Hub : Genes

Slco2a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Slco2a1 0.07 0.05 4.3e-03 0.01 0.01 0.01 0.01 6.1e-02 1.4e-02 1.1e-02 2.1e-02
2 Liver alternative TSS NM_022667.3 0.14 0.08 2.5e-10 0.08 0.07 0.06 0.08 2.5e-09 1.3e-08 1.0e-07 7.9e-09
3 Liver alternative TSS XM_039080798.2 0.16 0.08 1.0e-10 0.08 0.07 0.07 0.07 3.3e-09 2.6e-08 7.8e-08 2.1e-08
4 Liver isoform ratio XM_039080798.2 0.08 0.05 2.2e-04 0.02 0.01 0.02 0.01 8.8e-04 8.4e-03 1.1e-03 8.5e-03
5 Liver intron excision ratio chr8_112516215_112533413 0.09 0.06 3.2e-05 0.03 0.02 0.02 0.02 9.2e-05 3.5e-03 1.8e-03 1.1e-03
6 Liver intron excision ratio chr8_112520573_112533413 0.08 0.05 1.0e-03 0.01 0.01 0.01 0.01 3.6e-02 3.2e-02 2.3e-02 2.2e-02
7 Adipose gene expression Slco2a1 0.1 0.07 6.7e-05 0.03 0.03 0.02 0.03 1.3e-04 1.6e-04 1.7e-03 2.8e-04
8 NAcc alternative TSS XM_039080798.2 0.03 0.02 9.8e-04 0.03 0.02 0.03 0.03 4.6e-05 6.4e-04 8.0e-05 9.3e-05
9 Liver alternative TSS XM_006243655.4 0.28 0.11 0.0e+00 0.16 0.16 0.16 0.16 1.9e-17 2.2e-17 2.6e-17 1.8e-17
10 Liver alternative TSS NM_022667.3 0.25 0.11 0.0e+00 0.15 0.15 0.15 0.15 4.0e-16 4.6e-16 5.7e-16 5.9e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.10.2-0.50.0-0.0-0.40.40.40.40.10.20.0
Area under the delay curve1.62.53.4-1.31.8-1.8-1.61.61.61.0-1.81.61.6
BMI with tail0.93.24.6-1.32.1-2.1-1.61.61.61.4-2.11.81.9
BMI without tail3.518.523.3-4.14.6-4.6-3.93.94.03.8-4.84.44.7
Body weight3.917.318.1-4.24.1-4.1-4.24.24.24.1-4.14.24.1
Weight adjusted by age0.10.31.5-1.20.5-0.5-0.30.30.30.9-0.40.40.4
Bone surface0.91.72.20.9-1.51.51.2-1.2-1.2-1.31.5-1.3-1.4
Bone volume0.20.40.90.3-0.80.80.5-0.5-0.5-0.50.9-0.6-0.7
Breakpoint value in progressive ratio session0.10.30.60.0-0.30.30.8-0.8-0.7-0.50.5-0.4-0.1
Number of licking bursts0.00.10.2-0.20.5-0.5-0.30.30.30.2-0.40.40.5
Context. condit. distance diff. score3.54.26.7-2.11.7-1.7-2.22.22.22.6-1.81.91.7
Locomotion velocity, session 10.10.10.4-0.60.2-0.2-0.30.30.30.4-0.10.20.2
Locomotion distance, session 10.00.00.2-0.40.2-0.2-0.10.10.10.1-0.00.20.2
Locomotion velocity, session 20.00.00.1-0.2-0.30.3-0.10.10.00.30.3-0.1-0.2
Locomotion distance, session 20.10.10.4-0.60.3-0.3-0.20.20.10.2-0.20.20.2
Locomotion velocity, session 30.10.20.4-0.40.6-0.60.1-0.1-0.10.3-0.60.20.4
Locomotion distance, session 30.30.40.60.6-0.40.40.8-0.8-0.8-0.70.5-0.6-0.5
Stereotopy head waving bouts, day 30.00.10.10.2-0.20.20.3-0.3-0.3-0.20.1-0.2-0.1
Stereotopy head waving duration, day 30.00.00.0-0.10.0-0.00.1-0.1-0.0-0.1-0.10.10.2
Locomotion velocity, session 70.20.20.2-0.40.4-0.4-0.50.50.40.4-0.40.40.3
Locomotion distance, session 70.00.10.20.1-0.20.2-0.00.0-0.1-0.00.3-0.3-0.5
Stereotopy head waving bouts, day 70.10.10.30.6-0.30.30.4-0.4-0.4-0.30.3-0.2-0.1
Stereotopy head waving duration, day 70.00.00.10.30.0-0.00.2-0.2-0.2-0.20.00.10.2
