Hub : Genes

Smarcd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_063263961.1 0.04 0.03 9.9e-05 0.02 0.03 0.02 0.02 2.5e-03 7.0e-04 1.5e-03 1.7e-03
2 PL isoform ratio XM_063263961.1 0.04 0.03 9.4e-05 0.01 0.03 0.03 0.02 7.1e-03 3.6e-04 8.5e-04 1.3e-03
3 PL alternative TSS NM_001108752.1 0.04 0.03 3.0e-05 0.02 0.03 0.03 0.03 2.8e-03 1.5e-04 7.3e-04 6.9e-04
4 PL isoform ratio NM_001108752.1 0.04 0.03 3.5e-05 0.02 0.03 0.03 0.03 4.4e-03 1.4e-04 3.8e-04 7.7e-04
5 Brain mRNA stability Smarcd1 0.04 0.03 2.1e-04 0.03 0.03 0.03 0.02 1.3e-03 4.4e-04 1.5e-03 3.6e-03
6 Brain gene expression Smarcd1 0.17 0.1 0.0e+00 0.21 0.22 0.21 0.21 1.1e-19 2.7e-20 2.5e-19 1.2e-19
7 PL gene expression Smarcd1 0.06 0.05 3.8e-06 0.06 0.05 0.05 0.06 5.2e-07 1.3e-06 2.2e-06 9.6e-07
8 NAcc mRNA stability Smarcd1 0.08 0.05 9.7e-12 0.09 0.08 0.08 0.08 3.9e-13 1.4e-12 5.6e-12 1.6e-12
9 Liver isoform ratio NM_001108752.1 0.02 0.02 6.4e-03 0.02 0.01 0.01 0.01 5.5e-03 7.7e-03 1.1e-02 9.1e-03
10 NAcc gene expression Smarcd1 0.28 0.15 0.0e+00 0.35 0.34 0.34 0.34 2.0e-54 9.3e-54 3.0e-53 2.7e-54
11 Liver alternative TSS NM_001108752.1 0.03 0.03 3.6e-03 0.02 0.02 0.02 0.02 3.6e-03 4.9e-03 6.0e-03 4.8e-03
12 BLA gene expression Smarcd1 0.29 0.15 1.1e-07 0.15 0.14 0.14 0.14 2.5e-08 1.2e-07 1.3e-07 6.8e-08
13 Liver gene expression Smarcd1 0.47 0.28 2.9e-03 0.01 0.01 0.01 0.01 9.8e-03 1.6e-02 7.6e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density6.811.815.23.93.9-3.8-3.83.73.73.2-3.33.23.43.43.3-1.0
Area under the delay curve1.01.22.61.01.0-1.0-1.01.11.11.3-1.01.11.01.01.60.3
BMI with tail6.020.624.95.05.0-5.0-4.94.94.94.6-4.54.54.64.54.1-0.0
BMI without tail1.54.55.32.32.3-2.3-2.32.32.31.9-2.12.22.22.21.80.2
Body weight6.227.232.45.75.7-5.7-5.75.65.65.2-5.35.35.35.34.70.3
Weight adjusted by age0.81.32.21.41.3-1.3-1.21.21.11.1-0.70.71.01.00.6-1.5
Bone surface8.715.820.24.54.4-4.4-4.44.34.33.9-3.93.93.83.83.8-0.8
Bone volume7.813.916.94.14.1-4.1-4.14.04.03.5-3.83.73.73.73.8-0.1
Breakpoint value in progressive ratio session0.70.91.51.11.1-1.1-1.01.00.91.2-0.70.61.00.90.5-0.8
Number of licking bursts0.91.52.6-1.1-1.11.11.1-1.1-1.2-1.61.4-1.0-1.3-1.3-1.3-0.6
Context. condit. distance diff. score0.20.20.40.60.5-0.5-0.50.50.50.2-0.40.60.50.50.4-0.1
Locomotion velocity, session 13.43.75.0-1.7-1.71.81.8-1.9-1.9-1.92.1-2.2-2.0-1.9-2.1-1.8
Locomotion distance, session 12.73.43.8-1.9-1.91.91.9-1.9-1.9-1.91.9-1.9-1.9-1.9-1.9-0.5
Locomotion velocity, session 20.30.30.4-0.6-0.60.60.6-0.6-0.6-0.40.6-0.7-0.5-0.5-0.6-0.2
Locomotion distance, session 22.73.74.3-2.0-2.02.02.0-2.1-2.1-1.72.1-2.1-2.0-1.9-2.0-0.6
Locomotion velocity, session 34.75.46.4-2.4-2.42.42.4-2.4-2.4-2.52.3-2.3-2.4-2.3-2.3-0.4
Locomotion distance, session 33.23.44.7-2.2-2.12.12.1-2.1-2.0-1.91.7-1.7-1.7-1.5-1.70.8
Stereotopy head waving bouts, day 30.20.21.60.50.5-0.5-0.40.40.30.3-0.1-0.00.20.20.1-1.3
Stereotopy head waving duration, day 30.10.21.90.30.2-0.2-0.20.10.10.20.2-0.3-0.0-0.1-0.1-1.4
Locomotion velocity, session 72.32.53.4-1.4-1.41.41.5-1.5-1.6-1.61.8-1.9-1.6-1.5-1.8-1.6
Locomotion distance, session 73.44.35.0-2.1-2.12.12.1-2.1-2.2-2.12.2-2.2-2.1-2.2-2.2-0.9
Stereotopy head waving bouts, day 70.80.91.21.11.1-1.1-1.01.01.00.8-1.00.80.80.91.0-0.3
