Hub : Genes

Smarcc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Smarcc2 0.08 0.06 6.3e-05 0.1 0.09 0.09 0.09 7.3e-06 2.3e-05 1.0e-05 1.1e-05
2 PL isoform ratio XM_006240806.4 0.05 0.04 4.6e-06 0.04 0.05 0.04 0.04 5.3e-05 7.0e-06 1.0e-05 1.8e-05
3 Liver gene expression Smarcc2 0.09 0.06 1.7e-09 0.05 0.06 0.06 0.06 2.2e-06 2.7e-07 2.7e-07 5.7e-07
4 Brain intron excision ratio chr7_902231_902576 0.04 0.03 1.7e-03 0.01 0.01 0.01 0.01 5.1e-02 4.4e-02 3.6e-02 7.1e-02
5 Brain isoform ratio XM_006240806.4 0.05 0.04 5.3e-04 0.02 0.02 0.02 0.02 1.0e-02 9.3e-03 2.6e-03 1.2e-02
6 PL intron excision ratio chr7_902231_902576 0.05 0.04 1.6e-05 0.04 0.04 0.04 0.04 3.5e-05 2.7e-05 5.5e-05 8.2e-05
7 Adipose gene expression Smarcc2 0.04 0.03 2.5e-04 0.03 0.03 0.03 0.03 2.5e-04 2.1e-04 3.0e-04 4.1e-04
8 Brain isoform ratio XM_001055738.7 0.03 0.03 8.5e-03 0.02 0.01 0.02 0.01 6.9e-03 1.5e-02 1.1e-02 1.5e-02
9 NAcc isoform ratio XM_001055673.7 0.09 0.07 5.2e-05 0.03 0.02 0.03 0.02 1.3e-04 7.3e-04 6.6e-04 7.3e-04
10 NAcc isoform ratio XM_001055738.7 0.07 0.05 3.0e-05 0.03 0.03 0.02 0.03 2.5e-04 2.8e-04 9.0e-04 2.8e-04
11 Eye isoform ratio XM_006240806.4 0.28 0.17 4.1e-03 0.18 0.13 0.1 0.16 8.6e-04 4.6e-03 1.1e-02 1.9e-03
12 NAcc intron excision ratio chr7_901474_902555 0.03 0.03 6.7e-03 0 0.01 0.01 0.01 1.0e-01 6.5e-02 3.7e-02 5.6e-02
13 RMTg alternative TSS XM_006240805.4 0.18 0.12 5.0e-03 -0 -0.01 -0.01 -0.01 4.6e-01 8.4e-01 6.2e-01 7.8e-01
14 RMTg alternative TSS XM_039080000.1 0.19 0.12 2.8e-03 -0 -0.01 -0.01 -0.01 4.5e-01 6.5e-01 7.8e-01 5.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.91.66.6-1.00.10.20.50.10.2-0.4-0.90.9-0.9-0.8-2.0-2.62.6
Area under the delay curve0.10.10.4-0.20.30.00.0-0.00.3-0.3-0.60.2-0.2-0.6-0.5-0.40.4
BMI with tail7.022.628.35.15.35.3-5.2-5.35.3-5.3-5.25.2-5.2-5.1-3.90.7-0.7
BMI without tail1.22.63.82.01.91.8-1.9-1.91.8-1.8-1.71.5-1.5-1.6-0.90.7-0.7
Body weight1.24.87.12.22.62.4-2.4-2.42.6-2.5-2.72.1-2.1-2.6-1.60.4-0.4
Weight adjusted by age0.10.10.50.4-0.00.0-0.2-0.1-0.10.10.3-0.10.10.30.50.7-0.7
Bone surface1.73.114.6-1.9-0.4-0.01.10.5-0.2-0.1-0.50.8-0.8-0.5-2.6-3.83.8
Bone volume1.93.214.3-1.6-0.10.20.90.20.1-0.3-0.91.1-1.1-0.8-2.8-3.83.8
Breakpoint value in progressive ratio session2.22.44.1-1.3-1.7-1.61.41.6-1.71.72.0-1.81.81.91.70.2-0.2
Number of licking bursts2.83.35.52.32.12.0-2.2-2.12.0-1.9-1.81.6-1.6-2.0-0.71.3-1.3
Context. condit. distance diff. score0.20.20.30.50.50.6-0.6-0.60.5-0.5-0.40.5-0.5-0.4-0.20.2-0.2
Locomotion velocity, session 10.50.62.0-0.40.40.30.1-0.10.5-0.5-0.90.5-0.5-0.9-1.1-1.41.4
Locomotion distance, session 10.60.73.4-1.1-0.3-0.30.70.5-0.20.1-0.1-0.00.0-0.2-1.0-1.81.8
Locomotion velocity, session 21.31.54.4-1.8-1.1-1.01.51.1-1.00.90.8-0.60.60.7-0.5-2.12.1
Locomotion distance, session 22.33.26.8-2.6-1.8-1.92.32.0-1.71.61.0-1.51.51.00.2-2.12.1
Locomotion velocity, session 34.55.27.1-2.4-2.5-2.52.52.5-2.52.52.4-2.72.72.32.0-0.20.2
Locomotion distance, session 30.10.10.3-0.3-0.3-0.30.30.3-0.30.30.2-0.60.60.20.50.2-0.2
Stereotopy head waving bouts, day 35.05.87.8-2.7-2.8-2.72.82.7-2.82.72.6-2.42.42.61.6-1.01.0
Stereotopy head waving duration, day 33.33.95.8-2.1-2.4-2.12.12.1-2.32.22.4-1.91.92.41.2-0.80.8
Locomotion velocity, session 70.10.10.4-0.4-0.3-0.20.30.2-0.20.20.3-0.00.00.2-0.2-0.60.6
Locomotion distance, session 70.20.20.80.60.20.3-0.4-0.30.2-0.10.00.1-0.10.00.40.9-0.9
