Hub : Genes

Smarce1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Smarce1	0.02	0.01	1.2e-03	0.02	0.02	0.01	0.01	6.6e-03	3.9e-03	1.7e-02	3.6e-02
2	NAcc	gene expression	Smarce1	0.03	0.02	4.5e-03	0.02	0.01	0.01	0.02	6.1e-04	2.3e-02	4.4e-03	9.5e-04
3	Adipose	gene expression	Smarce1	0.05	0.04	8.9e-04	0.03	0.03	0.02	0.03	7.5e-04	5.6e-04	2.7e-03	5.1e-04
4	Adipose	mRNA stability	Smarce1	0.05	0.04	3.6e-03	0.02	0	0	0.01	3.9e-03	2.6e-01	2.8e-01	2.4e-02
5	Brain	gene expression	Smarce1	0.14	0.06	8.2e-09	0.05	0.09	0.09	0.08	1.5e-05	1.6e-08	4.3e-09	5.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.2	2.1	4.0	-1.4	-1.2	-2.0	-1.0	-1.4
Area under the delay curve	0.3	0.3	1.2	-1.1	0.2	-0.4	0.4	-0.1
BMI with tail	1.0	3.6	9.5	3.1	-1.5	1.3	-2.1	-0.5
BMI without tail	0.7	2.2	4.6	2.1	-1.5	0.8	-1.8	-0.7
Body weight	2.1	9.2	25.5	5.0	-2.5	2.7	-2.6	-0.2
Weight adjusted by age	0.9	1.4	3.4	0.1	-1.4	-0.3	-1.8	-1.1
Bone surface	1.1	2.0	4.7	0.5	-2.2	-0.9	-1.5	-1.4
Bone volume	1.7	3.1	6.0	0.5	-2.4	-1.2	-2.0	-1.9
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	-0.5	-0.5	-0.3	-0.2
Number of licking bursts	0.9	1.5	4.0	0.6	-2.0	-0.8	-1.3	-1.0
Context. condit. distance diff. score	2.2	2.6	4.6	0.0	2.0	1.2	2.2	1.7
Locomotion velocity, session 1	0.5	0.5	0.7	0.8	-0.8	-0.4	-0.8	-0.6
Locomotion distance, session 1	1.5	1.9	3.7	1.9	-1.9	0.5	-1.3	-0.8
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.1	0.0	0.0	0.2
Locomotion distance, session 2	1.3	1.8	4.0	0.8	-2.0	-0.2	-1.8	-1.0
Locomotion velocity, session 3	0.1	0.2	0.5	-0.5	0.1	-0.2	0.7	0.3
Locomotion distance, session 3	0.1	0.1	0.4	0.5	-0.6	0.3	-0.1	-0.0
Stereotopy head waving bouts, day 3	1.4	1.6	4.5	-2.1	1.1	-1.4	0.7	-0.3
Stereotopy head waving duration, day 3	0.2	0.3	0.6	-0.8	0.5	-0.5	0.2	-0.3
Locomotion velocity, session 7	1.1	1.2	2.6	1.6	-1.3	0.7	-1.0	-0.5
Locomotion distance, session 7	0.8	1.0	2.4	1.5	-0.7	1.5	-0.3	0.3
Stereotopy head waving bouts, day 7	0.8	0.9	2.1	-1.1	-0.5	-1.4	-0.3	-0.9
Stereotopy head waving duration, day 7	0.8	0.9	2.2	-1.2	-0.2	-1.5	-0.1	-0.9
Locomotion velocity, session 8	2.2	2.7	5.0	2.2	1.0	2.1	0.5	1.6
Locomotion distance, session 8	0.2	0.3	1.0	1.0	-0.5	0.6	-0.1	0.2
Degree of sensitization distance	1.2	1.3	3.2	1.4	0.3	1.8	0.2	1.0
Degree of sensitization stereotypy	0.8	0.9	2.1	-1.0	-0.5	-1.4	-0.5	-0.8
Conditioned locomotion	0.2	0.3	0.7	-0.8	0.2	-0.6	0.5	0.1
Cocaine response after cond. corrected	1.5	1.9	2.7	-0.6	-1.3	-1.4	-1.6	-1.6