Stereotopy head waving duration, day 71.01.21.51.21.2-1.2-1.21.21.21.0-1.21.01.11.11.2-0.0
Locomotion velocity, session 80.30.41.4-0.4-0.40.40.5-0.5-0.5-0.80.6-0.9-0.5-0.5-0.7-1.2
Locomotion distance, session 81.11.62.0-1.3-1.31.31.3-1.3-1.3-1.41.3-1.2-1.3-1.3-1.3-0.3
Degree of sensitization distance0.10.10.50.30.3-0.3-0.30.20.20.20.00.0-0.0-0.2-0.0-0.7
Degree of sensitization stereotypy0.50.50.90.60.6-0.6-0.70.70.70.6-1.00.80.70.81.00.8
Conditioned locomotion0.10.10.2-0.1-0.20.20.2-0.2-0.2-0.50.3-0.2-0.4-0.4-0.2-0.5
Cocaine response after cond. corrected0.00.00.0-0.1-0.10.10.1-0.1-0.00.00.0-0.10.00.0-0.00.0
Cocaine response after cond. not corrected0.30.30.5-0.7-0.70.70.6-0.6-0.6-0.60.5-0.5-0.4-0.4-0.50.3
Cocaine response before conditioning2.32.73.5-1.9-1.81.81.8-1.8-1.7-1.81.6-1.4-1.5-1.5-1.50.6
Saline control response0.00.10.40.0-0.00.00.0-0.1-0.1-0.30.3-0.1-0.1-0.1-0.3-0.6
Bone: connectivity density3.75.78.02.82.8-2.8-2.72.62.52.2-2.22.12.22.22.2-1.4
Bone: cortical apparent density0.10.20.3-0.4-0.40.40.4-0.4-0.4-0.40.4-0.5-0.2-0.2-0.30.1
Bone: cortical area6.610.213.63.73.6-3.6-3.63.53.43.2-3.02.93.03.03.0-1.3
Bone: cortical porosity0.10.11.4-0.2-0.10.10.1-0.1-0.0-0.1-0.20.5-0.00.00.01.2
Bone: cortical porosity0.20.21.4-0.4-0.30.30.3-0.3-0.2-0.30.00.2-0.2-0.2-0.11.2
Bone: cortical thickness2.13.44.72.22.1-2.1-2.12.02.01.7-1.71.61.81.81.8-1.0
Bone: cortical thickness0.10.20.7-0.2-0.30.30.3-0.3-0.3-0.00.5-0.5-0.3-0.3-0.6-0.8
Bone: cortical tissue density0.20.20.4-0.5-0.50.50.5-0.5-0.5-0.50.5-0.6-0.3-0.4-0.40.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.30.30.3-0.3-0.3-0.50.3-0.2-0.4-0.3-0.4-0.2
Condit. Reinf. active-inactive response ratio0.20.20.30.50.5-0.5-0.50.50.50.2-0.30.50.20.30.3-0.4
Condit. Reinf. active responses0.70.81.0-1.0-1.01.01.0-1.0-1.0-1.00.9-0.9-0.9-0.8-1.0-0.2
Condit. Reinf. inactive responses2.63.14.0-2.0-2.02.02.0-1.9-1.9-1.71.8-1.9-1.5-1.5-1.80.1
Incentive salience index mean0.00.00.00.10.1-0.1-0.10.10.0-0.2-0.00.1-0.00.0-0.0-0.1
Condit. Reinf. lever presses0.30.40.60.60.6-0.6-0.60.60.60.6-0.70.80.80.70.60.6
Condit. Reinf. active minus inactive responses0.60.82.20.60.6-0.7-0.70.70.80.5-0.91.10.80.81.21.5
Condit. Reinf. active-inactive response ratio0.50.63.60.30.3-0.3-0.40.50.50.4-0.80.90.60.61.11.9
Condit. Reinf. active responses0.10.11.2-0.00.0-0.0-0.10.10.10.1-0.30.40.30.30.41.1
Condit. Reinf. inactive responses0.60.81.1-0.9-1.01.01.0-0.9-0.9-0.80.9-1.0-0.7-0.7-1.0-0.1
Condit. Reinf. lever presses0.00.00.10.10.1-0.1-0.10.10.1-0.00.1-0.00.30.3-0.0-0.1
Condit. Reinf. lever reinforcers received0.10.10.9-0.4-0.40.40.3-0.3-0.3-0.40.10.0-0.1-0.1-0.00.9
Conditioned reinforcement - actives0.50.81.3-1.2-1.11.11.1-1.0-1.0-0.60.8-0.7-0.6-0.6-0.80.7
Conditioned reinforcement - inactives3.95.77.1-2.7-2.62.62.6-2.6-2.6-2.32.4-2.3-2.3-2.4-2.30.1
Conditioned locomotion0.20.30.8-0.6-0.60.60.6-0.6-0.6-0.60.6-0.5-0.7-0.90.00.0
Patch foraging indifference point 0 sec5.09.212.6-2.9-2.92.93.0-3.0-3.1-3.53.3-3.0-3.3-3.3-3.1-1.7
Patch foraging indifference point AUC0.71.01.3-1.2-1.11.11.1-1.1-1.1-1.00.9-1.0-0.8-0.8-0.70.3
Delay disc. indifference point, 0s delay1.82.02.41.41.5-1.5-1.51.51.51.3-1.51.51.41.41.30.7
Delay disc. indifference point, 16s delay0.80.91.70.90.9-0.9-0.90.90.91.3-0.90.90.90.91.30.1
