Smg1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr1_181954419_181977476	0.05	0.03	4.2e-03	0.01	0.01	0.01	0.01	2.2e-02	4.9e-02	6.6e-02	3.5e-02
2	IL	intron excision ratio	chr1_181954419_181977476	0.28	0.16	2.1e-03	0.02	0.01	0.01	0.03	9.8e-02	1.4e-01	1.7e-01	5.9e-02
3	IL	intron excision ratio	chr1_181949766_181977476	0.27	0.14	3.7e-03	0.05	0.03	-0.01	0.05	2.8e-02	7.2e-02	8.3e-01	3.0e-02
4	Brain	gene expression	Smg1	0.12	0.07	5.9e-06	0.07	0.06	0.06	0.07	1.9e-07	3.0e-06	4.7e-06	6.7e-07
5	Adipose	gene expression	Smg1	0.05	0.03	3.6e-04	0	0.02	0	0	2.2e-01	2.2e-03	8.3e-02	8.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.1	1.9	3.8	1.1	2.0	-1.3	1.5	-0.5
Area under the delay curve	0.6	0.7	1.2	-0.8	-0.3	1.0	1.1	0.6
BMI with tail	3.6	12.4	24.5	4.9	4.1	-4.3	0.6	-1.3
BMI without tail	5.2	16.0	27.7	5.3	5.0	-4.8	1.4	-1.6
Body weight	3.1	13.7	23.3	4.3	4.8	-4.7	1.2	-1.8
Weight adjusted by age	1.1	1.6	4.9	1.1	-0.1	-1.0	-2.2	-1.1
Bone surface	0.6	1.1	1.8	1.2	1.3	-1.0	1.1	0.1
Bone volume	1.1	2.0	3.6	1.5	1.9	-1.3	1.5	-0.2
Breakpoint value in progressive ratio session	1.2	1.4	2.1	-1.2	-1.4	0.8	-1.5	-0.9
Number of licking bursts	3.4	5.5	9.2	-2.7	-2.7	3.0	-0.2	1.8
Context. condit. distance diff. score	0.2	0.3	0.6	-0.2	-0.4	-0.2	-0.8	-0.8
Locomotion velocity, session 1	0.6	0.7	0.9	-0.9	-0.2	1.0	1.0	0.9
Locomotion distance, session 1	0.6	0.8	1.2	0.6	1.1	-1.1	0.3	-1.0
Locomotion velocity, session 2	1.0	1.1	2.2	-1.5	-0.6	1.3	0.9	0.8
Locomotion distance, session 2	0.5	0.7	1.5	0.8	1.2	-0.7	1.1	0.0
Locomotion velocity, session 3	0.1	0.1	0.1	0.4	0.3	-0.4	-0.1	-0.1
Locomotion distance, session 3	0.5	0.5	1.0	0.7	-0.7	0.5	-0.5	1.0
Stereotopy head waving bouts, day 3	0.3	0.3	0.8	-0.9	0.1	-0.2	-0.1	-0.9
Stereotopy head waving duration, day 3	0.3	0.3	0.9	-0.6	0.4	-0.3	0.3	-0.9
Locomotion velocity, session 7	0.7	0.8	1.6	1.3	-0.8	0.4	-0.8	0.9
Locomotion distance, session 7	0.6	0.8	1.9	-0.1	-0.9	1.2	0.2	1.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.7	0.2	0.4	-0.4	-0.0	-0.8
Stereotopy head waving duration, day 7	1.3	1.5	2.8	1.7	1.2	-1.5	-0.2	-1.1
Locomotion velocity, session 8	0.1	0.1	0.3	-0.4	-0.2	0.5	0.4	0.0
Locomotion distance, session 8	0.1	0.1	0.3	0.2	0.3	-0.3	0.2	-0.5
Degree of sensitization distance	0.6	0.6	1.0	-1.0	0.7	-0.2	1.0	-0.7
Degree of sensitization stereotypy	0.3	0.4	1.2	1.1	0.6	-0.5	0.2	-0.3
Conditioned locomotion	0.8	1.0	2.2	-0.2	-1.5	1.1	-1.0	0.7
