Slc46a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Slc46a3	0.61	0.13	0.0e+00	0.37	0.34	0.35	0.36	1.9e-42	2.2e-39	4.8e-40	5.2e-41
2	BLA	alternative TSS	NM_001024968.1	0.1	0.07	9.2e-03	0	0.04	0.01	0.01	2.2e-01	2.0e-03	9.2e-02	6.1e-02
3	BLA	alternative TSS	XM_006248833.4	0.11	0.07	8.5e-03	0	0.05	0.01	0.01	2.2e-01	1.7e-03	8.8e-02	5.2e-02
4	Adipose	mRNA stability	Slc46a3	0.29	0.13	3.3e-15	0.12	0.1	0.11	0.11	5.5e-13	1.1e-11	8.5e-12	1.2e-12
5	NAcc	mRNA stability	Slc46a3	0.08	0.05	2.5e-03	0	0.01	0.01	0	1.6e-01	9.3e-03	2.2e-02	1.8e-01
6	Brain	mRNA stability	Slc46a3	0.19	0.1	9.6e-04	0.03	0.04	0.03	0.03	1.4e-03	1.2e-04	1.2e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.0	1.7	3.1	1.5	1.8	-1.7	1.1	0.5	0.8
Area under the delay curve	0.8	0.8	2.8	-1.7	-0.8	0.8	-1.0	-0.1	0.4
BMI with tail	0.4	1.3	2.7	1.6	1.1	-1.1	1.5	-0.0	0.5
BMI without tail	0.4	0.8	1.6	-1.0	0.5	-0.5	-1.0	1.3	0.8
Body weight	0.6	2.5	6.2	-2.5	-1.3	1.2	-1.8	-1.0	1.2
Weight adjusted by age	1.8	2.0	5.2	1.0	-1.6	1.6	0.7	-2.3	-0.3
Bone surface	1.0	1.7	3.3	1.0	1.7	-1.7	-0.0	0.6	1.8
Bone volume	1.4	2.4	3.8	1.7	1.9	-1.9	0.6	0.5	1.8
Breakpoint value in progressive ratio session	1.1	1.2	5.1	-0.3	0.6	-0.6	-1.1	0.3	2.3
Number of licking bursts	0.2	0.3	0.6	-0.8	-0.6	0.6	-0.3	-0.0	-0.3
Context. condit. distance diff. score	0.2	0.3	0.5	-0.6	-0.6	0.6	-0.7	-0.1	0.2
Locomotion velocity, session 1	1.6	1.8	2.8	-1.7	-1.7	1.6	-0.9	-1.1	-0.5
Locomotion distance, session 1	0.7	0.9	1.7	-0.6	-1.1	1.1	0.4	-1.3	-0.9
Locomotion velocity, session 2	1.0	1.2	1.6	-1.3	-1.3	1.3	-0.0	-1.0	-1.2
Locomotion distance, session 2	1.2	1.7	2.7	-1.4	-1.6	1.6	-0.2	-1.6	-0.8
Locomotion velocity, session 3	0.9	1.0	2.0	-0.5	-1.4	1.4	-0.3	-1.4	-0.3
Locomotion distance, session 3	0.3	0.3	0.8	-0.9	-0.6	0.6	-0.7	-0.3	-0.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	-0.4	0.4	-0.4	-1.0	0.9	0.7
Stereotopy head waving duration, day 3	0.3	0.3	0.8	0.5	0.5	-0.5	-0.4	0.6	0.9
Locomotion velocity, session 7	0.4	0.4	1.1	-0.6	-0.3	0.3	-0.8	-0.2	1.1
Locomotion distance, session 7	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.1	-0.3	0.4
Stereotopy head waving bouts, day 7	0.6	0.7	2.3	-1.1	-0.4	0.3	-1.5	0.4	0.6
Stereotopy head waving duration, day 7	0.3	0.4	1.1	-0.8	-0.6	0.6	-1.0	0.0	0.1
Locomotion velocity, session 8	2.2	2.7	4.9	-1.7	-2.2	2.2	-0.5	-1.5	-1.0
Locomotion distance, session 8	1.2	1.7	3.0	-1.3	-1.7	1.7	-0.6	-1.4	-0.6