Locomotion velocity, session 82.02.53.1-1.61.6-1.6-1.51.51.41.8-1.61.51.5
Locomotion distance, session 82.53.75.9-2.21.7-1.7-2.02.01.92.4-1.71.71.5
Degree of sensitization distance0.30.30.6-0.50.4-0.4-0.80.80.80.7-0.40.50.3
Degree of sensitization stereotypy0.00.00.10.1-0.00.0-0.00.0-0.00.00.10.10.2
Conditioned locomotion0.40.40.60.5-0.60.60.8-0.8-0.7-0.60.6-0.7-0.6
Cocaine response after cond. corrected0.20.30.4-0.30.4-0.4-0.70.70.60.5-0.40.50.4
Cocaine response after cond. not corrected0.40.60.9-0.50.7-0.7-1.01.00.90.8-0.60.80.6
Cocaine response before conditioning0.20.30.4-0.60.5-0.5-0.60.60.50.7-0.50.50.4
Saline control response1.11.62.4-1.11.4-1.4-1.11.11.11.0-1.51.31.4
Bone: connectivity density0.00.00.1-0.30.1-0.1-0.20.20.20.2-0.10.1-0.0
Bone: cortical apparent density0.71.11.51.2-1.21.20.9-0.9-0.9-1.01.2-0.9-0.9
Bone: cortical area0.40.71.0-1.00.8-0.8-0.90.90.90.7-0.60.90.9
Bone: cortical porosity0.30.40.60.4-0.50.50.8-0.8-0.7-0.80.6-0.5-0.4
Bone: cortical porosity0.20.30.50.3-0.40.40.6-0.6-0.6-0.70.5-0.4-0.3
Bone: cortical thickness1.01.61.9-1.21.2-1.2-1.41.41.41.3-1.01.31.3
Bone: cortical thickness0.00.00.1-0.30.1-0.1-0.20.20.30.1-0.00.30.3
Bone: cortical tissue density0.71.11.41.2-1.21.20.9-0.9-0.9-1.01.2-0.9-0.9
Condit. Reinf. active minus inactive responses0.10.10.4-0.30.3-0.3-0.40.40.40.6-0.30.30.3
Condit. Reinf. active-inactive response ratio1.21.31.6-1.11.1-1.1-1.21.21.21.3-1.11.21.1
Condit. Reinf. active responses0.00.00.10.1-0.00.0-0.00.00.00.30.0-0.0-0.1
Condit. Reinf. inactive responses0.30.40.70.7-0.70.70.6-0.6-0.6-0.50.7-0.7-0.8
Incentive salience index mean0.00.00.10.3-0.00.00.2-0.2-0.2-0.00.0-0.2-0.2
Condit. Reinf. lever presses0.30.40.60.8-0.40.40.7-0.7-0.7-0.70.4-0.6-0.5
Condit. Reinf. active minus inactive responses0.81.32.51.2-1.11.11.0-1.0-1.0-1.61.0-1.1-1.1
Condit. Reinf. active-inactive response ratio0.10.20.3-0.40.4-0.4-0.50.50.50.1-0.50.50.4
Condit. Reinf. active responses1.82.63.41.6-1.51.51.6-1.6-1.6-1.81.6-1.6-1.6
Condit. Reinf. inactive responses4.26.26.82.6-2.42.42.6-2.6-2.6-2.22.6-2.5-2.5
Condit. Reinf. lever presses0.91.31.81.4-1.11.11.0-1.0-1.0-1.21.1-1.1-1.2
Condit. Reinf. lever reinforcers received1.72.33.21.6-1.41.41.6-1.6-1.6-1.81.4-1.5-1.4
Conditioned reinforcement - actives0.62.53.1-1.81.6-1.6-1.61.61.61.7-1.51.51.4
Conditioned reinforcement - inactives0.10.20.40.10.4-0.4-0.60.60.50.2-0.30.30.2
Conditioned locomotion0.60.91.9-1.41.1-1.1-0.60.60.60.7-1.10.81.0
Patch foraging indifference point 0 sec0.10.20.7-0.80.3-0.3-0.40.40.40.3-0.20.30.3
Patch foraging indifference point AUC0.00.10.40.3-0.20.2-0.10.10.1-0.60.3-0.2-0.4
Delay disc. indifference point, 0s delay0.70.81.3-0.91.1-1.1-0.60.60.70.4-1.10.91.0
Delay disc. indifference point, 16s delay1.11.62.1-1.11.4-1.4-1.21.21.21.0-1.41.31.3
