Hub : Genes

Smarcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Smarcc1 0.04 0.04 1.7e-05 0.03 0.03 0.03 0.03 3.9e-05 6.8e-05 4.7e-05 8.8e-05
2 Adipose mRNA stability Smarcc1 0.08 0.07 2.8e-05 0.03 0.03 0.03 0.03 1.1e-04 2.6e-04 5.1e-04 2.1e-04
3 Brain mRNA stability Smarcc1 0.03 0.03 1.9e-03 0.02 0.02 0.02 0.01 5.8e-03 6.2e-03 6.0e-03 1.3e-02
4 LHb alternative polyA XM_006243772.5 0.21 0.16 1.7e-03 0.04 0.08 0.02 0.07 4.1e-02 5.2e-03 9.6e-02 9.1e-03
5 LHb alternative polyA XM_006243771.5 0.22 0.16 1.4e-03 0.04 0.09 0.03 0.08 3.3e-02 4.1e-03 7.1e-02 6.7e-03
6 LHb alternative polyA XM_006243771.5 0.24 0.17 7.4e-04 0.06 0.1 0.04 0.09 1.3e-02 2.9e-03 3.6e-02 3.1e-03
7 Liver mRNA stability Smarcc1 0.02 0.02 4.8e-03 0.02 0.02 0.02 0.02 6.3e-03 2.4e-03 4.6e-03 6.4e-03
8 Liver gene expression Smarcc1 0.06 0.04 1.6e-07 0.04 0.06 0.04 0.04 3.5e-05 5.0e-07 1.7e-05 2.2e-05
9 IL alternative polyA NM_001413573.1 0.26 0.18 2.4e-04 0.12 0.12 0.12 0.11 8.7e-04 7.9e-04 7.6e-04 1.1e-03
10 IL alternative polyA XM_006243772.5 0.3 0.24 4.2e-04 0.12 0.12 0.13 0.13 6.5e-04 6.6e-04 4.3e-04 4.8e-04
11 pVTA alternative polyA NM_001413573.1 0.03 0.04 4.7e-03 0.03 0.02 0.02 0.02 4.1e-03 8.4e-03 1.0e-02 9.0e-03
12 PL gene expression Smarcc1 0.05 0.05 5.6e-05 0.04 0.04 0.04 0.04 4.5e-05 5.3e-05 6.5e-05 3.6e-05
13 IL mRNA stability Smarcc1 0.21 0.16 1.2e-03 0.12 0.09 0.11 0.1 6.6e-04 3.2e-03 1.6e-03 2.5e-03
14 NAcc mRNA stability Smarcc1 0.01 0.02 9.5e-03 0.01 0.01 0.02 0.02 2.1e-03 4.1e-03 1.2e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.10.40.00.10.0-0.00.00.0-0.0-0.00.4-0.40.1-0.50.30.6
Area under the delay curve1.51.82.1-1.4-1.11.41.4-1.4-1.41.41.41.3-1.4-1.3-1.31.31.3
BMI with tail0.10.20.80.90.6-0.3-0.40.40.3-0.3-0.3-0.50.70.00.8-0.3-0.4
BMI without tail0.51.62.51.61.5-1.1-1.21.21.2-1.2-1.2-1.31.31.11.3-1.2-1.0
Body weight4.921.225.55.04.8-4.4-4.64.64.5-4.5-4.5-4.74.74.34.7-4.7-4.4
Weight adjusted by age0.00.00.2-0.0-0.0-0.1-0.10.10.1-0.1-0.1-0.30.3-0.00.2-0.4-0.3
Bone surface0.10.30.5-0.4-0.40.70.5-0.5-0.50.50.50.6-0.6-0.5-0.50.40.5
Bone volume0.10.10.3-0.2-0.20.40.3-0.3-0.30.30.30.4-0.6-0.3-0.50.20.5
Breakpoint value in progressive ratio session0.10.10.3-0.5-0.30.30.3-0.3-0.30.30.30.4-0.3-0.3-0.20.60.4
Number of licking bursts0.10.20.4-0.7-0.60.60.5-0.5-0.50.50.50.4-0.2-0.5-0.10.50.1
Context. condit. distance diff. score0.00.00.2-0.1-0.10.20.0-0.0-0.00.00.00.10.1-0.10.20.50.2
Locomotion velocity, session 10.10.10.3-0.2-0.30.20.3-0.3-0.30.30.30.4-0.4-0.4-0.40.50.6
Locomotion distance, session 10.60.81.41.21.1-0.9-0.90.90.9-0.9-0.9-0.90.80.70.8-0.9-0.6
Locomotion velocity, session 20.40.40.6-0.5-0.60.80.7-0.7-0.70.70.70.6-0.6-0.8-0.50.70.6
Locomotion distance, session 20.10.10.2-0.0-0.10.40.3-0.3-0.30.30.30.2-0.4-0.5-0.40.10.5
Locomotion velocity, session 30.10.10.30.50.5-0.0-0.30.30.3-0.2-0.2-0.0-0.10.20.1-0.00.2
Locomotion distance, session 31.11.21.9-0.8-0.71.11.0-1.0-1.01.11.11.3-1.3-1.0-1.21.31.4
Stereotopy head waving bouts, day 30.10.20.70.00.0-0.1-0.10.10.1-0.1-0.1-0.50.60.10.5-0.7-0.9
Stereotopy head waving duration, day 30.30.30.70.30.3-0.5-0.50.50.5-0.5-0.5-0.70.80.50.7-0.7-0.8
Locomotion velocity, session 70.20.20.50.30.7-0.3-0.50.50.5-0.5-0.6-0.10.00.7-0.1-0.20.1
Locomotion distance, session 70.91.12.0-1.0-0.71.00.9-0.9-0.90.90.91.3-1.3-0.7-1.41.21.4
Stereotopy head waving bouts, day 70.00.00.00.0-0.10.00.0-0.0-0.00.00.0-0.1-0.0-0.1-0.0-0.2-0.0
