond. corrected1.31.54.91.22.02.21.60.50.31.30.71.60.71.50.50.3-0.1
Cocaine response after cond. not corrected0.60.72.40.91.21.51.2-0.1-0.31.1-0.11.2-0.00.9-0.2-0.3-0.2
Cocaine response before conditioning1.21.53.7-0.9-1.9-1.8-1.4-0.7-0.8-1.4-1.0-1.5-1.0-1.6-0.7-0.80.2
Saline control response0.60.82.2-1.3-1.5-1.3-0.80.00.0-1.4-0.0-1.4-0.1-1.10.10.30.4
Bone: connectivity density0.91.42.3-1.5-1.3-1.0-1.0-1.1-1.1-0.6-1.2-1.2-1.4-1.1-1.1-1.4-1.2
Bone: cortical apparent density0.30.40.80.00.1-0.0-0.20.80.8-0.80.8-0.50.8-0.50.90.40.5
Bone: cortical area4.36.712.5-3.00.30.40.7-3.5-3.52.0-3.30.3-3.40.9-3.3-3.3-3.1
Bone: cortical porosity0.70.72.1-1.0-1.3-1.4-1.2-0.3-0.2-0.7-0.4-1.3-0.4-1.2-0.2-0.10.1
Bone: cortical porosity0.91.02.5-1.0-1.4-1.6-1.4-0.4-0.4-0.8-0.7-1.4-0.5-1.4-0.3-0.20.0
Bone: cortical thickness5.08.415.6-3.2-0.3-0.10.4-3.9-3.91.8-3.8-0.0-3.90.6-3.8-3.8-3.6
Bone: cortical thickness5.76.813.9-1.70.10.10.7-3.6-3.61.6-3.40.8-3.50.8-3.7-3.4-3.4
Bone: cortical tissue density0.30.41.00.10.1-0.0-0.30.90.9-0.80.9-0.50.9-0.51.00.50.6
Condit. Reinf. active minus inactive responses0.50.62.0-1.4-1.0-1.1-0.7-0.5-0.5-0.4-0.6-0.9-0.7-0.7-0.6-0.6-0.5
Condit. Reinf. active-inactive response ratio0.80.81.9-0.5-0.3-0.2-0.1-1.2-1.20.6-1.20.1-1.2-0.0-1.4-1.3-1.3
Condit. Reinf. active responses0.70.82.9-1.7-1.4-1.3-1.2-0.1-0.1-0.8-0.3-1.3-0.4-1.0-0.2-0.2-0.1
Condit. Reinf. inactive responses0.40.51.0-0.6-0.8-0.4-0.80.80.8-1.00.6-0.80.6-0.50.70.80.9
Incentive salience index mean1.62.06.2-2.5-2.2-2.1-1.4-0.7-0.7-1.0-0.8-1.8-1.0-1.6-0.7-0.8-0.5
Condit. Reinf. lever presses2.73.711.1-3.3-3.1-2.9-2.1-0.6-0.5-1.5-0.8-2.8-1.0-2.3-0.5-0.8-0.3
Condit. Reinf. active minus inactive responses0.30.40.7-0.8-0.8-0.8-0.6-0.5-0.5-0.5-0.6-0.8-0.6-0.7-0.4-0.5-0.2
Condit. Reinf. active-inactive response ratio0.50.61.3-1.00.00.10.4-1.2-1.10.2-1.10.0-1.10.2-1.0-1.0-0.8
Condit. Reinf. active responses0.40.51.2-0.3-1.0-1.0-0.80.40.4-1.10.3-1.00.3-1.00.50.30.5
Condit. Reinf. inactive responses2.02.65.21.2-0.4-0.5-0.32.32.2-1.22.2-0.32.1-0.82.21.91.9
Condit. Reinf. lever presses0.00.10.3-0.30.20.20.6-0.1-0.10.10.10.4-0.00.30.1-0.10.1
Condit. Reinf. lever reinforcers received0.20.20.5-0.0-0.2-0.30.00.60.6-0.60.6-0.20.6-0.20.70.50.6
Conditioned reinforcement - actives0.71.33.70.11.81.91.4-0.9-0.91.6-0.81.0-0.71.2-0.6-0.7-0.7
Conditioned reinforcement - inactives3.65.39.7-1.22.02.11.1-3.1-3.12.5-3.00.8-2.81.7-2.6-2.3-2.4
Conditioned locomotion2.22.96.70.62.52.52.6-1.0-1.02.4-0.62.2-0.62.4-0.8-0.7-0.9
Patch foraging indifference point 0 sec0.50.92.2-1.10.2-0.00.61.21.0-1.11.50.31.20.21.30.90.9
Patch foraging indifference point AUC0.71.12.60.7-0.10.00.41.41.5-0.41.6-0.31.4-0.51.61.11.2
Delay disc. indifference point, 0s delay0.70.81.61.1-0.2-0.20.31.21.30.21.10.21.1-0.01.11.21.2
Delay disc. indifference point, 16s delay1.81.94.52.11.11.31.41.41.40.21.61.71.61.21.21.41.1
