Hub : Genes

Slc5a5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Slc5a5 0.05 0.04 4.9e-04 0.04 0.04 0.03 0.04 7.6e-05 4.7e-05 7.7e-04 3.0e-04
2 PL gene expression Slc5a5 0.32 0.12 0.0e+00 0.28 0.28 0.29 0.29 1.1e-30 3.4e-31 6.9e-32 7.4e-32
3 Brain gene expression Slc5a5 0.49 0.1 0.0e+00 0.61 0.59 0.61 0.62 6.3e-71 9.3e-68 2.7e-72 3.9e-73
4 IC gene expression Slc5a5 0.3 0.11 1.6e-15 0.32 0.32 0.33 0.34 5.4e-14 5.5e-14 2.0e-14 3.5e-15
5 NAcc gene expression Slc5a5 0.08 0.05 3.5e-13 0.09 0.09 0.08 0.09 5.0e-14 3.5e-13 7.3e-12 1.9e-13
6 pVTA gene expression Slc5a5 0.26 0.11 0.0e+00 0.29 0.29 0.29 0.3 1.4e-23 1.3e-23 2.0e-23 2.4e-24
7 OFC mRNA stability Slc5a5 0.23 0.13 6.0e-04 0.2 0.11 0.2 0.07 1.9e-05 1.5e-03 1.9e-05 7.6e-03
8 IL gene expression Slc5a5 0.65 0.13 7.5e-12 0.23 0.26 0.26 0.25 2.7e-06 6.0e-07 6.0e-07 1.1e-06
9 OFC gene expression Slc5a5 0.41 0.15 8.9e-09 0.19 0.23 0.26 0.2 2.5e-05 3.8e-06 6.0e-07 2.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.32.6-1.6-1.5-1.0-1.2-1.2-1.20.4-0.9-0.2
Area under the delay curve0.20.21.30.40.00.2-0.1-0.1-0.0-1.1-0.3-0.5
BMI with tail1.03.67.8-2.8-1.8-2.1-1.9-1.9-1.91.8-1.3-0.8
BMI without tail2.47.312.3-3.5-3.0-2.9-2.9-2.9-2.90.6-2.4-2.1
Body weight3.716.230.7-5.5-4.3-4.4-4.4-4.4-4.22.3-3.1-2.4
Weight adjusted by age1.62.53.9-2.0-1.5-1.7-1.9-1.9-1.70.6-1.3-1.1
Bone surface0.20.51.8-0.9-0.6-0.5-0.5-0.5-0.41.3-0.10.4
Bone volume0.81.42.8-1.7-1.4-1.1-1.3-1.3-1.30.9-0.8-0.3
Breakpoint value in progressive ratio session0.30.41.70.10.70.30.30.30.31.30.50.6
Number of licking bursts0.00.00.20.40.20.20.20.20.2-0.30.10.1
Context. condit. distance diff. score0.10.20.5-0.3-0.7-0.4-0.3-0.3-0.3-0.4-0.4-0.3
Locomotion velocity, session 12.32.58.40.41.40.91.41.41.42.91.71.8
Locomotion distance, session 13.44.36.31.32.11.82.02.02.02.52.32.4
Locomotion velocity, session 20.70.82.2-1.5-0.8-1.0-0.9-0.9-0.80.9-0.7-0.5
Locomotion distance, session 23.34.66.41.52.32.12.12.12.12.32.42.5
Locomotion velocity, session 30.20.20.30.30.20.50.50.50.50.30.40.5
Locomotion distance, session 30.80.81.30.60.70.80.90.91.01.01.01.1
Stereotopy head waving bouts, day 30.10.10.20.30.00.40.40.40.40.10.30.5
Stereotopy head waving duration, day 30.00.00.1-0.1-0.3-0.00.00.00.0-0.0-0.1-0.0
Locomotion velocity, session 71.21.32.01.41.41.21.11.11.10.41.21.0
Locomotion distance, session 71.21.52.91.71.51.41.21.21.2-0.31.11.0
Stereotopy head waving bouts, day 70.30.31.7-0.8-0.5-0.3-0.1-0.1-0.11.3-0.00.3
Stereotopy head waving duration, day 70.60.71.9-1.4-1.1-0.9-0.7-0.7-0.70.8-0.7-0.4
Locomotion velocity, session 81.51.82.80.81.21.21.21.21.31.71.51.6
Locomotion distance, session 81.11.73.30.61.11.11.21.21.21.81.51.7
Degree of sensitization distance0.30.31.20.90.50.50.20.20.1-1.10.1-0.1
