Hub : Genes

Slit2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr14_66921777_66926033 0.03 0.02 1.0e-03 0.01 0.02 0.01 0.01 4.3e-02 2.9e-03 1.1e-02 7.8e-03
2 PL intron excision ratio chr14_66921777_66925148 0.03 0.02 1.9e-04 0.01 0.03 0.02 0.02 8.8e-03 4.2e-04 1.1e-03 2.5e-03
3 OFC intron excision ratio chr14_66921777_66926033 0.12 0.09 8.4e-03 0.02 0.02 -0.01 0 9.0e-02 1.2e-01 9.0e-01 2.7e-01
4 NAcc gene expression Slit2 0.26 0.08 0.0e+00 0.12 0.14 0.13 0.15 5.3e-17 2.0e-20 1.6e-19 1.4e-21
5 Liver gene expression Slit2 0.06 0.03 1.0e-05 0.04 0.04 0.04 0.04 2.3e-05 1.9e-05 4.9e-05 2.0e-05
6 LHb gene expression Slit2 0.44 0.15 1.3e-03 0.1 0.03 0.14 0.08 2.7e-03 8.5e-02 3.4e-04 6.8e-03
7 RMTg isoform ratio NM_022632.2 0.48 0.21 5.0e-03 -0 0.01 0.03 0.05 4.3e-01 1.5e-01 5.6e-02 1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.20.31.00.1-0.00.1-0.50.9-1.00.2
Area under the delay curve1.11.32.01.4-1.41.30.71.3-1.0-0.1
BMI with tail1.13.98.7-2.72.8-3.0-1.0-1.10.9-0.9
BMI without tail1.54.68.6-2.42.5-2.90.2-1.72.1-2.0
Body weight3.816.531.7-5.55.5-5.6-2.3-2.82.4-2.2
Weight adjusted by age1.52.34.7-1.81.9-1.7-2.20.2-1.30.6
Bone surface0.71.32.3-1.41.5-1.5-1.40.5-0.60.3
Bone volume0.30.51.1-0.40.5-0.6-0.71.1-1.00.2
Breakpoint value in progressive ratio session0.81.02.61.2-1.10.60.81.6-0.4-0.7
Number of licking bursts0.91.54.11.6-1.62.00.9-0.2-0.20.3
Context. condit. distance diff. score1.41.75.9-0.30.3-0.0-1.81.4-2.40.9
Locomotion velocity, session 10.50.61.80.2-0.30.00.9-0.71.3-0.8
Locomotion distance, session 11.01.32.31.5-1.51.41.40.20.4-0.1
Locomotion velocity, session 20.50.61.21.1-1.10.90.50.7-0.30.2
Locomotion distance, session 20.20.30.50.7-0.70.60.70.30.10.0
Locomotion velocity, session 30.20.20.5-0.50.5-0.5-0.6-0.20.0-0.7
Locomotion distance, session 34.44.79.1-3.03.0-2.5-2.8-0.9-0.6-0.3
Stereotopy head waving bouts, day 30.81.02.01.4-1.41.31.00.40.20.2
Stereotopy head waving duration, day 32.02.44.62.1-2.12.11.70.00.70.6
Locomotion velocity, session 70.80.83.90.4-0.50.40.9-0.50.4-2.0
Locomotion distance, session 70.50.71.0-1.01.0-0.7-0.8-0.6-0.2-1.0
Stereotopy head waving bouts, day 70.80.92.60.8-0.70.5-0.11.4-1.6-0.5
Stereotopy head waving duration, day 70.70.81.61.1-1.00.70.51.3-1.1-0.2
Locomotion velocity, session 80.30.30.70.3-0.30.6-0.50.6-0.80.8
Locomotion distance, session 80.40.62.10.4-0.30.4-0.61.0-1.50.1
Degree of sensitization distance2.12.23.81.9-1.91.72.00.20.7-0.4
Degree of sensitization stereotypy0.80.92.40.5-0.40.0-0.11.4-1.5-1.2
Conditioned locomotion1.92.24.81.4-1.51.12.2-0.71.4-1.7
Cocaine response after cond. corrected0.10.10.4-0.10.00.3-0.1-0.60.20.4
Cocaine response after cond. not corrected0.10.10.8-0.10.10.20.1-0.90.30.2
Cocaine response before conditioning0.20.20.7-0.50.5-0.8-0.2-0.1-0.2-0.6