Delay disc. indifference point, 2s delay1.71.93.31.41.4-1.4-1.41.41.41.4-1.31.51.31.31.80.3
Delay disc. indifference point, 24s delay0.50.61.20.80.8-0.8-0.80.80.80.9-0.70.70.60.51.1-0.5
Delay disc. indifference point, 4s delay1.31.42.91.01.0-1.0-1.11.11.11.4-1.21.21.21.11.70.9
Delay disc. indifference point, 8s delay1.21.42.01.31.3-1.3-1.31.31.21.4-1.01.11.11.11.3-0.3
Indifference point function ln k3.66.37.12.72.7-2.7-2.72.72.72.5-2.62.62.52.52.50.5
Indifference point function log k3.66.37.12.72.7-2.7-2.72.72.72.5-2.62.62.52.52.50.5
Patch foraging total patch changes 0 sec4.68.611.6-2.8-2.82.82.9-2.9-3.0-3.43.2-3.0-3.2-3.2-2.9-1.6
Patch foraging total patch changes 12 sec5.87.59.5-2.7-2.72.72.8-2.8-2.8-2.73.1-2.9-2.9-2.9-2.7-1.5
Patch foraging total patch changes 18 sec5.68.611.7-3.0-3.03.03.0-3.1-3.1-3.43.1-3.1-2.9-2.9-2.8-0.8
Patch foraging total patch changes 24 sec3.25.56.7-2.4-2.42.42.4-2.4-2.5-2.42.6-2.4-2.5-2.5-2.3-0.8
Patch foraging total patch changes 6 sec6.39.611.4-3.0-3.03.03.1-3.1-3.2-3.43.3-3.3-3.3-3.3-3.1-1.8
Patch foraging time to switch 0 sec1.93.84.5-2.1-2.12.12.1-2.1-2.1-2.02.0-2.1-1.8-1.8-2.1-0.3
Patch foraging water rate 0 sec2.75.66.52.52.5-2.5-2.52.52.52.4-2.42.52.22.22.50.5
Patch foraging water rate 12 sec2.04.25.32.32.3-2.3-2.32.22.22.2-2.02.11.91.91.9-0.3
Patch foraging water rate 18 sec0.40.60.90.80.8-0.8-0.80.80.80.9-0.71.00.60.60.90.2
Patch foraging water rate 24 sec4.56.37.12.62.6-2.6-2.72.72.72.4-2.62.62.62.62.40.6
Patch foraging water rate 6 sec5.78.310.13.03.0-3.0-3.03.03.03.2-2.93.02.92.93.00.9
Seeking ratio, delayed vs. immediate footshock0.30.40.70.60.6-0.6-0.60.60.60.5-0.80.80.60.60.30.6
Distance traveled before self-admin2.02.63.9-1.5-1.51.51.5-1.6-1.6-2.01.6-1.7-1.8-1.9-1.3-1.3
Distance traveled after self-admin1.11.42.3-1.0-1.01.01.1-1.1-1.1-1.51.1-1.2-1.2-1.4-1.2-1.1
Extensor digitorum longus weight4.618.020.84.44.4-4.4-4.44.44.44.5-4.44.14.54.64.20.8
Bone: elastic displacement5.56.47.7-2.5-2.62.62.6-2.6-2.6-2.52.6-2.8-2.5-2.6-2.7-1.1
Bone: elastic work0.10.10.70.10.1-0.1-0.00.0-0.0-0.00.1-0.3-0.1-0.1-0.2-0.9
Bone: endosteal estimation6.915.118.64.34.3-4.3-4.24.24.24.1-3.83.93.73.73.7-0.5
Bone: endosteal perimeter6.313.316.04.04.0-4.0-4.03.93.93.9-3.63.73.53.53.6-0.0
Epididymis fat weight0.31.11.71.31.3-1.3-1.21.21.11.1-0.80.70.90.80.3-1.3
Delta time in closed arm before/after self-admin0.00.00.3-0.0-0.00.00.0-0.00.00.1-0.00.1-0.1-0.1-0.10.6
Delta time in open arm before/after self-admin1.01.01.5-1.1-1.11.11.1-1.1-1.1-1.21.0-1.1-1.0-0.9-0.8-0.3
Diff in mean of infusions in LGA sessions0.70.91.51.11.0-1.0-1.01.00.91.2-0.60.90.80.81.0-0.6
Delay discount exponential model param1.01.22.8-1.0-1.01.01.0-1.0-1.0-1.41.0-1.1-1.0-0.9-1.7-0.4
Extinction: sum of active levers before priming1.92.12.71.61.6-1.6-1.61.61.61.4-1.51.61.41.30.80.0
Active lever presses in extinction session 60.30.31.60.60.6-0.6-0.50.50.40.4-0.20.20.30.30.1-1.3
Bone: final force11.017.520.64.54.5-4.5-4.54.54.44.3-4.24.24.24.24.2-0.0
Bone: final moment12.319.723.14.84.8-4.8-4.84.84.74.5-4.44.44.44.44.50.0
Food consumed during 24 hour testing period1.31.82.41.51.5-1.5-1.51.51.50.9-1.11.61.31.31.4-0.1
Glucose0.40.73.2-0.3-0.40.40.5-0.5-0.6-0.60.9-0.9-0.9-1.1-0.7-1.8