Degree of sensitization stereotypy0.40.52.5-1.0-0.4-0.5-0.3-0.3-0.31.6-0.00.2
Conditioned locomotion0.10.10.20.40.40.00.50.50.4-0.20.10.0
Cocaine response after cond. corrected1.51.97.9-0.1-1.0-0.8-1.0-1.0-1.0-2.8-1.4-1.5
Cocaine response after cond. not corrected0.60.74.60.4-0.4-0.1-0.4-0.4-0.5-2.1-0.7-0.8
Cocaine response before conditioning1.92.33.80.91.61.41.41.41.42.01.61.7
Saline control response0.40.52.1-0.10.40.50.30.30.31.50.71.0
Bone: connectivity density0.20.30.8-0.9-0.7-0.6-0.4-0.4-0.40.5-0.30.0
Bone: cortical apparent density0.10.10.20.20.10.40.30.30.4-0.40.20.2
Bone: cortical area5.28.013.2-3.6-3.3-2.9-3.1-3.1-3.11.2-2.3-1.9
Bone: cortical porosity1.21.34.30.51.20.70.80.80.82.11.31.3
Bone: cortical porosity1.21.34.50.41.10.70.80.80.82.11.21.3
Bone: cortical thickness3.55.810.6-3.3-2.9-2.4-2.6-2.6-2.61.6-1.7-1.2
Bone: cortical thickness2.22.64.4-2.0-2.1-1.6-1.8-1.8-1.80.5-1.3-0.9
Bone: cortical tissue density0.10.20.30.30.30.50.50.50.5-0.40.30.3
Condit. Reinf. active minus inactive responses0.40.42.2-0.8-0.4-0.4-0.4-0.4-0.31.50.00.2
Condit. Reinf. active-inactive response ratio0.20.20.5-0.6-0.7-0.4-0.6-0.6-0.50.3-0.4-0.3
Condit. Reinf. active responses0.50.62.9-1.0-0.4-0.6-0.5-0.5-0.51.7-0.00.2
Condit. Reinf. inactive responses0.10.20.6-0.6-0.1-0.5-0.4-0.4-0.40.8-0.1-0.1
Incentive salience index mean0.81.06.8-1.2-0.2-0.4-0.3-0.3-0.22.60.30.7
Condit. Reinf. lever presses1.31.812.6-1.4-0.0-0.30.00.00.13.60.71.2
Condit. Reinf. active minus inactive responses0.30.41.00.30.60.60.40.40.51.00.80.9
Condit. Reinf. active-inactive response ratio0.30.30.5-0.7-0.5-0.5-0.6-0.6-0.60.5-0.3-0.2
Condit. Reinf. active responses1.11.51.91.11.41.41.11.11.21.01.41.4
Condit. Reinf. inactive responses2.02.53.92.01.91.81.61.61.7-0.01.51.3
Condit. Reinf. lever presses0.00.10.1-0.3-0.2-0.2-0.3-0.3-0.3-0.2-0.3-0.2
Condit. Reinf. lever reinforcers received0.20.30.50.60.70.70.40.40.50.40.60.6
Conditioned reinforcement - actives1.01.72.5-1.4-1.3-1.6-1.3-1.3-1.3-0.6-1.3-1.3
Conditioned reinforcement - inactives6.08.811.6-3.2-2.9-3.4-3.2-3.2-3.2-0.7-3.0-2.9
Conditioned locomotion2.02.63.1-1.4-1.7-1.7-1.6-1.6-1.6-1.5-1.7-1.7
Patch foraging indifference point 0 sec2.03.75.2-2.3-2.1-2.2-2.1-2.1-2.1-0.1-1.8-1.7
Patch foraging indifference point AUC0.10.10.90.00.2-0.00.10.10.0-1.0-0.4-0.3
Delay disc. indifference point, 0s delay1.61.82.71.61.51.71.41.41.4-0.51.21.1
Delay disc. indifference point, 16s delay0.80.94.51.20.60.70.40.40.5-2.1-0.1-0.4
Delay disc. indifference point, 2s delay0.70.71.00.91.01.00.80.80.80.70.90.8
Delay disc. indifference point, 24s delay0.40.41.4-0.3-0.6-0.4-0.6-0.6-0.5-1.2-0.7-0.8
Delay disc. indifference point, 4s delay0.10.10.3-0.1-0.10.20.00.0-0.00.60.20.3
