Hub : Genes

Slco1a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Slco1a1 0.89 0.03 4.2e-06 0.01 0.01 0 0 4.0e-02 2.2e-02 3.6e-01 2.0e-01
2 RMTg alternative polyA XM_063286619.1 0.1 0.09 7.8e-03 0.07 0.07 0.08 0.07 6.1e-03 6.2e-03 3.8e-03 5.4e-03
3 Liver isoform ratio NM_017111.2 0.34 0.22 0.0e+00 0.19 0.2 0.2 0.2 1.3e-20 1.4e-21 6.6e-22 1.5e-21
4 Liver alternative TSS XM_063286619.1 0.51 0.32 0.0e+00 0.23 0.24 0.23 0.23 9.5e-25 7.1e-26 1.3e-25 1.2e-25
5 Liver alternative TSS NM_017111.2 0.41 0.27 0.0e+00 0.21 0.22 0.22 0.22 2.3e-23 2.1e-24 3.4e-24 3.4e-24
6 Liver alternative polyA XM_063286619.1 0.19 0.14 0.0e+00 0.11 0.12 0.11 0.11 1.5e-12 7.4e-13 2.8e-12 2.6e-12
7 Liver gene expression Slco1a1 0.63 0.18 0.0e+00 0.42 0.44 0.44 0.43 4.9e-51 8.8e-53 8.7e-53 1.7e-52
8 Liver isoform ratio XM_063286619.1 0.82 0.22 9.0e-13 0.08 0.08 0.08 0.08 6.9e-09 3.1e-09 6.6e-09 6.8e-09
9 Liver alternative polyA NM_017111.2 0.28 0.18 0.0e+00 0.16 0.18 0.16 0.16 3.6e-17 3.1e-19 1.3e-17 6.3e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.10.1-0.30.3-0.20.4-0.4-0.30.2-0.30.4
Area under the delay curve1.01.51.70.81.3-1.21.3-1.3-1.31.2-1.31.3
BMI with tail1.65.712.4-3.5-2.42.3-2.02.02.2-2.22.3-2.2
BMI without tail0.00.21.7-1.3-0.1-0.10.2-0.2-0.10.2-0.10.1
Body weight0.83.612.9-3.6-1.81.6-1.41.41.5-1.61.7-1.6
Weight adjusted by age0.10.32.4-1.6-0.20.20.2-0.1-0.1-0.0-0.00.1
Bone surface0.10.20.3-0.20.4-0.10.5-0.5-0.50.2-0.50.5
Bone volume0.10.20.7-0.80.3-0.10.5-0.5-0.40.2-0.40.5
Breakpoint value in progressive ratio session1.12.02.5-1.61.4-1.41.5-1.4-1.41.5-1.31.3
Number of licking bursts0.00.10.8-0.9-0.1-0.00.1-0.1-0.00.00.00.0
Context. condit. distance diff. score0.50.61.81.3-0.50.6-0.80.80.7-0.70.7-0.8
Locomotion velocity, session 10.80.91.30.3-0.80.9-1.11.11.1-1.01.1-1.1
Locomotion distance, session 10.20.31.01.0-0.20.3-0.50.50.4-0.40.4-0.4
Locomotion velocity, session 20.00.00.20.40.00.1-0.20.20.1-0.10.1-0.1
Locomotion distance, session 20.71.02.31.51.1-1.00.8-0.8-0.90.9-0.90.9
Locomotion velocity, session 32.83.33.8-0.4-1.81.9-2.02.01.9-1.91.9-1.9
Locomotion distance, session 30.40.51.21.1-0.50.6-0.70.70.6-0.70.6-0.6
Stereotopy head waving bouts, day 30.40.40.6-0.8-0.60.6-0.70.70.7-0.50.7-0.7
Stereotopy head waving duration, day 30.30.42.4-1.5-0.40.3-0.30.30.4-0.30.5-0.4
Locomotion velocity, session 70.20.20.5-0.7-0.40.4-0.50.50.5-0.40.5-0.5
Locomotion distance, session 70.00.00.2-0.40.1-0.10.1-0.1-0.10.1-0.10.1
Stereotopy head waving bouts, day 70.40.40.60.60.8-0.70.6-0.6-0.70.7-0.70.7
Stereotopy head waving duration, day 70.10.20.2-0.00.5-0.50.4-0.4-0.40.4-0.40.4
Locomotion velocity, session 80.60.75.92.40.20.1-0.40.40.3-0.20.2-0.3
