Hub : Genes

Smarcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Smarcc1 0.03 0.03 3.3e-03 0.03 0.02 0.03 0.03 1.5e-03 2.5e-03 1.7e-03 2.2e-03
2 Adipose mRNA stability Smarcc1 0.08 0.07 8.5e-06 0.04 0.04 0.03 0.04 7.5e-05 7.4e-05 2.2e-04 6.6e-05
3 IL alternative polyA NM_001413573.1 0.26 0.2 7.8e-04 0.09 0.09 0.06 0.07 3.8e-03 4.1e-03 1.5e-02 8.2e-03
4 NAcc gene expression Smarcc1 0.07 0.07 3.9e-06 0.04 0.04 0.04 0.04 1.9e-05 1.0e-05 1.1e-05 1.1e-05
5 IL isoform ratio XM_006243772.4 0.21 0.17 1.9e-03 0.1 0.1 0.09 0.09 2.6e-03 2.3e-03 3.8e-03 2.9e-03
6 PL gene expression Smarcc1 0.06 0.06 6.4e-06 0.04 0.05 0.04 0.04 7.3e-05 6.4e-06 1.4e-05 3.0e-05
7 LHb alternative polyA XM_006243771.4 0.2 0.15 2.8e-03 0.01 0.07 0.03 0.03 1.4e-01 1.1e-02 6.3e-02 6.7e-02
8 LHb isoform ratio XM_006243771.4 0.27 0.17 2.8e-04 0.03 0.1 0.06 0.06 5.4e-02 2.7e-03 1.6e-02 1.6e-02
9 LHb alternative polyA XM_006243772.4 0.2 0.15 3.3e-03 0.02 0.07 0.03 0.03 1.3e-01 1.1e-02 6.3e-02 6.6e-02
10 LHb alternative polyA XM_006243771.4 0.23 0.16 1.2e-03 0.03 0.08 0.04 0.04 6.0e-02 7.3e-03 4.0e-02 3.2e-02
11 Liver gene expression Smarcc1 0.04 0.03 1.0e-04 0.01 0.03 0.02 0.01 2.4e-02 7.4e-04 4.0e-03 8.3e-03
12 Adipose gene expression Smarcc1 0.02 0.02 4.8e-03 0.02 0.02 0 0.02 3.9e-03 4.2e-03 1.1e-01 4.3e-03
13 IL isoform ratio NM_001413573.1 0.23 0.17 7.0e-04 0.11 0.11 0.1 0.11 1.1e-03 1.4e-03 2.5e-03 1.3e-03
14 IL mRNA stability Smarcc1 0.18 0.15 2.6e-03 0.12 0.09 0.1 0.1 8.7e-04 4.3e-03 2.4e-03 2.9e-03
15 IL alternative polyA XM_006243772.4 0.19 0.16 3.7e-03 0.08 0.08 0.07 0.07 6.3e-03 6.6e-03 8.9e-03 9.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.00.00.00.20.20.10.10.20.10.10.1-0.10.1-0.1-0.20.20.20.0
Area under the delay curve1.92.12.4-1.5-1.4-1.4-1.4-1.5-1.4-1.5-1.51.5-1.51.51.5-1.4-1.41.3
BMI with tail0.31.01.91.31.41.31.11.01.01.01.0-0.90.9-0.8-0.70.70.7-0.9
BMI without tail1.73.44.81.72.22.21.91.91.91.91.9-1.91.8-1.8-1.41.81.8-1.6
Body weight6.326.530.05.45.55.25.25.25.25.25.2-5.25.2-5.1-4.85.05.0-4.8
Weight adjusted by age0.30.30.70.50.50.80.60.60.60.60.6-0.60.6-0.5-0.50.50.5-0.8
Bone surface0.00.10.2-0.2-0.2-0.2-0.3-0.3-0.3-0.3-0.30.3-0.30.30.4-0.3-0.30.4
Bone volume0.00.00.1-0.00.0-0.0-0.1-0.1-0.1-0.1-0.10.1-0.10.20.2-0.1-0.10.3
Breakpoint value in progressive ratio session0.10.10.30.30.30.50.30.30.30.30.3-0.30.3-0.3-0.30.30.3-0.5
Number of licking bursts0.20.30.5-0.7-0.6-0.5-0.5-0.5-0.5-0.5-0.50.5-0.50.50.6-0.4-0.40.4
Context. condit. distance diff. score0.00.00.00.00.00.10.00.00.00.00.0-0.00.0-0.00.00.00.0-0.1
Locomotion velocity, session 10.10.10.1-0.2-0.3-0.2-0.2-0.3-0.3-0.3-0.30.3-0.30.30.3-0.3-0.30.1
Locomotion distance, session 10.71.01.51.21.11.11.01.01.00.91.0-0.90.9-0.9-0.90.80.8-1.0
Locomotion velocity, session 20.30.30.4-0.5-0.5-0.5-0.5-0.6-0.6-0.6-0.60.6-0.60.60.7-0.7-0.70.5
Locomotion distance, session 20.00.00.10.0-0.1-0.1-0.1-0.2-0.2-0.2-0.20.2-0.20.30.3-0.3-0.30.1
Locomotion velocity, session 30.10.10.30.40.60.30.30.30.30.30.3-0.30.2-0.2-0.10.20.2-0.4
Locomotion distance, session 31.11.21.6-1.0-0.8-1.1-1.1-1.1-1.1-1.1-1.11.1-1.11.21.3-1.2-1.21.1
Stereotopy head waving bouts, day 30.00.00.10.10.10.10.10.20.20.20.2-0.20.2-0.2-0.20.20.2-0.1
Stereotopy head waving duration, day 30.20.30.40.40.40.40.50.50.50.50.5-0.50.5-0.6-0.60.60.6-0.5
Locomotion velocity, session 70.10.20.30.20.50.10.30.40.40.40.4-0.40.4-0.4-0.20.60.6-0.3
Locomotion distance, session 70.81.11.7-1.2-0.9-1.3-1.0-1.0-1.0-1.0-1.01.0-1.01.01.2-0.9-0.91.0