Degree of sensitization distance	0.0	0.0	0.1	0.0	0.0	0.0	0.3	-0.1	0.2
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.1	-0.2	0.2	-0.5	-0.2	0.5
Conditioned locomotion	0.6	0.7	1.5	-0.1	0.8	-0.8	0.6	1.2	-1.2
Cocaine response after cond. corrected	0.6	0.6	1.2	0.4	1.1	-1.1	0.5	1.0	-0.4
Cocaine response after cond. not corrected	0.6	0.6	1.3	0.1	1.1	-1.1	0.3	1.2	-0.2
Cocaine response before conditioning	0.6	0.7	1.7	-1.3	-0.8	0.8	-1.1	0.0	0.5
Saline control response	1.0	1.4	2.4	-1.6	-1.4	1.3	-1.2	-0.2	-0.8
Bone: connectivity density	0.6	0.9	2.0	0.3	1.4	-1.4	0.2	0.9	0.8
Bone: cortical apparent density	2.5	3.3	6.2	2.0	2.5	-2.5	1.1	1.5	0.4
Bone: cortical area	2.5	3.8	6.3	-0.5	1.9	-2.0	-1.9	2.3	2.5
Bone: cortical porosity	1.2	1.3	2.4	-1.2	-1.5	1.5	-0.3	-1.1	-0.8
Bone: cortical porosity	1.2	1.3	2.3	-1.3	-1.5	1.5	-0.5	-0.9	-0.8
Bone: cortical thickness	3.3	5.4	8.9	0.5	3.0	-3.0	-1.1	2.8	2.3
Bone: cortical thickness	0.4	0.4	0.8	-0.4	0.9	-0.9	-0.3	0.9	0.1
Bone: cortical tissue density	2.6	3.4	6.0	2.2	2.4	-2.4	1.4	1.4	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	0.8	1.0	-1.0	0.2	1.0	0.2
Condit. Reinf. active-inactive response ratio	2.1	2.2	4.8	2.2	1.8	-1.7	1.3	0.8	0.3
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	0.2	-0.2	0.2	0.2	-0.2
Condit. Reinf. inactive responses	0.8	0.9	1.9	-1.4	-1.1	1.1	-0.9	-0.6	0.1
Incentive salience index mean	0.3	0.3	0.6	-0.2	0.4	-0.4	-0.8	0.7	0.7
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.2	0.4	-0.5	-0.9	0.5	1.2
Condit. Reinf. active minus inactive responses	0.9	1.1	3.2	-1.8	-1.0	1.0	-0.8	0.1	-0.8
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.9	-1.7	-1.3	1.2	-0.8	-0.3	-0.6
Condit. Reinf. active responses	1.6	2.2	5.5	-2.3	-1.7	1.7	-1.0	-0.4	-1.0
Condit. Reinf. inactive responses	0.7	0.9	1.9	-1.4	-1.1	1.0	-0.9	-0.3	-0.4
Condit. Reinf. lever presses	0.4	0.6	2.1	-1.5	-0.1	0.1	-0.9	0.8	0.1
Condit. Reinf. lever reinforcers received	1.5	2.2	5.4	-2.3	-1.7	1.6	-1.1	-0.3	-0.9
Conditioned reinforcement - actives	0.3	0.3	0.8	-0.2	-0.5	0.5	-0.9	-0.3	0.5
Conditioned reinforcement - inactives	0.3	0.3	0.7	-0.8	-0.5	0.5	-0.2	-0.1	-0.8
Conditioned locomotion	0.8	1.0	2.0	-0.9	-1.1	1.1	-1.4	-0.5	0.8
Patch foraging indifference point 0 sec	0.1	0.2	0.3	-0.5	-0.5	0.5	0.1	-0.1	-0.6
Patch foraging indifference point AUC	1.2	1.4	2.6	-0.8	-1.5	1.5	0.2	-1.6	-0.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.6	-0.2	0.2	-0.0	-0.2	0.3