Delay disc. indifference point, 2s delay1.61.82.4-1.21.5-1.5-1.21.21.30.9-1.61.31.3
Delay disc. indifference point, 24s delay0.60.91.1-0.81.0-1.0-1.01.01.00.8-1.00.90.9
Delay disc. indifference point, 4s delay1.01.01.5-0.71.2-1.2-1.11.11.00.6-1.21.00.9
Delay disc. indifference point, 8s delay0.71.21.7-0.91.3-1.3-1.01.01.10.5-1.21.21.2
Indifference point function ln k0.10.20.40.5-0.30.30.6-0.6-0.5-0.20.3-0.3-0.1
Indifference point function log k0.10.20.40.5-0.30.30.6-0.6-0.5-0.20.3-0.3-0.1
Patch foraging total patch changes 0 sec0.00.00.2-0.5-0.00.0-0.10.10.1-0.10.20.00.0
Patch foraging total patch changes 12 sec0.10.10.20.2-0.30.3-0.10.10.1-0.50.5-0.2-0.5
Patch foraging total patch changes 18 sec0.41.02.2-1.50.6-0.6-1.21.21.20.9-0.60.90.7
Patch foraging total patch changes 24 sec0.00.10.3-0.20.1-0.1-0.50.50.50.20.00.30.2
Patch foraging total patch changes 6 sec0.10.10.20.3-0.30.30.2-0.2-0.2-0.50.3-0.4-0.5
Patch foraging time to switch 0 sec0.00.00.1-0.2-0.00.0-0.10.10.10.3-0.20.20.2
Patch foraging water rate 0 sec0.10.60.9-0.80.9-0.9-0.70.70.80.4-0.50.80.7
Patch foraging water rate 12 sec0.93.54.3-1.51.9-1.9-2.12.12.11.5-1.72.01.9
Patch foraging water rate 18 sec0.92.12.6-1.11.6-1.6-1.51.51.51.2-1.41.51.5
Patch foraging water rate 24 sec1.72.43.4-1.81.8-1.8-1.11.11.21.4-1.61.51.7
Patch foraging water rate 6 sec1.82.73.3-1.51.6-1.6-1.81.81.81.4-1.31.71.6
Seeking ratio, delayed vs. immediate footshock0.40.61.10.4-0.70.71.1-1.1-1.0-0.80.5-0.8-0.6
Distance traveled before self-admin1.43.05.0-1.62.2-2.2-1.11.11.21.1-2.21.82.1
Distance traveled after self-admin0.30.51.3-0.70.7-0.7-0.50.50.51.2-0.60.60.6
Extensor digitorum longus weight0.31.31.4-1.21.2-1.2-1.11.11.11.0-1.21.11.2
Bone: elastic displacement1.41.82.4-1.61.2-1.2-1.41.41.41.2-1.21.31.2
Bone: elastic work2.83.74.6-2.11.9-1.9-1.91.92.01.6-1.82.02.1
Bone: endosteal estimation0.00.00.2-0.0-0.00.00.2-0.2-0.2-0.40.0-0.10.0
Bone: endosteal perimeter0.10.30.70.5-0.50.50.6-0.6-0.6-0.80.5-0.6-0.6
Epididymis fat weight0.10.71.7-0.71.2-1.2-0.40.40.50.1-1.30.81.1
Delta time in closed arm before/after self-admin0.40.31.20.11.0-1.0-0.10.10.1-0.1-1.10.30.3
Delta time in open arm before/after self-admin0.10.10.50.3-0.10.1-0.20.20.2-0.70.10.20.2
Diff in mean of infusions in LGA sessions0.20.30.6-0.40.7-0.7-0.40.40.5-0.1-0.70.70.8
Delay discount exponential model param2.12.93.81.4-1.91.91.7-1.7-1.7-1.11.9-1.7-1.7
Extinction: sum of active levers before priming0.30.40.7-0.70.8-0.8-0.60.60.60.1-0.70.70.8
Active lever presses in extinction session 61.01.01.9-0.81.3-1.3-0.80.80.80.2-1.41.11.2
Bone: final force0.71.11.4-1.11.0-1.0-1.11.11.10.9-0.81.11.2
Bone: final moment0.81.31.5-1.21.0-1.0-1.21.21.21.0-0.91.21.2
Food consumed during 24 hour testing period0.30.71.1-1.10.7-0.7-0.90.90.90.7-0.80.80.7
Glucose4.46.98.2-2.52.5-2.5-2.92.92.92.8-2.42.62.4
Heart weight1.93.14.8-1.52.2-2.2-1.31.31.41.3-2.11.82.0