Delay disc. indifference point, 2s delay0.40.41.1-0.2-1.0-1.0-0.90.40.5-0.30.3-0.80.3-0.80.30.40.6
Delay disc. indifference point, 24s delay0.50.61.40.40.70.91.20.60.60.40.81.20.71.00.60.70.5
Delay disc. indifference point, 4s delay0.20.20.7-0.4-0.8-0.6-0.3-0.3-0.2-0.0-0.3-0.3-0.3-0.7-0.4-0.4-0.2
Delay disc. indifference point, 8s delay1.01.22.01.40.81.10.81.21.20.61.21.01.30.71.11.21.2
Indifference point function ln k1.52.65.1-0.60.90.80.6-2.2-2.21.1-2.21.1-2.01.5-2.3-1.7-1.9
Indifference point function log k1.52.65.1-0.60.90.80.6-2.2-2.21.1-2.21.1-2.01.5-2.3-1.7-1.9
Patch foraging total patch changes 0 sec0.40.81.8-1.20.60.51.01.00.8-0.71.30.51.00.61.20.80.8
Patch foraging total patch changes 12 sec0.60.82.4-0.20.30.51.01.21.2-0.11.60.41.20.11.40.60.9
Patch foraging total patch changes 18 sec2.94.49.60.9-0.5-0.40.12.93.0-1.63.1-0.52.8-0.93.02.42.6
Patch foraging total patch changes 24 sec0.81.32.3-0.4-0.9-0.7-0.41.41.4-1.21.5-1.01.3-1.21.51.01.1
Patch foraging total patch changes 6 sec1.42.15.6-0.70.20.00.82.01.9-1.12.40.02.0-0.22.21.51.5
Patch foraging time to switch 0 sec0.30.71.80.3-1.0-1.0-1.00.70.8-1.00.6-0.90.6-1.30.60.60.6
Patch foraging water rate 0 sec0.20.51.3-1.10.50.40.8-0.8-1.00.5-0.60.5-0.70.9-0.6-0.7-0.6
Patch foraging water rate 12 sec1.12.34.1-1.00.90.51.0-1.9-1.91.8-1.71.0-1.71.4-1.9-1.6-2.0
Patch foraging water rate 18 sec0.81.22.4-1.1-0.9-0.9-0.6-1.4-1.5-0.1-1.6-0.3-1.6-0.0-1.5-1.1-1.1
Patch foraging water rate 24 sec1.41.94.2-2.1-1.0-0.9-0.4-1.7-1.70.3-1.7-0.8-1.8-0.3-1.7-1.4-1.6
Patch foraging water rate 6 sec2.33.45.6-0.11.11.21.5-2.2-2.31.6-2.01.7-2.11.8-2.3-2.1-2.4
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.00.50.40.80.20.20.80.40.80.30.50.20.20.2
Distance traveled before self-admin0.20.30.7-0.9-0.1-0.10.6-0.8-0.7-0.2-0.7-0.2-0.70.1-0.6-0.5-0.4
Distance traveled after self-admin0.50.62.4-1.5-1.0-1.0-0.8-0.5-0.4-0.1-0.5-1.3-0.6-0.6-0.3-0.5-0.3
Extensor digitorum longus weight0.41.73.8-1.9-0.1-0.0-0.5-1.8-1.90.2-1.9-0.8-1.80.1-1.5-1.4-1.1
Bone: elastic displacement0.50.61.4-0.7-1.1-1.2-0.9-0.3-0.3-0.8-0.4-1.1-0.4-1.2-0.2-0.5-0.1
Bone: elastic work0.70.92.1-1.00.30.30.8-1.2-1.20.7-1.00.4-1.10.4-1.1-1.4-1.1
Bone: endosteal estimation0.40.81.31.11.01.00.80.80.90.20.91.01.00.70.91.10.9
Bone: endosteal perimeter0.20.41.30.11.00.90.90.10.11.20.31.00.31.00.10.1-0.0
Epididymis fat weight0.20.83.9-2.0-0.2-0.30.70.80.8-0.11.1-0.40.80.11.11.10.8
Delta time in closed arm before/after self-admin0.60.51.31.00.2-0.0-0.30.80.8-1.10.60.10.80.40.71.10.8
Delta time in open arm before/after self-admin0.40.41.3-0.2-0.8-0.5-1.00.30.3-0.40.2-1.10.2-1.20.30.20.4
Diff in mean of infusions in LGA sessions0.10.10.4-0.50.10.60.20.0-0.10.50.10.40.00.40.20.20.3
Delay discount exponential model param0.20.20.7-0.6-0.2-0.4-0.6-0.3-0.4-0.6-0.4-0.8-0.4-0.4-0.2-0.2-0.2
Extinction: sum of active levers before priming2.52.79.0-1.0-2.4-2.0-3.00.70.8-1.70.2-2.60.4-2.10.70.91.2