Stereotopy head waving bouts, day 70.80.92.0-1.4-0.9-1.01.21.1-0.80.70.5-0.70.70.4-0.2-1.41.4
Stereotopy head waving duration, day 70.80.92.7-1.5-0.7-0.91.21.0-0.70.60.2-0.50.50.2-0.4-1.71.7
Locomotion velocity, session 81.41.64.1-2.0-1.0-1.21.61.3-0.90.90.3-0.90.90.3-0.3-2.02.0
Locomotion distance, session 80.30.41.0-1.0-0.6-0.70.90.7-0.60.60.3-0.70.70.30.2-0.70.7
Degree of sensitization distance0.50.50.90.80.80.8-0.8-0.80.8-0.8-0.70.9-0.9-0.7-0.70.0-0.0
Degree of sensitization stereotypy0.30.41.0-0.20.40.20.0-0.10.5-0.5-0.80.4-0.4-0.8-0.9-1.01.0
Conditioned locomotion1.01.12.41.51.10.9-1.3-1.01.0-0.9-0.70.6-0.6-0.80.31.6-1.6
Cocaine response after cond. corrected2.12.45.32.31.61.6-2.0-1.71.5-1.4-1.21.4-1.4-1.3-0.21.5-1.5
Cocaine response after cond. not corrected2.22.45.62.41.61.6-2.0-1.71.5-1.4-1.11.4-1.4-1.1-0.11.7-1.7
Cocaine response before conditioning0.50.60.9-1.0-0.8-0.80.90.8-0.80.80.8-0.70.70.90.2-0.40.4
Saline control response0.30.40.70.80.80.7-0.8-0.70.8-0.7-0.80.5-0.5-0.8-0.20.4-0.4
Bone: connectivity density0.50.83.7-0.80.00.10.40.10.1-0.2-0.60.6-0.6-0.4-1.5-1.91.9
Bone: cortical apparent density1.31.82.61.51.41.5-1.5-1.51.4-1.4-1.31.6-1.6-1.2-1.10.2-0.2
Bone: cortical area1.42.14.90.51.21.4-0.9-1.21.2-1.4-1.31.8-1.8-1.4-2.2-1.51.5
Bone: cortical porosity0.10.10.5-0.4-0.20.10.20.0-0.10.10.20.1-0.10.2-0.5-0.70.7
Bone: cortical porosity0.30.31.2-0.20.20.5-0.1-0.40.3-0.4-0.40.6-0.6-0.3-1.1-1.01.0
Bone: cortical thickness1.52.43.71.21.61.8-1.4-1.61.6-1.7-1.51.9-1.9-1.6-1.9-0.60.6
Bone: cortical thickness0.60.71.11.01.01.0-1.1-1.11.0-1.0-0.80.6-0.6-0.9-0.30.7-0.7
Bone: cortical tissue density1.01.31.81.31.21.3-1.3-1.31.2-1.2-1.11.4-1.4-1.0-0.80.2-0.2
Condit. Reinf. active minus inactive responses1.82.02.9-1.6-1.6-1.41.51.5-1.61.61.7-1.61.61.51.1-0.40.4
Condit. Reinf. active-inactive response ratio0.40.40.9-0.3-0.7-0.40.40.4-0.70.71.0-0.70.70.90.80.5-0.5
Condit. Reinf. active responses2.53.04.8-2.2-2.0-1.82.11.9-1.91.81.8-1.71.71.70.8-1.31.3
Condit. Reinf. inactive responses1.31.63.0-1.7-1.3-1.31.61.4-1.21.20.9-1.01.00.90.1-1.51.5
Incentive salience index mean1.11.42.6-1.6-1.3-1.21.41.2-1.21.21.1-1.21.20.90.4-1.11.1
Condit. Reinf. lever presses0.70.94.1-1.3-0.3-0.51.00.6-0.20.2-0.3-0.20.2-0.4-0.9-2.02.0
Condit. Reinf. active minus inactive responses2.22.74.7-1.0-1.8-1.61.31.5-1.81.82.2-1.71.72.21.80.9-0.9
Condit. Reinf. active-inactive response ratio1.21.32.90.1-0.8-0.80.30.7-0.91.01.3-1.01.01.31.71.7-1.7
Condit. Reinf. active responses1.31.83.2-1.2-1.6-1.41.31.4-1.61.61.8-1.31.31.81.10.0-0.0
Condit. Reinf. inactive responses0.30.40.8-0.9-0.7-0.50.70.6-0.60.60.5-0.40.40.5-0.1-0.90.9
Condit. Reinf. lever presses2.83.75.5-1.6-2.1-2.01.81.9-2.22.22.2-2.22.22.32.10.6-0.6
Condit. Reinf. lever reinforcers received1.01.52.7-0.9-1.4-1.21.01.2-1.41.41.6-1.21.21.61.20.3-0.3
Conditioned reinforcement - actives0.20.20.6-0.2-0.20.20.1-0.0-0.20.10.30.4-0.40.5-0.6-0.80.8
Conditioned reinforcement - inactives1.01.12.61.60.91.3-1.5-1.40.9-0.9-0.11.0-1.00.0-0.31.2-1.2
Conditioned locomotion2.53.06.9-1.6-2.1-1.61.61.6-2.11.92.5-1.51.52.61.0-0.60.6
Patch foraging indifference point 0 sec3.45.47.62.12.62.7-2.4-2.62.6-2.6-2.42.8-2.8-2.3-2.4-0.20.2
Patch foraging indifference point AUC0.50.60.8-0.7-0.9-0.80.80.8-0.90.90.6-0.90.90.70.90.0-0.0
Delay disc. indifference point, 0s delay2.12.34.70.31.41.1-0.7-1.01.5-1.5-2.11.4-1.4-2.1-2.2-1.61.6