Delay disc. indifference point, 16s delay	0.8	0.8	1.4	-0.9	-1.2	1.2	-0.2	-1.0	-0.5
Delay disc. indifference point, 2s delay	0.4	0.5	1.6	-1.3	-0.3	0.3	-0.8	-0.1	0.7
Delay disc. indifference point, 24s delay	1.3	1.3	3.5	0.3	-1.4	1.4	0.5	-1.9	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.5	0.0	-0.0	0.1	-0.0	0.5
Delay disc. indifference point, 8s delay	0.5	0.5	2.0	-1.4	-0.2	0.2	-0.8	0.7	-0.0
Indifference point function ln k	0.8	1.1	2.3	-0.7	0.7	-0.8	-1.5	1.5	0.8
Indifference point function log k	0.8	1.1	2.3	-0.7	0.7	-0.8	-1.5	1.5	0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.6	-0.6	0.5	-0.1	-0.1	-0.5
Patch foraging total patch changes 12 sec	0.4	0.5	1.0	-0.6	-1.0	1.0	-0.3	-0.7	-0.2
Patch foraging total patch changes 18 sec	0.6	0.8	2.8	0.9	0.3	-0.3	1.7	-0.3	-0.9
Patch foraging total patch changes 24 sec	0.9	1.0	2.0	-0.6	-1.4	1.4	0.3	-1.2	-0.7
Patch foraging total patch changes 6 sec	0.5	0.7	1.8	-1.3	-0.8	0.8	-1.0	-0.2	0.4
Patch foraging time to switch 0 sec	0.7	1.1	1.9	1.1	1.4	-1.4	0.8	0.8	0.4
Patch foraging water rate 0 sec	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.4	0.2	0.0
Patch foraging water rate 12 sec	0.9	1.3	2.4	-0.6	1.0	-1.0	-1.4	1.2	1.6
Patch foraging water rate 18 sec	0.6	0.8	1.5	-1.2	-1.0	0.9	-1.2	-0.2	0.3
Patch foraging water rate 24 sec	0.7	1.0	2.0	-0.1	1.2	-1.2	-0.6	1.4	0.8
Patch foraging water rate 6 sec	0.8	1.2	3.4	0.5	1.2	-1.2	-0.2	1.8	0.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.3	-1.2	-0.9	0.9	-0.9	0.1	-0.8
Distance traveled before self-admin	0.9	1.0	2.1	1.1	-0.8	0.9	1.1	-1.5	-0.2
Distance traveled after self-admin	0.1	0.1	0.3	0.1	-0.1	0.1	-0.4	0.1	0.6
Extensor digitorum longus weight	0.1	0.5	2.0	0.1	-0.3	0.3	-0.3	-0.9	1.4
Bone: elastic displacement	1.8	2.0	7.5	-0.1	-0.8	0.8	1.6	-0.9	-2.7
Bone: elastic work	0.9	1.2	2.5	-1.1	-1.1	1.1	0.2	-1.0	-1.6
Bone: endosteal estimation	0.4	0.9	2.1	-1.4	-1.1	1.1	-0.9	-0.2	-0.6
Bone: endosteal perimeter	0.5	1.1	2.7	-1.5	-0.8	0.7	-1.6	0.1	0.7
Epididymis fat weight	0.4	1.0	1.9	0.9	1.3	-1.3	0.4	-0.1	1.4
Delta time in closed arm before/after self-admin	1.4	1.4	4.2	-2.1	-0.9	0.8	-1.6	0.1	0.3
Delta time in open arm before/after self-admin	1.6	1.5	4.0	0.9	-0.5	0.5	2.0	-1.5	-1.2
Diff in mean of infusions in LGA sessions	0.8	0.9	3.7	1.0	0.5	-0.5	-0.3	-0.3	1.9
