Smim45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Smim45 0.13 0.08 5.8e-03 0.05 0.07 0.05 0.08 2.1e-02 1.0e-02 3.1e-02 6.2e-03
2 Brain mRNA stability Smim45 0.41 0.12 0.0e+00 0.39 0.38 0.38 0.38 1.8e-38 9.2e-37 2.3e-37 9.6e-38
3 IL mRNA stability Smim45 0.41 0.16 1.2e-05 0.18 0.18 0.13 0.16 3.5e-05 4.7e-05 4.4e-04 1.4e-04
4 BLA mRNA stability Smim45 0.12 0.07 4.6e-04 0.06 0.06 0.06 0.06 2.2e-04 6.8e-04 5.9e-04 5.0e-04
5 Brain gene expression Smim45 0.11 0.06 2.1e-09 0.11 0.09 0.08 0.11 1.8e-10 6.7e-09 7.5e-08 2.8e-10
6 PL mRNA stability Smim45 0.15 0.06 2.4e-15 0.13 0.13 0.13 0.15 4.4e-14 1.7e-14 2.9e-14 8.0e-16
7 LHb mRNA stability Smim45 0.31 0.14 2.4e-04 0.16 0.12 0.13 0.14 1.3e-04 9.1e-04 5.2e-04 3.6e-04
8 OFC mRNA stability Smim45 0.47 0.13 1.2e-07 0.26 0.3 0.31 0.3 7.6e-07 9.3e-08 3.7e-08 5.3e-08
9 OFC gene expression Smim45 0.26 0.13 4.3e-03 0.16 0.08 0.11 0.14 1.7e-04 5.7e-03 1.4e-03 2.9e-04
10 pVTA gene expression Smim45 0.17 0.12 3.6e-03 0.02 0.02 0.02 0.03 5.8e-02 6.3e-02 3.4e-02 1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.30.80.9-0.7-0.2-0.6-0.80.6-0.3-0.3-0.30.4
Area under the delay curve0.30.30.60.3-0.8-0.8-0.7-0.40.7-0.7-0.60.1-0.3
BMI with tail0.82.56.3-2.50.80.30.82.4-0.40.2-0.32.4-2.3
BMI without tail0.00.10.3-0.10.4-0.20.30.3-0.0-0.10.10.5-0.4
Body weight0.83.57.6-2.82.01.91.92.6-1.91.81.10.7-0.8
Weight adjusted by age1.01.22.20.11.31.01.1-0.1-1.11.01.2-1.51.4
Bone surface0.40.71.90.60.60.80.7-0.6-0.50.70.5-1.31.4
Bone volume0.10.20.60.30.40.60.5-0.3-0.30.50.4-0.60.8
Breakpoint value in progressive ratio session0.50.61.0-0.0-0.9-0.8-0.7-0.10.9-1.0-0.90.8-0.6
Number of licking bursts0.20.30.60.8-0.4-0.6-0.4-0.70.5-0.5-0.4-0.30.3
Context. condit. distance diff. score4.75.69.8-3.12.62.62.72.8-2.72.62.00.1-0.1
Locomotion velocity, session 11.31.42.10.11.21.31.3-0.3-1.31.41.2-1.41.5
Locomotion distance, session 10.91.24.02.0-0.6-0.2-0.5-2.00.2-0.20.3-1.31.2
Locomotion velocity, session 20.30.41.3-0.21.10.61.20.4-0.60.50.50.1-0.2
Locomotion distance, session 22.23.14.42.1-2.1-1.9-2.0-2.01.9-1.8-1.80.4-0.5
Locomotion velocity, session 31.11.32.0-0.31.41.21.40.1-1.31.31.4-0.91.0
Locomotion distance, session 30.60.61.51.2-0.00.1-0.0-1.2-0.10.20.8-1.21.2
Stereotopy head waving bouts, day 30.70.81.4-0.81.11.01.11.2-1.00.90.5-0.30.3
Stereotopy head waving duration, day 33.03.66.0-1.92.42.12.42.1-2.22.11.4-0.50.5
Locomotion velocity, session 70.20.20.3-0.50.60.30.60.5-0.30.20.50.1-0.2
Locomotion distance, session 70.91.11.7-0.1-1.1-1.1-1.10.11.2-1.2-1.01.2-1.3
Stereotopy head waving bouts, day 76.37.110.5-1.43.13.23.11.6-3.23.22.7-2.12.0
Stereotopy head waving duration, day 74.75.78.3-1.22.72.82.81.5-2.92.82.6-1.91.8
Locomotion velocity, session 81.31.52.8-1.71.51.21.61.3-1.51.40.50.3-0.3
Locomotion distance, session 80.71.01.7-1.11.21.01.30.6-1.31.10.9-0.10.1