Saline control response0.50.61.4-0.80.8-0.7-1.20.4-0.90.3
Bone: connectivity density0.81.22.3-1.51.5-1.3-1.4-0.1-0.3-0.1
Bone: cortical apparent density1.41.96.0-1.81.9-2.4-0.70.10.3-0.3
Bone: cortical area1.62.54.8-2.22.2-2.1-1.4-1.10.50.2
Bone: cortical porosity1.51.65.7-1.31.2-0.5-0.6-2.41.4-0.1
Bone: cortical porosity0.91.03.1-1.11.0-0.3-0.9-1.80.70.4
Bone: cortical thickness0.30.61.4-0.80.8-0.5-0.5-1.20.60.8
Bone: cortical thickness0.60.71.5-0.40.5-0.4-1.11.1-1.20.6
Bone: cortical tissue density1.41.95.6-1.81.9-2.4-0.7-0.10.4-0.2
Condit. Reinf. active minus inactive responses0.30.41.0-0.60.6-0.5-1.00.1-0.50.5
Condit. Reinf. active-inactive response ratio0.50.51.4-0.70.7-0.7-1.20.4-0.60.5
Condit. Reinf. active responses0.00.00.1-0.10.2-0.2-0.20.1-0.3-0.2
Condit. Reinf. inactive responses1.01.22.80.8-0.90.71.7-0.50.9-1.6
Incentive salience index mean0.70.91.7-1.11.2-1.1-1.30.3-0.60.4
Condit. Reinf. lever presses1.41.93.9-2.02.0-1.9-1.3-0.30.10.5
Condit. Reinf. active minus inactive responses0.30.40.7-0.70.7-0.7-0.80.0-0.50.2
Condit. Reinf. active-inactive response ratio0.10.20.40.3-0.30.10.5-0.10.5-0.6
Condit. Reinf. active responses0.60.92.0-1.01.0-0.8-1.40.1-1.00.7
Condit. Reinf. inactive responses0.60.81.8-0.80.8-0.7-1.20.5-1.30.4
Condit. Reinf. lever presses0.71.02.1-1.01.0-0.9-1.50.3-1.01.0
Condit. Reinf. lever reinforcers received0.60.92.1-0.70.7-0.5-1.50.4-1.31.0
Conditioned reinforcement - actives0.50.81.80.5-0.60.61.0-1.31.3-0.3
Conditioned reinforcement - inactives1.62.34.92.0-2.12.21.6-0.10.7-0.0
Conditioned locomotion1.62.16.50.2-0.30.01.9-1.92.6-1.0
Patch foraging indifference point 0 sec0.10.30.8-0.10.00.10.5-0.90.7-0.4
Patch foraging indifference point AUC0.30.40.80.8-0.80.70.90.00.1-0.6
Delay disc. indifference point, 0s delay1.21.32.31.4-1.40.91.51.10.0-0.9
Delay disc. indifference point, 16s delay1.21.32.11.4-1.41.40.31.3-1.3-0.1
Delay disc. indifference point, 2s delay1.21.32.71.5-1.51.61.3-0.10.2-0.0
Delay disc. indifference point, 24s delay1.71.94.61.8-1.82.10.50.7-1.00.3
Delay disc. indifference point, 4s delay0.70.72.01.0-0.90.31.01.4-0.3-0.5
Delay disc. indifference point, 8s delay0.40.41.50.2-0.20.2-0.41.1-1.20.4
Indifference point function ln k0.20.31.5-0.1-0.00.40.2-1.20.90.0
Indifference point function log k0.20.31.5-0.1-0.00.40.2-1.20.90.0
Patch foraging total patch changes 0 sec0.10.20.70.1-0.10.10.6-0.80.6-0.5
Patch foraging total patch changes 12 sec0.70.82.20.9-0.90.61.5-0.50.9-0.9
Patch foraging total patch changes 18 sec0.10.20.40.2-0.2-0.20.50.5-0.4-0.7
Patch foraging total patch changes 24 sec0.30.41.4-0.40.4-0.30.3-0.70.8-1.2
Patch foraging total patch changes 6 sec0.71.02.60.5-0.50.31.6-1.01.4-1.0
Patch foraging time to switch 0 sec0.40.93.0-1.01.1-1.7-0.50.8-0.2-0.2