Cocaine response after cond. not corrected	1.6	1.9	2.6	-0.5	-1.6	-1.2	-1.6	-1.6
Cocaine response before conditioning	0.2	0.2	0.5	0.1	-0.1	0.7	0.5	0.6
Saline control response	0.3	0.4	0.7	0.8	-0.8	0.6	-0.5	0.0
Bone: connectivity density	1.3	2.0	4.1	-1.8	-1.0	-2.0	-0.6	-1.2
Bone: cortical apparent density	2.6	3.5	8.1	-2.9	1.9	-1.5	1.9	0.2
Bone: cortical area	0.1	0.1	0.4	-0.1	-0.6	-0.3	-0.1	-0.3
Bone: cortical porosity	1.3	1.4	2.0	-0.4	-1.3	-1.3	-1.2	-1.4
Bone: cortical porosity	1.2	1.3	1.9	-0.1	-1.4	-1.1	-1.4	-1.3
Bone: cortical thickness	0.5	0.9	2.6	-1.6	0.4	-0.8	0.9	0.3
Bone: cortical thickness	2.6	3.0	9.3	-3.0	0.1	-2.3	0.8	-0.4
Bone: cortical tissue density	2.5	3.4	8.0	-2.8	1.9	-1.5	1.8	0.2
Condit. Reinf. active minus inactive responses	1.1	1.3	2.5	-1.6	1.4	-0.9	0.9	0.4
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.9	-1.7	1.4	-0.7	1.5	0.7
Condit. Reinf. active responses	0.9	1.1	2.1	-1.5	1.3	-1.0	0.7	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.1	-0.1	-0.6	-0.7	-0.5
Incentive salience index mean	0.6	0.7	2.2	-1.5	0.6	-0.9	0.4	0.1
Condit. Reinf. lever presses	0.2	0.2	0.5	-0.6	-0.7	-0.3	-0.5	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	-0.5	-1.1	-0.9	-0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.1	-0.3	-1.1	-0.4	-0.9	-0.7
Condit. Reinf. active responses	1.1	1.5	2.3	-0.7	-1.4	-1.5	-1.1	-1.2
Condit. Reinf. inactive responses	1.1	1.4	3.0	-0.9	-0.9	-1.7	-0.9	-1.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.5	-0.1	-0.5	0.3	-0.0
Condit. Reinf. lever reinforcers received	0.9	1.3	2.5	-1.0	-1.1	-1.6	-0.7	-1.1
Conditioned reinforcement - actives	0.1	0.2	0.7	0.2	0.1	0.8	0.4	0.2
Conditioned reinforcement - inactives	0.3	0.5	1.2	-0.1	1.1	0.7	0.7	0.6
Conditioned locomotion	0.2	0.3	0.9	-0.0	-1.0	-0.1	-0.5	-0.6
Patch foraging indifference point 0 sec	0.3	0.6	1.2	-0.9	0.1	0.4	1.1	0.8
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.0	-0.3	-0.5	-0.3	-0.5
Delay disc. indifference point, 0s delay	0.6	0.6	1.4	-1.2	-0.4	-1.0	0.0	-0.8
Delay disc. indifference point, 16s delay	1.8	2.0	3.4	-1.8	1.7	-0.7	1.7	0.7
Delay disc. indifference point, 2s delay	0.9	1.0	1.7	-0.5	-1.3	-0.9	-0.9	-1.3
Delay disc. indifference point, 24s delay	0.5	0.6	1.1	0.1	0.8	0.8	0.8	1.1
Delay disc. indifference point, 4s delay	0.9	0.9	2.4	-1.6	-0.3	-1.1	-0.1	-0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.1	-0.5	0.2	0.1	0.2