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.7	-0.4	0.7	0.2	0.5
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.3	0.2	-0.0	0.4	0.5
Cocaine response before conditioning	1.3	1.6	4.6	2.1	1.2	-1.1	0.4	0.6
Saline control response	0.2	0.2	0.5	0.3	0.4	-0.5	-0.1	-0.7
Bone: connectivity density	0.5	0.8	1.7	1.3	1.0	-1.1	0.4	-0.4
Bone: cortical apparent density	0.9	1.3	2.6	-1.2	-1.2	1.6	0.3	0.9
Bone: cortical area	1.9	3.0	5.9	1.9	2.4	-1.6	1.7	0.0
Bone: cortical porosity	1.2	1.3	2.2	1.5	0.8	-1.4	-0.6	-1.1
Bone: cortical porosity	1.1	1.2	1.9	1.1	0.5	-1.3	-0.9	-1.4
Bone: cortical thickness	1.4	2.3	6.2	0.3	2.2	-0.7	2.5	0.5
Bone: cortical thickness	1.7	2.0	6.8	-0.4	1.5	0.1	2.6	0.9
Bone: cortical tissue density	0.9	1.3	2.5	-1.2	-1.2	1.6	0.3	0.9
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	0.1	0.5	-0.8	-0.4	-1.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.2	0.8	0.5	-1.1	-0.7	-1.0
Condit. Reinf. active responses	0.2	0.3	0.7	-0.3	0.4	-0.6	-0.1	-0.9
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.6	0.1	0.0	0.2	-0.3
Incentive salience index mean	0.2	0.3	0.5	0.7	-0.0	-0.5	-0.7	-0.2
Condit. Reinf. lever presses	0.4	0.5	1.5	0.7	-0.8	0.0	-1.2	0.2
Condit. Reinf. active minus inactive responses	1.8	2.4	4.6	1.1	1.4	-2.0	-0.3	-2.1
Condit. Reinf. active-inactive response ratio	1.3	1.6	3.6	0.6	0.9	-1.6	-0.7	-1.9
Condit. Reinf. active responses	1.1	1.5	2.5	1.3	0.9	-1.6	-0.5	-1.6
Condit. Reinf. inactive responses	0.3	0.4	1.5	1.2	0.1	-0.2	0.0	0.5
Condit. Reinf. lever presses	2.5	3.5	6.5	2.1	1.9	-2.5	-0.1	-1.6
Condit. Reinf. lever reinforcers received	1.1	1.5	3.0	1.0	0.8	-1.5	-0.7	-1.7
Conditioned reinforcement - actives	0.4	0.8	3.4	-0.3	0.4	0.0	1.9	0.4
Conditioned reinforcement - inactives	0.9	1.4	1.9	-1.3	-0.8	1.2	1.4	1.1
Conditioned locomotion	0.5	0.6	0.9	-1.0	-0.7	0.9	0.6	0.7
Patch foraging indifference point 0 sec	1.2	2.2	3.9	0.6	2.0	-1.9	0.5	-1.8
Patch foraging indifference point AUC	0.4	0.5	1.1	0.4	1.0	-0.5	1.1	0.3
Delay disc. indifference point, 0s delay	1.3	1.4	3.4	0.4	-0.1	1.0	1.5	1.8
Delay disc. indifference point, 16s delay	1.7	1.9	5.9	-2.4	-1.2	1.3	-0.0	-0.4
Delay disc. indifference point, 2s delay	1.4	1.6	3.3	1.8	1.2	-0.5	1.4	0.9
Delay disc. indifference point, 24s delay	2.3	2.6	5.5	-2.3	-1.9	1.9	-0.2	0.5
Delay disc. indifference point, 4s delay	1.2	1.2	4.2	-0.7	0.4	0.8	2.0	0.9
Delay disc. indifference point, 8s delay	0.4	0.5	1.1	-0.1	-0.1	0.8	1.0	1.0