Active lever presses in extinction session 60.10.10.20.2-0.00.30.20.10.10.10.10.00.20.50.20.40.4
Bone: final force4.26.811.6-2.71.31.41.8-3.4-3.42.6-3.01.2-3.11.9-3.1-3.0-2.9
Bone: final moment3.86.29.9-2.21.61.71.9-3.1-3.12.6-2.81.5-2.82.1-2.9-2.7-2.7
Food consumed during 24 hour testing period0.60.83.3-1.1-1.8-1.6-0.7-0.2-0.1-1.2-0.3-1.1-0.3-0.6-0.20.10.5
Glucose0.10.10.9-0.90.30.3-0.0-0.1-0.10.3-0.00.20.00.40.00.20.2
Heart weight2.43.76.8-2.2-0.9-0.9-0.6-2.4-2.50.4-2.5-0.7-2.6-0.4-2.5-2.6-2.4
Delay discount hyperbolic model param0.10.10.2-0.30.1-0.1-0.3-0.1-0.2-0.5-0.2-0.5-0.2-0.1-0.0-0.1-0.1
Intermittent access intake day 1-15 change0.40.81.5-1.1-0.4-0.7-0.4-1.1-1.10.6-1.1-0.4-1.1-0.3-1.1-1.2-1.0
Intermittent access intake escalation0.40.81.5-1.0-0.4-0.7-0.4-1.0-1.00.7-1.1-0.3-1.1-0.3-1.0-1.2-1.0
Intermittent access intake escalation 20.60.71.4-0.9-0.1-0.4-0.8-1.0-1.10.4-1.2-0.4-1.0-0.3-0.9-1.0-0.8
Intermitt. access day 1 inactive lever presses0.10.30.7-0.60.30.50.1-0.8-0.80.5-0.8-0.1-0.80.3-0.6-0.5-0.5
Intermitt. access day 15 inactive lever presses0.20.52.0-0.20.60.80.4-0.8-0.81.4-0.80.2-0.70.4-0.6-0.7-0.6
Intermitt. access escalation Index0.30.41.10.7-0.2-0.0-0.51.00.9-0.51.1-0.10.9-0.20.80.50.6
Intermittent access day 1 total infusions1.82.99.11.43.03.02.3-0.1-0.12.20.32.20.42.40.20.3-0.1
Intermittent access day 15 total infusions0.91.34.00.11.71.51.2-0.9-0.92.0-0.71.2-0.71.4-0.8-0.8-0.9
Intermittent access terminal intake (last 3 days)0.81.02.60.51.61.41.1-0.8-0.81.6-0.61.1-0.51.2-0.6-0.6-0.7
Intermittent access total infusions1.82.16.50.62.52.51.9-0.6-0.62.3-0.31.6-0.21.9-0.3-0.4-0.5
Intermittent access day 1 locomotion1.21.54.80.52.12.21.9-0.1-0.11.50.21.60.21.80.20.20.0
Intermittent access day 15 total locomotion0.10.10.30.30.50.40.50.30.30.20.40.50.40.40.30.30.2
Intermittent access total locomotion1.01.22.80.11.71.61.6-0.6-0.61.6-0.41.3-0.31.5-0.4-0.4-0.5
Intermittent access standard deviation0.61.42.1-0.21.01.01.1-1.5-1.41.4-1.50.7-1.30.7-1.3-1.1-1.2
Left kidney weight0.21.16.4-2.5-1.3-1.0-0.7-0.2-0.3-1.0-0.3-1.5-0.3-1.10.2-0.00.7
Right kidney weight0.21.18.6-2.9-0.8-0.5-0.7-0.0-0.2-0.7-0.1-1.6-0.1-0.90.50.41.0
Cocaine induced anxiety0.40.61.5-0.60.30.10.80.90.9-0.21.1-0.21.00.31.20.80.9
Post-drug Anxiety0.20.30.9-0.40.40.10.90.50.50.30.60.00.60.30.70.50.6
Baseline Anxiety0.30.40.90.3-0.1-0.1-0.3-0.7-0.71.0-0.80.2-0.7-0.4-0.9-0.8-0.7
Tail length0.20.74.8-2.2-0.30.00.2-1.0-0.90.3-0.8-0.5-1.00.4-0.7-0.6-0.7
Length with tail0.83.514.2-3.8-1.2-0.9-0.8-2.2-2.20.1-2.3-1.5-2.4-0.6-1.9-1.8-1.5
Length without tail0.72.37.0-2.6-1.1-0.9-1.2-1.6-1.7-0.3-1.8-1.3-1.8-1.1-1.6-1.5-1.2
Times rat made contact with spout0.00.00.2-0.3-0.3-0.50.3-0.1-0.1-0.3-0.1-0.2-0.0-0.0-0.1-0.10.1
Lifetime Intake2.63.28.00.32.82.82.3-1.2-1.22.7-0.91.8-0.82.2-0.9-0.9-1.1
Liver weight, left1.11.74.4-1.3-1.7-1.5-2.1-1.0-1.0-0.9-1.4-1.8-1.2-1.5-1.0-0.7-0.4
