Slco2a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XM_039080798.1	0.1	0.06	3.0e-08	0.04	0.06	0.04	0.05	1.9e-05	9.3e-07	4.2e-05	2.1e-06
2	Liver	isoform ratio	NM_022667.3	0.04	0.03	2.2e-04	0.01	0.02	0.01	0.01	7.2e-02	2.8e-03	1.8e-02	1.5e-02
3	Liver	isoform ratio	XM_039080798.1	0.04	0.03	3.0e-04	0.02	0.02	0.01	0.02	4.8e-03	2.2e-03	2.0e-02	3.5e-03
4	Liver	alternative TSS	XM_039080799.1	0.02	0.01	8.1e-03	0.02	0	0	0	4.0e-03	1.4e-01	1.3e-01	9.6e-02
5	Adipose	gene expression	Slco2a1	0.11	0.08	1.9e-05	0.04	0.04	0.01	0.04	3.7e-05	7.7e-05	3.0e-02	2.7e-05
6	Liver	alternative TSS	NM_022667.3	0.2	0.1	5.6e-13	0.11	0.1	0.1	0.11	7.4e-12	1.0e-11	1.1e-11	6.7e-12
7	Liver	alternative TSS	XM_006243655.3	0.2	0.1	7.6e-14	0.11	0.11	0.11	0.11	1.7e-12	2.3e-12	3.0e-12	1.3e-12
8	Liver	alternative TSS	NM_022667.3	0.15	0.08	8.8e-11	0.09	0.08	0.08	0.08	5.7e-10	2.9e-09	3.4e-09	1.4e-09
9	Liver	intron excision ratio	chr8_103637317_103654517	0.09	0.06	4.6e-05	0.03	0.01	0.01	0.02	5.2e-04	9.2e-03	1.0e-02	5.6e-03
10	Liver	intron excision ratio	chr8_103641675_103654517	0.07	0.05	1.8e-03	0.01	0.01	0	0.01	4.9e-02	5.7e-02	2.0e-01	6.2e-02
11	Liver	mRNA stability	Slco2a1	0.02	0.02	7.3e-03	-0	-0	-0	-0	7.8e-01	3.8e-01	7.6e-01	8.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.4	0.7	2.5	0.6	-0.9	1.0	-1.5	-0.3	-0.3	0.3	0.3	0.3	-0.3	1.6
Area under the delay curve	1.3	1.4	2.3	1.2	-0.8	0.6	0.6	-1.0	-1.3	1.3	1.5	1.5	-1.5	-1.0
BMI with tail	0.8	2.4	3.5	1.8	-1.7	1.5	-0.3	-1.4	-1.7	1.7	1.9	1.9	-1.9	0.1
BMI without tail	3.4	7.1	9.3	3.0	-2.8	2.7	-1.5	-2.6	-2.9	2.9	3.0	3.0	-3.0	0.6
Body weight	3.1	12.9	16.3	4.0	-3.7	3.6	-2.4	-3.6	-3.9	3.9	4.0	4.0	-4.0	1.1
Weight adjusted by age	0.6	0.7	2.9	0.7	-0.7	0.7	-1.7	-1.2	-0.7	0.7	0.3	0.3	-0.3	0.5
Bone surface	0.5	0.9	2.1	-0.6	0.1	0.1	-1.0	1.1	1.1	-1.0	-1.0	-1.0	1.0	1.4
Bone volume	0.3	0.5	2.2	-0.1	-0.3	0.5	-1.3	0.4	0.4	-0.4	-0.4	-0.4	0.4	1.5
Breakpoint value in progressive ratio session	0.6	0.6	1.1	-0.8	1.0	-1.0	0.6	0.6	0.6	-0.7	-0.7	-0.7	0.7	-1.1
Number of licking bursts	0.1	0.1	0.3	0.5	-0.5	0.5	0.4	-0.2	-0.3	0.3	0.4	0.4	-0.4	0.3
Context. condit. distance diff. score	4.7	5.7	9.0	2.5	-2.5	2.6	-3.0	-2.5	-2.3	2.3	2.1	2.1	-2.1	1.9
Locomotion velocity, session 1	0.3	0.3	1.4	0.4	-0.5	0.6	-1.2	-0.2	-0.2	0.2	0.2	0.2	-0.2	1.1
Locomotion distance, session 1	0.6	0.8	3.1	0.6	-0.9	1.1	-1.8	-0.1	-0.1	0.1	0.1	0.1	-0.1	1.7
Locomotion velocity, session 2	0.1	0.1	0.1	-0.0	0.2	-0.2	-0.2	-0.4	-0.3	0.3	0.3	0.3	-0.3	-0.2
Locomotion distance, session 2	0.1	0.1	0.5	0.2	-0.2	0.2	-0.7	-0.0	-0.2	0.2	0.3	0.3	-0.3	-0.0
Locomotion velocity, session 3	0.1	0.2	0.6	0.4	-0.6	0.6	-0.6	-0.1	-0.1	0.0	-0.0	-0.0	0.0	0.8
Locomotion distance, session 3	0.3	0.4	0.8	-0.4	0.0	0.0	-0.3	0.9	0.8	-0.8	-0.7	-0.7	0.7	0.6
Stereotopy head waving bouts, day 3	0.2	0.3	0.8	-0.5	0.6	-0.7	0.6	0.2	0.3	-0.3	-0.3	-0.3	0.3	-0.9
Stereotopy head waving duration, day 3	0.0	0.1	0.4	-0.1	0.2	-0.3	0.2	-0.1	-0.1	0.0	0.0	0.0	-0.0	-0.6
Locomotion velocity, session 7	0.4	0.4	1.2	0.6	-0.8	0.8	-1.0	-0.5	-0.4	0.4	0.4	0.4	-0.4	1.1
Locomotion distance, session 7	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	0.0	0.0	-0.0	-0.0	-0.0	0.0	-0.3
Stereotopy head waving bouts, day 7	0.2	0.3	1.3	-0.1	-0.3	0.4	-0.6	0.5	0.4	-0.4	-0.4	-0.4	0.4	1.1
Stereotopy head waving duration, day 7	0.2	0.2	1.2	0.2	-0.5	0.6	-0.6	0.1	0.1	-0.1	-0.1	-0.1	0.1	1.1
Locomotion velocity, session 8	2.7	3.2	4.8	1.9	-2.1	2.2	-2.2	-1.8	-1.6	1.6	1.4	1.4	-1.4	1.9
