Hub : Genes

Slco2a1

solute carrier organic anion transporter family, member 2a1

chr8:112467739–112551923 (+)

Slco2a1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Slco2a1 0.07 0.05 4.3e-03 0.01 0.01 0.01 0.01 6.1e-02 1.4e-02 1.1e-02 2.2e-02
2 Liver alternative TSS NM_022667.3 0.14 0.08 2.5e-10 0.08 0.07 0.06 0.08 2.5e-09 1.3e-08 1.0e-07 7.9e-09
3 Liver alternative TSS XM_039080798.2 0.16 0.08 1.0e-10 0.08 0.07 0.07 0.07 3.3e-09 2.6e-08 8.0e-08 2.2e-08
4 Liver alternative TSS XM_006243655.4 0.28 0.11 0.0e+00 0.16 0.16 0.16 0.16 1.9e-17 2.2e-17 2.5e-17 1.9e-17
5 NAcc alternative TSS XM_039080798.2 0.03 0.02 9.8e-04 0.03 0.02 0.03 0.03 4.6e-05 6.4e-04 8.0e-05 9.5e-05
6 Liver isoform ratio XM_039080798.2 0.08 0.05 2.2e-04 0.02 0.01 0.02 0.01 8.8e-04 8.4e-03 1.1e-03 7.7e-03
7 Liver intron excision ratio chr8_112516215_112533413 0.09 0.06 3.2e-05 0.03 0.02 0.02 0.02 9.2e-05 3.5e-03 1.8e-03 1.1e-03
8 Liver alternative TSS NM_022667.3 0.25 0.11 0.0e+00 0.15 0.15 0.15 0.15 4.0e-16 4.6e-16 5.7e-16 5.5e-16
9 Liver intron excision ratio chr8_112520573_112533413 0.08 0.05 1.0e-03 0.01 0.01 0.01 0.01 3.6e-02 3.2e-02 2.3e-02 2.3e-02
10 Adipose gene expression Slco2a1 0.1 0.07 6.7e-05 0.03 0.03 0.02 0.03 1.3e-04 1.6e-04 1.7e-03 2.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.10.20.5-0.00.00.0-0.10.4-0.4-0.0-0.1-0.4
Area under the delay curve2.32.73.41.3-1.81.81.81.81.6-1.6-1.61.8-1.0
BMI with tail1.03.34.61.3-2.12.12.12.11.6-1.6-1.91.7-1.4
BMI without tail6.218.923.34.1-4.64.64.64.83.9-3.9-4.74.2-3.8
Body weight3.917.018.14.2-4.14.14.14.14.2-4.2-4.14.0-4.1
Weight adjusted by age0.20.41.51.2-0.50.50.50.40.3-0.3-0.40.4-0.9
Bone surface1.01.82.4-0.91.5-1.5-1.5-1.5-1.21.21.4-1.61.3
Bone volume0.30.50.9-0.30.8-0.8-0.8-0.9-0.50.50.7-0.90.5
Breakpoint value in progressive ratio session0.20.20.6-0.00.3-0.3-0.3-0.5-0.80.80.1-0.20.5
Number of licking bursts0.10.10.20.2-0.50.50.50.40.3-0.3-0.50.4-0.2
Context. condit. distance diff. score3.33.96.72.1-1.71.71.71.82.2-2.2-1.71.6-2.6
Locomotion velocity, session 10.10.10.40.6-0.20.20.20.10.3-0.3-0.2-0.1-0.4
Locomotion distance, session 10.00.00.20.4-0.20.20.20.00.1-0.1-0.2-0.2-0.1
Locomotion velocity, session 20.00.10.10.20.3-0.3-0.3-0.30.1-0.10.2-0.2-0.3
Locomotion distance, session 20.10.10.40.6-0.30.30.30.20.2-0.2-0.2-0.1-0.2
Locomotion velocity, session 30.20.20.40.4-0.60.60.60.6-0.10.1-0.4-0.0-0.3
Locomotion distance, session 30.30.40.8-0.60.4-0.4-0.4-0.5-0.80.80.5-0.90.7
Stereotopy head waving bouts, day 30.00.00.1-0.20.2-0.2-0.2-0.1-0.30.30.1-0.00.2
Stereotopy head waving duration, day 30.00.00.10.1-0.00.00.00.1-0.10.1-0.20.30.1
Locomotion velocity, session 70.10.20.20.4-0.40.40.40.40.5-0.5-0.30.1-0.4
Locomotion distance, session 70.00.10.2-0.10.2-0.2-0.2-0.30.0-0.00.5-0.20.0
Stereotopy head waving bouts, day 70.10.10.4-0.60.3-0.3-0.3-0.3-0.40.40.1-0.60.3
Stereotopy head waving duration, day 70.00.00.1-0.3-0.00.00.0-0.0-0.20.2-0.2-0.30.2
Locomotion velocity, session 82.02.43.11.6-1.61.61.61.61.5-1.5-1.51.1-1.8
Locomotion distance, session 82.43.55.92.2-1.71.71.71.72.0-2.0-1.51.3-2.4