Stereotopy head waving bouts, day 70.00.00.0-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.10.1-0.10.20.0-0.2-0.20.2
Stereotopy head waving duration, day 70.30.40.50.70.60.70.60.60.60.60.6-0.60.6-0.6-0.70.50.5-0.6
Locomotion velocity, session 80.20.20.40.70.60.50.50.40.40.40.4-0.40.4-0.3-0.30.30.3-0.4
Locomotion distance, session 80.20.20.50.70.70.70.50.50.50.40.4-0.40.4-0.4-0.20.30.3-0.5
Degree of sensitization distance1.21.21.50.90.90.91.11.11.11.11.1-1.11.1-1.2-1.11.21.2-1.1
Degree of sensitization stereotypy0.10.10.10.30.20.30.20.20.20.20.2-0.20.2-0.2-0.30.20.2-0.3
Conditioned locomotion2.93.43.8-1.9-2.0-1.8-1.9-1.9-1.9-1.8-1.81.8-1.81.81.8-1.8-1.81.9
Cocaine response after cond. corrected0.20.30.40.50.40.60.50.50.50.50.5-0.50.5-0.5-0.50.50.5-0.5
Cocaine response after cond. not corrected1.82.02.31.51.41.51.41.41.41.41.4-1.41.4-1.4-1.41.31.3-1.4
Cocaine response before conditioning1.11.42.01.41.41.11.21.21.21.21.2-1.11.1-1.1-1.21.01.0-1.2
Saline control response1.51.92.21.31.31.21.41.41.41.41.4-1.41.4-1.4-1.51.41.4-1.5
Bone: connectivity density0.10.20.4-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.50.5-0.50.50.4-0.4-0.40.4
Bone: cortical apparent density0.20.30.4-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.50.5-0.50.50.4-0.6-0.60.5
Bone: cortical area0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.50.50.5-0.4-0.40.6
Bone: cortical porosity0.00.00.1-0.2-0.3-0.2-0.2-0.1-0.2-0.1-0.10.1-0.10.1-0.00.00.00.1
Bone: cortical porosity0.10.10.4-0.5-0.6-0.5-0.4-0.4-0.4-0.4-0.40.4-0.40.30.2-0.2-0.20.3
Bone: cortical thickness0.10.10.10.30.40.20.30.30.30.30.3-0.30.3-0.3-0.30.40.4-0.2
Bone: cortical thickness0.00.00.0-0.00.0-0.1-0.00.00.00.00.0-0.00.0-0.00.00.10.10.1
Bone: cortical tissue density0.20.30.4-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.50.5-0.50.50.4-0.6-0.60.5
Condit. Reinf. active minus inactive responses0.10.10.20.20.2-0.20.30.30.30.30.3-0.30.3-0.4-0.40.40.4-0.4
Condit. Reinf. active-inactive response ratio0.20.30.40.30.40.10.50.50.50.50.5-0.50.5-0.6-0.60.60.6-0.7
Condit. Reinf. active responses0.00.00.0-0.2-0.1-0.2-0.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.0-0.00.2
Condit. Reinf. inactive responses0.50.61.0-0.7-0.7-0.5-0.8-0.8-0.8-0.8-0.80.8-0.80.80.9-0.8-0.81.0
Incentive salience index mean0.10.10.2-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.30.3-0.30.20.3-0.3-0.30.2
Condit. Reinf. lever presses1.62.12.4-1.4-1.4-1.3-1.4-1.5-1.4-1.5-1.51.5-1.51.51.5-1.6-1.61.4
Condit. Reinf. active minus inactive responses1.92.32.71.71.61.31.61.61.61.61.6-1.61.5-1.5-1.51.41.4-1.5
Condit. Reinf. active-inactive response ratio1.61.62.01.31.41.21.31.31.31.31.3-1.31.3-1.3-1.11.21.2-1.3
Condit. Reinf. active responses1.72.42.91.71.61.31.61.61.61.61.6-1.61.6-1.5-1.61.41.4-1.6
Condit. Reinf. inactive responses0.00.00.10.0-0.2-0.2-0.1-0.1-0.1-0.1-0.10.1-0.10.1-0.1-0.2-0.20.0
Condit. Reinf. lever presses2.33.13.71.91.91.51.81.81.81.81.8-1.81.8-1.7-1.71.71.7-1.7
Condit. Reinf. lever reinforcers received1.92.73.21.81.71.41.71.71.71.61.6-1.61.6-1.6-1.71.51.5-1.7
Conditioned reinforcement - actives0.40.40.6-0.6-0.8-0.5-0.6-0.7-0.6-0.7-0.70.7-0.70.70.6-0.7-0.70.4
Conditioned reinforcement - inactives1.01.21.4-1.2-1.0-1.2-1.1-1.1-1.1-1.1-1.11.1-1.11.11.2-1.0-1.01.1
Conditioned locomotion0.40.40.7-0.6-0.9-0.4-0.6-0.7-0.6-0.7-0.70.7-0.70.70.6-0.8-0.80.4
Patch foraging indifference point 0 sec1.21.92.81.21.21.71.41.41.41.41.4-1.41.4-1.4-1.31.21.2-1.6
Patch foraging indifference point AUC0.10.10.20.20.40.20.30.30.30.30.3-0.30.3-0.3-0.20.20.2-0.3