Delay disc. indifference point, 16s delay0.20.20.4-0.5-0.4-0.60.60.6-0.40.40.4-0.50.50.40.1-0.20.2
Delay disc. indifference point, 2s delay0.40.51.10.00.60.5-0.2-0.40.7-0.6-1.00.6-0.6-1.0-0.6-0.80.8
Delay disc. indifference point, 24s delay0.30.30.80.30.70.4-0.4-0.40.7-0.6-0.90.5-0.5-0.9-0.6-0.10.1
Delay disc. indifference point, 4s delay0.40.41.3-1.0-0.5-0.60.80.7-0.40.4-0.0-0.20.20.0-0.3-1.11.1
Delay disc. indifference point, 8s delay0.20.20.50.40.40.1-0.4-0.30.3-0.3-0.50.2-0.2-0.40.10.7-0.7
Indifference point function ln k0.10.20.30.40.40.6-0.5-0.60.4-0.5-0.00.5-0.5-0.0-0.40.1-0.1
Indifference point function log k0.10.20.30.40.40.6-0.5-0.60.4-0.5-0.00.5-0.5-0.0-0.40.1-0.1
Patch foraging total patch changes 0 sec3.15.07.02.12.42.6-2.4-2.62.4-2.5-2.22.6-2.6-2.2-2.2-0.00.0
Patch foraging total patch changes 12 sec1.51.92.91.71.61.6-1.7-1.71.5-1.5-1.41.3-1.3-1.3-0.61.0-1.0
Patch foraging total patch changes 18 sec0.00.00.10.20.20.2-0.2-0.20.2-0.2-0.20.3-0.3-0.2-0.20.1-0.1
Patch foraging total patch changes 24 sec0.50.71.20.60.90.9-0.7-0.80.9-0.9-1.10.9-0.9-1.0-0.9-0.20.2
Patch foraging total patch changes 6 sec1.82.63.51.61.81.9-1.8-1.91.8-1.8-1.61.8-1.8-1.6-1.50.0-0.0
Patch foraging time to switch 0 sec0.30.51.40.30.70.5-0.3-0.40.7-0.7-1.10.7-0.7-1.2-1.0-0.60.6
Patch foraging water rate 0 sec0.40.71.31.10.81.0-1.1-1.10.8-0.7-0.30.6-0.6-0.20.01.0-1.0
Patch foraging water rate 12 sec0.71.02.21.51.01.2-1.4-1.21.0-0.9-0.40.9-0.9-0.4-0.11.1-1.1
Patch foraging water rate 18 sec0.91.24.70.7-0.1-0.1-0.5-0.2-0.20.30.9-0.80.80.91.72.2-2.2
Patch foraging water rate 24 sec1.62.27.42.11.21.1-1.8-1.41.1-0.9-0.30.4-0.4-0.41.02.7-2.7
Patch foraging water rate 6 sec0.91.32.7-0.1-0.9-0.70.30.5-0.91.01.6-1.11.11.61.61.5-1.5
Seeking ratio, delayed vs. immediate footshock1.11.32.1-1.4-1.3-1.11.31.2-1.31.21.3-0.80.81.40.2-1.01.0
Distance traveled before self-admin0.90.91.8-1.3-1.0-1.11.21.1-1.01.00.9-1.01.00.90.7-0.50.5
Distance traveled after self-admin0.20.20.6-0.8-0.5-0.40.60.5-0.50.50.4-0.30.30.50.1-0.40.4
Extensor digitorum longus weight4.819.026.45.14.94.9-5.1-5.04.9-4.8-4.64.3-4.3-4.5-2.52.2-2.2
Bone: elastic displacement0.00.00.10.0-0.1-0.00.10.0-0.00.00.20.3-0.30.1-0.3-0.30.3
Bone: elastic work0.81.01.70.61.00.9-0.7-0.81.0-1.0-1.11.3-1.3-1.2-1.3-0.60.6
Bone: endosteal estimation0.81.63.00.91.21.4-1.1-1.31.2-1.3-1.11.7-1.7-1.2-1.7-0.80.8
Bone: endosteal perimeter0.20.51.7-1.0-0.6-0.40.80.6-0.60.50.50.0-0.00.4-0.7-1.31.3
Epididymis fat weight0.10.20.5-0.2-0.4-0.40.30.4-0.40.50.4-0.60.60.40.70.5-0.5
Delta time in closed arm before/after self-admin1.41.45.11.70.70.9-1.4-1.00.6-0.50.10.3-0.30.11.12.3-2.3
Delta time in open arm before/after self-admin1.41.43.10.71.41.1-0.9-1.01.4-1.3-1.81.0-1.0-1.8-1.2-0.30.3
Diff in mean of infusions in LGA sessions2.12.33.6-1.3-1.7-1.61.51.6-1.71.71.9-1.61.61.91.3-0.00.0
Delay discount exponential model param0.10.10.30.2-0.20.0-0.1-0.1-0.20.20.5-0.20.20.50.40.4-0.4
Extinction: sum of active levers before priming3.43.45.9-1.2-1.8-2.01.51.8-1.92.01.9-2.32.31.92.41.1-1.1
Active lever presses in extinction session 61.11.11.7-1.3-1.1-1.31.31.3-1.11.10.8-1.21.20.70.5-0.50.5
Bone: final force2.94.77.51.42.22.3-1.8-2.12.3-2.4-2.52.6-2.6-2.5-2.7-1.11.1
Bone: final moment2.84.57.31.32.22.2-1.7-2.02.2-2.3-2.52.5-2.5-2.4-2.7-1.11.1
Food consumed during 24 hour testing period0.40.40.70.60.70.7-0.7-0.70.7-0.8-0.80.7-0.7-0.8-0.6-0.00.0