Delay discount exponential model param	0.6	0.7	2.3	1.5	0.7	-0.6	0.9	0.0	-0.4
Extinction: sum of active levers before priming	1.0	1.0	2.6	0.0	-1.0	1.1	0.9	-1.6	-0.4
Active lever presses in extinction session 6	0.6	0.6	1.2	1.1	-0.2	0.2	1.0	-1.1	0.3
Bone: final force	0.3	0.5	1.4	-1.0	-0.0	-0.0	-1.2	0.7	0.4
Bone: final moment	0.2	0.4	0.9	-0.8	0.2	-0.2	-1.0	0.8	0.3
Food consumed during 24 hour testing period	0.8	0.9	1.5	-0.9	-1.2	1.2	-0.4	-1.2	-0.2
Glucose	1.3	2.0	3.8	-1.1	-1.8	1.8	0.1	-2.0	-0.7
Heart weight	0.8	1.1	4.2	-2.0	-0.4	0.4	-1.0	0.7	-0.9
Delay discount hyperbolic model param	0.6	0.7	2.4	1.5	0.7	-0.6	0.8	0.0	-0.4
Intermittent access intake day 1-15 change	0.8	0.7	2.4	1.2	0.2	-0.2	0.8	0.2	-1.6
Intermittent access intake escalation	0.8	0.8	3.4	0.9	0.2	-0.2	0.6	0.4	-1.8
Intermittent access intake escalation 2	1.8	1.8	6.1	1.0	0.7	-0.7	1.3	1.0	-2.5
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.8	-0.6	-0.9	0.9	-0.3	-0.6	-0.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.1	-0.5	-1.1	1.0	-0.6	-0.9	0.5
Intermitt. access escalation Index	1.1	1.0	2.1	1.5	1.2	-1.2	0.6	0.8	0.3
Intermittent access day 1 total infusions	0.4	0.4	0.7	-0.5	0.4	-0.5	-0.8	0.8	0.8
Intermittent access day 15 total infusions	0.3	0.4	1.0	0.3	0.7	-0.7	-0.5	1.0	0.1
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.8	0.7	-0.7	-0.1	0.6	0.3
Intermittent access total infusions	0.3	0.3	0.5	0.1	0.4	-0.4	-0.7	0.7	0.7
Intermittent access day 1 locomotion	0.3	0.3	0.5	-0.4	0.3	-0.3	-0.7	0.7	0.5
Intermittent access day 15 total locomotion	0.3	0.4	0.6	-0.6	-0.8	0.7	-0.6	-0.5	0.2
Intermittent access total locomotion	0.3	0.3	0.7	-0.4	-0.8	0.8	-0.4	-0.5	-0.2
Intermittent access standard deviation	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	-0.1	0.1
Left kidney weight	1.0	2.9	5.2	-1.6	-2.2	2.2	-0.6	-2.3	-0.1
Right kidney weight	0.5	1.4	2.2	-1.1	-1.1	1.1	-1.5	-1.1	1.2
Cocaine induced anxiety	0.3	0.3	0.6	-0.2	0.8	-0.8	-0.2	0.8	0.1
Post-drug Anxiety	0.5	0.5	1.0	0.4	1.0	-1.0	0.4	0.8	-0.1
Baseline Anxiety	0.8	0.8	1.6	1.0	-0.6	0.6	1.3	-1.2	-0.6
Tail length	2.7	8.2	20.8	-4.6	-2.6	2.5	-3.8	-0.3	0.5
Length with tail	3.7	13.6	30.8	-5.6	-3.9	3.9	-4.1	-1.9	0.3
Length without tail	1.1	2.3	3.1	-1.7	-1.7	1.6	-1.3	-1.8	0.7
Times rat made contact with spout	0.8	1.0	2.9	-1.7	-0.5	0.5	-1.3	-0.2	0.6
Lifetime Intake	0.3	0.3	0.6	-0.1	0.4	-0.4	-0.7	0.6	0.8
Liver weight, left	0.7	1.1	4.2	1.1	0.7	-0.7	-0.5	-0.0	2.1