Delay disc. indifference point, 8s delay0.91.03.5-0.1-0.7-0.5-0.8-0.8-0.7-1.9-1.1-1.3
Indifference point function ln k0.20.40.7-0.6-0.9-0.7-0.5-0.5-0.60.8-0.2-0.5
Indifference point function log k0.20.40.7-0.6-0.9-0.7-0.5-0.5-0.60.8-0.2-0.5
Patch foraging total patch changes 0 sec3.05.77.9-2.8-2.6-2.7-2.5-2.5-2.6-0.2-2.3-2.1
Patch foraging total patch changes 12 sec1.31.72.2-1.4-1.2-1.3-1.3-1.3-1.3-1.0-1.5-1.2
Patch foraging total patch changes 18 sec0.10.10.90.10.3-0.1-0.1-0.1-0.1-0.9-0.3-0.2
Patch foraging total patch changes 24 sec0.20.40.7-0.7-0.3-0.8-0.6-0.6-0.6-0.1-0.7-0.5
Patch foraging total patch changes 6 sec1.82.73.6-1.9-1.6-1.7-1.8-1.8-1.7-0.7-1.6-1.4
Patch foraging time to switch 0 sec0.71.42.51.21.51.60.90.91.10.41.31.5
Patch foraging water rate 0 sec0.61.32.7-1.6-1.6-1.4-0.9-0.9-1.00.7-0.9-1.0
Patch foraging water rate 12 sec0.10.30.9-0.7-0.6-0.6-0.3-0.3-0.31.0-0.1-0.2
Patch foraging water rate 18 sec0.71.13.20.50.80.70.90.90.91.81.21.1
Patch foraging water rate 24 sec0.60.84.9-0.7-0.2-0.10.40.40.42.20.70.7
Patch foraging water rate 6 sec0.71.01.7-1.2-1.3-1.3-0.8-0.8-0.90.4-0.8-1.1
Seeking ratio, delayed vs. immediate footshock0.80.91.30.50.31.11.11.11.00.91.11.1
Distance traveled before self-admin0.70.91.5-1.2-1.0-0.9-1.2-1.2-1.10.5-0.7-0.6
Distance traveled after self-admin0.91.12.1-1.4-1.1-1.0-1.1-1.1-1.01.4-0.5-0.3
Extensor digitorum longus weight0.41.53.3-1.8-1.5-1.2-1.3-1.3-1.30.6-0.9-0.5
Bone: elastic displacement0.70.82.20.30.70.70.60.60.71.51.01.1
Bone: elastic work1.72.23.5-1.9-1.8-1.4-1.6-1.6-1.60.7-1.2-0.9
Bone: endosteal estimation0.10.31.00.0-0.1-0.4-0.4-0.4-0.4-1.0-0.7-0.8
Bone: endosteal perimeter0.61.31.7-1.0-1.1-1.3-1.3-1.3-1.3-0.2-1.2-1.3
Epididymis fat weight0.41.32.9-1.7-1.4-1.1-1.1-1.1-1.01.0-0.7-0.6
Delta time in closed arm before/after self-admin0.60.52.3-0.0-0.3-0.4-0.4-0.4-0.5-1.5-0.8-1.0
Delta time in open arm before/after self-admin0.60.60.90.80.80.90.70.70.90.30.90.9
Diff in mean of infusions in LGA sessions1.01.21.5-1.2-1.2-1.2-1.2-1.2-1.2-0.1-1.0-1.0
Delay discount exponential model param0.20.20.9-0.10.20.10.40.40.31.00.50.6
Extinction: sum of active levers before priming1.21.32.30.71.01.20.90.91.01.51.31.5
Active lever presses in extinction session 60.10.10.20.30.30.50.30.30.40.00.40.4
Bone: final force6.610.515.4-3.9-3.5-3.5-3.5-3.5-3.50.2-3.1-2.7
Bone: final moment6.310.113.7-3.7-3.4-3.5-3.5-3.5-3.5-0.1-3.1-2.8
Food consumed during 24 hour testing period1.01.33.10.51.10.90.90.90.91.81.21.5
Glucose0.81.32.2-1.5-1.3-1.3-1.1-1.1-1.10.2-1.1-1.1
Heart weight1.31.93.3-1.8-1.3-1.4-1.5-1.5-1.51.7-0.8-0.4
Delay discount hyperbolic model param0.10.10.4-0.00.20.10.30.30.30.60.40.5
