Slc4a10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio XM_006234285.4 0.02 0.01 6.7e-03 0 0 0 0 2.7e-01 9.6e-02 3.5e-01 3.4e-01
2 PL intron excision ratio chr3_46949171_46949945 0.03 0.02 2.0e-03 0.01 0.02 0.02 0.02 7.1e-03 3.5e-03 2.6e-03 3.6e-03
3 OFC intron excision ratio chr3_46949983_46957084 0.11 0.07 8.5e-03 0.1 0.08 0.04 0.09 2.8e-03 6.2e-03 3.4e-02 4.5e-03
4 pVTA intron excision ratio chr3_46949171_46957084 0.12 0.07 4.4e-05 0.12 0.11 0.12 0.11 6.5e-06 2.0e-05 6.5e-06 1.4e-05
5 PL intron excision ratio chr3_46946373_46949055 0.05 0.03 2.4e-05 0.04 0.04 0.04 0.04 7.8e-05 1.6e-05 3.9e-05 2.8e-05
6 Brain intron excision ratio chr3_46868709_46874592 0.03 0.02 1.2e-03 0.02 0.02 0.01 0.01 5.4e-03 5.3e-03 2.8e-02 1.9e-02
7 PL mRNA stability Slc4a10 0.15 0.08 6.8e-11 0.06 0.1 0.1 0.1 1.2e-07 1.3e-10 1.1e-10 3.2e-11
8 BLA intron excision ratio chr3_46946373_46949055 0.06 0.04 1.8e-03 0.03 0.03 -0 0.01 7.5e-03 1.6e-02 6.1e-01 5.9e-02
9 NAcc mRNA stability Slc4a10 0.07 0.04 1.9e-05 0.02 0.03 0.03 0.03 2.3e-03 2.2e-04 1.1e-04 9.8e-05
10 NAcc isoform ratio XM_006234277.4 0.04 0.03 5.0e-04 0.03 0.02 0.03 0.03 1.6e-04 2.4e-03 2.4e-04 4.3e-04
11 PL intron excision ratio chr3_46868709_46874592 0.07 0.05 2.5e-04 0.03 0.03 0.03 0.03 1.9e-04 8.4e-04 4.1e-04 1.7e-04
12 BLA intron excision ratio chr3_46868709_46874592 0.08 0.06 1.6e-03 0.06 0.04 0.06 0.06 3.4e-04 2.5e-03 3.9e-04 5.1e-04
13 Brain mRNA stability Slc4a10 0.14 0.07 2.2e-06 0.07 0.06 0.06 0.06 9.6e-07 3.7e-06 1.6e-06 5.1e-06
14 NAcc gene expression Slc4a10 0.13 0.06 1.8e-15 0.14 0.14 0.14 0.14 2.6e-16 1.2e-15 2.0e-16 2.8e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.40.9-0.40.80.70.91.00.10.6-0.70.30.70.7-0.7-0.0-0.3
Area under the delay curve0.50.51.9-0.4-0.3-0.5-1.0-0.60.0-0.90.9-1.40.00.0-0.11.4-0.3
BMI with tail0.10.41.0-1.0-0.7-0.8-0.6-0.6-0.7-0.60.5-0.8-0.6-0.40.60.60.3
BMI without tail0.20.40.8-0.00.60.40.60.50.50.7-0.7-0.20.70.9-0.80.5-0.9
Body weight0.20.71.21.10.80.80.90.71.01.0-1.00.70.50.7-0.6-0.2-0.7
Weight adjusted by age0.91.13.80.2-0.5-1.0-1.1-1.20.5-1.41.3-2.00.00.10.11.8-0.2
Bone surface1.22.03.20.91.81.51.71.71.21.6-1.60.71.61.6-1.6-0.2-1.2
Bone volume0.61.02.00.11.31.21.31.40.51.2-1.20.71.01.0-1.0-0.4-0.6
Breakpoint value in progressive ratio session6.36.99.8-3.0-3.1-2.7-2.5-2.7-3.0-2.72.8-1.4-2.9-2.92.90.22.4
Number of licking bursts0.20.31.10.1-0.40.1-0.1-0.2-0.50.2-0.10.7-0.6-0.60.6-1.10.7
Context. condit. distance diff. score0.30.31.30.40.2-0.1-0.2-0.20.6-0.40.4-0.90.60.6-0.61.2-0.5
Locomotion velocity, session 10.20.31.20.1-0.30.10.20.0-0.30.2-0.11.0-0.5-0.60.7-1.10.4
Locomotion distance, session 10.00.00.20.4-0.0-0.00.2-0.00.30.2-0.20.00.20.1-0.1-0.2-0.3
Locomotion velocity, session 20.91.01.9-1.4-1.1-1.1-1.2-1.0-1.0-1.21.2-1.0-0.8-0.80.80.60.5
Locomotion distance, session 20.40.50.90.90.70.60.60.50.90.7-0.70.00.90.9-0.90.3-0.8
Locomotion velocity, session 30.20.30.8-0.5-0.5-0.6-0.6-0.5-0.4-0.60.6-0.9-0.3-0.30.30.10.2
Locomotion distance, session 31.01.01.81.01.20.80.70.91.30.7-0.8-0.31.31.4-1.30.6-1.3
Stereotopy head waving bouts, day 30.40.50.70.50.80.80.80.80.50.8-0.80.80.60.6-0.6-0.3-0.4
Stereotopy head waving duration, day 30.20.20.90.40.30.50.50.40.00.5-0.40.90.0-0.1-0.0-0.90.2
Locomotion velocity, session 70.00.00.10.10.1-0.10.00.00.10.0-0.1-0.40.20.2-0.20.2-0.1