Liver weight, right	0.9	1.5	4.0	-0.7	-0.4	0.4	-2.0	-0.1	2.0
Locomotor activity	0.4	0.7	1.7	-1.3	-0.2	0.1	-1.3	0.8	0.3
Locomotor testing distance	0.2	0.4	1.2	0.3	0.3	-0.3	0.5	0.7	-1.1
Locomotor testing rearing	0.5	0.8	1.1	0.8	1.0	-1.0	0.8	1.0	-0.6
Locomotion in novel chamber	1.2	1.4	5.4	-2.3	-1.0	0.9	-1.0	-0.0	-0.7
Locomotion in novel chamber post-restriction	0.9	1.1	3.9	-2.0	0.1	-0.1	-1.3	0.8	0.5
Fecal boli incidents, locomotor time 1	5.4	5.9	11.5	-0.1	-3.1	3.1	1.0	-3.4	-1.9
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	-0.2	0.9	-0.9	-0.5	1.3	0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	0.5	-0.5	-0.2	0.2	0.2
Bouts of movement, locomotor time 1	0.3	0.4	0.9	0.2	-0.9	0.9	-0.3	-0.6	-0.0
Total resting periods, locomotor time 1	0.5	0.5	1.1	0.3	-1.0	1.0	-0.2	-0.9	0.0
Rest time, locomotor task time 1	0.4	0.5	0.8	-0.0	-0.9	0.9	0.2	-0.5	-0.9
Distance moved, locomotor task time 1	0.3	0.3	1.4	0.0	0.5	-0.5	-0.1	-0.5	1.2
Vertical activity count, locomotor time 1	1.0	1.0	1.8	0.3	1.4	-1.4	-0.3	1.0	1.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.1	-0.1
Bouts of movement, locomotor time 2	0.9	1.0	2.5	-0.4	0.7	-0.7	-1.1	0.9	1.6
Total resting periods, locomotor time 2	0.5	0.5	1.3	-0.4	0.4	-0.4	-0.9	0.5	1.2
Rest time, locomotor task time 2	0.9	1.0	2.0	-0.9	-1.4	1.4	-0.7	-0.6	-0.6
Distance moved, locomotor task time 2	1.4	1.6	3.5	1.9	1.5	-1.4	0.6	0.2	1.3
Vertical activity count, locomotor time 2	3.4	3.7	6.1	2.5	2.4	-2.4	1.1	1.3	1.0
Light reinforcement 1	1.7	3.1	4.9	0.1	-2.1	2.1	1.4	-1.7	-2.2
Light reinforcement 2	2.0	2.7	4.6	1.0	-1.6	1.6	1.8	-2.1	-1.5
Bone: marrow area	0.4	0.9	2.2	-1.5	-1.1	1.1	-0.8	-0.2	-0.6
Bone: maximum diameter	1.1	1.9	4.1	-0.6	1.1	-1.1	-1.7	1.4	2.0
Bone: maximum force	0.7	1.3	3.2	-1.2	0.4	-0.4	-1.8	0.9	1.4
Bone: maximum moment	0.6	1.1	2.4	-1.0	0.5	-0.6	-1.5	1.0	1.3
Mean time between licks in bursts	1.2	1.7	3.2	1.0	1.7	-1.7	0.2	1.8	0.4
Mean num. licks in bursts	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.3	-0.3	0.6
Cd content in liver	1.3	1.4	4.3	1.2	0.1	-0.0	1.7	0.0	-2.1
Co content in liver	0.8	1.0	1.6	0.3	-0.9	0.9	1.0	-1.3	-1.3
Cu content in liver	0.9	1.1	2.6	1.5	-0.5	0.5	1.2	-1.6	0.1
Fe content in liver	3.3	4.0	8.7	3.0	2.3	-2.3	1.3	1.0	1.4
K content in liver	0.2	0.2	0.4	0.0	-0.4	0.4	0.0	-0.7	0.5
Mg content in liver	0.5	0.5	1.0	0.1	-1.0	1.0	0.2	-1.0	-0.2
Mn content in liver	0.3	0.4	0.7	-0.3	-0.8	0.8	0.0	-0.3	-0.8