Indifference point function ln k	0.0	0.1	0.3	0.1	0.4	-0.2	0.5	-0.1
Indifference point function log k	0.0	0.1	0.3	0.1	0.4	-0.2	0.5	-0.1
Patch foraging total patch changes 0 sec	1.6	3.0	5.0	0.7	2.2	-2.2	0.5	-2.1
Patch foraging total patch changes 12 sec	0.6	0.8	1.4	0.9	1.0	-1.2	-0.4	-0.9
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	-0.4	0.7	-0.4	0.6	-0.2
Patch foraging total patch changes 24 sec	1.3	2.2	4.6	0.9	2.1	-1.7	1.0	-1.1
Patch foraging total patch changes 6 sec	1.2	1.8	2.8	-0.8	1.6	-1.0	1.3	-1.7
Patch foraging time to switch 0 sec	1.9	3.8	8.1	-1.3	-2.8	2.0	-2.2	0.8
Patch foraging water rate 0 sec	0.3	0.6	1.0	0.9	0.9	-1.0	0.4	-0.6
Patch foraging water rate 12 sec	1.6	3.4	6.8	1.2	2.6	-2.2	1.6	-1.2
Patch foraging water rate 18 sec	0.8	1.3	2.2	0.6	1.3	-1.4	0.2	-1.5
Patch foraging water rate 24 sec	0.4	0.6	1.9	0.6	0.9	-0.1	1.4	0.3
Patch foraging water rate 6 sec	0.5	0.8	2.6	-0.4	1.1	-0.3	1.6	-0.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	-0.2	0.3	0.1	0.1
Distance traveled before self-admin	0.3	0.5	1.2	-0.2	0.1	0.5	1.1	0.9
Distance traveled after self-admin	1.0	1.2	3.0	0.5	0.5	0.3	1.5	1.7
Extensor digitorum longus weight	1.8	7.1	21.9	4.7	2.1	-1.1	1.8	2.1
Bone: elastic displacement	0.4	0.5	1.7	-1.3	-0.1	0.6	0.7	-0.3
Bone: elastic work	0.4	0.5	1.7	0.2	0.9	-0.3	1.3	0.1
Bone: endosteal estimation	1.0	2.1	7.4	2.7	0.9	-1.5	-0.4	-0.1
Bone: endosteal perimeter	0.4	0.8	3.4	1.8	0.1	-0.5	-0.4	0.5
Epididymis fat weight	1.2	4.2	7.1	2.1	2.7	-2.6	0.7	-1.6
Delta time in closed arm before/after self-admin	0.7	0.6	1.1	0.7	-0.8	0.5	-0.8	1.0
Delta time in open arm before/after self-admin	2.3	2.3	4.4	1.5	2.1	-1.9	0.6	-0.9
Diff in mean of infusions in LGA sessions	0.5	0.6	1.8	-0.5	0.6	-0.5	0.4	-1.3
Delay discount exponential model param	0.6	0.7	1.1	0.9	0.4	-1.1	-1.0	-0.7
Extinction: sum of active levers before priming	0.5	0.5	1.4	-0.4	-0.9	0.4	-1.2	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.6	0.0	0.2	-0.5	-0.4	-0.8
Bone: final force	2.4	3.8	6.6	2.6	2.5	-1.7	1.8	0.1
Bone: final moment	2.3	3.7	6.5	2.4	2.5	-1.8	1.7	-0.2
Food consumed during 24 hour testing period	0.6	0.8	1.8	1.4	0.9	-0.5	0.9	0.5
Glucose	0.0	0.1	0.2	-0.4	-0.1	0.0	-0.1	-0.2
Heart weight	0.1	0.1	0.3	-0.5	0.3	-0.1	0.5	-0.1
Delay discount hyperbolic model param	0.3	0.4	0.9	0.4	0.1	-0.7	-0.9	-0.6
Intermittent access intake day 1-15 change	1.5	3.0	4.5	-1.4	-1.8	2.1	1.0	2.1
Intermittent access intake escalation	1.7	3.5	5.3	-1.7	-1.9	2.3	1.3	2.1