Delay disc. indifference point, 0s delay0.00.00.1-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.20.20.1-0.2-0.20.1
Delay disc. indifference point, 16s delay0.90.91.0-1.0-0.9-0.8-1.0-1.0-1.0-1.0-1.01.0-1.01.01.0-0.9-0.91.0
Delay disc. indifference point, 2s delay0.20.30.3-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.50.50.6-0.5-0.50.4
Delay disc. indifference point, 24s delay0.80.80.9-0.9-0.8-0.8-0.9-0.9-0.9-0.9-0.90.9-0.90.90.9-0.8-0.80.9
Delay disc. indifference point, 4s delay1.92.02.4-1.6-1.4-1.3-1.4-1.4-1.4-1.4-1.41.4-1.41.41.6-1.4-1.41.2
Delay disc. indifference point, 8s delay2.02.02.3-1.5-1.3-1.4-1.4-1.4-1.4-1.4-1.41.4-1.41.41.5-1.3-1.31.3
Indifference point function ln k0.30.40.8-0.2-0.4-0.5-0.6-0.6-0.6-0.6-0.60.6-0.60.70.5-0.7-0.70.9
Indifference point function log k0.30.40.8-0.2-0.4-0.5-0.6-0.6-0.6-0.6-0.60.6-0.60.70.5-0.7-0.70.9
Patch foraging total patch changes 0 sec1.32.12.91.31.31.71.51.41.51.41.4-1.41.4-1.4-1.51.31.3-1.7
Patch foraging total patch changes 12 sec1.11.41.61.11.11.21.21.21.21.21.2-1.21.2-1.2-1.21.11.1-1.3
Patch foraging total patch changes 18 sec2.33.03.61.51.61.51.71.71.71.81.8-1.81.8-1.8-1.71.81.8-1.9
Patch foraging total patch changes 24 sec3.03.73.91.91.91.71.91.91.91.91.9-1.91.9-1.9-1.92.02.0-1.9
Patch foraging total patch changes 6 sec0.20.30.70.30.40.70.50.50.50.50.5-0.50.5-0.5-0.60.40.4-0.8
Patch foraging time to switch 0 sec0.10.20.3-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.40.4-0.40.40.5-0.2-0.20.4
Patch foraging water rate 0 sec0.10.20.40.60.40.40.40.40.40.40.4-0.40.4-0.4-0.60.20.2-0.5
Patch foraging water rate 12 sec0.20.30.50.50.70.40.50.50.50.50.5-0.50.5-0.5-0.40.40.4-0.4
Patch foraging water rate 18 sec0.00.00.10.10.30.20.10.00.00.00.0-0.00.00.00.10.00.00.2
Patch foraging water rate 24 sec0.70.91.11.01.00.91.01.01.01.01.0-1.01.0-1.0-1.00.80.8-0.9
Patch foraging water rate 6 sec0.20.30.70.80.70.40.60.60.60.60.6-0.60.6-0.5-0.70.60.6-0.4
Seeking ratio, delayed vs. immediate footshock2.73.14.3-1.9-2.1-1.4-1.7-1.7-1.7-1.7-1.71.7-1.71.71.9-1.7-1.71.7
Distance traveled before self-admin0.00.00.1-0.1-0.1-0.2-0.1-0.0-0.1-0.0-0.00.0-0.00.00.00.10.10.3
Distance traveled after self-admin0.30.30.4-0.6-0.6-0.6-0.5-0.5-0.5-0.5-0.50.5-0.50.50.6-0.5-0.50.7
Extensor digitorum longus weight0.20.70.8-0.8-0.9-0.8-0.8-0.8-0.8-0.8-0.80.8-0.80.80.9-0.9-0.90.7
Bone: elastic displacement0.00.00.10.30.20.10.20.20.20.20.2-0.20.2-0.2-0.30.20.2-0.1
Bone: elastic work0.40.50.80.90.90.70.70.70.70.70.7-0.70.7-0.7-0.70.70.7-0.5
Bone: endosteal estimation0.00.10.20.20.30.20.30.30.30.30.3-0.30.3-0.4-0.30.50.5-0.3
Bone: endosteal perimeter1.22.42.8-1.5-1.6-1.4-1.6-1.6-1.6-1.6-1.61.6-1.61.61.5-1.7-1.71.5
Epididymis fat weight0.30.60.80.80.80.60.80.80.80.80.8-0.80.8-0.8-0.70.90.9-0.7
Delta time in closed arm before/after self-admin0.20.20.6-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.50.5-0.50.40.3-0.3-0.30.8
Delta time in open arm before/after self-admin0.20.20.30.30.60.40.50.50.50.50.5-0.50.5-0.5-0.30.50.5-0.4
Diff in mean of infusions in LGA sessions0.00.00.0-0.0-0.10.20.0-0.0-0.0-0.0-0.00.0-0.00.00.1-0.0-0.0-0.1
Delay discount exponential model param2.32.42.81.71.51.51.61.61.61.61.6-1.61.6-1.6-1.71.51.5-1.4
Extinction: sum of active levers before priming0.00.00.2-0.0-0.00.40.10.10.10.10.1-0.10.1-0.1-0.00.10.1-0.3
Active lever presses in extinction session 60.30.30.50.50.60.50.60.60.60.60.6-0.60.6-0.6-0.60.50.5-0.7
Bone: final force0.81.31.51.21.11.21.21.21.21.21.2-1.21.1-1.1-1.21.11.1-1.1
Bone: final moment1.11.72.01.41.31.41.31.31.31.31.3-1.31.3-1.3-1.31.31.3-1.3