Stereotopy head waving duration, day 70.30.30.40.60.6-0.6-0.60.60.6-0.6-0.6-0.60.60.50.6-0.5-0.4
Locomotion velocity, session 80.10.20.50.70.7-0.3-0.40.40.4-0.4-0.4-0.30.30.30.3-0.2-0.1
Locomotion distance, session 80.10.10.30.50.6-0.0-0.30.30.3-0.3-0.3-0.10.10.10.10.20.4
Degree of sensitization distance1.31.31.71.01.1-1.2-1.21.21.2-1.2-1.2-1.11.11.30.9-1.2-1.1
Degree of sensitization stereotypy0.00.00.10.30.2-0.2-0.20.20.2-0.2-0.2-0.20.00.20.0-0.30.0
Conditioned locomotion3.33.84.7-1.9-2.01.81.9-1.9-1.91.91.92.0-2.1-1.9-2.21.82.0
Cocaine response after cond. corrected0.40.51.20.40.5-0.5-0.50.50.5-0.5-0.5-0.81.00.61.0-0.6-1.1
Cocaine response after cond. not corrected2.02.33.61.31.4-1.4-1.41.41.4-1.4-1.4-1.71.81.41.8-1.6-1.9
Cocaine response before conditioning1.01.21.71.31.2-1.0-1.11.11.1-1.1-1.1-1.00.91.01.0-1.1-0.9
Saline control response0.81.12.10.90.9-1.1-1.11.11.1-1.1-1.1-1.00.71.10.7-1.4-1.0
Bone: connectivity density0.50.72.0-0.6-0.70.60.6-0.6-0.60.60.61.1-1.1-0.6-1.11.21.4
Bone: cortical apparent density0.20.30.6-0.5-0.50.40.5-0.5-0.50.50.50.6-0.6-0.5-0.60.70.8
Bone: cortical area0.10.20.6-0.6-0.50.80.5-0.5-0.50.50.5-0.0-0.0-0.50.0-0.3-0.5
Bone: cortical porosity0.20.20.5-0.4-0.40.30.3-0.3-0.30.20.20.5-0.7-0.2-0.70.40.7
Bone: cortical porosity0.10.20.5-0.4-0.30.20.2-0.2-0.20.20.20.5-0.7-0.1-0.70.30.6
Bone: cortical thickness0.30.52.10.20.3-0.0-0.30.30.3-0.3-0.3-0.90.80.30.8-1.3-1.4
Bone: cortical thickness0.00.00.0-0.1-0.00.20.0-0.0-0.00.00.00.0-0.00.00.0-0.1-0.2
Bone: cortical tissue density0.20.30.6-0.5-0.50.40.5-0.5-0.50.50.50.6-0.6-0.4-0.60.70.8
Condit. Reinf. active minus inactive responses0.10.10.20.20.3-0.4-0.40.40.4-0.4-0.4-0.40.50.50.3-0.3-0.4
Condit. Reinf. active-inactive response ratio0.30.40.50.40.4-0.7-0.60.60.6-0.6-0.6-0.60.70.70.6-0.5-0.7
Condit. Reinf. active responses0.00.00.1-0.1-0.00.10.0-0.0-0.00.00.00.00.10.10.10.3-0.0
Condit. Reinf. inactive responses0.50.60.9-0.8-0.71.00.8-0.8-0.80.80.80.8-0.7-0.8-0.70.90.7
Incentive salience index mean0.00.00.1-0.2-0.20.30.2-0.2-0.20.20.20.2-0.1-0.2-0.10.30.2
Condit. Reinf. lever presses1.42.02.4-1.3-1.41.61.4-1.4-1.41.41.51.5-1.4-1.5-1.21.51.3
Condit. Reinf. active minus inactive responses1.72.13.61.61.4-1.3-1.41.41.4-1.4-1.3-1.61.41.31.4-1.9-1.6
Condit. Reinf. active-inactive response ratio1.61.92.91.41.4-1.2-1.31.31.3-1.3-1.3-1.51.41.21.3-1.7-1.5
Condit. Reinf. active responses1.42.03.21.51.3-1.4-1.31.31.3-1.3-1.3-1.51.31.31.3-1.8-1.5
Condit. Reinf. inactive responses0.10.10.2-0.3-0.50.20.3-0.3-0.30.30.30.4-0.3-0.3-0.30.40.4
Condit. Reinf. lever presses2.12.93.71.91.8-1.6-1.71.71.7-1.6-1.6-1.81.61.61.6-1.9-1.6
Condit. Reinf. lever reinforcers received1.82.43.91.71.4-1.5-1.51.51.5-1.5-1.5-1.71.51.41.5-2.0-1.7
Conditioned reinforcement - actives1.93.23.9-1.8-1.92.01.9-1.9-1.91.81.91.7-1.5-1.9-1.42.01.6
Conditioned reinforcement - inactives1.62.43.9-1.6-1.72.01.7-1.7-1.71.71.71.3-1.4-1.6-1.40.90.8
Conditioned locomotion0.40.60.8-0.6-0.80.80.7-0.7-0.70.70.70.7-0.7-0.9-0.80.70.9
Patch foraging indifference point 0 sec0.81.41.91.41.1-1.3-1.41.41.4-1.4-1.4-1.01.01.21.1-0.8-0.6
Patch foraging indifference point AUC0.00.00.10.20.2-0.1-0.10.10.1-0.1-0.1-0.20.10.20.0-0.3-0.1
Delay disc. indifference point, 0s delay0.00.00.0-0.00.10.10.0-0.0-0.00.00.0-0.20.2-0.10.0-0.2-0.2