Heart weight0.10.20.30.40.5-0.4-0.50.50.50.6-0.40.50.40.40.30.2
Delay discount hyperbolic model param1.01.12.7-1.0-1.01.01.0-1.0-1.0-1.31.0-1.1-0.9-0.9-1.6-0.3
Intermittent access intake day 1-15 change0.10.21.00.00.1-0.1-0.10.10.20.6-0.40.20.60.50.11.0
Intermittent access intake escalation0.30.51.50.40.4-0.4-0.50.50.61.0-0.80.61.01.00.41.2
Intermittent access intake escalation 20.10.11.1-0.1-0.10.10.00.00.10.4-0.30.20.50.4-0.11.1
Intermitt. access day 1 inactive lever presses0.10.20.8-0.5-0.50.50.5-0.4-0.4-0.40.2-0.2-0.3-0.30.10.9
Intermitt. access day 15 inactive lever presses0.20.44.3-0.5-0.40.40.3-0.3-0.20.1-0.20.30.00.1-0.12.1
Intermitt. access escalation Index0.10.21.10.50.5-0.5-0.40.40.30.1-0.10.20.0-0.00.1-1.1
Intermittent access day 1 total infusions1.01.62.3-1.3-1.41.31.3-1.4-1.4-1.51.4-1.0-1.3-1.4-0.6-0.2
Intermittent access day 15 total infusions0.50.71.1-1.1-1.01.01.0-1.0-0.9-0.70.8-0.6-0.5-0.6-0.50.6
Intermittent access terminal intake (last 3 days)0.70.91.6-1.2-1.21.21.2-1.1-1.1-0.80.9-0.7-0.7-0.7-0.60.7
Intermittent access total infusions1.31.62.3-1.5-1.51.51.5-1.4-1.4-1.21.2-1.0-1.1-1.1-0.80.5
Intermittent access day 1 locomotion0.60.81.2-0.8-0.80.80.8-0.9-0.9-1.11.1-0.9-1.0-1.1-0.1-1.1
Intermittent access day 15 total locomotion0.30.50.7-0.7-0.70.70.7-0.7-0.8-0.80.8-0.6-0.8-0.80.1-0.3
Intermittent access total locomotion2.02.43.2-1.6-1.61.61.6-1.6-1.7-1.81.7-1.5-1.7-1.7-0.8-0.5
Intermittent access standard deviation0.10.20.3-0.5-0.50.50.5-0.4-0.4-0.00.2-0.3-0.1-0.1-0.40.6
Left kidney weight1.35.97.92.42.4-2.4-2.52.52.52.8-2.52.72.62.52.01.2
Right kidney weight4.018.223.34.64.6-4.6-4.64.64.64.8-4.34.34.34.33.70.3
Cocaine induced anxiety2.02.93.61.91.9-1.9-1.91.81.81.7-1.61.61.81.81.3-0.3
Post-drug Anxiety3.33.54.22.02.0-2.0-2.02.02.01.9-2.01.92.02.01.30.1
Baseline Anxiety0.20.20.40.40.5-0.5-0.50.50.50.4-0.60.70.40.40.30.6
Tail length0.00.00.1-0.0-0.00.00.0-0.0-0.0-0.30.10.1-0.1-0.2-0.10.0
Length with tail1.45.97.32.72.7-2.7-2.72.72.62.4-2.52.52.42.42.2-0.0
Length without tail5.317.020.24.54.5-4.5-4.54.44.44.2-4.24.14.14.14.0-0.0
Times rat made contact with spout0.00.00.3-0.2-0.20.20.2-0.2-0.2-0.50.2-0.10.00.0-0.00.3
Lifetime Intake2.12.53.6-1.9-1.91.91.8-1.8-1.8-1.61.6-1.4-1.5-1.4-0.90.4
Liver weight, left9.315.418.14.34.2-4.2-4.24.24.24.0-4.04.13.83.73.90.3
Liver weight, right2.95.16.02.42.4-2.4-2.42.42.42.2-2.32.42.42.31.80.4
Locomotor activity1.32.13.0-1.5-1.51.51.5-1.5-1.5-1.61.5-1.4-1.3-1.3-1.70.1
Locomotor testing distance3.15.56.5-2.5-2.52.52.5-2.5-2.5-2.52.4-2.3-2.3-2.3-2.60.0
Locomotor testing rearing1.83.64.5-2.1-2.12.12.0-2.0-2.0-2.11.9-1.8-1.7-1.7-2.10.3
Locomotion in novel chamber3.95.06.12.12.1-2.1-2.22.22.32.2-2.42.42.52.52.41.8
Locomotion in novel chamber post-restriction0.20.31.30.30.3-0.3-0.30.40.40.3-0.50.60.50.50.41.2
Fecal boli incidents, locomotor time 10.91.31.9-1.3-1.31.31.3-1.2-1.2-1.01.0-0.9-1.4-1.4-0.60.5
Change in fecal boli incidents, locomotor task0.20.20.70.60.6-0.6-0.50.50.50.3-0.20.20.50.40.2-0.9
Time >=10cm from walls, locomotor time 10.50.52.0-0.3-0.40.40.4-0.5-0.5-0.40.8-0.8-0.9-0.8-0.6-1.4
Bouts of movement, locomotor time 10.00.00.1-0.0-0.00.00.0-0.0-0.00.20.1-0.00.00.2-0.3-0.2