Locomotion distance, session 8	4.0	5.8	10.9	2.6	-2.7	2.8	-3.3	-2.2	-2.1	2.1	2.0	2.0	-2.0	2.2
Degree of sensitization distance	0.4	0.4	0.9	0.4	-0.1	-0.0	0.5	-0.9	-0.8	0.8	0.7	0.7	-0.7	-0.7
Degree of sensitization stereotypy	0.6	0.7	3.3	0.5	-1.0	1.1	-1.2	0.0	-0.0	0.1	0.1	0.1	-0.1	1.8
Conditioned locomotion	0.1	0.2	0.4	-0.3	0.1	-0.1	0.1	0.4	0.4	-0.4	-0.5	-0.5	0.5	0.6
Cocaine response after cond. corrected	0.4	0.5	1.8	0.2	0.2	-0.4	1.3	-0.4	-0.5	0.5	0.6	0.6	-0.6	-1.3
Cocaine response after cond. not corrected	0.5	0.6	1.1	0.5	-0.1	-0.0	1.0	-0.6	-0.7	0.8	0.9	0.9	-0.9	-1.0
Cocaine response before conditioning	0.3	0.4	0.8	0.7	-0.8	0.8	-0.9	-0.6	-0.5	0.5	0.4	0.4	-0.4	0.8
Saline control response	1.5	1.9	2.8	1.5	-1.6	1.7	-1.4	-1.2	-1.2	1.3	1.3	1.3	-1.3	1.4
Bone: connectivity density	0.1	0.2	0.4	0.4	-0.5	0.5	-0.7	-0.2	-0.2	0.2	0.2	0.2	-0.2	0.6
Bone: cortical apparent density	0.8	1.0	1.6	-1.0	0.7	-0.6	0.1	1.3	1.2	-1.2	-1.2	-1.2	1.2	0.6
Bone: cortical area	1.3	2.0	5.2	1.3	-1.7	1.9	-2.1	-0.7	-0.8	0.8	0.9	0.9	-0.9	2.3
Bone: cortical porosity	0.6	0.7	3.0	-0.3	-0.3	0.4	-1.1	0.6	0.7	-0.7	-0.7	-0.7	0.7	1.7
Bone: cortical porosity	0.7	0.7	3.2	-0.3	-0.3	0.5	-1.2	0.7	0.7	-0.7	-0.8	-0.8	0.8	1.8
Bone: cortical thickness	0.9	1.6	2.3	1.3	-1.5	1.5	-1.4	-0.9	-1.0	1.1	1.1	1.1	-1.1	1.4
Bone: cortical thickness	0.2	0.2	0.7	0.4	-0.5	0.6	-0.6	-0.1	-0.2	0.2	0.3	0.3	-0.3	0.8
Bone: cortical tissue density	0.8	1.1	1.7	-1.1	0.8	-0.7	0.1	1.3	1.3	-1.2	-1.2	-1.2	1.2	0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.4	-0.2	0.2	0.0	-0.7	-0.6	0.6	0.6	0.6	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	1.8	2.0	2.6	1.5	-1.6	1.6	-1.5	-1.4	-1.3	1.3	1.3	1.3	-1.3	1.3
Condit. Reinf. active responses	0.4	0.4	2.3	-0.2	0.6	-0.7	1.2	-0.2	-0.2	0.2	0.2	0.2	-0.2	-1.5
Condit. Reinf. inactive responses	1.0	1.2	3.3	-1.0	1.3	-1.4	1.8	0.7	0.6	-0.6	-0.5	-0.5	0.5	-1.8
Incentive salience index mean	0.2	0.2	1.3	-0.3	0.5	-0.6	0.9	0.0	0.1	-0.1	-0.1	-0.1	0.1	-1.1
Condit. Reinf. lever presses	0.6	0.9	2.9	-0.8	1.0	-1.1	1.3	0.6	0.6	-0.6	-0.6	-0.6	0.6	-1.7
Condit. Reinf. active minus inactive responses	2.1	2.6	5.7	-1.6	2.0	-2.1	1.8	1.5	1.3	-1.2	-1.0	-1.0	1.0	-2.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	3.7	0.0	0.5	-0.7	0.8	-0.2	-0.4	0.4	0.6	0.6	-0.6	-1.9
Condit. Reinf. active responses	2.9	4.1	7.2	-2.1	2.5	-2.6	2.2	1.8	1.7	-1.6	-1.5	-1.5	1.5	-2.7
Condit. Reinf. inactive responses	4.6	5.7	6.9	-2.6	2.5	-2.4	2.0	2.4	2.5	-2.5	-2.6	-2.6	2.6	-1.2
Condit. Reinf. lever presses	2.0	2.6	4.4	-1.7	2.0	-2.1	2.1	1.3	1.3	-1.3	-1.2	-1.2	1.2	-2.1
Condit. Reinf. lever reinforcers received	3.2	4.5	8.3	-2.2	2.6	-2.7	2.4	1.8	1.7	-1.7	-1.6	-1.6	1.6	-2.9
Conditioned reinforcement - actives	3.0	3.0	4.2	1.8	-1.8	1.7	-1.9	-2.0	-1.8	1.8	1.7	1.7	-1.7	1.0
Conditioned reinforcement - inactives	1.4	1.5	2.0	1.4	-1.3	1.3	-0.6	-1.1	-1.3	1.3	1.4	1.4	-1.4	0.8
Conditioned locomotion	0.4	0.5	1.5	0.7	-0.8	0.9	-1.2	-0.8	-0.5	0.5	0.3	0.3	-0.3	1.0
Patch foraging indifference point 0 sec	0.3	0.5	2.7	0.5	-0.7	0.7	-1.6	-0.3	-0.3	0.3	0.3	0.3	-0.3	1.1
Patch foraging indifference point AUC	0.6	0.7	2.5	-0.7	1.0	-1.1	1.6	0.6	0.4	-0.3	-0.1	-0.1	0.1	-1.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.6	-0.4	0.4	-0.1	-0.4	-0.5	0.5	0.6	0.6	-0.6	-0.4
Delay disc. indifference point, 16s delay	1.2	1.2	1.7	1.3	-1.0	0.9	-0.0	-1.2	-1.3	1.3	1.3	1.3	-1.3	-0.4
Delay disc. indifference point, 2s delay	0.9	1.0	1.8	1.1	-0.8	0.7	0.4	-0.8	-1.1	1.2	1.3	1.3	-1.3	-0.2
Delay disc. indifference point, 24s delay	0.8	0.8	2.1	0.6	-0.1	-0.1	0.9	-0.9	-0.9	0.9	0.9	0.9	-0.9	-1.4