Degree of sensitization distance2.02.05.3-1.9-0.3-0.6-0.31.90.4-0.6-1.22.3-2.3
Degree of sensitization stereotypy5.35.88.9-1.02.63.02.61.2-2.93.02.6-2.12.0
Conditioned locomotion1.21.32.5-0.71.21.31.20.9-1.31.41.6-0.80.8
Cocaine response after cond. corrected0.10.10.2-0.30.40.10.40.0-0.40.30.40.00.1
Cocaine response after cond. not corrected0.10.20.5-0.20.70.10.7-0.2-0.40.20.5-0.20.3
Cocaine response before conditioning0.10.10.30.50.1-0.30.1-0.50.3-0.5-0.1-0.20.1
Saline control response1.41.83.60.21.51.21.6-0.1-1.11.01.5-1.81.9
Bone: connectivity density0.10.20.40.6-0.5-0.1-0.5-0.30.4-0.2-0.3-0.40.4
Bone: cortical apparent density0.30.40.90.9-0.9-0.5-0.9-0.60.8-0.6-0.4-0.20.3
Bone: cortical area1.01.53.1-1.81.41.51.41.4-1.31.30.70.4-0.4
Bone: cortical porosity0.30.40.8-0.70.90.50.90.6-0.60.50.5-0.30.4
Bone: cortical porosity0.80.91.7-1.11.30.91.31.0-1.00.90.7-0.30.3
Bone: cortical thickness0.71.23.1-0.8-0.8-0.6-0.90.70.8-0.7-1.21.7-1.7
Bone: cortical thickness1.11.23.4-0.7-0.7-0.9-0.70.80.7-0.8-1.21.9-1.8
Bone: cortical tissue density0.30.40.90.9-0.9-0.5-0.9-0.60.8-0.6-0.4-0.20.3
Condit. Reinf. active minus inactive responses0.50.60.90.2-0.8-0.7-0.7-0.40.8-0.8-0.90.9-1.0
Condit. Reinf. active-inactive response ratio0.20.20.5-0.70.50.50.50.5-0.40.40.20.2-0.3
Condit. Reinf. active responses1.72.13.11.3-1.6-1.7-1.4-1.41.7-1.8-1.40.8-0.9
Condit. Reinf. inactive responses2.53.04.52.1-1.9-2.1-1.7-1.92.0-2.1-1.50.1-0.2
Incentive salience index mean1.21.42.00.6-1.3-1.3-1.2-0.71.4-1.3-1.31.2-1.3
Condit. Reinf. lever presses1.01.42.11.1-1.2-1.4-1.1-0.91.4-1.4-1.20.9-1.0
Condit. Reinf. active minus inactive responses0.30.41.1-0.3-0.7-0.5-0.70.30.6-0.4-1.10.8-0.8
Condit. Reinf. active-inactive response ratio0.70.72.0-0.3-0.8-0.7-0.80.40.7-0.5-1.41.0-1.0
Condit. Reinf. active responses0.30.41.0-1.00.50.60.50.9-0.50.6-0.00.4-0.4
Condit. Reinf. inactive responses0.91.11.7-1.31.31.21.31.1-1.11.11.00.1-0.1
Condit. Reinf. lever presses0.40.51.10.5-0.8-0.8-0.8-0.50.8-0.8-1.1-0.2-0.0
Condit. Reinf. lever reinforcers received0.10.20.5-0.70.10.30.10.7-0.20.3-0.30.3-0.3
Conditioned reinforcement - actives0.50.51.4-0.90.70.80.71.2-0.80.70.70.00.0
Conditioned reinforcement - inactives0.60.61.0-0.1-0.9-0.7-1.00.10.8-0.8-1.01.0-0.9
Conditioned locomotion1.11.33.8-1.80.80.50.82.0-0.70.50.11.3-1.3
Patch foraging indifference point 0 sec0.50.81.50.7-1.2-1.0-1.0-0.81.1-1.0-1.2-0.20.2
Patch foraging indifference point AUC0.00.10.20.3-0.4-0.2-0.2-0.30.2-0.1-0.3-0.00.1
Delay disc. indifference point, 0s delay0.40.41.2-1.10.4-0.10.50.7-0.1-0.1-0.20.9-1.0
Delay disc. indifference point, 16s delay1.11.11.91.4-1.3-0.9-1.4-1.31.1-0.9-0.6-0.70.5
Delay disc. indifference point, 2s delay0.20.20.7-0.5-0.2-0.5-0.20.40.3-0.4-0.30.8-0.8
Delay disc. indifference point, 24s delay0.40.30.80.20.20.70.3-0.1-0.60.70.8-0.80.9