Delay discount hyperbolic model param1.72.22.91.2-1.71.71.5-1.5-1.5-0.91.7-1.5-1.5
Intermittent access intake day 1-15 change0.42.13.8-1.11.1-1.1-2.02.01.91.6-1.11.41.0
Intermittent access intake escalation0.31.63.3-0.70.9-0.9-1.81.81.71.5-0.81.20.8
Intermittent access intake escalation 20.20.30.80.0-0.10.1-0.90.90.80.80.10.3-0.1
Intermitt. access day 1 inactive lever presses0.00.50.70.8-0.50.50.8-0.8-0.8-0.40.5-0.8-0.7
Intermitt. access day 15 inactive lever presses0.31.41.91.4-1.11.11.3-1.3-1.3-0.71.1-1.2-1.1
Intermitt. access escalation Index0.00.10.3-0.10.4-0.4-0.20.20.2-0.5-0.40.30.3
Intermittent access day 1 total infusions0.20.61.5-1.21.0-1.0-0.30.30.30.8-0.90.70.9
Intermittent access day 15 total infusions0.92.22.6-1.51.4-1.4-1.61.61.61.6-1.31.41.3
Intermittent access terminal intake (last 3 days)2.44.36.0-2.41.8-1.8-2.22.22.22.5-1.81.91.8
Intermittent access total infusions2.22.73.7-1.91.6-1.6-1.61.61.61.8-1.51.51.5
Intermittent access day 1 locomotion0.10.20.7-0.80.6-0.60.0-0.00.00.3-0.50.30.4
Intermittent access day 15 total locomotion1.03.74.8-2.22.1-2.1-1.61.61.71.9-2.01.92.0
Intermittent access total locomotion1.82.23.8-2.01.6-1.6-1.21.21.21.6-1.51.31.4
Intermittent access standard deviation0.20.81.70.6-1.21.20.4-0.4-0.50.31.3-1.0-1.3
Left kidney weight0.21.32.4-0.90.9-0.9-1.61.61.50.7-1.01.21.0
Right kidney weight0.32.23.2-1.71.3-1.3-1.81.81.71.2-1.21.41.2
Cocaine induced anxiety0.30.81.41.2-1.11.10.5-0.5-0.6-0.71.1-0.9-1.1
Post-drug Anxiety0.10.10.30.3-0.40.4-0.10.10.10.30.4-0.3-0.5
Baseline Anxiety0.30.51.1-0.80.8-0.8-0.60.60.61.0-0.80.70.7
Tail length2.815.320.9-4.63.7-3.7-3.83.83.84.0-3.93.83.9
Length with tail2.19.413.3-3.62.7-2.7-3.23.23.23.4-2.73.02.8
Length without tail0.52.54.0-1.71.1-1.1-1.91.91.92.0-0.91.51.2
Times rat made contact with spout0.10.10.2-0.4-0.30.3-0.10.1-0.00.00.3-0.2-0.4
Lifetime Intake1.21.42.8-1.71.1-1.1-1.11.11.11.5-1.11.11.0
Liver weight, left0.10.20.5-0.70.4-0.4-0.30.30.30.4-0.40.40.4
Liver weight, right0.50.81.2-1.10.8-0.8-1.01.01.00.9-0.70.80.8
Locomotor activity1.21.82.5-0.91.3-1.3-1.61.61.51.4-1.21.31.2
Locomotor testing distance0.30.71.0-0.30.7-0.7-1.01.00.91.0-0.70.80.8
Locomotor testing rearing0.10.31.01.0-0.60.60.2-0.2-0.2-0.50.5-0.4-0.4
Locomotion in novel chamber2.73.65.91.9-2.42.41.3-1.3-1.5-1.12.3-2.0-2.2
Locomotion in novel chamber post-restriction0.20.50.8-0.30.6-0.6-0.80.80.80.9-0.90.70.6
Fecal boli incidents, locomotor time 10.00.10.4-0.20.1-0.1-0.30.30.30.6-0.00.20.2
Change in fecal boli incidents, locomotor task0.00.00.0-0.0-0.10.10.1-0.1-0.10.10.1-0.1-0.1
Time >=10cm from walls, locomotor time 11.41.82.41.4-1.51.51.1-1.1-1.1-1.31.4-1.3-1.4
Bouts of movement, locomotor time 10.10.20.50.7-0.30.30.4-0.4-0.5-0.30.3-0.3-0.2
Total resting periods, locomotor time 10.20.30.50.7-0.40.40.6-0.6-0.6-0.50.4-0.4-0.2