Intermittent access intake day 1-15 change0.10.10.7-0.4-0.2-0.3-0.1-0.1-0.10.90.00.1
Intermittent access intake escalation0.10.11.0-0.10.0-0.10.20.20.21.00.30.4
Intermittent access intake escalation 20.30.30.6-0.7-0.8-0.6-0.5-0.5-0.50.5-0.4-0.3
Intermitt. access day 1 inactive lever presses0.10.30.4-0.7-0.6-0.6-0.6-0.6-0.5-0.2-0.5-0.5
Intermitt. access day 15 inactive lever presses0.00.10.30.20.5-0.00.30.30.20.40.30.3
Intermitt. access escalation Index0.30.40.80.90.70.90.60.60.6-0.20.50.5
Intermittent access day 1 total infusions1.01.73.2-0.8-1.0-1.5-1.0-1.0-1.1-1.8-1.5-1.7
Intermittent access day 15 total infusions0.10.20.5-0.3-0.4-0.7-0.3-0.3-0.4-0.3-0.5-0.6
Intermittent access terminal intake (last 3 days)0.20.30.5-0.2-0.3-0.7-0.4-0.4-0.5-0.6-0.6-0.7
Intermittent access total infusions1.51.82.7-1.0-1.2-1.6-1.2-1.2-1.3-1.4-1.5-1.7
Intermittent access day 1 locomotion2.02.63.8-1.3-1.5-2.0-1.5-1.5-1.5-1.6-1.7-1.9
Intermittent access day 15 total locomotion0.10.10.4-0.2-0.2-0.6-0.2-0.2-0.2-0.5-0.4-0.5
Intermittent access total locomotion2.32.73.8-1.4-1.7-2.0-1.6-1.6-1.6-1.4-1.7-1.8
Intermittent access standard deviation0.10.30.4-0.5-0.7-0.6-0.5-0.5-0.5-0.4-0.5-0.5
Left kidney weight0.31.63.7-1.9-1.3-1.3-1.3-1.3-1.21.1-0.8-0.5
Right kidney weight0.83.78.0-2.8-2.0-2.0-2.0-2.0-2.01.2-1.5-1.1
Cocaine induced anxiety1.31.92.5-1.4-1.4-1.6-1.5-1.5-1.5-0.5-1.3-1.3
Post-drug Anxiety0.10.10.1-0.3-0.2-0.2-0.4-0.4-0.3-0.1-0.2-0.2
Baseline Anxiety2.83.24.61.81.82.11.91.91.90.71.81.8
Tail length0.83.35.3-2.3-2.2-1.7-2.0-2.0-2.00.3-1.6-1.4
Length with tail1.66.912.3-3.5-2.9-2.7-2.9-2.9-2.81.1-2.1-1.7
Length without tail1.23.87.1-2.7-2.0-2.2-2.2-2.2-2.11.2-1.5-1.0
Times rat made contact with spout0.30.40.60.60.70.60.60.60.50.60.60.8
Lifetime Intake2.32.83.9-1.5-1.6-2.0-1.7-1.7-1.7-1.2-1.8-1.9
Liver weight, left0.81.33.30.50.71.11.01.01.11.81.31.4
Liver weight, right0.71.32.9-1.7-1.0-1.2-1.3-1.3-1.20.6-0.9-0.6
Locomotor activity0.91.58.3-0.30.30.60.40.40.52.91.21.5
Locomotor testing distance0.61.13.30.30.50.90.80.80.81.81.21.3
Locomotor testing rearing0.71.54.00.61.01.10.90.90.92.01.31.6
Locomotion in novel chamber0.10.10.4-0.4-0.4-0.1-0.2-0.2-0.00.70.10.2
Locomotion in novel chamber post-restriction0.50.84.00.00.60.40.40.40.42.00.91.2
Fecal boli incidents, locomotor time 10.20.20.80.70.30.40.50.50.4-0.90.20.0
Change in fecal boli incidents, locomotor task0.30.30.70.70.80.50.60.60.6-0.20.40.3
Time >=10cm from walls, locomotor time 10.10.11.00.2-0.2-0.1-0.1-0.1-0.1-1.0-0.2-0.4
Bouts of movement, locomotor time 10.70.81.20.81.10.90.90.90.80.60.80.8
Total resting periods, locomotor time 11.31.52.31.21.51.31.31.31.20.61.11.1
Rest time, locomotor task time 10.10.10.20.30.40.10.30.30.2-0.3-0.1-0.2