Delay disc. indifference point, 4s delay	0.7	0.8	1.4	0.8	-0.5	0.3	0.5	-0.7	-1.0	1.0	1.2	1.2	-1.2	-0.8
Delay disc. indifference point, 8s delay	0.7	0.7	1.2	0.9	-0.6	0.5	0.5	-0.6	-0.9	0.9	1.1	1.1	-1.1	-0.7
Indifference point function ln k	0.2	0.3	1.4	0.0	-0.4	0.5	-1.1	0.1	0.3	-0.3	-0.5	-0.5	0.5	1.2
Indifference point function log k	0.2	0.3	1.4	0.0	-0.4	0.5	-1.1	0.1	0.3	-0.3	-0.5	-0.5	0.5	1.2
Patch foraging total patch changes 0 sec	0.1	0.2	1.3	0.0	-0.2	0.3	-1.1	0.1	0.1	-0.0	0.0	0.0	-0.0	0.7
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	-0.7	0.8	-0.8	0.5	0.6	0.4	-0.4	-0.2	-0.2	0.2	-0.5
Patch foraging total patch changes 18 sec	0.5	0.7	1.2	0.8	-0.8	0.8	-1.1	-0.7	-0.8	0.8	0.8	0.8	-0.8	0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3	-0.0	-0.1	0.1	0.2	0.2	-0.2	-0.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.5	0.2	-0.1	-0.3	0.7	0.5	-0.5	-0.4	-0.4	0.4	0.6
Patch foraging time to switch 0 sec	0.2	0.2	1.0	0.4	-0.6	0.7	-0.5	-0.3	-0.3	0.3	0.3	0.3	-0.3	1.0
Patch foraging water rate 0 sec	0.3	0.5	1.8	0.4	0.0	-0.2	0.1	-0.6	-0.7	0.7	0.8	0.8	-0.8	-1.3
Patch foraging water rate 12 sec	1.5	2.3	3.7	1.7	-1.4	1.3	-0.2	-1.4	-1.7	1.7	1.9	1.9	-1.9	-0.1
Patch foraging water rate 18 sec	1.4	1.9	2.7	1.6	-1.4	1.3	-0.9	-1.3	-1.5	1.5	1.6	1.6	-1.6	0.3
Patch foraging water rate 24 sec	0.9	1.3	1.9	1.4	-1.2	1.1	-1.1	-1.4	-1.3	1.2	1.1	1.1	-1.1	0.0
Patch foraging water rate 6 sec	1.2	1.8	2.9	1.4	-1.0	0.9	-0.1	-1.4	-1.6	1.6	1.7	1.7	-1.7	-0.4
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.3	-0.6	0.1	0.0	-0.6	0.9	1.0	-1.0	-1.1	-1.1	1.1	1.1
Distance traveled before self-admin	2.6	2.8	4.1	2.0	-1.8	1.8	-1.6	-1.6	-1.7	1.7	1.7	1.7	-1.7	0.6
Distance traveled after self-admin	0.5	0.6	1.2	0.7	-0.7	0.7	-1.0	-1.1	-0.9	0.8	0.6	0.6	-0.6	0.7
Extensor digitorum longus weight	0.3	1.0	2.7	0.7	-0.1	-0.0	0.8	-1.0	-1.1	1.1	1.2	1.2	-1.2	-1.6
Bone: elastic displacement	1.8	2.0	2.3	1.5	-1.5	1.5	-1.1	-1.5	-1.5	1.5	1.5	1.5	-1.5	1.0
Bone: elastic work	3.9	5.1	7.4	2.4	-2.7	2.7	-2.7	-1.9	-1.9	1.9	1.9	1.9	-1.9	2.5
Bone: endosteal estimation	0.4	1.0	4.0	0.6	-1.1	1.2	-1.9	0.0	0.0	-0.0	-0.0	-0.0	0.0	2.0
Bone: endosteal perimeter	0.1	0.2	0.6	-0.1	-0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.4	0.4	0.8
Epididymis fat weight	0.2	0.4	0.8	0.9	-0.9	0.8	-0.7	-0.3	-0.6	0.6	0.7	0.7	-0.7	-0.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.7	1.0	-1.3	1.3	-1.1	-0.4	-0.5	0.4	0.4	0.4	-0.4	1.0
Delta time in open arm before/after self-admin	0.3	0.2	1.1	-0.4	0.3	-0.3	0.8	1.1	0.5	-0.4	-0.0	-0.0	0.0	-0.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.2	0.3	-0.3	0.3	0.7	0.3	-0.3	-0.0	-0.0	0.0	-0.5
Delay discount exponential model param	1.6	1.7	2.8	-1.3	0.9	-0.7	-0.7	1.1	1.4	-1.5	-1.7	-1.7	1.7	0.9
Extinction: sum of active levers before priming	0.1	0.1	0.5	0.1	-0.2	0.3	-0.7	0.4	0.1	-0.1	0.1	0.1	-0.1	0.3
Active lever presses in extinction session 6	0.5	0.5	0.9	0.8	-0.6	0.5	0.1	-0.4	-0.7	0.8	1.0	1.0	-1.0	-0.5
Bone: final force	0.6	1.0	2.7	1.0	-1.2	1.2	-1.7	-0.6	-0.7	0.7	0.8	0.8	-0.8	1.3
Bone: final moment	0.9	1.4	3.4	1.2	-1.4	1.5	-1.9	-0.7	-0.8	0.8	0.9	0.9	-0.9	1.6
Food consumed during 24 hour testing period	1.1	1.4	4.0	1.2	-1.3	1.3	-2.0	-0.8	-0.9	0.9	0.9	0.9	-0.9	1.2
Glucose	3.9	5.9	7.8	2.7	-2.3	2.2	-1.1	-2.7	-2.8	2.8	2.8	2.8	-2.8	0.3
Heart weight	0.5	0.7	1.2	1.1	-1.1	1.0	-0.6	-0.6	-0.8	0.8	0.9	0.9	-0.9	0.1
Delay discount hyperbolic model param	1.4	1.5	2.6	-1.2	0.8	-0.6	-0.8	1.0	1.3	-1.4	-1.6	-1.6	1.6	0.9
