Smg6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr10_60480197_60486585	0.04	0.04	3.8e-04	0	0.02	0.01	0.01	5.7e-02	7.8e-04	5.4e-03	9.2e-03
2	NAcc	intron excision ratio	chr10_60409506_60486585	0.04	0.03	4.2e-04	0	0.02	0.01	0.01	7.1e-02	9.8e-04	5.8e-03	1.2e-02
3	Adipose	isoform ratio	XM_063268674.1	0.04	0.03	1.7e-05	0.03	0.03	0.02	0.02	7.6e-04	6.3e-04	6.5e-03	2.7e-03
4	Adipose	alternative polyA	XM_063268674.1	0.03	0.02	1.5e-03	0.01	0.01	0	0.01	2.0e-02	7.5e-03	1.7e-01	2.3e-02
5	Adipose	alternative polyA	NM_001105808.1	0.03	0.02	2.2e-03	0.01	0.01	0	0.01	3.4e-02	1.3e-02	1.7e-01	3.7e-02
6	IL	mRNA stability	Smg6	0.17	0.11	1.3e-03	0.07	0.08	0.06	0.07	1.1e-02	4.9e-03	1.5e-02	1.1e-02
7	pVTA	gene expression	Smg6	0.05	0.05	1.0e-03	0.05	0.02	0.03	0.04	9.9e-05	9.2e-03	3.7e-03	4.5e-04
8	Liver	mRNA stability	Smg6	0.05	0.06	6.6e-03	0	0.01	0.01	0.01	9.6e-02	1.0e-02	5.0e-02	6.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	2.4	4.4	7.8	-2.8	2.8	2.5	2.0	-2.0	2.0	-1.3	0.1
Area under the delay curve	0.5	0.8	1.6	1.3	-1.3	-0.9	-0.7	0.7	-0.7	0.9	0.3
BMI with tail	0.7	2.6	4.4	-1.4	1.4	2.1	1.9	-1.8	1.8	-1.2	0.9
BMI without tail	0.3	1.5	4.6	-2.1	2.2	0.7	0.2	-0.2	0.1	1.0	-1.0
Body weight	0.9	4.1	10.6	-3.2	3.3	0.2	-0.6	0.7	-0.7	2.1	-2.5
Weight adjusted by age	0.4	1.3	2.1	-0.1	0.1	1.3	1.4	-1.4	1.3	-0.8	1.5
Bone surface	2.6	5.0	7.9	-2.3	2.3	2.8	2.4	-2.4	2.4	-1.8	0.8
Bone volume	2.6	5.2	8.1	-2.4	2.4	2.9	2.5	-2.5	2.4	-1.8	0.8
Breakpoint value in progressive ratio session	0.3	0.6	1.8	-1.3	1.4	0.5	0.2	-0.2	0.1	0.4	-0.6
Number of licking bursts	0.1	0.2	0.4	0.6	-0.6	-0.6	-0.4	0.4	-0.4	0.3	0.1
Context. condit. distance diff. score	0.7	0.8	1.8	-1.3	1.3	1.0	0.8	-0.8	0.8	-0.2	-0.0
Locomotion velocity, session 1	1.5	1.7	5.4	-2.3	2.3	1.0	0.5	-0.5	0.5	-0.0	-1.1
Locomotion distance, session 1	0.5	0.7	0.9	-0.9	0.9	1.0	0.8	-0.8	0.9	-1.0	0.1
Locomotion velocity, session 2	0.5	0.6	1.4	-1.2	1.2	0.8	0.6	-0.6	0.7	-0.6	-0.2
Locomotion distance, session 2	1.2	1.7	2.5	-1.4	1.4	1.6	1.4	-1.4	1.4	-1.3	0.3
Locomotion velocity, session 3	3.8	4.3	6.9	1.8	-1.8	-2.6	-2.4	2.4	-2.4	1.7	-1.2
Locomotion distance, session 3	0.1	0.1	0.2	0.3	-0.3	0.2	0.3	-0.3	0.3	-0.5	0.4
Stereotopy head waving bouts, day 3	0.4	0.5	1.2	-0.5	0.5	-0.6	-0.7	0.8	-0.7	0.7	-1.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.2	-0.1	-0.2	-0.1
Locomotion velocity, session 7	1.0	1.1	1.7	-0.5	0.5	1.3	1.3	-1.3	1.2	-1.0	0.9
Locomotion distance, session 7	1.7	2.2	3.4	-0.8	0.8	1.9	1.8	-1.8	1.7	-1.1	1.4
Stereotopy head waving bouts, day 7	0.6	0.7	2.3	-1.5	1.5	0.6	0.3	-0.3	0.4	-0.2	-0.8
Stereotopy head waving duration, day 7	0.9	1.1	2.3	-1.5	1.5	1.1	0.8	-0.8	0.8	-0.7	-0.4
Locomotion velocity, session 8	0.4	0.5	0.8	-0.7	0.7	0.8	0.7	-0.7	0.8	-0.9	0.2
Locomotion distance, session 8	1.2	1.8	4.4	-2.1	2.1	1.4	1.0	-1.0	1.0	-0.5	-0.3
Degree of sensitization distance	0.5	0.5	1.0	-1.0	1.0	0.9	0.7	-0.7	0.6	0.1	0.3
Degree of sensitization stereotypy	0.8	0.9	2.6	-1.6	1.6	0.8	0.5	-0.5	0.5	-0.3	-0.6