Na content in liver	0.8	0.9	1.6	-1.3	-1.1	1.1	-0.7	-0.8	0.2
Rb content in liver	1.6	2.0	3.3	1.8	1.7	-1.7	1.2	0.8	0.7
Se content in liver	0.8	1.0	3.0	1.5	0.2	-0.1	1.7	-0.7	-0.5
Sr content in liver	0.5	0.5	0.8	-0.8	-0.7	0.7	-0.9	-0.5	0.6
Zn content in liver	1.0	1.1	2.2	-0.3	-1.5	1.5	0.1	-1.5	-0.4
Bone: minimum diameter	0.6	1.1	2.2	-1.3	0.4	-0.4	-1.5	1.4	0.7
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.0	0.5	-0.4	0.1	0.5	-0.3
Time in novel zone, hab. session 1	0.7	0.7	1.6	0.5	0.8	-0.8	-0.4	0.7	1.3
Total zone transitions, hab. session 1	1.7	2.4	6.5	-2.4	-0.6	0.5	-2.6	0.7	1.0
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.8	0.4	-0.4	-0.9	0.8	0.4
Locomotion velocity, hab. session 1	0.2	0.3	0.7	-0.9	-0.6	0.6	-0.5	-0.3	-0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.5	0.0	0.0	0.6	-0.7	0.0
Time in novel zone, hab. session 2	0.6	0.6	1.9	-0.4	0.5	-0.6	-0.8	1.4	0.4
Total zone transitions, hab. session 2	0.5	0.6	1.3	-0.4	-0.8	0.8	0.4	-1.2	-0.9
Total locomotion distance, hab. session 2	0.8	1.0	2.7	-0.0	-0.8	0.9	0.9	-1.6	-1.1
Locomotion velocity, hab. session 2	0.9	1.2	2.9	-0.0	-0.9	0.9	1.0	-1.7	-1.3
Novel to familiar place preference ratio	0.1	0.1	0.2	0.3	-0.1	0.1	0.4	-0.2	-0.1
Novelty place preference	0.0	0.1	0.1	0.4	0.1	-0.1	0.4	-0.1	0.0
Time in novel zone, NPP test	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	0.1	0.2
Total zone transitions, NPP test	1.0	1.4	2.0	-1.3	-1.4	1.4	-1.0	-1.3	0.0
Total locomotion distance, NPP test	0.7	0.9	1.5	-1.1	-1.1	1.1	-0.6	-1.2	-0.1
Locomotion velocity, NPP test	0.5	0.7	1.2	-0.9	-1.0	1.0	-0.5	-1.1	-0.1
Intraocular pressure	1.0	1.5	4.1	2.0	1.0	-1.0	0.7	-0.5	1.3
Delta distance traveled before/after self-admin	1.0	1.0	2.4	-0.6	0.7	-0.7	-1.4	1.5	0.7
Delta ambulatory time before/after self-admin	1.3	1.4	3.4	-0.1	1.1	-1.1	-1.4	1.8	0.9
Parametrial fat weight	0.1	0.1	0.4	-0.3	0.3	-0.3	0.0	-0.1	0.6
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.6	0.7	-0.6	0.7	0.4	-0.6
Pavlov. Cond. magazine entry latency	1.4	1.8	4.5	-2.0	-0.4	0.3	-2.1	0.5	1.2
Pavlov. Cond. change in total contacts	0.9	0.9	2.4	-0.9	-0.7	0.7	-1.6	-0.2	1.2
Pavlov. Cond. index score	0.9	1.2	2.9	-1.4	-0.7	0.6	-1.7	-0.0	1.1
Pavlov. Cond. latency score	0.7	0.9	1.9	-1.3	-0.8	0.8	-1.4	-0.2	0.7
Pavlov. Cond. lever contacts	0.3	0.4	0.9	-0.6	-0.3	0.3	-0.9	-0.1	0.9