Degree of sensitization distance0.30.30.60.5-0.40.40.40.40.8-0.8-0.30.7-0.7
Degree of sensitization stereotypy0.00.00.2-0.10.0-0.0-0.0-0.10.0-0.0-0.2-0.4-0.0
Conditioned locomotion0.40.40.6-0.50.6-0.6-0.6-0.6-0.80.80.6-0.70.6
Cocaine response after cond. corrected0.20.30.50.3-0.40.40.40.40.7-0.7-0.40.7-0.5
Cocaine response after cond. not corrected0.50.60.90.5-0.70.70.70.61.0-1.0-0.60.9-0.8
Cocaine response before conditioning0.20.30.40.6-0.50.50.50.50.6-0.6-0.40.3-0.7
Saline control response1.21.52.41.1-1.41.41.41.51.1-1.1-1.40.9-1.0
Bone: connectivity density0.00.00.10.3-0.10.10.10.10.2-0.20.0-0.0-0.2
Bone: cortical apparent density0.91.21.5-1.21.2-1.2-1.2-1.2-0.90.90.9-1.01.0
Bone: cortical area0.40.61.01.0-0.80.80.80.60.9-0.9-0.90.6-0.7
Bone: cortical porosity0.40.40.7-0.40.5-0.5-0.5-0.6-0.80.80.4-0.80.8
Bone: cortical porosity0.20.30.5-0.30.4-0.4-0.4-0.5-0.60.60.3-0.70.7
Bone: cortical thickness0.91.51.91.2-1.21.21.21.01.4-1.4-1.31.2-1.3
Bone: cortical thickness0.00.00.10.3-0.10.10.10.00.2-0.2-0.30.2-0.1
Bone: cortical tissue density0.81.11.4-1.21.2-1.2-1.2-1.2-0.90.90.9-1.01.0
Condit. Reinf. active minus inactive responses0.10.10.40.3-0.30.30.30.30.4-0.4-0.30.5-0.6
Condit. Reinf. active-inactive response ratio1.21.31.61.1-1.11.11.11.11.2-1.2-1.11.0-1.3
Condit. Reinf. active responses0.00.00.1-0.10.0-0.0-0.0-0.00.0-0.00.10.2-0.3
Condit. Reinf. inactive responses0.30.40.7-0.70.7-0.7-0.7-0.7-0.60.60.8-0.50.5
Incentive salience index mean0.00.00.1-0.30.0-0.0-0.0-0.0-0.20.20.2-0.00.0
Condit. Reinf. lever presses0.20.30.6-0.80.4-0.4-0.4-0.4-0.70.70.5-0.50.7
Condit. Reinf. active minus inactive responses0.91.22.5-1.21.1-1.1-1.1-1.0-1.01.01.1-0.71.6
Condit. Reinf. active-inactive response ratio0.20.20.70.4-0.40.40.40.50.5-0.5-0.40.8-0.1
Condit. Reinf. active responses1.82.53.4-1.61.5-1.5-1.5-1.6-1.61.61.6-1.31.8
Condit. Reinf. inactive responses4.86.26.8-2.62.4-2.4-2.4-2.6-2.62.62.5-2.62.2
Condit. Reinf. lever presses0.91.21.8-1.41.1-1.1-1.1-1.1-1.01.01.2-0.81.2
Condit. Reinf. lever reinforcers received1.62.23.2-1.61.4-1.4-1.4-1.4-1.61.61.4-1.11.8
Conditioned reinforcement - actives1.52.53.11.8-1.61.61.61.51.6-1.6-1.41.6-1.7
Conditioned reinforcement - inactives0.10.10.4-0.1-0.40.40.40.30.6-0.6-0.20.3-0.2
Conditioned locomotion0.81.01.91.4-1.11.11.11.10.6-0.6-1.01.0-0.7
Patch foraging indifference point 0 sec0.10.20.70.8-0.30.30.30.20.4-0.4-0.30.3-0.3
Patch foraging indifference point AUC0.10.10.4-0.30.2-0.2-0.2-0.30.1-0.10.40.20.6
Delay disc. indifference point, 0s delay0.80.91.30.9-1.11.11.11.10.6-0.6-1.01.1-0.4
Delay disc. indifference point, 16s delay1.51.72.11.1-1.41.41.41.41.2-1.2-1.31.3-1.0
Delay disc. indifference point, 2s delay1.71.92.41.2-1.51.51.51.61.2-1.2-1.31.4-0.9
Delay disc. indifference point, 24s delay0.91.01.50.8-1.01.01.01.01.0-1.0-0.91.2-0.8
Delay disc. indifference point, 4s delay1.01.11.50.7-1.21.21.21.21.1-1.1-0.91.1-0.6
Delay disc. indifference point, 8s delay1.11.31.70.9-1.31.31.31.21.0-1.0-1.21.3-0.5
Indifference point function ln k0.10.20.4-0.50.3-0.3-0.3-0.3-0.60.60.1-0.60.2