Food consumed during 24 hour testing period1.41.62.01.41.21.21.31.31.31.31.3-1.31.3-1.3-1.31.21.2-1.2
Glucose0.30.40.60.70.80.70.70.70.70.60.6-0.60.6-0.6-0.60.60.6-0.5
Heart weight2.53.54.42.11.92.01.91.91.91.91.9-1.91.9-1.9-2.11.71.7-1.7
Delay discount hyperbolic model param2.32.42.81.71.51.51.51.61.61.61.6-1.61.6-1.6-1.71.51.5-1.4
Intermittent access intake day 1-15 change0.70.60.8-0.8-0.9-0.8-0.8-0.8-0.8-0.8-0.80.8-0.80.80.8-0.8-0.80.8
Intermittent access intake escalation0.60.60.7-0.8-0.8-0.8-0.8-0.7-0.7-0.7-0.70.7-0.70.70.8-0.7-0.70.8
Intermittent access intake escalation 20.00.00.00.00.0-0.2-0.00.00.00.00.0-0.00.0-0.1-0.00.10.10.2
Intermitt. access day 1 inactive lever presses0.00.00.0-0.0-0.00.10.0-0.0-0.0-0.0-0.00.0-0.00.00.0-0.0-0.0-0.1
Intermitt. access day 15 inactive lever presses0.60.71.0-1.0-0.8-0.7-0.8-0.8-0.8-0.8-0.80.8-0.80.81.0-0.8-0.80.6
Intermitt. access escalation Index0.00.00.00.00.10.10.00.00.00.00.0-0.00.0-0.0-0.00.00.0-0.1
Intermittent access day 1 total infusions0.00.00.1-0.2-0.20.1-0.1-0.2-0.1-0.2-0.20.2-0.20.20.2-0.2-0.2-0.1
Intermittent access day 15 total infusions0.40.40.7-0.8-0.7-0.5-0.6-0.7-0.6-0.6-0.60.6-0.60.60.8-0.7-0.70.5
Intermittent access terminal intake (last 3 days)0.20.20.3-0.6-0.5-0.2-0.4-0.4-0.4-0.4-0.40.4-0.40.40.6-0.5-0.50.2
Intermittent access total infusions0.50.60.8-0.8-0.9-0.5-0.7-0.8-0.7-0.8-0.80.8-0.80.80.8-0.8-0.80.5
Intermittent access day 1 locomotion0.10.10.2-0.5-0.4-0.1-0.3-0.3-0.3-0.3-0.30.3-0.30.30.5-0.3-0.30.1
Intermittent access day 15 total locomotion0.70.81.0-0.9-0.9-1.0-0.9-0.9-0.9-0.9-0.90.9-0.90.80.9-0.8-0.81.0
Intermittent access total locomotion1.21.31.6-1.1-1.3-1.0-1.1-1.2-1.2-1.2-1.21.2-1.21.21.1-1.2-1.21.0
Intermittent access standard deviation0.10.10.20.20.30.40.40.40.40.40.4-0.40.4-0.4-0.20.40.4-0.4
Left kidney weight0.82.23.61.91.71.81.61.51.51.51.5-1.41.4-1.3-1.31.11.1-1.4
Right kidney weight0.20.61.21.10.91.00.80.70.80.70.7-0.70.7-0.6-0.70.40.4-0.7
Cocaine induced anxiety0.30.40.6-0.7-0.7-0.0-0.5-0.6-0.6-0.6-0.60.6-0.60.60.7-0.8-0.80.0
Post-drug Anxiety0.10.10.2-0.4-0.4-0.1-0.3-0.4-0.3-0.4-0.40.4-0.40.40.4-0.4-0.40.1
Baseline Anxiety0.30.41.0-0.6-0.5-1.0-0.6-0.5-0.6-0.5-0.50.5-0.50.50.6-0.3-0.31.0
Tail length7.021.122.44.34.74.74.64.64.64.64.6-4.64.6-4.7-4.44.74.7-4.3
Length with tail9.635.036.65.96.05.95.96.06.06.06.0-6.06.0-6.0-5.85.95.9-5.6
Length without tail6.414.116.94.13.83.63.83.83.83.83.8-3.83.7-3.7-3.93.63.6-3.7
Times rat made contact with spout0.60.71.00.90.70.80.80.80.80.80.8-0.80.8-0.8-1.00.70.7-0.8
Lifetime Intake0.40.50.6-0.7-0.8-0.6-0.7-0.7-0.7-0.7-0.70.7-0.70.70.7-0.7-0.70.5
Liver weight, left0.10.10.20.20.20.20.30.30.30.30.3-0.30.3-0.4-0.40.50.5-0.4
Liver weight, right1.42.42.61.61.61.61.51.51.51.51.5-1.51.5-1.5-1.51.61.6-1.6
Locomotor activity5.58.810.02.93.13.23.03.03.03.03.0-3.03.0-3.0-2.92.82.8-2.9
Locomotor testing distance5.08.39.52.73.13.02.92.92.92.92.9-2.92.9-2.9-2.72.92.9-2.8
Locomotor testing rearing0.10.20.40.00.40.30.30.40.40.40.4-0.40.4-0.5-0.20.60.6-0.3
Locomotion in novel chamber0.20.20.4-0.2-0.3-0.3-0.4-0.4-0.4-0.4-0.40.5-0.50.50.2-0.6-0.60.4
Locomotion in novel chamber post-restriction0.70.81.11.01.00.80.90.90.90.90.9-0.90.9-0.9-1.00.80.8-0.6
Fecal boli incidents, locomotor time 10.40.51.20.60.61.10.70.70.70.70.7-0.70.7-0.7-0.60.60.6-0.8
Change in fecal boli incidents, locomotor task0.00.00.20.10.1-0.40.10.10.10.10.1-0.10.1-0.1-0.10.20.20.0
Time >=10cm from walls, locomotor time 10.20.20.5-0.3-0.3-0.6-0.4-0.4-0.4-0.4-0.40.4-0.40.40.3-0.3-0.30.7