Rest time, locomotor task time 10.40.60.80.5-0.90.90.8-0.8-0.8-0.60.9-0.8-0.8
Distance moved, locomotor task time 10.61.82.7-1.11.6-1.6-1.01.01.10.8-1.61.41.6
Vertical activity count, locomotor time 10.00.00.2-0.00.2-0.20.1-0.1-0.1-0.3-0.20.20.4
Time >=10cm from walls, locomotor time 20.00.10.30.4-0.40.40.3-0.3-0.3-0.60.3-0.4-0.4
Bouts of movement, locomotor time 20.10.20.30.4-0.50.50.4-0.4-0.5-0.30.3-0.5-0.6
Total resting periods, locomotor time 20.10.20.30.4-0.40.40.5-0.5-0.5-0.40.3-0.6-0.6
Rest time, locomotor task time 20.40.71.10.4-1.11.10.7-0.7-0.7-0.51.0-0.9-0.9
Distance moved, locomotor task time 20.91.22.3-0.71.5-1.5-0.60.60.70.4-1.41.11.3
Vertical activity count, locomotor time 20.51.22.81.3-0.40.41.4-1.4-1.3-1.70.6-0.9-0.6
Light reinforcement 10.93.94.7-2.02.1-2.1-1.71.71.72.1-2.21.92.0
Light reinforcement 22.04.55.4-2.32.3-2.3-1.81.81.92.3-2.22.02.0
Bone: marrow area0.00.00.2-0.00.0-0.00.2-0.2-0.2-0.40.0-0.00.1
Bone: maximum diameter0.00.00.1-0.40.1-0.1-0.20.20.2-0.10.00.20.3
Bone: maximum force0.50.91.4-1.20.8-0.8-1.01.01.00.9-0.71.01.1
Bone: maximum moment0.61.11.5-1.20.9-0.9-1.11.11.11.0-0.81.11.1
Mean time between licks in bursts0.00.20.30.5-0.30.30.5-0.5-0.5-0.40.3-0.4-0.3
Mean num. licks in bursts0.00.10.3-0.2-0.50.50.1-0.1-0.1-0.00.5-0.4-0.6
Cd content in liver1.51.61.8-1.21.2-1.2-1.31.31.31.3-1.31.31.3
Co content in liver0.20.20.30.3-0.40.40.5-0.5-0.5-0.40.5-0.4-0.4
Cu content in liver0.10.10.50.20.1-0.10.3-0.3-0.3-0.7-0.10.00.3
Fe content in liver0.81.01.7-1.21.1-1.1-0.70.70.80.5-1.11.11.3
K content in liver0.10.10.20.40.2-0.20.1-0.1-0.0-0.5-0.10.00.1
Mg content in liver0.10.10.40.5-0.20.20.3-0.3-0.3-0.60.2-0.2-0.2
Mn content in liver0.20.20.70.7-0.10.10.4-0.4-0.3-0.80.2-0.2-0.1
Na content in liver0.00.00.1-0.20.4-0.4-0.00.00.1-0.1-0.30.20.2
Rb content in liver2.02.42.7-1.41.6-1.6-1.51.51.51.3-1.61.61.7
Se content in liver0.00.00.10.20.2-0.20.2-0.2-0.1-0.1-0.20.00.2
Sr content in liver0.70.60.7-0.60.8-0.8-0.80.80.80.8-0.80.80.8
Zn content in liver0.20.20.40.00.6-0.6-0.40.40.40.2-0.60.50.6
Bone: minimum diameter0.00.00.0-0.10.1-0.1-0.00.00.0-0.10.00.10.1
Time in familiar zone, hab. session 13.33.64.11.6-2.02.01.9-1.9-1.9-1.82.0-1.9-1.9
Time in novel zone, hab. session 16.37.17.7-2.12.8-2.8-2.72.72.72.5-2.72.82.8
Total zone transitions, hab. session 10.71.01.4-1.01.2-1.2-0.90.90.80.9-1.11.01.0
Total locomotion distance, hab. session 10.20.20.40.2-0.50.50.6-0.6-0.6-0.30.5-0.5-0.4
Locomotion velocity, hab. session 10.20.20.40.1-0.40.40.6-0.6-0.6-0.30.4-0.5-0.4
Time in familiar zone, hab. session 21.21.42.20.9-1.51.51.1-1.1-1.1-0.91.3-1.1-1.1
Time in novel zone, hab. session 22.32.53.8-1.21.9-1.9-1.41.41.41.2-1.81.61.6
Total zone transitions, hab. session 20.00.00.10.1-0.20.20.3-0.3-0.30.10.2-0.2-0.1
Total locomotion distance, hab. session 21.82.33.01.2-1.71.71.5-1.5-1.6-1.11.7-1.6-1.5