Conditioned locomotion	0.1	0.1	0.3	0.5	-0.5	-0.4	-0.3	0.3	-0.3	-0.3	-0.1
Cocaine response after cond. corrected	0.2	0.3	0.6	-0.6	0.6	-0.3	-0.5	0.5	-0.5	0.7	-0.8
Cocaine response after cond. not corrected	0.2	0.3	0.8	-0.9	0.9	-0.0	-0.2	0.2	-0.2	0.5	-0.8
Cocaine response before conditioning	0.6	0.7	1.1	-1.1	1.1	1.0	0.8	-0.8	0.8	-0.6	0.0
Saline control response	0.7	1.0	1.4	-0.2	0.2	1.2	1.2	-1.2	1.2	-1.0	1.0
Bone: connectivity density	3.9	6.3	9.4	-3.1	3.1	3.0	2.5	-2.5	2.5	-1.8	0.4
Bone: cortical apparent density	0.3	0.5	1.0	1.0	-1.0	0.1	0.4	-0.4	0.4	-0.7	1.0
Bone: cortical area	1.2	1.9	3.6	1.9	-1.9	-1.5	-1.2	1.2	-1.3	1.1	0.2
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.5	0.3	0.2	-0.2	0.2	0.1	-0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.1	0.1	-0.1	0.3	-0.1
Bone: cortical thickness	4.6	7.7	11.7	2.6	-2.6	-3.4	-3.1	3.1	-3.1	2.6	-1.1
Bone: cortical thickness	1.9	2.3	3.4	0.6	-0.6	-1.8	-1.8	1.8	-1.8	1.8	-1.2
Bone: cortical tissue density	0.2	0.4	0.7	0.7	-0.7	0.2	0.4	-0.4	0.4	-0.7	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	0.2	-0.2	-0.8	-0.8	0.8	-0.8	0.8	-0.7
Condit. Reinf. active-inactive response ratio	3.7	4.0	5.7	0.7	-0.7	-2.3	-2.4	2.4	-2.4	2.4	-1.8
Condit. Reinf. active responses	0.2	0.2	0.3	-0.4	0.4	0.6	0.5	-0.5	0.5	-0.4	0.3
Condit. Reinf. inactive responses	4.7	6.1	8.7	-0.7	0.7	2.8	2.9	-2.9	2.9	-2.8	2.3
Incentive salience index mean	0.5	0.7	1.2	-0.2	0.2	-0.8	-0.9	1.0	-0.9	1.0	-1.1
Condit. Reinf. lever presses	0.7	1.0	2.3	-1.2	1.2	-0.3	-0.7	0.7	-0.7	1.0	-1.5
Condit. Reinf. active minus inactive responses	0.5	0.7	1.1	-0.3	0.3	1.1	1.1	-1.0	1.0	-0.6	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.1	-0.1	-0.3	-0.3	0.3	-0.4	0.7	-0.1
Condit. Reinf. active responses	1.9	2.7	4.0	-0.3	0.3	2.0	2.0	-2.0	2.0	-1.6	1.8
Condit. Reinf. inactive responses	4.2	6.2	8.8	-0.4	0.3	2.8	3.0	-3.0	2.9	-2.9	2.5
Condit. Reinf. lever presses	0.8	1.2	2.2	0.9	-0.9	0.8	1.1	-1.1	1.1	-1.3	1.5
Condit. Reinf. lever reinforcers received	2.1	3.0	4.4	-0.2	0.2	2.0	2.1	-2.1	2.0	-1.7	2.0
Conditioned reinforcement - actives	0.6	2.3	3.5	-0.9	0.9	1.9	1.8	-1.8	1.8	-1.5	1.1
Conditioned reinforcement - inactives	0.2	0.6	0.9	-0.2	0.2	0.9	0.9	-0.9	0.9	-0.6	0.9
Conditioned locomotion	0.2	0.2	0.6	0.8	-0.8	0.1	0.2	-0.3	0.2	-0.4	0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.6	0.6	0.6	0.5	-0.4	0.5	-0.6	-0.1
Patch foraging indifference point AUC	0.3	0.7	1.8	0.9	-0.9	0.4	0.7	-0.7	0.7	-0.8	1.3
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.2	0.2	0.6	0.5	-0.5	0.5	-0.3	0.3
Delay disc. indifference point, 16s delay	0.6	0.8	2.2	1.5	-1.4	-0.7	-0.4	0.4	-0.5	0.7	0.9
Delay disc. indifference point, 2s delay	0.5	0.5	0.9	0.9	-0.9	-0.8	-0.7	0.6	-0.7	0.7	0.1
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	0.8	-0.7	-0.2	-0.1	0.1	-0.1	0.4	0.6
Delay disc. indifference point, 4s delay	0.5	0.6	1.1	0.7	-0.7	-0.9	-0.7	0.7	-0.8	1.0	-0.0