Delay disc. indifference point, 16s delay0.91.01.2-1.0-0.81.01.0-1.0-1.01.01.01.0-1.0-0.9-1.01.11.0
Delay disc. indifference point, 2s delay0.20.30.4-0.6-0.30.50.5-0.5-0.50.50.50.5-0.5-0.6-0.60.40.5
Delay disc. indifference point, 24s delay0.91.01.4-1.0-0.81.01.0-1.0-1.01.01.01.1-1.1-1.0-1.11.21.1
Delay disc. indifference point, 4s delay1.51.62.1-1.4-1.11.31.3-1.3-1.31.31.31.2-1.2-1.3-1.11.21.1
Delay disc. indifference point, 8s delay1.82.12.3-1.5-1.41.51.5-1.5-1.51.51.51.5-1.5-1.4-1.41.51.4
Indifference point function ln k0.30.60.8-0.5-0.60.80.7-0.7-0.70.70.70.8-0.8-0.8-0.80.90.9
Indifference point function log k0.30.60.8-0.5-0.60.80.7-0.7-0.70.70.70.8-0.8-0.8-0.80.90.9
Patch foraging total patch changes 0 sec0.81.62.11.41.1-1.4-1.41.41.4-1.4-1.4-1.21.21.21.2-0.9-0.8
Patch foraging total patch changes 12 sec0.91.11.31.10.9-1.1-1.11.11.1-1.1-1.1-1.01.01.01.0-1.0-0.9
Patch foraging total patch changes 18 sec1.82.73.51.61.5-1.7-1.71.71.7-1.7-1.7-1.61.51.91.4-1.7-1.4
Patch foraging total patch changes 24 sec1.93.23.82.01.9-1.8-1.91.91.9-1.9-1.9-1.81.71.81.6-1.7-1.5
Patch foraging total patch changes 6 sec0.10.20.30.60.3-0.6-0.50.50.5-0.5-0.5-0.30.10.30.2-0.10.2
Patch foraging time to switch 0 sec0.10.20.3-0.5-0.50.40.5-0.5-0.50.50.50.4-0.4-0.4-0.30.50.3
Patch foraging water rate 0 sec0.20.40.80.50.3-0.6-0.50.50.5-0.5-0.5-0.70.70.40.7-0.9-0.9
Patch foraging water rate 12 sec0.20.40.60.60.5-0.7-0.60.60.6-0.6-0.6-0.70.70.50.6-0.8-0.7
Patch foraging water rate 18 sec0.10.20.60.30.4-0.2-0.20.20.2-0.2-0.2-0.50.50.10.6-0.7-0.8
Patch foraging water rate 24 sec0.91.32.01.01.0-1.2-1.01.01.0-1.0-1.0-1.31.30.91.3-1.3-1.4
Patch foraging water rate 6 sec0.50.71.30.90.9-0.9-0.70.70.7-0.7-0.7-0.80.70.80.7-1.2-1.0
Seeking ratio, delayed vs. immediate footshock1.82.22.8-1.7-1.61.71.6-1.6-1.61.61.61.1-1.4-1.7-1.60.50.9
Distance traveled before self-admin0.20.30.6-0.7-0.50.40.6-0.6-0.60.60.60.6-0.4-0.6-0.50.70.4
Distance traveled after self-admin0.20.20.5-0.7-0.50.40.5-0.5-0.50.50.50.3-0.3-0.5-0.30.20.1
Extensor digitorum longus weight0.20.71.1-0.7-0.90.90.8-0.8-0.80.80.80.9-0.7-0.9-0.51.00.7
Bone: elastic displacement0.10.10.30.20.1-0.2-0.20.20.2-0.2-0.2-0.30.40.20.5-0.3-0.5
Bone: elastic work0.40.51.10.70.7-0.4-0.60.60.6-0.6-0.6-0.80.90.50.9-0.9-1.0
Bone: endosteal estimation0.00.00.10.10.3-0.2-0.30.30.3-0.3-0.3-0.00.00.4-0.00.20.2
Bone: endosteal perimeter1.32.83.7-1.6-1.71.71.6-1.6-1.61.61.61.7-1.5-1.7-1.61.91.8
Epididymis fat weight0.31.21.41.21.2-1.1-1.11.11.1-1.1-1.1-1.01.11.11.0-1.0-1.0
Delta time in closed arm before/after self-admin0.60.50.8-0.8-0.60.70.7-0.7-0.70.70.70.8-0.9-0.6-0.90.80.8
Delta time in open arm before/after self-admin0.30.30.40.60.6-0.6-0.60.60.6-0.6-0.6-0.50.50.60.6-0.5-0.5
Diff in mean of infusions in LGA sessions0.10.10.5-0.00.00.0-0.10.10.1-0.1-0.1-0.40.70.10.7-0.2-0.6
Delay discount exponential model param1.71.92.31.51.2-1.5-1.41.41.4-1.4-1.4-1.41.41.41.4-1.3-1.3
Extinction: sum of active levers before priming0.00.00.2-0.4-0.20.30.2-0.2-0.20.10.10.1-0.1-0.2-0.20.20.1
Active lever presses in extinction session 60.00.00.10.10.3-0.2-0.30.30.3-0.3-0.3-0.10.10.2-0.00.10.3
Bone: final force1.21.93.01.31.2-1.0-1.21.21.2-1.2-1.2-1.61.71.11.7-1.4-1.7
Bone: final moment1.42.23.51.41.4-1.1-1.31.31.3-1.3-1.3-1.71.81.21.9-1.6-1.8
Food consumed during 24 hour testing period1.31.82.21.51.3-1.3-1.31.31.3-1.3-1.3-1.41.41.21.4-1.4-1.3