Bouts of movement, locomotor time 10.00.00.10.10.10.40.20.20.20.20.2-0.20.2-0.2-0.10.10.1-0.3
Total resting periods, locomotor time 10.00.00.10.10.10.30.10.10.10.10.1-0.10.1-0.1-0.00.10.1-0.2
Rest time, locomotor task time 10.60.70.9-0.9-0.9-0.6-0.8-0.8-0.8-0.8-0.80.8-0.80.80.8-0.9-0.90.9
Distance moved, locomotor task time 11.71.82.31.51.41.11.31.31.31.31.3-1.31.3-1.3-1.51.41.4-1.1
Vertical activity count, locomotor time 10.91.01.41.10.91.21.01.01.01.01.0-1.01.0-0.9-1.11.01.0-0.9
Time >=10cm from walls, locomotor time 21.51.51.71.21.21.21.21.31.21.31.3-1.31.3-1.3-1.31.31.3-1.0
Bouts of movement, locomotor time 20.00.00.3-0.30.0-0.5-0.1-0.0-0.1-0.0-0.00.0-0.00.00.20.00.0-0.0
Total resting periods, locomotor time 20.10.20.6-0.6-0.3-0.8-0.4-0.3-0.3-0.3-0.30.3-0.30.30.5-0.2-0.20.3
Rest time, locomotor task time 20.10.10.2-0.4-0.20.0-0.2-0.2-0.2-0.2-0.20.2-0.20.20.4-0.2-0.20.2
Distance moved, locomotor task time 21.11.32.01.41.10.71.11.11.11.11.1-1.11.1-1.1-1.41.11.1-1.0
Vertical activity count, locomotor time 20.10.10.20.50.20.30.30.30.30.30.3-0.30.3-0.3-0.50.30.3-0.2
Light reinforcement 10.71.22.01.01.11.41.11.11.11.11.1-1.11.1-1.1-0.81.11.1-1.0
Light reinforcement 20.10.10.4-0.2-0.1-0.1-0.3-0.3-0.3-0.3-0.30.3-0.30.30.4-0.4-0.40.6
Bone: marrow area0.10.10.20.20.40.30.30.40.30.40.4-0.40.4-0.4-0.30.50.5-0.3
Bone: maximum diameter0.40.80.9-0.8-0.9-0.7-0.9-0.9-0.9-0.9-0.90.9-0.90.90.8-1.0-1.00.8
Bone: maximum force0.71.21.21.11.01.11.11.11.11.11.1-1.11.1-1.1-1.11.11.1-1.0
Bone: maximum moment0.81.31.41.21.11.21.11.11.11.11.1-1.21.2-1.2-1.21.21.2-1.1
Mean time between licks in bursts1.31.92.1-1.3-1.3-1.5-1.4-1.4-1.4-1.4-1.41.4-1.41.41.3-1.4-1.41.4
Mean num. licks in bursts0.81.01.51.21.01.01.01.01.01.01.0-0.90.9-0.9-1.20.80.8-1.0
Cd content in liver2.32.53.21.41.31.41.61.61.61.61.6-1.61.6-1.7-1.81.71.7-1.6
Co content in liver0.00.00.1-0.2-0.0-0.3-0.1-0.0-0.1-0.0-0.00.0-0.0-0.00.10.10.10.2
Cu content in liver4.04.85.22.22.12.32.22.22.22.22.2-2.22.2-2.2-2.22.22.2-2.2
Fe content in liver1.72.12.81.21.11.11.41.41.41.51.5-1.51.5-1.5-1.71.51.5-1.7
K content in liver0.90.91.81.11.11.31.00.90.90.90.9-0.90.9-0.8-0.80.80.8-0.9
Mg content in liver0.00.00.20.20.20.40.0-0.00.0-0.0-0.00.0-0.10.10.2-0.1-0.10.1
Mn content in liver0.60.61.01.01.00.80.80.80.80.80.8-0.80.8-0.7-0.60.70.7-0.8
Na content in liver0.40.50.60.60.50.60.60.70.60.70.7-0.70.7-0.7-0.70.70.7-0.8
Rb content in liver1.01.31.90.60.70.71.01.11.11.11.1-1.21.2-1.3-1.31.41.4-1.3
Se content in liver0.10.10.30.40.40.50.30.30.30.30.3-0.30.3-0.2-0.20.20.20.0
Sr content in liver0.00.00.10.30.30.20.10.00.0-0.0-0.00.0-0.00.10.1-0.1-0.10.2
Zn content in liver4.44.85.92.32.22.42.22.22.22.22.2-2.22.2-2.1-2.22.12.1-2.1
Bone: minimum diameter0.40.81.1-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.90.9-0.90.90.9-0.8-0.81.0
Time in familiar zone, hab. session 11.61.52.4-1.5-1.4-1.4-1.3-1.2-1.2-1.2-1.21.2-1.21.11.2-1.0-1.01.2
Time in novel zone, hab. session 10.80.81.21.10.90.90.90.90.90.90.9-0.90.8-0.8-1.00.80.8-1.0
Total zone transitions, hab. session 10.50.71.11.01.10.80.90.80.90.80.8-0.80.8-0.8-0.70.70.7-0.8
Total locomotion distance, hab. session 10.20.30.50.70.70.50.60.60.60.60.6-0.60.6-0.5-0.50.50.5-0.6
Locomotion velocity, hab. session 10.30.40.60.70.80.60.70.60.60.60.6-0.60.6-0.6-0.50.50.5-0.6
Time in familiar zone, hab. session 20.70.70.9-0.9-0.9-1.0-0.9-0.8-0.8-0.8-0.80.8-0.80.80.8-0.8-0.80.9
Time in novel zone, hab. session 20.00.00.10.20.20.20.20.20.20.20.2-0.20.2-0.2-0.20.20.2-0.3