Indifference point function log k0.10.20.4-0.50.3-0.3-0.3-0.3-0.60.60.1-0.60.2
Patch foraging total patch changes 0 sec0.00.00.20.50.0-0.0-0.0-0.20.1-0.1-0.00.10.1
Patch foraging total patch changes 12 sec0.10.10.2-0.20.3-0.3-0.3-0.50.1-0.10.5-0.10.5
Patch foraging total patch changes 18 sec0.60.92.21.5-0.60.60.60.61.2-1.2-0.71.1-0.9
Patch foraging total patch changes 24 sec0.00.10.30.2-0.10.10.1-0.00.5-0.5-0.20.4-0.2
Patch foraging total patch changes 6 sec0.10.10.2-0.30.3-0.3-0.3-0.3-0.20.20.5-0.30.5
Patch foraging time to switch 0 sec0.00.00.10.20.0-0.0-0.00.20.1-0.1-0.2-0.1-0.3
Patch foraging water rate 0 sec0.30.61.20.8-0.90.90.90.50.7-0.7-0.71.1-0.4
Patch foraging water rate 12 sec1.73.54.31.5-1.91.91.91.72.1-2.1-1.92.0-1.5
Patch foraging water rate 18 sec1.42.12.61.1-1.61.61.61.41.5-1.5-1.51.4-1.2
Patch foraging water rate 24 sec1.92.63.41.8-1.81.81.81.61.1-1.1-1.71.7-1.4
Patch foraging water rate 6 sec1.82.73.41.5-1.61.61.61.31.8-1.8-1.61.8-1.4
Seeking ratio, delayed vs. immediate footshock0.50.61.2-0.40.7-0.7-0.7-0.5-1.11.10.6-1.10.8
Distance traveled before self-admin2.63.45.01.6-2.22.22.22.21.1-1.1-2.11.7-1.1
Distance traveled after self-admin0.40.51.30.7-0.70.70.70.60.5-0.5-0.60.3-1.2
Extensor digitorum longus weight0.41.42.31.2-1.21.21.21.21.1-1.1-1.21.5-1.0
Bone: elastic displacement1.51.72.41.6-1.21.21.21.21.4-1.4-1.21.4-1.2
Bone: elastic work2.83.64.62.1-1.91.91.91.81.9-1.9-2.11.9-1.6
Bone: endosteal estimation0.00.00.20.00.0-0.0-0.0-0.0-0.20.2-0.0-0.40.4
Bone: endosteal perimeter0.20.40.7-0.50.5-0.5-0.5-0.5-0.60.60.6-0.80.8
Epididymis fat weight0.30.91.70.7-1.21.21.21.30.4-0.4-1.11.0-0.1
Delta time in closed arm before/after self-admin0.50.41.2-0.1-1.01.01.01.10.1-0.1-0.30.20.1
Delta time in open arm before/after self-admin0.10.10.5-0.30.1-0.1-0.1-0.10.2-0.2-0.20.10.7
Diff in mean of infusions in LGA sessions0.30.40.60.4-0.70.70.70.70.4-0.4-0.80.70.1
Delay discount exponential model param2.73.03.8-1.41.9-1.9-1.9-1.9-1.71.71.7-1.91.1
Extinction: sum of active levers before priming0.40.50.70.7-0.80.80.80.70.6-0.6-0.80.6-0.1
Active lever presses in extinction session 61.11.11.90.8-1.31.31.31.40.8-0.8-1.21.1-0.2
Bone: final force0.61.01.41.1-1.01.01.00.81.1-1.1-1.20.9-0.9
Bone: final moment0.71.21.51.2-1.01.01.00.91.2-1.2-1.21.0-1.0
Food consumed during 24 hour testing period0.50.61.11.1-0.70.70.70.80.9-0.9-0.70.6-0.7
Glucose4.36.88.22.5-2.52.52.52.42.9-2.9-2.42.8-2.8
Heart weight2.13.34.81.5-2.22.22.22.11.3-1.3-2.01.7-1.3
Delay discount hyperbolic model param2.12.32.9-1.21.7-1.7-1.7-1.7-1.51.51.5-1.60.9
Intermittent access intake day 1-15 change1.02.03.81.1-1.11.11.11.12.0-2.0-1.01.6-1.6
Intermittent access intake escalation0.71.53.30.7-0.90.90.90.81.8-1.8-0.81.3-1.5
Intermittent access intake escalation 20.20.20.8-0.00.1-0.1-0.1-0.10.9-0.90.10.4-0.8
Intermitt. access day 1 inactive lever presses0.10.50.7-0.80.5-0.5-0.5-0.5-0.80.80.7-0.90.4
Intermitt. access day 15 inactive lever presses0.61.31.9-1.41.1-1.1-1.1-1.1-1.31.31.1-1.30.7
Intermitt. access escalation Index0.10.10.30.1-0.40.40.40.40.2-0.2-0.30.20.5