Total resting periods, locomotor time 10.40.41.0-0.6-0.60.60.6-0.7-0.7-0.40.8-0.7-0.6-0.5-1.0-0.4
Rest time, locomotor task time 10.70.91.6-0.9-0.90.90.9-0.9-0.9-0.91.0-0.9-0.9-0.9-1.3-0.4
Distance moved, locomotor task time 10.00.00.10.00.0-0.0-0.00.0-0.0-0.1-0.0-0.0-0.1-0.00.3-0.4
Vertical activity count, locomotor time 10.41.11.31.11.1-1.1-1.11.11.11.0-1.11.01.01.01.1-0.4
Time >=10cm from walls, locomotor time 20.40.50.7-0.9-0.80.80.8-0.8-0.8-0.50.7-0.7-0.8-0.7-0.70.3
Bouts of movement, locomotor time 22.43.84.42.12.1-2.1-2.12.12.11.7-2.02.11.82.02.00.6
Total resting periods, locomotor time 22.44.14.92.22.2-2.2-2.22.22.21.7-2.12.21.92.02.00.6
Rest time, locomotor task time 20.20.30.9-0.3-0.40.40.4-0.4-0.4-0.80.4-0.5-0.5-0.6-0.9-0.7
Distance moved, locomotor task time 20.00.00.1-0.2-0.20.20.2-0.2-0.20.20.2-0.2-0.1-0.00.1-0.2
Vertical activity count, locomotor time 20.10.20.30.30.3-0.3-0.30.30.30.5-0.40.40.50.50.60.4
Light reinforcement 11.02.53.5-1.9-1.81.81.7-1.7-1.6-1.81.3-1.2-1.4-1.4-1.31.5
Light reinforcement 20.20.33.1-0.5-0.40.40.3-0.3-0.2-0.3-0.10.2-0.1-0.10.41.8
Bone: marrow area6.514.217.74.24.2-4.2-4.14.14.04.0-3.73.73.63.53.6-0.6
Bone: maximum diameter1.83.44.72.22.1-2.1-2.12.01.92.1-1.61.61.61.61.6-1.1
Bone: maximum force14.425.631.25.65.6-5.5-5.55.55.45.2-4.94.95.05.05.0-0.6
Bone: maximum moment16.028.134.05.85.8-5.8-5.85.75.65.4-5.25.25.25.25.2-0.5
Mean time between licks in bursts0.00.10.1-0.3-0.30.30.3-0.3-0.3-0.30.2-0.4-0.2-0.2-0.40.0
Mean num. licks in bursts0.40.61.00.60.6-0.6-0.60.60.70.9-0.90.61.01.01.00.8
Cd content in liver0.30.40.5-0.7-0.70.70.6-0.6-0.6-0.70.5-0.4-0.6-0.6-0.60.4
Co content in liver0.30.40.5-0.7-0.70.70.7-0.7-0.6-0.60.7-0.6-0.5-0.5-0.40.2
Cu content in liver0.30.41.90.80.7-0.7-0.60.60.5-0.0-0.20.40.30.30.1-1.4
Fe content in liver1.62.02.5-1.6-1.61.61.5-1.5-1.5-1.41.4-1.5-1.3-1.3-1.30.2
K content in liver0.20.10.4-0.3-0.30.30.3-0.3-0.3-0.10.5-0.4-0.2-0.2-0.6-0.6
Mg content in liver0.20.20.7-0.4-0.40.40.4-0.4-0.4-0.80.5-0.3-0.3-0.3-0.50.1
Mn content in liver0.00.00.1-0.1-0.10.10.1-0.1-0.1-0.10.3-0.1-0.1-0.1-0.3-0.4
Na content in liver0.00.00.1-0.1-0.10.10.1-0.1-0.00.00.00.00.10.2-0.00.3
Rb content in liver1.41.73.4-0.9-1.01.01.0-1.1-1.2-1.71.4-1.3-1.4-1.4-1.4-1.9
Se content in liver3.54.14.9-2.0-2.02.02.1-2.1-2.1-2.12.2-2.2-2.1-2.1-2.2-0.9
Sr content in liver0.60.60.80.90.9-0.9-0.90.80.80.0-0.60.70.70.70.7-0.5
Zn content in liver0.91.02.0-1.1-1.11.11.1-1.0-1.0-1.41.0-0.9-0.9-0.9-1.10.2
Bone: minimum diameter7.914.518.04.24.2-4.2-4.24.14.13.8-3.83.83.63.53.7-0.4
Time in familiar zone, hab. session 10.10.10.5-0.1-0.10.10.1-0.1-0.0-0.2-0.20.10.20.10.20.7
Time in novel zone, hab. session 10.10.10.30.30.2-0.2-0.20.20.20.1-0.00.2-0.1-0.10.0-0.5
Total zone transitions, hab. session 10.10.10.3-0.4-0.40.40.4-0.4-0.3-0.20.2-0.2-0.2-0.3-0.20.5
Total locomotion distance, hab. session 10.30.41.5-0.3-0.30.40.4-0.4-0.5-0.50.7-0.6-0.6-0.7-0.7-1.2
Locomotion velocity, hab. session 10.20.21.2-0.2-0.20.20.2-0.3-0.3-0.40.6-0.5-0.5-0.5-0.5-1.1
Time in familiar zone, hab. session 21.41.51.91.11.1-1.1-1.21.21.21.1-1.31.31.41.41.30.9
Time in novel zone, hab. session 21.61.62.3-1.0-1.11.11.1-1.2-1.2-1.31.4-1.3-1.5-1.5-1.4-1.3
Total zone transitions, hab. session 20.20.20.3-0.6-0.60.60.6-0.5-0.5-0.50.5-0.5-0.3-0.4-0.50.1