Delay disc. indifference point, 4s delay0.80.81.6-0.1-0.9-1.0-0.8-0.00.9-0.9-1.31.0-1.0
Delay disc. indifference point, 8s delay0.70.71.30.8-1.1-1.0-1.1-0.61.0-1.0-0.7-0.2-0.1
Indifference point function ln k0.60.91.5-1.11.01.21.01.2-1.01.10.70.1-0.1
Indifference point function log k0.60.91.5-1.11.01.21.01.2-1.01.10.70.1-0.1
Patch foraging total patch changes 0 sec0.61.01.70.9-1.3-1.0-1.1-0.91.1-1.0-1.2-0.30.3
Patch foraging total patch changes 12 sec0.10.20.70.0-0.6-0.6-0.3-0.00.5-0.4-0.80.2-0.1
Patch foraging total patch changes 18 sec0.40.51.50.2-1.2-0.5-0.9-0.00.7-0.6-1.00.4-0.3
Patch foraging total patch changes 24 sec0.20.20.40.6-0.6-0.4-0.5-0.60.5-0.4-0.4-0.10.3
Patch foraging total patch changes 6 sec0.60.82.00.5-0.8-1.3-0.6-0.81.0-1.2-1.40.4-0.2
Patch foraging time to switch 0 sec0.00.10.3-0.00.00.00.1-0.2-0.20.10.4-0.50.5
Patch foraging water rate 0 sec0.30.51.40.5-0.5-0.9-0.6-0.40.9-0.9-1.20.5-0.4
Patch foraging water rate 12 sec0.10.20.80.9-0.0-0.1-0.2-0.80.2-0.1-0.1-0.30.5
Patch foraging water rate 18 sec0.71.03.71.5-0.5-0.8-0.5-1.90.8-0.6-0.7-0.70.8
Patch foraging water rate 24 sec0.10.10.40.10.1-0.1-0.20.10.2-0.2-0.70.6-0.4
Patch foraging water rate 6 sec0.60.82.21.50.30.10.2-1.2-0.10.20.4-1.51.5
Seeking ratio, delayed vs. immediate footshock3.03.46.12.0-2.5-2.0-2.3-1.62.2-2.2-1.6-0.10.1
Distance traveled before self-admin2.02.13.3-0.3-1.5-1.6-1.60.21.6-1.6-1.61.8-1.7
Distance traveled after self-admin0.20.30.8-0.3-0.4-0.2-0.40.30.4-0.3-0.60.9-0.7
Extensor digitorum longus weight0.10.41.50.9-0.2-0.6-0.1-1.20.4-0.5-0.0-0.60.7
Bone: elastic displacement1.01.11.80.11.31.21.3-0.0-1.11.21.1-1.01.0
Bone: elastic work1.21.62.7-1.61.61.41.61.5-1.31.40.60.4-0.4
Bone: endosteal estimation2.75.810.1-0.93.22.83.20.9-2.82.72.5-1.91.9
Bone: endosteal perimeter4.28.613.3-1.93.63.53.61.6-3.53.53.2-1.81.8
Epididymis fat weight2.96.910.1-3.23.03.02.82.9-2.93.02.50.5-0.4
Delta time in closed arm before/after self-admin0.80.82.2-1.50.50.30.31.3-0.20.10.11.3-1.3
Delta time in open arm before/after self-admin0.50.51.20.5-0.10.60.4-0.1-0.70.80.6-1.01.1
Diff in mean of infusions in LGA sessions0.70.81.20.5-1.1-1.0-1.0-0.81.0-1.1-0.90.4-0.3
Delay discount exponential model param0.30.30.5-0.40.70.70.60.4-0.70.70.50.00.2
Extinction: sum of active levers before priming0.30.30.6-0.2-0.4-0.7-0.30.00.6-0.8-0.50.6-0.5
Active lever presses in extinction session 60.20.20.6-0.30.1-0.3-0.00.30.3-0.5-0.40.8-0.7
Bone: final force0.61.03.2-1.80.20.40.21.6-0.10.2-0.71.2-1.3
Bone: final moment0.61.03.4-1.80.40.50.41.7-0.30.4-0.61.2-1.2
Food consumed during 24 hour testing period0.70.82.3-1.50.50.50.61.4-0.40.4-0.11.1-1.1
Glucose0.40.61.00.7-0.8-1.0-0.8-0.80.9-1.0-0.70.3-0.2
Heart weight1.11.54.4-2.00.60.50.62.1-0.50.3-0.41.5-1.6
Delay discount hyperbolic model param0.20.20.5-0.10.60.70.50.2-0.60.60.5-0.20.4