Liver weight, right0.20.42.8-1.7-0.10.0-0.4-0.4-0.5-0.5-0.5-1.0-0.4-0.3-0.0-0.10.3
Locomotor activity1.21.86.2-1.9-1.9-2.5-1.70.00.1-1.8-0.2-2.0-0.1-1.50.10.10.2
Locomotor testing distance0.30.52.6-1.0-1.0-1.6-0.90.00.1-0.8-0.0-1.00.0-0.60.10.20.1
Locomotor testing rearing1.42.87.9-1.2-2.4-2.8-1.70.80.8-2.60.6-2.10.6-2.20.80.91.0
Locomotion in novel chamber0.20.21.9-1.4-0.3-0.4-0.5-0.0-0.00.1-0.0-0.6-0.1-0.60.1-0.2-0.1
Locomotion in novel chamber post-restriction2.13.49.7-1.7-2.8-2.8-3.1-0.2-0.1-2.0-0.5-2.5-0.5-2.7-0.2-0.30.0
Fecal boli incidents, locomotor time 11.62.34.91.70.70.40.51.92.0-0.31.90.92.10.71.92.21.8
Change in fecal boli incidents, locomotor task0.40.40.90.50.10.30.20.90.8-0.21.00.30.80.00.80.60.7
Time >=10cm from walls, locomotor time 11.71.83.91.30.30.20.11.91.8-0.71.80.41.90.21.82.01.7
Bouts of movement, locomotor time 10.70.71.40.3-0.5-0.5-1.00.91.0-1.00.8-0.90.9-1.20.90.81.0
Total resting periods, locomotor time 10.91.01.60.6-0.5-0.5-1.01.21.2-0.91.1-0.81.2-1.01.21.11.3
Rest time, locomotor task time 10.50.62.10.91.01.00.6-0.1-0.21.1-0.11.5-0.01.3-0.3-0.2-0.3
Distance moved, locomotor task time 10.30.40.9-0.3-0.1-0.2-0.20.80.8-0.60.7-0.60.8-0.60.90.70.8
Vertical activity count, locomotor time 10.61.43.9-1.7-0.8-0.9-1.0-0.7-0.7-2.0-0.8-2.0-0.8-1.8-0.5-0.5-0.5
Time >=10cm from walls, locomotor time 20.81.23.61.71.21.21.5-0.2-0.11.9-0.11.70.01.4-0.20.2-0.2
Bouts of movement, locomotor time 20.30.51.5-0.5-1.2-1.2-1.1-0.3-0.30.0-0.5-0.7-0.5-0.5-0.5-0.5-0.4
Total resting periods, locomotor time 20.20.41.6-0.3-1.2-1.2-1.3-0.1-0.0-0.2-0.2-0.8-0.3-0.6-0.3-0.3-0.1
Rest time, locomotor task time 20.30.41.0-0.4-0.3-0.1-0.2-0.8-0.80.2-0.80.3-0.9-0.0-1.0-0.8-0.7
Distance moved, locomotor task time 20.81.01.80.91.31.00.81.11.10.61.10.51.30.41.31.01.0
Vertical activity count, locomotor time 20.30.30.7-0.60.40.2-0.3-0.8-0.80.0-0.8-0.5-0.6-0.0-0.7-0.7-0.8
Light reinforcement 10.20.51.71.30.50.50.30.70.7-0.80.70.40.80.50.70.90.7
Light reinforcement 21.42.15.82.41.91.82.00.90.90.51.22.01.11.60.90.90.8
Bone: marrow area0.40.81.31.00.90.90.70.90.90.21.00.91.00.60.91.10.9
Bone: maximum diameter2.03.76.1-1.40.80.81.1-2.4-2.42.2-2.21.0-2.31.3-2.4-2.5-2.5
Bone: maximum force3.35.910.9-3.20.40.51.1-3.3-3.31.9-3.10.4-3.11.1-3.0-2.9-2.6
Bone: maximum moment2.84.88.8-2.50.70.81.3-3.0-3.01.9-2.70.8-2.71.3-2.8-2.6-2.4
Mean time between licks in bursts0.20.42.2-0.90.71.01.5-0.3-0.30.40.10.4-0.11.00.00.10.0
Mean num. licks in bursts0.20.40.7-0.8-0.5-0.5-0.2-0.6-0.60.0-0.7-0.8-0.6-0.8-0.6-0.7-0.3
Cd content in liver1.61.85.30.31.61.71.4-1.0-1.12.3-0.81.4-0.91.5-1.0-1.2-1.4
Co content in liver0.20.30.6-0.6-0.5-0.3-0.4-0.5-0.50.2-0.5-0.4-0.6-0.5-0.5-0.8-0.6
Cu content in liver2.02.46.5-1.4-2.5-2.6-2.3-0.1-0.1-1.2-0.3-2.1-0.6-2.5-0.4-0.9-0.6
Fe content in liver0.10.10.30.5-0.3-0.0-0.60.30.2-0.20.1-0.10.2-0.20.10.00.3