Indifference point function ln k	0.4	0.8	1.8	-0.4	0.9	0.7	1.3	0.8
Indifference point function log k	0.4	0.8	1.8	-0.4	0.9	0.7	1.3	0.8
Patch foraging total patch changes 0 sec	0.3	0.5	1.0	-0.5	0.0	0.7	1.0	0.9
Patch foraging total patch changes 12 sec	1.6	2.1	3.2	-1.3	-1.8	-1.6	-0.8	-1.6
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	0.1	-0.5	-0.2	0.2	-0.1
Patch foraging total patch changes 24 sec	0.3	0.5	0.8	-0.9	-0.9	-0.8	-0.0	-0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.8	-0.3	0.2	0.3	0.1
Patch foraging time to switch 0 sec	0.1	0.3	0.4	-0.2	-0.6	-0.5	-0.7	-0.5
Patch foraging water rate 0 sec	0.1	0.1	0.3	-0.3	0.3	0.1	0.5	0.4
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.1	-0.2	-0.3	0.5	0.2
Patch foraging water rate 18 sec	0.9	1.4	3.5	-0.6	-1.9	-1.2	-0.6	-1.1
Patch foraging water rate 24 sec	0.1	0.2	0.3	-0.4	-0.5	-0.3	0.3	-0.4
Patch foraging water rate 6 sec	0.7	1.0	2.3	-1.5	-0.5	-1.4	-0.0	-0.8
Seeking ratio, delayed vs. immediate footshock	2.3	2.8	6.3	-1.0	2.5	0.0	2.2	1.5
Distance traveled before self-admin	0.3	0.5	1.2	-0.4	-0.4	-0.5	-1.1	-0.7
Distance traveled after self-admin	0.1	0.1	0.2	0.3	0.4	0.1	-0.4	0.1
Extensor digitorum longus weight	3.5	13.9	29.3	5.4	1.0	5.2	1.0	3.4
Bone: elastic displacement	0.2	0.2	0.5	0.5	0.2	0.7	0.2	0.4
Bone: elastic work	0.4	0.5	0.9	-0.3	-0.7	-0.9	-0.5	-0.9
Bone: endosteal estimation	1.8	3.9	8.1	2.8	-2.3	0.9	-2.0	-1.1
Bone: endosteal perimeter	0.8	1.8	5.3	2.3	-1.2	1.0	-1.0	-0.4
Epididymis fat weight	0.3	0.9	2.1	0.8	-1.5	0.4	-1.1	-0.5
Delta time in closed arm before/after self-admin	0.6	0.6	2.3	1.5	0.2	0.7	-0.2	0.4
Delta time in open arm before/after self-admin	0.4	0.4	1.3	-0.5	1.1	-0.0	0.4	0.6
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.2	-0.7	-0.5	-0.5	-0.4
Delay discount exponential model param	0.2	0.3	1.0	1.0	-0.3	0.2	-0.5	-0.0
Extinction: sum of active levers before priming	0.6	0.7	1.8	1.4	-0.7	0.9	-0.5	0.4
Active lever presses in extinction session 6	5.1	5.1	8.6	-0.5	-2.6	-1.8	-2.9	-2.6
Bone: final force	1.6	2.5	4.7	-0.1	-2.2	-1.1	-1.6	-2.0
Bone: final moment	1.4	2.2	4.0	0.0	-2.0	-1.0	-1.6	-1.9
Food consumed during 24 hour testing period	0.3	0.4	1.0	1.0	-0.4	0.9	-0.0	0.3
Glucose	0.8	1.2	3.3	0.4	-1.8	-0.8	-0.7	-1.3
Heart weight	1.4	2.1	5.2	2.3	-0.3	2.0	0.0	1.0
Delay discount hyperbolic model param	0.2	0.2	0.8	0.9	-0.2	0.1	-0.4	0.0
Intermittent access intake day 1-15 change	0.5	1.0	3.3	-1.0	0.4	-1.8	0.1	-0.6