Delay disc. indifference point, 8s delay	0.3	0.6	0.8	0.9	-0.9	-0.8	-0.7	0.7	-0.7	0.9	0.1
Indifference point function ln k	0.2	0.6	1.7	-1.3	1.3	0.6	0.4	-0.4	0.4	-0.4	-0.6
Indifference point function log k	0.2	0.6	1.7	-1.3	1.3	0.6	0.4	-0.4	0.4	-0.4	-0.6
Patch foraging total patch changes 0 sec	0.1	0.4	0.6	-0.6	0.6	0.7	0.6	-0.6	0.6	-0.8	0.1
Patch foraging total patch changes 12 sec	0.4	0.5	0.8	0.4	-0.4	-0.9	-0.9	0.9	-0.8	0.5	-0.7
Patch foraging total patch changes 18 sec	0.2	0.4	0.6	0.6	-0.6	-0.7	-0.6	0.6	-0.6	0.8	-0.0
Patch foraging total patch changes 24 sec	0.1	0.3	0.8	0.9	-0.9	-0.6	-0.5	0.5	-0.5	0.2	0.1
Patch foraging total patch changes 6 sec	0.3	0.4	1.0	0.6	-0.6	0.4	0.6	-0.6	0.6	-1.0	0.8
Patch foraging time to switch 0 sec	0.8	3.2	4.6	0.0	-0.0	-1.9	-2.1	2.1	-2.1	2.2	-2.0
Patch foraging water rate 0 sec	0.4	1.5	2.7	0.3	-0.3	1.2	1.3	-1.4	1.4	-1.6	1.4
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.0	-0.0	0.2	0.2	-0.2	0.2	0.0	0.4
Patch foraging water rate 18 sec	1.4	3.1	4.7	-1.4	1.4	2.2	2.0	-2.0	2.0	-1.6	1.0
Patch foraging water rate 24 sec	0.4	0.5	0.8	0.0	-0.0	0.8	0.8	-0.8	0.9	-0.9	0.7
Patch foraging water rate 6 sec	0.2	0.3	0.7	0.8	-0.8	-0.0	0.2	-0.2	0.2	-0.4	0.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.9	1.4	-1.4	-0.3	0.1	-0.1	0.1	-0.4	1.0
Distance traveled before self-admin	1.0	2.3	5.8	2.4	-2.4	-1.5	-1.0	1.0	-1.1	0.6	0.7
Distance traveled after self-admin	0.2	0.3	0.8	0.9	-0.9	-0.5	-0.3	0.3	-0.3	0.4	0.4
Extensor digitorum longus weight	4.2	16.8	25.7	-3.5	3.4	5.1	4.6	-4.6	4.6	-4.1	1.9
Bone: elastic displacement	0.2	0.3	0.9	0.9	-0.9	-0.3	-0.1	0.0	-0.0	-0.3	0.5
Bone: elastic work	3.7	4.8	7.3	2.1	-2.1	-2.7	-2.5	2.4	-2.4	1.7	-1.0
Bone: endosteal estimation	0.3	0.7	1.1	-0.2	0.2	1.0	1.0	-1.0	1.0	-0.7	0.9
Bone: endosteal perimeter	1.5	3.6	5.3	-0.2	0.2	2.2	2.3	-2.3	2.3	-1.9	2.1
Epididymis fat weight	2.7	13.5	27.7	-5.3	5.3	4.3	3.4	-3.3	3.2	-1.2	0.1
Delta time in closed arm before/after self-admin	0.5	0.5	1.1	1.0	-1.0	0.0	0.3	-0.3	0.4	-0.6	1.0
Delta time in open arm before/after self-admin	0.3	0.4	1.1	-1.0	1.1	0.7	0.4	-0.4	0.3	0.0	-0.3
Diff in mean of infusions in LGA sessions	0.4	0.7	2.3	-1.5	1.5	0.5	0.2	-0.1	0.2	0.3	-0.8
Delay discount exponential model param	0.5	0.7	1.3	-1.2	1.1	0.9	0.7	-0.7	0.7	-0.9	-0.3
Extinction: sum of active levers before priming	1.9	2.8	4.4	-1.2	1.2	2.1	2.0	-2.0	1.9	-1.5	1.2
Active lever presses in extinction session 6	1.8	1.8	3.0	-1.3	1.3	1.7	1.5	-1.5	1.5	-1.0	0.7
Bone: final force	1.6	2.6	3.7	0.4	-0.4	-1.8	-1.9	1.9	-1.9	1.9	-1.6
Bone: final moment	1.2	2.0	2.9	0.5	-0.4	-1.6	-1.7	1.7	-1.7	1.6	-1.4
Food consumed during 24 hour testing period	0.1	0.2	0.4	-0.7	0.7	0.6	0.5	-0.4	0.4	-0.2	0.0
Glucose	2.1	3.3	7.3	2.7	-2.7	-2.0	-1.5	1.5	-1.5	1.1	0.4
Heart weight	0.7	1.1	3.6	-1.9	1.9	0.4	-0.0	0.0	-0.0	0.5	-1.3
Delay discount hyperbolic model param	0.7	0.9	1.4	-1.2	1.2	1.1	0.9	-0.9	0.9	-1.0	-0.1
Intermittent access intake day 1-15 change	0.3	1.7	3.7	1.4	-1.4	0.7	1.1	-1.1	1.1	-1.3	1.9