K content in liver0.40.31.41.2-0.2-0.00.20.80.8-0.20.80.60.70.10.50.50.4
Mg content in liver0.00.00.10.2-0.2-0.1-0.20.10.00.00.10.20.00.3-0.0-0.1-0.1
Mn content in liver0.20.20.4-0.5-0.5-0.4-0.5-0.2-0.1-0.3-0.2-0.5-0.3-0.6-0.3-0.6-0.5
Na content in liver1.81.93.2-0.1-1.6-1.5-1.61.31.4-1.81.1-1.51.1-1.81.31.11.4
Rb content in liver2.02.36.21.42.12.11.9-0.4-0.51.9-0.12.5-0.12.3-0.5-0.4-0.8
Se content in liver0.30.41.4-0.4-0.9-1.2-0.60.50.5-0.60.4-0.50.4-0.60.40.10.3
Sr content in liver0.30.31.00.2-0.0-0.1-0.40.50.4-1.00.3-0.70.4-0.90.60.30.5
Zn content in liver0.20.20.6-0.6-0.6-0.8-0.60.40.3-0.40.4-0.60.3-0.50.40.10.2
Bone: minimum diameter0.51.02.8-1.70.50.40.6-1.2-1.21.3-1.10.0-1.10.4-1.0-1.0-0.9
Time in familiar zone, hab. session 10.10.10.9-0.3-0.1-0.10.60.10.10.90.30.30.00.20.0-0.3-0.3
Time in novel zone, hab. session 10.20.20.60.20.10.1-0.4-0.6-0.6-0.6-0.8-0.2-0.5-0.1-0.6-0.3-0.2
Total zone transitions, hab. session 10.60.83.0-0.0-1.4-1.2-1.7-0.1-0.1-1.0-0.4-1.3-0.4-1.4-0.3-0.3-0.4
Total locomotion distance, hab. session 11.52.16.70.1-2.2-2.1-2.60.50.6-2.10.1-2.00.1-2.10.30.30.4
Locomotion velocity, hab. session 11.42.05.90.3-2.2-2.0-2.40.60.7-2.00.2-1.90.2-2.10.40.40.5
Time in familiar zone, hab. session 20.60.61.30.20.10.20.2-1.0-1.10.7-1.00.3-1.10.4-1.0-1.1-1.1
Time in novel zone, hab. session 20.50.51.10.40.60.50.40.90.9-0.30.90.41.00.20.91.01.0
Total zone transitions, hab. session 20.10.21.10.4-0.4-0.4-1.0-0.1-0.0-0.2-0.3-0.6-0.2-0.5-0.20.0-0.3
Total locomotion distance, hab. session 21.01.44.3-0.7-1.6-1.6-2.1-0.6-0.5-0.8-1.0-1.7-0.9-1.4-0.8-0.5-0.7
Locomotion velocity, hab. session 21.11.44.4-0.7-1.8-1.7-2.1-0.4-0.4-0.9-0.8-1.8-0.7-1.6-0.6-0.3-0.5
Novel to familiar place preference ratio1.01.12.41.21.21.11.40.80.70.51.01.51.01.30.80.80.9
Novelty place preference1.11.22.41.41.21.11.31.00.90.41.11.61.11.20.91.01.0
Time in novel zone, NPP test1.41.52.61.61.00.91.11.31.20.11.41.31.51.01.21.31.4
Total zone transitions, NPP test0.91.33.30.1-1.6-1.5-1.80.60.7-1.50.3-1.60.3-1.60.50.60.4
Total locomotion distance, NPP test1.62.36.1-0.5-2.4-2.3-2.5-0.5-0.4-1.5-0.9-2.2-0.9-2.1-0.7-0.4-0.5
Locomotion velocity, NPP test1.21.74.9-0.5-2.2-2.0-2.2-0.2-0.1-1.5-0.6-1.9-0.6-1.9-0.4-0.1-0.3
Intraocular pressure1.21.74.50.41.41.41.6-0.9-0.92.1-0.71.4-0.81.8-1.0-0.9-1.5
Delta distance traveled before/after self-admin0.40.41.3-1.2-0.7-0.7-0.90.40.40.00.4-1.00.2-0.70.50.00.3
Delta ambulatory time before/after self-admin0.20.30.6-0.7-0.5-0.6-0.60.50.50.00.5-0.80.4-0.50.50.20.4
Parametrial fat weight1.84.212.20.43.53.23.2-0.3-0.52.50.22.80.23.4-0.10.0-0.3
Pavlov. Cond. lever latency2.43.17.82.72.72.52.20.30.31.90.52.80.72.20.20.40.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.4-0.10.10.40.40.4-0.40.60.20.40.20.50.40.3
Pavlov. Cond. change in total contacts0.50.53.3-1.8-1.0-0.8-0.30.00.0-0.70.2-1.0-0.1-0.60.1-0.3-0.0
Pavlov. Cond. index score1.01.33.0-1.6-1.7-1.5-1.20.50.5-1.70.4-1.60.2-1.30.50.40.6
