Hub : Genes

Smdt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Smdt1 0.06 0.06 8.5e-03 0 0 -0 0 1.4e-01 1.5e-01 4.3e-01 2.0e-01
2 NAcc intron excision ratio chr7_113862383_113864022 0.05 0.03 1.6e-03 0.02 0.03 0.04 0.03 2.9e-03 1.3e-04 5.4e-05 6.7e-05
3 NAcc intron excision ratio chr7_113862334_113864022 0.05 0.03 1.5e-03 0.01 0.03 0.03 0.03 1.7e-02 1.5e-04 1.3e-04 3.1e-04
4 RMTg gene expression Smdt1 0.12 0.08 4.7e-03 0.04 0.06 0.03 0.04 2.3e-02 1.0e-02 5.7e-02 2.3e-02
5 RMTg intron excision ratio chr7_113862334_113864022 0.1 0.07 8.4e-03 0.06 0.06 0.07 0.04 9.8e-03 1.3e-02 5.8e-03 2.5e-02
6 PL gene expression Smdt1 0.09 0.05 4.4e-05 0.04 0.04 0.05 0.04 1.8e-05 4.0e-05 2.8e-06 1.1e-05
7 pVTA gene expression Smdt1 0.13 0.09 2.8e-04 0.03 0.06 0.07 0.04 2.6e-02 9.9e-04 8.2e-04 5.0e-03
8 Liver gene expression Smdt1 0.22 0.12 1.8e-04 0.03 0.03 0.01 0.01 7.8e-04 7.8e-04 3.3e-02 1.2e-02
9 Liver intron excision ratio chr7_113862383_113864022 0.12 0.06 4.4e-10 0.08 0.08 0.09 0.09 2.3e-09 5.0e-09 8.3e-10 1.2e-09
10 Liver intron excision ratio chr7_113862334_113864022 0.19 0.1 4.1e-14 0.12 0.12 0.12 0.12 2.9e-13 1.1e-12 2.2e-13 1.4e-13
11 NAcc gene expression Smdt1 0.05 0.03 8.7e-06 0.05 0.04 0.04 0.04 3.6e-06 4.4e-05 1.3e-05 1.7e-05
12 Brain gene expression Smdt1 0.15 0.08 6.6e-07 0.07 0.06 0.03 0.05 1.8e-07 2.7e-06 2.2e-03 2.5e-05
13 Adipose gene expression Smdt1 0.04 0.03 1.8e-03 0.03 0.02 0.02 0.02 8.5e-04 3.6e-03 5.5e-03 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.7-0.8-0.60.7-0.5-0.4-0.80.3-0.4-0.3-0.3-0.2-0.1-0.1
Area under the delay curve0.20.21.4-1.2-0.10.2-0.4-0.10.20.10.8-0.4-0.10.10.30.3
BMI with tail0.72.35.82.1-0.90.72.42.00.1-2.3-0.2-1.2-1.2-1.3-1.5-1.5
BMI without tail0.10.21.60.6-0.50.10.2-0.21.30.1-0.20.30.3-0.00.20.2
Body weight0.52.06.52.61.4-1.22.22.1-0.3-1.80.2-0.4-0.6-0.8-1.0-0.9
Weight adjusted by age0.81.04.1-0.02.0-1.9-0.6-0.50.60.80.50.70.70.90.70.7
Bone surface0.20.41.30.01.1-1.0-0.6-0.8-0.10.8-0.80.40.1-0.10.1-0.0
Bone volume0.00.10.3-0.00.5-0.4-0.3-0.4-0.10.4-0.20.20.00.00.10.0
Breakpoint value in progressive ratio session0.40.41.10.3-0.80.90.40.3-0.9-0.3-1.0-0.5-0.6-0.7-0.7-0.7
Number of licking bursts0.10.20.5-0.40.1-0.1-0.6-0.70.40.6-0.2-0.3-0.10.40.40.2
Context. condit. distance diff. score1.61.97.12.71.7-1.61.92.2-0.4-1.51.20.40.4-0.2-0.1-0.0
Locomotion velocity, session 10.80.93.50.71.9-1.8-0.3-0.70.70.9-0.41.00.70.30.30.3
Locomotion distance, session 11.31.63.7-1.20.3-0.4-1.8-1.91.31.90.01.11.11.21.31.3
Locomotion velocity, session 20.20.31.30.70.9-0.80.3-0.11.10.1-0.00.50.3-0.10.10.1
Locomotion distance, session 20.81.23.1-1.7-1.81.7-0.9-1.2-0.30.6-1.3-0.8-0.8-0.6-0.4-0.4
Locomotion velocity, session 30.91.02.40.31.5-1.5-0.4-0.41.10.70.91.51.30.80.80.8
Locomotion distance, session 31.92.13.0-1.30.4-0.6-1.7-1.41.71.71.31.41.51.71.71.7
Stereotopy head waving bouts, day 30.40.51.20.91.1-0.80.80.7-0.7-0.5-0.50.1-0.3-0.7-0.7-0.8
Stereotopy head waving duration, day 31.31.65.12.22.3-1.91.51.3-0.5-0.9-0.30.5-0.0-0.7-0.7-0.7
Locomotion velocity, session 70.60.62.8-0.30.3-0.4-0.3-0.11.70.31.40.70.70.70.80.8
Locomotion distance, session 70.40.52.2-1.5-1.21.2-0.10.10.5-0.31.1-0.5-0.3-0.00.10.1
Stereotopy head waving bouts, day 71.92.18.42.42.9-2.90.60.50.10.20.11.61.10.20.40.4