Total locomotion distance, hab. session 20.30.40.6-0.5-0.50.50.6-0.6-0.6-0.70.8-0.7-0.6-0.5-0.7-0.7
Locomotion velocity, hab. session 20.20.20.4-0.3-0.40.40.4-0.4-0.4-0.50.6-0.5-0.4-0.3-0.5-0.6
Novel to familiar place preference ratio1.21.31.91.41.3-1.3-1.31.31.30.8-1.11.20.90.81.2-0.3
Novelty place preference0.70.81.21.11.1-1.1-1.11.01.00.5-0.81.00.50.50.9-0.5
Time in novel zone, NPP test0.50.50.90.90.9-0.9-0.90.90.80.3-0.70.80.40.30.7-0.6
Total zone transitions, NPP test2.43.44.0-1.8-1.81.81.8-1.9-1.9-2.02.0-2.0-2.0-1.9-2.0-1.0
Total locomotion distance, NPP test3.24.35.2-2.0-2.02.02.1-2.1-2.1-2.22.3-2.2-2.3-2.2-2.2-1.2
Locomotion velocity, NPP test2.02.93.5-1.6-1.61.61.6-1.7-1.7-1.81.9-1.8-1.9-1.8-1.8-1.2
Intraocular pressure5.88.310.9-3.2-3.23.23.1-3.1-3.0-3.32.7-2.7-2.7-2.7-2.80.7
Delta distance traveled before/after self-admin0.00.00.10.10.1-0.1-0.10.10.10.1-0.20.20.20.2-0.10.3
Delta ambulatory time before/after self-admin0.00.00.3-0.2-0.10.10.1-0.1-0.1-0.00.00.00.10.0-0.50.4
Parametrial fat weight0.51.31.9-1.4-1.41.41.3-1.3-1.2-1.21.0-1.1-0.7-0.7-0.80.8
Pavlov. Cond. lever latency0.20.32.70.10.0-0.00.0-0.1-0.2-0.40.4-0.4-0.5-0.4-0.3-1.6
Pavlov. Cond. magazine entry latency0.91.13.60.60.7-0.7-0.80.80.91.2-1.11.31.11.11.01.9
Pavlov. Cond. change in total contacts1.21.33.70.70.7-0.7-0.80.91.01.3-1.21.21.21.21.21.9
Pavlov. Cond. index score0.70.93.10.50.6-0.6-0.70.70.81.1-1.01.11.11.00.91.8
Pavlov. Cond. latency score0.60.83.10.40.5-0.5-0.50.60.71.0-0.91.01.00.90.81.7
Pavlov. Cond. lever contacts0.30.43.8-0.3-0.20.20.1-0.10.10.4-0.40.40.50.30.31.9
Pavlov. Cond. magazine entry number0.40.51.8-0.4-0.40.40.5-0.5-0.6-0.90.7-0.9-0.7-0.7-0.7-1.3
Pavlov. Cond. intertrial magazine entries4.04.87.5-1.7-1.81.81.9-2.0-2.1-2.12.5-2.5-2.3-2.3-2.4-2.7
Pavlov. Cond. lever-magazine prob. diff.1.01.22.80.80.8-0.8-0.90.91.01.4-1.21.31.21.21.11.7
Pavlov. Cond. response bias0.30.42.40.10.2-0.2-0.20.30.30.7-0.60.70.50.40.51.5
Pavlov. Cond. lever latency0.81.11.60.90.9-0.9-1.01.01.01.1-1.21.30.90.91.11.1
Pavlov. Cond. magazine entry latency0.40.55.00.30.2-0.2-0.10.0-0.1-0.10.5-0.5-0.5-0.5-0.4-2.2
Pavlov. Cond. change in total contacts0.50.81.31.11.1-1.1-1.11.01.00.6-0.70.80.80.80.8-0.9
Pavlov. Cond. index score0.40.54.40.0-0.00.00.1-0.2-0.3-0.40.8-0.7-0.5-0.5-0.6-2.1
Pavlov. Cond. latency score0.40.64.4-0.1-0.10.10.2-0.3-0.4-0.50.8-0.8-0.6-0.6-0.7-2.1
Pavlov. Cond. lever contacts0.60.81.2-0.7-0.70.70.8-0.8-0.9-1.01.1-1.1-0.8-0.8-1.0-1.1
Pavlov. Cond. magazine entry number0.50.66.0-0.7-0.70.60.5-0.5-0.4-0.3-0.10.20.10.10.02.5
Pavlov. Cond. intertrial magazine entries2.74.05.9-2.4-2.42.42.3-2.2-2.1-2.01.7-1.5-1.7-1.7-1.81.7
Pavlov. Cond. lever-magazine prob. diff.0.30.54.60.20.1-0.1-0.0-0.0-0.1-0.30.6-0.6-0.4-0.4-0.5-2.1
Pavlov. Cond. response bias0.30.41.5-0.3-0.30.30.4-0.4-0.5-0.60.7-0.7-0.5-0.5-0.6-1.2
Time in closed arm before self-admin1.52.02.51.61.6-1.6-1.51.51.51.4-1.21.11.51.41.4-0.7
Time in closed arm after self-admin0.30.30.50.50.5-0.5-0.50.50.50.7-0.40.40.70.70.40.5
Time in open arm before self-admin0.30.40.7-0.5-0.50.50.5-0.5-0.6-0.70.6-0.5-0.8-0.8-0.6-0.6
Time in open arm after self-admin0.20.30.7-0.4-0.40.40.4-0.4-0.4-0.70.4-0.5-0.6-0.5-0.6-0.8