Locomotion distance, session 80.50.76.12.50.20.0-0.40.30.2-0.20.1-0.2
Degree of sensitization distance0.30.31.9-1.40.2-0.30.4-0.4-0.40.4-0.30.3
Degree of sensitization stereotypy0.91.01.20.71.1-1.01.0-1.0-1.01.0-1.01.0
Conditioned locomotion0.10.10.1-0.0-0.40.3-0.30.30.3-0.30.3-0.3
Cocaine response after cond. corrected0.60.93.61.90.9-0.90.6-0.6-0.70.8-0.80.7
Cocaine response after cond. not corrected0.20.32.01.40.5-0.50.3-0.3-0.30.4-0.40.3
Cocaine response before conditioning1.51.82.7-1.6-1.41.4-1.21.21.2-1.41.3-1.2
Saline control response3.14.35.6-2.4-2.22.2-1.91.92.0-2.02.1-2.0
Bone: connectivity density0.30.50.70.40.8-0.70.8-0.8-0.80.6-0.80.8
Bone: cortical apparent density0.20.40.6-0.7-0.60.7-0.50.50.6-0.50.6-0.6
Bone: cortical area0.50.92.5-1.6-1.00.9-0.70.70.7-0.90.8-0.7
Bone: cortical porosity0.00.00.10.3-0.0-0.1-0.10.10.1-0.00.1-0.1
Bone: cortical porosity0.20.20.30.0-0.40.3-0.50.50.5-0.50.5-0.5
Bone: cortical thickness1.11.84.4-2.1-1.41.3-1.11.11.2-1.31.2-1.1
Bone: cortical thickness1.61.94.9-2.2-1.41.3-1.11.11.2-1.41.3-1.2
Bone: cortical tissue density0.20.40.5-0.7-0.60.7-0.50.60.6-0.60.6-0.6
Condit. Reinf. active minus inactive responses0.30.43.01.7-0.00.2-0.40.30.3-0.30.2-0.2
Condit. Reinf. active-inactive response ratio0.91.06.12.50.9-0.70.4-0.5-0.60.5-0.70.6
Condit. Reinf. active responses0.30.40.50.7-0.50.7-0.70.70.7-0.70.6-0.6
Condit. Reinf. inactive responses0.50.61.9-1.4-0.80.7-0.60.60.6-0.60.7-0.6
Incentive salience index mean0.20.21.71.30.10.1-0.20.10.1-0.10.0-0.1
Condit. Reinf. lever presses0.30.50.60.20.8-0.70.8-0.8-0.70.7-0.70.8
Condit. Reinf. active minus inactive responses1.01.51.80.7-1.21.3-1.31.31.3-1.31.2-1.3
Condit. Reinf. active-inactive response ratio0.20.31.51.20.5-0.50.4-0.4-0.40.4-0.50.4
Condit. Reinf. active responses2.94.25.10.6-2.12.2-2.22.22.2-2.22.1-2.2
Condit. Reinf. inactive responses4.05.96.7-0.8-2.62.6-2.52.52.5-2.62.5-2.5
Condit. Reinf. lever presses2.23.24.2-1.3-2.11.9-1.81.81.8-1.81.8-1.8
Condit. Reinf. lever reinforcers received3.14.35.20.7-2.12.2-2.32.32.2-2.22.1-2.2
Conditioned reinforcement - actives0.41.41.80.2-1.31.2-1.31.31.3-1.11.3-1.3
Conditioned reinforcement - inactives0.41.11.41.2-0.90.9-1.11.11.0-1.01.0-1.0
Conditioned locomotion2.03.03.60.3-1.81.9-1.91.91.8-1.71.8-1.8
Patch foraging indifference point 0 sec0.30.91.3-0.2-0.91.1-1.01.01.0-1.00.9-0.9
Patch foraging indifference point AUC0.40.91.1-0.1-0.91.0-1.01.01.0-1.01.0-1.0
Delay disc. indifference point, 0s delay0.50.50.60.40.7-0.80.8-0.8-0.80.7-0.80.8
Delay disc. indifference point, 16s delay0.50.71.00.71.0-0.70.8-0.8-0.80.8-0.80.8
Delay disc. indifference point, 2s delay0.00.00.10.3-0.2-0.0-0.10.10.10.10.1-0.1