Locomotion distance, session 70.10.10.30.4-0.4-0.4-0.3-0.4-0.1-0.10.20.0-0.5-0.50.5-0.40.5
Stereotopy head waving bouts, day 70.20.30.7-0.30.50.50.20.30.4-0.20.1-0.20.70.7-0.70.9-0.7
Stereotopy head waving duration, day 70.10.20.3-0.50.40.40.10.40.1-0.20.1-0.10.50.5-0.60.6-0.5
Locomotion velocity, session 80.10.10.4-0.2-0.1-0.3-0.4-0.20.0-0.50.5-0.60.20.1-0.10.4-0.2
Locomotion distance, session 80.30.41.60.60.1-0.2-0.3-0.50.8-0.50.4-1.10.50.5-0.61.3-0.6
Degree of sensitization distance1.71.72.7-1.0-1.6-1.4-1.3-1.5-1.4-1.21.2-0.3-1.6-1.61.6-0.31.4
Degree of sensitization stereotypy0.30.41.5-0.9-0.2-0.2-0.5-0.4-0.2-0.80.8-0.80.20.2-0.21.2-0.4
Conditioned locomotion0.81.04.50.00.0-0.7-0.8-0.70.7-0.80.7-2.10.80.8-0.91.8-0.8
Cocaine response after cond. corrected7.88.813.3-2.9-3.6-3.1-2.9-3.0-3.4-2.42.5-1.4-3.6-3.53.6-0.93.0
Cocaine response after cond. not corrected5.56.09.4-2.2-3.1-2.7-2.4-2.8-2.6-2.12.2-1.4-2.9-2.92.9-0.32.4
Cocaine response before conditioning1.72.03.61.61.51.01.10.91.90.8-0.9-0.11.91.8-1.91.6-1.6
Saline control response0.10.20.40.3-0.4-0.5-0.3-0.6-0.1-0.40.5-0.2-0.6-0.50.6-0.10.5
Bone: connectivity density0.40.61.00.21.00.80.90.80.60.7-0.80.11.01.0-1.00.3-0.8
Bone: cortical apparent density0.50.63.4-0.20.10.40.40.6-0.60.6-0.41.4-0.6-0.50.5-1.90.7
Bone: cortical area1.52.33.31.81.81.81.61.71.51.6-1.61.71.31.4-1.3-1.0-0.9
Bone: cortical porosity1.21.42.50.61.41.21.61.60.71.5-1.51.40.90.9-0.9-0.9-0.6
Bone: cortical porosity2.52.74.51.31.91.82.12.11.22.0-2.01.81.41.3-1.4-1.2-0.9
Bone: cortical thickness1.32.14.41.21.61.71.71.90.81.7-1.62.10.90.9-0.9-1.8-0.5
Bone: cortical thickness4.55.27.72.22.62.72.72.81.92.7-2.62.41.81.9-1.9-1.6-1.4
Bone: cortical tissue density0.40.63.1-0.30.00.40.40.5-0.70.5-0.41.3-0.6-0.50.6-1.80.7
Condit. Reinf. active minus inactive responses3.33.85.61.92.42.32.02.22.02.0-2.01.32.12.0-2.0-0.2-1.7
Condit. Reinf. active-inactive response ratio1.51.62.61.21.61.41.11.21.51.0-1.10.31.61.6-1.50.5-1.3
Condit. Reinf. active responses3.13.86.21.82.42.52.12.41.72.1-2.11.81.91.8-1.7-1.2-1.4
Condit. Reinf. inactive responses2.12.67.80.71.41.91.72.10.21.9-1.72.60.60.6-0.5-2.8-0.1
Incentive salience index mean3.23.85.72.12.42.32.12.22.02.0-2.11.32.12.0-2.0-0.5-1.6
Condit. Reinf. lever presses0.40.50.91.00.80.90.70.70.70.8-0.80.50.60.7-0.5-0.4-0.3
Condit. Reinf. active minus inactive responses4.05.012.23.52.42.01.91.53.21.6-1.70.52.62.6-2.60.5-2.3
Condit. Reinf. active-inactive response ratio3.53.67.12.72.11.71.41.32.71.3-1.40.02.42.4-2.40.9-2.1
Condit. Reinf. active responses2.73.811.03.32.11.81.81.32.81.5-1.60.82.12.0-2.00.1-1.8
Condit. Reinf. inactive responses0.10.10.50.6-0.1-0.00.2-0.20.0-0.00.10.4-0.4-0.40.5-0.70.5
Condit. Reinf. lever presses1.01.45.92.41.20.90.90.61.90.7-0.80.41.11.1-1.1-0.1-1.0
Condit. Reinf. lever reinforcers received1.82.58.83.01.61.31.30.82.51.0-1.10.41.71.7-1.60.3-1.5
Conditioned reinforcement - actives0.80.81.60.91.10.50.50.61.20.5-0.5-0.31.31.2-1.10.8-0.9
Conditioned reinforcement - inactives0.50.51.20.71.00.60.60.60.80.4-0.50.11.01.0-1.10.3-0.5
Conditioned locomotion0.00.00.10.30.2-0.00.2-0.00.20.2-0.2-0.00.10.1-0.10.10.1
Patch foraging indifference point 0 sec0.20.31.3-0.30.20.40.40.6-0.50.3-0.21.1-0.2-0.20.3-0.90.4
Patch foraging indifference point AUC0.91.03.81.00.60.20.2-0.11.30.1-0.3-1.21.01.3-1.02.0-1.3
Delay disc. indifference point, 0s delay0.20.31.30.1-0.30.1-0.5-0.0-0.4-0.20.30.6-0.6-0.60.6-1.20.4