Bone: periosteal estimation9.620.325.75.15.0-5.0-5.04.94.84.7-4.44.44.34.24.3-1.0
Bone: periosteal perimeter8.815.218.84.34.3-4.3-4.34.24.24.1-3.83.93.73.73.8-0.5
Bone: post-yield work7.410.913.43.73.6-3.6-3.63.53.53.6-3.13.13.23.33.1-0.7
Progressive ratio test 1 active lever presses6.68.19.8-3.1-3.13.13.1-3.1-3.1-3.03.0-2.8-2.8-2.9-2.4-0.3
Progressive ratio test 1 breakpoint6.47.89.3-3.1-3.03.03.0-3.0-3.0-2.92.9-2.7-2.7-2.9-2.3-0.3
Progressive ratio test 1 inactive lever presses0.60.92.2-1.2-1.21.21.1-1.1-1.0-0.90.6-0.6-0.5-0.5-0.31.5
Progressive ratio test 2 active lever presses1.51.72.6-1.6-1.61.61.5-1.5-1.5-1.21.4-1.2-1.1-1.2-0.80.3
Progressive ratio test 2 breakpoint1.41.62.4-1.5-1.51.51.5-1.5-1.4-1.21.3-1.1-1.0-1.1-0.70.3
Progressive ratio test 2 inactive lever presses0.50.81.3-1.2-1.11.11.1-1.0-1.0-0.70.7-0.6-0.6-0.8-0.71.0
Incentive Sensitization - Responses0.50.71.20.60.7-0.7-0.70.70.80.8-0.80.91.11.01.00.6
Incentive Sensitization - Breakpoint0.40.50.90.50.6-0.6-0.60.60.70.7-0.70.81.00.90.90.6
Sum of active levers in priming session hrs 5-60.10.10.6-0.1-0.10.10.1-0.2-0.2-0.30.3-0.3-0.3-0.4-0.6-0.8
Progressive ratio1.11.72.1-1.2-1.21.21.3-1.3-1.3-1.41.5-1.4-1.3-1.3-1.4-1.1
Food seeking constrained by brief footshock2.63.14.2-1.7-1.71.71.8-1.8-1.8-1.81.8-2.0-1.9-1.9-1.8-1.3
Seeking ratio, punishment vs. effort0.00.00.10.10.1-0.1-0.20.20.20.2-0.30.20.10.10.20.4
Retroperitoneal fat weight0.73.04.5-1.7-1.71.71.7-1.8-1.8-1.31.9-1.9-1.7-1.8-2.1-1.0
Reaction time number correct0.91.72.21.51.4-1.4-1.41.41.41.3-1.21.21.31.31.2-0.2
Reaction time mean minus median3.28.110.3-3.2-3.23.23.1-3.1-3.0-2.92.7-2.7-2.8-2.8-2.50.8
Reaction time mean minus median AUC2.25.77.2-2.7-2.72.72.6-2.6-2.5-2.52.3-2.3-2.4-2.4-2.10.6
Reaction time num false alarms1.42.03.6-1.5-1.51.51.5-1.5-1.4-1.91.3-1.2-1.4-1.4-1.50.2
Reaction time num false alarms AUC1.62.54.1-1.7-1.71.71.6-1.6-1.6-2.01.5-1.3-1.5-1.6-1.60.4
Reaction time trials correct on left0.91.72.21.51.4-1.4-1.41.41.41.3-1.21.21.31.31.2-0.2
Reaction time trials on left0.71.31.71.31.3-1.3-1.21.21.21.1-1.11.11.21.21.0-0.2
Reaction time mean0.71.11.5-1.1-1.11.11.1-1.1-1.1-1.10.9-0.9-1.2-1.2-1.0-0.0
Reaction time mean AUC0.40.71.0-0.8-0.80.80.8-0.8-0.8-1.00.7-0.7-1.0-1.0-0.8-0.1
Median of all reaction times0.00.00.2-0.1-0.10.10.1-0.1-0.1-0.20.1-0.1-0.4-0.4-0.3-0.3
Reaction time omissions7.911.514.2-3.8-3.73.73.7-3.7-3.6-3.33.3-3.3-3.3-3.3-3.40.4
Reaction time false alarm rate2.02.74.1-1.8-1.81.81.8-1.7-1.7-2.01.5-1.4-1.7-1.7-1.70.5
Reaction time premature initiation rate3.75.17.0-2.6-2.62.62.5-2.5-2.4-2.02.1-2.2-1.8-1.8-2.41.2
Reaction time premature initiations1.12.02.9-1.7-1.71.71.6-1.6-1.5-1.11.3-1.4-1.0-1.0-1.61.1
Std. dev. reaction times4.07.48.9-3.0-3.03.02.9-2.9-2.9-2.92.6-2.6-2.8-2.8-2.60.4
Reaction time trials completed0.71.31.71.31.3-1.3-1.21.21.21.1-1.11.11.21.21.0-0.2
Reaction time trials AUC1.22.22.81.71.7-1.7-1.61.61.61.5-1.41.41.51.51.4-0.2
Run reversals in cocaine runway, females0.60.61.00.60.6-0.6-0.60.70.70.7-0.90.81.01.00.80.9
Run reversals in cocaine runway, males0.60.60.9-1.0-0.90.90.9-0.9-0.8-0.80.6-0.7-0.7-0.7-0.50.7
Latency to leave start box in cocaine runway0.00.00.1-0.1-0.00.00.0-0.0-0.00.20.20.20.00.0-0.10.3
Latency to leave start box in cocaine runway, F0.80.91.3-1.1-1.11.11.1-1.1-1.0-0.71.1-0.8-0.9-0.9-0.80.2