Glucose1.62.53.41.51.91.8-1.7-1.81.9-1.8-1.71.6-1.6-1.7-1.20.3-0.3
Heart weight0.10.10.20.50.00.3-0.4-0.3-0.00.00.20.2-0.20.20.20.5-0.5
Delay discount hyperbolic model param0.20.20.60.1-0.4-0.20.10.1-0.40.40.7-0.40.40.70.50.4-0.4
Intermittent access intake day 1-15 change0.50.52.1-0.2-0.7-0.40.30.3-0.70.71.5-0.50.51.40.50.2-0.2
Intermittent access intake escalation0.80.82.20.4-0.5-0.3-0.10.1-0.60.61.5-0.60.61.41.11.2-1.2
Intermittent access intake escalation 21.11.13.2-0.1-0.9-0.80.40.6-1.01.01.8-1.01.01.71.41.0-1.0
Intermitt. access day 1 inactive lever presses0.60.61.60.5-0.4-0.2-0.3-0.0-0.50.51.2-0.50.51.21.11.3-1.3
Intermitt. access day 15 inactive lever presses1.21.33.1-0.5-1.1-1.00.60.8-1.11.11.7-1.21.21.71.40.8-0.8
Intermitt. access escalation Index0.40.41.8-0.7-0.20.10.40.1-0.20.10.10.3-0.30.2-1.0-1.31.3
Intermittent access day 1 total infusions0.40.40.70.40.60.7-0.6-0.60.7-0.7-0.80.8-0.8-0.7-0.7-0.20.2
Intermittent access day 15 total infusions0.10.20.30.60.30.5-0.6-0.50.2-0.30.20.4-0.40.3-0.10.4-0.4
Intermittent access terminal intake (last 3 days)0.20.30.70.30.30.6-0.4-0.50.3-0.4-0.00.7-0.70.0-0.8-0.40.4
Intermittent access total infusions0.30.40.60.70.60.8-0.8-0.80.6-0.6-0.40.8-0.8-0.3-0.60.1-0.1
Intermittent access day 1 locomotion0.00.00.00.10.00.0-0.1-0.00.0-0.0-0.1-0.00.00.00.10.2-0.2
Intermittent access day 15 total locomotion0.50.62.3-0.3-0.8-0.50.40.5-0.90.81.4-0.60.61.50.60.2-0.2
Intermittent access total locomotion0.20.20.6-0.5-0.6-0.50.50.5-0.60.50.6-0.40.40.70.3-0.20.2
Intermittent access standard deviation0.30.41.6-0.1-0.5-0.20.10.2-0.60.51.3-0.40.41.20.50.4-0.4
Left kidney weight0.30.92.7-0.10.50.5-0.1-0.30.5-0.6-0.80.9-0.9-0.8-1.5-1.61.6
Right kidney weight0.20.60.9-0.9-0.8-0.60.80.7-0.80.70.8-0.50.50.8-0.1-1.01.0
Cocaine induced anxiety1.31.52.9-1.7-1.3-1.41.61.5-1.21.20.8-1.11.10.80.2-1.41.4
Post-drug Anxiety0.80.93.7-1.3-0.4-0.51.00.7-0.40.3-0.2-0.10.1-0.2-0.9-1.91.9
Baseline Anxiety0.00.00.20.20.10.1-0.2-0.10.1-0.00.00.0-0.00.10.20.4-0.4
Tail length4.513.719.2-3.5-4.0-4.13.74.0-4.04.14.0-4.44.44.03.70.3-0.3
Length with tail1.55.57.5-2.7-2.5-2.72.62.7-2.52.52.3-2.72.72.31.9-0.50.5
Length without tail0.20.51.3-0.10.50.5-0.2-0.30.5-0.6-0.80.8-0.8-0.8-1.1-1.01.0
Times rat made contact with spout0.91.01.51.21.11.1-1.2-1.21.1-1.0-1.00.9-0.9-1.0-0.30.9-0.9
Lifetime Intake1.01.12.00.91.01.3-1.1-1.21.0-1.1-0.81.4-1.4-0.7-1.3-0.30.3
Liver weight, left1.32.03.31.81.61.7-1.8-1.81.5-1.5-1.31.4-1.4-1.2-0.80.9-0.9
Liver weight, right0.81.41.91.31.31.3-1.3-1.31.3-1.3-1.01.4-1.4-1.0-1.20.1-0.1
Locomotor activity3.04.89.1-3.0-2.3-2.52.72.5-2.32.21.9-2.42.41.91.1-1.21.2
Locomotor testing distance1.11.93.6-1.9-1.5-1.51.61.5-1.41.41.3-1.51.51.30.6-0.70.7
Locomotor testing rearing0.10.10.3-0.0-0.0-0.1-0.00.1-0.00.10.1-0.40.40.00.40.6-0.6
Locomotion in novel chamber0.20.30.70.70.50.8-0.7-0.70.5-0.5-0.20.7-0.7-0.2-0.30.1-0.1
Locomotion in novel chamber post-restriction3.13.84.8-1.9-2.2-2.12.12.1-2.22.22.1-2.22.22.11.7-0.30.3
Fecal boli incidents, locomotor time 10.70.71.51.20.90.7-1.0-0.80.8-0.7-0.70.6-0.6-0.80.21.2-1.2
Change in fecal boli incidents, locomotor task0.70.72.2-1.2-0.6-0.61.00.7-0.60.50.3-0.40.40.3-0.5-1.51.5
Time >=10cm from walls, locomotor time 10.90.92.10.30.80.8-0.5-0.70.9-0.9-1.11.1-1.1-1.0-1.5-1.01.0
Bouts of movement, locomotor time 10.40.40.7-0.5-0.8-0.70.60.7-0.80.80.8-0.70.70.80.50.2-0.2