Intermittent access intake escalation	0.4	0.9	2.8	-0.9	0.5	-1.7	0.2	-0.6
Intermittent access intake escalation 2	0.2	0.2	0.7	0.2	0.0	-0.8	-0.2	-0.4
Intermitt. access day 1 inactive lever presses	0.4	1.7	4.8	-2.2	0.3	-1.6	0.4	-0.8
Intermitt. access day 15 inactive lever presses	0.7	1.3	2.5	-1.6	1.4	-0.5	1.3	0.5
Intermitt. access escalation Index	0.2	0.2	0.6	0.5	-0.8	-0.2	-0.3	-0.3
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.1	0.5	0.5	0.4	0.3
Intermittent access day 15 total infusions	0.5	0.8	1.2	-1.0	1.1	-0.9	0.9	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.0	-1.0	1.0	-0.8	0.8	-0.1
Intermittent access total infusions	0.5	0.6	1.2	-0.8	1.1	-0.4	0.9	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.2	0.1	0.5	0.4	0.1
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.0	-0.5	-0.4	-0.5	-0.6
Intermittent access total locomotion	0.2	0.3	0.6	-0.8	0.5	-0.6	0.4	-0.3
Intermittent access standard deviation	0.7	1.5	3.1	-1.8	1.2	-1.7	0.6	-0.3
Left kidney weight	0.0	0.1	0.3	0.2	-0.3	-0.5	-0.1	0.1
Right kidney weight	0.4	1.7	2.6	-0.2	-1.6	-1.3	-1.5	-1.4
Cocaine induced anxiety	0.3	0.5	1.3	1.1	-0.3	0.6	-0.8	0.3
Post-drug Anxiety	0.4	0.5	1.1	0.3	0.9	0.6	0.0	1.0
Baseline Anxiety	0.3	0.3	0.7	-0.8	0.8	0.1	0.4	0.5
Tail length	0.1	0.4	0.9	0.6	0.0	1.0	0.3	0.7
Length with tail	0.5	2.2	6.0	2.4	-1.3	1.6	-0.8	0.3
Length without tail	1.2	3.7	10.2	3.2	-1.8	2.0	-1.0	0.3
Times rat made contact with spout	0.1	0.2	0.4	-0.1	-0.4	-0.2	-0.6	-0.5
Lifetime Intake	0.6	0.8	1.4	-1.0	1.2	-0.3	1.1	0.2
Liver weight, left	0.5	0.8	1.6	1.1	-1.3	0.7	-0.8	-0.3
Liver weight, right	0.6	1.0	2.5	-1.6	-0.1	-1.4	0.1	-0.7
Locomotor activity	1.6	2.5	4.6	-0.3	-2.1	-1.5	-1.5	-1.9
Locomotor testing distance	0.9	1.7	3.5	-1.5	-0.9	-1.9	-0.5	-1.2
Locomotor testing rearing	1.5	3.0	9.2	-3.0	0.2	-2.0	0.9	-0.7
Locomotion in novel chamber	1.3	1.6	4.8	-2.2	0.3	-1.4	-0.5	-0.9
Locomotion in novel chamber post-restriction	0.6	0.9	2.3	-0.1	-0.7	-0.5	-1.5	-1.2
Fecal boli incidents, locomotor time 1	0.2	0.3	1.0	1.0	0.2	0.5	-0.4	0.3
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	-0.4	-0.8	-0.6	0.2	-0.6
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.3	-0.5	0.4	0.2	1.1	0.8
Bouts of movement, locomotor time 1	0.2	0.2	0.7	0.4	-0.1	0.1	-0.8	-0.1
Total resting periods, locomotor time 1	0.5	0.5	1.1	1.0	-0.3	0.6	-1.0	-0.1
Rest time, locomotor task time 1	0.6	0.8	1.2	0.8	-1.1	0.7	-0.9	-0.8