Stereotopy head waving duration, day 71.61.97.02.02.6-2.70.40.30.60.30.51.71.40.50.80.7
Locomotion velocity, session 81.51.87.72.80.8-0.71.81.5-1.4-1.4-1.1-0.7-0.9-1.0-1.1-1.1
Locomotion distance, session 80.20.31.21.10.6-0.70.70.8-0.2-0.60.60.40.3-0.10.10.2
Degree of sensitization distance2.62.65.11.0-0.91.12.12.0-1.4-2.3-0.4-1.7-1.7-1.8-1.7-1.7
Degree of sensitization stereotypy1.71.96.82.02.6-2.60.20.30.40.50.51.61.40.60.80.8
Conditioned locomotion0.80.92.90.40.9-0.9-0.00.30.40.11.71.31.31.01.11.1
Cocaine response after cond. corrected0.20.20.80.10.3-0.4-0.2-0.30.90.40.50.50.60.40.50.4
Cocaine response after cond. not corrected0.30.41.10.10.4-0.6-0.3-0.51.10.50.50.80.80.50.60.6
Cocaine response before conditioning0.10.10.2-0.30.2-0.2-0.3-0.40.40.20.10.40.30.10.20.3
Saline control response1.01.34.00.62.0-1.9-0.5-0.60.40.70.51.51.30.91.11.0
Bone: connectivity density0.10.21.0-0.4-0.30.4-0.2-0.1-1.00.1-0.6-0.3-0.4-0.4-0.2-0.3
Bone: cortical apparent density0.20.21.2-1.1-0.40.6-0.6-0.6-0.40.5-0.1-0.0-0.10.00.0-0.0
Bone: cortical area0.60.93.01.70.7-0.61.41.2-0.2-1.0-0.3-0.3-0.6-0.8-0.9-0.9
Bone: cortical porosity0.10.20.40.70.6-0.60.40.3-0.2-0.30.30.60.30.00.0-0.0
Bone: cortical porosity0.30.31.51.20.8-0.80.80.7-0.3-0.50.10.40.1-0.3-0.3-0.3
Bone: cortical thickness1.11.92.60.6-1.51.51.31.2-1.0-1.4-1.0-1.6-1.6-1.5-1.5-1.6
Bone: cortical thickness1.21.42.60.8-1.21.31.31.3-0.8-1.4-0.7-1.6-1.4-1.2-1.1-1.2
Bone: cortical tissue density0.20.21.2-1.1-0.50.6-0.6-0.5-0.40.4-0.1-0.1-0.1-0.00.0-0.1
Condit. Reinf. active minus inactive responses0.30.30.8-0.9-0.60.70.1-0.1-0.2-0.2-0.4-0.5-0.5-0.8-0.7-0.7
Condit. Reinf. active-inactive response ratio0.10.10.30.30.5-0.40.50.30.0-0.3-0.20.1-0.1-0.5-0.4-0.4
Condit. Reinf. active responses0.50.63.4-1.9-1.01.0-0.7-0.80.30.3-0.2-0.4-0.3-0.3-0.2-0.2
Condit. Reinf. inactive responses0.81.05.1-2.3-1.11.0-1.3-1.30.60.80.1-0.20.00.40.50.4
Incentive salience index mean0.40.51.9-1.4-1.01.1-0.1-0.2-0.1-0.2-0.3-0.7-0.7-0.7-0.6-0.6
Condit. Reinf. lever presses0.30.42.8-1.7-0.70.8-0.6-0.60.70.20.3-0.2-0.2-0.10.10.1
Condit. Reinf. active minus inactive responses1.31.63.00.4-1.01.20.90.8-1.7-0.9-1.7-1.3-1.4-1.6-1.4-1.5
Condit. Reinf. active-inactive response ratio2.42.54.40.5-1.11.41.21.1-2.1-1.1-2.0-1.7-1.8-2.0-1.9-2.0
Condit. Reinf. active responses0.71.01.51.20.20.01.11.0-1.2-1.0-1.1-0.7-1.0-1.2-1.1-1.1
Condit. Reinf. inactive responses0.40.52.11.01.5-1.30.60.70.5-0.50.60.40.30.00.10.2
Condit. Reinf. lever presses0.60.92.8-0.2-0.50.70.2-0.1-1.6-0.3-1.7-0.8-1.0-1.2-1.0-0.9
Condit. Reinf. lever reinforcers received0.71.02.50.7-0.00.31.00.9-1.6-0.9-1.3-0.8-1.1-1.4-1.2-1.1
Conditioned reinforcement - actives0.20.20.90.20.9-0.80.30.40.6-0.20.8-0.30.10.10.30.3
Conditioned reinforcement - inactives0.60.72.0-0.2-0.40.70.60.6-0.9-0.8-0.8-1.4-1.1-0.9-1.0-0.9
Conditioned locomotion0.80.92.81.00.10.01.51.7-0.2-1.40.3-0.8-0.8-1.0-0.9-0.8
Patch foraging indifference point 0 sec0.50.82.9-0.1-0.60.80.1-0.3-1.3-0.2-1.7-0.8-1.0-1.0-1.0-0.9
Patch foraging indifference point AUC0.10.10.3-0.3-0.10.0-0.2-0.50.30.3-0.4-0.3-0.3-0.2-0.2-0.2
Delay disc. indifference point, 0s delay0.30.41.20.6-0.10.20.91.1-0.6-1.00.6-0.3-0.3-0.3-0.3-0.3