Delay disc. indifference point, 24s delay2.23.54.71.82.2-1.91.8-1.8-1.91.8-1.91.9
Delay disc. indifference point, 4s delay0.20.20.5-0.70.3-0.40.4-0.4-0.40.3-0.30.3
Delay disc. indifference point, 8s delay1.01.62.00.61.2-1.31.4-1.4-1.41.3-1.41.4
Indifference point function ln k0.72.02.40.91.5-1.51.5-1.5-1.51.4-1.51.5
Indifference point function log k0.72.02.40.91.5-1.51.5-1.5-1.51.4-1.51.5
Patch foraging total patch changes 0 sec0.10.30.5-0.1-0.50.7-0.60.60.6-0.60.5-0.5
Patch foraging total patch changes 12 sec1.52.02.4-0.7-1.41.5-1.51.51.5-1.51.5-1.5
Patch foraging total patch changes 18 sec0.20.62.5-1.6-0.80.6-0.40.40.5-0.50.6-0.5
Patch foraging total patch changes 24 sec0.41.24.2-2.1-1.21.1-0.80.80.9-0.71.0-0.9
Patch foraging total patch changes 6 sec1.83.14.1-0.6-1.72.0-1.81.81.8-1.91.8-1.8
Patch foraging time to switch 0 sec0.10.20.30.6-0.50.3-0.50.50.4-0.40.4-0.4
Patch foraging water rate 0 sec0.00.10.7-0.80.3-0.10.3-0.3-0.20.1-0.20.2
Patch foraging water rate 12 sec0.10.31.8-1.3-0.30.6-0.30.30.3-0.50.4-0.3
Patch foraging water rate 18 sec0.20.53.6-1.9-0.20.5-0.20.20.3-0.50.3-0.3
Patch foraging water rate 24 sec0.30.41.31.10.9-0.50.4-0.5-0.50.4-0.60.5
Patch foraging water rate 6 sec0.00.00.1-0.30.20.00.0-0.0-0.0-0.0-0.00.1
Seeking ratio, delayed vs. immediate footshock0.91.41.6-0.2-1.21.1-1.31.31.2-1.31.2-1.3
Distance traveled before self-admin0.40.81.0-0.3-0.90.8-1.01.01.0-1.01.0-1.0
Distance traveled after self-admin0.40.76.0-2.4-0.40.3-0.20.20.3-0.30.4-0.3
Extensor digitorum longus weight0.51.92.4-1.4-1.51.5-1.31.31.3-1.41.4-1.3
Bone: elastic displacement0.00.00.0-0.20.2-0.00.2-0.2-0.20.1-0.20.2
Bone: elastic work0.00.10.2-0.4-0.20.3-0.20.20.2-0.30.2-0.1
Bone: endosteal estimation0.10.10.20.20.4-0.30.4-0.4-0.40.3-0.40.4
Bone: endosteal perimeter0.20.61.81.30.8-0.60.6-0.6-0.70.7-0.70.7
Epididymis fat weight0.10.73.9-2.0-0.50.5-0.40.40.5-0.50.6-0.5
Delta time in closed arm before/after self-admin0.40.40.4-0.10.6-0.50.7-0.7-0.60.7-0.60.7
Delta time in open arm before/after self-admin0.80.91.4-1.20.8-0.91.0-1.0-0.91.1-0.90.9
Diff in mean of infusions in LGA sessions2.74.86.1-1.62.1-2.22.4-2.3-2.32.5-2.12.3
Delay discount exponential model param1.41.92.2-0.8-1.51.4-1.41.41.5-1.41.5-1.5
Extinction: sum of active levers before priming0.60.92.6-1.60.7-0.81.0-0.9-0.90.8-0.80.8
Active lever presses in extinction session 61.71.72.20.21.5-1.41.4-1.4-1.41.3-1.31.4
Bone: final force0.91.42.2-1.5-1.21.3-1.11.11.1-1.21.1-1.1
Bone: final moment0.71.12.2-1.5-1.01.1-0.90.90.9-1.10.9-0.9
Food consumed during 24 hour testing period0.30.70.9-0.9-0.80.9-0.70.70.8-0.90.8-0.8
Glucose0.81.31.6-0.6-1.31.2-1.21.21.2-1.21.2-1.2
Heart weight1.11.72.30.6-1.21.3-1.41.41.4-1.51.3-1.4