Delay disc. indifference point, 16s delay0.10.10.2-0.20.40.40.00.50.1-0.00.0-0.00.40.4-0.30.1-0.4
Delay disc. indifference point, 2s delay0.50.50.80.90.90.90.60.80.90.6-0.70.40.70.7-0.60.0-0.9
Delay disc. indifference point, 24s delay0.80.73.4-0.2-0.4-0.7-0.9-0.90.2-0.90.8-1.70.10.1-0.11.8-0.4
Delay disc. indifference point, 4s delay1.01.14.5-0.1-0.6-0.9-1.3-1.10.3-1.21.1-2.0-0.1-0.10.02.1-0.4
Delay disc. indifference point, 8s delay0.60.62.2-0.6-0.4-0.7-1.0-0.7-0.1-1.00.9-1.50.10.1-0.21.4-0.3
Indifference point function ln k0.50.72.50.30.60.90.91.00.01.1-1.01.50.20.1-0.1-1.60.2
Indifference point function log k0.50.72.50.30.60.90.91.00.01.1-1.01.50.20.1-0.1-1.60.2
Patch foraging total patch changes 0 sec0.10.20.5-0.6-0.10.10.20.3-0.6-0.00.10.7-0.3-0.40.4-0.50.5
Patch foraging total patch changes 12 sec0.70.91.70.81.11.11.01.01.00.7-0.70.41.21.3-1.10.7-1.1
Patch foraging total patch changes 18 sec0.60.81.50.41.01.01.11.20.51.2-1.20.90.60.8-0.6-0.4-0.5
Patch foraging total patch changes 24 sec0.81.01.71.31.01.11.31.10.91.3-1.31.20.60.7-0.5-0.6-0.5
Patch foraging total patch changes 6 sec0.20.30.9-1.0-0.5-0.5-0.4-0.4-0.6-0.50.5-0.5-0.4-0.30.40.80.2
Patch foraging time to switch 0 sec1.11.73.8-1.9-1.4-1.1-1.1-0.9-1.9-1.11.2-0.1-1.4-1.61.3-0.81.4
Patch foraging water rate 0 sec2.13.37.22.72.22.02.01.82.11.9-1.91.51.61.7-1.6-0.7-1.2
Patch foraging water rate 12 sec2.33.65.92.22.12.12.22.21.72.4-2.42.21.41.3-1.3-1.3-0.9
Patch foraging water rate 18 sec4.25.79.33.02.72.62.72.52.52.8-2.72.32.01.9-2.0-1.2-1.5
Patch foraging water rate 24 sec1.82.55.22.31.81.71.81.61.71.7-1.71.61.31.2-1.3-1.1-0.9
Patch foraging water rate 6 sec3.65.28.42.92.52.42.82.42.12.8-2.72.71.61.5-1.6-1.9-1.0
Seeking ratio, delayed vs. immediate footshock0.20.20.80.20.40.50.80.60.20.7-0.70.90.20.2-0.2-0.3-0.2
Distance traveled before self-admin2.62.76.31.31.62.21.62.10.72.0-1.92.50.80.8-0.8-2.3-0.4
Distance traveled after self-admin2.22.43.81.41.71.91.82.01.11.7-1.61.91.31.2-1.3-1.7-0.9
Extensor digitorum longus weight0.20.72.00.80.90.91.01.10.50.9-0.81.40.60.5-0.6-1.0-0.1
Bone: elastic displacement0.00.00.10.30.1-0.00.40.10.20.4-0.40.20.00.0-0.1-0.3-0.0
Bone: elastic work0.60.82.41.50.80.71.10.71.11.0-0.90.70.50.6-0.6-0.9-0.5
Bone: endosteal estimation0.51.12.21.31.10.70.70.61.50.6-0.7-0.31.31.3-1.30.8-1.1
Bone: endosteal perimeter0.61.33.11.61.10.80.50.41.80.2-0.3-0.41.41.5-1.41.4-1.4
Epididymis fat weight7.116.522.1-4.1-4.7-4.5-4.5-4.5-4.0-4.64.7-3.3-4.0-4.03.91.53.3
Delta time in closed arm before/after self-admin0.40.41.4-0.2-0.6-0.8-0.7-0.8-0.0-0.70.7-1.2-0.2-0.20.21.10.0
Delta time in open arm before/after self-admin1.21.13.00.61.01.41.11.40.31.3-1.21.70.40.4-0.4-1.6-0.2
Diff in mean of infusions in LGA sessions11.512.718.3-4.3-3.9-4.1-4.1-3.8-3.3-4.24.2-4.0-2.8-2.72.82.81.9
Delay discount exponential model param0.60.62.10.50.40.61.10.70.01.0-1.01.50.10.10.0-1.40.3
Extinction: sum of active levers before priming1.81.84.6-1.0-1.2-0.5-0.0-0.4-1.7-0.00.21.4-1.8-1.81.7-2.11.8
Active lever presses in extinction session 60.50.51.3-1.1-0.7-0.5-0.4-0.3-1.0-0.80.80.0-0.7-0.70.6-0.30.5
Bone: final force2.23.54.92.22.22.02.22.12.02.0-2.01.51.71.9-1.7-1.2-1.3
Bone: final moment2.23.65.12.12.32.12.22.21.92.1-2.11.61.71.9-1.7-1.3-1.2
Food consumed during 24 hour testing period0.40.40.70.90.70.60.60.60.80.8-0.80.40.60.6-0.60.4-0.6