Patch foraging water rate 0 sec0.20.31.20.1-0.20.80.1-1.10.50.2
Patch foraging water rate 12 sec0.10.30.50.2-0.20.6-0.50.4-0.6-0.7
Patch foraging water rate 18 sec0.50.71.6-1.00.9-0.3-1.0-1.30.60.6
Patch foraging water rate 24 sec0.20.31.2-0.30.20.4-0.7-0.3-0.11.1
Patch foraging water rate 6 sec0.10.10.40.5-0.40.20.60.30.3-0.1
Seeking ratio, delayed vs. immediate footshock0.20.30.9-0.60.6-0.9-0.4-0.0-0.1-0.1
Distance traveled before self-admin1.01.22.90.5-0.50.21.7-0.91.5-1.4
Distance traveled after self-admin0.60.73.10.1-0.1-0.30.9-0.10.8-1.8
Extensor digitorum longus weight1.66.312.1-3.23.2-3.5-1.1-2.12.1-1.4
Bone: elastic displacement0.20.20.40.5-0.50.60.5-0.30.5-0.0
Bone: elastic work1.21.62.3-1.51.5-0.8-1.1-1.50.81.4
Bone: endosteal estimation1.94.29.5-2.62.8-3.1-2.10.6-0.60.1
Bone: endosteal perimeter1.73.68.3-2.42.5-2.9-1.80.4-0.9-0.5
Epididymis fat weight1.86.212.3-3.43.4-3.5-1.4-1.31.4-1.4
Delta time in closed arm before/after self-admin1.91.84.1-1.11.1-1.40.5-1.31.5-2.0
Delta time in open arm before/after self-admin1.11.13.40.5-0.40.2-0.61.7-1.90.6
Diff in mean of infusions in LGA sessions1.41.63.11.3-1.41.71.4-1.11.4-0.1
Delay discount exponential model param0.91.01.7-1.31.3-1.3-0.7-0.90.80.1
Extinction: sum of active levers before priming1.11.23.41.1-1.10.51.01.1-0.5-1.8
Active lever presses in extinction session 61.71.73.11.8-1.71.41.51.10.2-0.4
Bone: final force1.72.75.3-2.22.2-2.3-0.8-1.11.30.0
Bone: final moment1.82.95.8-2.32.4-2.4-1.0-1.11.10.4
Food consumed during 24 hour testing period0.91.22.5-1.61.5-1.3-1.2-0.90.00.1
Glucose1.42.15.9-0.1-0.00.11.4-2.12.4-1.7
Heart weight3.25.09.7-3.13.1-2.9-1.8-1.90.80.4
Delay discount hyperbolic model param1.01.11.9-1.41.4-1.3-0.9-0.90.60.1
Intermittent access intake day 1-15 change1.94.08.6-2.42.3-1.5-1.0-2.91.81.0
Intermittent access intake escalation1.83.79.5-2.22.0-1.4-0.5-3.12.20.6
Intermittent access intake escalation 24.24.88.5-2.72.6-1.5-1.7-2.91.51.9
Intermitt. access day 1 inactive lever presses0.10.41.00.2-0.1-0.3-0.11.0-1.0-0.8
Intermitt. access day 15 inactive lever presses0.10.21.1-0.30.3-0.1-0.4-0.20.01.1
Intermitt. access escalation Index1.82.64.52.1-2.11.91.60.9-0.3-1.5
Intermittent access day 1 total infusions0.30.50.80.9-0.90.60.70.6-0.1-0.7
Intermittent access day 15 total infusions0.91.44.1-0.80.7-0.60.6-2.01.9-0.7
Intermittent access terminal intake (last 3 days)0.50.73.0-0.60.5-0.10.0-1.71.2-0.1
Intermittent access total infusions0.80.92.90.2-0.20.21.1-1.11.7-1.1
Intermittent access day 1 locomotion1.92.55.91.5-1.50.72.40.41.6-2.0
Intermittent access day 15 total locomotion0.30.51.4-0.40.4-0.70.5-0.61.2-0.6
Intermittent access total locomotion1.31.55.1-0.30.3-0.71.3-1.32.3-1.3
Intermittent access standard deviation2.96.110.0-3.23.0-2.1-2.0-3.01.61.8