Intermittent access intake day 1-15 change	1.6	1.6	2.8	1.1	-0.7	0.5	0.2	-1.3	-1.5	1.6	1.7	1.7	-1.7	-0.8
Intermittent access intake escalation	2.2	2.1	3.6	1.4	-1.1	0.9	-0.1	-1.5	-1.7	1.8	1.9	1.9	-1.9	-0.4
Intermittent access intake escalation 2	0.5	0.5	1.0	0.6	-0.4	0.3	0.1	-0.8	-0.9	0.9	1.0	1.0	-1.0	-0.3
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.7	-0.5	0.5	-0.6	0.6	0.3	0.5	-0.6	-0.8	-0.8	0.8	-0.8
Intermitt. access day 15 inactive lever presses	0.9	1.0	2.1	-1.0	0.8	-0.7	0.2	0.5	1.0	-1.1	-1.5	-1.5	1.5	0.2
Intermitt. access escalation Index	0.1	0.1	0.8	-0.0	-0.1	0.1	-0.2	0.9	0.3	-0.2	0.3	0.3	-0.3	0.1
Intermittent access day 1 total infusions	1.0	1.2	2.2	1.3	-1.2	1.2	-1.4	-1.5	-1.1	1.0	0.7	0.7	-0.7	0.7
Intermittent access day 15 total infusions	2.6	2.9	4.2	1.9	-1.5	1.4	-0.7	-2.1	-2.0	2.0	2.0	2.0	-2.0	-0.1
Intermittent access terminal intake (last 3 days)	4.7	5.2	7.8	2.5	-2.2	2.0	-1.6	-2.8	-2.6	2.6	2.4	2.4	-2.4	0.5
Intermittent access total infusions	3.2	3.6	5.0	2.2	-2.0	1.9	-1.6	-2.2	-2.1	2.0	1.9	1.9	-1.9	0.6
Intermittent access day 1 locomotion	0.2	0.2	0.7	0.6	-0.4	0.4	-0.4	-0.9	-0.6	0.5	0.3	0.3	-0.3	-0.2
Intermittent access day 15 total locomotion	3.4	3.7	5.0	2.2	-2.1	2.0	-1.5	-2.2	-2.1	2.0	1.9	1.9	-1.9	0.9
Intermittent access total locomotion	1.9	2.2	3.9	1.8	-1.6	1.5	-1.3	-2.0	-1.7	1.6	1.3	1.3	-1.3	0.3
Intermittent access standard deviation	0.2	0.3	0.7	-0.4	0.7	-0.7	0.1	-0.8	-0.2	0.1	-0.3	-0.3	0.3	-0.8
Left kidney weight	0.6	1.8	4.6	1.2	-1.6	1.7	-1.9	-0.5	-0.8	0.8	1.0	1.0	-1.0	2.2
Right kidney weight	0.4	1.1	2.8	1.0	-1.1	1.2	-1.7	-0.6	-0.8	0.8	1.0	1.0	-1.0	1.2
Cocaine induced anxiety	0.1	0.1	0.4	0.2	-0.3	0.4	-0.3	-0.3	-0.2	0.2	0.2	0.2	-0.2	0.6
Post-drug Anxiety	0.1	0.1	0.2	0.3	-0.3	0.3	-0.2	-0.5	-0.3	0.3	0.2	0.2	-0.2	0.3
Baseline Anxiety	0.0	0.0	0.2	0.2	-0.2	0.1	0.1	-0.2	-0.2	0.2	0.2	0.2	-0.2	-0.4
Tail length	3.3	10.0	12.5	3.5	-3.2	3.1	-2.7	-3.4	-3.4	3.4	3.4	3.4	-3.4	1.0
Length with tail	2.9	10.5	12.2	3.5	-3.3	3.2	-3.3	-3.5	-3.4	3.4	3.4	3.4	-3.4	1.5
Length without tail	0.6	1.3	2.3	1.1	-1.1	1.1	-1.5	-1.2	-1.1	1.1	1.0	1.0	-1.0	0.7
Times rat made contact with spout	0.2	0.2	1.4	0.1	-0.2	0.3	-1.2	-0.1	-0.1	0.1	0.0	0.0	-0.0	0.7
Lifetime Intake	2.7	3.1	4.2	2.0	-1.8	1.7	-1.6	-2.1	-1.9	1.9	1.8	1.8	-1.8	0.5
Liver weight, left	0.0	0.1	0.2	-0.1	0.1	-0.1	-0.5	0.3	0.3	-0.3	-0.2	-0.2	0.2	-0.1
Liver weight, right	0.4	0.7	1.0	0.9	-0.8	0.7	-0.6	-0.7	-0.9	0.9	1.0	1.0	-1.0	0.1
Locomotor activity	1.0	1.6	2.3	1.3	-1.3	1.2	-0.5	-1.3	-1.4	1.4	1.5	1.5	-1.5	0.8
Locomotor testing distance	1.5	2.5	3.1	1.6	-1.8	1.8	-0.8	-1.6	-1.6	1.6	1.7	1.7	-1.7	1.4
Locomotor testing rearing	0.4	0.6	3.1	-0.6	0.8	-0.8	1.7	0.6	0.4	-0.4	-0.3	-0.3	0.3	-0.9
Locomotion in novel chamber	2.1	2.5	4.4	-1.9	2.1	-2.1	1.2	1.3	1.5	-1.4	-1.5	-1.5	1.5	-1.2
Locomotion in novel chamber post-restriction	0.2	0.3	0.6	0.4	-0.1	-0.0	0.5	-0.7	-0.7	0.7	0.6	0.6	-0.6	-0.6
Fecal boli incidents, locomotor time 1	0.4	0.4	2.2	0.1	0.3	-0.5	1.0	-0.5	-0.4	0.4	0.4	0.4	-0.4	-1.5
Change in fecal boli incidents, locomotor task	0.6	0.6	3.9	0.2	-0.7	0.8	-1.0	-0.1	0.0	-0.0	-0.1	-0.1	0.1	2.0
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.6	-1.1	1.0	-1.0	0.5	1.3	1.1	-1.1	-0.9	-0.9	0.9	-0.3
Bouts of movement, locomotor time 1	0.3	0.3	0.8	-0.5	0.5	-0.5	0.9	0.5	0.5	-0.5	-0.5	-0.5	0.5	-0.3
Total resting periods, locomotor time 1	0.4	0.4	0.9	-0.6	0.6	-0.6	0.9	0.7	0.7	-0.7	-0.6	-0.6	0.6	-0.4