Delay disc. indifference point, 16s delay0.50.52.6-1.6-0.40.4-1.1-1.00.30.80.10.30.30.40.40.5
Delay disc. indifference point, 2s delay0.30.32.0-0.8-0.10.20.10.50.4-0.51.4-0.4-0.10.10.30.3
Delay disc. indifference point, 24s delay0.50.40.7-0.60.8-0.8-0.7-0.50.70.80.70.40.60.50.50.7
Delay disc. indifference point, 4s delay0.91.02.4-0.3-0.40.70.70.6-1.0-0.9-0.8-1.6-1.4-1.3-1.1-1.2
Delay disc. indifference point, 8s delay0.50.52.5-1.6-0.60.6-0.9-0.50.40.51.00.00.30.40.70.7
Indifference point function ln k0.30.51.61.10.4-0.30.91.3-1.1-0.80.10.0-0.1-0.3-0.4-0.4
Indifference point function log k0.30.51.61.10.4-0.30.91.3-1.1-0.80.10.0-0.1-0.3-0.4-0.4
Patch foraging total patch changes 0 sec0.40.72.8-0.2-0.60.7-0.1-0.4-1.2-0.1-1.7-0.7-1.0-0.9-0.8-0.8
Patch foraging total patch changes 12 sec0.40.61.60.2-0.10.20.5-0.1-0.3-0.5-1.3-0.8-1.0-1.1-1.0-1.0
Patch foraging total patch changes 18 sec0.81.02.40.2-0.80.90.50.2-1.2-0.6-1.5-1.1-1.3-1.3-1.1-1.1
Patch foraging total patch changes 24 sec0.10.10.5-0.3-0.10.1-0.3-0.70.40.3-0.50.1-0.1-0.1-0.2-0.1
Patch foraging total patch changes 6 sec0.71.04.40.4-0.20.20.4-0.60.1-0.3-2.1-1.3-1.4-1.3-1.2-1.2
Patch foraging time to switch 0 sec0.30.51.2-0.70.5-0.4-0.5-0.40.90.40.91.10.70.60.60.6
Patch foraging water rate 0 sec0.91.45.31.1-1.21.00.50.0-1.3-0.3-2.3-1.4-1.3-1.3-1.2-1.1
Patch foraging water rate 12 sec0.10.20.9-0.1-0.40.2-0.4-0.6-0.10.7-0.90.30.0-0.10.10.0
Patch foraging water rate 18 sec0.40.63.4-0.3-0.40.4-0.8-1.1-0.81.1-1.8-0.0-0.2-0.2-0.3-0.2
Patch foraging water rate 24 sec1.01.45.91.3-0.70.60.90.1-0.6-0.4-2.4-1.0-1.2-1.3-1.4-1.4
Patch foraging water rate 6 sec0.60.92.0-0.81.1-1.1-1.2-1.40.51.4-0.40.80.80.60.60.6
Seeking ratio, delayed vs. immediate footshock1.21.44.8-2.2-2.11.8-1.3-1.60.31.0-0.50.10.00.00.20.3
Distance traveled before self-admin0.80.92.4-0.6-1.41.60.70.7-0.4-1.2-0.1-1.3-1.1-0.8-0.7-0.7
Distance traveled after self-admin0.91.02.30.3-0.10.30.90.5-1.0-1.0-1.3-1.0-1.1-1.4-1.4-1.5
Extensor digitorum longus weight0.10.31.10.00.1-0.3-0.6-1.10.50.6-0.60.60.60.40.20.3
Bone: elastic displacement0.70.83.01.11.7-1.7-0.2-0.50.90.7-0.50.80.60.40.40.4
Bone: elastic work1.11.55.72.41.2-1.01.61.3-0.4-1.1-1.1-0.5-0.7-1.1-1.1-1.1
Bone: endosteal estimation1.02.19.21.73.0-3.00.1-0.10.80.50.31.71.20.60.50.6
Bone: endosteal perimeter1.53.211.11.83.3-3.30.30.31.40.41.62.11.71.11.01.1
Epididymis fat weight1.02.35.51.82.0-2.11.41.52.2-1.22.31.00.90.60.60.6
Delta time in closed arm before/after self-admin0.60.62.20.5-0.00.21.21.4-0.2-1.50.8-0.7-0.5-0.5-0.5-0.5
Delta time in open arm before/after self-admin0.50.51.1-0.10.6-0.6-0.8-0.50.21.10.30.80.80.90.60.7
Diff in mean of infusions in LGA sessions0.20.31.2-0.9-0.30.5-0.3-0.2-0.60.1-0.1-1.1-0.60.1-0.3-0.3
Delay discount exponential model param0.20.21.41.2-0.0-0.10.40.2-0.3-0.2-0.80.40.0-0.1-0.3-0.4
Extinction: sum of active levers before priming0.10.10.20.1-0.10.20.20.3-0.4-0.2-0.2-0.5-0.3-0.2-0.2-0.3
Active lever presses in extinction session 60.30.20.40.50.10.10.60.5-0.6-0.6-0.5-0.7-0.5-0.5-0.4-0.5
Bone: final force1.82.94.31.4-0.60.82.02.0-2.1-1.9-1.2-1.7-1.9-2.1-1.9-1.9
Bone: final moment2.03.34.91.7-0.40.62.12.0-2.1-2.0-1.5-1.7-2.0-2.2-2.1-2.1
Food consumed during 24 hour testing period1.01.32.61.60.2-0.01.61.4-0.7-1.4-0.6-1.2-1.1-1.1-1.1-1.2