Left kidney weight0.94.39.3-1.91.8-1.80.5-3.03.1-1.0
Right kidney weight0.94.110.6-1.51.4-1.31.1-3.23.3-0.9
Cocaine induced anxiety1.52.13.41.5-1.61.71.8-0.71.5-0.9
Post-drug Anxiety0.50.50.90.7-0.70.90.8-0.50.8-0.2
Baseline Anxiety1.01.11.9-1.31.4-1.4-1.2-0.1-0.80.3
Tail length0.93.75.8-2.42.4-2.4-0.7-1.71.5-1.8
Length with tail1.77.513.7-3.73.7-3.4-2.0-2.31.6-1.3
Length without tail1.13.66.8-2.62.5-1.9-2.0-1.90.70.6
Times rat made contact with spout0.30.31.50.3-0.30.70.0-0.10.11.2
Lifetime Intake1.11.33.90.4-0.40.21.5-1.02.0-1.4
Liver weight, left2.54.27.2-2.72.7-2.5-0.9-2.21.7-0.5
Liver weight, right0.50.92.0-1.21.3-1.4-0.0-0.40.8-0.8
Locomotor activity1.21.93.9-1.61.7-2.0-0.9-0.3-0.1-1.8
Locomotor testing distance0.50.92.3-0.90.9-0.7-1.30.7-1.5-0.0
Locomotor testing rearing0.10.30.70.3-0.30.6-0.20.6-0.90.2
Locomotion in novel chamber0.40.51.9-0.20.10.50.0-1.41.0-0.2
Locomotion in novel chamber post-restriction0.40.61.8-0.70.6-0.40.1-1.31.20.1
Fecal boli incidents, locomotor time 10.30.41.4-0.20.10.5-0.8-0.6-0.51.2
Change in fecal boli incidents, locomotor task0.70.72.3-0.40.5-1.2-0.31.5-0.7-0.4
Time >=10cm from walls, locomotor time 10.50.51.3-0.50.6-1.1-0.00.8-0.2-1.0
Bouts of movement, locomotor time 10.60.72.2-0.70.7-0.50.1-1.51.2-0.1
Total resting periods, locomotor time 10.70.82.0-1.01.0-0.7-0.3-1.41.00.4
Rest time, locomotor task time 13.13.86.9-2.62.6-2.1-1.7-1.70.91.4
Distance moved, locomotor task time 11.01.64.41.0-0.9-0.31.71.40.3-2.1
Vertical activity count, locomotor time 11.43.35.82.2-2.21.32.41.10.3-2.1
Time >=10cm from walls, locomotor time 20.60.91.9-0.60.7-1.40.8-0.31.4-1.1
Bouts of movement, locomotor time 20.61.02.4-1.11.0-0.6-0.9-1.60.40.7
Total resting periods, locomotor time 20.61.12.4-1.31.2-0.8-1.0-1.50.50.6
Rest time, locomotor task time 21.82.34.2-2.12.1-1.9-1.6-0.70.20.9
Distance moved, locomotor task time 21.41.63.81.1-1.10.32.00.21.2-1.9
Vertical activity count, locomotor time 21.72.34.02.0-2.01.82.0-0.20.8-0.8
Light reinforcement 10.71.73.5-1.51.4-0.5-1.2-1.90.51.6
Light reinforcement 20.40.71.1-1.00.9-0.8-0.7-0.90.21.0
Bone: marrow area1.94.29.6-2.62.7-3.1-2.10.6-0.70.1
Bone: maximum diameter1.01.93.6-1.71.7-1.9-0.5-1.30.9-1.0
Bone: maximum force2.23.97.5-2.72.7-2.7-2.2-0.2-0.40.8
Bone: maximum moment2.54.48.0-2.82.8-2.8-2.4-0.2-0.51.1
Mean time between licks in bursts1.02.34.32.1-2.11.91.11.3-1.1-0.6
Mean num. licks in bursts1.11.73.8-1.71.8-1.9-1.20.10.10.6
Cd content in liver1.01.14.5-0.10.00.7-1.3-0.2-0.92.1
Co content in liver3.84.411.0-2.52.3-1.3-3.3-1.4-0.91.9
Cu content in liver0.40.41.5-0.30.4-0.8-0.31.2-0.5-0.5
Fe content in liver0.50.62.2-0.50.5-0.2-1.00.2-0.61.5
K content in liver0.70.71.4-0.70.7-0.9-0.0-1.00.8-1.2
Mg content in liver0.30.30.60.4-0.40.20.8-0.60.6-0.7