Distance moved, locomotor task time 1	0.3	0.5	0.8	-0.9	0.9	-0.7	0.5	0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.2	-0.0	0.0	0.4	0.3
Time >=10cm from walls, locomotor time 2	0.7	1.1	3.2	-0.5	-1.8	-1.1	-0.3	-0.9
Bouts of movement, locomotor time 2	0.2	0.3	0.6	-0.8	-0.6	-0.4	0.4	0.0
Total resting periods, locomotor time 2	0.1	0.2	0.5	-0.7	-0.3	-0.2	0.6	0.2
Rest time, locomotor task time 2	0.5	0.6	1.5	1.0	-0.4	1.2	-0.4	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	-0.3	-0.3	-0.2	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.4	0.2	0.3	0.4	0.6
Light reinforcement 1	0.6	1.4	3.2	-1.8	-0.7	-1.5	-0.1	-0.9
Light reinforcement 2	0.8	1.2	1.9	-0.5	-1.4	-1.1	-1.0	-1.2
Bone: marrow area	1.6	3.6	7.6	2.8	-2.2	0.9	-1.9	-1.0
Bone: maximum diameter	0.3	0.5	0.9	0.2	-1.0	-0.5	-0.9	-0.8
Bone: maximum force	0.8	1.4	3.7	0.6	-1.9	-0.4	-1.1	-1.3
Bone: maximum moment	0.7	1.2	2.9	0.8	-1.7	-0.2	-1.0	-1.1
Mean time between licks in bursts	0.7	1.6	5.2	2.3	-0.9	1.4	-0.4	0.1
Mean num. licks in bursts	0.7	1.0	3.2	-0.7	1.8	0.6	0.8	0.7
Cd content in liver	1.1	1.3	2.6	1.2	1.2	1.6	0.1	0.8
Co content in liver	2.2	2.6	3.9	1.0	2.0	2.0	1.0	1.8
Cu content in liver	1.0	1.2	3.0	-0.8	1.7	0.1	0.8	1.2
Fe content in liver	0.8	1.0	2.0	1.4	-1.1	0.9	-1.0	0.1
K content in liver	2.0	2.0	5.1	-2.0	0.0	-2.3	0.3	-0.8
Mg content in liver	2.7	2.8	4.9	-2.2	1.9	-1.6	1.6	0.4
Mn content in liver	1.5	1.7	3.0	-1.7	0.7	-1.7	1.4	-0.1
Na content in liver	2.8	3.0	4.3	-0.5	-1.8	-2.0	-1.8	-2.1
Rb content in liver	0.4	0.5	1.0	-1.0	0.8	-0.1	0.6	0.6
Se content in liver	4.1	4.9	13.0	-3.6	0.8	-3.1	0.5	-0.9
Sr content in liver	1.3	1.1	3.0	-0.3	1.2	0.4	1.7	1.0
Zn content in liver	1.9	2.1	6.3	-2.5	1.2	-1.6	0.1	-0.2
Bone: minimum diameter	0.3	0.6	1.2	1.1	-1.0	0.1	-0.8	-0.5
Time in familiar zone, hab. session 1	2.6	2.5	4.1	0.1	-1.9	-1.2	-1.8	-2.0
Time in novel zone, hab. session 1	2.5	2.5	5.6	-1.0	2.4	0.4	1.9	1.4
Total zone transitions, hab. session 1	0.8	1.2	2.8	1.1	0.7	1.7	0.3	1.1
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.5	0.8	0.3	0.8	0.6
Locomotion velocity, hab. session 1	0.2	0.2	0.4	-0.2	0.4	0.4	0.5	0.6
Time in familiar zone, hab. session 2	1.6	1.6	4.2	-1.1	-0.2	-2.1	-0.7	-1.5
Time in novel zone, hab. session 2	0.4	0.4	0.9	0.1	0.2	1.0	0.6	0.8
Total zone transitions, hab. session 2	0.6	0.8	2.0	1.4	-0.4	1.4	-0.2	0.3
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.9	-0.4	0.8	-0.5	-0.2
Locomotion velocity, hab. session 2	0.3	0.5	1.1	1.0	-0.5	0.9	-0.4	-0.1