Glucose0.10.21.1-1.1-0.30.4-0.4-0.70.30.1-0.2-0.1-0.1-0.2-0.1-0.1
Heart weight2.43.46.12.5-0.10.32.52.3-1.4-2.4-1.3-1.7-1.8-1.8-2.0-2.0
Delay discount hyperbolic model param0.20.21.01.0-0.0-0.10.2-0.0-0.20.1-0.80.50.20.0-0.2-0.2
Intermittent access intake day 1-15 change0.10.10.4-0.5-0.20.1-0.3-0.60.60.2-0.30.20.10.00.20.1
Intermittent access intake escalation0.10.10.4-0.5-0.10.1-0.4-0.60.50.2-0.40.30.2-0.00.10.1
Intermittent access intake escalation 20.10.10.2-0.10.4-0.4-0.3-0.40.30.3-0.10.30.30.20.30.3
Intermitt. access day 1 inactive lever presses2.52.74.20.9-1.21.41.41.4-2.0-1.5-1.8-1.9-1.9-1.6-2.0-1.8
Intermitt. access day 15 inactive lever presses4.34.76.91.0-2.32.42.01.9-2.4-2.2-1.9-2.6-2.4-2.2-2.3-2.3
Intermitt. access escalation Index0.40.40.7-0.3-0.80.80.30.3-0.8-0.5-0.6-0.7-0.7-0.6-0.6-0.6
Intermittent access day 1 total infusions0.70.91.80.90.00.21.21.4-0.7-1.1-0.1-1.1-1.0-1.0-1.0-0.9
Intermittent access day 15 total infusions0.30.40.80.1-0.40.50.50.3-0.2-0.6-0.7-0.8-0.8-0.9-0.7-0.7
Intermittent access terminal intake (last 3 days)0.00.00.10.00.3-0.20.20.30.2-0.20.3-0.2-0.1-0.2-0.00.0
Intermittent access total infusions0.30.30.60.2-0.20.30.70.8-0.4-0.70.0-0.8-0.6-0.7-0.6-0.5
Intermittent access day 1 locomotion0.50.51.30.1-0.20.40.81.1-0.8-0.90.0-0.9-0.7-0.7-0.7-0.6
Intermittent access day 15 total locomotion0.20.21.00.10.20.10.40.8-1.0-0.4-0.1-0.3-0.3-0.5-0.4-0.3
Intermittent access total locomotion0.60.61.30.2-0.20.40.91.1-0.9-0.9-0.1-1.0-0.9-0.9-0.9-0.9
Intermittent access standard deviation0.70.71.50.9-0.70.71.21.0-0.3-1.2-0.4-0.4-0.7-1.1-0.9-0.9
Left kidney weight4.913.847.76.92.3-1.95.65.3-2.2-4.6-1.0-1.5-2.1-3.0-3.3-3.2
Right kidney weight5.415.146.86.82.3-1.86.05.6-1.9-5.0-0.9-1.8-2.5-3.2-3.5-3.5
Cocaine induced anxiety1.51.82.61.1-1.11.11.61.0-0.6-1.3-1.3-1.5-1.6-1.5-1.5-1.6
Post-drug Anxiety0.91.02.21.0-0.70.61.00.5-0.9-0.7-1.5-1.1-1.1-1.0-1.2-1.3
Baseline Anxiety1.01.12.2-1.00.5-0.5-1.5-1.20.41.30.70.81.01.41.21.2
Tail length0.30.81.3-0.11.0-1.0-0.9-0.90.71.1-0.00.90.80.81.01.0
Length with tail0.20.95.21.32.3-1.90.50.7-0.7-0.2-0.10.30.1-0.0-0.1-0.1
Length without tail0.71.42.51.21.3-0.81.51.6-1.6-1.3-0.3-0.7-0.9-1.0-1.3-1.4
Times rat made contact with spout0.60.71.61.10.2-0.01.11.0-0.3-1.1-0.4-1.3-0.9-0.7-0.6-0.7
Lifetime Intake1.21.42.30.7-0.80.91.41.5-1.1-1.5-0.4-1.4-1.3-1.3-1.3-1.2
Liver weight, left1.01.67.00.32.6-2.4-0.10.20.90.21.61.31.10.80.80.8
Liver weight, right2.03.39.10.93.0-2.90.30.61.8-0.12.72.01.81.61.41.4
Locomotor activity0.60.95.32.31.1-1.21.31.0-0.2-0.7-0.40.0-0.1-0.4-0.5-0.5
Locomotor testing distance0.00.00.1-0.10.1-0.2-0.2-0.2-0.10.3-0.00.10.20.10.10.1
Locomotor testing rearing0.50.71.61.21.3-1.20.91.00.8-0.71.20.20.50.10.40.4
Locomotion in novel chamber3.34.07.9-0.31.8-2.1-1.6-1.32.31.91.52.82.52.32.22.2
Locomotion in novel chamber post-restriction1.11.32.2-1.5-0.10.0-1.3-1.11.01.11.11.41.31.31.21.2
Fecal boli incidents, locomotor time 10.10.20.4-0.6-0.70.5-0.4-0.5-0.10.4-0.2-0.3-0.10.00.30.2
Change in fecal boli incidents, locomotor task0.40.41.70.81.3-1.30.00.10.60.30.50.60.60.30.20.3
Time >=10cm from walls, locomotor time 10.00.00.1-0.2-0.20.20.10.2-0.4-0.10.10.1-0.1-0.3-0.2-0.2
Bouts of movement, locomotor time 10.10.20.7-0.4-0.60.50.10.30.5-0.10.8-0.2-0.00.20.10.2