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.4	0.5	-0.5	0.0	0.4	0.5	-0.5	-0.6	-0.6	0.6	-0.6
Distance moved, locomotor task time 1	0.9	1.0	1.3	1.1	-1.1	1.1	-0.6	-0.9	-1.0	1.0	1.0	1.0	-1.0	0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2	0.1	0.1	-0.1	-0.1	-0.1	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.8	-0.5	0.8	-0.9	1.3	0.3	0.3	-0.3	-0.2	-0.2	0.2	-1.3
Bouts of movement, locomotor time 2	0.6	0.6	2.1	-0.7	1.0	-1.0	1.0	0.3	0.4	-0.4	-0.5	-0.5	0.5	-1.4
Total resting periods, locomotor time 2	0.6	0.6	1.9	-0.7	1.0	-1.0	0.9	0.3	0.5	-0.5	-0.6	-0.6	0.6	-1.4
Rest time, locomotor task time 2	0.2	0.2	0.3	-0.5	0.5	-0.5	0.3	0.2	0.4	-0.4	-0.4	-0.4	0.4	-0.4
Distance moved, locomotor task time 2	0.5	0.6	1.9	0.7	-1.0	1.1	-0.6	-0.3	-0.4	0.4	0.5	0.5	-0.5	1.4
Vertical activity count, locomotor time 2	1.7	1.8	2.7	-1.4	1.1	-1.0	0.8	1.7	1.6	-1.6	-1.6	-1.6	1.6	0.0
Light reinforcement 1	1.1	2.0	4.3	1.4	-0.9	0.7	0.2	-2.1	-1.8	1.8	1.5	1.5	-1.5	-1.0
Light reinforcement 2	2.5	3.3	5.2	1.9	-1.8	1.7	-1.3	-2.3	-2.1	2.0	1.9	1.9	-1.9	0.7
Bone: marrow area	0.5	1.0	4.2	0.6	-1.1	1.3	-1.9	0.0	-0.0	0.0	0.0	0.0	-0.0	2.0
Bone: maximum diameter	0.5	0.9	3.2	0.8	-1.1	1.2	-1.7	-0.2	-0.3	0.3	0.4	0.4	-0.4	1.8
Bone: maximum force	1.4	2.4	6.9	1.4	-1.9	2.0	-2.6	-0.7	-0.8	0.8	0.8	0.8	-0.8	2.6
Bone: maximum moment	1.7	3.0	8.4	1.5	-2.1	2.2	-2.8	-0.9	-0.9	0.9	0.9	0.9	-0.9	2.9
Mean time between licks in bursts	0.5	0.7	1.1	-0.9	1.0	-1.0	0.7	0.7	0.7	-0.7	-0.7	-0.7	0.7	-1.0
Mean num. licks in bursts	0.2	0.2	1.7	-0.2	0.1	-0.0	-1.3	-0.1	0.1	-0.1	-0.2	-0.2	0.2	0.6
Cd content in liver	3.2	3.5	4.6	2.0	-1.8	1.8	-1.0	-2.1	-2.1	2.1	2.1	2.1	-2.1	0.7
Co content in liver	0.1	0.1	0.1	0.3	-0.3	0.3	-0.0	-0.3	-0.3	0.3	0.4	0.4	-0.4	0.2
Cu content in liver	0.7	0.8	3.5	0.8	-1.3	1.4	-1.0	0.2	-0.0	0.0	0.2	0.2	-0.2	1.9
Fe content in liver	1.1	1.3	1.7	1.3	-1.3	1.3	-1.2	-1.1	-1.1	1.1	1.1	1.1	-1.1	0.8
K content in liver	1.0	1.0	5.3	-0.4	1.0	-1.1	1.8	0.2	-0.1	0.1	0.3	0.3	-0.3	-2.3
Mg content in liver	0.8	0.8	3.4	-0.3	0.8	-0.9	1.9	0.4	0.1	-0.0	0.2	0.2	-0.2	-1.8
Mn content in liver	0.2	0.2	0.9	-0.4	0.4	-0.4	0.9	0.5	0.3	-0.3	-0.2	-0.2	0.2	-0.4
Na content in liver	0.1	0.1	0.5	0.2	-0.2	0.2	-0.7	-0.1	-0.2	0.2	0.2	0.2	-0.2	0.2
Rb content in liver	1.0	1.2	2.1	0.9	-0.3	0.1	0.9	-0.9	-1.2	1.2	1.4	1.4	-1.4	-1.4
Se content in liver	0.0	0.1	0.2	0.2	-0.3	0.3	-0.1	-0.4	-0.2	0.2	0.1	0.1	-0.1	0.4
Sr content in liver	0.1	0.1	0.4	0.1	0.0	-0.1	0.6	-0.3	-0.3	0.3	0.3	0.3	-0.3	-0.5
Zn content in liver	0.6	0.6	1.6	0.4	-0.0	-0.1	1.1	-0.5	-0.7	0.8	0.9	0.9	-0.9	-1.3
Bone: minimum diameter	0.5	0.9	4.0	0.7	-1.2	1.3	-1.3	-0.1	-0.2	0.2	0.2	0.2	-0.2	2.0
Time in familiar zone, hab. session 1	2.8	2.6	4.1	-1.6	1.1	-1.0	-0.3	1.9	2.0	-2.0	-2.0	-2.0	2.0	0.8
Time in novel zone, hab. session 1	5.3	5.2	7.8	2.4	-2.0	1.8	-0.2	-2.5	-2.7	2.7	2.8	2.8	-2.8	-0.0
Total zone transitions, hab. session 1	0.5	0.6	0.9	0.8	-0.5	0.4	-0.1	-0.9	-0.9	0.9	1.0	1.0	-1.0	-0.8
Total locomotion distance, hab. session 1	0.2	0.4	0.5	-0.6	0.7	-0.7	0.1	0.4	0.5	-0.6	-0.7	-0.7	0.7	-0.6
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.6	0.7	-0.7	-0.2	0.6	0.6	-0.6	-0.7	-0.7	0.7	-0.6
Time in familiar zone, hab. session 2	1.0	1.0	1.4	-1.2	1.2	-1.2	0.6	0.9	1.1	-1.0	-1.1	-1.1	1.1	-0.4
Time in novel zone, hab. session 2	2.4	2.4	3.9	1.8	-2.0	2.0	-1.4	-1.3	-1.4	1.4	1.4	1.4	-1.4	1.4
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.2	0.4	-0.4	-0.0	-0.0	0.1	-0.1	-0.2	-0.2	0.2	-0.6
Total locomotion distance, hab. session 2	1.4	1.8	2.4	-1.5	1.5	-1.5	0.2	1.2	1.4	-1.4	-1.5	-1.5	1.5	-0.7