Intermittent access intake escalation 2	4.3	4.9	7.9	-1.8	-2.4	2.8	1.3	2.4
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.2	-0.9	-0.9	1.1	0.5	1.1
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.5	0.7	0.5	-0.5	0.3	0.4
Intermitt. access escalation Index	0.1	0.2	0.4	0.6	0.3	-0.4	-0.2	-0.4
Intermittent access day 1 total infusions	0.7	1.1	1.9	1.0	1.3	-1.4	-0.2	-1.0
Intermittent access day 15 total infusions	0.2	0.3	0.5	-0.4	-0.4	0.6	0.7	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.0	0.0	0.2	0.6	0.2
Intermittent access total infusions	0.6	0.7	1.2	0.7	1.1	-0.8	1.0	-0.2
Intermittent access day 1 locomotion	0.8	1.0	1.8	0.6	1.3	-1.3	0.2	-1.0
Intermittent access day 15 total locomotion	0.2	0.3	0.5	-0.3	0.7	-0.5	0.7	-0.5
Intermittent access total locomotion	0.8	1.0	1.7	0.6	1.3	-1.2	0.4	-1.1
Intermittent access standard deviation	0.8	1.7	3.9	0.2	-0.4	0.9	2.0	2.0
Left kidney weight	1.5	7.0	12.7	3.2	3.6	-2.6	2.2	-0.1
Right kidney weight	2.1	9.6	17.3	3.7	4.2	-3.3	2.2	-0.8
Cocaine induced anxiety	0.1	0.2	0.3	-0.3	-0.5	0.4	-0.3	0.5
Post-drug Anxiety	0.4	0.5	1.3	-1.1	-0.4	0.7	0.5	-0.2
Baseline Anxiety	0.6	0.7	2.8	-0.6	0.5	0.2	1.7	-0.4
Tail length	0.7	2.6	5.5	1.1	2.4	-1.6	1.8	-0.5
Length with tail	0.4	1.6	3.4	0.4	1.8	-1.5	1.0	-1.1
Length without tail	0.1	0.3	1.4	-1.2	-0.0	0.1	0.1	-0.5
Times rat made contact with spout	0.8	0.9	3.0	0.9	-0.1	0.5	0.7	1.7
Lifetime Intake	0.8	1.0	1.7	1.0	1.3	-1.0	1.0	-0.3
Liver weight, left	1.3	2.1	5.2	1.0	-0.1	-1.6	-2.3	-1.5
Liver weight, right	1.0	1.7	4.8	1.2	-0.3	-1.1	-2.2	-0.9
Locomotor activity	0.7	1.0	1.7	1.2	0.7	-1.3	-1.0	-0.9
Locomotor testing distance	0.5	0.9	1.5	1.2	0.9	-1.2	-0.4	-0.8
Locomotor testing rearing	0.7	1.4	2.2	1.0	0.5	-1.3	-1.3	-1.5
Locomotion in novel chamber	1.0	1.3	2.7	0.5	1.1	-1.5	-0.5	-1.6
Locomotion in novel chamber post-restriction	0.7	1.1	3.8	-0.3	0.7	-1.1	-0.4	-1.9
Fecal boli incidents, locomotor time 1	1.0	1.5	4.8	-0.2	-1.4	0.3	-2.2	-0.5
Change in fecal boli incidents, locomotor task	2.2	2.2	4.2	-0.2	2.1	-1.0	2.0	-1.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.4	0.1	0.3	0.6	0.5
Bouts of movement, locomotor time 1	1.7	2.0	3.6	-1.7	-1.9	1.2	-1.5	-0.1
Total resting periods, locomotor time 1	2.0	2.3	4.3	-1.7	-2.1	1.3	-1.6	-0.1
Rest time, locomotor task time 1	1.2	1.5	2.6	-1.1	-1.6	1.5	-0.6	0.9
Distance moved, locomotor task time 1	1.6	2.3	4.2	1.4	2.1	-2.0	0.7	-1.1