Distance moved, locomotor task time 10.00.10.20.1-0.2-0.0-0.3-0.3-0.2-0.4-0.1-0.1
Vertical activity count, locomotor time 10.10.10.5-0.3-0.40.2-0.2-0.2-0.10.70.30.5
Time >=10cm from walls, locomotor time 20.40.60.90.90.30.70.90.90.8-0.90.60.5
Bouts of movement, locomotor time 20.20.20.70.10.60.30.40.40.40.90.50.6
Total resting periods, locomotor time 20.10.10.50.00.50.20.30.30.20.70.30.4
Rest time, locomotor task time 20.30.40.5-0.7-0.3-0.5-0.7-0.7-0.70.3-0.6-0.7
Distance moved, locomotor task time 20.10.21.10.5-0.20.20.10.10.1-1.1-0.0-0.1
Vertical activity count, locomotor time 20.10.21.0-0.2-1.0-0.1-0.4-0.4-0.3-0.1-0.10.0
Light reinforcement 10.10.21.00.2-0.0-0.1-0.1-0.1-0.2-1.0-0.4-0.6
Light reinforcement 21.62.49.7-0.2-1.0-0.8-1.1-1.1-1.2-3.1-1.6-1.9
Bone: marrow area0.10.20.90.1-0.1-0.3-0.3-0.3-0.3-0.9-0.6-0.7
Bone: maximum diameter2.44.56.0-2.4-2.5-2.2-2.4-2.4-2.40.2-1.9-1.8
Bone: maximum force5.29.215.7-4.0-3.3-3.2-3.4-3.4-3.31.4-2.5-2.0
Bone: maximum moment4.68.112.9-3.6-3.1-3.0-3.2-3.2-3.11.0-2.4-2.0
Mean time between licks in bursts1.12.74.1-2.0-1.6-1.7-1.9-1.9-1.80.3-1.4-1.4
Mean num. licks in bursts0.00.10.4-0.10.20.00.00.00.00.60.20.3
Cd content in liver1.92.12.8-1.2-1.6-1.3-1.7-1.7-1.7-1.0-1.5-1.5
Co content in liver0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.10.1-0.10.1
Cu content in liver3.03.55.11.31.61.51.91.91.92.32.12.2
Fe content in liver0.60.71.01.00.91.00.90.90.9-0.30.60.6
K content in liver1.61.63.01.71.41.41.31.31.3-0.31.11.0
Mg content in liver0.10.10.20.50.20.20.40.40.30.00.30.2
Mn content in liver0.20.21.1-0.00.20.00.30.30.31.00.30.2
Na content in liver3.63.84.51.81.92.12.12.12.11.22.12.1
Rb content in liver3.13.64.5-1.3-1.9-1.8-1.9-1.9-1.9-2.0-2.1-2.1
Se content in liver0.50.61.00.50.30.60.80.80.81.00.80.8
Sr content in liver0.30.20.50.60.70.50.50.50.5-0.10.40.3
Zn content in liver0.20.20.50.30.40.30.50.50.40.70.50.5
Bone: minimum diameter1.62.94.4-2.1-2.0-1.7-2.0-2.0-1.90.4-1.4-1.3
Time in familiar zone, hab. session 10.00.00.1-0.30.0-0.3-0.0-0.0-0.0-0.1-0.2-0.2
Time in novel zone, hab. session 10.00.00.10.0-0.3-0.0-0.1-0.1-0.2-0.0-0.1-0.1
Total zone transitions, hab. session 11.11.51.80.91.31.11.21.21.21.31.31.3
Total locomotion distance, hab. session 13.04.35.01.52.21.92.12.12.12.12.22.2
Locomotion velocity, hab. session 13.14.35.31.62.31.92.12.12.12.12.22.2
Time in familiar zone, hab. session 20.10.10.1-0.2-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3
Time in novel zone, hab. session 20.00.00.10.1-0.1-0.0-0.1-0.1-0.0-0.3-0.2-0.2
Total zone transitions, hab. session 20.40.50.70.60.90.50.70.70.70.80.70.7
Total locomotion distance, hab. session 21.11.54.20.51.20.81.01.01.02.11.41.4