Novel to familiar place preference ratio	0.4	0.4	0.9	-0.0	0.9	0.3	0.7	0.8
Novelty place preference	0.7	0.7	1.5	-0.2	1.2	0.5	1.0	1.0
Time in novel zone, NPP test	0.5	0.6	1.2	-0.5	1.1	0.1	0.9	0.8
Total zone transitions, NPP test	1.3	1.9	3.4	1.8	-1.8	1.1	-1.2	-0.4
Total locomotion distance, NPP test	0.6	0.8	1.8	1.0	-1.4	0.6	-0.9	-0.5
Locomotion velocity, NPP test	0.6	0.9	1.9	1.4	-1.0	1.2	-0.6	-0.0
Intraocular pressure	3.1	4.4	10.3	2.3	1.5	3.2	0.0	2.1
Delta distance traveled before/after self-admin	0.5	0.6	1.0	0.6	1.0	0.4	0.7	0.8
Delta ambulatory time before/after self-admin	0.2	0.2	1.1	1.0	-0.0	0.2	-0.1	0.1
Parametrial fat weight	0.7	1.7	3.0	-0.5	-1.4	-0.9	-1.7	-1.6
Pavlov. Cond. lever latency	1.5	1.9	3.6	0.5	1.9	0.7	1.9	1.2
Pavlov. Cond. magazine entry latency	3.7	4.7	8.5	-2.7	-1.2	-2.9	-1.5	-2.1
Pavlov. Cond. change in total contacts	2.4	2.6	9.5	-3.1	0.8	-1.6	0.5	-0.2
Pavlov. Cond. index score	2.5	3.1	4.1	-2.0	-1.4	-1.9	-1.7	-1.7
Pavlov. Cond. latency score	2.3	2.9	3.4	-1.6	-1.6	-1.7	-1.9	-1.7
Pavlov. Cond. lever contacts	1.7	2.0	4.0	-0.6	-1.8	-0.8	-2.0	-1.3
Pavlov. Cond. magazine entry number	3.4	4.3	10.4	3.2	0.4	2.8	0.8	1.6
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.3	0.7	1.1	0.9	0.8	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.3	5.2	-2.3	-1.3	-2.1	-1.6	-1.7
Pavlov. Cond. response bias	2.7	3.4	7.6	-2.8	-0.9	-2.3	-0.9	-1.5
Pavlov. Cond. lever latency	0.5	0.6	0.9	0.5	1.0	1.0	0.4	1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.5	0.0	-0.4	0.5	-0.2
Pavlov. Cond. index score	0.2	0.3	0.5	0.0	-0.7	-0.5	-0.4	-0.7
Pavlov. Cond. latency score	0.2	0.2	0.5	0.1	-0.7	-0.4	-0.4	-0.7
Pavlov. Cond. lever contacts	0.5	0.7	1.3	-0.3	-1.1	-0.9	-0.6	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.2	0.3	0.6	0.2	0.6
Pavlov. Cond. intertrial magazine entries	1.8	2.7	4.6	0.7	1.4	2.1	1.5	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.1	-0.6	-0.3	-0.3	-0.6
Pavlov. Cond. response bias	0.7	1.0	1.6	-0.7	-1.0	-1.3	-0.6	-1.2
Time in closed arm before self-admin	0.8	1.1	2.4	-1.5	0.7	-0.9	1.3	-0.1
Time in closed arm after self-admin	1.1	1.2	3.5	-0.6	1.0	-0.7	1.9	0.7
Time in open arm before self-admin	0.6	0.6	1.4	1.0	-1.2	0.4	-0.6	-0.4
Time in open arm after self-admin	0.2	0.2	0.6	0.4	0.2	0.8	-0.1	0.3
Bone: periosteal estimation	0.8	1.7	3.4	1.3	-1.8	-0.1	-1.4	-1.1
Bone: periosteal perimeter	1.0	1.7	3.1	1.7	-1.8	0.3	-1.3	-0.9