Locomotion velocity, hab. session 22.53.33.81.5-2.02.01.9-1.9-1.9-1.51.9-1.9-1.8
Novel to familiar place preference ratio0.20.20.5-0.20.7-0.7-0.30.30.30.2-0.70.40.3
Novelty place preference0.30.40.8-0.30.9-0.9-0.50.50.40.4-0.90.50.5
Time in novel zone, NPP test0.40.50.9-0.40.9-0.9-0.60.60.50.5-1.00.60.5
Total zone transitions, NPP test0.00.00.1-0.30.0-0.0-0.10.10.00.40.00.10.1
Total locomotion distance, NPP test0.20.30.40.2-0.60.60.6-0.6-0.6-0.30.6-0.6-0.5
Locomotion velocity, NPP test0.30.40.60.2-0.60.60.8-0.8-0.8-0.50.6-0.7-0.6
Intraocular pressure0.00.00.00.0-0.10.1-0.10.10.10.00.1-0.0-0.1
Delta distance traveled before/after self-admin0.10.10.30.1-0.50.5-0.10.10.00.20.4-0.3-0.4
Delta ambulatory time before/after self-admin0.10.10.3-0.0-0.50.5-0.20.20.10.40.5-0.2-0.4
Parametrial fat weight3.89.09.5-3.03.0-3.0-2.92.92.93.0-3.13.03.1
Pavlov. Cond. lever latency1.31.61.9-1.31.3-1.3-1.21.21.31.4-1.21.31.2
Pavlov. Cond. magazine entry latency3.14.04.41.8-2.12.12.0-2.0-2.0-2.11.9-2.0-2.0
Pavlov. Cond. change in total contacts3.63.95.02.0-2.22.21.7-1.7-1.8-1.82.2-2.0-2.1
Pavlov. Cond. index score3.24.14.41.9-2.12.12.0-2.0-2.1-2.01.9-2.0-2.0
Pavlov. Cond. latency score2.32.93.11.6-1.71.71.7-1.7-1.7-1.81.6-1.7-1.7
Pavlov. Cond. lever contacts1.72.12.21.4-1.51.51.4-1.4-1.5-1.51.4-1.5-1.4
Pavlov. Cond. magazine entry number4.15.25.7-2.12.4-2.4-2.32.32.32.3-2.22.32.2
Pavlov. Cond. intertrial magazine entries0.10.10.20.2-0.20.20.3-0.3-0.30.10.2-0.4-0.5
Pavlov. Cond. lever-magazine prob. diff.4.35.36.02.3-2.42.42.2-2.2-2.3-2.22.3-2.3-2.3
Pavlov. Cond. response bias3.03.74.11.8-2.02.01.9-1.9-2.0-1.91.8-1.9-1.9
Pavlov. Cond. lever latency1.82.63.6-1.91.5-1.5-1.61.61.51.7-1.61.61.6
Pavlov. Cond. magazine entry latency2.43.43.81.7-1.91.91.8-1.8-1.8-1.71.9-1.9-2.0
Pavlov. Cond. change in total contacts0.82.02.41.5-1.41.41.5-1.5-1.5-1.31.4-1.4-1.4
Pavlov. Cond. index score2.23.53.92.0-1.91.91.9-1.9-1.9-1.81.8-1.9-1.9
Pavlov. Cond. latency score2.43.94.12.0-2.02.02.0-2.0-2.0-2.01.9-2.0-2.0
Pavlov. Cond. lever contacts1.52.23.11.8-1.41.41.4-1.4-1.4-1.51.5-1.5-1.5
Pavlov. Cond. magazine entry number5.16.66.9-2.52.6-2.6-2.62.62.62.5-2.52.62.6
Pavlov. Cond. intertrial magazine entries0.20.40.80.9-0.60.60.6-0.6-0.6-0.60.7-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.2.23.43.92.0-1.81.81.8-1.8-1.8-1.81.8-1.9-1.9
Pavlov. Cond. response bias2.73.84.62.2-1.91.91.9-1.9-1.9-1.91.9-1.9-2.0
Time in closed arm before self-admin0.20.40.90.5-0.90.90.4-0.4-0.5-0.20.9-0.6-0.7
Time in closed arm after self-admin0.40.40.80.9-0.50.50.6-0.6-0.6-0.70.4-0.7-0.8
Time in open arm before self-admin0.10.10.3-0.10.3-0.3-0.30.30.30.5-0.20.20.2
Time in open arm after self-admin0.10.20.80.80.0-0.0-0.10.10.1-0.90.10.10.1
Bone: periosteal estimation0.10.30.5-0.70.6-0.6-0.50.50.50.3-0.50.60.7