Locomotion velocity, hab. session 21.41.94.60.61.31.01.11.11.12.21.51.6
Novel to familiar place preference ratio0.50.62.3-0.1-0.6-0.4-0.4-0.4-0.4-1.5-0.8-1.0
Novelty place preference0.40.42.00.1-0.4-0.3-0.2-0.2-0.3-1.4-0.7-0.9
Time in novel zone, NPP test0.20.21.60.4-0.10.00.00.00.0-1.3-0.4-0.6
Total zone transitions, NPP test1.62.32.71.11.51.31.61.61.61.61.61.6
Total locomotion distance, NPP test3.24.46.11.52.01.92.02.02.02.52.32.4
Locomotion velocity, NPP test2.84.05.11.52.01.82.02.01.92.22.22.3
Intraocular pressure1.82.63.7-1.5-1.9-1.6-1.6-1.6-1.6-1.0-1.7-1.7
Delta distance traveled before/after self-admin0.40.41.0-0.8-0.6-0.5-0.6-0.6-0.51.0-0.3-0.2
Delta ambulatory time before/after self-admin0.10.10.4-0.3-0.3-0.2-0.2-0.2-0.10.6-0.1-0.0
Parametrial fat weight3.27.610.5-2.6-2.7-2.9-2.7-2.7-2.8-2.1-3.0-3.2
Pavlov. Cond. lever latency0.91.17.20.9-0.0-0.2-0.1-0.1-0.2-2.7-0.7-1.3
Pavlov. Cond. magazine entry latency0.30.40.6-0.8-0.7-0.5-0.7-0.7-0.7-0.0-0.5-0.3
Pavlov. Cond. change in total contacts1.31.43.2-1.8-1.3-1.0-1.3-1.3-1.21.2-0.7-0.3
Pavlov. Cond. index score0.40.52.8-0.6-0.00.2-0.0-0.00.01.70.50.9
Pavlov. Cond. latency score0.60.74.1-0.60.10.30.10.10.22.00.71.1
Pavlov. Cond. lever contacts0.70.85.4-1.0-0.10.1-0.1-0.1-0.02.30.51.0
Pavlov. Cond. magazine entry number0.30.40.80.90.70.50.70.70.7-0.10.50.3
Pavlov. Cond. intertrial magazine entries0.40.42.7-0.00.20.20.10.10.21.60.60.9
Pavlov. Cond. lever-magazine prob. diff.0.30.32.0-0.6-0.10.1-0.1-0.1-0.11.40.30.7
Pavlov. Cond. response bias0.20.31.0-0.8-0.5-0.3-0.5-0.5-0.41.0-0.10.2
Pavlov. Cond. lever latency0.91.31.91.41.31.01.31.31.20.21.11.0
Pavlov. Cond. magazine entry latency1.21.42.3-1.4-1.5-1.0-1.3-1.3-1.2-0.7-1.2-0.9
Pavlov. Cond. change in total contacts0.91.42.2-1.5-1.3-1.1-1.4-1.4-1.3-0.1-1.1-0.8
Pavlov. Cond. index score1.72.23.1-1.7-1.8-1.4-1.7-1.7-1.6-0.6-1.5-1.3
Pavlov. Cond. latency score1.11.52.2-1.5-1.5-1.0-1.4-1.4-1.3-0.6-1.2-1.0
Pavlov. Cond. lever contacts0.81.11.7-1.3-1.2-0.9-1.1-1.1-1.1-0.2-1.0-0.8
Pavlov. Cond. magazine entry number2.43.04.32.02.11.51.91.91.80.71.71.4
Pavlov. Cond. intertrial magazine entries1.62.43.71.81.91.41.61.61.60.91.61.4
Pavlov. Cond. lever-magazine prob. diff.1.82.43.4-1.8-1.8-1.4-1.7-1.7-1.7-0.5-1.5-1.3
Pavlov. Cond. response bias1.21.62.3-1.5-1.5-1.2-1.4-1.4-1.4-0.2-1.2-1.1
Time in closed arm before self-admin5.16.59.7-3.1-2.9-2.9-2.8-2.8-2.60.4-2.3-2.0
Time in closed arm after self-admin6.36.88.3-2.3-2.8-2.8-2.6-2.6-2.6-1.8-2.8-2.9
Time in open arm before self-admin2.02.23.81.01.61.41.31.31.32.01.61.8
Time in open arm after self-admin4.34.78.91.21.82.01.81.81.93.02.52.9
Bone: periosteal estimation1.53.14.1-2.0-2.0-1.8-2.0-2.0-2.00.1-1.6-1.5
Bone: periosteal perimeter4.06.88.8-3.0-2.9-2.8-2.9-2.9-2.90.1-2.4-2.3