Glucose0.81.32.01.41.3-1.2-1.21.21.2-1.2-1.2-1.01.01.11.0-1.0-0.8
Heart weight1.82.84.71.61.6-1.4-1.51.51.5-1.5-1.5-1.82.21.42.1-1.4-1.9
Delay discount hyperbolic model param2.02.22.61.61.3-1.6-1.51.51.5-1.5-1.5-1.41.51.51.4-1.4-1.3
Intermittent access intake day 1-15 change0.81.62.1-1.2-1.21.51.2-1.2-1.21.21.21.3-1.2-1.3-1.21.31.2
Intermittent access intake escalation1.02.13.0-1.4-1.41.71.5-1.5-1.41.51.41.5-1.4-1.5-1.41.41.3
Intermittent access intake escalation 20.20.30.4-0.4-0.40.70.5-0.5-0.50.50.50.6-0.5-0.5-0.50.50.4
Intermitt. access day 1 inactive lever presses0.00.10.3-0.2-0.40.60.3-0.3-0.30.30.3-0.00.0-0.4-0.0-0.2-0.3
Intermitt. access day 15 inactive lever presses0.81.62.7-1.6-1.41.61.4-1.4-1.41.41.40.9-1.0-1.4-0.90.60.4
Intermitt. access escalation Index0.10.10.3-0.2-0.10.00.1-0.1-0.10.10.10.3-0.4-0.1-0.40.40.6
Intermittent access day 1 total infusions0.20.40.6-0.8-0.60.80.7-0.7-0.70.70.70.5-0.6-0.6-0.40.50.4
Intermittent access day 15 total infusions1.72.63.5-1.7-1.61.91.6-1.6-1.61.61.61.6-1.6-1.6-1.41.71.4
Intermittent access terminal intake (last 3 days)1.41.92.5-1.5-1.31.61.3-1.3-1.31.31.31.4-1.4-1.3-1.21.51.3
Intermittent access total infusions2.02.33.2-1.7-1.61.81.6-1.6-1.61.61.61.4-1.4-1.6-1.21.51.2
Intermittent access day 1 locomotion0.00.00.10.10.3-0.1-0.20.20.2-0.2-0.2-0.20.10.30.2-0.3-0.1
Intermittent access day 15 total locomotion0.50.91.5-0.8-0.81.00.8-0.8-0.80.80.81.1-1.2-0.8-1.21.11.2
Intermittent access total locomotion1.21.52.0-1.1-1.11.31.1-1.1-1.11.11.11.3-1.4-1.1-1.41.21.4
Intermittent access standard deviation0.00.00.2-0.1-0.00.30.0-0.0-0.00.00.0-0.20.2-0.00.3-0.4-0.5
Left kidney weight0.63.03.92.02.0-1.7-1.81.81.8-1.8-1.7-1.71.61.61.7-1.7-1.5
Right kidney weight0.31.21.61.31.2-1.2-1.11.11.1-1.1-1.1-1.01.01.01.1-1.0-0.9
Cocaine induced anxiety0.10.20.60.30.1-0.3-0.30.30.3-0.3-0.3-0.60.60.20.8-0.5-0.6
Post-drug Anxiety0.00.00.10.0-0.2-0.00.0-0.0-0.00.00.0-0.10.2-0.10.3-0.0-0.1
Baseline Anxiety0.20.20.6-0.4-0.20.30.4-0.4-0.40.40.40.6-0.6-0.3-0.70.40.5
Tail length5.120.121.54.54.6-4.5-4.54.54.5-4.5-4.5-4.54.34.64.2-4.6-4.3
Length with tail9.340.345.36.46.4-6.2-6.36.36.3-6.3-6.3-6.56.36.26.3-6.7-6.4
Length without tail7.223.225.54.94.8-4.7-4.84.84.7-4.7-4.7-4.94.94.64.9-5.1-4.9
Times rat made contact with spout0.50.61.00.90.6-0.8-0.80.80.8-0.8-0.8-0.80.90.71.0-0.5-0.7
Lifetime Intake2.32.73.4-1.7-1.61.81.7-1.7-1.71.71.71.6-1.7-1.6-1.51.61.5
Liver weight, left0.81.32.31.01.1-1.0-1.11.11.1-1.1-1.1-1.21.01.11.0-1.5-1.2
Liver weight, right1.73.05.21.61.7-1.6-1.71.71.7-1.7-1.7-1.91.51.71.5-2.3-1.9
Locomotor activity5.38.29.92.92.9-3.2-3.03.03.0-3.0-3.0-2.82.92.92.8-2.3-2.3
Locomotor testing distance4.07.38.82.63.0-2.8-2.82.82.8-2.8-2.8-2.52.62.92.6-2.3-2.3
Locomotor testing rearing0.00.10.3-0.10.3-0.3-0.30.30.3-0.3-0.4-0.10.20.60.1-0.0-0.1
Locomotion in novel chamber0.10.10.4-0.4-0.60.20.4-0.4-0.40.40.40.2-0.1-0.6-0.20.20.2
Locomotion in novel chamber post-restriction0.30.50.80.90.8-0.9-0.80.80.8-0.8-0.8-0.50.60.80.4-0.3-0.2
Fecal boli incidents, locomotor time 10.40.61.10.50.8-0.6-0.70.70.7-0.7-0.7-0.91.10.81.0-0.7-0.9
Change in fecal boli incidents, locomotor task0.00.00.1-0.10.10.20.1-0.1-0.10.10.10.1-0.2-0.1-0.3-0.10.0
Time >=10cm from walls, locomotor time 10.20.20.7-0.3-0.50.20.4-0.4-0.40.40.40.5-0.8-0.4-0.80.10.5
Bouts of movement, locomotor time 10.10.20.80.10.4-0.2-0.20.20.2-0.2-0.2-0.50.30.30.3-0.9-0.7