Vertical activity count, locomotor time 1	0.7	1.6	4.3	1.0	1.5	-0.4	2.1	0.6
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.7	1.3	0.9	-0.3	1.0	0.8
Bouts of movement, locomotor time 2	1.4	2.2	7.1	1.6	-0.9	-0.6	-2.7	-0.4
Total resting periods, locomotor time 2	1.2	2.0	5.9	1.7	-0.7	-0.7	-2.4	-0.4
Rest time, locomotor task time 2	0.0	0.1	0.2	-0.2	0.1	0.2	0.4	-0.2
Distance moved, locomotor task time 2	0.8	0.9	2.7	0.4	0.1	0.6	1.2	1.6
Vertical activity count, locomotor time 2	1.2	1.6	4.5	-0.2	0.3	1.0	2.1	1.6
Light reinforcement 1	0.3	0.8	1.8	-0.3	-0.7	0.0	-1.2	-1.3
Light reinforcement 2	0.2	0.3	1.5	-0.1	0.2	-0.4	-0.3	-1.2
Bone: marrow area	0.9	1.9	6.8	2.6	0.9	-1.4	-0.4	-0.1
Bone: maximum diameter	1.3	2.4	5.8	2.4	1.7	-1.7	0.4	-0.2
Bone: maximum force	2.0	3.6	5.9	2.4	2.4	-1.6	1.8	0.3
Bone: maximum moment	1.9	3.3	5.9	2.3	2.4	-1.7	1.7	-0.1
Mean time between licks in bursts	0.2	0.5	1.2	-0.2	-1.1	0.4	-1.1	0.0
Mean num. licks in bursts	2.7	4.2	8.2	2.9	2.5	-2.3	0.9	-0.5
Cd content in liver	2.1	2.3	7.4	-0.7	0.4	-1.4	-1.2	-2.7
Co content in liver	1.7	2.0	6.0	-1.5	1.1	0.6	2.5	0.4
Cu content in liver	1.2	1.4	3.0	1.0	1.7	-1.3	1.0	-0.6
Fe content in liver	0.4	0.5	1.3	-1.0	0.4	0.3	1.1	0.1
K content in liver	0.2	0.2	0.4	0.6	0.2	-0.5	-0.3	-0.4
Mg content in liver	0.5	0.5	1.1	1.0	-0.0	-0.6	-0.8	-0.5
Mn content in liver	0.2	0.3	1.1	1.0	0.1	-0.3	-0.3	0.3
Na content in liver	1.5	1.6	6.3	2.5	-0.0	-0.6	-0.8	0.8
Rb content in liver	2.0	2.3	5.9	-1.5	1.3	-1.2	0.5	-2.4
Se content in liver	0.1	0.2	0.6	0.2	-0.1	0.3	0.3	0.8
Sr content in liver	0.7	0.6	1.6	1.3	-0.3	-0.5	-1.1	0.2
Zn content in liver	2.0	2.2	4.6	2.2	1.2	-1.8	-0.5	-1.1
Bone: minimum diameter	0.8	1.5	5.0	2.2	1.1	-1.1	0.2	0.1
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.9	0.3	0.1	0.7	0.0
Time in novel zone, hab. session 1	0.4	0.4	0.9	1.0	-0.1	-0.5	-0.7	-0.3
Total zone transitions, hab. session 1	1.4	2.0	4.6	0.8	2.2	-1.3	1.7	-0.5
Total locomotion distance, hab. session 1	3.7	5.3	11.1	2.0	3.3	-2.3	2.1	-1.2
Locomotion velocity, hab. session 1	3.2	4.5	8.9	1.9	3.0	-2.3	1.6	-1.5
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.4	0.7	-0.5	0.5	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.1	-0.1	-0.1	-0.4	-0.5
Total zone transitions, hab. session 2	1.6	2.1	4.3	1.2	2.1	-1.6	1.0	-1.0
Total locomotion distance, hab. session 2	1.7	2.3	4.9	1.3	2.2	-1.4	1.6	-0.6
Locomotion velocity, hab. session 2	1.9	2.6	5.1	1.7	2.3	-1.5	1.5	-0.6
Novel to familiar place preference ratio	0.5	0.5	1.4	-1.2	-0.0	0.6	0.8	0.3