Glucose0.60.81.70.71.10.80.60.81.10.5-0.6-0.11.31.2-1.30.9-1.2
Heart weight0.10.20.70.10.20.50.50.4-0.00.4-0.40.8-0.10.10.1-0.80.0
Delay discount hyperbolic model param0.40.51.70.30.30.50.90.6-0.10.9-0.81.30.00.00.0-1.30.3
Intermittent access intake day 1-15 change3.33.25.12.01.92.02.22.11.42.1-2.02.31.21.1-1.3-1.9-0.8
Intermittent access intake escalation3.53.55.41.92.02.12.32.21.42.3-2.22.31.31.3-1.4-2.0-0.7
Intermittent access intake escalation 22.22.24.41.51.51.91.71.81.01.7-1.62.10.80.9-0.9-1.9-0.5
Intermitt. access day 1 inactive lever presses0.40.41.10.1-0.7-0.8-0.3-0.9-0.4-0.20.2-0.1-0.8-0.90.9-0.41.1
Intermitt. access day 15 inactive lever presses0.00.00.10.4-0.0-0.30.1-0.10.20.1-0.10.0-0.2-0.10.1-0.20.1
Intermitt. access escalation Index1.91.73.31.01.30.70.80.81.60.6-0.8-0.51.81.7-1.81.4-1.8
Intermittent access day 1 total infusions0.30.41.6-1.3-0.4-0.7-0.4-0.1-0.9-0.30.3-0.2-0.6-0.60.80.00.5
Intermittent access day 15 total infusions1.01.12.10.61.21.01.41.40.51.4-1.41.40.60.6-0.5-1.2-0.3
Intermittent access terminal intake (last 3 days)1.11.22.21.01.41.11.31.50.91.3-1.31.30.90.7-0.8-0.9-0.6
Intermittent access total infusions0.50.51.40.20.90.71.01.20.40.9-0.90.90.50.5-0.4-0.5-0.5
Intermittent access day 1 locomotion1.31.43.0-1.5-1.3-1.1-0.7-0.8-1.6-0.50.50.1-1.5-1.61.7-0.61.3
Intermittent access day 15 total locomotion0.70.82.90.60.40.61.00.7-0.01.3-1.21.6-0.3-0.30.2-1.70.6
Intermittent access total locomotion0.30.31.0-0.1-0.4-0.30.5-0.0-0.50.5-0.40.8-0.7-0.70.8-1.00.7
Intermittent access standard deviation2.12.27.50.31.01.52.01.8-0.21.7-1.62.70.00.0-0.0-2.70.3
Left kidney weight0.61.86.82.61.01.21.50.81.71.6-1.61.50.70.7-0.7-0.9-0.7
Right kidney weight0.92.48.12.81.21.51.71.11.81.8-1.81.90.70.9-0.7-1.2-0.8
Cocaine induced anxiety0.40.51.9-0.2-0.5-1.1-0.6-0.90.1-0.50.4-1.30.1-0.10.11.4-0.2
Post-drug Anxiety0.40.41.2-0.3-0.6-1.0-0.5-0.8-0.1-0.60.5-1.1-0.2-0.30.41.1-0.1
Baseline Anxiety0.10.20.7-0.00.20.60.30.5-0.10.3-0.20.8-0.1-0.00.0-0.80.0
Tail length1.85.57.72.42.72.42.42.22.72.3-2.41.02.72.7-2.80.3-2.3
Length with tail0.72.54.82.21.71.81.71.61.81.8-1.81.61.21.3-1.3-0.8-1.1
Length without tail0.20.51.81.20.40.70.60.60.50.6-0.61.4-0.1-0.10.1-1.10.2
Times rat made contact with spout3.64.26.0-1.8-2.4-2.4-2.3-2.4-1.9-2.12.1-1.8-2.1-2.12.11.21.5
Lifetime Intake0.60.71.8-0.01.10.81.11.40.21.1-1.01.00.60.6-0.4-0.7-0.3
Liver weight, left0.20.31.10.1-0.4-0.3-0.1-0.3-0.4-0.00.10.5-0.7-0.70.7-1.00.8
Liver weight, right0.30.51.20.3-0.7-0.5-0.1-0.5-0.5-0.10.20.7-1.0-1.01.0-1.01.1
Locomotor activity2.03.26.32.21.82.12.32.01.42.0-1.92.51.01.0-1.0-1.9-0.7
Locomotor testing distance4.57.513.63.12.83.33.43.12.13.2-3.13.71.81.8-1.7-2.8-1.1
Locomotor testing rearing4.97.614.63.12.73.03.53.02.03.3-3.13.81.61.5-1.6-3.4-0.9
Locomotion in novel chamber0.70.81.7-1.0-1.2-1.3-0.8-1.2-0.8-0.50.5-0.9-0.9-0.90.90.60.6
Locomotion in novel chamber post-restriction0.50.61.10.40.90.91.01.00.51.0-1.00.90.70.6-0.6-0.7-0.5
Fecal boli incidents, locomotor time 10.10.10.4-0.30.30.5-0.10.6-0.20.1-0.00.50.10.00.0-0.60.1
Change in fecal boli incidents, locomotor task0.10.11.00.3-0.10.0-0.0-0.0-0.10.2-0.10.5-0.3-0.20.3-1.00.4
Time >=10cm from walls, locomotor time 10.50.51.70.70.50.70.70.60.20.8-0.71.30.10.1-0.0-1.30.1
Bouts of movement, locomotor time 11.51.63.8-1.9-1.4-1.3-1.2-1.2-1.6-1.41.4-0.9-1.3-1.31.10.50.8