Total resting periods, locomotor time 10.10.10.70.10.3-0.1-0.20.20.2-0.2-0.2-0.40.20.30.2-0.8-0.6
Rest time, locomotor task time 10.30.40.8-0.9-0.30.80.8-0.8-0.80.80.80.5-0.5-0.4-0.60.10.1
Distance moved, locomotor task time 10.91.42.21.51.0-1.3-1.31.31.3-1.3-1.2-1.11.21.11.2-0.9-0.9
Vertical activity count, locomotor time 10.40.81.41.20.7-1.0-1.01.01.0-1.0-1.0-0.81.00.91.1-0.4-0.6
Time >=10cm from walls, locomotor time 21.01.51.91.31.2-1.3-1.21.21.2-1.2-1.2-1.31.21.21.1-1.4-1.2
Bouts of movement, locomotor time 20.00.00.0-0.20.00.10.1-0.1-0.10.10.10.1-0.1-0.2-0.10.20.2
Total resting periods, locomotor time 20.10.10.2-0.4-0.20.40.3-0.3-0.30.30.30.4-0.3-0.5-0.40.50.4
Rest time, locomotor task time 20.00.00.2-0.4-0.00.30.2-0.2-0.20.20.20.1-0.1-0.10.0-0.0-0.2
Distance moved, locomotor task time 20.81.01.91.40.9-1.1-1.11.11.1-1.1-1.0-1.01.01.00.7-0.9-0.6
Vertical activity count, locomotor time 20.00.00.20.4-0.1-0.2-0.20.20.2-0.2-0.20.00.00.1-0.10.20.3
Light reinforcement 10.41.01.31.11.1-1.0-1.11.11.0-1.0-1.0-1.01.11.01.1-0.6-0.7
Light reinforcement 20.10.20.5-0.1-0.20.40.3-0.3-0.30.30.30.5-0.6-0.3-0.60.50.7
Bone: marrow area0.00.10.10.10.3-0.2-0.30.30.3-0.3-0.3-0.00.10.4-0.00.10.2
Bone: maximum diameter0.30.61.0-0.9-1.01.00.9-0.9-0.90.90.90.5-0.5-1.0-0.40.50.2
Bone: maximum force0.71.21.71.01.0-0.8-1.11.11.1-1.1-1.1-1.21.21.01.3-1.2-1.3
Bone: maximum moment0.81.42.01.11.1-0.9-1.11.11.1-1.1-1.1-1.31.31.01.4-1.3-1.4
Mean time between licks in bursts0.81.92.2-1.4-1.51.41.5-1.5-1.51.51.51.3-1.4-1.5-1.41.01.1
Mean num. licks in bursts0.50.81.41.20.9-1.1-1.01.01.0-1.0-0.9-0.80.70.90.6-0.8-0.4
Cd content in liver0.10.20.4-0.2-0.40.30.3-0.3-0.30.30.40.4-0.4-0.4-0.50.50.6
Co content in liver1.11.32.0-1.4-1.31.31.2-1.2-1.21.21.20.9-0.9-1.1-1.20.80.8
Cu content in liver4.14.85.52.22.2-2.1-2.22.22.2-2.2-2.2-2.32.32.22.3-2.0-2.1
Fe content in liver1.31.62.11.01.0-1.3-1.21.21.2-1.3-1.3-1.31.41.31.3-1.2-1.3
K content in liver0.20.20.40.50.5-0.3-0.40.40.4-0.3-0.3-0.50.60.30.5-0.2-0.3
Mg content in liver1.01.01.5-0.8-0.81.21.1-1.1-1.11.11.10.7-0.7-1.2-0.81.00.9
Mn content in liver0.00.00.10.30.30.2-0.00.00.0-0.00.0-0.1-0.0-0.0-0.20.00.3
Na content in liver0.60.71.00.60.6-1.0-0.80.80.8-0.8-0.8-0.90.90.90.7-0.8-0.7
Rb content in liver0.91.02.60.40.5-1.0-0.80.90.9-0.9-0.9-1.21.01.00.9-1.6-1.6
Se content in liver0.00.10.20.40.4-0.1-0.20.20.2-0.2-0.2-0.20.30.20.2-0.0-0.0
Sr content in liver0.10.10.30.30.30.40.2-0.2-0.30.30.30.2-0.2-0.4-0.30.40.6
Zn content in liver2.12.32.81.61.5-1.4-1.51.51.5-1.5-1.4-1.71.61.41.5-1.6-1.4
Bone: minimum diameter0.50.91.6-1.1-1.01.31.0-1.0-1.01.11.00.8-0.9-1.0-1.00.40.5
Time in familiar zone, hab. session 11.11.11.9-1.4-1.31.01.1-1.1-1.11.11.10.9-1.0-0.9-1.10.70.6
Time in novel zone, hab. session 10.70.71.01.00.9-0.9-0.80.80.8-0.8-0.8-0.80.80.70.9-0.6-0.6
Total zone transitions, hab. session 10.40.51.21.01.1-0.6-0.80.80.8-0.8-0.8-0.50.60.70.5-0.2-0.0
Total locomotion distance, hab. session 10.20.30.70.80.8-0.6-0.60.60.6-0.6-0.6-0.50.50.60.5-0.4-0.3
Locomotion velocity, hab. session 10.30.40.70.80.8-0.6-0.70.70.7-0.6-0.6-0.50.50.60.5-0.3-0.2
Time in familiar zone, hab. session 20.50.61.0-1.0-0.90.90.9-0.9-0.90.90.90.3-0.4-0.8-0.5-0.0-0.1
Time in novel zone, hab. session 20.10.10.20.20.1-0.3-0.20.20.2-0.2-0.20.2-0.10.2-0.10.50.5
Total zone transitions, hab. session 20.10.10.20.50.40.0-0.20.20.2-0.1-0.10.00.10.00.20.50.4