Novelty place preference	0.8	0.9	2.1	-1.5	-0.2	1.0	1.0	0.6
Time in novel zone, NPP test	0.6	0.7	1.9	-1.4	-0.0	0.7	0.9	0.2
Total zone transitions, NPP test	0.6	0.8	1.7	0.9	1.3	-0.8	1.0	-0.2
Total locomotion distance, NPP test	0.8	1.1	3.2	0.6	1.4	-0.3	1.8	0.1
Locomotion velocity, NPP test	0.7	0.9	2.9	0.5	1.2	-0.2	1.7	0.3
Intraocular pressure	0.2	0.3	0.4	0.7	0.6	-0.6	0.3	-0.2
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.8	0.6	-0.7	-0.2	0.0
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	0.9	0.6	-0.6	0.2	0.5
Parametrial fat weight	3.8	9.0	14.7	2.7	3.8	-3.8	0.8	-2.8
Pavlov. Cond. lever latency	2.1	2.6	7.3	-2.0	1.2	0.5	2.7	0.2
Pavlov. Cond. magazine entry latency	3.6	4.6	11.7	3.4	0.0	-1.9	-2.7	-0.7
Pavlov. Cond. change in total contacts	2.7	2.9	6.5	2.2	-1.6	0.1	-2.5	0.8
Pavlov. Cond. index score	3.1	4.0	9.5	2.8	-0.9	-1.1	-3.1	-0.4
Pavlov. Cond. latency score	2.7	3.5	7.7	2.7	-0.6	-1.2	-2.8	-0.5
Pavlov. Cond. lever contacts	2.8	3.3	7.4	2.7	-0.7	-1.1	-2.7	-0.4
Pavlov. Cond. magazine entry number	2.3	2.9	6.6	-2.6	0.8	0.8	2.5	-0.0
Pavlov. Cond. intertrial magazine entries	1.1	1.3	3.5	-1.9	0.8	-0.0	1.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	10.4	3.1	-0.8	-1.3	-3.2	-0.4
Pavlov. Cond. response bias	2.8	3.5	8.6	2.7	-1.2	-0.6	-2.9	0.2
Pavlov. Cond. lever latency	2.2	3.0	6.4	-1.6	-2.0	2.5	-0.1	1.4
Pavlov. Cond. magazine entry latency	0.7	0.8	2.0	-0.5	-1.4	0.6	-1.1	0.4
Pavlov. Cond. change in total contacts	1.6	2.6	4.8	0.2	1.9	-2.2	0.2	-2.2
Pavlov. Cond. index score	0.5	0.7	1.8	0.6	0.7	-1.3	-0.5	-0.9
Pavlov. Cond. latency score	0.4	0.5	1.2	0.6	0.5	-1.1	-0.5	-0.6
Pavlov. Cond. lever contacts	2.3	3.1	6.8	1.7	2.0	-2.6	-0.1	-1.4
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	1.1	1.1	-0.5	0.9	0.2
Pavlov. Cond. intertrial magazine entries	1.7	2.6	6.7	2.6	1.5	-1.8	-0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	0.5	0.4	-1.1	-0.7	-0.8
Pavlov. Cond. response bias	1.0	1.4	3.1	0.9	1.0	-1.8	-0.5	-1.3
Time in closed arm before self-admin	0.1	0.1	0.3	0.1	0.5	-0.4	0.5	-0.2
Time in closed arm after self-admin	0.4	0.4	0.9	-0.9	-0.3	0.6	0.9	0.3
Time in open arm before self-admin	1.1	1.2	2.4	-1.1	-1.6	1.3	-0.8	0.4
Time in open arm after self-admin	0.8	0.9	2.7	1.6	0.8	-0.7	-0.2	0.7
Bone: periosteal estimation	1.7	3.5	8.9	3.0	2.1	-1.9	0.8	0.1
Bone: periosteal perimeter	1.2	2.1	5.1	2.3	1.4	-1.7	-0.1	-0.6
Bone: post-yield work	3.7	5.5	9.7	3.0	1.9	-3.1	-1.1	-1.9