Intermittent access intake escalation	0.3	1.9	4.3	1.5	-1.5	0.8	1.2	-1.2	1.2	-1.4	2.1
Intermittent access intake escalation 2	0.8	1.3	2.6	1.4	-1.4	0.4	0.8	-0.8	0.8	-1.2	1.6
Intermitt. access day 1 inactive lever presses	0.1	1.5	4.8	2.2	-2.2	-0.5	-0.0	-0.0	0.0	-0.6	1.4
Intermitt. access day 15 inactive lever presses	0.3	1.6	3.7	1.9	-1.9	0.0	0.5	-0.6	0.6	-1.0	1.9
Intermitt. access escalation Index	0.6	1.8	3.5	-1.2	1.2	-0.8	-1.2	1.2	-1.2	1.7	-1.9
Intermittent access day 1 total infusions	0.0	0.1	0.5	0.3	-0.2	0.2	0.3	-0.3	0.3	-0.1	0.7
Intermittent access day 15 total infusions	0.8	1.9	3.9	0.7	-0.7	1.3	1.5	-1.5	1.5	-1.4	2.0
Intermittent access terminal intake (last 3 days)	0.9	1.5	2.2	-0.1	0.1	1.4	1.5	-1.5	1.5	-1.3	1.4
Intermittent access total infusions	0.9	1.1	2.6	0.5	-0.5	1.0	1.2	-1.2	1.1	-0.9	1.6
Intermittent access day 1 locomotion	0.1	0.2	0.3	0.6	-0.5	-0.4	-0.3	0.3	-0.4	0.5	0.3
Intermittent access day 15 total locomotion	0.1	0.5	1.4	1.0	-1.0	0.2	0.4	-0.4	0.4	-0.4	1.2
Intermittent access total locomotion	0.4	0.5	1.4	0.7	-0.7	0.4	0.6	-0.6	0.5	-0.5	1.2
Intermittent access standard deviation	0.8	4.3	8.8	1.3	-1.4	1.7	2.1	-2.2	2.1	-2.4	3.0
Left kidney weight	1.2	9.8	14.2	1.2	-1.2	-3.7	-3.7	3.7	-3.7	3.8	-2.6
Right kidney weight	1.4	9.6	15.7	0.6	-0.6	-3.5	-3.6	3.6	-3.7	4.0	-2.8
Cocaine induced anxiety	0.0	0.1	0.2	0.4	-0.4	0.0	0.1	-0.1	0.2	-0.3	0.3
Post-drug Anxiety	0.5	0.6	1.6	-1.1	1.1	-0.2	-0.5	0.5	-0.4	0.5	-1.3
Baseline Anxiety	0.5	0.8	2.3	-1.5	1.5	0.1	-0.2	0.2	-0.2	0.5	-1.2
Tail length	1.3	6.8	13.0	-2.5	2.6	-1.5	-2.2	2.2	-2.3	3.3	-3.6
Length with tail	2.0	9.0	16.4	-2.4	2.4	-2.1	-2.8	2.9	-2.9	3.9	-4.0
Length without tail	0.3	1.7	3.3	-1.7	1.7	-0.5	-0.9	0.9	-0.9	1.5	-1.8
Times rat made contact with spout	1.8	2.1	2.9	0.6	-0.5	-1.7	-1.7	1.7	-1.7	1.7	-1.2
Lifetime Intake	0.7	0.9	2.1	0.4	-0.4	0.9	1.0	-1.0	1.0	-0.8	1.4
Liver weight, left	3.2	5.6	10.4	-3.2	3.2	-0.6	-1.4	1.4	-1.5	2.7	-3.2
Liver weight, right	2.0	3.6	8.8	-2.9	3.0	0.0	-0.7	0.7	-0.8	2.0	-2.3
Locomotor activity	0.1	0.2	0.4	-0.1	0.1	0.5	0.5	-0.5	0.4	-0.1	0.6
Locomotor testing distance	0.0	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3	0.3	-0.2	0.2
Locomotor testing rearing	0.4	1.3	2.0	-0.1	0.1	1.3	1.4	-1.4	1.4	-1.2	1.3
Locomotion in novel chamber	2.1	2.8	5.5	2.2	-2.2	0.5	1.1	-1.1	1.1	-1.9	2.3
Locomotion in novel chamber post-restriction	0.2	0.6	1.2	-0.2	0.2	0.9	0.9	-0.9	0.9	-1.1	0.6
Fecal boli incidents, locomotor time 1	0.1	0.3	0.7	-0.3	0.3	-0.4	-0.5	0.5	-0.5	0.4	-0.8
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.3	-0.3	-0.9	-0.9	0.9	-0.9	0.8	-0.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.3	0.3	0.4	0.4	-0.4	0.4	-0.6	0.1
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.3	0.3	0.2	0.1	-0.1	0.1	-0.1	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3	0.3	-0.3	0.1
Rest time, locomotor task time 1	0.1	0.1	0.3	0.6	-0.6	-0.2	-0.0	-0.0	0.0	-0.3	0.3
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.1	0.1	0.4	0.4	-0.4	0.4	-0.4	0.4