Total zone transitions, hab. session 20.00.00.20.40.40.30.20.20.20.10.1-0.10.1-0.1-0.00.00.0-0.2
Total locomotion distance, hab. session 20.20.30.50.70.70.70.60.60.60.60.6-0.50.5-0.5-0.50.40.4-0.5
Locomotion velocity, hab. session 20.20.20.40.70.60.60.50.50.50.50.5-0.50.5-0.4-0.40.30.3-0.5
Novel to familiar place preference ratio0.80.80.90.90.90.90.90.90.90.90.9-0.90.9-0.9-0.90.90.9-0.8
Novelty place preference0.80.81.01.00.90.90.90.90.90.90.9-0.90.9-0.9-1.00.90.9-0.8
Time in novel zone, NPP test1.01.11.21.11.01.01.01.01.01.01.0-1.01.0-1.0-1.11.01.0-1.0
Total zone transitions, NPP test2.13.04.52.12.02.01.81.71.71.71.7-1.71.6-1.5-1.51.51.5-1.7
Total locomotion distance, NPP test1.01.41.91.41.41.41.21.21.21.11.1-1.11.1-1.1-1.11.01.0-1.2
Locomotion velocity, NPP test1.11.52.21.51.51.51.31.21.21.21.2-1.21.2-1.1-1.11.01.0-1.2
Intraocular pressure1.01.41.70.91.01.01.11.21.21.21.2-1.21.2-1.3-1.21.31.3-1.1
Delta distance traveled before/after self-admin0.10.10.3-0.4-0.4-0.1-0.3-0.3-0.3-0.3-0.30.4-0.40.40.5-0.5-0.50.2
Delta ambulatory time before/after self-admin0.30.30.50.40.60.70.60.60.60.60.6-0.60.5-0.5-0.30.50.5-0.6
Parametrial fat weight1.22.32.61.51.61.61.61.61.61.51.5-1.51.5-1.5-1.41.41.4-1.5
Pavlov. Cond. lever latency5.67.17.82.62.52.52.62.72.62.72.7-2.72.7-2.7-2.82.82.8-2.6
Pavlov. Cond. magazine entry latency6.98.99.3-3.0-3.0-3.0-3.0-3.0-3.0-3.0-3.03.0-3.03.03.0-3.0-3.02.8
Pavlov. Cond. change in total contacts1.92.12.3-1.5-1.5-1.5-1.4-1.4-1.4-1.4-1.41.4-1.41.41.4-1.4-1.41.4
Pavlov. Cond. index score7.08.89.3-3.0-3.0-2.9-2.9-3.0-3.0-3.0-3.03.0-3.03.03.0-3.0-3.02.8
Pavlov. Cond. latency score6.88.69.1-2.9-2.9-2.9-2.9-2.9-2.9-3.0-3.03.0-3.03.03.0-3.0-3.02.8
Pavlov. Cond. lever contacts3.23.84.4-1.8-1.9-1.8-1.9-1.9-1.9-2.0-2.02.0-2.02.02.0-2.1-2.11.9
Pavlov. Cond. magazine entry number8.010.010.33.23.23.13.23.23.23.23.2-3.23.2-3.2-3.13.23.2-3.0
Pavlov. Cond. intertrial magazine entries0.40.40.60.50.70.60.60.70.60.70.7-0.70.7-0.7-0.60.80.8-0.4
Pavlov. Cond. lever-magazine prob. diff.6.37.88.1-2.8-2.8-2.7-2.8-2.8-2.8-2.8-2.82.8-2.82.82.8-2.9-2.92.7
Pavlov. Cond. response bias7.59.29.6-3.0-3.0-2.9-3.0-3.0-3.0-3.0-3.03.0-3.03.13.0-3.1-3.12.9
Pavlov. Cond. lever latency0.30.40.7-0.8-0.8-0.5-0.7-0.7-0.7-0.6-0.60.6-0.60.60.6-0.6-0.60.6
Pavlov. Cond. magazine entry latency0.20.20.3-0.2-0.2-0.3-0.4-0.4-0.4-0.5-0.50.5-0.50.50.5-0.5-0.50.5
Pavlov. Cond. change in total contacts2.12.93.51.91.81.61.71.71.71.71.7-1.71.7-1.7-1.61.71.7-1.6
Pavlov. Cond. index score0.00.10.20.40.40.20.20.20.20.20.2-0.20.2-0.1-0.10.10.1-0.1
Pavlov. Cond. latency score0.00.00.10.40.40.20.20.10.20.10.1-0.10.1-0.1-0.00.10.1-0.0
Pavlov. Cond. lever contacts0.91.21.51.21.21.01.11.11.11.11.1-1.11.1-1.0-1.01.01.0-1.0
Pavlov. Cond. magazine entry number0.40.50.70.50.60.60.70.70.70.80.8-0.80.8-0.8-0.80.80.8-0.8
Pavlov. Cond. intertrial magazine entries0.40.50.9-1.0-0.9-0.9-0.8-0.7-0.7-0.7-0.70.7-0.70.60.6-0.6-0.60.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.40.40.20.20.20.20.10.1-0.10.1-0.1-0.00.10.1-0.1
Pavlov. Cond. response bias0.00.00.10.30.30.10.20.10.20.10.1-0.10.1-0.1-0.00.10.1-0.1
Time in closed arm before self-admin1.51.71.81.41.31.11.31.31.31.31.3-1.31.3-1.3-1.31.21.2-1.3
Time in closed arm after self-admin0.00.00.00.20.0-0.10.00.00.00.00.0-0.00.0-0.0-0.20.10.10.2
Time in open arm before self-admin1.01.11.2-1.0-1.1-0.7-1.1-1.1-1.1-1.1-1.11.1-1.11.11.0-0.9-0.91.1
Time in open arm after self-admin0.20.20.3-0.5-0.4-0.3-0.4-0.4-0.4-0.4-0.40.4-0.40.40.5-0.4-0.40.5
Bone: periosteal estimation0.00.00.0-0.00.10.00.00.00.00.00.0-0.00.1-0.1-0.00.10.10.0