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	0.8	0.5	-0.7	-0.8	-0.5
Progressive ratio test 1 breakpoint	0.3	0.4	0.8	0.7	0.4	-0.6	-0.9	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.1	0.3	0.1	-0.4	-1.1	-0.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.9	0.3	0.4	-0.6	-0.9	-0.6
Progressive ratio test 2 breakpoint	0.4	0.4	0.9	0.2	0.4	-0.7	-1.0	-0.7
Progressive ratio test 2 inactive lever presses	0.3	0.6	1.0	0.9	0.9	-1.0	-0.3	-0.4
Incentive Sensitization - Responses	0.2	0.2	1.0	0.2	0.1	-0.3	-1.0	-0.2
Incentive Sensitization - Breakpoint	0.2	0.3	0.9	0.3	0.3	-0.5	-0.9	-0.4
Sum of active levers in priming session hrs 5-6	2.5	2.3	7.6	-0.1	-0.7	-0.6	-2.8	-1.7
Progressive ratio	0.2	0.4	1.1	0.0	0.7	-0.5	0.4	-1.0
Food seeking constrained by brief footshock	0.5	0.6	2.0	-1.4	-0.5	0.7	0.2	0.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	0.1	-0.7	0.4	-0.6	0.9
Retroperitoneal fat weight	4.0	17.0	29.8	3.1	4.7	-5.5	-0.3	-4.9
Reaction time number correct	0.3	0.7	1.9	-0.2	-0.6	-0.4	-1.4	-0.9
Reaction time mean minus median	0.1	0.1	0.3	0.3	0.5	-0.3	0.4	0.2
Reaction time mean minus median AUC	0.1	0.3	0.5	-0.0	0.7	-0.7	0.0	-0.7
Reaction time num false alarms	1.3	1.8	3.5	-1.3	-1.1	1.9	0.6	1.6
Reaction time num false alarms AUC	0.7	1.0	2.0	-0.8	-1.1	1.4	0.0	1.1
Reaction time trials correct on left	0.3	0.7	1.9	-0.2	-0.6	-0.4	-1.4	-0.9
Reaction time trials on left	0.4	0.7	2.1	-0.1	-0.6	-0.4	-1.5	-1.0
Reaction time mean	0.3	0.4	0.8	0.8	0.9	-0.8	0.1	-0.3
Reaction time mean AUC	0.1	0.2	0.3	0.6	0.5	-0.5	-0.3	-0.3
Median of all reaction times	0.4	0.5	0.9	0.9	0.9	-0.9	-0.2	-0.4
Reaction time omissions	0.8	1.2	3.6	0.6	-0.1	-0.9	-1.9	-1.1
Reaction time false alarm rate	1.2	1.7	3.2	-0.8	-0.9	1.8	0.9	1.8
Reaction time premature initiation rate	0.5	0.7	1.6	1.1	0.3	0.2	0.6	1.3
Reaction time premature initiations	0.2	0.3	0.6	0.8	-0.3	0.2	-0.3	0.8
Std. dev. reaction times	0.3	0.6	1.2	0.7	1.1	-0.9	0.3	-0.4
Reaction time trials completed	0.4	0.7	2.1	-0.1	-0.6	-0.4	-1.5	-1.0
Reaction time trials AUC	0.3	0.6	1.6	-0.0	-0.4	-0.5	-1.3	-0.9
Run reversals in cocaine runway, females	2.5	2.5	4.1	1.9	1.2	-0.3	2.0	1.8
Run reversals in cocaine runway, males	0.7	0.7	1.2	-1.1	-0.8	1.1	0.2	0.7
Latency to leave start box in cocaine runway	0.8	0.9	2.1	-0.4	1.1	-0.9	0.4	-1.5
Latency to leave start box in cocaine runway, F	0.4	0.5	1.2	-0.1	0.2	-0.7	-0.9	-1.1