Latency to leave start box in cocaine runway, M1.71.61.91.41.4-1.4-1.41.41.41.3-1.21.41.31.31.00.1
Std. dev. time between licks in bursts1.21.62.0-1.3-1.31.31.3-1.3-1.3-1.41.2-1.2-1.3-1.3-1.3-0.0
Total sessions with >9 infusions2.22.73.7-1.9-1.91.91.9-1.9-1.8-1.61.6-1.5-1.5-1.6-0.90.4
Short access day 1 total inactive lever presses1.41.92.7-1.6-1.61.61.6-1.6-1.5-1.51.3-1.3-1.2-1.3-0.80.4
Short access day 10 total inactive lever presses0.00.10.90.10.1-0.1-0.20.20.2-0.2-0.40.40.10.20.01.0
Short access day 1 total infusions1.01.41.8-1.3-1.31.31.3-1.3-1.3-1.31.3-1.1-1.1-1.1-0.6-0.2
Short access day 10 total infusions1.72.22.9-1.7-1.71.71.6-1.6-1.6-1.61.5-1.3-1.5-1.5-0.60.4
Short access total infusions3.14.05.1-2.3-2.32.32.2-2.2-2.2-2.22.1-1.9-2.0-2.0-1.2-0.0
Short access day 1 locomotion0.40.40.7-0.7-0.70.70.7-0.7-0.7-0.90.7-0.6-0.6-0.60.6-0.0
Short access day 10 total locomotion0.20.40.5-0.6-0.60.60.6-0.6-0.6-0.70.7-0.6-0.6-0.7-0.0-0.1
Short access total locomotion0.91.11.7-1.2-1.11.11.1-1.1-1.1-1.31.0-1.0-1.0-1.1-0.10.2
One hour access (0.3 mA shock)0.30.42.40.00.1-0.1-0.10.20.30.7-0.50.60.60.70.81.6
Compulsive drug intake0.30.40.90.40.4-0.4-0.40.50.50.8-0.60.50.60.80.71.0
One hour access (shock baseline)0.20.21.00.20.2-0.2-0.20.30.30.5-0.40.60.60.60.61.0
Social response proportion0.20.20.3-0.5-0.50.50.5-0.5-0.5-0.60.3-0.3-0.4-0.4-0.4-0.0
Social responses5.57.19.0-3.0-3.03.02.9-2.9-2.8-2.92.4-2.3-2.5-2.5-2.80.8
Social time0.30.40.70.60.6-0.6-0.60.60.70.8-0.70.80.80.80.20.7
Soleus weight0.92.63.61.61.6-1.6-1.61.61.61.9-1.71.51.71.71.70.6
Bone: stiffness18.930.735.56.05.9-5.9-5.95.95.95.6-5.55.65.65.75.60.3
Tibialis anterior weight2.68.711.72.62.7-2.7-2.82.82.93.1-3.23.03.43.43.12.4
Time to tail flick, vehicle, before self-admin1.41.54.3-1.3-1.31.31.2-1.2-1.2-1.11.1-1.2-0.9-0.9-2.10.2
Time to tail flick, vehicle, after self-admin0.30.40.90.50.5-0.5-0.50.50.60.9-0.70.40.90.90.70.3
Time to tail flick, test, before self-admin0.20.20.6-0.4-0.40.40.4-0.4-0.4-0.40.3-0.4-0.3-0.2-0.8-0.4
Time to tail flick, test, after self-admin1.11.21.71.11.1-1.1-1.11.11.11.0-1.21.01.21.31.00.6
Delta time to tail flick, vehicle, before/after SA0.70.71.90.80.8-0.8-0.80.80.81.0-0.80.70.90.81.40.1
Delta time to tail flick, test, before/after SA0.60.61.10.70.7-0.7-0.70.70.70.6-0.80.70.70.71.01.0
Tibia length4.612.717.24.14.1-4.1-4.04.03.83.3-3.43.43.33.33.2-1.3
Ambulatory time before self-admin2.23.34.6-1.8-1.91.91.9-1.9-1.9-2.21.8-1.9-2.0-2.0-1.4-0.8
Ambulatory time after self-admin1.82.13.2-1.5-1.51.51.5-1.5-1.5-1.81.4-1.5-1.5-1.6-1.5-0.3
Bone: tissue strength1.51.61.91.41.4-1.4-1.41.31.31.2-1.21.21.21.21.3-0.2
Total heroin consumption0.50.60.90.90.9-0.9-0.90.90.80.7-0.70.70.70.50.6-0.7
Bone: trabecular number3.96.48.73.02.9-2.9-2.82.82.72.3-2.42.32.32.42.4-1.1
Bone: trabecular spacing1.41.82.5-1.6-1.51.51.5-1.5-1.4-1.21.1-1.1-1.3-1.5-1.21.1
Bone: trabecular thickness0.40.52.20.30.3-0.3-0.40.40.50.4-0.70.70.91.00.81.5
Bone: trabecular tissue density0.71.03.10.70.7-0.7-0.80.80.90.5-1.21.21.01.01.31.7
Water consumed over 24 hours0.00.10.30.20.2-0.2-0.10.10.1-0.40.20.10.20.20.1-0.5
Number of responses in last shaping day0.10.10.9-0.1-0.10.10.0-0.00.0-0.3-0.20.20.30.10.81.0