Total locomotion distance, hab. session 20.30.40.80.90.8-0.6-0.60.60.6-0.6-0.6-0.50.60.60.7-0.2-0.2
Locomotion velocity, hab. session 20.20.30.60.80.7-0.5-0.60.60.5-0.5-0.5-0.30.50.50.6-0.0-0.1
Novel to familiar place preference ratio0.50.61.00.90.9-1.0-0.90.90.9-0.9-0.9-0.50.30.90.2-0.5-0.0
Novelty place preference0.50.61.00.90.9-1.0-0.90.90.9-0.9-0.9-0.50.20.90.2-0.50.1
Time in novel zone, NPP test0.70.81.31.01.0-1.2-1.01.01.0-1.0-1.0-0.60.41.10.3-0.7-0.2
Total zone transitions, NPP test1.92.74.62.12.1-1.5-1.71.71.7-1.7-1.6-1.61.51.51.6-1.2-1.0
Total locomotion distance, NPP test1.01.42.21.51.4-1.1-1.21.21.2-1.2-1.2-1.11.21.11.2-0.9-0.8
Locomotion velocity, NPP test1.01.42.31.51.4-1.1-1.31.31.2-1.2-1.2-1.11.21.11.3-0.8-0.7
Intraocular pressure0.91.31.81.11.1-1.4-1.21.21.2-1.3-1.3-0.91.21.31.0-0.5-0.7
Delta distance traveled before/after self-admin0.10.10.20.20.1-0.3-0.20.20.2-0.2-0.2-0.30.20.20.3-0.4-0.3
Delta ambulatory time before/after self-admin0.91.11.50.81.0-0.9-1.01.01.0-1.0-1.0-1.10.91.11.0-1.2-1.1
Parametrial fat weight0.81.83.21.81.4-1.5-1.41.41.4-1.4-1.3-1.21.21.21.2-1.1-0.9
Pavlov. Cond. lever latency4.15.25.82.12.2-2.3-2.42.42.4-2.4-2.4-2.32.32.42.2-2.1-2.0
Pavlov. Cond. magazine entry latency7.49.510.6-3.1-3.23.33.2-3.2-3.23.23.23.0-2.9-3.3-2.92.82.6
Pavlov. Cond. change in total contacts1.41.52.1-1.4-1.51.21.4-1.4-1.31.31.31.1-1.1-1.3-1.20.80.7
Pavlov. Cond. index score6.27.88.8-2.8-2.92.92.9-2.9-2.92.92.92.7-2.6-3.0-2.52.62.3
Pavlov. Cond. latency score6.07.68.5-2.7-2.82.92.9-2.9-2.92.92.92.7-2.7-2.9-2.62.62.3
Pavlov. Cond. lever contacts2.42.83.4-1.5-1.71.81.8-1.8-1.81.81.81.6-1.6-1.9-1.51.51.4
Pavlov. Cond. magazine entry number7.59.410.73.23.3-3.2-3.23.23.2-3.2-3.2-3.02.93.22.8-2.9-2.5
Pavlov. Cond. intertrial magazine entries0.40.50.70.60.8-0.7-0.70.70.7-0.7-0.7-0.70.70.90.6-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.5.56.77.8-2.6-2.72.72.7-2.7-2.72.72.72.5-2.4-2.8-2.32.42.1
Pavlov. Cond. response bias6.68.29.4-2.8-3.03.03.0-3.0-3.03.03.02.8-2.7-3.1-2.52.72.3
Pavlov. Cond. lever latency0.50.71.1-0.9-1.10.80.9-0.9-0.80.80.80.7-0.8-0.8-0.70.60.6
Pavlov. Cond. magazine entry latency0.20.20.6-0.3-0.20.50.4-0.4-0.50.50.50.5-0.3-0.5-0.40.70.6
Pavlov. Cond. change in total contacts2.13.43.91.82.0-1.8-1.81.81.8-1.8-1.8-2.01.91.81.8-1.9-1.8
Pavlov. Cond. index score0.10.20.40.50.6-0.4-0.40.40.4-0.4-0.4-0.40.50.40.4-0.2-0.3
Pavlov. Cond. latency score0.10.10.20.40.5-0.2-0.30.30.2-0.2-0.2-0.30.30.20.3-0.1-0.1
Pavlov. Cond. lever contacts0.71.01.51.11.2-1.0-1.11.11.1-1.0-1.0-0.90.91.00.9-0.8-0.7
Pavlov. Cond. magazine entry number0.30.30.70.40.4-0.5-0.50.50.6-0.6-0.6-0.60.40.60.4-0.8-0.7
Pavlov. Cond. intertrial magazine entries0.50.71.2-1.1-1.10.90.9-0.9-0.90.80.80.8-0.9-0.8-0.90.50.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.40.6-0.3-0.30.30.3-0.3-0.3-0.30.40.30.4-0.1-0.2
Pavlov. Cond. response bias0.00.00.20.30.4-0.2-0.20.20.2-0.2-0.2-0.10.20.20.20.10.0
Time in closed arm before self-admin0.70.91.31.10.9-1.0-1.01.01.0-1.0-1.0-0.90.90.90.7-0.8-0.6
Time in closed arm after self-admin0.20.20.3-0.4-0.50.40.5-0.5-0.50.50.50.5-0.4-0.5-0.50.50.5
Time in open arm before self-admin0.80.81.5-1.2-0.91.01.0-1.0-1.01.01.00.7-0.9-0.9-0.80.50.5
Time in open arm after self-admin0.20.30.6-0.5-0.40.50.4-0.4-0.40.40.40.6-0.8-0.4-0.70.50.6