Vertical activity count, locomotor time 1	0.1	0.6	1.0	-0.8	0.8	1.0	0.9	-0.8	0.8	-0.8	0.2
Time >=10cm from walls, locomotor time 2	0.2	0.4	0.7	0.8	-0.8	-0.7	-0.6	0.6	-0.7	0.6	-0.0
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.1	-0.2	0.4	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.2	0.1	-0.1	0.1	0.1	0.1
Rest time, locomotor task time 2	0.2	0.3	0.6	0.1	-0.1	0.6	0.7	-0.7	0.6	-0.5	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.4	0.5	-0.5	0.3	0.4	-0.4	0.4	-0.7	0.6
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.1	-0.1	-0.6	-0.6	0.6	-0.6	0.3	-0.6
Light reinforcement 1	0.0	0.1	0.1	-0.1	0.1	0.3	0.3	-0.3	0.3	-0.2	0.2
Light reinforcement 2	1.2	2.7	4.2	1.1	-1.1	-2.0	-1.9	1.9	-1.9	1.7	-1.0
Bone: marrow area	0.3	0.6	1.0	-0.2	0.2	1.0	1.0	-1.0	1.0	-0.7	0.9
Bone: maximum diameter	0.5	1.0	2.4	0.8	-0.8	0.8	1.0	-1.0	1.0	-0.9	1.5
Bone: maximum force	1.2	2.4	3.5	0.7	-0.7	-1.8	-1.8	1.8	-1.9	1.8	-1.3
Bone: maximum moment	0.9	1.8	2.5	0.7	-0.7	-1.6	-1.6	1.6	-1.6	1.4	-1.0
Mean time between licks in bursts	0.1	0.6	1.1	-0.7	0.7	-0.5	-0.7	0.7	-0.7	0.9	-1.1
Mean num. licks in bursts	0.2	0.6	1.0	-0.2	0.3	-0.6	-0.8	0.8	-0.8	1.0	-1.0
Cd content in liver	2.2	2.4	4.2	0.1	-0.1	1.7	1.9	-1.9	1.8	-1.5	2.0
Co content in liver	0.1	0.1	0.3	0.5	-0.5	-0.2	-0.1	0.1	-0.2	0.2	0.3
Cu content in liver	0.5	0.6	1.1	1.0	-1.0	-0.9	-0.8	0.8	-0.8	0.6	-0.0
Fe content in liver	0.6	0.7	1.5	-0.8	0.8	-0.5	-0.7	0.8	-0.7	0.9	-1.2
K content in liver	1.4	1.4	2.3	-0.4	0.4	-1.1	-1.3	1.3	-1.3	1.4	-1.5
Mg content in liver	0.2	0.2	0.3	0.0	-0.0	0.5	0.6	-0.6	0.6	-0.5	0.5
Mn content in liver	0.6	0.6	1.3	-0.4	0.4	0.9	0.9	-0.9	0.9	-1.1	0.4
Na content in liver	2.1	2.3	3.4	1.4	-1.4	-1.9	-1.7	1.7	-1.7	1.6	-0.7
Rb content in liver	3.5	4.1	6.4	-1.3	1.3	2.5	2.4	-2.4	2.4	-1.9	1.4
Se content in liver	0.4	0.5	0.8	0.6	-0.6	-0.9	-0.8	0.8	-0.8	0.6	-0.4
Sr content in liver	1.4	1.2	1.8	-0.7	0.7	1.3	1.3	-1.3	1.3	-1.3	0.6
Zn content in liver	0.2	0.2	0.5	-0.6	0.6	-0.1	-0.3	0.3	-0.3	0.5	-0.7
Bone: minimum diameter	0.6	1.2	1.9	1.0	-0.9	-1.3	-1.1	1.1	-1.2	1.4	-0.2
Time in familiar zone, hab. session 1	1.7	1.8	3.4	-0.2	0.2	1.5	1.6	-1.6	1.6	-1.8	1.3
Time in novel zone, hab. session 1	1.4	1.5	2.9	0.2	-0.2	-1.4	-1.4	1.4	-1.5	1.7	-1.1
Total zone transitions, hab. session 1	2.7	3.7	5.3	-0.7	0.7	2.2	2.3	-2.3	2.3	-2.2	1.7
Total locomotion distance, hab. session 1	0.7	1.0	1.4	-0.6	0.6	1.2	1.2	-1.2	1.2	-1.1	0.8
Locomotion velocity, hab. session 1	0.8	1.1	1.6	-0.6	0.6	1.2	1.2	-1.2	1.3	-1.2	0.7
Time in familiar zone, hab. session 2	1.8	2.0	3.0	-0.9	0.9	1.7	1.7	-1.7	1.7	-1.4	1.0
Time in novel zone, hab. session 2	4.1	4.4	6.7	1.4	-1.4	-2.6	-2.5	2.5	-2.5	2.1	-1.4
Total zone transitions, hab. session 2	0.8	1.0	1.4	-1.1	1.1	1.2	1.0	-1.0	1.0	-0.9	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.6	0.6	0.0	-0.1	0.1	-0.1	-0.1	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.5	0.5	-0.0	-0.1	0.1	-0.1	-0.1	-0.5