Locomotion velocity, hab. session 2	2.0	2.7	3.5	-1.8	1.8	-1.7	0.2	1.6	1.8	-1.8	-1.9	-1.9	1.9	-0.7
Novel to familiar place preference ratio	0.6	0.6	1.8	0.7	-1.0	1.1	-1.2	-0.1	-0.2	0.2	0.3	0.3	-0.3	1.3
Novelty place preference	0.9	0.9	2.7	0.9	-1.3	1.3	-1.4	-0.3	-0.4	0.4	0.5	0.5	-0.5	1.6
Time in novel zone, NPP test	0.8	0.9	2.0	0.9	-1.2	1.3	-1.2	-0.4	-0.5	0.5	0.6	0.6	-0.6	1.4
Total zone transitions, NPP test	0.1	0.1	0.5	0.1	0.1	-0.2	-0.2	-0.3	-0.3	0.3	0.2	0.2	-0.2	-0.7
Total locomotion distance, NPP test	0.5	0.7	2.3	-0.8	1.1	-1.2	0.7	0.5	0.5	-0.5	-0.6	-0.6	0.6	-1.5
Locomotion velocity, NPP test	0.5	0.8	1.8	-0.9	1.1	-1.1	0.5	0.7	0.7	-0.7	-0.7	-0.7	0.7	-1.3
Intraocular pressure	0.3	0.4	1.8	0.3	-0.7	0.8	-1.0	0.3	0.2	-0.2	-0.1	-0.1	0.1	1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.8	-0.2	-0.1	0.1	-0.3	-0.0	0.0	-0.0	-0.0	-0.0	0.0	0.9
Delta ambulatory time before/after self-admin	0.1	0.1	0.8	0.1	-0.2	0.3	-0.3	-0.3	-0.2	0.3	0.2	0.2	-0.2	0.9
Parametrial fat weight	1.7	3.3	4.4	2.1	-1.9	1.8	-1.3	-2.0	-2.0	2.0	1.9	1.9	-1.9	0.3
Pavlov. Cond. lever latency	1.9	2.5	3.1	1.7	-1.5	1.5	-1.1	-1.6	-1.7	1.7	1.8	1.8	-1.8	0.6
Pavlov. Cond. magazine entry latency	1.5	2.0	3.0	-1.4	1.0	-0.9	0.3	1.7	1.7	-1.7	-1.7	-1.7	1.7	0.3
Pavlov. Cond. change in total contacts	2.3	2.4	3.0	-1.7	1.6	-1.6	1.2	1.7	1.7	-1.7	-1.7	-1.7	1.7	-0.7
Pavlov. Cond. index score	2.3	3.0	4.1	-1.8	1.5	-1.4	0.8	1.9	2.0	-2.0	-2.0	-2.0	2.0	-0.2
Pavlov. Cond. latency score	1.6	2.1	3.0	-1.5	1.2	-1.1	0.5	1.7	1.7	-1.7	-1.7	-1.7	1.7	0.0
Pavlov. Cond. lever contacts	1.1	1.3	1.8	-1.2	0.9	-0.9	0.5	1.3	1.3	-1.3	-1.4	-1.4	1.4	-0.0
Pavlov. Cond. magazine entry number	2.9	3.6	5.1	2.0	-1.7	1.6	-0.9	-2.2	-2.2	2.2	2.2	2.2	-2.2	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.1	-0.0	0.1	-0.6	0.0	0.1	-0.2	-0.2	-0.2	0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	4.8	-2.1	1.8	-1.7	1.1	2.1	2.2	-2.2	-2.2	-2.2	2.2	-0.5
Pavlov. Cond. response bias	1.8	2.2	2.9	-1.6	1.4	-1.3	0.8	1.6	1.7	-1.7	-1.7	-1.7	1.7	-0.3
Pavlov. Cond. lever latency	3.0	4.0	7.4	2.0	-2.4	2.5	-2.7	-1.7	-1.6	1.6	1.5	1.5	-1.5	2.6
Pavlov. Cond. magazine entry latency	2.5	2.9	3.8	-1.9	2.0	-1.9	1.3	1.6	1.7	-1.7	-1.7	-1.7	1.7	-1.3
Pavlov. Cond. change in total contacts	2.5	3.5	7.2	-1.8	2.3	-2.4	2.6	1.3	1.3	-1.3	-1.3	-1.3	1.3	-2.7
Pavlov. Cond. index score	3.2	4.1	5.9	-2.1	2.4	-2.4	2.3	1.8	1.8	-1.8	-1.8	-1.8	1.8	-2.2
Pavlov. Cond. latency score	3.3	4.1	5.5	-2.1	2.3	-2.3	2.1	1.8	1.9	-1.9	-1.9	-1.9	1.9	-1.9
Pavlov. Cond. lever contacts	2.6	3.5	5.6	-1.9	2.2	-2.3	2.4	1.7	1.6	-1.6	-1.5	-1.5	1.5	-2.2
Pavlov. Cond. magazine entry number	5.0	6.1	8.0	2.7	-2.8	2.8	-2.2	-2.3	-2.4	2.4	2.4	2.4	-2.4	2.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.4	-1.1	1.2	-1.2	1.0	1.0	1.0	-1.0	-0.9	-0.9	0.9	-1.1
Pavlov. Cond. lever-magazine prob. diff.	3.5	4.5	6.7	-2.2	2.5	-2.6	2.5	1.8	1.8	-1.8	-1.8	-1.8	1.8	-2.4
Pavlov. Cond. response bias	4.2	5.6	8.9	-2.4	2.9	-3.0	3.0	2.0	1.9	-1.9	-1.8	-1.8	1.8	-3.0
Time in closed arm before self-admin	0.3	0.4	1.0	-0.7	0.8	-0.8	1.0	0.4	0.4	-0.4	-0.4	-0.4	0.4	-0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	-0.3	0.3	0.2	-0.3	-0.4	0.4	0.4	0.4	-0.4	-0.3
Time in open arm before self-admin	0.4	0.4	1.1	0.5	-0.6	0.6	-1.0	-0.7	-0.5	0.5	0.3	0.3	-0.3	0.9
Time in open arm after self-admin	0.5	0.5	2.0	-0.8	0.4	-0.3	0.5	1.4	0.9	-0.8	-0.5	-0.5	0.5	0.7
Bone: periosteal estimation	1.3	2.7	8.9	1.4	-2.1	2.2	-2.7	-0.6	-0.7	0.7	0.7	0.7	-0.7	3.0