Intermittent access intake day 1-15 change0.40.40.70.7-0.6-0.8-0.7-0.40.8-0.9-0.5-0.20.1
Intermittent access intake escalation0.50.50.90.8-0.6-0.9-0.8-0.50.8-0.9-0.5-0.30.2
Intermittent access intake escalation 20.20.20.50.5-0.1-0.4-0.2-0.40.3-0.4-0.2-0.70.4
Intermitt. access day 1 inactive lever presses0.91.02.8-0.7-0.6-0.6-0.60.70.7-0.7-1.41.7-1.4
Intermitt. access day 15 inactive lever presses2.02.26.2-1.0-1.0-1.0-1.11.11.1-1.0-1.82.5-2.3
Intermitt. access escalation Index0.30.20.50.2-0.6-0.5-0.7-0.00.6-0.5-0.70.2-0.4
Intermittent access day 1 total infusions0.70.82.3-1.30.30.70.41.5-0.50.60.01.2-1.0
Intermittent access day 15 total infusions0.30.30.5-0.1-0.7-0.4-0.70.50.6-0.5-0.70.5-0.6
Intermittent access terminal intake (last 3 days)0.00.00.3-0.30.00.20.00.5-0.10.10.00.1-0.2
Intermittent access total infusions0.20.20.9-0.7-0.10.2-0.11.0-0.00.1-0.20.6-0.7
Intermittent access day 1 locomotion0.40.41.2-0.8-0.1-0.1-0.11.10.1-0.1-0.41.1-1.0
Intermittent access day 15 total locomotion0.10.10.4-0.4-0.00.3-0.00.7-0.20.2-0.00.3-0.2
Intermittent access total locomotion0.40.41.2-0.9-0.2-0.1-0.21.00.1-0.1-0.51.1-1.0
Intermittent access standard deviation0.50.51.3-1.0-0.3-0.1-0.31.10.2-0.2-0.51.0-1.2
Left kidney weight7.019.743.6-6.64.84.44.86.0-4.54.42.21.9-2.1
Right kidney weight7.120.048.0-6.94.74.04.76.3-4.34.21.82.7-2.7
Cocaine induced anxiety0.70.82.4-1.0-0.6-0.4-0.60.80.5-0.5-1.01.4-1.5
Post-drug Anxiety0.10.20.4-0.5-0.3-0.0-0.30.30.1-0.0-0.50.6-0.6
Baseline Anxiety0.70.71.91.30.0-0.00.1-1.20.0-0.00.5-1.41.4
Tail length0.10.41.40.90.30.00.1-0.8-0.20.20.5-1.21.1
Length with tail0.51.93.3-0.91.51.81.40.8-1.71.81.2-1.11.0
Length without tail0.61.33.1-1.81.01.51.11.4-1.31.40.5-0.0-0.0
Times rat made contact with spout0.40.41.4-0.90.1-0.00.20.8-0.0-0.2-0.31.2-1.1
Lifetime Intake0.80.92.1-1.2-0.4-0.1-0.41.50.2-0.1-0.71.4-1.5
Liver weight, left2.13.45.9-1.12.02.41.91.1-2.22.32.2-1.21.4
Liver weight, right3.35.57.7-2.02.72.72.71.9-2.72.72.8-1.21.2
Locomotor activity1.72.74.2-1.72.01.92.01.8-2.01.91.4-0.30.2
Locomotor testing distance0.00.10.20.10.20.10.00.1-0.10.10.2-0.50.4
Locomotor testing rearing1.21.83.6-1.61.71.41.41.9-1.41.31.30.2-0.3
Locomotion in novel chamber1.92.45.00.71.61.41.3-0.2-1.41.22.2-2.22.1
Locomotion in novel chamber post-restriction0.40.51.11.1-0.6-0.4-0.6-1.00.6-0.60.3-0.70.6
Fecal boli incidents, locomotor time 10.30.30.60.7-0.5-0.8-0.6-0.60.7-0.8-0.50.10.1
Change in fecal boli incidents, locomotor task2.01.93.7-0.61.21.91.30.8-1.81.91.5-1.11.0
Time >=10cm from walls, locomotor time 10.00.00.1-0.4-0.10.10.20.0-0.10.1-0.00.0-0.0
Bouts of movement, locomotor time 10.10.10.3-0.5-0.2-0.1-0.00.40.1-0.1-0.10.5-0.6
Total resting periods, locomotor time 10.40.50.9-0.3-0.8-0.7-0.70.20.7-0.7-0.70.8-0.9