Bone: post-yield work0.20.30.90.40.50.40.30.30.30.90.50.6
Progressive ratio test 1 active lever presses2.43.04.9-1.9-1.7-2.2-1.8-1.8-1.8-0.3-1.7-1.6
Progressive ratio test 1 breakpoint2.12.64.4-1.8-1.6-2.1-1.7-1.7-1.7-0.3-1.6-1.5
Progressive ratio test 1 inactive lever presses0.91.32.3-1.5-1.2-1.5-1.1-1.1-1.10.3-1.0-0.9
Progressive ratio test 2 active lever presses1.11.32.0-0.8-1.0-1.3-1.1-1.1-1.1-1.2-1.3-1.4
Progressive ratio test 2 breakpoint0.91.01.6-0.6-0.9-1.1-0.9-0.9-0.9-1.2-1.1-1.2
Progressive ratio test 2 inactive lever presses0.71.12.1-1.2-0.8-1.5-1.1-1.1-1.10.0-1.1-1.0
Incentive Sensitization - Responses0.40.53.30.50.0-0.2-0.1-0.1-0.1-1.8-0.6-0.9
Incentive Sensitization - Breakpoint0.40.53.40.70.20.00.10.10.1-1.8-0.5-0.8
Sum of active levers in priming session hrs 5-64.23.95.12.12.22.32.02.02.10.92.02.0
Progressive ratio0.00.10.50.20.30.2-0.0-0.0-0.0-0.7-0.1-0.2
Food seeking constrained by brief footshock0.10.10.40.60.50.50.20.20.40.10.30.3
Seeking ratio, punishment vs. effort0.40.61.30.50.50.60.80.80.81.10.80.9
Retroperitoneal fat weight2.39.713.7-3.6-3.7-3.4-3.2-3.2-3.2-0.5-3.0-3.1
Reaction time number correct1.22.37.90.31.11.01.11.11.22.81.71.9
Reaction time mean minus median0.00.00.10.10.30.20.20.20.20.10.20.1
Reaction time mean minus median AUC0.00.00.10.10.3-0.00.10.10.20.20.1-0.0
Reaction time num false alarms0.91.21.5-1.0-1.2-1.2-1.1-1.1-1.2-0.7-1.2-1.2
Reaction time num false alarms AUC0.61.01.2-0.8-1.1-1.0-1.0-1.0-1.0-0.8-1.1-1.1
Reaction time trials correct on left1.22.37.90.31.11.01.11.11.22.81.71.9
Reaction time trials on left1.22.27.90.21.10.91.11.11.12.81.61.9
Reaction time mean1.52.44.7-0.8-1.3-1.3-1.5-1.5-1.4-2.2-1.7-1.9
Reaction time mean AUC0.71.24.1-0.2-0.7-0.7-0.8-0.8-0.8-2.0-1.2-1.5
Median of all reaction times2.33.37.3-0.8-1.5-1.4-1.7-1.7-1.7-2.7-2.0-2.3
Reaction time omissions0.60.91.3-1.1-0.7-1.1-1.0-1.0-1.0-0.2-1.0-0.9
Reaction time false alarm rate1.82.43.3-1.0-1.6-1.4-1.5-1.5-1.5-1.8-1.7-1.8
Reaction time premature initiation rate0.81.12.90.41.00.70.80.80.91.71.11.3
Reaction time premature initiations1.32.38.00.31.30.91.11.11.22.81.71.9
Std. dev. reaction times0.20.40.6-0.6-0.5-0.7-0.6-0.6-0.6-0.5-0.7-0.8
Reaction time trials completed1.22.27.90.21.10.91.11.11.12.81.61.9
Reaction time trials AUC0.91.76.90.10.90.70.90.90.92.61.41.6
Run reversals in cocaine runway, females2.62.63.7-1.8-1.6-1.9-1.8-1.8-1.70.3-1.6-1.5
Run reversals in cocaine runway, males1.71.82.11.31.51.41.41.41.31.01.31.3
Latency to leave start box in cocaine runway0.00.10.40.00.6-0.00.10.10.1-0.10.10.1
Latency to leave start box in cocaine runway, F0.10.20.6-0.50.4-0.4-0.2-0.2-0.30.8-0.10.0
Latency to leave start box in cocaine runway, M0.50.52.70.90.40.40.40.40.5-1.70.1-0.2