Bone: periosteal estimation0.00.00.1-0.1-0.00.20.0-0.0-0.00.00.0-0.20.10.00.1-0.2-0.3
Bone: periosteal perimeter1.01.82.3-1.4-1.51.51.4-1.4-1.41.41.41.2-1.2-1.4-1.21.21.1
Bone: post-yield work0.00.10.40.10.00.1-0.10.10.1-0.1-0.00.3-0.10.10.00.70.5
Progressive ratio test 1 active lever presses0.10.10.3-0.3-0.10.20.1-0.1-0.10.10.10.3-0.4-0.1-0.40.40.5
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.10.30.1-0.1-0.10.10.10.3-0.4-0.1-0.40.40.5
Progressive ratio test 1 inactive lever presses0.30.51.0-0.8-0.71.00.7-0.7-0.70.70.70.5-0.5-0.7-0.40.40.2
Progressive ratio test 2 active lever presses2.02.43.3-1.5-1.81.81.6-1.6-1.71.61.71.4-1.3-1.8-1.21.31.1
Progressive ratio test 2 breakpoint2.12.43.3-1.5-1.81.81.7-1.7-1.71.61.71.3-1.3-1.8-1.21.31.1
Progressive ratio test 2 inactive lever presses2.13.44.6-2.2-2.12.12.0-2.0-2.02.02.01.5-1.4-2.0-1.31.51.1
Incentive Sensitization - Responses1.72.53.8-1.6-1.81.91.8-1.8-1.81.71.81.2-1.2-1.8-1.11.10.7
Incentive Sensitization - Breakpoint1.92.53.8-1.7-1.82.01.8-1.8-1.81.81.81.3-1.2-1.8-1.11.10.7
Sum of active levers in priming session hrs 5-60.00.00.10.00.00.0-0.10.10.1-0.1-0.10.1-0.00.1-0.10.30.4
Progressive ratio2.33.64.31.81.9-1.9-1.91.91.9-1.9-1.9-2.12.11.71.9-2.0-1.8
Food seeking constrained by brief footshock1.11.32.1-1.0-1.31.01.2-1.2-1.21.21.21.0-1.2-1.4-1.30.60.8
Seeking ratio, punishment vs. effort4.26.17.1-2.3-2.72.42.6-2.6-2.62.62.62.5-2.5-2.6-2.42.12.0
Retroperitoneal fat weight1.56.68.62.92.7-2.7-2.72.72.6-2.6-2.6-2.42.42.62.3-2.4-2.1
Reaction time number correct0.30.50.8-0.8-0.90.40.8-0.8-0.80.80.80.7-0.8-0.8-0.90.30.3
Reaction time mean minus median0.00.10.10.30.3-0.1-0.30.30.3-0.3-0.3-0.30.20.10.3-0.4-0.3
Reaction time mean minus median AUC0.10.30.50.40.6-0.4-0.60.60.6-0.5-0.6-0.60.40.50.5-0.7-0.5
Reaction time num false alarms0.30.40.6-0.8-0.70.80.6-0.6-0.60.50.50.6-0.6-0.5-0.60.70.6
Reaction time num false alarms AUC0.10.10.2-0.4-0.40.40.3-0.3-0.30.20.20.4-0.4-0.2-0.40.40.5
Reaction time trials correct on left0.30.50.8-0.8-0.90.40.8-0.8-0.80.80.80.7-0.8-0.8-0.90.30.3
Reaction time trials on left0.30.60.9-0.8-0.90.40.8-0.8-0.80.80.80.7-0.8-0.8-0.90.30.4
Reaction time mean0.00.00.10.00.1-0.1-0.10.10.1-0.1-0.10.1-0.20.2-0.30.20.4
Reaction time mean AUC0.00.00.2-0.1-0.00.0-0.00.00.0-0.0-0.00.2-0.30.1-0.40.20.4
Median of all reaction times0.10.10.4-0.2-0.10.10.1-0.1-0.10.10.10.3-0.40.1-0.60.40.6
Reaction time omissions0.10.10.3-0.4-0.50.10.2-0.2-0.20.20.20.4-0.5-0.3-0.60.50.6
Reaction time false alarm rate0.00.00.1-0.2-0.20.40.0-0.0-0.00.00.00.2-0.10.0-0.10.40.3
Reaction time premature initiation rate2.23.03.51.81.7-1.7-1.91.91.9-1.9-1.9-1.71.71.71.6-1.5-1.3
Reaction time premature initiations0.81.41.81.21.1-1.3-1.31.31.3-1.3-1.3-1.21.21.11.0-1.2-0.9
Std. dev. reaction times0.10.10.20.40.3-0.4-0.40.40.4-0.4-0.4-0.20.10.30.1-0.20.1
Reaction time trials completed0.30.60.9-0.8-0.90.40.8-0.8-0.80.80.80.7-0.8-0.8-0.90.30.4
Reaction time trials AUC0.40.71.1-0.9-1.00.50.9-0.9-0.90.90.90.8-0.9-0.9-1.00.40.4
Run reversals in cocaine runway, females1.21.22.2-1.0-1.00.81.1-1.1-1.11.11.11.3-1.3-1.0-1.50.91.1
Run reversals in cocaine runway, males1.21.31.81.01.0-1.0-1.01.01.0-1.0-1.0-1.31.30.91.3-1.2-1.2
Latency to leave start box in cocaine runway0.40.51.00.70.6-0.6-0.50.50.5-0.5-0.5-0.80.90.41.0-0.7-1.0
Latency to leave start box in cocaine runway, F0.80.91.71.10.8-1.0-0.90.90.9-0.9-0.9-1.01.20.81.3-0.7-1.1