Bone: periosteal perimeter0.10.10.30.2-0.30.30.4-0.4-0.4-0.60.4-0.3-0.2
Bone: post-yield work0.00.00.1-0.1-0.00.0-0.20.20.20.30.10.10.1
Progressive ratio test 1 active lever presses1.93.34.2-2.11.7-1.7-1.91.91.92.0-1.71.81.6
Progressive ratio test 1 breakpoint2.03.44.2-2.01.8-1.8-1.91.91.91.9-1.71.81.7
Progressive ratio test 1 inactive lever presses0.00.00.1-0.10.3-0.3-0.00.0-0.00.3-0.20.0-0.0
Progressive ratio test 2 active lever presses1.21.83.0-1.61.1-1.1-1.41.41.41.7-1.11.21.0
Progressive ratio test 2 breakpoint1.41.83.2-1.61.2-1.2-1.51.51.41.8-1.11.21.0
Progressive ratio test 2 inactive lever presses0.10.20.8-0.80.3-0.3-0.40.40.40.9-0.20.20.0
Incentive Sensitization - Responses0.41.12.8-1.50.6-0.6-1.11.11.11.7-0.60.80.6
Incentive Sensitization - Breakpoint0.40.92.6-1.40.6-0.6-1.01.01.01.6-0.50.70.5
Sum of active levers in priming session hrs 5-60.80.81.7-1.30.9-0.9-0.60.60.70.6-0.90.91.1
Progressive ratio0.61.92.60.8-1.41.41.6-1.6-1.6-0.91.3-1.5-1.5
Food seeking constrained by brief footshock1.01.22.3-1.51.1-1.1-0.90.90.91.3-1.01.11.1
Seeking ratio, punishment vs. effort1.83.94.5-1.81.9-1.9-2.12.12.11.8-1.82.12.1
Retroperitoneal fat weight1.98.59.7-3.12.9-2.9-2.92.92.83.1-3.02.82.8
Reaction time number correct0.10.40.6-0.70.6-0.6-0.70.70.70.5-0.20.70.7
Reaction time mean minus median0.00.10.60.80.2-0.2-0.10.10.1-0.5-0.20.20.3
Reaction time mean minus median AUC0.10.40.60.30.6-0.6-0.70.70.70.1-0.70.70.8
Reaction time num false alarms0.30.50.70.8-0.50.50.8-0.8-0.7-0.70.6-0.6-0.5
Reaction time num false alarms AUC0.10.20.30.5-0.40.40.5-0.5-0.5-0.40.4-0.4-0.4
Reaction time trials correct on left0.10.40.6-0.70.6-0.6-0.70.70.70.5-0.20.70.7
Reaction time trials on left0.10.40.6-0.70.6-0.6-0.70.70.80.5-0.20.70.7
Reaction time mean0.30.82.21.5-0.50.50.9-0.9-0.9-1.30.3-0.7-0.5
Reaction time mean AUC0.30.82.21.5-0.40.41.0-1.0-1.0-1.40.3-0.7-0.4
Median of all reaction times0.81.32.71.6-0.80.81.3-1.3-1.3-1.50.6-1.0-0.8
Reaction time omissions0.10.20.90.9-0.10.10.4-0.4-0.4-0.4-0.0-0.2-0.1
Reaction time false alarm rate0.20.30.50.7-0.50.50.6-0.6-0.6-0.50.4-0.5-0.5
Reaction time premature initiation rate2.84.47.9-1.81.9-1.9-2.32.32.22.8-1.82.01.8
Reaction time premature initiations1.44.26.9-1.91.8-1.8-2.32.32.22.6-1.52.01.8
Std. dev. reaction times0.10.41.61.3-0.20.20.5-0.5-0.5-1.10.1-0.3-0.1
Reaction time trials completed0.10.40.6-0.70.6-0.6-0.70.70.80.5-0.20.70.7
Reaction time trials AUC0.20.50.7-0.80.7-0.7-0.80.80.80.6-0.30.80.8
Run reversals in cocaine runway, females2.12.33.21.5-1.81.81.3-1.3-1.4-1.41.8-1.5-1.5
Run reversals in cocaine runway, males1.21.31.9-1.30.9-0.9-1.41.41.21.2-1.01.10.9
Latency to leave start box in cocaine runway6.69.111.63.4-2.62.63.4-3.4-3.3-3.22.6-2.9-2.7
Latency to leave start box in cocaine runway, F3.84.76.82.5-1.61.62.6-2.6-2.4-2.61.7-2.0-1.7