Delay discount hyperbolic model param0.91.11.3-0.6-1.11.1-1.11.11.1-1.11.1-1.1
Intermittent access intake day 1-15 change0.10.60.9-0.6-0.71.0-0.80.80.8-1.00.8-0.7
Intermittent access intake escalation0.21.01.4-0.3-0.91.2-1.11.11.0-1.21.0-1.0
Intermittent access intake escalation 20.91.52.2-0.5-1.11.4-1.31.31.3-1.51.2-1.2
Intermitt. access day 1 inactive lever presses0.00.20.3-0.30.3-0.40.5-0.5-0.50.4-0.50.5
Intermitt. access day 15 inactive lever presses0.21.15.92.4-0.30.6-0.80.80.7-0.90.5-0.6
Intermitt. access escalation Index0.20.61.00.61.0-0.80.8-0.8-0.80.6-0.80.8
Intermittent access day 1 total infusions0.51.412.33.50.5-0.2-0.20.1-0.00.1-0.20.0
Intermittent access day 15 total infusions0.40.95.32.3-0.30.5-0.80.80.7-0.50.6-0.7
Intermittent access terminal intake (last 3 days)0.91.66.62.6-0.60.9-1.21.21.0-1.00.9-1.0
Intermittent access total infusions0.91.11.71.3-0.81.0-1.11.11.0-1.01.0-1.0
Intermittent access day 1 locomotion0.91.715.13.90.4-0.3-0.20.1-0.10.2-0.20.1
Intermittent access day 15 total locomotion0.20.80.90.2-1.00.9-1.00.90.9-0.80.9-0.9
Intermittent access total locomotion0.70.81.11.1-0.80.9-1.01.00.9-0.80.9-0.9
Intermittent access standard deviation1.15.816.44.0-1.42.2-2.42.32.1-2.31.9-2.0
Left kidney weight0.10.51.21.1-0.50.5-0.70.70.7-0.60.6-0.7
Right kidney weight0.10.40.60.00.4-0.60.7-0.7-0.70.8-0.60.7
Cocaine induced anxiety0.61.72.61.01.6-1.41.2-1.2-1.31.2-1.31.3
Post-drug Anxiety2.02.32.9-0.91.4-1.51.7-1.7-1.61.5-1.61.6
Baseline Anxiety0.20.41.5-1.2-0.90.6-0.30.30.4-0.40.4-0.4
Tail length0.63.03.50.71.8-1.81.8-1.8-1.81.8-1.91.9
Length with tail0.10.40.5-0.50.7-0.60.7-0.7-0.60.6-0.60.6
Length without tail1.05.16.9-2.6-2.22.3-2.12.12.2-2.42.3-2.2
Times rat made contact with spout0.50.60.8-0.00.9-0.70.9-0.9-0.80.5-0.80.8
Lifetime Intake0.70.93.82.0-0.50.6-0.90.80.8-0.60.7-0.7
Liver weight, left0.91.62.41.5-1.01.1-1.41.31.3-1.21.2-1.3
Liver weight, right0.40.60.9-0.7-0.90.8-0.70.80.8-0.80.8-0.8
Locomotor activity0.20.43.1-1.80.1-0.10.4-0.3-0.30.1-0.20.2
Locomotor testing distance1.02.46.6-2.6-1.41.6-1.21.21.3-1.61.4-1.3
Locomotor testing rearing1.45.06.5-2.4-2.12.5-2.12.12.1-2.42.2-2.1
Locomotion in novel chamber1.01.41.8-0.1-1.11.3-1.31.31.2-1.31.2-1.2
Locomotion in novel chamber post-restriction0.31.03.31.81.2-0.90.7-0.8-0.80.6-0.90.8
Fecal boli incidents, locomotor time 10.20.40.9-0.90.3-0.80.6-0.6-0.60.7-0.50.6
Change in fecal boli incidents, locomotor task0.70.70.90.6-0.80.9-0.90.90.9-0.70.9-0.9
Time >=10cm from walls, locomotor time 13.03.79.4-3.1-2.01.8-1.51.51.6-1.81.8-1.7
Bouts of movement, locomotor time 10.10.10.7-0.90.0-0.20.2-0.2-0.20.1-0.10.1
Total resting periods, locomotor time 10.10.10.7-0.9-0.1-0.00.1-0.1-0.10.0-0.00.0