Intermittent access day 1 total infusions0.40.71.51.2-1.01.01.00.90.3-0.3-0.90.7-0.8
Intermittent access day 15 total infusions1.52.22.61.5-1.41.41.41.31.6-1.6-1.31.6-1.6
Intermittent access terminal intake (last 3 days)3.24.26.02.4-1.81.81.81.82.2-2.2-1.82.1-2.5
Intermittent access total infusions2.32.73.71.9-1.61.61.61.51.6-1.6-1.51.7-1.8
Intermittent access day 1 locomotion0.20.20.70.8-0.60.60.60.5-0.00.0-0.40.4-0.3
Intermittent access day 15 total locomotion2.13.94.82.2-2.12.12.12.01.6-1.6-2.01.9-1.9
Intermittent access total locomotion2.02.43.82.0-1.61.61.61.51.2-1.2-1.41.5-1.6
Intermittent access standard deviation0.40.91.7-0.61.2-1.2-1.2-1.3-0.40.41.3-0.7-0.3
Left kidney weight0.21.12.40.9-0.90.90.91.01.6-1.6-1.00.6-0.7
Right kidney weight0.42.03.21.7-1.31.31.31.21.8-1.8-1.21.0-1.2
Cocaine induced anxiety0.71.01.4-1.21.1-1.1-1.1-1.1-0.50.51.1-1.00.7
Post-drug Anxiety0.10.10.3-0.30.4-0.4-0.4-0.40.1-0.10.5-0.3-0.3
Baseline Anxiety0.50.61.10.8-0.80.80.80.80.6-0.6-0.70.8-1.0
Tail length3.915.220.94.6-3.73.73.73.93.8-3.8-3.93.9-4.0
Length with tail2.19.213.33.6-2.72.72.72.73.2-3.2-2.83.0-3.4
Length without tail0.72.24.01.7-1.11.11.10.91.9-1.9-1.21.5-2.0
LgA early post infusion interval2.02.73.3-1.61.7-1.7-1.7-1.8-1.61.61.6-1.61.6
LgA late post infusion interval1.11.32.2-0.71.0-1.0-1.0-1.0-1.41.41.0-1.51.3
LgA early loading3.97.28.12.4-2.82.82.82.92.7-2.7-2.82.6-2.4
LgA late loading2.66.18.72.4-2.12.12.12.22.9-2.9-2.32.4-3.0
LgA early average infusions1.11.42.10.8-1.31.31.31.51.1-1.1-1.21.1-0.8
LgA late average infusions1.42.03.81.4-1.01.01.01.11.8-1.8-1.11.6-1.9
LgA early timeout1.51.62.21.1-1.41.41.41.51.4-1.4-1.21.0-0.9
LgA late timeout0.30.40.80.2-0.60.60.60.70.7-0.7-0.40.5-0.9
LgA early titration0.60.81.50.5-1.01.01.01.20.8-0.8-1.00.9-0.3
LgA late titration0.10.20.60.1-0.10.10.10.30.8-0.8-0.20.7-0.6
LgA total infusion0.91.31.80.8-1.01.01.01.21.3-1.3-1.11.2-1.2
Times rat made contact with spout0.10.10.20.40.3-0.3-0.3-0.30.1-0.10.4-0.5-0.0
Lifetime Intake1.21.52.81.7-1.11.11.11.11.1-1.1-1.01.3-1.5
Liver weight, left0.10.20.50.7-0.40.40.40.40.3-0.3-0.40.4-0.4
Liver weight, right0.50.81.21.1-0.80.80.80.71.0-1.0-0.80.8-0.9
Locomotor activity1.11.72.50.9-1.31.31.31.21.6-1.6-1.21.0-1.4
Locomotor testing distance0.30.61.00.3-0.70.70.70.71.0-1.0-0.80.3-1.0
Locomotor testing rearing0.10.31.0-1.00.6-0.6-0.6-0.5-0.20.20.4-0.50.5
Locomotion in novel chamber3.14.05.9-1.92.4-2.4-2.4-2.3-1.31.32.2-1.91.1
Locomotion in novel chamber post-restriction0.30.50.80.3-0.60.60.60.90.8-0.8-0.60.8-0.9
Fecal boli incidents, locomotor time 10.10.10.40.2-0.10.10.10.00.3-0.3-0.20.4-0.6
Change in fecal boli incidents, locomotor task0.00.00.20.00.1-0.1-0.1-0.1-0.10.10.1-0.4-0.1
Time >=10cm from walls, locomotor time 11.81.92.4-1.41.5-1.5-1.5-1.4-1.11.11.4-1.41.3
Bouts of movement, locomotor time 10.10.20.5-0.70.3-0.3-0.3-0.3-0.40.40.2-0.50.3
Total resting periods, locomotor time 10.20.30.5-0.70.4-0.4-0.4-0.4-0.60.60.2-0.50.5
Rest time, locomotor task time 10.50.60.8-0.50.9-0.9-0.9-0.9-0.80.80.8-0.70.6