Total resting periods, locomotor time 10.30.31.2-0.7-1.11.10.20.40.1-0.30.7-0.5-0.30.1-0.1-0.0
Rest time, locomotor task time 10.90.93.2-0.4-1.81.70.81.0-0.3-1.20.6-0.9-0.8-0.4-0.6-0.6
Distance moved, locomotor task time 10.50.63.60.61.9-1.60.20.5-0.1-0.20.40.40.3-0.10.20.2
Vertical activity count, locomotor time 10.30.31.20.31.1-0.80.10.0-0.6-0.1-0.7-0.2-0.3-0.6-0.3-0.3
Time >=10cm from walls, locomotor time 20.30.30.5-0.70.2-0.2-0.6-0.40.10.50.70.70.50.60.50.6
Bouts of movement, locomotor time 20.80.81.9-0.0-1.11.20.81.0-0.5-1.10.2-1.4-1.1-0.5-0.8-0.8
Total resting periods, locomotor time 20.91.02.6-0.0-1.31.30.91.0-0.6-1.2-0.1-1.6-1.2-0.7-1.0-0.9
Rest time, locomotor task time 20.20.20.7-0.4-0.80.7-0.0-0.20.3-0.0-0.2-0.7-0.4-0.2-0.1-0.1
Distance moved, locomotor task time 20.50.62.00.71.4-1.10.50.80.2-0.41.00.70.50.20.40.4
Vertical activity count, locomotor time 20.20.20.80.90.9-0.70.40.5-0.3-0.30.10.50.2-0.2-0.1-0.0
Light reinforcement 10.30.63.00.40.5-0.7-0.3-0.2-0.30.60.51.71.20.60.60.6
Light reinforcement 20.30.32.00.1-0.1-0.10.40.5-0.0-0.31.41.00.80.30.20.3
Bone: marrow area1.02.19.71.83.1-3.00.2-0.10.70.40.21.61.10.50.40.5
Bone: maximum diameter1.42.79.93.22.3-2.12.22.0-0.4-1.5-0.20.1-0.4-1.0-1.1-1.1
Bone: maximum force1.93.36.22.3-0.30.42.52.3-1.6-2.2-1.1-1.5-1.7-2.1-2.0-2.0
Bone: maximum moment2.23.86.92.6-0.20.32.62.4-1.6-2.3-1.3-1.6-1.8-2.2-2.1-2.2
Mean time between licks in bursts0.20.30.8-0.9-0.20.1-0.8-0.60.20.60.50.30.50.70.70.7
Mean num. licks in bursts0.60.72.11.40.6-0.51.31.4-0.3-1.20.2-0.3-0.3-0.7-0.6-0.5
Cd content in liver0.90.93.11.81.4-1.50.60.41.4-0.30.50.60.80.60.60.6
Co content in liver0.60.71.61.3-1.10.90.90.9-1.2-0.8-0.4-0.8-0.6-0.5-0.5-0.5
Cu content in liver1.01.26.0-2.4-0.30.5-1.9-1.7-0.31.4-0.20.20.20.50.50.5
Fe content in liver0.30.42.00.71.4-1.1-0.0-0.1-0.50.3-0.60.50.2-0.1-0.1-0.1
K content in liver0.80.72.2-0.4-0.70.90.0-0.2-1.0-0.1-1.5-0.9-1.1-1.1-1.0-1.0
Mg content in liver1.21.22.9-0.9-0.81.10.1-0.2-1.4-0.3-1.7-1.1-1.3-1.4-1.3-1.3
Mn content in liver0.50.61.30.10.8-0.9-0.1-0.11.00.11.11.00.90.80.80.8
Na content in liver0.80.93.0-1.7-1.21.1-1.4-1.3-0.21.0-0.3-0.10.10.40.40.4
Rb content in liver0.30.40.90.50.3-0.00.40.2-0.7-0.4-0.9-0.4-0.6-0.9-0.8-0.8
Se content in liver0.60.71.4-1.20.4-0.4-1.1-1.20.71.10.30.70.70.80.80.8
Sr content in liver0.80.71.3-0.8-0.80.6-0.9-0.81.10.70.80.30.61.01.01.0
Zn content in liver0.50.61.5-0.70.3-0.3-1.2-1.2-0.11.2-0.10.80.80.70.70.7
Bone: minimum diameter0.40.72.51.11.5-1.60.30.20.90.10.51.00.60.20.20.2
Time in familiar zone, hab. session 10.30.31.40.10.6-0.5-0.1-0.11.20.20.70.40.50.70.50.5
Time in novel zone, hab. session 10.30.32.21.50.1-0.40.60.4-0.6-0.3-0.50.10.1-0.3-0.2-0.1
Total zone transitions, hab. session 11.62.35.2-1.90.1-0.3-2.3-2.31.12.20.31.11.21.51.51.5
Total locomotion distance, hab. session 12.53.55.7-1.01.4-1.6-2.1-2.32.12.40.72.12.01.92.02.0
Locomotion velocity, hab. session 11.92.65.0-1.41.0-1.1-2.1-2.21.82.20.41.71.61.51.61.6
Time in familiar zone, hab. session 22.62.75.7-0.21.8-1.7-1.0-0.72.41.12.11.71.71.91.91.8
Time in novel zone, hab. session 22.32.35.51.0-1.21.01.10.7-2.2-1.0-2.3-1.5-1.5-1.8-1.7-1.7
Total zone transitions, hab. session 20.20.20.8-0.6-0.30.3-0.4-0.6-0.70.3-0.9-0.3-0.4-0.3-0.2-0.2