Bone: post-yield work	0.6	0.9	2.1	1.5	-0.8	1.2	0.1	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.5	0.3	-0.2	0.3	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	0.3	-0.1	0.4	-0.1
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.9	-0.9	0.5	0.1	0.8	0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.7	-0.8	0.3	-0.3	0.1	-0.2
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	-0.8	0.2	-0.5	0.1	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.4	0.6	0.1	0.3	0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	-0.2	-0.0	-0.5	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.4	-0.2	-0.1	-0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.7	0.6	1.1	-0.6	-0.7	-1.0	-0.7	-0.8
Progressive ratio	0.4	0.6	1.0	-0.3	-1.0	-0.7	-0.8	-0.8
Food seeking constrained by brief footshock	0.8	1.0	1.5	-0.5	-1.0	-1.2	-0.9	-1.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	0.0	0.6	0.1	0.5	0.2
Retroperitoneal fat weight	0.0	0.1	0.5	-0.2	-0.7	-0.1	-0.2	-0.2
Reaction time number correct	0.3	0.7	1.8	1.3	-1.0	0.7	-0.2	-0.3
Reaction time mean minus median	0.4	0.9	2.3	1.0	0.8	1.5	-0.0	0.8
Reaction time mean minus median AUC	0.2	0.5	1.0	0.5	0.7	1.0	-0.1	0.7
Reaction time num false alarms	1.2	1.7	3.8	0.2	-1.9	-1.2	-1.2	-1.4
Reaction time num false alarms AUC	1.3	2.1	5.2	0.5	-2.3	-1.0	-1.3	-1.5
Reaction time trials correct on left	0.3	0.7	1.8	1.3	-1.0	0.7	-0.2	-0.3
Reaction time trials on left	0.4	0.7	1.7	1.3	-1.0	0.7	-0.2	-0.3
Reaction time mean	0.6	1.0	2.5	-1.1	1.6	-0.4	0.8	0.6
Reaction time mean AUC	0.7	1.1	2.7	-1.3	1.7	-0.5	0.8	0.6
Median of all reaction times	1.2	1.7	3.7	-1.9	1.6	-1.2	0.9	0.3
Reaction time omissions	0.1	0.1	0.5	-0.7	0.3	-0.4	-0.0	-0.1
Reaction time false alarm rate	1.0	1.3	2.3	-0.3	-1.5	-1.4	-1.0	-1.2
Reaction time premature initiation rate	1.1	1.5	3.0	-1.7	0.1	-1.7	-0.5	-1.1
Reaction time premature initiations	0.3	0.5	0.8	-0.7	-0.3	-0.9	-0.4	-0.9
Std. dev. reaction times	0.1	0.2	0.7	0.1	0.8	0.5	-0.1	0.4
Reaction time trials completed	0.4	0.7	1.7	1.3	-1.0	0.7	-0.2	-0.3
Reaction time trials AUC	0.3	0.6	1.7	1.3	-0.9	0.7	-0.0	-0.1
Run reversals in cocaine runway, females	2.6	2.5	4.6	-0.1	1.8	1.1	1.9	2.2
Run reversals in cocaine runway, males	0.2	0.2	0.7	-0.5	0.8	-0.0	0.1	-0.1
Latency to leave start box in cocaine runway	0.4	0.5	0.9	1.0	0.3	0.7	0.8	0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	0.8	0.9	0.5	0.7	0.3	0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.9	-0.1	0.0	-0.2	1.0	0.1