Latency to leave start box in cocaine runway, M0.40.40.7-0.7-0.50.60.8-0.8-0.80.80.80.3-0.4-0.9-0.40.10.1
Std. dev. time between licks in bursts3.95.46.7-2.6-2.42.52.5-2.5-2.52.52.42.2-2.1-2.4-2.12.01.7
Total sessions with >9 infusions0.50.61.0-0.7-0.91.00.9-0.9-0.90.80.90.5-0.5-0.9-0.40.50.2
Short access day 1 total inactive lever presses3.95.16.0-2.3-2.22.42.3-2.3-2.32.32.32.3-2.3-2.2-2.42.01.9
Short access day 10 total inactive lever presses0.20.62.30.40.3-0.1-0.30.30.3-0.3-0.3-1.01.00.31.0-1.3-1.5
Short access day 1 total infusions2.83.74.7-2.1-2.02.22.0-2.0-2.02.02.01.8-1.9-2.0-1.91.51.5
Short access day 10 total infusions2.43.13.6-1.8-1.71.81.8-1.8-1.81.81.81.7-1.9-1.7-1.81.51.6
Short access total infusions3.64.65.3-2.1-2.12.22.1-2.1-2.12.12.12.2-2.3-2.1-2.32.02.1
Short access day 1 locomotion0.50.61.0-0.8-0.91.00.9-0.9-0.90.90.90.6-0.5-0.9-0.50.70.5
Short access day 10 total locomotion0.00.00.10.20.1-0.1-0.10.10.1-0.1-0.1-0.0-0.30.1-0.4-0.30.2
Short access total locomotion0.10.10.2-0.2-0.30.30.2-0.2-0.30.20.30.3-0.3-0.3-0.30.40.5
One hour access (0.3 mA shock)0.81.01.6-1.0-0.91.10.9-0.9-0.90.90.91.0-1.3-0.9-1.30.61.0
Compulsive drug intake0.81.02.4-1.0-0.70.80.9-0.9-0.90.90.91.0-1.3-0.8-1.60.51.0
One hour access (shock baseline)0.40.50.8-0.8-0.90.90.8-0.8-0.80.80.80.6-0.6-0.8-0.40.80.6
Social response proportion0.20.30.50.40.4-0.7-0.60.60.6-0.6-0.6-0.40.40.50.3-0.5-0.3
Social responses0.30.30.50.50.5-0.7-0.70.70.7-0.7-0.7-0.50.50.60.6-0.3-0.3
Social time0.30.40.7-0.8-0.50.70.7-0.7-0.70.70.70.6-0.5-0.6-0.50.50.3
Soleus weight4.011.713.33.63.6-3.3-3.43.43.4-3.4-3.4-3.43.53.33.6-3.1-3.2
Bone: stiffness0.20.30.80.40.4-0.3-0.50.50.5-0.5-0.5-0.70.60.40.6-0.9-0.8
Tibialis anterior weight0.00.00.30.20.20.0-0.10.10.1-0.1-0.1-0.00.30.00.50.3-0.1
Time to tail flick, vehicle, before self-admin1.91.93.21.41.6-1.3-1.41.41.4-1.4-1.4-1.41.21.51.0-1.8-1.3
Time to tail flick, vehicle, after self-admin0.20.30.60.70.3-0.6-0.50.50.5-0.5-0.5-0.50.70.40.8-0.1-0.2
Time to tail flick, test, before self-admin0.00.00.30.2-0.0-0.1-0.00.00.0-0.0-0.00.2-0.20.1-0.00.50.5
Time to tail flick, test, after self-admin0.10.10.2-0.3-0.30.30.4-0.4-0.40.40.40.2-0.2-0.3-0.20.20.1
Delta time to tail flick, vehicle, before/after SA0.40.40.9-0.5-1.00.60.6-0.6-0.70.60.70.5-0.3-0.8-0.11.00.6
Delta time to tail flick, test, before/after SA0.20.20.4-0.6-0.40.50.5-0.5-0.50.50.50.3-0.4-0.5-0.50.20.2
Tibia length6.317.420.44.54.4-3.9-4.24.24.1-4.1-4.1-4.34.24.04.3-4.2-3.9
Ambulatory time before self-admin0.61.01.3-1.1-0.90.81.0-1.0-1.01.01.01.0-0.8-1.0-1.01.21.0
Ambulatory time after self-admin0.00.00.2-0.4-0.10.10.2-0.2-0.10.20.10.2-0.2-0.1-0.20.30.2
Bone: tissue strength3.53.54.61.71.8-1.7-1.81.81.8-1.8-1.8-2.02.01.81.9-2.1-2.1
Total heroin consumption1.92.22.91.21.4-1.5-1.51.51.5-1.5-1.5-1.51.71.61.7-1.3-1.6
Bone: trabecular number0.91.63.2-1.0-1.01.01.0-1.0-1.01.01.01.5-1.6-0.9-1.61.51.8
Bone: trabecular spacing2.22.95.41.31.5-1.3-1.41.41.4-1.4-1.5-2.02.01.52.0-2.1-2.3
Bone: trabecular thickness0.10.10.40.40.3-0.2-0.20.20.2-0.2-0.20.2-0.30.1-0.20.30.6
Bone: trabecular tissue density0.40.60.80.80.8-0.7-0.80.80.7-0.7-0.7-0.90.80.70.9-0.9-0.8
Water consumed over 24 hours0.10.10.40.30.1-0.1-0.10.10.1-0.1-0.1-0.50.50.10.6-0.5-0.6
Number of responses in last shaping day0.20.30.8-0.8-0.50.90.6-0.6-0.50.50.50.2-0.1-0.5-0.00.1-0.1