Rest time, locomotor task time 11.41.53.4-0.8-1.0-1.2-1.00.61.1-1.2-1.21.8-1.8
Distance moved, locomotor task time 11.11.22.0-0.61.41.41.40.8-1.31.41.2-0.40.5
Vertical activity count, locomotor time 10.20.20.40.20.20.60.30.1-0.40.60.3-0.50.5
Time >=10cm from walls, locomotor time 20.10.10.40.2-0.00.10.1-0.6-0.00.10.2-0.50.4
Bouts of movement, locomotor time 20.80.92.3-0.5-0.8-0.7-0.70.90.7-0.7-1.01.4-1.5
Total resting periods, locomotor time 21.01.02.3-0.4-0.9-0.9-0.90.80.8-0.9-1.21.3-1.5
Rest time, locomotor task time 20.30.30.60.2-0.8-0.7-0.7-0.30.7-0.7-0.70.4-0.3
Distance moved, locomotor task time 20.91.11.7-1.01.31.21.31.0-1.11.21.10.3-0.2
Vertical activity count, locomotor time 20.50.61.1-0.50.91.00.90.4-0.91.00.8-0.00.1
Light reinforcement 10.91.62.2-0.41.41.31.50.4-1.41.41.4-1.41.4
Light reinforcement 20.50.71.2-1.01.10.81.10.8-1.00.90.9-0.2-0.1
Bone: marrow area2.86.010.6-1.03.32.83.20.9-2.82.82.5-1.91.9
Bone: maximum diameter3.36.18.8-2.93.02.93.02.7-2.82.81.9-0.00.0
Bone: maximum force1.22.06.1-2.51.01.01.02.2-0.80.8-0.21.6-1.5
Bone: maximum moment1.32.36.5-2.51.21.11.22.4-1.01.0-0.11.6-1.5
Mean time between licks in bursts0.30.51.00.7-0.9-0.6-0.9-1.00.6-0.7-0.1-0.30.4
Mean num. licks in bursts0.91.12.5-1.60.91.10.91.5-0.90.80.60.8-0.8
Cd content in liver0.70.81.4-0.91.20.81.20.9-1.10.91.1-0.00.1
Co content in liver0.10.20.6-0.80.10.00.10.5-0.0-0.0-0.20.6-0.6
Cu content in liver2.12.66.02.3-1.5-1.4-1.7-2.41.5-1.4-0.9-1.01.0
Fe content in liver0.50.50.90.10.90.90.90.0-0.70.80.7-0.80.8
K content in liver0.90.91.50.7-0.9-1.0-1.0-0.91.1-1.1-1.20.6-0.6
Mg content in liver1.71.82.90.8-1.5-1.5-1.6-1.21.6-1.5-1.70.6-0.6
Mn content in liver0.30.40.7-0.50.80.50.80.3-0.70.60.9-0.40.3
Na content in liver1.71.73.61.7-1.5-1.2-1.5-1.91.4-1.4-0.8-0.40.4
Rb content in liver0.00.00.1-0.0-0.1-0.1-0.30.10.2-0.2-0.40.1-0.1
Se content in liver0.20.30.80.9-0.2-0.1-0.2-0.90.1-0.00.2-0.60.6
Sr content in liver0.60.50.80.9-0.8-0.9-0.8-0.80.8-0.8-0.30.3-0.3
Zn content in liver0.70.82.11.4-0.3-0.2-0.3-1.40.2-0.10.2-1.31.3
Bone: minimum diameter1.22.34.0-1.22.01.91.90.9-1.81.81.5-0.80.7
Time in familiar zone, hab. session 10.20.20.3-0.40.50.50.40.1-0.40.50.5-0.00.0
Time in novel zone, hab. session 10.50.51.0-0.40.90.71.00.7-0.90.70.6-0.40.4
Total zone transitions, hab. session 11.41.96.32.5-0.8-0.5-0.8-2.40.6-0.50.1-1.61.7
Total locomotion distance, hab. session 11.42.05.31.80.70.50.8-1.8-0.60.61.2-2.22.3
Locomotion velocity, hab. session 11.11.54.42.00.2-0.10.3-2.1-0.0-0.00.6-1.81.9
Time in familiar zone, hab. session 20.80.81.8-0.31.00.71.0-0.3-0.80.91.4-1.11.1
Time in novel zone, hab. session 20.30.30.80.1-0.5-0.3-0.40.30.2-0.4-0.90.7-0.6
Total zone transitions, hab. session 20.40.51.71.3-0.7-0.4-0.6-1.10.5-0.4-0.5-0.30.3
Total locomotion distance, hab. session 20.30.41.41.2-0.6-0.6-0.5-1.00.6-0.7-0.50.00.0