Rest time, locomotor task time 10.10.20.5-0.70.3-0.30.5-0.4-0.40.3-0.40.4
Distance moved, locomotor task time 10.10.40.50.4-0.50.6-0.70.70.7-0.60.6-0.6
Vertical activity count, locomotor time 10.21.72.10.3-1.41.4-1.41.41.4-1.21.3-1.4
Time >=10cm from walls, locomotor time 20.20.50.6-0.4-0.70.7-0.70.70.7-0.80.7-0.7
Bouts of movement, locomotor time 21.65.46.21.22.4-2.42.5-2.5-2.52.5-2.52.5
Total resting periods, locomotor time 21.35.15.81.22.3-2.32.4-2.4-2.42.3-2.42.4
Rest time, locomotor task time 21.52.63.00.71.6-1.71.7-1.7-1.71.7-1.71.7
Distance moved, locomotor task time 20.50.70.8-0.6-0.80.9-0.80.80.8-0.80.8-0.8
Vertical activity count, locomotor time 20.30.70.9-0.3-0.90.8-0.90.90.9-0.80.9-0.9
Light reinforcement 10.10.62.11.50.8-0.70.6-0.6-0.60.6-0.70.6
Light reinforcement 22.14.85.41.92.3-2.32.1-2.1-2.22.3-2.22.2
Bone: marrow area0.00.10.10.10.4-0.20.4-0.4-0.40.2-0.40.4
Bone: maximum diameter0.30.60.7-0.7-0.80.9-0.70.70.8-0.80.8-0.8
Bone: maximum force0.10.20.4-0.6-0.40.5-0.30.30.4-0.50.4-0.3
Bone: maximum moment0.00.10.3-0.6-0.20.4-0.10.10.2-0.30.1-0.1
Mean time between licks in bursts0.10.51.81.3-0.60.2-0.80.70.7-0.20.6-0.7
Mean num. licks in bursts0.10.41.01.00.8-0.40.5-0.5-0.50.3-0.60.5
Cd content in liver0.40.51.01.00.8-0.60.6-0.6-0.60.6-0.70.6
Co content in liver1.01.11.4-0.21.1-1.01.2-1.2-1.21.1-1.11.2
Cu content in liver4.95.86.8-2.4-2.62.6-2.22.32.3-2.52.4-2.3
Fe content in liver2.22.83.1-1.0-1.71.7-1.71.71.7-1.71.8-1.7
K content in liver0.70.73.5-1.90.4-0.40.8-0.7-0.60.6-0.60.6
Mg content in liver1.11.23.0-1.70.7-0.91.2-1.1-1.01.1-1.01.0
Mn content in liver1.01.24.9-2.2-1.20.8-0.70.70.8-0.70.9-0.8
Na content in liver2.73.03.4-1.7-1.81.8-1.71.71.7-1.71.8-1.7
Rb content in liver2.83.23.9-1.5-2.02.0-1.71.71.8-1.91.8-1.7
Se content in liver0.10.10.6-0.8-0.1-0.10.2-0.1-0.10.2-0.10.1
Sr content in liver0.50.40.60.10.8-0.70.7-0.7-0.70.5-0.70.7
Zn content in liver0.30.42.2-1.5-0.60.5-0.30.30.3-0.40.4-0.3
Bone: minimum diameter0.81.62.00.11.4-1.31.4-1.4-1.41.2-1.41.4
Time in familiar zone, hab. session 10.10.10.40.60.2-0.20.2-0.2-0.20.1-0.20.2
Time in novel zone, hab. session 10.30.30.4-0.00.6-0.60.5-0.5-0.50.6-0.50.5
Total zone transitions, hab. session 10.30.50.80.90.9-0.70.6-0.6-0.60.6-0.70.6
Total locomotion distance, hab. session 10.00.00.0-0.2-0.00.1-0.10.10.1-0.10.1-0.1
Locomotion velocity, hab. session 10.00.00.1-0.4-0.00.1-0.00.00.0-0.00.1-0.1
Time in familiar zone, hab. session 21.92.12.51.61.5-1.51.4-1.4-1.41.4-1.51.4
Time in novel zone, hab. session 21.11.21.3-1.0-1.01.1-1.11.11.1-1.11.1-1.1
Total zone transitions, hab. session 20.20.20.40.20.6-0.40.5-0.5-0.50.3-0.50.5
Total locomotion distance, hab. session 20.20.30.5-0.70.5-0.40.5-0.5-0.50.3-0.40.5