Distance moved, locomotor task time 11.31.92.71.1-1.61.61.61.61.0-1.0-1.61.2-0.8
Vertical activity count, locomotor time 10.00.10.20.0-0.20.20.20.2-0.10.1-0.40.20.3
Time >=10cm from walls, locomotor time 20.10.10.3-0.40.4-0.4-0.4-0.3-0.30.30.4-0.20.6
Bouts of movement, locomotor time 20.10.20.3-0.40.5-0.5-0.5-0.3-0.40.40.6-0.40.3
Total resting periods, locomotor time 20.10.20.3-0.40.4-0.4-0.4-0.3-0.50.50.6-0.40.4
Rest time, locomotor task time 20.60.71.1-0.41.1-1.1-1.1-1.0-0.70.70.9-0.80.5
Distance moved, locomotor task time 21.11.32.30.7-1.51.51.51.40.6-0.6-1.30.8-0.4
Vertical activity count, locomotor time 20.81.12.8-1.30.4-0.4-0.4-0.6-1.41.40.6-1.11.7
Light reinforcement 11.74.14.72.0-2.12.12.12.21.7-1.7-2.02.0-2.1
Light reinforcement 23.04.65.42.3-2.32.32.32.21.8-1.8-2.01.9-2.3
Bone: marrow area0.00.00.20.0-0.00.00.0-0.0-0.20.2-0.1-0.40.4
Bone: maximum diameter0.00.00.10.4-0.10.10.1-0.00.2-0.2-0.3-0.10.1
Bone: maximum force0.50.81.41.2-0.80.80.80.71.0-1.0-1.10.8-0.9
Bone: maximum moment0.61.01.51.2-0.90.90.90.81.1-1.1-1.10.8-1.0
Mean time between licks in bursts0.10.10.3-0.50.3-0.3-0.3-0.3-0.50.50.3-0.20.4
Mean num. licks in bursts0.10.20.30.20.5-0.5-0.5-0.5-0.10.10.6-0.50.0
Cd content in liver1.41.61.81.2-1.21.21.21.31.3-1.3-1.31.2-1.3
Co content in liver0.20.20.3-0.30.4-0.4-0.4-0.5-0.50.50.4-0.30.4
Cu content in liver0.10.10.5-0.2-0.10.10.10.1-0.30.3-0.3-0.20.7
Fe content in liver0.81.01.71.2-1.11.11.11.10.7-0.7-1.31.0-0.5
K content in liver0.10.10.3-0.4-0.20.20.20.1-0.10.1-0.10.50.5
Mg content in liver0.10.10.4-0.50.2-0.2-0.2-0.2-0.30.30.20.10.6
Mn content in liver0.10.20.7-0.70.1-0.1-0.1-0.2-0.40.40.1-0.10.8
Na content in liver0.10.10.10.2-0.40.40.40.30.0-0.0-0.20.30.1
Rb content in liver2.22.53.91.4-1.61.61.61.61.5-1.5-1.72.0-1.3
Se content in liver0.00.00.1-0.2-0.20.20.20.2-0.20.2-0.20.10.1
Sr content in liver0.70.60.70.6-0.80.80.80.80.8-0.8-0.80.8-0.8
Zn content in liver0.20.30.5-0.0-0.60.60.60.60.4-0.4-0.60.7-0.2
Bone: minimum diameter0.00.00.00.1-0.10.10.1-0.00.0-0.0-0.1-0.20.1
Time in familiar zone, hab. session 13.83.74.1-1.62.0-2.0-2.0-2.0-1.91.91.9-2.01.8
Time in novel zone, hab. session 17.17.17.72.1-2.82.82.82.72.7-2.7-2.82.7-2.5
Total zone transitions, hab. session 10.81.01.41.0-1.21.21.21.10.9-0.9-1.00.8-0.9
Total locomotion distance, hab. session 10.20.20.4-0.20.5-0.5-0.5-0.5-0.60.60.4-0.60.3
Locomotion velocity, hab. session 10.10.20.4-0.10.4-0.4-0.4-0.4-0.60.60.4-0.60.3
Time in familiar zone, hab. session 21.41.42.2-0.91.5-1.5-1.5-1.3-1.11.11.1-0.90.9
Time in novel zone, hab. session 22.52.53.81.2-1.91.91.91.81.4-1.4-1.61.2-1.2
Total zone transitions, hab. session 20.00.00.1-0.10.2-0.2-0.2-0.2-0.30.30.1-0.4-0.1
Total locomotion distance, hab. session 21.82.43.0-1.21.7-1.7-1.7-1.7-1.51.51.5-1.61.1
Locomotion velocity, hab. session 22.53.44.0-1.52.0-2.0-2.0-1.9-1.91.91.8-2.01.5
Novel to familiar place preference ratio0.20.20.50.2-0.70.70.70.70.3-0.3-0.3-0.1-0.2
Novelty place preference0.40.40.80.3-0.90.90.90.90.5-0.5-0.50.0-0.4
Time in novel zone, NPP test0.40.50.90.4-0.90.90.91.00.6-0.6-0.50.2-0.5