Total resting periods, locomotor time 11.21.33.2-1.8-1.2-1.2-1.1-1.1-1.4-1.31.3-1.0-1.1-1.10.90.60.7
Rest time, locomotor task time 11.21.33.1-1.8-1.3-1.3-1.0-1.1-1.3-1.11.1-1.1-1.1-1.10.91.00.6
Distance moved, locomotor task time 12.62.95.92.41.71.81.91.61.72.1-2.02.01.21.2-1.0-1.6-0.8
Vertical activity count, locomotor time 10.50.51.00.90.70.80.70.70.50.8-0.71.00.40.3-0.3-1.0-0.3
Time >=10cm from walls, locomotor time 20.60.62.20.3-0.6-0.20.1-0.4-0.50.1-0.01.0-1.0-1.11.0-1.51.0
Bouts of movement, locomotor time 20.70.82.2-1.5-1.0-0.7-0.6-0.6-1.3-0.90.9-0.2-1.0-0.91.0-0.10.8
Total resting periods, locomotor time 20.91.02.8-1.7-1.1-0.9-0.8-0.7-1.4-1.11.1-0.4-1.0-0.91.0-0.00.8
Rest time, locomotor task time 20.30.31.6-1.3-0.3-0.5-0.4-0.2-0.6-0.60.6-0.90.00.1-0.00.7-0.1
Distance moved, locomotor task time 21.31.54.72.20.81.01.30.71.11.6-1.51.70.30.2-0.2-1.6-0.1
Vertical activity count, locomotor time 20.20.31.20.2-0.20.10.2-0.0-0.40.5-0.40.9-0.4-0.50.5-1.10.5
Light reinforcement 10.61.12.51.31.10.90.80.61.60.6-0.7-0.11.21.3-1.31.0-1.4
Light reinforcement 21.11.43.41.61.10.70.50.41.90.4-0.5-0.71.61.5-1.51.2-1.5
Bone: marrow area0.51.12.21.31.10.80.70.61.50.7-0.7-0.31.31.4-1.30.8-1.1
Bone: maximum diameter0.50.91.71.31.01.00.50.71.30.5-0.50.31.11.2-1.20.6-1.0
Bone: maximum force2.23.85.32.22.32.32.22.31.92.1-2.11.91.71.8-1.6-1.5-1.1
Bone: maximum moment2.34.05.72.22.32.32.32.41.82.2-2.12.11.61.7-1.6-1.7-1.1
Mean time between licks in bursts0.10.10.20.2-0.4-0.3-0.4-0.5-0.1-0.40.4-0.0-0.3-0.40.3-0.00.3
Mean num. licks in bursts1.11.33.2-1.2-1.0-1.4-1.2-1.1-0.7-1.41.4-1.7-0.6-0.50.61.80.2
Cd content in liver1.01.12.1-0.8-1.2-1.5-1.0-1.0-1.0-1.01.1-0.4-1.3-1.31.3-0.41.1
Co content in liver0.30.40.90.70.60.10.50.30.90.3-0.4-0.30.80.8-0.60.9-0.9
Cu content in liver0.81.01.41.11.10.81.20.91.11.1-1.10.61.11.0-1.0-0.4-0.8
Fe content in liver0.10.10.5-0.4-0.3-0.5-0.4-0.3-0.2-0.30.3-0.7-0.1-0.10.10.60.0
K content in liver0.70.61.51.20.80.10.50.31.20.4-0.5-0.31.11.0-1.20.6-0.7
Mg content in liver0.60.61.51.20.70.10.40.11.20.2-0.3-0.41.00.9-1.10.8-0.7
Mn content in liver5.66.39.53.13.02.52.42.33.12.3-2.41.42.92.8-3.00.2-2.2
Na content in liver2.42.54.52.11.71.81.81.51.61.8-1.81.71.41.4-1.5-0.4-0.9
Rb content in liver0.30.41.41.20.5-0.00.40.11.00.3-0.4-0.20.70.7-0.80.5-0.5
Se content in liver1.82.24.0-1.5-1.7-1.4-1.0-1.2-1.9-0.80.90.1-1.9-2.02.0-0.91.8
Sr content in liver0.90.82.50.50.71.20.81.10.31.0-0.91.60.40.4-0.4-1.5-0.3
Zn content in liver0.91.01.6-0.9-1.1-1.3-1.0-1.1-1.0-1.11.1-0.7-1.0-1.00.9-0.00.9
Bone: minimum diameter0.40.71.41.20.91.01.00.90.90.8-0.80.90.70.7-0.7-0.6-0.6
Time in familiar zone, hab. session 10.30.31.4-0.0-0.4-0.8-0.4-0.70.2-0.50.4-1.20.00.1-0.11.1-0.2
Time in novel zone, hab. session 10.90.92.0-0.7-0.8-0.3-0.6-0.3-1.2-0.50.60.9-1.3-1.31.4-1.21.2
Total zone transitions, hab. session 11.11.55.02.21.11.11.30.81.51.5-1.51.20.70.7-0.8-0.9-0.6
Total locomotion distance, hab. session 11.92.77.02.61.81.61.61.42.11.7-1.81.11.51.5-1.6-0.3-1.3
Locomotion velocity, hab. session 11.31.94.42.11.51.41.41.21.71.4-1.40.91.31.2-1.4-0.4-1.1
Time in familiar zone, hab. session 21.81.93.3-1.0-1.6-1.6-1.6-1.8-0.8-1.71.6-1.7-1.0-1.00.91.50.4
Time in novel zone, hab. session 20.90.93.00.40.91.11.01.30.01.2-1.11.60.20.2-0.2-1.70.2
Total zone transitions, hab. session 20.50.72.21.50.70.80.90.60.90.9-0.91.00.50.4-0.5-0.9-0.3