Locomotion velocity, hab. session 20.60.82.51.6-0.8-0.9-0.7-1.40.8-0.9-0.6-0.10.1
Novel to familiar place preference ratio3.33.45.4-1.42.12.31.91.6-2.32.21.7-1.21.1
Novelty place preference4.34.36.9-1.72.42.52.21.9-2.62.51.9-1.21.1
Time in novel zone, NPP test4.95.18.1-2.02.62.72.52.1-2.82.72.0-1.11.1
Total zone transitions, NPP test1.11.65.62.4-0.8-0.4-0.7-2.30.5-0.30.1-1.31.2
Total locomotion distance, NPP test0.60.82.91.7-0.7-0.6-0.5-1.50.6-0.5-0.3-0.50.5
Locomotion velocity, NPP test0.91.24.42.1-0.9-0.8-0.8-2.00.8-0.8-0.2-0.70.6
Intraocular pressure0.50.71.6-0.90.81.30.70.8-1.01.20.90.1-0.1
Delta distance traveled before/after self-admin2.22.34.3-0.41.82.11.80.5-1.92.01.6-0.91.1
Delta ambulatory time before/after self-admin2.32.54.5-0.42.02.11.90.4-2.02.01.5-1.01.1
Parametrial fat weight0.20.30.8-0.7-0.2-0.4-0.20.60.4-0.4-0.50.8-0.9
Pavlov. Cond. lever latency1.31.73.0-1.31.21.71.21.0-1.61.61.4-0.70.8
Pavlov. Cond. magazine entry latency2.22.84.60.8-1.8-2.2-1.7-0.82.1-2.1-1.81.4-1.4
Pavlov. Cond. change in total contacts3.33.55.31.0-2.0-2.3-1.8-0.82.2-2.2-2.21.7-1.7
Pavlov. Cond. index score2.32.94.60.5-1.6-2.1-1.6-0.32.0-2.0-2.01.8-1.8
Pavlov. Cond. latency score1.92.43.90.6-1.5-2.0-1.4-0.31.9-1.9-1.81.6-1.6
Pavlov. Cond. lever contacts2.42.84.81.3-1.7-2.2-1.6-1.02.1-2.1-1.81.2-1.3
Pavlov. Cond. magazine entry number2.02.43.9-0.61.62.01.50.5-1.92.01.7-1.51.5
Pavlov. Cond. intertrial magazine entries0.60.81.61.3-1.1-0.7-1.1-1.00.8-0.8-0.8-0.50.4
Pavlov. Cond. lever-magazine prob. diff.2.22.74.30.7-1.7-2.1-1.6-0.52.0-2.0-1.91.6-1.6
Pavlov. Cond. response bias2.63.25.10.9-1.9-2.3-1.8-0.72.2-2.2-2.01.6-1.6
Pavlov. Cond. lever latency0.81.01.8-1.31.01.10.91.2-1.11.01.30.4-0.3
Pavlov. Cond. magazine entry latency4.65.49.42.2-3.1-2.4-3.0-2.02.6-2.5-2.70.1-0.5
Pavlov. Cond. change in total contacts1.82.57.00.8-1.8-1.7-1.8-0.71.8-1.7-2.60.5-0.8
Pavlov. Cond. index score2.83.75.81.9-2.4-2.0-2.3-1.72.2-2.1-2.4-0.1-0.2
Pavlov. Cond. latency score3.74.67.22.0-2.7-2.4-2.6-1.92.5-2.4-2.70.1-0.4
Pavlov. Cond. lever contacts0.91.32.61.2-1.1-1.3-1.1-1.21.3-1.2-1.6-0.30.1
Pavlov. Cond. magazine entry number2.83.46.4-1.62.51.92.41.3-2.11.92.4-0.20.5
Pavlov. Cond. intertrial magazine entries1.62.15.3-2.30.80.30.72.2-0.40.20.02.3-2.1
Pavlov. Cond. lever-magazine prob. diff.2.73.45.31.9-2.3-1.9-2.2-1.72.1-2.0-2.3-0.2-0.1
Pavlov. Cond. response bias1.41.93.91.3-1.6-1.4-1.6-1.11.6-1.4-2.0-0.1-0.2
Time in closed arm before self-admin4.24.77.92.8-2.0-2.6-2.1-2.82.3-2.4-1.7-1.31.0
Time in closed arm after self-admin0.20.20.5-0.60.7-0.30.40.40.1-0.3-0.00.4-0.7
Time in open arm before self-admin0.60.61.5-0.21.11.10.7-0.0-0.80.91.2-0.20.5
Time in open arm after self-admin0.80.91.90.60.21.10.5-0.4-0.91.21.2-1.11.4
Bone: periosteal estimation2.45.08.6-1.62.92.82.91.5-2.62.62.1-1.11.0