Novel to familiar place preference ratio	0.3	0.4	0.8	0.8	-0.8	0.2	0.4	-0.4	0.4	-0.6	0.9
Novelty place preference	0.1	0.1	0.2	0.5	-0.5	0.0	0.1	-0.1	0.1	-0.3	0.4
Time in novel zone, NPP test	0.0	0.1	0.1	0.2	-0.2	0.2	0.2	-0.2	0.2	-0.3	0.3
Total zone transitions, NPP test	1.4	2.1	3.0	-0.8	0.7	1.7	1.7	-1.7	1.7	-1.7	1.1
Total locomotion distance, NPP test	0.7	1.0	1.7	0.1	-0.1	1.0	1.1	-1.1	1.1	-1.3	1.1
Locomotion velocity, NPP test	0.7	1.0	1.8	0.6	-0.6	0.8	1.0	-1.0	1.0	-1.4	1.3
Intraocular pressure	2.2	3.6	8.0	1.4	-1.4	1.5	1.9	-1.9	1.9	-2.0	2.8
Delta distance traveled before/after self-admin	1.0	1.1	3.0	-1.7	1.7	1.1	0.7	-0.7	0.7	-0.2	-0.4
Delta ambulatory time before/after self-admin	0.6	1.1	2.9	-1.7	1.7	1.1	0.7	-0.7	0.7	-0.3	-0.5
Parametrial fat weight	3.7	8.7	24.2	-4.9	4.9	2.9	1.9	-1.8	1.8	-0.5	-1.4
Pavlov. Cond. lever latency	0.5	0.7	1.4	0.1	-0.1	0.8	0.9	-0.9	1.0	-1.2	0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	-0.8	0.9	-0.4	-0.7	0.7	-0.7	0.9	-1.2
Pavlov. Cond. change in total contacts	0.5	0.6	0.8	0.6	-0.6	-0.9	-0.8	0.8	-0.8	0.9	-0.3
Pavlov. Cond. index score	0.7	0.9	1.9	-0.9	0.9	-0.6	-0.9	0.9	-0.9	1.2	-1.4
Pavlov. Cond. latency score	1.1	1.4	2.6	-0.9	0.9	-0.8	-1.1	1.1	-1.2	1.5	-1.6
Pavlov. Cond. lever contacts	0.5	0.7	1.4	-0.1	0.1	-0.8	-0.9	0.9	-0.9	1.2	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	-0.5	0.1	0.2	-0.2	0.2	-0.4	0.5
Pavlov. Cond. intertrial magazine entries	1.4	1.6	2.5	0.3	-0.3	1.3	1.5	-1.5	1.5	-1.5	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.5	-0.8	0.8	-0.5	-0.7	0.7	-0.7	1.0	-1.2
Pavlov. Cond. response bias	0.3	0.3	0.7	-0.7	0.7	-0.2	-0.4	0.4	-0.4	0.7	-0.8
Pavlov. Cond. lever latency	0.6	0.8	2.5	-1.6	1.6	0.7	0.3	-0.3	0.3	-0.1	-0.8
Pavlov. Cond. magazine entry latency	1.1	1.6	2.3	0.8	-0.8	-1.5	-1.4	1.4	-1.5	1.4	-0.7
Pavlov. Cond. change in total contacts	0.3	0.8	1.8	1.3	-1.3	-0.9	-0.7	0.7	-0.7	0.6	0.3
Pavlov. Cond. index score	0.7	1.2	3.2	1.8	-1.8	-1.0	-0.6	0.6	-0.6	0.4	0.7
Pavlov. Cond. latency score	0.8	1.3	3.7	1.9	-1.9	-1.0	-0.7	0.6	-0.7	0.4	0.7
Pavlov. Cond. lever contacts	0.3	0.5	1.2	1.1	-1.1	-0.6	-0.4	0.4	-0.5	0.4	0.4
Pavlov. Cond. magazine entry number	1.2	1.5	2.3	-1.1	1.1	1.5	1.4	-1.4	1.4	-1.2	0.5
Pavlov. Cond. intertrial magazine entries	1.2	2.7	4.2	-1.3	1.3	2.0	1.9	-1.9	1.9	-1.6	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	3.1	1.7	-1.7	-0.9	-0.6	0.6	-0.6	0.4	0.7
Pavlov. Cond. response bias	0.7	0.9	1.7	1.3	-1.3	-1.1	-0.8	0.8	-0.9	0.9	0.2
Time in closed arm before self-admin	0.8	1.4	4.0	-2.0	2.0	0.3	-0.2	0.2	-0.2	0.4	-1.7
Time in closed arm after self-admin	0.4	0.4	0.7	0.3	-0.3	-0.8	-0.8	0.8	-0.7	0.6	-0.6
Time in open arm before self-admin	1.8	2.1	5.8	2.4	-2.4	-1.4	-0.9	0.8	-0.9	0.7	1.0
Time in open arm after self-admin	0.6	0.7	1.9	1.4	-1.4	-0.0	0.3	-0.3	0.2	-0.0	1.3
Bone: periosteal estimation	0.1	0.3	0.8	0.9	-0.9	-0.5	-0.4	0.4	-0.5	0.6	0.3
Bone: periosteal perimeter	0.2	0.4	1.3	0.9	-0.8	0.3	0.5	-0.5	0.4	-0.3	1.1