Bone: periosteal perimeter1.22.02.1-1.4-1.5-1.4-1.4-1.4-1.4-1.4-1.41.4-1.41.41.4-1.5-1.51.4
Bone: post-yield work0.00.00.10.20.10.20.20.20.20.20.2-0.20.2-0.2-0.10.10.1-0.0
Progressive ratio test 1 active lever presses0.00.00.0-0.2-0.10.0-0.1-0.1-0.1-0.1-0.10.1-0.10.10.2-0.2-0.2-0.1
Progressive ratio test 1 breakpoint0.00.00.1-0.3-0.2-0.1-0.2-0.2-0.2-0.2-0.20.2-0.20.20.3-0.2-0.2-0.0
Progressive ratio test 1 inactive lever presses0.40.40.6-0.8-0.7-0.6-0.7-0.7-0.7-0.7-0.70.7-0.70.70.8-0.7-0.70.4
Progressive ratio test 2 active lever presses0.91.01.2-1.1-1.1-0.7-1.0-1.0-1.0-1.0-1.01.0-1.01.01.1-1.1-1.10.7
Progressive ratio test 2 breakpoint0.70.81.1-0.9-1.0-0.6-0.8-0.9-0.9-0.9-0.90.9-0.90.90.9-1.0-1.00.5
Progressive ratio test 2 inactive lever presses2.02.32.8-1.6-1.7-1.2-1.5-1.5-1.5-1.6-1.61.6-1.61.61.6-1.6-1.61.1
Incentive Sensitization - Responses1.61.61.9-1.3-1.3-1.1-1.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.4-1.41.1
Incentive Sensitization - Breakpoint1.51.61.8-1.3-1.3-1.0-1.2-1.3-1.3-1.3-1.31.3-1.31.31.3-1.4-1.41.0
Sum of active levers in priming session hrs 5-60.70.60.90.80.80.80.80.80.80.80.8-0.80.8-0.8-0.80.70.7-0.9
Progressive ratio3.54.14.72.11.92.22.02.02.02.02.0-2.02.0-2.0-2.12.02.0-1.9
Food seeking constrained by brief footshock0.81.01.5-0.7-0.8-1.2-1.0-1.0-1.0-1.0-1.01.0-1.01.00.7-1.1-1.11.2
Seeking ratio, punishment vs. effort5.76.97.9-2.6-2.4-2.8-2.6-2.6-2.6-2.6-2.62.6-2.62.62.6-2.7-2.72.7
Retroperitoneal fat weight0.61.92.31.41.51.31.41.41.41.41.4-1.41.4-1.4-1.31.41.4-1.1
Reaction time number correct0.50.71.3-0.9-0.7-1.1-0.8-0.8-0.8-0.8-0.80.8-0.70.70.7-0.8-0.81.1
Reaction time mean minus median0.10.10.30.40.30.50.30.30.30.20.2-0.20.2-0.2-0.20.10.1-0.2
Reaction time mean minus median AUC0.20.30.40.50.50.60.50.50.50.50.5-0.50.5-0.5-0.40.40.4-0.4
Reaction time num false alarms0.30.40.8-0.9-0.8-0.6-0.7-0.6-0.6-0.6-0.60.6-0.60.60.7-0.6-0.60.4
Reaction time num false alarms AUC0.10.10.2-0.5-0.4-0.3-0.3-0.2-0.2-0.2-0.20.2-0.20.20.3-0.2-0.20.0
Reaction time trials correct on left0.50.71.3-0.9-0.7-1.1-0.8-0.8-0.8-0.8-0.80.8-0.70.70.7-0.8-0.81.1
Reaction time trials on left0.50.71.4-0.9-0.8-1.1-0.9-0.8-0.8-0.8-0.80.8-0.80.80.7-0.8-0.81.2
Reaction time mean0.00.00.00.10.0-0.10.00.00.00.10.1-0.10.1-0.1-0.20.10.10.0
Reaction time mean AUC0.00.00.0-0.0-0.1-0.2-0.1-0.0-0.0-0.0-0.00.0-0.00.0-0.10.00.00.1
Median of all reaction times0.00.00.00.0-0.0-0.2-0.00.00.00.00.0-0.00.0-0.1-0.20.20.20.0
Reaction time omissions0.20.30.5-0.7-0.7-0.7-0.5-0.5-0.5-0.5-0.50.5-0.40.40.4-0.4-0.40.4
Reaction time false alarm rate0.00.00.1-0.3-0.30.1-0.1-0.1-0.1-0.1-0.10.1-0.10.10.2-0.1-0.1-0.3
Reaction time premature initiation rate2.33.03.91.61.71.71.81.81.81.81.8-1.81.8-1.8-1.51.61.6-2.0
Reaction time premature initiations1.01.41.61.11.21.01.21.21.21.21.2-1.21.2-1.2-1.01.01.0-1.3
Std. dev. reaction times0.10.10.10.30.30.30.30.30.30.30.3-0.30.3-0.3-0.30.20.2-0.3
Reaction time trials completed0.50.71.4-0.9-0.8-1.1-0.9-0.8-0.8-0.8-0.80.8-0.80.80.7-0.8-0.81.2
Reaction time trials AUC0.70.91.7-1.0-0.9-1.3-1.0-0.9-0.9-0.9-0.90.9-0.90.90.8-0.9-0.91.3
Run reversals in cocaine runway, females2.01.93.5-1.2-1.1-1.8-1.4-1.4-1.4-1.4-1.41.3-1.31.31.2-1.2-1.21.9
Run reversals in cocaine runway, males0.80.71.10.90.81.10.90.80.80.80.8-0.80.8-0.8-0.90.80.8-1.1
Latency to leave start box in cocaine runway0.50.50.70.70.60.80.70.70.70.70.7-0.70.7-0.6-0.70.80.8-0.8
Latency to leave start box in cocaine runway, F1.31.41.61.31.11.21.21.21.21.21.2-1.21.2-1.2-1.31.11.1-1.2