Total locomotion distance, hab. session 20.71.01.51.21.11.11.00.91.20.9-0.90.61.11.0-1.2-0.2-0.9
Locomotion velocity, hab. session 20.60.81.61.31.00.90.90.81.10.8-0.80.51.00.9-1.1-0.2-0.8
Novel to familiar place preference ratio1.51.63.4-0.5-1.5-1.2-1.0-1.2-1.2-0.80.90.2-1.8-1.81.8-1.01.5
Novelty place preference1.92.04.1-0.7-1.6-1.2-1.1-1.2-1.5-0.80.90.3-2.0-2.02.0-1.21.7
Time in novel zone, NPP test2.42.45.0-0.9-1.7-1.2-1.1-1.1-1.8-0.80.90.7-2.2-2.22.2-1.72.0
Total zone transitions, NPP test0.10.10.60.7-0.2-0.2-0.1-0.50.4-0.10.0-0.2-0.1-0.20.00.1-0.1
Total locomotion distance, NPP test0.71.02.31.51.00.80.70.51.50.6-0.70.01.21.1-1.20.6-1.2
Locomotion velocity, NPP test1.11.53.61.81.20.90.80.61.90.6-0.7-0.31.51.5-1.61.1-1.5
Intraocular pressure1.11.53.50.91.31.51.51.50.61.4-1.31.90.70.7-0.9-1.5-0.2
Delta distance traveled before/after self-admin0.30.31.1-0.2-0.2-0.6-0.2-0.50.2-0.50.5-1.00.40.2-0.41.1-0.4
Delta ambulatory time before/after self-admin0.80.81.70.91.00.50.80.61.20.6-0.6-0.21.31.2-1.30.6-1.2
Parametrial fat weight4.58.712.3-2.8-3.5-3.3-3.4-3.3-3.0-3.23.2-2.2-3.1-3.03.10.52.5
Pavlov. Cond. lever latency0.40.40.8-0.8-0.8-0.6-0.7-0.6-0.9-0.40.4-0.0-0.8-0.90.7-0.30.6
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.3-0.3-0.4-0.2-0.4-0.20.2-0.2-0.3-0.30.4-0.20.3
Pavlov. Cond. change in total contacts0.80.91.60.81.31.10.91.11.00.7-0.70.31.21.2-1.1-0.1-0.8
Pavlov. Cond. index score0.20.30.60.80.60.60.40.50.60.4-0.40.30.50.6-0.4-0.2-0.4
Pavlov. Cond. latency score0.20.30.60.80.70.60.40.50.80.4-0.40.10.70.7-0.60.0-0.5
Pavlov. Cond. lever contacts0.60.71.11.01.11.00.90.81.00.7-0.70.41.01.0-0.90.0-0.7
Pavlov. Cond. magazine entry number0.20.30.5-0.4-0.6-0.6-0.4-0.6-0.5-0.40.4-0.1-0.7-0.70.6-0.00.5
Pavlov. Cond. intertrial magazine entries1.21.52.41.21.51.31.21.31.31.2-1.30.51.41.4-1.30.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.70.60.60.40.50.60.3-0.30.30.50.5-0.4-0.2-0.3
Pavlov. Cond. response bias0.30.40.70.40.80.70.50.80.60.5-0.50.10.80.8-0.70.0-0.6
Pavlov. Cond. lever latency0.30.52.4-1.1-0.2-0.5-0.5-0.3-0.3-0.60.5-1.20.30.2-0.21.5-0.3
Pavlov. Cond. magazine entry latency2.93.45.0-1.8-2.1-2.2-2.1-2.1-1.7-2.02.1-1.8-1.7-1.71.70.61.3
Pavlov. Cond. change in total contacts0.10.10.40.5-0.2-0.1-0.1-0.20.0-0.10.20.3-0.4-0.40.4-0.70.4
Pavlov. Cond. index score1.01.31.9-0.6-1.4-1.3-1.3-1.3-1.0-1.21.2-0.7-1.3-1.31.3-0.41.1
Pavlov. Cond. latency score1.21.52.2-0.8-1.5-1.5-1.5-1.5-1.0-1.41.4-1.0-1.3-1.31.3-0.11.0
Pavlov. Cond. lever contacts0.20.21.21.00.00.20.20.00.30.2-0.10.7-0.3-0.30.3-1.10.3
Pavlov. Cond. magazine entry number2.83.45.21.52.12.32.32.21.52.1-2.12.01.71.7-1.7-0.8-1.2
Pavlov. Cond. intertrial magazine entries4.55.88.72.32.82.42.52.32.82.3-2.40.82.82.9-2.80.6-2.5
Pavlov. Cond. lever-magazine prob. diff.1.01.31.9-0.6-1.3-1.4-1.3-1.3-0.9-1.21.2-0.8-1.2-1.31.3-0.31.0
Pavlov. Cond. response bias0.50.61.50.2-0.8-0.6-0.5-0.7-0.5-0.40.50.2-1.1-1.11.1-1.21.0
Time in closed arm before self-admin0.10.10.60.20.2-0.10.1-0.10.50.1-0.1-0.50.30.4-0.30.8-0.3
Time in closed arm after self-admin0.50.51.90.80.4-0.10.1-0.21.00.1-0.2-0.90.70.8-0.81.4-0.8
Time in open arm before self-admin2.22.43.7-1.9-1.7-1.8-1.8-1.7-1.4-1.91.8-1.9-0.9-1.10.91.40.6
Time in open arm after self-admin0.80.92.2-1.4-0.7-0.2-0.60.0-1.5-0.50.60.7-1.0-1.01.1-1.31.0