Bone: post-yield work	0.2	0.3	1.0	-1.0	1.0	0.2	-0.0	0.1	-0.1	0.4	-0.7
Progressive ratio test 1 active lever presses	0.4	0.7	2.2	0.8	-0.8	0.5	0.8	-0.8	0.7	-0.5	1.5
Progressive ratio test 1 breakpoint	0.5	0.8	2.4	0.7	-0.7	0.6	0.9	-0.9	0.8	-0.6	1.6
Progressive ratio test 1 inactive lever presses	0.4	1.1	3.4	1.8	-1.8	-0.5	-0.1	0.1	-0.1	-0.4	1.2
Progressive ratio test 2 active lever presses	2.1	3.0	6.2	0.5	-0.5	1.7	2.0	-2.0	1.9	-1.6	2.5
Progressive ratio test 2 breakpoint	2.4	3.0	6.1	0.4	-0.4	1.8	2.0	-2.0	1.9	-1.6	2.5
Progressive ratio test 2 inactive lever presses	0.6	2.1	5.7	1.2	-1.2	1.0	1.4	-1.4	1.3	-1.2	2.4
Incentive Sensitization - Responses	1.1	3.0	5.1	0.1	-0.1	1.8	2.1	-2.1	2.0	-1.7	2.3
Incentive Sensitization - Breakpoint	1.1	2.5	4.2	0.1	-0.1	1.7	1.9	-1.9	1.8	-1.6	2.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.3	-1.5	1.5	1.0	0.7	-0.7	0.6	0.2	-0.1
Progressive ratio	0.1	0.3	0.8	0.4	-0.4	0.3	0.4	-0.4	0.5	-0.9	0.5
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.2	-0.1
Seeking ratio, punishment vs. effort	0.4	1.0	1.5	0.4	-0.4	-1.2	-1.2	1.2	-1.2	1.2	-0.8
Retroperitoneal fat weight	0.1	0.5	0.8	-0.8	0.8	0.9	0.8	-0.8	0.8	-0.1	0.5
Reaction time number correct	0.0	0.0	0.1	-0.3	0.3	0.2	0.2	-0.2	0.1	-0.1	-0.1
Reaction time mean minus median	0.0	0.2	0.4	0.2	-0.2	0.3	0.4	-0.4	0.5	-0.7	0.4
Reaction time mean minus median AUC	0.2	1.6	2.5	-0.5	0.5	1.5	1.5	-1.5	1.5	-1.6	0.9
Reaction time num false alarms	1.1	2.0	3.6	0.6	-0.6	1.2	1.5	-1.5	1.5	-1.9	1.7
Reaction time num false alarms AUC	0.7	1.7	3.3	0.6	-0.6	1.1	1.4	-1.4	1.4	-1.8	1.6
Reaction time trials correct on left	0.0	0.0	0.1	-0.3	0.3	0.2	0.2	-0.2	0.1	-0.1	-0.1
Reaction time trials on left	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	-0.2	0.2	-0.2	-0.0
Reaction time mean	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.1	-0.1	0.2	-0.1
Reaction time mean AUC	0.0	0.1	0.2	0.5	-0.5	-0.2	-0.0	0.0	-0.0	-0.1	0.2
Median of all reaction times	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.4	0.4	-0.4	0.5	-0.2
Reaction time omissions	0.0	0.1	0.2	-0.4	0.4	0.2	0.1	-0.1	0.1	-0.1	-0.3
Reaction time false alarm rate	0.9	1.2	2.5	0.5	-0.5	0.9	1.1	-1.2	1.2	-1.6	1.3
Reaction time premature initiation rate	0.4	0.7	1.0	-0.7	0.7	1.0	0.9	-0.9	0.9	-0.7	0.4
Reaction time premature initiations	0.3	0.9	1.3	-0.8	0.8	1.2	1.1	-1.1	1.1	-0.9	0.5
Std. dev. reaction times	0.0	0.1	0.4	0.1	-0.1	0.3	0.3	-0.4	0.4	-0.7	0.2
Reaction time trials completed	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	-0.2	0.2	-0.2	-0.0
Reaction time trials AUC	0.0	0.0	0.1	-0.2	0.2	0.3	0.2	-0.2	0.2	-0.2	0.0
Run reversals in cocaine runway, females	0.4	0.5	1.0	0.4	-0.4	0.5	0.7	-0.7	0.8	-1.0	0.8
Run reversals in cocaine runway, males	1.2	1.4	2.0	0.1	-0.1	1.2	1.4	-1.4	1.4	-1.4	1.4
Latency to leave start box in cocaine runway	0.2	0.3	0.6	0.0	-0.0	-0.6	-0.7	0.7	-0.6	0.5	-0.7
Latency to leave start box in cocaine runway, F	0.9	1.1	2.8	-0.6	0.6	-0.9	-1.2	1.2	-1.1	0.9	-1.7