Pavlov. Cond. latency score1.51.94.7-2.0-2.2-2.0-1.50.30.3-1.90.1-2.0-0.1-1.70.30.20.4
Pavlov. Cond. lever contacts1.82.15.4-2.3-2.2-2.0-1.8-0.0-0.0-1.7-0.2-2.3-0.4-1.80.0-0.20.2
Pavlov. Cond. magazine entry number0.20.30.90.50.30.1-0.2-0.6-0.60.9-0.80.2-0.60.1-0.7-0.7-0.7
Pavlov. Cond. intertrial magazine entries1.11.42.2-1.3-1.4-1.5-1.3-1.1-1.0-0.1-1.3-1.2-1.3-1.0-1.2-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.70.92.1-1.3-1.4-1.2-0.90.40.4-1.40.4-1.30.2-1.10.50.40.6
Pavlov. Cond. response bias0.30.41.3-1.0-1.1-0.7-0.70.20.2-1.10.2-0.9-0.0-0.70.20.10.2
Pavlov. Cond. lever latency0.20.21.81.3-0.2-0.2-0.50.50.5-0.20.30.00.3-0.10.20.50.3
Pavlov. Cond. magazine entry latency0.20.22.1-1.40.50.10.50.00.10.50.2-0.20.20.30.40.00.2
Pavlov. Cond. change in total contacts0.20.32.3-1.50.30.10.90.10.00.30.30.10.20.30.4-0.20.2
Pavlov. Cond. index score0.30.42.3-1.50.60.31.0-0.3-0.30.8-0.10.4-0.10.6-0.0-0.4-0.2
Pavlov. Cond. latency score0.20.22.2-1.50.30.10.6-0.3-0.30.4-0.1-0.0-0.20.30.0-0.4-0.1
Pavlov. Cond. lever contacts0.20.22.0-1.40.10.00.5-0.4-0.4-0.0-0.3-0.1-0.30.1-0.1-0.4-0.2
Pavlov. Cond. magazine entry number0.50.63.01.7-0.9-0.5-1.10.60.6-1.20.3-0.30.4-0.80.20.60.4
Pavlov. Cond. intertrial magazine entries0.60.92.51.6-0.6-0.6-0.31.01.0-1.20.9-0.11.0-0.60.91.11.1
Pavlov. Cond. lever-magazine prob. diff.0.30.42.5-1.60.60.31.0-0.4-0.40.9-0.10.3-0.20.6-0.1-0.5-0.3
Pavlov. Cond. response bias0.20.32.4-1.60.60.20.8-0.3-0.30.4-0.10.1-0.10.40.0-0.3-0.2
Time in closed arm before self-admin2.43.16.4-2.01.21.21.6-2.1-2.12.5-1.71.0-1.81.2-1.6-2.0-1.9
Time in closed arm after self-admin2.22.46.00.02.01.82.4-1.2-1.21.8-0.82.0-0.92.2-1.0-0.9-1.2
Time in open arm before self-admin2.22.45.9-0.8-2.2-2.4-2.11.00.9-2.40.6-2.00.6-1.70.80.71.0
Time in open arm after self-admin3.43.710.1-1.8-2.7-2.7-3.2-0.5-0.6-1.8-1.0-3.2-1.0-2.7-0.6-0.8-0.4
Bone: periosteal estimation0.61.21.9-1.00.70.80.9-1.4-1.41.2-1.20.8-1.21.0-1.3-1.1-1.2
Bone: periosteal perimeter1.01.73.4-1.61.21.21.4-1.3-1.31.9-1.01.0-1.11.3-1.2-1.3-1.3
Bone: post-yield work0.00.10.20.4-0.3-0.3-0.2-0.3-0.1-0.0-0.30.1-0.2-0.2-0.30.10.1
Progressive ratio test 1 active lever presses0.40.41.4-0.61.21.10.8-0.3-0.31.2-0.10.4-0.20.8-0.1-0.3-0.3
Progressive ratio test 1 breakpoint0.40.51.3-0.61.11.10.8-0.5-0.51.1-0.30.4-0.30.9-0.2-0.4-0.4
Progressive ratio test 1 inactive lever presses0.40.61.3-0.90.30.7-0.5-1.0-1.10.6-1.1-0.7-1.00.0-0.8-0.9-0.8
Progressive ratio test 2 active lever presses1.01.23.90.71.92.01.3-0.2-0.21.80.01.40.11.40.0-0.1-0.2
Progressive ratio test 2 breakpoint1.01.13.50.71.81.91.2-0.2-0.21.70.01.30.11.40.0-0.1-0.2
Progressive ratio test 2 inactive lever presses0.81.22.6-0.11.61.61.1-1.2-1.11.6-1.00.8-0.91.2-0.8-0.8-0.9
Incentive Sensitization - Responses1.52.15.22.12.32.21.50.40.41.70.62.20.71.80.40.30.2
Incentive Sensitization - Breakpoint1.62.14.92.22.22.11.40.60.61.60.82.21.01.70.60.60.4