Bone: periosteal estimation1.12.33.92.01.81.71.51.51.81.4-1.51.11.61.7-1.6-0.3-1.2
Bone: periosteal perimeter1.01.63.61.91.41.51.11.11.70.8-0.90.91.31.4-1.30.2-1.2
Bone: post-yield work0.71.02.30.51.31.41.11.50.51.0-0.91.30.80.8-0.8-1.1-0.3
Progressive ratio test 1 active lever presses1.01.01.50.81.21.11.21.20.91.1-1.10.91.01.1-1.1-0.3-0.8
Progressive ratio test 1 breakpoint1.71.82.81.21.71.41.51.61.31.4-1.41.11.41.2-1.4-0.4-1.1
Progressive ratio test 1 inactive lever presses0.10.10.30.2-0.4-0.5-0.1-0.5-0.2-0.20.20.1-0.5-0.50.4-0.40.6
Progressive ratio test 2 active lever presses0.30.31.30.10.5-0.2-0.10.10.6-0.1-0.0-0.80.80.7-0.71.1-0.7
Progressive ratio test 2 breakpoint0.50.61.30.50.80.20.50.51.00.3-0.4-0.50.91.1-0.91.1-1.1
Progressive ratio test 2 inactive lever presses0.50.61.10.51.00.50.90.90.80.8-0.80.21.01.0-0.90.1-0.8
Incentive Sensitization - Responses1.61.65.20.71.0-0.0-0.10.11.5-0.20.1-1.61.71.7-1.72.3-1.6
Incentive Sensitization - Breakpoint1.41.54.50.70.9-0.0-0.10.11.5-0.20.0-1.51.61.6-1.62.1-1.5
Sum of active levers in priming session hrs 5-63.53.46.4-2.5-2.1-1.6-1.3-1.5-2.5-1.51.6-0.3-2.2-2.22.3-0.61.8
Progressive ratio0.20.30.5-0.60.50.50.50.7-0.40.3-0.30.70.40.2-0.6-0.7-0.2
Food seeking constrained by brief footshock0.20.20.9-0.5-0.1-0.5-0.2-0.3-0.1-0.50.5-0.90.10.2-0.20.9-0.2
Seeking ratio, punishment vs. effort0.10.20.60.2-0.3-0.6-0.3-0.50.2-0.30.3-0.8-0.4-0.10.50.70.2
Retroperitoneal fat weight3.712.118.2-2.4-4.2-4.1-3.9-4.3-2.9-3.83.9-2.9-3.8-3.63.71.02.7
Reaction time number correct0.81.17.80.7-0.30.40.40.1-0.40.6-0.41.6-0.9-0.90.9-2.81.1
Reaction time mean minus median1.21.72.9-1.7-1.5-1.7-1.4-1.4-1.5-1.01.0-1.3-1.1-1.31.00.41.0
Reaction time mean minus median AUC1.82.34.0-1.9-1.8-2.0-1.6-1.8-1.6-1.41.4-1.8-1.3-1.31.30.91.0
Reaction time num false alarms1.62.24.32.11.51.71.71.31.71.4-1.41.31.41.4-1.4-0.4-1.2
Reaction time num false alarms AUC1.82.53.71.91.71.91.81.61.61.6-1.61.61.51.5-1.4-0.8-1.1
Reaction time trials correct on left0.81.17.80.7-0.30.40.40.1-0.40.6-0.41.6-0.9-0.90.9-2.81.1
Reaction time trials on left0.81.17.70.7-0.30.30.30.1-0.50.6-0.41.6-0.9-0.90.9-2.81.1
Reaction time mean1.11.63.9-1.3-1.1-1.6-1.6-1.3-0.9-1.51.4-2.0-0.4-0.70.41.40.4
Reaction time mean AUC1.62.15.1-1.5-1.3-1.8-1.9-1.5-1.1-1.81.8-2.3-0.5-0.80.51.60.5
Median of all reaction times0.71.03.0-0.9-0.7-1.2-1.2-0.9-0.5-1.31.2-1.7-0.1-0.3-0.01.40.1
Reaction time omissions1.62.23.9-1.4-1.6-1.8-1.9-1.7-1.2-2.02.0-1.7-1.0-1.20.90.70.9
Reaction time false alarm rate1.31.93.11.41.61.31.31.21.70.9-1.00.31.81.8-1.70.9-1.6
Reaction time premature initiation rate0.20.30.6-0.4-0.7-0.6-0.5-0.6-0.5-0.60.5-0.3-0.6-0.60.80.70.3
Reaction time premature initiations0.30.41.10.0-0.6-0.2-0.2-0.4-0.5-0.10.20.6-0.9-0.91.1-0.80.8
Std. dev. reaction times1.21.72.8-1.6-1.5-1.7-1.5-1.4-1.4-1.31.2-1.5-1.0-1.20.90.80.9
Reaction time trials completed0.81.17.70.7-0.30.30.30.1-0.50.6-0.41.6-0.9-0.90.9-2.81.1
Reaction time trials AUC0.81.17.51.10.20.80.70.5-0.00.9-0.81.8-0.4-0.50.4-2.70.7
Run reversals in cocaine runway, females0.10.10.40.4-0.20.1-0.0-0.00.0-0.00.10.4-0.5-0.20.6-0.60.4
Run reversals in cocaine runway, males1.31.25.5-0.5-0.4-0.9-1.0-0.90.2-1.21.1-2.30.40.5-0.32.3-0.6
Latency to leave start box in cocaine runway0.80.93.80.1-0.5-0.9-1.0-1.20.4-1.00.9-2.00.20.2-0.31.8-0.3
Latency to leave start box in cocaine runway, F0.80.93.50.2-0.6-0.9-1.1-1.20.3-1.11.1-1.90.10.1-0.21.5-0.1