Total locomotion distance, hab. session 20.20.20.6-0.6-0.80.6-0.6-0.80.20.5-0.60.00.00.00.10.1
Locomotion velocity, hab. session 20.30.41.4-1.1-0.80.6-0.9-1.20.50.8-0.50.10.20.20.30.3
Novel to familiar place preference ratio1.11.25.72.41.7-1.71.01.0-0.9-0.6-0.60.0-0.0-0.4-0.4-0.4
Novelty place preference1.41.47.12.71.9-2.01.11.1-0.6-0.6-0.30.20.2-0.3-0.2-0.2
Time in novel zone, NPP test1.71.89.03.02.0-2.11.41.4-0.8-0.8-0.40.10.0-0.4-0.4-0.4
Total zone transitions, NPP test0.91.33.5-1.20.1-0.3-1.8-1.90.71.7-0.40.90.91.01.01.0
Total locomotion distance, NPP test0.30.51.6-0.8-0.50.3-1.1-1.30.41.1-0.70.30.40.40.40.4
Locomotion velocity, NPP test0.91.33.2-1.5-0.40.2-1.6-1.81.11.60.00.80.90.91.01.0
Intraocular pressure0.10.10.50.50.2-0.20.20.60.1-0.00.70.20.30.20.40.4
Delta distance traveled before/after self-admin0.80.93.91.52.0-1.80.30.1-0.30.2-0.80.50.2-0.3-0.5-0.5
Delta ambulatory time before/after self-admin1.21.35.01.82.2-2.00.50.2-0.70.1-1.4-0.0-0.2-0.7-0.8-0.8
Parametrial fat weight0.20.41.1-0.2-1.11.00.50.7-0.6-0.90.3-0.6-0.5-0.4-0.3-0.3
Pavlov. Cond. lever latency0.30.43.11.70.5-0.70.70.9-0.6-0.4-0.00.30.3-0.10.0-0.0
Pavlov. Cond. magazine entry latency0.60.72.5-1.6-1.61.6-0.4-0.50.5-0.10.0-0.9-0.7-0.2-0.3-0.2
Pavlov. Cond. change in total contacts0.91.02.9-1.4-1.61.7-0.1-0.30.1-0.3-0.7-1.4-1.2-0.7-0.7-0.7
Pavlov. Cond. index score0.60.82.4-1.3-1.41.60.1-0.10.1-0.5-0.2-1.2-1.1-0.5-0.7-0.6
Pavlov. Cond. latency score0.50.61.9-1.1-1.21.40.1-0.10.1-0.5-0.3-1.1-1.0-0.4-0.7-0.6
Pavlov. Cond. lever contacts0.60.73.6-1.9-1.21.3-0.7-0.80.60.10.1-0.6-0.50.1-0.1-0.0
Pavlov. Cond. magazine entry number0.40.51.91.41.2-1.30.30.3-0.70.2-0.20.80.60.10.20.1
Pavlov. Cond. intertrial magazine entries0.50.51.9-0.7-0.80.7-0.4-0.6-1.00.4-1.4-0.6-0.6-0.5-0.6-0.7
Pavlov. Cond. lever-magazine prob. diff.0.60.72.5-1.6-1.51.6-0.2-0.20.4-0.30.1-1.0-0.8-0.3-0.4-0.4
Pavlov. Cond. response bias0.70.93.7-1.9-1.61.7-0.4-0.30.4-0.20.3-0.9-0.8-0.2-0.3-0.2
Pavlov. Cond. lever latency0.91.25.60.50.3-0.50.20.61.7-0.12.40.91.21.41.11.0
Pavlov. Cond. magazine entry latency3.23.78.4-1.9-2.42.5-0.5-0.7-2.60.1-2.9-2.1-2.1-1.8-1.5-1.6
Pavlov. Cond. change in total contacts4.76.416.3-0.4-1.72.11.00.7-4.0-1.3-3.7-2.8-3.1-3.1-2.9-2.8
Pavlov. Cond. index score2.53.28.9-1.3-1.82.0-0.2-0.6-2.7-0.1-3.0-1.9-2.0-2.0-1.6-1.6
Pavlov. Cond. latency score3.03.79.7-1.5-2.02.2-0.3-0.6-2.8-0.1-3.1-2.0-2.1-2.1-1.7-1.7
Pavlov. Cond. lever contacts1.31.86.3-0.6-0.60.90.0-0.4-2.2-0.2-2.5-1.2-1.5-1.7-1.4-1.3
Pavlov. Cond. magazine entry number3.03.78.31.42.2-2.30.10.22.90.22.72.12.21.91.81.8
Pavlov. Cond. intertrial magazine entries1.11.44.22.0-0.50.42.02.10.2-2.00.5-0.7-0.5-0.8-0.7-0.6
Pavlov. Cond. lever-magazine prob. diff.2.32.97.9-1.5-1.71.9-0.4-0.7-2.60.0-2.8-1.7-1.9-1.8-1.5-1.5
Pavlov. Cond. response bias2.02.87.6-0.8-1.21.50.1-0.1-2.8-0.4-2.8-1.7-1.9-1.9-1.7-1.7
Time in closed arm before self-admin1.31.56.3-2.1-0.70.6-1.9-2.50.71.6-0.90.40.30.50.50.5
Time in closed arm after self-admin0.40.41.30.10.9-0.70.40.21.1-0.91.0-0.00.20.2-0.00.0
Time in open arm before self-admin0.70.81.9-0.50.7-0.8-0.6-0.20.90.61.41.11.00.81.11.0
Time in open arm after self-admin1.21.33.0-0.60.6-0.8-1.3-0.70.61.60.91.71.41.31.31.3