Total resting periods, locomotor time 10.91.01.4-1.0-1.2-1.21.11.1-1.21.21.1-1.11.11.10.8-0.10.1
Rest time, locomotor task time 10.40.40.7-0.8-0.7-0.80.80.8-0.70.70.4-0.60.60.40.2-0.50.5
Distance moved, locomotor task time 10.80.92.00.30.90.9-0.6-0.80.9-1.0-0.91.1-1.1-0.9-1.4-1.01.0
Vertical activity count, locomotor time 10.90.91.71.11.11.2-1.3-1.31.1-1.1-0.71.0-1.0-0.7-0.70.4-0.4
Time >=10cm from walls, locomotor time 21.01.11.81.41.11.2-1.3-1.21.1-1.1-0.81.1-1.1-0.9-0.50.7-0.7
Bouts of movement, locomotor time 20.40.41.4-1.0-0.5-0.50.70.6-0.40.40.2-0.30.30.2-0.7-1.21.2
Total resting periods, locomotor time 20.40.51.8-1.0-0.4-0.50.70.5-0.40.30.1-0.20.20.1-0.8-1.31.3
Rest time, locomotor task time 20.20.20.9-0.6-0.1-0.20.50.3-0.10.0-0.20.0-0.0-0.2-0.5-1.01.0
Distance moved, locomotor task time 20.20.20.90.50.10.2-0.4-0.30.1-0.10.2-0.10.10.20.51.0-1.0
Vertical activity count, locomotor time 21.21.32.41.51.21.2-1.5-1.31.1-1.1-0.80.7-0.7-0.8-0.11.5-1.5
Light reinforcement 13.25.98.6-2.7-2.7-2.62.72.6-2.72.72.9-2.52.52.91.6-0.70.7
Light reinforcement 20.91.31.9-1.1-1.2-1.31.31.2-1.21.21.4-1.21.21.40.7-0.20.2
Bone: marrow area0.71.52.70.91.11.3-1.0-1.21.1-1.2-1.01.6-1.6-1.1-1.7-0.80.8
Bone: maximum diameter0.40.83.5-1.1-0.7-0.40.90.6-0.60.40.50.0-0.00.4-0.9-1.91.9
Bone: maximum force3.05.27.71.72.42.4-2.0-2.22.4-2.5-2.62.7-2.7-2.6-2.8-0.90.9
Bone: maximum moment3.05.17.71.62.32.4-1.9-2.22.4-2.5-2.52.7-2.7-2.5-2.8-0.90.9
Mean time between licks in bursts0.91.22.1-0.7-1.2-1.00.91.0-1.31.31.4-1.21.21.51.30.4-0.4
Mean num. licks in bursts0.70.81.6-1.2-1.0-1.01.11.0-1.01.00.9-0.80.81.00.4-0.40.4
Cd content in liver0.30.40.60.70.60.7-0.7-0.80.6-0.6-0.70.6-0.6-0.8-0.40.1-0.1
Co content in liver1.31.52.2-0.8-1.3-1.21.01.1-1.31.31.4-1.41.41.51.50.7-0.7
Cu content in liver1.31.63.40.81.11.3-0.9-1.21.2-1.3-1.01.5-1.5-0.9-1.8-1.41.4
Fe content in liver0.40.51.11.00.70.8-1.0-0.80.7-0.7-0.60.6-0.6-0.4-0.10.8-0.8
K content in liver0.50.51.1-1.0-0.7-0.70.90.8-0.70.60.5-0.40.40.7-0.3-1.11.1
Mg content in liver0.50.51.8-1.0-0.5-0.60.80.7-0.40.4-0.1-0.10.10.0-0.5-1.31.3
Mn content in liver1.41.67.9-1.4-0.6-0.51.10.8-0.40.3-0.00.2-0.2-0.0-1.5-2.82.8
Na content in liver0.20.30.8-0.10.40.2-0.0-0.10.4-0.4-0.50.4-0.4-0.4-0.8-0.90.9
Rb content in liver0.81.02.70.40.81.0-0.6-0.90.8-0.9-0.71.3-1.3-0.7-1.6-1.01.0
Se content in liver0.00.00.1-0.3-0.2-0.30.30.3-0.20.2-0.0-0.00.00.1-0.0-0.20.2
Sr content in liver0.60.61.80.1-0.5-0.20.00.3-0.60.61.0-0.60.60.91.11.3-1.3
Zn content in liver2.72.96.3-0.7-1.5-1.61.11.4-1.61.71.8-2.02.01.82.51.8-1.8
Bone: minimum diameter0.40.82.30.20.60.9-0.4-0.70.6-0.7-0.71.2-1.2-0.8-1.5-1.21.2
Time in familiar zone, hab. session 15.04.76.5-2.0-2.3-2.42.22.3-2.42.42.3-2.62.62.32.20.3-0.3
Time in novel zone, hab. session 14.03.96.01.42.02.0-1.7-1.92.0-2.1-2.22.3-2.3-2.2-2.5-1.21.2
Total zone transitions, hab. session 10.60.82.6-1.3-0.7-0.71.10.9-0.60.50.1-0.50.50.1-0.4-1.61.6
Total locomotion distance, hab. session 11.82.56.4-2.3-1.4-1.42.01.6-1.31.20.8-1.11.10.8-0.4-2.52.5
Locomotion velocity, hab. session 11.72.55.1-2.3-1.5-1.52.01.7-1.51.41.0-1.31.31.1-0.0-2.12.1
Time in familiar zone, hab. session 24.95.17.2-1.8-2.5-2.42.12.3-2.52.52.7-2.52.52.62.50.8-0.8
Time in novel zone, hab. session 25.65.67.51.82.52.5-2.1-2.42.6-2.6-2.72.7-2.7-2.7-2.7-1.01.0