Locomotion velocity, hab. session 20.10.20.9-0.90.3-0.20.4-0.3-0.30.2-0.30.3
Novel to familiar place preference ratio1.11.52.41.51.4-1.21.0-1.0-1.11.2-1.21.1
Novelty place preference1.01.32.51.61.3-1.20.9-1.0-1.01.1-1.11.0
Time in novel zone, NPP test0.91.02.91.71.1-1.00.7-0.8-0.80.9-0.90.9
Total zone transitions, NPP test0.20.41.01.0-0.20.5-0.60.60.5-0.50.5-0.5
Total locomotion distance, NPP test0.10.10.3-0.5-0.20.3-0.20.20.2-0.20.3-0.3
Locomotion velocity, NPP test0.00.10.5-0.7-0.10.1-0.10.10.1-0.10.1-0.1
Intraocular pressure1.93.13.70.31.9-1.81.9-1.9-1.91.8-1.91.9
Delta distance traveled before/after self-admin0.40.41.2-1.10.4-0.50.6-0.6-0.60.7-0.50.6
Delta ambulatory time before/after self-admin0.71.31.5-0.11.1-1.21.2-1.2-1.21.2-1.21.2
Parametrial fat weight1.94.65.61.32.4-2.42.1-2.1-2.22.2-2.22.2
Pavlov. Cond. lever latency0.20.30.3-0.3-0.50.5-0.60.60.6-0.50.6-0.6
Pavlov. Cond. magazine entry latency2.33.03.51.51.9-1.71.7-1.7-1.71.7-1.81.8
Pavlov. Cond. change in total contacts0.20.20.91.00.5-0.20.2-0.2-0.20.2-0.30.3
Pavlov. Cond. index score1.21.61.81.31.4-1.21.2-1.2-1.21.2-1.31.3
Pavlov. Cond. latency score1.11.41.60.91.3-1.21.2-1.2-1.21.2-1.31.2
Pavlov. Cond. lever contacts0.50.60.70.10.7-0.70.8-0.8-0.80.7-0.80.8
Pavlov. Cond. magazine entry number1.92.42.9-1.4-1.71.5-1.51.51.5-1.51.6-1.5
Pavlov. Cond. intertrial magazine entries3.64.45.1-0.1-2.12.2-2.32.32.2-2.22.2-2.2
Pavlov. Cond. lever-magazine prob. diff.1.01.22.31.51.2-1.00.9-1.0-1.01.0-1.11.0
Pavlov. Cond. response bias1.72.12.51.51.6-1.41.4-1.4-1.41.4-1.51.5
Pavlov. Cond. lever latency2.12.94.00.72.0-1.81.8-1.8-1.81.7-1.81.8
Pavlov. Cond. magazine entry latency0.10.10.8-0.9-0.1-0.10.2-0.1-0.10.1-0.10.1
Pavlov. Cond. change in total contacts1.74.15.6-1.2-2.42.1-2.12.12.1-2.02.1-2.1
Pavlov. Cond. index score0.60.91.5-1.0-1.21.0-0.90.90.9-0.90.9-0.9
Pavlov. Cond. latency score0.61.01.6-1.1-1.31.0-0.90.91.0-1.01.0-0.9
Pavlov. Cond. lever contacts1.92.84.0-0.8-2.01.8-1.71.71.7-1.71.7-1.7
Pavlov. Cond. magazine entry number0.10.10.10.2-0.20.3-0.30.30.3-0.20.3-0.3
Pavlov. Cond. intertrial magazine entries1.02.23.0-0.8-1.31.6-1.51.51.5-1.71.6-1.6
Pavlov. Cond. lever-magazine prob. diff.0.40.61.0-0.8-1.00.8-0.70.70.7-0.70.8-0.7
Pavlov. Cond. response bias0.91.31.9-0.5-1.41.2-1.21.21.2-1.11.2-1.2
Time in closed arm before self-admin1.01.88.32.91.3-0.90.9-0.9-1.00.8-1.11.0
Time in closed arm after self-admin0.60.73.92.00.8-0.50.5-0.5-0.60.5-0.60.6
Time in open arm before self-admin0.10.21.4-1.2-0.3-0.00.0-0.00.0-0.00.1-0.0
Time in open arm after self-admin0.60.73.4-1.80.3-0.70.7-0.7-0.60.7-0.50.6
Bone: periosteal estimation0.00.10.6-0.8-0.10.20.0-0.00.0-0.20.00.0