Total zone transitions, NPP test0.00.00.10.3-0.00.00.0-0.00.1-0.1-0.1-0.1-0.4
Total locomotion distance, NPP test0.20.30.4-0.20.6-0.6-0.6-0.6-0.60.60.5-0.50.3
Locomotion velocity, NPP test0.30.40.6-0.20.6-0.6-0.6-0.6-0.80.80.6-0.70.5
Intraocular pressure0.00.00.0-0.00.1-0.1-0.1-0.10.1-0.10.1-0.2-0.0
Delta distance traveled before/after self-admin0.20.20.3-0.10.5-0.5-0.5-0.40.1-0.10.4-0.5-0.2
Delta ambulatory time before/after self-admin0.10.20.30.00.5-0.5-0.5-0.50.2-0.20.4-0.5-0.4
Parametrial fat weight3.99.19.53.0-3.03.03.03.12.9-2.9-3.13.0-3.0
Pavlov. Cond. lever latency1.31.61.91.3-1.31.31.31.21.2-1.2-1.21.3-1.4
Pavlov. Cond. magazine entry latency3.24.14.6-1.82.1-2.1-2.1-1.9-2.02.02.0-2.22.1
Pavlov. Cond. change in total contacts3.84.15.0-2.02.2-2.2-2.2-2.2-1.71.72.1-2.01.8
Pavlov. Cond. index score3.34.24.6-1.92.1-2.1-2.1-1.9-2.02.02.0-2.12.0
Pavlov. Cond. latency score2.32.93.4-1.61.7-1.7-1.7-1.6-1.71.71.7-1.81.8
Pavlov. Cond. lever contacts1.82.12.5-1.41.5-1.5-1.5-1.4-1.41.41.4-1.61.5
Pavlov. Cond. magazine entry number4.25.25.72.1-2.42.42.42.22.3-2.3-2.22.4-2.3
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.20.2-0.2-0.2-0.2-0.30.30.5-0.3-0.1
Pavlov. Cond. lever-magazine prob. diff.4.45.46.0-2.32.4-2.4-2.4-2.3-2.22.22.3-2.42.2
Pavlov. Cond. response bias3.03.74.1-1.82.0-2.0-2.0-1.8-1.91.91.9-2.01.9
Pavlov. Cond. lever latency1.82.53.61.9-1.51.51.51.61.6-1.6-1.61.2-1.7
Pavlov. Cond. magazine entry latency2.83.43.8-1.71.9-1.9-1.9-1.9-1.81.82.0-1.71.7
Pavlov. Cond. change in total contacts1.21.92.4-1.51.4-1.4-1.4-1.4-1.51.51.4-1.11.3
Pavlov. Cond. index score2.53.43.9-2.01.9-1.9-1.9-1.8-1.91.91.9-1.51.8
Pavlov. Cond. latency score2.93.84.1-2.02.0-2.0-2.0-1.9-2.02.02.0-1.72.0
Pavlov. Cond. lever contacts1.52.13.1-1.81.4-1.4-1.4-1.5-1.41.41.5-1.11.5
Pavlov. Cond. magazine entry number5.26.46.82.5-2.62.62.62.52.6-2.6-2.62.3-2.5
Pavlov. Cond. intertrial magazine entries0.30.40.8-0.90.6-0.6-0.6-0.7-0.60.60.7-0.60.6
Pavlov. Cond. lever-magazine prob. diff.2.53.33.9-2.01.8-1.8-1.8-1.8-1.81.81.9-1.51.8
Pavlov. Cond. response bias2.73.64.6-2.21.9-1.9-1.9-1.9-1.91.92.0-1.51.9
LgA PC1 addiction-like behavior1.52.93.51.3-1.71.71.71.91.8-1.8-1.71.7-1.8
Time in closed arm before self-admin0.40.50.9-0.50.9-0.9-0.9-0.9-0.40.40.7-0.60.2
Time in closed arm after self-admin0.40.40.8-0.90.5-0.5-0.5-0.4-0.60.60.8-0.60.7
Time in open arm before self-admin0.10.10.30.1-0.30.30.30.20.3-0.3-0.20.1-0.5
Time in open arm after self-admin0.10.20.8-0.8-0.00.00.0-0.10.1-0.1-0.1-0.20.9
Bone: periosteal estimation0.10.30.50.7-0.60.60.60.50.5-0.5-0.70.2-0.3
Bone: periosteal perimeter0.10.10.3-0.20.3-0.3-0.3-0.4-0.40.40.2-0.60.6
Bone: post-yield work0.00.00.10.10.0-0.0-0.0-0.10.2-0.2-0.10.2-0.3
Progressive ratio test 1 active lever presses2.73.44.22.1-1.71.71.71.71.9-1.9-1.62.0-2.0
Progressive ratio test 1 breakpoint2.83.54.22.0-1.81.81.81.71.9-1.9-1.72.1-1.9
Progressive ratio test 1 inactive lever presses0.00.00.10.1-0.30.30.30.20.0-0.00.00.1-0.3
Progressive ratio test 2 active lever presses1.51.73.01.6-1.11.11.11.11.4-1.4-1.01.3-1.7