Bone: periosteal perimeter4.57.511.2-2.73.43.33.32.4-3.23.22.7-0.70.8
Bone: post-yield work0.40.51.6-0.8-0.1-0.2-0.10.70.3-0.3-0.71.3-1.2
Progressive ratio test 1 active lever presses0.80.82.7-0.7-0.6-0.2-0.71.00.4-0.2-0.71.6-1.6
Progressive ratio test 1 breakpoint0.50.51.8-0.6-0.4-0.1-0.50.80.3-0.1-0.41.3-1.3
Progressive ratio test 1 inactive lever presses2.62.86.8-0.9-1.4-1.4-1.41.01.5-1.5-1.92.6-2.4
Progressive ratio test 2 active lever presses1.01.01.6-0.2-1.3-0.9-1.20.31.0-0.9-1.21.2-1.1
Progressive ratio test 2 breakpoint1.31.42.7-0.3-1.3-1.1-1.20.51.2-1.1-1.41.6-1.6
Progressive ratio test 2 inactive lever presses2.52.94.30.2-2.1-1.7-2.0-0.01.9-1.8-2.11.8-1.6
Incentive Sensitization - Responses1.21.21.90.2-1.3-1.3-1.3-0.21.3-1.3-1.40.9-0.8
Incentive Sensitization - Breakpoint1.21.32.0-0.0-1.3-1.3-1.3-0.01.3-1.3-1.41.1-1.1
Sum of active levers in priming session hrs 5-60.20.20.50.2-0.4-0.7-0.3-0.10.5-0.7-0.50.3-0.2
Progressive ratio0.40.40.80.3-0.6-0.8-0.6-0.70.8-0.9-0.80.3-0.2
Food seeking constrained by brief footshock1.21.53.6-1.60.91.31.11.9-1.21.30.80.8-0.8
Seeking ratio, punishment vs. effort0.70.82.5-1.10.60.90.71.6-0.91.00.70.6-0.6
Retroperitoneal fat weight2.16.915.9-4.02.62.42.73.6-2.62.51.61.5-1.4
Reaction time number correct0.71.02.71.30.30.50.1-1.2-0.20.41.0-1.51.6
Reaction time mean minus median0.30.50.8-0.30.80.40.90.6-0.60.50.8-0.80.8
Reaction time mean minus median AUC0.50.61.7-0.90.90.60.91.3-0.80.70.8-0.20.2
Reaction time num false alarms1.01.32.9-0.01.40.81.3-0.4-0.80.91.3-1.71.6
Reaction time num false alarms AUC1.01.43.00.11.30.81.3-0.6-0.90.91.3-1.71.7
Reaction time trials correct on left0.71.02.71.30.30.50.1-1.2-0.20.41.0-1.51.6
Reaction time trials on left0.71.13.01.40.30.50.1-1.2-0.30.41.1-1.61.7
Reaction time mean0.10.10.20.4-0.4-0.3-0.3-0.30.2-0.3-0.1-0.40.4
Reaction time mean AUC0.10.10.10.4-0.3-0.3-0.4-0.20.3-0.3-0.1-0.20.2
Median of all reaction times0.20.30.60.6-0.7-0.5-0.8-0.60.6-0.6-0.4-0.20.1
Reaction time omissions0.20.20.70.60.00.20.1-0.5-0.10.10.5-0.90.7
Reaction time false alarm rate0.20.30.8-0.60.80.30.90.1-0.50.40.5-0.60.4
Reaction time premature initiation rate0.60.82.20.5-0.6-1.3-0.6-0.81.0-1.1-1.50.2-0.2
Reaction time premature initiations0.40.51.10.9-0.5-0.9-0.6-1.00.8-0.8-0.9-0.40.4
Std. dev. reaction times0.50.60.9-0.70.90.81.00.9-0.90.80.8-0.70.6
Reaction time trials completed0.71.13.01.40.30.50.1-1.2-0.30.41.1-1.61.7
Reaction time trials AUC0.60.92.61.20.40.50.2-1.1-0.30.51.0-1.51.6
Run reversals in cocaine runway, females1.11.02.60.90.60.70.7-1.2-0.60.71.2-1.41.6
Run reversals in cocaine runway, males1.91.94.0-0.71.42.01.51.1-1.71.81.6-0.40.6
Latency to leave start box in cocaine runway0.10.10.3-0.50.20.00.20.6-0.10.00.00.3-0.3
Latency to leave start box in cocaine runway, F0.10.10.40.6-0.2-0.4-0.2-0.50.3-0.4-0.1-0.40.3