Bone: periosteal perimeter0.30.52.61.60.6-0.50.4-0.4-0.50.4-0.50.5
Bone: post-yield work0.30.50.6-0.60.7-0.50.8-0.8-0.70.6-0.70.8
Progressive ratio test 1 active lever presses1.73.020.14.5-0.50.7-1.21.21.0-0.80.8-1.0
Progressive ratio test 1 breakpoint1.83.021.04.6-0.40.7-1.21.10.9-0.80.7-0.9
Progressive ratio test 1 inactive lever presses1.74.338.46.20.4-0.2-0.40.40.10.1-0.2-0.1
Progressive ratio test 2 active lever presses0.30.53.81.90.0-0.0-0.40.40.3-0.00.2-0.3
Progressive ratio test 2 breakpoint0.40.63.82.0-0.20.2-0.60.60.5-0.20.4-0.5
Progressive ratio test 2 inactive lever presses0.41.310.83.30.5-0.50.1-0.1-0.20.4-0.40.2
Incentive Sensitization - Responses0.10.32.6-1.60.0-0.30.2-0.2-0.10.3-0.10.1
Incentive Sensitization - Breakpoint0.10.32.9-1.7-0.1-0.10.1-0.1-0.00.20.1-0.0
Sum of active levers in priming session hrs 5-61.01.01.2-1.00.8-1.01.1-1.1-1.01.1-0.91.0
Progressive ratio0.00.00.10.10.1-0.20.1-0.1-0.10.3-0.10.1
Food seeking constrained by brief footshock0.60.73.7-1.9-0.80.7-0.50.50.6-0.50.6-0.6
Seeking ratio, punishment vs. effort0.30.60.9-0.3-0.80.9-0.80.80.8-1.00.8-0.8
Retroperitoneal fat weight0.20.73.2-1.80.7-0.70.7-0.7-0.60.6-0.50.6
Reaction time number correct0.10.21.3-1.10.3-0.00.3-0.3-0.20.1-0.20.2
Reaction time mean minus median0.10.71.0-0.50.6-0.61.0-1.0-0.90.8-0.90.9
Reaction time mean minus median AUC0.10.51.2-1.10.4-0.40.8-0.8-0.70.6-0.70.7
Reaction time num false alarms0.81.44.6-2.10.7-0.91.2-1.2-1.10.9-0.91.1
Reaction time num false alarms AUC0.71.62.7-1.60.9-1.11.4-1.3-1.21.2-1.11.3
Reaction time trials correct on left0.10.21.3-1.10.3-0.00.3-0.3-0.20.1-0.20.2
Reaction time trials on left0.10.21.2-1.10.3-0.00.3-0.3-0.20.0-0.20.2
Reaction time mean0.20.40.60.30.6-0.50.7-0.7-0.70.6-0.70.7
Reaction time mean AUC0.40.91.10.70.9-0.81.0-1.1-1.00.9-1.11.1
Median of all reaction times0.30.50.60.70.7-0.60.7-0.7-0.70.6-0.80.8
Reaction time omissions0.20.40.50.70.7-0.40.6-0.6-0.60.6-0.60.6
Reaction time false alarm rate0.70.91.1-0.90.7-1.01.1-1.0-1.01.1-0.91.0
Reaction time premature initiation rate0.20.30.4-0.3-0.60.6-0.50.50.5-0.70.5-0.5
Reaction time premature initiations0.10.20.9-0.9-0.40.6-0.30.30.3-0.60.3-0.3
Std. dev. reaction times0.30.91.2-0.20.8-0.71.1-1.1-1.10.9-1.11.1
Reaction time trials completed0.10.21.2-1.10.3-0.00.3-0.3-0.20.0-0.20.2
Reaction time trials AUC0.10.21.4-1.20.20.10.2-0.2-0.1-0.0-0.10.1
Run reversals in cocaine runway, females1.72.02.4-0.11.3-1.61.5-1.5-1.51.5-1.51.5
Run reversals in cocaine runway, males1.31.43.8-1.9-1.11.1-1.01.01.1-1.01.1-1.1
Latency to leave start box in cocaine runway0.00.00.2-0.5-0.40.1-0.00.00.10.10.1-0.1
Latency to leave start box in cocaine runway, F0.30.40.70.50.5-0.70.7-0.7-0.70.8-0.70.7