Bone: periosteal perimeter	0.3	0.4	2.1	0.3	-0.7	0.8	-1.1	0.2	0.1	-0.1	-0.1	-0.1	0.1	1.5
Bone: post-yield work	0.1	0.1	0.3	0.3	-0.2	0.1	0.1	-0.6	-0.4	0.4	0.3	0.3	-0.3	-0.5
Progressive ratio test 1 active lever presses	1.2	1.3	1.7	1.3	-1.3	1.3	-1.2	-1.1	-1.1	1.1	1.1	1.1	-1.1	0.9
Progressive ratio test 1 breakpoint	1.4	1.4	1.9	1.4	-1.3	1.3	-1.1	-1.2	-1.2	1.2	1.2	1.2	-1.2	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.5	-0.5	0.5	-0.0	-0.6	-0.4	0.3	0.2	0.2	-0.2	0.1
Progressive ratio test 2 active lever presses	3.6	3.9	5.0	2.2	-2.1	2.0	-1.6	-2.2	-2.1	2.1	2.0	2.0	-2.0	1.1
Progressive ratio test 2 breakpoint	2.7	3.0	3.9	1.9	-1.8	1.7	-1.2	-2.0	-1.9	1.9	1.8	1.8	-1.8	0.8
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.6	0.9	-0.7	0.7	-0.4	-1.3	-0.9	0.9	0.6	0.6	-0.6	0.0
Incentive Sensitization - Responses	2.2	2.3	3.4	1.6	-1.5	1.5	-1.7	-1.9	-1.6	1.5	1.3	1.3	-1.3	1.2
Incentive Sensitization - Breakpoint	1.9	2.0	3.1	1.4	-1.4	1.4	-1.6	-1.7	-1.5	1.4	1.2	1.2	-1.2	1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	-0.3	0.2	-0.5	-0.4	-0.4	0.4	0.3	0.3	-0.3	-0.0
Progressive ratio	3.4	4.0	5.2	-2.1	2.3	-2.3	1.9	1.5	1.8	-1.9	-2.1	-2.1	2.1	-1.8
Food seeking constrained by brief footshock	1.4	1.7	3.6	1.3	-1.5	1.5	-1.9	-1.3	-1.1	1.1	1.0	1.0	-1.0	1.5
Seeking ratio, punishment vs. effort	4.5	5.4	7.9	2.4	-2.6	2.7	-2.8	-1.9	-2.1	2.1	2.2	2.2	-2.2	2.3
Retroperitoneal fat weight	0.7	2.3	3.4	1.4	-0.7	0.5	0.3	-1.7	-1.8	1.8	1.8	1.8	-1.8	-1.8
Reaction time number correct	0.3	0.5	0.6	0.7	-0.6	0.6	-0.6	-0.7	-0.8	0.8	0.8	0.8	-0.8	0.0
Reaction time mean minus median	0.4	0.6	3.2	-0.4	0.6	-0.7	1.8	0.7	0.3	-0.2	0.1	0.1	-0.1	-1.2
Reaction time mean minus median AUC	0.5	0.7	3.0	0.1	0.3	-0.4	1.7	0.1	-0.4	0.4	0.7	0.7	-0.7	-1.4
Reaction time num false alarms	0.6	0.8	1.1	-1.0	1.1	-1.1	0.8	0.7	0.8	-0.8	-0.9	-0.9	0.9	-0.8
Reaction time num false alarms AUC	0.2	0.3	0.4	-0.6	0.7	-0.7	0.3	0.3	0.4	-0.5	-0.6	-0.6	0.6	-0.4
Reaction time trials correct on left	0.3	0.5	0.6	0.7	-0.6	0.6	-0.6	-0.7	-0.8	0.8	0.8	0.8	-0.8	0.0
Reaction time trials on left	0.3	0.5	0.7	0.7	-0.6	0.5	-0.6	-0.7	-0.8	0.8	0.8	0.8	-0.8	-0.0
Reaction time mean	0.8	1.1	2.5	-1.0	1.0	-1.1	1.6	1.4	1.0	-1.0	-0.7	-0.7	0.7	-0.9
Reaction time mean AUC	0.8	1.1	2.1	-1.0	1.0	-1.0	1.5	1.4	1.1	-1.1	-0.8	-0.8	0.8	-0.8
Median of all reaction times	0.8	1.1	1.9	-1.1	1.0	-0.9	1.1	1.4	1.1	-1.1	-1.0	-1.0	1.0	-0.5
Reaction time omissions	0.7	0.9	3.5	-0.7	1.0	-1.1	1.6	0.5	0.5	-0.5	-0.4	-0.4	0.4	-1.9
Reaction time false alarm rate	0.3	0.4	0.6	-0.8	0.8	-0.8	0.6	0.5	0.6	-0.6	-0.7	-0.7	0.7	-0.4
Reaction time premature initiation rate	3.0	4.0	7.2	1.9	-1.2	1.0	-0.3	-2.7	-2.5	2.5	2.4	2.4	-2.4	-0.9
Reaction time premature initiations	2.9	4.0	6.9	1.9	-1.2	1.0	-0.4	-2.6	-2.5	2.5	2.4	2.4	-2.4	-0.9
Std. dev. reaction times	0.8	1.1	4.0	-0.9	1.0	-1.1	2.0	1.3	0.8	-0.8	-0.5	-0.5	0.5	-1.3
Reaction time trials completed	0.3	0.5	0.7	0.7	-0.6	0.5	-0.6	-0.7	-0.8	0.8	0.8	0.8	-0.8	-0.0
Reaction time trials AUC	0.4	0.6	0.8	0.8	-0.7	0.6	-0.6	-0.8	-0.8	0.9	0.9	0.9	-0.9	0.0
Run reversals in cocaine runway, females	1.8	1.8	2.5	-1.6	1.5	-1.5	0.8	1.4	1.4	-1.4	-1.3	-1.3	1.3	-0.8
Run reversals in cocaine runway, males	2.3	2.3	3.6	1.5	-1.5	1.5	-1.9	-1.4	-1.4	1.5	1.5	1.5	-1.5	1.3
Latency to leave start box in cocaine runway	7.3	7.9	10.1	-3.0	2.6	-2.5	2.3	3.0	3.1	-3.1	-3.2	-3.2	3.2	-0.7
Latency to leave start box in cocaine runway, F	3.3	3.7	4.2	-2.0	1.9	-1.8	2.0	2.0	2.0	-2.0	-2.0	-2.0	2.0	-1.1