Sum of active levers in priming session hrs 5-60.80.73.30.5-1.4-1.1-1.80.20.3-0.6-0.2-1.10.0-1.1-0.00.20.2
Progressive ratio0.40.61.40.70.81.10.8-0.4-0.51.2-0.30.9-0.31.1-0.5-0.5-0.5
Food seeking constrained by brief footshock0.70.92.20.6-0.3-0.2-0.1-1.3-1.30.3-1.40.2-1.30.0-1.5-1.3-1.2
Seeking ratio, punishment vs. effort0.60.81.5-0.6-1.2-1.2-1.2-0.7-0.6-0.9-0.8-0.9-0.8-1.2-0.7-0.7-0.6
Retroperitoneal fat weight1.04.19.6-1.62.72.12.7-1.6-1.73.1-1.02.1-1.22.8-1.3-1.4-1.8
Reaction time number correct1.22.35.5-1.9-2.0-2.3-2.3-0.6-0.5-1.3-0.9-2.3-0.9-1.8-0.5-0.6-0.4
Reaction time mean minus median0.51.32.10.1-0.9-0.9-0.41.51.4-1.31.4-0.91.2-1.31.41.21.2
Reaction time mean minus median AUC0.40.91.50.1-0.9-0.9-1.01.11.1-1.21.0-1.00.9-1.21.00.80.7
Reaction time num false alarms0.81.12.80.1-0.4-0.4-0.71.31.3-1.71.1-0.71.2-0.81.21.41.3
Reaction time num false alarms AUC0.81.32.80.3-0.4-0.4-0.71.41.4-1.71.3-0.71.4-0.71.41.51.4
Reaction time trials correct on left1.22.35.5-1.9-2.0-2.3-2.3-0.6-0.5-1.3-0.9-2.3-0.9-1.8-0.5-0.6-0.4
Reaction time trials on left1.32.46.0-2.0-2.1-2.3-2.4-0.5-0.4-1.4-0.8-2.4-0.8-1.9-0.4-0.5-0.2
Reaction time mean2.13.46.91.41.31.41.62.42.20.12.61.02.50.82.42.11.9
Reaction time mean AUC2.94.79.71.81.01.21.32.92.8-0.63.10.83.00.42.92.72.5
Median of all reaction times3.04.37.21.92.02.12.12.32.20.62.71.72.51.52.42.21.9
Reaction time omissions1.62.46.50.1-1.0-1.0-1.41.71.6-2.61.4-1.41.5-1.21.71.91.8
Reaction time false alarm rate0.50.71.40.80.40.60.31.11.1-0.81.10.41.20.11.01.11.0
Reaction time premature initiation rate1.31.95.5-1.7-2.1-2.4-1.9-0.3-0.3-1.5-0.5-1.8-0.6-1.7-0.3-0.7-0.2
Reaction time premature initiations2.03.59.8-2.5-2.8-3.1-2.7-0.1-0.1-2.0-0.4-2.7-0.5-2.4-0.1-0.50.2
Std. dev. reaction times0.91.73.50.1-0.6-0.6-0.31.81.8-1.11.9-0.81.7-0.91.81.51.5
Reaction time trials completed1.32.46.0-2.0-2.1-2.3-2.4-0.5-0.4-1.4-0.8-2.4-0.8-1.9-0.4-0.5-0.2
Reaction time trials AUC1.02.04.8-1.9-1.8-2.0-2.2-0.5-0.5-1.2-0.8-2.2-0.8-1.7-0.4-0.5-0.3
Run reversals in cocaine runway, females2.22.24.4-1.30.40.90.7-2.1-2.10.8-2.10.6-2.10.6-2.0-1.7-1.6
Run reversals in cocaine runway, males3.53.55.7-0.1-1.6-1.8-1.52.22.2-2.41.9-1.81.9-1.92.11.92.0
Latency to leave start box in cocaine runway0.30.30.70.60.50.20.30.60.5-0.80.60.60.70.70.50.70.5
Latency to leave start box in cocaine runway, F0.10.20.9-0.20.1-0.2-0.8-0.3-0.3-0.9-0.5-0.2-0.20.1-0.3-0.0-0.1
Latency to leave start box in cocaine runway, M2.22.03.51.81.01.01.61.61.60.21.91.51.81.21.41.31.2
Std. dev. time between licks in bursts0.70.91.7-1.10.60.61.3-1.2-1.30.4-0.90.7-1.11.1-1.0-0.9-0.8
Total sessions with >9 infusions2.02.54.9-0.81.82.21.7-1.6-1.72.1-1.41.0-1.41.7-1.3-1.2-1.4
Short access day 1 total inactive lever presses3.14.07.40.12.42.71.8-2.0-2.12.5-1.81.9-1.72.2-1.9-1.7-1.9
Short access day 10 total inactive lever presses0.40.92.60.0-0.8-0.7-0.91.01.0-1.60.9-0.80.9-0.81.01.01.1