Progressive ratio test 2 breakpoint1.61.83.21.6-1.21.21.21.11.5-1.5-1.01.3-1.8
Progressive ratio test 2 inactive lever presses0.10.20.80.8-0.30.30.30.20.4-0.4-0.00.3-0.9
ShA PR total presses0.60.71.20.5-1.01.01.01.10.7-0.7-0.80.8-0.7
Incentive Sensitization - Responses0.71.02.81.5-0.60.60.60.61.1-1.1-0.60.8-1.7
Incentive Sensitization - Breakpoint0.70.92.61.4-0.60.60.60.51.0-1.0-0.50.7-1.6
LgA PR total presses0.20.20.4-0.50.5-0.5-0.5-0.3-0.20.20.6-0.60.2
Sum of active levers in priming session hrs 5-60.80.81.71.3-0.90.90.90.90.6-0.6-1.10.8-0.6
Progressive ratio1.11.72.6-0.81.4-1.4-1.4-1.3-1.61.61.5-1.20.9
Food seeking constrained by brief footshock1.01.22.31.5-1.11.11.11.00.9-0.9-1.10.9-1.3
Seeking ratio, punishment vs. effort2.63.74.41.8-1.91.91.91.82.1-2.1-2.11.8-1.8
Retroperitoneal fat weight2.08.59.73.1-2.92.92.93.02.9-2.9-2.82.8-3.1
Reaction time number correct0.20.40.80.7-0.60.60.60.20.7-0.7-0.70.9-0.5
Reaction time mean minus median0.00.10.6-0.8-0.20.20.20.20.1-0.1-0.30.20.5
Reaction time mean minus median AUC0.20.40.7-0.3-0.60.60.60.70.7-0.7-0.80.8-0.1
Reaction time num false alarms0.30.40.7-0.80.5-0.5-0.5-0.6-0.80.80.5-0.50.7
Reaction time num false alarms AUC0.10.20.3-0.50.4-0.4-0.4-0.4-0.50.50.4-0.40.4
Reaction time trials correct on left0.20.40.80.7-0.60.60.60.20.7-0.7-0.70.9-0.5
Reaction time trials on left0.20.40.80.7-0.60.60.60.20.7-0.7-0.70.9-0.5
Reaction time mean0.40.72.2-1.50.5-0.5-0.5-0.3-0.90.90.5-0.81.3
Reaction time mean AUC0.50.82.2-1.50.4-0.4-0.4-0.3-1.01.00.4-0.81.4
Median of all reaction times0.91.22.7-1.60.8-0.8-0.8-0.6-1.31.30.8-1.21.5
Reaction time omissions0.10.10.9-0.90.1-0.1-0.10.0-0.40.40.10.00.4
Reaction time false alarm rate0.20.30.5-0.70.5-0.5-0.5-0.4-0.60.60.5-0.50.5
Reaction time premature initiation rate3.14.37.91.8-1.91.91.91.82.3-2.3-1.82.1-2.8
Reaction time premature initiations2.34.16.91.9-1.81.81.81.52.3-2.3-1.82.1-2.6
Std. dev. reaction times0.20.31.6-1.30.2-0.2-0.2-0.1-0.50.50.1-0.21.1
Reaction time trials completed0.20.40.80.7-0.60.60.60.20.7-0.7-0.70.9-0.5
Reaction time trials AUC0.30.50.90.8-0.70.70.70.30.8-0.8-0.81.0-0.6
Run reversals in cocaine runway, females2.52.53.2-1.51.8-1.8-1.8-1.8-1.31.31.5-1.51.4
Run reversals in cocaine runway, males1.21.21.91.3-0.90.90.91.01.4-1.4-0.90.6-1.2
Latency to leave start box in cocaine runway7.68.611.6-3.42.6-2.6-2.6-2.6-3.43.42.7-2.93.2
Latency to leave start box in cocaine runway, F3.84.36.8-2.51.6-1.6-1.6-1.7-2.62.61.7-1.82.6
Latency to leave start box in cocaine runway, M4.74.45.1-2.22.1-2.1-2.1-2.1-2.12.12.2-2.31.6
Std. dev. time between licks in bursts2.43.34.0-2.01.8-1.8-1.8-1.9-1.91.91.8-1.41.8
Total sessions with >9 infusions0.20.20.70.8-0.50.50.50.40.3-0.3-0.40.6-0.6
Short access day 1 total inactive lever presses0.50.60.9-0.40.7-0.7-0.7-0.8-0.90.90.8-0.90.8
Short access day 10 total inactive lever presses0.71.82.4-1.31.2-1.2-1.2-1.2-1.51.51.4-1.51.3
Short access day 1 total infusions0.10.20.20.30.4-0.4-0.4-0.4-0.50.50.4-0.40.4
Short access day 10 total infusions3.44.36.92.6-2.12.12.12.11.8-1.8-2.02.1-2.1