Latency to leave start box in cocaine runway, M	3.2	3.1	4.5	-1.9	1.6	-1.5	1.2	1.7	1.9	-2.0	-2.1	-2.1	2.1	-0.1
Std. dev. time between licks in bursts	3.8	4.6	6.9	-2.3	2.6	-2.6	2.5	1.8	1.8	-1.8	-1.8	-1.8	1.8	-2.3
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	-0.3	0.3	-0.3	-0.5	-0.4	0.4	0.3	0.3	-0.3	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.6	0.1	-0.3	0.4	-0.6	0.1	0.1	-0.2	-0.2	-0.2	0.2	0.8
Short access day 10 total inactive lever presses	1.1	1.2	1.6	-1.1	1.2	-1.2	1.3	1.0	1.1	-1.1	-1.1	-1.1	1.1	-1.0
Short access day 1 total infusions	0.5	0.6	3.2	0.6	-0.7	0.7	-1.8	-0.5	-0.4	0.4	0.3	0.3	-0.3	0.9
Short access day 10 total infusions	2.6	2.9	4.5	1.9	-1.7	1.7	-1.7	-2.1	-1.9	1.8	1.6	1.6	-1.6	0.4
Short access total infusions	1.2	1.4	1.9	1.4	-1.2	1.1	-0.9	-1.2	-1.3	1.3	1.3	1.3	-1.3	0.2
Short access day 1 locomotion	1.8	1.9	2.6	1.6	-1.5	1.4	-1.4	-1.3	-1.4	1.4	1.5	1.5	-1.5	0.6
Short access day 10 total locomotion	0.2	0.2	1.2	-0.1	0.4	-0.5	-0.3	-0.4	0.0	-0.1	-0.5	-0.5	0.5	-1.1
Short access total locomotion	1.0	1.1	1.6	1.3	-1.0	1.0	-0.9	-1.1	-1.1	1.1	1.1	1.1	-1.1	-0.1
One hour access (0.3 mA shock)	2.3	2.7	4.0	1.8	-1.4	1.3	-1.2	-2.0	-1.9	1.9	1.8	1.8	-1.8	-0.1
Compulsive drug intake	2.5	2.5	3.4	-1.8	1.8	-1.7	0.8	1.3	1.6	-1.6	-1.9	-1.9	1.9	-0.8
One hour access (shock baseline)	5.9	6.9	8.9	3.0	-2.7	2.6	-2.0	-2.8	-2.9	2.9	2.8	2.8	-2.8	0.7
Social response proportion	0.2	0.2	0.6	-0.5	0.6	-0.7	0.8	0.4	0.4	-0.3	-0.3	-0.3	0.3	-0.5
Social responses	0.4	0.5	2.8	0.1	0.4	-0.6	0.9	-0.6	-0.6	0.6	0.5	0.5	-0.5	-1.7
Social time	3.6	4.8	7.9	-2.3	2.4	-2.4	2.8	2.3	2.1	-2.0	-1.9	-1.9	1.9	-1.8
Soleus weight	7.4	21.7	26.8	5.1	-4.6	4.4	-3.1	-5.1	-5.2	5.2	5.2	5.2	-5.2	1.4
Bone: stiffness	0.3	0.4	1.7	-0.2	-0.2	0.3	-1.1	0.6	0.6	-0.5	-0.5	-0.5	0.5	1.3
Tibialis anterior weight	0.0	0.1	0.5	-0.1	0.3	-0.3	0.7	-0.1	-0.0	0.0	-0.0	-0.0	0.0	-0.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.3	0.0	-0.1	-0.6	-0.6	-0.5	0.5	0.5	0.5	-0.5	-0.7
Time to tail flick, vehicle, after self-admin	0.6	0.7	0.8	-0.9	0.9	-0.8	-0.0	0.9	0.9	-0.9	-0.9	-0.9	0.9	-0.3
Time to tail flick, test, before self-admin	1.0	1.0	1.3	1.1	-1.2	1.1	-1.2	-1.0	-1.0	0.9	0.9	0.9	-0.9	0.6
Time to tail flick, test, after self-admin	1.1	1.1	2.3	1.3	-1.5	1.5	-1.0	-1.0	-0.9	0.8	0.7	0.7	-0.7	1.0
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.8	-1.1	0.7	-0.6	0.5	1.7	1.5	-1.5	-1.4	-1.4	1.4	0.4
Delta time to tail flick, test, before/after SA	0.3	0.2	0.8	0.7	-0.9	0.9	-0.1	-0.1	-0.3	0.2	0.3	0.3	-0.3	0.5
Tibia length	0.6	1.6	6.0	0.9	-1.4	1.6	-2.4	-0.2	-0.3	0.3	0.3	0.3	-0.3	2.4
Ambulatory time before self-admin	3.4	3.6	4.7	2.2	-1.9	1.7	-1.4	-2.0	-2.1	2.1	2.1	2.1	-2.1	0.2
Ambulatory time after self-admin	1.0	1.1	2.0	1.1	-1.0	1.0	-0.9	-1.4	-1.2	1.2	1.0	1.0	-1.0	0.4
Bone: tissue strength	6.2	6.0	7.8	2.6	-2.3	2.2	-1.8	-2.8	-2.8	2.8	2.7	2.7	-2.7	0.6
Total heroin consumption	0.5	0.5	1.9	0.7	-0.8	0.9	-1.4	-0.7	-0.5	0.4	0.2	0.2	-0.2	0.9
Bone: trabecular number	0.0	0.0	0.3	0.0	-0.2	0.2	-0.3	0.1	0.1	-0.1	-0.1	-0.1	0.1	0.6
Bone: trabecular spacing	0.6	0.7	3.9	-0.5	0.9	-1.1	1.4	0.0	0.1	-0.1	-0.1	-0.1	0.1	-2.0
Bone: trabecular thickness	2.6	3.1	6.2	1.8	-2.1	2.2	-2.3	-1.2	-1.3	1.3	1.3	1.3	-1.3	2.5
Bone: trabecular tissue density	0.3	0.5	1.4	0.6	-0.9	0.9	-0.9	-0.4	-0.4	0.4	0.4	0.4	-0.4	1.2
Water consumed over 24 hours	0.2	0.3	1.3	-0.2	-0.1	0.2	-1.1	0.3	0.3	-0.3	-0.4	-0.4	0.4	1.1
Number of responses in last shaping day	0.2	0.2	1.1	-0.3	0.2	-0.1	-1.1	0.3	0.3	-0.3	-0.4	-0.4	0.4	0.1