Mn content in liver0.50.52.00.5-0.40.20.90.20.4-1.4
Na content in liver0.10.10.3-0.00.1-0.20.00.20.2-0.5
Rb content in liver0.60.71.90.2-0.30.10.9-1.21.4-0.9
Se content in liver0.30.41.20.7-0.70.41.10.40.0-0.0
Sr content in liver0.20.20.50.4-0.40.5-0.00.3-0.20.7
Zn content in liver0.20.30.4-0.70.6-0.4-0.6-0.50.10.2
Bone: minimum diameter1.42.55.1-2.12.1-2.3-1.7-0.3-0.3-0.6
Time in familiar zone, hab. session 10.70.72.9-0.30.3-0.1-0.90.3-0.81.7
Time in novel zone, hab. session 10.50.51.90.0-0.0-0.10.6-0.61.0-1.4
Total zone transitions, hab. session 10.10.20.40.1-0.20.30.3-0.60.6-0.5
Total locomotion distance, hab. session 10.20.20.50.1-0.10.6-0.7-0.2-0.70.5
Locomotion velocity, hab. session 10.20.30.90.4-0.41.0-0.4-0.1-0.60.7
Time in familiar zone, hab. session 21.11.12.71.0-1.11.6-0.20.0-0.71.7
Time in novel zone, hab. session 21.01.02.4-1.11.2-1.6-0.0-0.10.8-1.2
Total zone transitions, hab. session 20.40.51.60.5-0.4-0.11.00.50.6-1.3
Total locomotion distance, hab. session 20.30.40.80.5-0.50.50.9-0.40.9-0.6
Locomotion velocity, hab. session 20.40.51.00.5-0.50.41.0-0.51.0-0.7
Novel to familiar place preference ratio0.70.81.30.9-1.01.10.9-0.40.4-1.1
Novelty place preference0.70.71.40.9-1.01.10.8-0.20.3-1.2
Time in novel zone, NPP test0.70.71.30.9-1.01.10.7-0.10.2-1.2
Total zone transitions, NPP test0.10.10.30.5-0.50.30.50.30.4-0.0
Total locomotion distance, NPP test0.50.61.6-0.30.30.1-1.20.4-1.01.3
Locomotion velocity, NPP test0.30.41.3-0.20.10.3-1.00.3-0.81.1
Intraocular pressure0.20.20.9-0.20.20.2-0.4-0.1-0.61.0
Delta distance traveled before/after self-admin0.20.20.7-0.10.1-0.3-0.20.6-0.3-0.9
Delta ambulatory time before/after self-admin0.10.10.3-0.20.2-0.3-0.20.1-0.0-0.6
Parametrial fat weight1.02.36.91.0-1.00.52.6-1.02.0-1.4
Pavlov. Cond. lever latency0.81.01.61.1-1.11.10.11.2-1.3-0.1
Pavlov. Cond. magazine entry latency0.70.92.2-0.90.8-0.3-0.4-1.51.01.1
Pavlov. Cond. change in total contacts0.30.30.6-0.70.7-0.6-0.6-0.3-0.10.4
Pavlov. Cond. index score1.01.32.1-1.51.4-1.2-0.7-1.21.00.8
Pavlov. Cond. latency score0.91.21.9-1.31.2-1.1-0.3-1.41.30.7
Pavlov. Cond. lever contacts1.01.12.4-1.51.5-1.5-0.7-0.60.60.1
Pavlov. Cond. magazine entry number0.60.81.41.0-0.90.50.61.2-0.6-1.0
Pavlov. Cond. intertrial magazine entries0.70.92.80.8-0.70.40.21.7-1.3-0.7
Pavlov. Cond. lever-magazine prob. diff.1.31.62.7-1.61.6-1.4-0.9-1.20.80.9
Pavlov. Cond. response bias0.91.12.0-1.41.4-1.1-0.8-1.10.60.9
Pavlov. Cond. lever latency1.21.62.51.1-1.21.41.6-1.31.6-0.5
Pavlov. Cond. magazine entry latency0.50.62.40.2-0.20.6-0.80.2-1.01.6
Pavlov. Cond. change in total contacts0.40.71.9-0.40.4-0.8-0.91.4-1.1-0.2
Pavlov. Cond. index score0.91.23.2-0.20.2-0.3-1.31.4-1.81.0
Pavlov. Cond. latency score1.01.33.8-0.20.2-0.3-1.41.5-1.90.9