Short access day 1 total infusions4.35.79.0-1.31.92.22.0-3.0-2.92.8-2.71.3-2.71.9-2.6-2.4-2.7
Short access day 10 total infusions3.14.07.00.02.32.31.8-2.2-2.12.6-1.91.6-1.82.2-2.0-1.8-2.1
Short access total infusions2.73.57.4-0.02.52.72.2-1.7-1.72.5-1.41.6-1.32.2-1.4-1.3-1.6
Short access day 1 locomotion3.84.76.9-1.12.22.52.3-2.5-2.52.6-2.11.6-2.12.4-2.0-1.8-2.1
Short access day 10 total locomotion1.83.36.2-2.3-0.6-0.8-0.1-2.5-2.40.9-2.5-0.5-2.5-0.1-2.3-2.3-2.1
Short access total locomotion1.51.83.0-1.20.91.11.0-1.7-1.71.5-1.50.5-1.61.1-1.5-1.4-1.5
One hour access (0.3 mA shock)1.92.15.01.02.22.21.3-1.0-1.02.0-0.82.0-0.71.9-1.0-0.8-1.0
Compulsive drug intake1.11.32.61.3-0.10.00.01.61.6-0.81.60.41.50.01.41.41.3
One hour access (shock baseline)2.03.05.7-0.22.22.21.6-1.8-1.82.4-1.61.5-1.41.9-1.6-1.5-1.6
Social response proportion2.83.26.0-1.6-0.6-0.6-0.3-2.2-2.31.5-2.2-0.2-2.40.0-2.4-2.5-2.4
Social responses1.62.03.1-1.4-1.7-1.6-1.2-1.5-1.50.0-1.6-1.1-1.8-0.9-1.7-1.6-1.5
Social time0.30.30.8-0.9-0.6-0.7-0.7-0.5-0.5-0.2-0.6-0.6-0.6-0.3-0.7-0.3-0.7
Soleus weight0.41.13.70.71.51.91.60.40.20.50.61.50.51.70.40.50.4
Bone: stiffness3.25.29.4-2.70.70.61.0-3.1-3.12.3-2.90.5-2.91.4-2.8-2.7-2.6
Tibialis anterior weight0.51.75.0-2.1-1.6-1.6-1.60.20.2-1.80.0-2.20.1-1.70.40.30.7
Time to tail flick, vehicle, before self-admin1.41.43.51.41.71.71.1-0.5-0.51.8-0.31.9-0.21.9-0.5-0.2-0.5
Time to tail flick, vehicle, after self-admin0.50.61.9-0.61.21.11.0-0.6-0.71.0-0.40.7-0.31.4-0.3-0.3-0.4
Time to tail flick, test, before self-admin1.71.83.1-0.51.10.51.4-1.5-1.51.8-1.31.2-1.31.2-1.5-1.6-1.5
Time to tail flick, test, after self-admin2.12.23.61.91.51.51.81.11.01.81.51.91.31.90.90.90.7
Delta time to tail flick, vehicle, before/after SA0.30.31.2-1.1-0.5-0.4-0.5-0.3-0.4-0.9-0.4-0.9-0.4-0.6-0.2-0.3-0.2
Delta time to tail flick, test, before/after SA0.90.91.61.20.30.70.21.21.20.51.30.51.30.51.11.21.1
Tibia length1.23.46.9-2.1-0.6-0.10.1-2.6-2.51.1-2.5-0.0-2.60.2-2.5-2.3-2.0
Ambulatory time before self-admin0.30.41.4-1.2-0.00.00.5-0.9-0.9-0.2-0.8-0.2-0.80.1-0.6-0.6-0.5
Ambulatory time after self-admin0.70.94.6-2.2-0.9-1.1-0.8-0.6-0.5-0.4-0.6-1.5-0.6-0.7-0.2-0.5-0.3
Bone: tissue strength0.20.20.50.30.30.10.20.50.4-0.00.40.10.60.20.60.50.7
Total heroin consumption0.91.02.2-0.1-1.2-0.8-1.40.80.8-1.50.6-1.20.7-1.00.81.21.2
Bone: trabecular number1.22.05.1-2.2-1.1-0.9-0.9-1.5-1.5-0.6-1.6-1.6-1.7-1.1-1.3-1.6-1.3
Bone: trabecular spacing0.50.71.00.90.60.70.80.90.90.60.91.00.90.80.81.00.8
Bone: trabecular thickness3.34.18.2-1.8-0.9-0.9-0.7-2.7-2.8-0.3-2.9-0.9-2.8-0.5-2.7-2.7-2.3
Bone: trabecular tissue density0.20.30.60.0-0.6-0.6-0.20.70.7-0.80.7-0.20.7-0.60.70.40.7
Water consumed over 24 hours0.71.01.8-1.3-1.3-1.3-0.8-0.9-0.8-0.8-1.0-1.1-1.0-0.8-0.9-0.8-0.5
Number of responses in last shaping day0.60.61.1-0.50.20.40.0-1.1-1.10.9-1.00.2-1.00.3-1.0-1.0-1.0