Latency to leave start box in cocaine runway, M0.10.10.6-0.2-0.0-0.2-0.1-0.20.10.0-0.1-0.60.20.3-0.20.8-0.3
Std. dev. time between licks in bursts1.21.52.41.41.21.31.51.31.11.4-1.41.41.00.9-1.0-1.0-0.6
Total sessions with >9 infusions0.60.72.3-1.5-0.4-0.10.20.2-1.5-0.00.10.9-0.8-0.80.8-1.11.0
Short access day 1 total inactive lever presses0.00.00.20.5-0.1-0.10.2-0.20.2-0.20.20.1-0.2-0.10.20.1-0.1
Short access day 10 total inactive lever presses0.20.20.70.90.1-0.00.50.10.40.6-0.50.6-0.3-0.30.1-0.80.2
Short access day 1 total infusions0.70.71.60.61.00.81.31.10.71.0-1.00.90.70.8-0.6-0.4-0.7
Short access day 10 total infusions1.61.73.30.71.51.51.81.80.71.7-1.71.70.91.0-0.7-1.2-0.6
Short access total infusions0.60.71.9-0.40.90.81.21.4-0.10.9-0.91.20.30.5-0.3-0.9-0.2
Short access day 1 locomotion0.40.41.80.1-0.30.00.60.1-0.50.4-0.31.1-0.7-0.60.6-1.30.7
Short access day 10 total locomotion0.10.10.5-0.7-0.4-0.5-0.1-0.4-0.5-0.10.1-0.3-0.3-0.30.10.20.3
Short access total locomotion0.50.51.4-1.1-0.6-0.20.1-0.1-1.20.1-0.00.7-0.9-0.80.8-1.00.9
One hour access (0.3 mA shock)0.10.10.40.60.50.10.10.30.40.2-0.20.20.20.2-0.1-0.40.0
Compulsive drug intake3.43.45.1-1.8-2.3-2.2-1.9-2.1-1.7-2.02.0-1.6-1.9-1.91.80.71.4
One hour access (shock baseline)1.11.32.41.51.51.21.01.21.41.1-1.10.71.31.2-1.0-0.2-0.9
Social response proportion1.71.85.0-1.4-1.1-1.5-1.7-1.5-0.6-1.71.6-2.2-0.3-0.50.32.00.0
Social responses1.21.63.11.41.41.10.80.81.80.7-0.8-0.21.61.6-1.71.1-1.6
Social time0.30.40.7-0.4-0.6-0.6-0.9-0.8-0.4-0.80.8-0.7-0.4-0.40.40.40.4
Soleus weight0.10.31.41.20.40.30.70.20.70.5-0.50.50.30.3-0.3-0.3-0.1
Bone: stiffness2.23.55.31.92.22.22.22.31.72.0-2.01.91.61.7-1.6-1.1-1.2
Tibialis anterior weight0.10.40.8-0.9-0.6-0.8-0.7-0.5-0.8-0.80.8-0.5-0.5-0.50.60.10.8
Time to tail flick, vehicle, before self-admin3.73.76.0-1.8-2.4-2.4-1.8-2.4-1.8-1.71.7-1.7-2.2-1.92.20.71.4
Time to tail flick, vehicle, after self-admin2.32.43.7-1.9-1.9-1.7-1.7-1.6-1.8-1.41.5-1.0-1.7-1.71.7-0.11.2
Time to tail flick, test, before self-admin0.70.72.41.20.50.00.5-0.21.4-0.1-0.0-0.80.80.9-0.71.6-0.9
Time to tail flick, test, after self-admin0.20.20.60.40.50.60.50.60.20.4-0.40.70.10.3-0.1-0.7-0.0
Delta time to tail flick, vehicle, before/after SA0.90.91.40.71.11.10.91.20.71.0-1.00.81.10.8-1.1-0.4-0.8
Delta time to tail flick, test, before/after SA0.50.51.1-0.9-0.5-0.2-0.6-0.0-1.0-0.30.40.4-0.8-0.80.8-1.10.7
Tibia length5.816.427.45.24.93.93.63.75.23.7-3.91.44.64.7-4.60.3-3.7
Ambulatory time before self-admin2.42.58.11.01.32.01.72.00.31.7-1.62.80.40.3-0.4-2.80.1
Ambulatory time after self-admin1.11.21.91.01.31.31.11.40.91.1-1.01.11.11.0-1.1-1.0-0.8
Bone: tissue strength1.51.42.31.51.21.21.41.31.01.5-1.41.50.70.8-0.6-1.5-0.4
Total heroin consumption2.53.06.8-2.3-2.0-1.3-1.1-1.0-2.6-0.70.80.4-2.1-2.32.2-1.41.8
Bone: trabecular number0.40.61.00.21.00.81.01.00.50.8-0.80.10.90.9-0.90.1-0.6
Bone: trabecular spacing1.11.42.4-0.6-1.5-1.4-1.4-1.6-0.9-1.31.3-0.9-1.3-1.31.20.40.9
Bone: trabecular thickness1.41.63.20.51.61.51.41.80.81.5-1.51.01.31.3-1.3-0.7-0.9
Bone: trabecular tissue density0.10.10.50.60.00.3-0.2-0.00.10.00.00.5-0.2-0.20.1-0.70.3
Water consumed over 24 hours0.10.10.30.20.30.30.30.30.20.5-0.50.20.20.2-0.2-0.2-0.1
Number of responses in last shaping day1.81.93.31.81.51.21.51.41.81.5-1.50.81.11.4-1.20.2-1.5