Total zone transitions, hab. session 21.01.33.3-0.20.80.8-0.3-0.70.9-1.0-1.21.0-1.0-1.2-1.8-1.81.8
Total locomotion distance, hab. session 20.50.62.1-1.2-0.5-0.60.90.7-0.40.40.1-0.40.40.1-0.4-1.41.4
Locomotion velocity, hab. session 20.60.83.2-1.4-0.5-0.61.00.8-0.40.4-0.0-0.40.40.0-0.6-1.81.8
Novel to familiar place preference ratio3.03.15.10.81.91.8-1.3-1.71.9-2.0-2.11.7-1.7-2.2-2.3-1.31.3
Novelty place preference2.12.13.70.51.51.5-1.0-1.41.5-1.6-1.71.4-1.4-1.8-1.9-1.31.3
Time in novel zone, NPP test2.52.64.20.81.71.7-1.3-1.61.8-1.8-1.91.6-1.6-1.9-2.1-1.21.2
Total zone transitions, NPP test0.50.71.4-0.00.80.6-0.3-0.50.8-0.8-1.20.7-0.7-1.1-1.1-0.90.9
Total locomotion distance, NPP test0.40.51.9-0.50.30.20.2-0.10.4-0.4-0.70.4-0.4-0.8-1.1-1.41.4
Locomotion velocity, NPP test0.30.41.8-0.8-0.0-0.20.50.30.0-0.1-0.40.1-0.1-0.4-0.8-1.31.3
Intraocular pressure0.70.92.4-0.3-0.7-0.70.50.7-0.80.90.8-1.11.10.91.51.3-1.3
Delta distance traveled before/after self-admin0.00.00.10.10.20.3-0.2-0.20.2-0.2-0.20.3-0.3-0.1-0.2-0.10.1
Delta ambulatory time before/after self-admin0.10.10.40.00.20.3-0.1-0.20.2-0.3-0.30.4-0.4-0.3-0.6-0.60.6
Parametrial fat weight0.10.10.20.1-0.3-0.40.20.3-0.30.40.4-0.30.30.40.50.3-0.3
Pavlov. Cond. lever latency0.30.31.80.60.10.1-0.5-0.20.1-0.00.2-0.10.10.20.71.3-1.3
Pavlov. Cond. magazine entry latency1.41.82.5-1.1-1.5-1.41.41.4-1.51.61.6-1.51.51.51.40.1-0.1
Pavlov. Cond. change in total contacts0.10.10.30.30.40.6-0.4-0.50.4-0.4-0.40.4-0.4-0.4-0.4-0.20.2
Pavlov. Cond. index score0.40.51.0-1.0-0.7-0.70.90.8-0.70.60.5-0.60.60.50.1-0.90.9
Pavlov. Cond. latency score0.50.71.7-1.1-0.7-0.71.00.8-0.70.60.4-0.60.60.4-0.2-1.31.3
Pavlov. Cond. lever contacts0.40.52.6-0.70.0-0.00.40.20.1-0.2-0.50.2-0.2-0.5-0.9-1.61.6
Pavlov. Cond. magazine entry number0.40.60.70.70.90.8-0.8-0.80.8-0.9-0.80.8-0.8-0.8-0.70.1-0.1
Pavlov. Cond. intertrial magazine entries0.30.30.9-0.0-0.3-0.20.00.1-0.30.40.6-0.60.60.60.91.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-1.1-0.9-0.81.00.9-0.80.80.6-0.70.70.60.2-0.90.9
Pavlov. Cond. response bias0.60.81.0-1.0-1.0-0.91.01.0-0.91.00.9-1.01.00.90.7-0.30.3
Pavlov. Cond. lever latency1.52.02.81.71.61.6-1.6-1.61.5-1.5-1.31.6-1.6-1.4-1.10.2-0.2
Pavlov. Cond. magazine entry latency2.12.53.2-1.8-1.8-1.71.81.8-1.81.81.5-1.71.71.61.2-0.40.4
Pavlov. Cond. change in total contacts0.71.01.5-1.1-1.1-1.01.01.0-1.11.11.1-1.11.11.20.90.1-0.1
Pavlov. Cond. index score2.02.53.3-1.7-1.8-1.71.71.7-1.81.81.6-1.81.81.71.4-0.10.1
Pavlov. Cond. latency score2.02.53.6-1.9-1.8-1.81.81.8-1.81.81.5-1.71.71.61.2-0.40.4
Pavlov. Cond. lever contacts1.31.82.4-1.4-1.5-1.51.41.4-1.51.51.4-1.61.61.51.30.2-0.2
Pavlov. Cond. magazine entry number1.92.43.11.81.81.7-1.7-1.71.8-1.7-1.61.6-1.6-1.6-1.10.4-0.4
Pavlov. Cond. intertrial magazine entries0.71.01.51.21.11.1-1.2-1.21.1-1.0-0.90.7-0.7-0.9-0.30.9-0.9
Pavlov. Cond. lever-magazine prob. diff.2.02.63.4-1.8-1.8-1.71.71.7-1.81.81.7-1.71.71.81.3-0.30.3
Pavlov. Cond. response bias2.12.83.6-1.6-1.9-1.81.71.8-1.91.91.8-1.91.91.91.60.2-0.2
Time in closed arm before self-admin0.50.61.6-0.20.50.5-0.0-0.20.5-0.6-1.00.8-0.8-1.0-1.0-1.31.3
Time in closed arm after self-admin0.30.30.70.60.50.8-0.6-0.70.5-0.5-0.20.8-0.8-0.1-0.1-0.00.0
Time in open arm before self-admin0.50.52.0-0.1-0.8-0.60.20.4-0.80.81.4-0.50.51.40.30.5-0.5
Time in open arm after self-admin0.91.01.41.21.10.9-1.1-1.11.1-1.1-1.10.8-0.8-1.1-1.10.7-0.7