Pavlov. Cond. lever contacts1.11.52.4-1.11.2-1.5-1.51.1-1.40.4
Pavlov. Cond. magazine entry number0.70.92.0-0.90.9-0.90.2-1.41.3-0.5
Pavlov. Cond. intertrial magazine entries2.23.37.12.1-2.11.72.7-0.31.0-1.8
Pavlov. Cond. lever-magazine prob. diff.0.91.23.3-0.00.1-0.0-1.31.3-1.81.3
Pavlov. Cond. response bias0.70.92.3-0.30.4-0.6-1.11.3-1.50.7
Time in closed arm before self-admin0.10.10.8-0.20.20.1-0.2-0.20.10.9
Time in closed arm after self-admin1.41.54.5-1.41.3-0.8-0.3-2.11.5-0.0
Time in open arm before self-admin0.40.41.2-0.40.4-0.70.3-0.50.7-1.1
Time in open arm after self-admin1.41.65.90.5-0.3-0.5-0.22.4-2.0-0.6
Bone: periosteal estimation2.65.411.2-3.23.3-3.4-2.4-0.4-0.20.3
Bone: periosteal perimeter1.93.26.6-2.42.5-2.6-1.8-0.3-0.5-0.2
Bone: post-yield work2.84.112.0-0.40.5-0.6-2.42.8-3.51.5
Progressive ratio test 1 active lever presses1.41.73.11.2-1.20.91.7-0.41.4-1.8
Progressive ratio test 1 breakpoint1.51.83.31.2-1.21.01.8-0.41.4-1.8
Progressive ratio test 1 inactive lever presses0.91.33.80.6-0.5-0.41.60.71.2-1.9
Progressive ratio test 2 active lever presses0.91.02.60.8-0.70.31.6-0.51.4-1.0
Progressive ratio test 2 breakpoint0.91.12.70.8-0.80.31.6-0.51.4-1.1
Progressive ratio test 2 inactive lever presses0.30.51.70.5-0.50.30.9-0.31.3-0.3
Incentive Sensitization - Responses0.30.41.20.5-0.50.01.1-0.40.8-0.7
Incentive Sensitization - Breakpoint0.20.30.90.4-0.4-0.11.0-0.30.7-0.7
Sum of active levers in priming session hrs 5-62.22.14.31.9-1.81.21.12.1-0.7-0.2
Progressive ratio0.30.51.30.7-0.60.4-0.01.2-1.0-0.4
Food seeking constrained by brief footshock1.21.42.50.8-0.90.91.6-1.01.2-1.6
Seeking ratio, punishment vs. effort0.91.44.8-0.30.20.20.9-2.22.0-0.1
Retroperitoneal fat weight0.52.15.8-1.92.0-2.4-0.5-0.20.7-0.4
Reaction time number correct0.81.55.5-0.20.10.00.9-2.32.0-0.7
Reaction time mean minus median0.10.41.7-0.30.20.1-0.8-0.3-0.11.3
Reaction time mean minus median AUC0.20.52.0-0.50.5-0.2-0.90.0-0.11.4
Reaction time num false alarms2.33.36.42.5-2.51.82.21.40.40.4
Reaction time num false alarms AUC1.82.85.42.3-2.21.71.81.50.00.7
Reaction time trials correct on left0.81.55.5-0.20.10.00.9-2.32.0-0.7
Reaction time trials on left0.91.65.6-0.10.00.01.0-2.42.1-0.7
Reaction time mean0.30.40.70.7-0.60.20.80.80.1-0.8
Reaction time mean AUC0.30.41.20.6-0.5-0.00.71.1-0.0-0.8
Median of all reaction times0.81.11.81.1-1.00.41.31.30.0-1.3
Reaction time omissions1.01.44.41.3-1.30.62.10.31.2-0.4
Reaction time false alarm rate2.12.95.32.2-2.11.61.42.3-0.80.9
Reaction time premature initiation rate0.30.51.70.1-0.10.21.0-0.81.3-0.2
Reaction time premature initiations0.91.75.4-0.30.20.01.2-2.12.3-0.6
Std. dev. reaction times0.00.00.1-0.20.2-0.3-0.10.20.30.1
Reaction time trials completed0.91.65.6-0.10.00.01.0-2.42.1-0.7