Bone: periosteal estimation0.71.56.02.22.5-2.40.90.60.4-0.3-0.01.00.4-0.1-0.2-0.2
Bone: periosteal perimeter1.22.06.52.42.5-2.51.21.20.9-0.51.11.30.90.30.20.2
Bone: post-yield work0.60.91.20.8-0.60.61.00.9-0.8-1.1-0.8-1.0-1.0-1.1-1.1-1.1
Progressive ratio test 1 active lever presses1.01.01.70.4-1.01.11.11.3-0.9-1.3-0.3-1.2-1.1-1.1-1.0-0.9
Progressive ratio test 1 breakpoint0.50.51.10.0-0.70.90.71.0-0.5-0.90.2-0.9-0.7-0.7-0.6-0.5
Progressive ratio test 1 inactive lever presses2.72.94.70.4-2.02.21.61.7-1.5-2.0-1.0-1.9-1.9-1.8-1.8-1.8
Progressive ratio test 2 active lever presses0.80.91.9-0.2-1.01.20.70.6-0.7-0.8-0.8-1.4-1.2-1.2-1.0-1.0
Progressive ratio test 2 breakpoint1.21.32.70.1-1.21.31.00.8-0.7-1.0-1.1-1.6-1.4-1.5-1.3-1.3
Progressive ratio test 2 inactive lever presses2.02.34.6-0.2-2.02.10.90.5-1.2-1.1-1.8-2.0-1.8-1.7-1.5-1.5
Incentive Sensitization - Responses0.70.71.7-0.0-0.70.90.50.2-0.6-0.4-1.3-1.1-1.1-1.0-0.9-0.9
Incentive Sensitization - Breakpoint0.90.91.90.1-0.81.00.70.4-0.8-0.7-1.4-1.3-1.2-1.2-1.1-1.1
Sum of active levers in priming session hrs 5-60.00.00.1-0.2-0.10.2-0.10.1-0.30.0-0.20.0-0.10.0-0.0-0.0
Progressive ratio0.30.41.40.2-0.40.50.2-0.2-0.2-0.2-1.2-0.9-0.8-0.7-0.6-0.6
Food seeking constrained by brief footshock0.50.62.31.10.2-0.11.31.5-0.5-1.10.4-0.6-0.4-0.5-0.6-0.6
Seeking ratio, punishment vs. effort0.20.31.30.3-0.00.10.71.2-0.4-0.61.00.20.2-0.0-0.0-0.0
Retroperitoneal fat weight0.82.67.42.31.5-1.32.52.70.6-2.41.7-0.0-0.1-0.5-0.6-0.6
Reaction time number correct1.72.54.2-1.50.8-1.0-1.9-1.71.52.01.21.51.71.71.81.9
Reaction time mean minus median0.30.41.10.90.9-1.00.0-0.10.80.20.50.40.70.50.80.8
Reaction time mean minus median AUC0.40.61.21.01.0-1.10.40.41.1-0.20.90.20.50.40.80.7
Reaction time num false alarms1.01.42.20.31.1-1.2-0.8-0.91.31.11.01.41.51.51.41.4
Reaction time num false alarms AUC1.01.32.00.30.9-1.2-0.8-1.11.31.20.71.31.41.41.31.3
Reaction time trials correct on left1.72.54.2-1.50.8-1.0-1.9-1.71.52.01.21.51.71.71.81.9
Reaction time trials on left1.92.74.4-1.50.9-1.0-2.0-1.81.62.11.21.51.71.71.82.0
Reaction time mean0.00.00.1-0.2-0.20.1-0.2-0.40.20.3-0.2-0.00.10.00.10.1
Reaction time mean AUC0.00.00.1-0.3-0.10.0-0.2-0.30.40.3-0.0-0.10.10.10.20.2
Median of all reaction times0.10.10.4-0.6-0.60.5-0.3-0.4-0.10.3-0.5-0.2-0.1-0.1-0.1-0.1
Reaction time omissions0.50.62.2-0.10.1-0.4-0.8-1.01.50.80.40.30.70.81.01.0
Reaction time false alarm rate0.10.20.80.90.2-0.40.3-0.10.5-0.10.20.40.50.40.30.2
Reaction time premature initiation rate1.11.54.9-0.1-0.70.90.5-0.1-1.8-0.3-2.2-0.9-1.2-1.9-1.5-1.5
Reaction time premature initiations0.30.51.8-0.7-0.40.5-0.3-0.7-0.90.4-1.3-0.3-0.5-1.0-0.6-0.6
Std. dev. reaction times0.20.21.11.00.7-0.80.40.40.3-0.10.30.20.40.10.40.3
Reaction time trials completed1.92.74.4-1.50.9-1.0-2.0-1.81.62.11.21.51.71.71.82.0
Reaction time trials AUC1.52.13.6-1.30.9-1.0-1.8-1.61.41.91.11.31.51.51.61.7
Run reversals in cocaine runway, females2.32.22.9-1.41.2-1.2-1.6-1.31.21.51.71.51.51.71.61.6
Run reversals in cocaine runway, males0.50.41.61.01.2-1.30.20.11.00.30.20.40.40.20.20.2
Latency to leave start box in cocaine runway0.10.10.20.3-0.30.20.30.30.3-0.40.30.30.1-0.1-0.0-0.0
Latency to leave start box in cocaine runway, F0.20.30.7-0.7-0.20.0-0.6-0.80.60.50.30.60.50.40.40.4