Std. dev. time between licks in bursts	0.5	0.6	1.6	0.9	-1.3	-0.3	-0.7	-0.6
Total sessions with >9 infusions	1.3	1.5	3.8	-1.1	1.5	-0.1	2.0	0.7
Short access day 1 total inactive lever presses	0.6	0.8	2.1	-1.5	1.1	-0.1	0.7	0.0
Short access day 10 total inactive lever presses	0.1	0.3	0.5	0.1	0.5	0.7	0.3	0.6
Short access day 1 total infusions	1.3	1.8	3.3	-1.7	1.5	-0.5	1.8	0.4
Short access day 10 total infusions	0.2	0.3	0.8	-0.9	0.4	-0.5	0.6	-0.2
Short access total infusions	0.7	0.9	2.0	-1.4	1.0	-0.6	1.1	0.1
Short access day 1 locomotion	0.7	0.9	2.3	-1.5	0.2	-0.8	1.1	-0.1
Short access day 10 total locomotion	0.2	0.5	0.8	-0.5	-0.5	-0.8	-0.4	-0.9
Short access total locomotion	0.1	0.1	0.5	-0.3	0.0	-0.1	0.7	-0.0
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.2	0.5	0.6	0.6	0.4
Compulsive drug intake	3.5	4.2	7.8	-0.2	2.6	1.3	2.8	2.2
One hour access (shock baseline)	0.2	0.3	0.5	-0.4	-0.4	-0.6	-0.4	-0.7
Social response proportion	0.0	0.1	0.1	0.3	-0.1	0.2	-0.1	0.3
Social responses	0.5	0.7	1.6	0.2	-1.3	-0.3	-1.1	-0.8
Social time	1.4	1.9	4.5	1.1	-1.4	0.4	-2.1	-1.1
Soleus weight	1.3	3.7	7.6	1.2	-2.8	-0.6	-2.3	-1.9
Bone: stiffness	0.5	0.8	2.0	-0.1	-1.4	-0.6	-0.7	-1.0
Tibialis anterior weight	0.4	1.2	3.8	1.9	-0.6	1.2	-0.8	0.3
Time to tail flick, vehicle, before self-admin	0.7	0.8	2.1	1.1	-0.3	1.5	-0.5	-0.1
Time to tail flick, vehicle, after self-admin	0.7	0.9	2.4	0.6	-1.1	0.7	-1.5	-0.3
Time to tail flick, test, before self-admin	0.3	0.3	0.7	0.8	-0.1	0.5	-0.6	0.1
Time to tail flick, test, after self-admin	0.8	0.9	1.5	0.9	-1.1	0.4	-1.2	-0.7
Delta time to tail flick, vehicle, before/after SA	2.0	1.9	4.4	0.0	-1.7	-0.7	-2.1	-1.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.6	-0.5	-0.2	-0.2	-0.6
Tibia length	0.8	2.1	4.9	2.2	-1.3	1.1	-1.6	-0.5
Ambulatory time before self-admin	0.0	0.1	0.1	-0.3	0.3	0.0	-0.4	0.1
Ambulatory time after self-admin	0.3	0.4	0.8	0.9	0.1	0.3	-0.9	-0.1
Bone: tissue strength	1.2	1.2	2.7	1.6	-0.3	1.6	0.4	0.7
Total heroin consumption	3.5	4.0	6.4	-0.8	-2.5	-1.7	-2.2	-2.3
Bone: trabecular number	2.9	4.8	8.6	-2.2	-1.8	-2.9	-1.6	-2.3
Bone: trabecular spacing	0.9	1.2	3.0	1.7	-0.6	1.2	-1.1	-0.0
Bone: trabecular thickness	0.2	0.2	0.4	0.2	-0.6	-0.6	-0.3	-0.5
Bone: trabecular tissue density	1.7	2.5	5.0	-0.6	1.8	1.3	2.2	1.5
Water consumed over 24 hours	0.3	0.5	1.1	1.0	-1.0	0.4	-0.2	-0.2
Number of responses in last shaping day	1.5	1.7	3.7	-0.8	1.9	-0.2	1.9	0.7