Latency to leave start box in cocaine runway, M1.01.03.0-1.70.30.20.31.7-0.30.3-0.21.3-1.4
Std. dev. time between licks in bursts1.01.31.81.3-1.3-1.2-1.2-1.31.2-1.1-1.20.10.0
Total sessions with >9 infusions1.01.13.1-1.70.30.20.21.8-0.20.2-0.41.4-1.5
Short access day 1 total inactive lever presses0.70.82.4-1.40.40.50.41.6-0.40.4-0.41.0-1.1
Short access day 10 total inactive lever presses0.50.60.9-0.80.80.90.81.0-0.90.90.40.5-0.2
Short access day 1 total infusions1.11.23.4-1.80.30.20.21.8-0.20.2-0.51.4-1.6
Short access day 10 total infusions0.60.72.1-1.1-0.3-0.3-0.31.20.3-0.3-0.51.4-1.4
Short access total infusions1.92.15.9-2.1-0.3-0.2-0.32.20.2-0.2-0.92.3-2.4
Short access day 1 locomotion0.60.71.6-0.7-0.5-0.7-0.50.40.7-0.8-0.81.2-1.3
Short access day 10 total locomotion0.60.61.3-0.4-0.5-1.0-0.60.40.8-1.0-0.71.2-1.0
Short access total locomotion1.51.54.4-1.5-0.2-0.7-0.31.50.5-0.7-0.92.1-2.1
One hour access (0.3 mA shock)0.20.20.70.3-0.8-0.4-0.8-0.00.6-0.5-0.3-0.0-0.1
Compulsive drug intake1.01.02.41.5-1.0-0.6-1.0-1.40.7-0.6-0.3-1.21.0
One hour access (shock baseline)0.10.10.4-0.5-0.2-0.0-0.10.70.1-0.10.00.5-0.6
Social response proportion0.40.40.7-0.2-0.7-0.6-0.60.50.6-0.7-0.90.5-0.8
Social responses0.10.20.60.20.50.10.4-0.1-0.30.20.5-0.80.7
Social time1.82.44.31.5-1.7-2.1-1.7-1.41.9-2.0-1.30.3-0.3
Soleus weight0.20.40.70.4-0.7-0.6-0.7-0.80.8-0.6-0.80.5-0.5
Bone: stiffness0.71.23.6-1.90.50.50.61.8-0.40.4-0.21.4-1.3
Tibialis anterior weight0.72.54.01.4-2.0-2.0-2.0-1.71.8-1.8-1.50.4-0.3
Time to tail flick, vehicle, before self-admin0.40.41.00.10.80.51.0-0.2-0.60.50.5-0.70.7
Time to tail flick, vehicle, after self-admin1.81.94.91.30.90.81.0-1.2-1.00.91.5-2.12.2
Time to tail flick, test, before self-admin0.90.92.1-0.11.31.11.2-0.2-1.01.01.4-0.50.7
Time to tail flick, test, after self-admin0.70.71.91.2-0.5-0.5-0.6-1.40.5-0.6-0.1-1.21.0
Delta time to tail flick, vehicle, before/after SA0.10.10.30.4-0.5-0.4-0.5-0.30.4-0.4-0.2-0.00.1
Delta time to tail flick, test, before/after SA1.81.62.81.6-1.3-1.2-1.3-1.71.1-1.2-0.9-1.21.0
Tibia length0.61.62.8-1.71.21.61.21.5-1.41.60.7-0.40.4
Ambulatory time before self-admin1.41.52.5-0.2-1.3-1.4-1.30.21.3-1.3-1.31.6-1.4
Ambulatory time after self-admin0.10.10.30.6-0.4-0.1-0.4-0.60.3-0.2-0.2-0.10.4
Bone: tissue strength0.20.10.4-0.40.30.70.30.5-0.40.50.2-0.10.1
Total heroin consumption0.30.30.6-0.1-0.2-0.7-0.30.30.7-0.8-0.70.6-0.6
Bone: trabecular number0.30.40.80.10.40.80.40.1-0.50.70.9-0.80.9
Bone: trabecular spacing0.60.82.3-1.40.30.10.31.2-0.30.2-0.31.4-1.5
Bone: trabecular thickness0.10.10.30.6-0.2-0.1-0.2-0.50.3-0.2-0.1-0.30.4
Bone: trabecular tissue density1.52.13.51.6-1.5-1.7-1.5-1.51.8-1.9-1.6-0.00.0
Water consumed over 24 hours0.40.50.7-0.80.70.80.80.8-0.80.70.30.1-0.1
Number of responses in last shaping day3.43.56.30.9-2.0-2.5-2.0-0.82.4-2.5-2.21.2-1.2