Bone: periosteal estimation1.42.96.60.81.41.7-1.1-1.51.5-1.6-1.52.2-2.2-1.7-2.6-1.71.7
Bone: periosteal perimeter0.40.62.5-0.50.10.30.2-0.10.2-0.3-0.30.8-0.8-0.4-1.5-1.61.6
Bone: post-yield work0.30.50.70.70.70.8-0.7-0.80.7-0.8-0.60.8-0.8-0.7-0.70.1-0.1
Progressive ratio test 1 active lever presses1.21.31.91.21.21.4-1.3-1.31.2-1.2-1.11.3-1.3-0.9-0.90.3-0.3
Progressive ratio test 1 breakpoint1.31.42.11.21.31.4-1.3-1.41.2-1.3-1.21.4-1.4-1.0-1.00.2-0.2
Progressive ratio test 1 inactive lever presses0.10.10.8-0.0-0.20.3-0.2-0.2-0.20.10.80.3-0.30.9-0.3-0.30.3
Progressive ratio test 2 active lever presses0.50.50.90.70.70.9-0.8-0.90.7-0.7-0.51.0-1.0-0.3-0.8-0.10.1
Progressive ratio test 2 breakpoint0.20.30.80.10.30.6-0.3-0.40.3-0.4-0.20.7-0.7-0.1-0.9-0.60.6
Progressive ratio test 2 inactive lever presses0.30.41.00.30.40.8-0.5-0.60.4-0.5-0.20.9-0.9-0.1-1.0-0.50.5
Incentive Sensitization - Responses0.10.10.4-0.2-0.4-0.20.20.3-0.40.40.6-0.20.20.60.1-0.10.1
Incentive Sensitization - Breakpoint0.20.20.5-0.4-0.5-0.30.40.4-0.50.40.7-0.20.20.7-0.0-0.40.4
Sum of active levers in priming session hrs 5-60.40.40.7-0.6-0.6-0.50.60.6-0.60.60.6-0.70.70.60.80.1-0.1
Progressive ratio0.91.11.61.31.21.2-1.3-1.21.2-1.2-0.91.1-1.1-0.9-0.60.6-0.6
Food seeking constrained by brief footshock1.51.93.0-1.4-1.4-1.61.51.6-1.41.51.1-1.71.71.21.3-0.10.1
Seeking ratio, punishment vs. effort2.02.53.5-1.7-1.7-1.81.81.9-1.71.81.4-1.91.91.41.3-0.30.3
Retroperitoneal fat weight2.16.99.33.03.03.0-3.0-3.13.0-2.9-2.72.7-2.7-2.7-1.81.0-1.0
Reaction time number correct0.81.11.81.41.21.0-1.3-1.21.1-1.0-0.90.8-0.8-1.0-0.11.2-1.2
Reaction time mean minus median1.31.82.6-1.6-1.4-1.61.61.5-1.41.41.2-1.51.51.21.0-0.40.4
Reaction time mean minus median AUC1.51.94.3-2.1-1.3-1.41.81.5-1.21.20.7-1.11.10.6-0.0-1.81.8
Reaction time num false alarms0.50.60.90.91.00.9-0.9-0.90.9-0.9-0.90.7-0.7-0.8-0.40.5-0.5
Reaction time num false alarms AUC0.60.81.21.11.00.9-1.1-1.01.0-0.9-0.80.6-0.6-0.8-0.20.9-0.9
Reaction time trials correct on left0.81.11.81.41.21.0-1.3-1.21.1-1.0-0.90.8-0.8-1.0-0.11.2-1.2
Reaction time trials on left0.71.11.71.31.21.0-1.3-1.11.1-1.0-0.90.8-0.8-1.0-0.11.1-1.1
Reaction time mean0.91.22.1-1.4-1.3-1.21.41.3-1.21.20.7-0.90.90.70.3-1.21.2
Reaction time mean AUC0.40.61.3-1.0-0.8-0.71.00.8-0.70.70.3-0.40.40.3-0.1-1.11.1
Median of all reaction times0.40.61.1-0.9-0.8-0.71.00.9-0.80.80.4-0.50.50.4-0.0-1.01.0
Reaction time omissions0.00.10.3-0.0-0.00.2-0.0-0.1-0.0-0.00.10.2-0.20.0-0.4-0.50.5
Reaction time false alarm rate0.10.10.30.20.40.4-0.3-0.40.4-0.5-0.50.3-0.3-0.4-0.4-0.00.0
Reaction time premature initiation rate1.62.13.3-0.9-1.4-1.51.11.4-1.51.51.7-1.71.71.61.81.0-1.0
Reaction time premature initiations1.01.43.3-0.2-0.8-0.90.40.7-0.91.01.3-1.31.31.21.81.7-1.7
Std. dev. reaction times0.70.91.6-1.3-1.1-1.11.21.1-1.01.00.7-0.90.90.70.3-0.90.9
Reaction time trials completed0.71.11.71.31.21.0-1.3-1.11.1-1.0-0.90.8-0.8-1.0-0.11.1-1.1
Reaction time trials AUC0.91.22.11.51.21.1-1.4-1.21.2-1.1-0.90.8-0.8-1.00.01.3-1.3
Run reversals in cocaine runway, females1.61.52.4-1.5-1.4-1.41.51.5-1.41.31.0-1.31.31.00.7-0.70.7
Run reversals in cocaine runway, males2.02.02.7-1.6-1.7-1.41.61.5-1.61.61.6-1.31.31.60.6-0.90.9
Latency to leave start box in cocaine runway0.70.82.5-0.60.40.20.2-0.10.5-0.6-1.00.7-0.7-1.0-1.3-1.61.6
Latency to leave start box in cocaine runway, F1.31.54.8-0.60.60.50.1-0.20.7-0.8-1.31.0-1.0-1.3-1.9-2.22.2