Latency to leave start box in cocaine runway, M0.80.71.2-0.6-1.10.9-0.80.80.9-0.70.9-0.8
Std. dev. time between licks in bursts0.81.51.80.3-1.31.3-1.31.31.3-1.31.3-1.3
Total sessions with >9 infusions1.31.613.93.70.1-0.2-0.30.20.10.3-0.1-0.0
Short access day 1 total inactive lever presses0.51.01.1-0.21.0-1.01.1-1.1-1.01.1-1.01.1
Short access day 10 total inactive lever presses0.10.71.6-1.30.6-0.80.9-0.9-0.80.8-0.70.8
Short access day 1 total infusions0.51.08.62.90.00.1-0.50.40.3-0.10.2-0.3
Short access day 10 total infusions0.10.10.30.00.2-0.40.4-0.4-0.30.6-0.30.3
Short access total infusions0.50.65.52.40.00.0-0.30.30.20.00.1-0.2
Short access day 1 locomotion2.23.727.95.3-0.50.5-1.11.10.9-0.50.6-0.8
Short access day 10 total locomotion0.20.71.30.50.7-0.90.8-0.8-0.81.1-0.80.8
Short access total locomotion0.71.19.13.0-0.30.1-0.40.40.3-0.00.1-0.3
One hour access (0.3 mA shock)3.03.627.25.2-0.10.4-1.21.10.9-0.50.6-0.9
Compulsive drug intake0.10.21.81.40.0-0.1-0.10.10.00.1-0.0-0.1
One hour access (shock baseline)0.51.210.13.20.30.0-0.40.40.2-0.10.1-0.2
Social response proportion0.30.40.50.10.6-0.70.6-0.6-0.60.7-0.60.6
Social responses0.50.70.8-0.9-0.80.8-0.80.80.8-0.80.9-0.9
Social time0.20.30.60.30.8-0.50.6-0.6-0.60.4-0.60.6
Soleus weight0.71.97.5-2.7-1.51.2-0.90.91.0-1.11.1-1.0
Bone: stiffness0.30.60.7-0.4-0.80.8-0.80.80.8-0.80.8-0.8
Tibialis anterior weight0.30.95.8-2.4-0.70.7-0.30.30.4-0.60.5-0.4
Time to tail flick, vehicle, before self-admin1.41.713.23.61.0-0.40.2-0.2-0.40.3-0.50.4
Time to tail flick, vehicle, after self-admin0.51.01.80.5-0.51.0-1.11.11.0-1.31.0-1.1
Time to tail flick, test, before self-admin0.50.50.7-0.80.4-0.60.8-0.8-0.80.7-0.70.7
Time to tail flick, test, after self-admin0.60.65.2-2.3-0.40.2-0.10.10.20.10.3-0.2
Delta time to tail flick, vehicle, before/after SA3.73.915.4-3.9-1.91.6-1.31.41.5-1.71.7-1.5
Delta time to tail flick, test, before/after SA1.82.22.6-0.5-1.51.6-1.61.61.6-1.51.6-1.6
Tibia length2.56.97.90.62.7-2.72.8-2.8-2.82.8-2.82.8
Ambulatory time before self-admin0.30.91.1-0.5-1.00.9-1.01.01.0-1.01.0-1.0
Ambulatory time after self-admin0.20.32.7-1.6-0.10.0-0.00.00.1-0.10.1-0.1
Bone: tissue strength0.20.21.91.40.10.3-0.20.20.1-0.20.0-0.1
Total heroin consumption0.81.01.2-0.61.0-1.01.1-1.0-1.01.1-1.01.0
Bone: trabecular number0.20.30.4-0.10.6-0.50.6-0.6-0.60.5-0.60.6
Bone: trabecular spacing0.00.00.00.2-0.0-0.1-0.10.00.00.10.0-0.0
Bone: trabecular thickness0.10.10.6-0.80.10.10.3-0.2-0.2-0.1-0.20.2
Bone: trabecular tissue density0.00.10.1-0.2-0.20.2-0.30.30.3-0.20.3-0.3
Water consumed over 24 hours0.00.10.7-0.90.10.10.1-0.1-0.1-0.2-0.00.1
Number of responses in last shaping day0.81.09.23.00.1-0.1-0.30.20.10.2-0.0-0.1