Latency to leave start box in cocaine runway, M	0.2	0.1	0.4	0.5	-0.5	0.2	0.3	-0.3	0.3	-0.2	0.7
Std. dev. time between licks in bursts	0.1	0.3	0.4	-0.4	0.4	0.6	0.6	-0.6	0.6	-0.7	0.3
Total sessions with >9 infusions	0.9	1.1	2.6	0.5	-0.5	1.0	1.2	-1.2	1.1	-1.0	1.6
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.0	-0.0	0.3	0.3	-0.3	0.3	-0.2	0.3
Short access day 10 total inactive lever presses	0.1	0.5	1.6	1.2	-1.2	-0.7	-0.5	0.4	-0.5	0.0	0.3
Short access day 1 total infusions	0.5	1.0	2.5	1.2	-1.2	0.4	0.7	-0.7	0.7	-0.9	1.6
Short access day 10 total infusions	1.0	1.7	4.6	1.0	-1.0	1.0	1.3	-1.3	1.2	-1.1	2.2
Short access total infusions	0.6	0.8	2.3	1.1	-1.1	0.4	0.7	-0.7	0.7	-0.7	1.5
Short access day 1 locomotion	0.7	1.1	3.4	1.8	-1.8	-0.3	0.1	-0.1	0.1	-0.2	1.5
Short access day 10 total locomotion	0.2	0.8	2.1	1.5	-1.5	-0.2	0.2	-0.2	0.1	-0.4	1.2
Short access total locomotion	1.0	1.5	4.2	2.0	-2.0	-0.2	0.3	-0.3	0.2	-0.5	1.7
One hour access (0.3 mA shock)	1.7	2.1	3.0	-0.3	0.3	1.7	1.7	-1.7	1.7	-1.5	1.6
Compulsive drug intake	0.8	1.2	2.9	-1.5	1.5	-0.3	-0.7	0.7	-0.6	0.9	-1.7
One hour access (shock baseline)	0.5	1.2	3.2	0.8	-0.8	0.9	1.1	-1.1	1.1	-1.0	1.8
Social response proportion	1.8	2.2	5.0	-2.2	2.2	-0.2	-0.7	0.8	-0.7	1.2	-2.2
Social responses	0.9	1.2	3.9	-2.0	2.0	0.7	0.2	-0.2	0.2	0.2	-1.1
Social time	1.3	2.0	6.4	-2.5	2.5	0.9	0.3	-0.3	0.4	-0.2	-1.6
Soleus weight	1.5	4.3	13.4	-3.7	3.7	1.7	0.9	-0.9	0.9	0.3	-1.4
Bone: stiffness	0.5	0.9	2.0	-1.4	1.4	-0.1	-0.4	0.4	-0.5	1.0	-1.3
Tibialis anterior weight	6.0	20.6	31.4	-4.8	4.8	5.6	4.9	-4.8	4.8	-3.9	1.3
Time to tail flick, vehicle, before self-admin	3.3	4.1	6.9	-2.6	2.6	2.4	2.0	-1.9	2.0	-1.4	0.0
Time to tail flick, vehicle, after self-admin	0.1	0.3	0.6	-0.8	0.8	0.5	0.4	-0.4	0.4	-0.3	-0.3
Time to tail flick, test, before self-admin	1.1	1.2	3.7	-1.7	1.6	-0.1	-0.5	0.5	-0.4	0.2	-1.9
Time to tail flick, test, after self-admin	0.5	0.5	0.8	-0.1	0.1	-0.7	-0.8	0.8	-0.8	0.8	-0.9
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.4	1.2	-1.2	-0.7	-0.5	0.5	-0.5	0.0	0.2
Delta time to tail flick, test, before/after SA	0.7	0.9	2.7	1.2	-1.2	0.3	0.6	-0.6	0.6	-0.5	1.6
Tibia length	1.6	4.4	7.2	-0.8	0.8	-2.0	-2.3	2.3	-2.3	2.6	-2.7
Ambulatory time before self-admin	1.1	3.5	5.7	2.4	-2.4	-2.2	-1.8	1.8	-1.8	1.4	0.0
Ambulatory time after self-admin	0.6	0.9	1.7	0.1	-0.1	-1.1	-1.1	1.1	-1.2	1.3	-0.9
Bone: tissue strength	1.8	1.9	2.9	1.1	-1.1	-1.7	-1.6	1.6	-1.6	1.2	-0.8
Total heroin consumption	2.2	2.6	6.6	-2.6	2.6	1.7	1.2	-1.2	1.2	-0.3	-0.4
Bone: trabecular number	2.6	5.0	8.1	-2.8	2.8	2.7	2.2	-2.2	2.2	-1.5	0.2
Bone: trabecular spacing	0.4	0.5	1.6	1.3	-1.3	-0.5	-0.3	0.3	-0.3	0.2	0.6
Bone: trabecular thickness	0.3	0.4	1.0	-1.0	1.0	0.5	0.4	-0.4	0.4	-0.4	-0.4
Bone: trabecular tissue density	1.0	1.8	3.1	1.8	-1.8	-1.6	-1.3	1.3	-1.3	0.8	-0.1
Water consumed over 24 hours	1.0	1.9	2.7	-0.2	0.2	-1.5	-1.6	1.6	-1.6	1.6	-1.6
Number of responses in last shaping day	1.0	1.3	3.8	1.9	-1.9	-0.1	0.3	-0.3	0.3	-0.4	1.7