Latency to leave start box in cocaine runway, M0.20.21.00.20.1-0.2-0.1-0.10.00.00.2-0.20.20.20.71.0-1.0
Std. dev. time between licks in bursts0.60.82.3-1.1-0.8-0.60.90.7-0.70.60.8-0.50.50.7-0.3-1.51.5
Total sessions with >9 infusions0.80.92.9-0.00.40.9-0.3-0.60.4-0.6-0.31.2-1.2-0.2-1.7-1.51.5
Short access day 1 total inactive lever presses0.10.10.20.1-0.00.2-0.2-0.2-0.0-0.00.30.3-0.30.4-0.4-0.20.2
Short access day 10 total inactive lever presses0.30.30.90.5-0.20.1-0.4-0.2-0.20.20.9-0.10.10.90.60.9-0.9
Short access day 1 total infusions1.51.64.70.30.81.4-0.8-1.10.9-1.1-0.71.7-1.7-0.6-2.2-1.51.5
Short access day 10 total infusions0.70.81.40.80.81.2-1.0-1.10.8-0.9-0.71.2-1.2-0.5-1.0-0.10.1
Short access total infusions2.02.35.00.81.31.8-1.2-1.51.4-1.5-1.22.0-2.0-1.1-2.2-1.11.1
Short access day 1 locomotion0.10.10.5-0.4-0.3-0.00.20.1-0.30.20.20.1-0.10.5-0.5-0.70.7
Short access day 10 total locomotion1.92.15.8-0.7-1.6-1.31.01.2-1.71.62.3-1.31.32.41.50.5-0.5
Short access total locomotion0.20.20.7-0.5-0.6-0.30.40.3-0.60.50.7-0.20.20.9-0.0-0.40.4
One hour access (0.3 mA shock)0.40.50.80.80.70.8-0.8-0.70.7-0.7-0.60.9-0.9-0.5-0.60.0-0.0
Compulsive drug intake0.30.30.70.40.60.5-0.4-0.40.6-0.5-0.80.6-0.6-0.7-0.5-0.10.1
One hour access (shock baseline)0.20.20.50.60.20.4-0.6-0.40.1-0.10.40.2-0.20.40.20.7-0.7
Social response proportion0.70.71.3-1.1-0.9-1.01.11.1-0.90.90.6-0.80.80.60.3-0.80.8
Social responses7.79.914.1-3.7-3.5-3.73.83.7-3.53.42.9-3.23.23.01.9-1.51.5
Social time0.91.21.81.21.31.1-1.2-1.21.3-1.3-1.21.0-1.0-1.3-0.60.6-0.6
Soleus weight5.716.822.24.24.74.5-4.4-4.54.7-4.6-4.64.3-4.3-4.7-3.20.9-0.9
Bone: stiffness4.46.99.02.22.92.9-2.6-2.82.9-3.0-2.93.0-3.0-2.9-2.9-0.50.5
Tibialis anterior weight1.13.95.62.02.32.2-2.1-2.22.3-2.3-2.42.0-2.0-2.3-1.50.3-0.3
Time to tail flick, vehicle, before self-admin1.61.64.1-1.7-1.3-0.71.51.2-1.21.11.3-0.50.51.20.2-2.02.0
Time to tail flick, vehicle, after self-admin0.50.50.9-0.2-0.5-0.70.30.5-0.60.60.6-0.80.80.71.01.0-1.0
Time to tail flick, test, before self-admin0.90.92.0-1.2-0.9-0.91.11.0-0.90.80.5-0.60.60.6-0.3-1.41.4
Time to tail flick, test, after self-admin0.30.31.5-0.7-0.2-0.10.50.3-0.20.1-0.00.1-0.1-0.1-0.5-1.21.2
Delta time to tail flick, vehicle, before/after SA1.21.23.91.41.00.5-1.1-0.81.0-0.8-1.10.2-0.2-1.00.32.0-2.0
Delta time to tail flick, test, before/after SA0.20.21.00.0-0.2-0.30.10.3-0.20.30.4-0.50.50.31.00.7-0.7
Tibia length1.02.74.1-1.6-1.8-1.91.71.8-1.81.81.6-2.02.01.71.7-0.00.0
Ambulatory time before self-admin0.30.30.6-0.8-0.6-0.60.60.6-0.60.50.6-0.50.50.50.2-0.20.2
Ambulatory time after self-admin0.00.10.2-0.4-0.2-0.10.30.2-0.20.20.2-0.10.10.20.0-0.30.3
Bone: tissue strength4.34.26.51.92.22.2-2.0-2.12.2-2.2-2.12.5-2.5-2.1-2.1-0.20.2
Total heroin consumption2.12.43.5-1.8-1.7-1.81.81.9-1.71.71.5-1.71.71.41.1-0.70.7
Bone: trabecular number0.81.23.5-1.7-0.9-0.91.41.1-0.80.70.2-0.50.50.3-0.6-1.91.9
Bone: trabecular spacing1.11.56.71.50.30.3-1.0-0.60.2-0.10.5-0.20.20.41.62.6-2.6
Bone: trabecular thickness2.42.912.4-1.30.30.50.5-0.10.5-0.7-1.21.1-1.1-1.2-2.7-3.53.5
Bone: trabecular tissue density5.07.110.53.23.03.1-3.2-3.12.9-2.9-2.62.7-2.7-2.6-1.51.3-1.3
Water consumed over 24 hours1.01.32.90.51.01.0-0.7-0.91.1-1.2-1.11.3-1.3-1.1-1.7-1.11.1
Number of responses in last shaping day1.01.03.0-0.8-1.2-0.90.90.9-1.21.11.7-0.80.81.70.6-0.20.2