Latency to leave start box in cocaine runway, M1.31.23.11.3-0.40.51.61.7-0.7-1.8-0.1-0.8-0.9-1.1-0.9-0.9
Std. dev. time between licks in bursts0.60.72.9-0.7-0.40.6-0.3-0.7-1.00.2-1.7-0.8-0.9-0.7-0.9-0.9
Total sessions with >9 infusions1.31.53.41.0-0.30.51.71.9-1.1-1.7-0.2-1.0-1.1-1.3-1.2-1.2
Short access day 1 total inactive lever presses2.02.33.21.6-0.60.71.71.6-1.5-1.6-1.4-1.5-1.6-1.7-1.8-1.7
Short access day 10 total inactive lever presses0.50.52.31.50.3-0.20.80.9-0.9-0.5-0.6-0.4-0.5-0.4-0.7-0.6
Short access day 1 total infusions2.12.24.11.4-0.70.81.92.0-1.5-1.9-0.6-1.4-1.5-1.4-1.6-1.6
Short access day 10 total infusions0.60.71.50.3-0.80.91.01.2-0.4-1.20.3-1.0-0.8-0.8-0.7-0.7
Short access total infusions2.83.16.21.3-1.31.52.32.5-1.7-2.4-0.4-1.7-1.7-1.8-1.7-1.7
Short access day 1 locomotion0.50.61.2-0.4-1.11.10.70.8-0.4-1.00.3-0.8-0.8-0.7-0.7-0.7
Short access day 10 total locomotion0.20.31.0-0.9-0.70.80.10.40.3-0.31.0-0.20.00.10.10.1
Short access total locomotion1.21.23.10.2-1.21.31.41.8-0.7-1.60.6-1.1-0.9-0.8-0.8-0.8
One hour access (0.3 mA shock)0.10.20.5-0.6-0.40.4-0.4-0.40.70.40.4-0.10.10.20.40.4
Compulsive drug intake0.60.62.6-0.4-0.30.1-1.1-1.60.51.3-1.10.30.30.40.40.3
One hour access (shock baseline)0.20.32.0-0.70.10.00.00.30.8-0.31.40.10.20.20.30.4
Social response proportion0.80.91.50.7-1.00.90.90.6-1.1-1.0-1.2-0.6-0.9-1.1-1.0-1.0
Social responses0.40.51.60.30.6-0.8-0.3-0.91.30.6-0.21.00.80.30.60.6
Social time0.50.72.4-1.5-0.90.8-1.1-1.31.00.9-0.0-0.00.10.60.50.5
Soleus weight0.20.51.6-0.1-0.70.90.10.1-1.2-0.4-1.0-0.9-0.8-0.5-0.6-0.7
Bone: stiffness1.11.73.41.5-0.50.51.81.8-1.1-1.7-0.5-1.0-1.2-1.5-1.4-1.5
Tibialis anterior weight0.31.04.9-1.0-2.21.9-0.6-0.8-0.50.3-1.0-0.7-0.4-0.2-0.3-0.3
Time to tail flick, vehicle, before self-admin0.20.20.80.90.5-0.7-0.1-0.40.30.3-0.60.10.10.10.10.1
Time to tail flick, vehicle, after self-admin3.13.34.7-0.51.8-2.0-1.9-2.02.12.20.82.01.91.91.91.8
Time to tail flick, test, before self-admin1.91.96.50.11.8-1.8-0.6-0.92.60.71.41.21.31.21.31.3
Time to tail flick, test, after self-admin0.90.92.3-1.50.4-0.4-1.3-1.20.91.00.80.70.71.00.90.9
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.4-0.00.0-0.2-0.40.50.3-0.20.30.1-0.00.10.0
Delta time to tail flick, test, before/after SA0.60.52.3-1.5-0.50.5-1.2-1.1-0.80.9-0.70.0-0.00.20.10.1
Tibia length0.61.73.51.91.7-1.21.51.5-1.8-1.0-0.9-0.4-0.8-1.2-1.1-1.2
Ambulatory time before self-admin0.70.72.8-0.5-1.71.70.60.6-0.4-0.9-0.1-0.7-0.8-0.6-0.5-0.6
Ambulatory time after self-admin0.40.52.0-0.00.5-0.40.0-0.4-0.50.1-1.4-0.9-0.7-0.9-0.8-0.9
Bone: tissue strength0.30.30.80.60.4-0.30.50.2-0.3-0.2-0.9-0.3-0.5-0.7-0.7-0.7
Total heroin consumption0.60.72.20.6-0.70.80.60.7-1.5-0.6-0.9-1.1-0.8-0.6-0.7-0.7
Bone: trabecular number0.30.51.3-0.50.2-0.3-0.6-0.30.30.61.20.90.80.80.90.9
Bone: trabecular spacing0.70.91.91.20.3-0.01.41.4-0.2-1.3-0.2-0.8-0.8-0.9-1.0-1.0
Bone: trabecular thickness0.20.21.1-0.5-1.00.8-0.4-0.3-0.40.30.00.10.10.10.10.1
Bone: trabecular tissue density0.91.23.9-0.6-1.81.6-0.4-0.9-1.20.3-2.0-1.0-1.0-0.8-0.8-0.8
Water consumed over 24 hours0.80.93.61.90.7-0.61.10.8-0.6-0.7-1.1-0.9-0.8-0.9-0.7-0.8
Number of responses in last shaping day1.11.23.6-1.1-1.81.90.3-0.1-0.6-0.7-1.0-1.3-1.1-0.9-0.9-0.9