Pavlov. Cond. magazine entry number	1.9	2.4	6.2	2.2	0.3	-0.3	2.5	-0.6	-1.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.9	1.0	0.1	-0.0	1.4	-0.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.4	-1.2	-0.5	0.5	-1.5	-0.0	1.2
Pavlov. Cond. response bias	1.3	1.6	4.2	-1.5	-0.2	0.2	-2.0	0.4	1.7
Pavlov. Cond. lever latency	0.3	0.4	1.4	1.2	0.5	-0.5	0.4	-0.2	0.6
Pavlov. Cond. magazine entry latency	1.6	1.8	3.0	-0.1	1.7	-1.7	-0.7	1.7	1.3
Pavlov. Cond. change in total contacts	0.5	0.7	1.4	-0.7	0.5	-0.6	-1.0	1.2	0.7
Pavlov. Cond. index score	0.4	0.6	1.1	-1.0	0.3	-0.3	-1.0	0.9	0.6
Pavlov. Cond. latency score	0.4	0.4	0.9	-0.9	0.3	-0.3	-0.9	0.8	0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.8	-0.4	0.4	0.0	0.1	-0.7
Pavlov. Cond. magazine entry number	1.1	1.3	1.9	0.0	-1.4	1.4	0.8	-1.3	-1.4
Pavlov. Cond. intertrial magazine entries	2.1	2.8	5.1	-1.5	-2.3	2.2	-0.4	-1.2	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	-1.0	0.2	-0.2	-0.9	0.6	0.6
Pavlov. Cond. response bias	0.2	0.3	1.0	-0.6	0.4	-0.4	-0.5	1.0	0.1
Time in closed arm before self-admin	0.4	0.5	1.3	1.1	0.4	-0.4	1.0	-0.4	-0.0
Time in closed arm after self-admin	0.7	0.7	2.7	-0.3	0.1	-0.1	-1.2	-0.1	1.7
Time in open arm before self-admin	0.3	0.3	1.0	-0.2	0.5	-0.5	-0.5	1.0	-0.1
Time in open arm after self-admin	0.6	0.7	1.9	1.2	-0.1	0.1	1.4	-0.7	-0.4
Bone: periosteal estimation	0.7	1.4	3.1	-1.2	0.6	-0.6	-1.8	1.3	1.3
Bone: periosteal perimeter	0.6	1.1	2.6	-1.3	-0.0	0.0	-1.6	0.5	1.4
Bone: post-yield work	0.8	1.1	2.2	1.2	1.2	-1.2	0.1	0.5	1.5
Progressive ratio test 1 active lever presses	1.5	1.6	4.1	-1.0	0.3	-0.3	-2.0	1.5	1.4
Progressive ratio test 1 breakpoint	1.3	1.4	3.7	-0.9	0.3	-0.3	-1.9	1.4	1.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	2.4	-1.2	-0.4	0.4	-1.5	0.6	0.9
Progressive ratio test 2 active lever presses	0.4	0.4	1.5	-0.5	0.5	-0.5	-0.6	1.2	-0.1
Progressive ratio test 2 breakpoint	0.3	0.4	1.2	-0.6	0.3	-0.4	-0.7	1.1	-0.0
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.9	-1.4	0.2	-0.2	-1.3	1.4	0.1
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.5	0.2	-0.2	0.3	0.5	-0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	0.2	-0.2	0.3	0.4	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	2.0	-1.4	-0.4	0.4	0.1	-0.2	-0.6
Progressive ratio	1.4	1.6	3.0	-1.7	-1.4	1.4	-1.1	-1.2	0.5
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.2	0.2	-0.2	0.3	0.4	-0.2