Short access total infusions0.30.41.41.2-0.60.60.60.50.5-0.5-0.50.7-0.6
ShA early post infusion interval4.34.15.1-2.31.9-1.9-1.9-1.9-2.32.31.8-1.92.1
ShA late post infusion interval1.01.01.6-0.81.1-1.1-1.1-1.3-0.80.80.8-1.11.1
ShA early loading2.92.94.21.4-1.91.91.92.11.7-1.7-1.71.6-1.1
ShA late loading5.87.89.92.0-3.13.13.13.12.7-2.7-2.92.8-2.2
Short access day 1 locomotion0.50.61.21.1-0.90.90.90.90.4-0.4-0.80.8-0.3
Short access day 10 total locomotion0.10.10.70.8-0.20.20.20.2-0.20.2-0.00.3-0.6
Short access total locomotion0.50.61.31.1-0.80.80.80.80.3-0.3-0.70.9-0.8
ShA early average infusions3.64.26.11.7-2.32.32.32.51.9-1.9-2.11.8-1.3
ShA late average infusions1.81.92.90.8-1.51.51.51.71.3-1.3-1.51.4-0.7
ShA early timeout2.52.64.61.4-1.91.91.92.11.3-1.3-1.61.4-0.8
ShA late timeout0.10.10.2-0.2-0.30.30.30.50.3-0.3-0.20.30.2
ShA early titration3.23.64.31.7-1.91.91.92.12.0-2.0-1.91.8-1.5
ShA late titration2.72.83.81.4-1.71.71.72.01.6-1.6-1.71.8-1.3
ShA total infusions1.31.62.50.6-1.41.41.41.61.2-1.2-1.31.3-0.8
One hour access (0.3 mA shock)1.31.42.71.4-1.01.01.00.91.3-1.3-0.91.3-1.6
Shock compulsivity0.10.10.20.2-0.40.40.40.30.4-0.4-0.40.4-0.5
Compulsive drug intake2.83.34.0-1.51.9-1.9-1.9-1.8-1.91.92.0-1.81.4
One hour access (shock baseline)4.77.28.52.9-2.72.72.72.52.6-2.6-2.62.9-2.7
Social response proportion0.30.40.7-0.70.6-0.6-0.6-0.8-0.20.20.7-0.40.6
Social responses0.10.10.30.3-0.30.30.30.20.4-0.4-0.30.6-0.4
Social time3.34.56.6-2.62.1-2.1-2.1-2.0-2.12.12.2-1.92.2
Soleus weight8.424.827.35.2-4.94.94.94.95.1-5.1-5.05.0-4.8
Bone: stiffness0.30.40.9-0.40.8-0.8-0.8-0.9-0.40.40.6-0.70.4
Tibialis anterior weight0.00.10.20.3-0.40.40.40.40.2-0.2-0.40.4-0.1
Time to tail flick, vehicle, before self-admin0.10.10.40.6-0.10.10.1-0.10.4-0.4-0.10.4-0.5
Time to tail flick, vehicle, after self-admin1.41.92.2-1.21.3-1.3-1.3-1.5-1.51.51.4-1.41.3
Time to tail flick, test, before self-admin0.20.20.30.5-0.50.50.50.50.5-0.5-0.60.4-0.3
Time to tail flick, test, after self-admin0.30.41.00.4-0.70.70.71.00.1-0.1-0.70.4-0.3
Delta time to tail flick, vehicle, before/after SA1.21.22.6-1.20.7-0.7-0.7-0.7-1.41.40.8-1.21.6
Delta time to tail flick, test, before/after SA0.20.20.7-0.1-0.60.60.60.8-0.10.1-0.40.20.3
Tibia length0.00.10.30.6-0.00.00.00.00.3-0.3-0.0-0.2-0.2
Ambulatory time before self-admin2.43.55.51.4-2.32.32.32.31.1-1.1-2.11.8-1.1
Ambulatory time after self-admin1.41.72.31.2-1.51.51.51.50.9-0.9-1.31.0-1.4
Bone: tissue strength6.76.77.62.6-2.52.52.52.42.7-2.7-2.62.7-2.8
Total heroin consumption0.91.11.61.2-1.21.21.21.20.5-0.5-1.10.7-1.0
Total infusions0.81.11.40.6-1.01.01.01.21.2-1.2-1.01.1-1.0
Bone: trabecular number0.10.20.3-0.20.5-0.5-0.5-0.6-0.20.20.5-0.50.1
Bone: trabecular spacing0.00.00.1-0.1-0.20.20.20.3-0.00.0-0.10.4-0.2
Bone: trabecular thickness1.01.32.01.4-1.01.01.00.81.3-1.3-1.20.9-1.2
Bone: trabecular tissue density0.10.10.20.4-0.30.30.30.40.5-0.5-0.50.1-0.5
Water consumed over 24 hours0.50.61.3-0.30.9-0.9-0.9-0.9-0.60.60.9-1.10.6
Number of responses in last shaping day0.20.30.4-0.40.5-0.5-0.5-0.5-0.50.50.6-0.50.5