Reaction time trials AUC0.81.56.0-0.20.10.10.8-2.42.0-0.5
Run reversals in cocaine runway, females0.80.81.80.9-1.01.40.3-0.6-0.21.2
Run reversals in cocaine runway, males0.30.31.0-0.1-0.00.4-0.2-1.00.2-1.0
Latency to leave start box in cocaine runway1.82.05.01.7-1.82.21.5-0.60.60.2
Latency to leave start box in cocaine runway, F0.50.61.70.6-0.71.30.4-0.90.60.6
Latency to leave start box in cocaine runway, M3.12.95.62.3-2.42.21.90.40.0-0.3
Std. dev. time between licks in bursts0.20.30.9-0.40.5-0.9-0.20.3-0.1-1.0
Total sessions with >9 infusions1.72.14.71.2-1.20.52.2-0.21.9-1.8
Short access day 1 total inactive lever presses0.81.12.21.0-1.00.71.5-0.11.3-1.2
Short access day 10 total inactive lever presses0.10.20.7-0.10.2-0.70.7-0.00.8-0.1
Short access day 1 total infusions0.60.82.10.6-0.5-0.41.30.41.2-1.4
Short access day 10 total infusions1.11.43.60.4-0.40.21.4-1.11.9-1.7
Short access total infusions1.41.84.20.8-0.80.12.0-0.41.8-2.1
Short access day 1 locomotion1.01.33.9-0.20.2-1.11.2-0.11.4-2.0
Short access day 10 total locomotion1.22.26.9-0.30.2-0.51.6-2.02.6-1.4
Short access total locomotion3.13.88.91.2-1.10.03.0-0.52.7-2.7
One hour access (0.3 mA shock)1.41.74.90.2-0.30.41.3-2.12.2-0.6
Compulsive drug intake0.40.40.90.9-0.90.80.60.5-0.20.1
One hour access (shock baseline)0.60.92.10.4-0.40.51.1-1.31.5-0.6
Social response proportion0.50.61.1-0.50.5-0.4-1.10.2-1.01.0
Social responses0.60.81.7-1.21.1-0.8-1.3-0.5-0.30.2
Social time0.30.30.70.7-0.80.80.00.4-0.60.3
Soleus weight0.31.03.3-0.30.3-0.50.8-1.11.8-1.1
Bone: stiffness1.01.62.9-1.61.7-1.6-1.50.2-0.70.2
Tibialis anterior weight1.55.011.3-2.92.9-3.4-1.2-1.11.4-1.5
Time to tail flick, vehicle, before self-admin0.40.40.8-0.90.9-0.6-0.8-0.20.10.4
Time to tail flick, vehicle, after self-admin0.10.10.4-0.20.2-0.5-0.20.3-0.1-0.7
Time to tail flick, test, before self-admin0.10.20.4-0.20.2-0.30.3-0.30.6-0.5
Time to tail flick, test, after self-admin0.60.61.70.7-0.70.6-0.21.3-1.2-0.0
Delta time to tail flick, vehicle, before/after SA0.60.62.30.6-0.5-0.30.90.60.1-1.5
Delta time to tail flick, test, before/after SA1.01.12.11.2-1.11.00.31.4-1.3-0.4
Tibia length0.51.43.9-1.11.0-0.60.3-2.01.50.8
Ambulatory time before self-admin1.42.24.81.3-1.31.12.2-0.71.3-1.9
Ambulatory time after self-admin0.60.83.00.5-0.50.31.1-0.30.6-1.7
Bone: tissue strength1.61.63.0-1.51.5-1.1-1.5-0.6-0.21.7
Total heroin consumption2.12.44.12.0-2.01.62.00.70.6-1.3
Bone: trabecular number0.20.30.9-0.50.5-0.2-1.00.1-0.60.7
Bone: trabecular spacing0.70.92.0-1.11.2-1.4-1.10.6-0.70.1
Bone: trabecular thickness1.62.03.71.6-1.50.61.51.6-0.4-1.9
Bone: trabecular tissue density0.50.83.20.5-0.3-0.40.41.8-1.2-0.0
Water consumed over 24 hours0.60.91.5-0.60.7-0.6-1.21.0-1.20.8
Number of responses in last shaping day2.12.37.71.2-1.0-0.12.01.30.8-2.8