Latency to leave start box in cocaine runway, M	1.0	0.9	1.5	-0.7	1.2	-0.6	1.2	-1.0
Std. dev. time between licks in bursts	0.5	0.6	1.6	0.9	-0.5	-0.5	-1.3	-0.5
Total sessions with >9 infusions	3.3	4.0	6.5	2.6	2.5	-2.4	0.7	-0.9
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.6	0.6	-0.5	0.3	0.0
Short access day 10 total inactive lever presses	0.7	1.6	2.4	-1.4	-1.6	1.5	-0.3	1.1
Short access day 1 total infusions	1.0	1.3	2.2	1.4	1.5	-1.3	0.9	-0.1
Short access day 10 total infusions	1.1	1.4	2.7	1.7	1.4	-1.5	0.1	-0.4
Short access total infusions	1.8	2.3	3.9	1.8	2.0	-1.8	0.9	-0.6
Short access day 1 locomotion	0.5	0.7	2.1	0.6	0.7	-0.3	1.5	0.6
Short access day 10 total locomotion	0.6	1.0	3.0	1.7	1.0	-1.0	-0.2	0.1
Short access total locomotion	2.3	2.7	4.7	1.7	2.2	-1.9	1.2	-1.1
One hour access (0.3 mA shock)	0.4	0.4	0.8	0.4	0.3	-0.5	-0.9	-0.9
Compulsive drug intake	0.8	1.0	2.2	0.5	0.3	-0.7	-1.5	-1.3
One hour access (shock baseline)	0.1	0.2	0.3	-0.5	-0.2	0.4	0.5	0.2
Social response proportion	1.0	1.1	2.4	0.5	0.7	-1.4	-0.7	-1.5
Social responses	0.8	1.0	2.6	-0.0	-0.5	-0.6	-1.6	-1.3
Social time	0.2	0.2	0.8	-0.5	-0.2	-0.1	-0.3	-0.9
Soleus weight	2.0	6.0	11.8	2.0	3.4	-1.6	3.4	0.2
Bone: stiffness	1.5	2.5	4.4	1.7	2.1	-1.0	1.9	0.8
Tibialis anterior weight	3.3	11.2	19.2	4.4	4.3	-2.8	3.1	0.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.5	0.4	0.2	0.0	0.7	0.2
Time to tail flick, vehicle, after self-admin	1.3	1.8	3.9	-1.4	-1.4	0.5	-2.0	-0.9
Time to tail flick, test, before self-admin	0.1	0.2	0.7	0.2	-0.1	0.1	0.0	0.8
Time to tail flick, test, after self-admin	1.6	1.7	2.6	0.1	-1.6	1.1	-1.4	1.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.6	-0.3	-0.0	-0.5	-1.3	-1.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	0.7	-0.3	-0.0	-0.6	0.3
Tibia length	0.2	0.6	1.2	0.2	1.1	-0.7	1.0	-0.3
Ambulatory time before self-admin	0.8	1.2	3.1	-0.9	0.0	1.0	1.8	1.0
Ambulatory time after self-admin	1.4	1.6	4.0	0.3	0.5	0.5	2.0	1.9
Bone: tissue strength	0.3	0.3	0.8	-0.2	0.1	0.4	0.9	0.8
Total heroin consumption	1.1	1.3	3.1	0.0	-0.3	-0.7	-1.8	-1.7
Bone: trabecular number	0.5	0.8	1.9	0.7	1.2	-0.6	1.4	0.0
Bone: trabecular spacing	0.8	1.1	3.5	0.1	-1.3	-0.1	-1.9	-0.5
Bone: trabecular thickness	3.4	4.2	10.0	0.8	3.2	-1.9	2.2	-1.5
Bone: trabecular tissue density	0.2	0.3	0.7	-0.8	0.4	0.3	0.8	0.3
Water consumed over 24 hours	2.2	2.9	6.3	-0.6	-1.8	2.1	0.2	2.5
Number of responses in last shaping day	0.2	0.2	0.6	0.8	0.4	-0.4	0.0	0.2