Latency to leave start box in cocaine runway, M0.20.20.3-0.5-0.4-0.2-0.4-0.4-0.4-0.4-0.40.4-0.50.50.5-0.2-0.20.2
Std. dev. time between licks in bursts4.85.76.2-2.4-2.4-2.5-2.4-2.4-2.4-2.4-2.42.4-2.42.42.4-2.3-2.32.5
Total sessions with >9 infusions0.10.10.2-0.4-0.5-0.4-0.4-0.3-0.4-0.3-0.30.3-0.30.30.4-0.3-0.30.4
Short access day 1 total inactive lever presses4.75.37.1-2.3-2.3-2.7-2.4-2.3-2.3-2.3-2.32.3-2.32.22.3-2.0-2.02.5
Short access day 10 total inactive lever presses0.00.00.0-0.2-0.10.20.0-0.0-0.0-0.0-0.00.0-0.00.00.20.00.0-0.2
Short access day 1 total infusions1.01.11.3-1.1-1.1-1.1-1.1-1.0-1.1-1.0-1.01.0-1.01.01.1-1.0-1.01.0
Short access day 10 total infusions0.10.10.1-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.30.3-0.30.30.3-0.3-0.30.2
Short access total infusions0.70.70.9-0.8-0.9-1.0-0.9-0.9-0.9-0.9-0.90.9-0.90.80.8-0.8-0.80.9
Short access day 1 locomotion0.10.10.2-0.2-0.4-0.2-0.2-0.2-0.2-0.2-0.20.2-0.20.30.2-0.3-0.30.2
Short access day 10 total locomotion0.00.00.00.20.10.10.10.10.10.10.1-0.10.1-0.1-0.20.10.1-0.1
Short access total locomotion0.00.00.1-0.1-0.30.1-0.0-0.1-0.1-0.1-0.10.1-0.10.10.1-0.2-0.2-0.2
One hour access (0.3 mA shock)0.20.30.3-0.6-0.6-0.5-0.5-0.5-0.5-0.5-0.50.5-0.50.50.6-0.5-0.50.5
Compulsive drug intake0.10.10.5-0.2-0.1-0.5-0.2-0.2-0.2-0.2-0.20.2-0.20.10.20.00.00.7
One hour access (shock baseline)0.10.10.1-0.4-0.40.1-0.2-0.3-0.2-0.3-0.30.3-0.30.30.4-0.4-0.4-0.2
Social response proportion0.60.61.10.90.80.50.80.80.80.80.8-0.80.8-0.8-1.10.80.8-0.7
Social responses0.40.60.90.80.80.90.80.70.70.70.7-0.70.7-0.7-0.80.60.6-0.8
Social time0.30.40.5-0.6-0.6-0.4-0.6-0.7-0.7-0.7-0.70.7-0.70.70.7-0.6-0.60.7
Soleus weight3.710.911.93.53.53.43.33.33.33.33.3-3.33.3-3.2-3.23.33.3-3.1
Bone: stiffness0.10.20.30.40.30.50.40.50.50.50.5-0.50.5-0.5-0.50.50.5-0.5
Tibialis anterior weight0.00.00.00.20.10.20.10.10.10.10.1-0.10.1-0.1-0.00.10.10.0
Time to tail flick, vehicle, before self-admin2.12.22.71.51.41.41.41.41.41.41.4-1.41.4-1.4-1.61.61.6-1.5
Time to tail flick, vehicle, after self-admin0.70.81.41.00.90.90.90.90.90.90.9-0.90.9-0.8-0.90.60.6-1.2
Time to tail flick, test, before self-admin0.10.10.30.50.40.50.40.30.30.30.3-0.30.3-0.3-0.30.30.3-0.3
Time to tail flick, test, after self-admin0.10.10.2-0.2-0.40.0-0.2-0.3-0.2-0.3-0.30.3-0.30.30.2-0.2-0.2-0.0
Delta time to tail flick, vehicle, before/after SA0.50.50.9-0.6-0.6-0.6-0.6-0.7-0.6-0.7-0.70.7-0.70.70.7-0.9-0.90.4
Delta time to tail flick, test, before/after SA0.40.30.5-0.6-0.7-0.6-0.6-0.6-0.6-0.6-0.60.6-0.60.60.6-0.6-0.60.3
Tibia length6.718.921.84.74.74.64.54.44.44.34.3-4.34.3-4.2-4.14.14.1-4.1
Ambulatory time before self-admin0.10.10.3-0.4-0.4-0.6-0.4-0.3-0.4-0.3-0.30.3-0.30.30.4-0.2-0.20.5
Ambulatory time after self-admin0.00.00.1-0.3-0.2-0.3-0.2-0.2-0.2-0.2-0.20.2-0.20.20.3-0.1-0.10.3
Bone: tissue strength2.82.82.91.61.71.51.61.71.71.71.7-1.71.7-1.7-1.61.71.7-1.6
Total heroin consumption1.11.31.51.01.21.11.21.21.21.21.2-1.21.2-1.2-0.91.11.1-1.0
Bone: trabecular number0.61.01.2-0.9-0.9-1.1-1.0-1.0-1.0-1.0-1.01.0-1.01.01.0-1.0-1.01.1
Bone: trabecular spacing1.41.92.01.21.41.41.31.41.41.41.4-1.41.4-1.4-1.31.41.4-1.3
Bone: trabecular thickness0.00.00.10.40.30.20.20.20.20.10.1-0.10.1-0.1-0.20.10.10.0
Bone: trabecular tissue density0.30.40.50.60.70.70.60.60.60.60.6-0.60.6-0.6-0.50.50.5-0.6
Water consumed over 24 hours0.00.00.00.2-0.10.1-0.0-0.0-0.0-0.1-0.10.1-0.10.1-0.1-0.2-0.20.0
Number of responses in last shaping day0.80.81.2-1.1-1.0-0.7-0.9-0.9-0.9-0.9-0.90.9-0.90.91.1-0.9-0.90.6