Std. dev. time between licks in bursts1.52.13.0-1.7-1.5-1.5-1.6-1.6-1.60.0-1.4-1.3
Total sessions with >9 infusions3.84.66.8-2.4-2.2-2.6-2.3-2.3-2.3-0.4-2.2-2.0
Short access day 1 total inactive lever presses1.41.92.5-1.2-1.2-1.6-1.3-1.3-1.4-1.2-1.5-1.5
Short access day 10 total inactive lever presses0.10.10.20.40.40.30.40.40.4-0.10.40.4
Short access day 1 total infusions2.83.75.4-2.3-2.0-2.3-2.0-2.0-2.0-0.0-1.8-1.6
Short access day 10 total infusions0.50.71.6-1.0-0.7-1.3-0.7-0.7-0.80.0-0.8-0.7
Short access total infusions1.82.33.6-1.6-1.4-1.9-1.6-1.6-1.6-0.6-1.6-1.6
Short access day 1 locomotion6.48.010.7-3.0-3.1-3.3-2.9-2.9-2.9-1.1-2.9-2.8
Short access day 10 total locomotion0.81.53.7-1.7-1.1-1.4-1.0-1.0-1.01.9-0.4-0.1
Short access total locomotion2.53.04.8-2.0-1.9-2.2-1.8-1.8-1.90.1-1.6-1.4
One hour access (0.3 mA shock)0.91.02.1-0.6-1.1-0.9-0.8-0.8-0.8-1.4-1.1-1.2
Compulsive drug intake0.81.01.81.31.01.11.11.11.1-0.90.60.4
One hour access (shock baseline)2.43.64.4-1.9-2.1-2.1-2.0-2.0-2.0-1.0-1.9-1.9
Social response proportion2.22.53.8-1.9-1.8-1.8-1.7-1.7-1.70.3-1.5-1.1
Social responses0.30.42.4-0.6-0.4-0.2-0.3-0.3-0.31.50.10.5
Social time0.10.20.4-0.4-0.4-0.2-0.5-0.5-0.50.6-0.1-0.0
Soleus weight1.13.14.5-1.6-1.8-1.8-1.7-1.7-1.8-1.4-2.0-2.1
Bone: stiffness4.26.911.6-3.4-2.7-2.8-3.0-3.0-2.90.9-2.3-1.8
Tibialis anterior weight0.20.64.2-0.9-0.0-0.0-0.1-0.1-0.12.00.40.9
Time to tail flick, vehicle, before self-admin0.20.21.10.50.6-0.20.10.1-0.0-1.1-0.2-0.4
Time to tail flick, vehicle, after self-admin0.20.30.6-0.7-0.7-0.5-0.6-0.6-0.60.0-0.5-0.4
Time to tail flick, test, before self-admin2.62.73.5-1.5-1.9-1.8-1.7-1.7-1.8-0.7-1.7-1.7
Time to tail flick, test, after self-admin0.60.73.01.10.80.50.50.50.5-1.70.0-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.9-0.3-0.20.30.10.10.21.00.40.5
Delta time to tail flick, test, before/after SA1.61.62.41.61.51.41.41.41.4-0.51.10.9
Tibia length0.61.62.8-1.7-1.4-1.3-1.5-1.5-1.40.6-1.0-0.7
Ambulatory time before self-admin1.01.62.6-1.6-1.4-1.2-1.5-1.5-1.40.5-0.9-0.8
Ambulatory time after self-admin1.72.03.7-1.9-1.4-1.3-1.5-1.5-1.41.8-0.7-0.4
Bone: tissue strength0.00.00.2-0.20.1-0.2-0.1-0.1-0.10.4-0.0-0.1
Total heroin consumption0.10.10.2-0.1-0.0-0.1-0.4-0.4-0.3-0.2-0.3-0.4
Bone: trabecular number0.81.32.7-1.7-1.4-1.1-1.2-1.2-1.20.5-0.8-0.3
Bone: trabecular spacing0.10.20.50.60.70.40.40.40.4-0.30.20.0
Bone: trabecular thickness0.50.61.2-1.1-1.1-0.6-0.7-0.7-0.70.9-0.2-0.1
Bone: trabecular tissue density1.01.42.20.91.41.21.01.01.01.51.41.3
Water consumed over 24 hours0.30.41.6-0.00.60.20.50.50.41.30.50.8
Number of responses in last shaping day0.10.10.6-0.40.0-0.2-0.1-0.1-0.10.80.10.2