Latency to leave start box in cocaine runway, M4.64.45.02.2-2.12.12.1-2.1-2.1-1.62.1-2.2-2.2
Std. dev. time between licks in bursts1.83.54.02.0-1.81.81.9-1.9-1.9-1.81.9-1.9-1.8
Total sessions with >9 infusions0.20.20.7-0.80.5-0.5-0.30.30.30.6-0.40.40.4
Short access day 1 total inactive lever presses0.30.60.80.4-0.70.70.9-0.9-0.9-0.80.8-0.9-0.8
Short access day 10 total inactive lever presses0.31.82.31.3-1.21.21.5-1.5-1.5-1.31.2-1.4-1.4
Short access day 1 total infusions0.10.20.2-0.3-0.40.40.5-0.5-0.5-0.40.4-0.4-0.4
Short access day 10 total infusions2.54.26.9-2.62.1-2.1-1.81.81.82.1-2.11.92.0
Short access total infusions0.30.41.4-1.20.6-0.6-0.50.50.50.6-0.50.50.5
Short access day 1 locomotion0.30.51.2-1.10.9-0.9-0.40.40.40.3-0.90.70.8
Short access day 10 total locomotion0.00.10.7-0.80.2-0.20.2-0.2-0.20.6-0.2-0.10.0
Short access total locomotion0.30.51.3-1.10.8-0.8-0.30.30.40.8-0.80.60.7
One hour access (0.3 mA shock)1.21.42.7-1.41.0-1.0-1.31.31.31.6-0.91.00.9
Compulsive drug intake2.33.44.01.5-1.91.91.9-1.9-1.9-1.41.8-2.0-2.0
One hour access (shock baseline)2.77.18.5-2.92.7-2.7-2.62.62.72.7-2.52.62.6
Social response proportion0.30.30.70.7-0.60.60.2-0.2-0.3-0.60.8-0.5-0.7
Social responses0.10.10.2-0.30.3-0.3-0.40.40.40.4-0.20.30.3
Social time3.04.66.62.6-2.12.12.1-2.1-2.1-2.22.0-2.1-2.2
Soleus weight8.524.927.3-5.24.9-4.9-5.15.15.14.8-4.95.05.0
Bone: stiffness0.20.30.90.4-0.80.80.4-0.4-0.4-0.40.9-0.5-0.6
Tibialis anterior weight0.00.10.2-0.30.4-0.4-0.20.20.20.1-0.40.30.4
Time to tail flick, vehicle, before self-admin0.10.10.4-0.60.1-0.1-0.40.40.40.50.10.20.1
Time to tail flick, vehicle, after self-admin1.02.02.21.2-1.31.31.5-1.5-1.5-1.31.5-1.4-1.4
Time to tail flick, test, before self-admin0.20.30.3-0.50.5-0.5-0.50.50.50.3-0.50.60.6
Time to tail flick, test, after self-admin0.30.31.0-0.40.7-0.7-0.10.10.20.3-1.00.50.7
Delta time to tail flick, vehicle, before/after SA1.21.32.61.2-0.70.71.4-1.4-1.3-1.60.7-1.0-0.8
Delta time to tail flick, test, before/after SA0.10.20.70.10.6-0.60.1-0.1-0.0-0.3-0.80.20.4
Tibia length0.00.10.3-0.60.0-0.0-0.30.30.30.2-0.00.10.0
Ambulatory time before self-admin1.03.15.5-1.42.3-2.3-1.11.11.31.1-2.31.82.1
Ambulatory time after self-admin1.01.62.3-1.21.5-1.5-0.90.90.91.4-1.51.21.3
Bone: tissue strength6.56.87.6-2.62.5-2.5-2.72.72.72.8-2.42.62.6
Total heroin consumption0.91.01.6-1.21.2-1.2-0.50.50.61.0-1.20.91.1
Bone: trabecular number0.10.10.30.2-0.50.50.2-0.2-0.2-0.10.6-0.4-0.5
Bone: trabecular spacing0.00.00.10.10.2-0.20.0-0.00.00.2-0.30.10.1
Bone: trabecular thickness1.01.42.0-1.41.0-1.0-1.31.31.31.2-0.81.21.2
Bone: trabecular tissue density0.10.20.2-0.40.3-0.3-0.50.50.40.5-0.40.50.5
Water consumed over 24 hours0.30.60.90.3-0.90.90.6-0.6-0.7-0.60.9-0.8-0.9
Number of responses in last shaping day0.20.30.40.4-0.50.50.5-0.5-0.5-0.50.5-0.6-0.6