Seeking ratio, punishment vs. effort	1.2	1.5	2.2	1.4	1.5	-1.5	0.9	1.3	-0.2
Retroperitoneal fat weight	0.3	0.9	3.6	0.2	0.9	-0.9	-0.4	0.4	1.9
Reaction time number correct	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.6	0.2	0.2
Reaction time mean minus median	1.0	1.3	2.6	-1.3	0.4	-0.4	-1.6	0.8	1.5
Reaction time mean minus median AUC	0.8	1.0	2.5	-1.1	0.4	-0.4	-1.4	0.5	1.6
Reaction time num false alarms	0.7	0.9	2.1	-1.5	-1.1	1.0	-0.9	-0.2	-0.6
Reaction time num false alarms AUC	0.5	0.7	1.5	-1.2	-0.9	0.9	-0.8	-0.2	-0.5
Reaction time trials correct on left	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.6	0.2	0.2
Reaction time trials on left	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.6	0.3	0.2
Reaction time mean	0.7	1.0	1.8	0.7	1.3	-1.3	0.7	1.1	0.0
Reaction time mean AUC	0.9	1.3	2.5	0.7	1.6	-1.6	0.7	1.3	0.1
Median of all reaction times	1.3	1.8	2.5	1.4	1.6	-1.6	1.4	1.2	-0.6
Reaction time omissions	0.5	0.6	1.3	-0.3	1.1	-1.1	-0.2	1.2	0.1
Reaction time false alarm rate	0.3	0.5	1.0	-1.0	-0.8	0.8	-0.5	-0.4	-0.4
Reaction time premature initiation rate	1.8	2.4	4.1	-1.8	-2.0	2.0	-0.3	-1.5	-0.8
Reaction time premature initiations	1.3	1.9	3.8	-2.0	-1.7	1.7	-0.8	-1.0	-0.4
Std. dev. reaction times	0.7	1.0	2.0	-0.5	1.0	-1.0	-0.9	1.0	1.4
Reaction time trials completed	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.6	0.3	0.2
Reaction time trials AUC	0.1	0.1	0.3	-0.1	-0.0	0.0	-0.5	0.3	0.3
Run reversals in cocaine runway, females	1.4	1.3	3.1	-0.0	0.9	-0.9	0.8	1.6	-1.8
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.7	0.4	-0.4	0.1	0.7	-0.1
Latency to leave start box in cocaine runway	0.1	0.2	0.3	0.5	-0.4	0.4	0.3	-0.6	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	0.7	0.2	-0.2	0.5	0.0	-0.2
Latency to leave start box in cocaine runway, M	0.7	0.6	1.4	-0.0	-1.1	1.1	-0.2	-1.2	-0.1
Std. dev. time between licks in bursts	1.7	2.1	3.3	-0.6	-1.8	1.8	0.6	-1.6	-1.7
Total sessions with >9 infusions	0.8	0.9	2.0	-1.2	0.2	-0.3	-1.4	1.0	0.9
Short access day 1 total inactive lever presses	2.3	2.5	4.7	-2.2	-1.8	1.8	-1.9	-0.4	-0.5
Short access day 10 total inactive lever presses	0.6	0.7	1.8	-1.3	-0.7	0.7	-1.2	-0.2	0.1
Short access day 1 total infusions	0.6	0.6	1.5	-0.0	0.8	-0.8	-0.6	1.2	0.7
Short access day 10 total infusions	0.7	0.8	2.4	-1.0	-0.3	0.3	-1.5	0.5	1.0
Short access total infusions	0.3	0.4	0.9	-0.6	0.1	-0.2	-0.9	0.5	0.9
Short access day 1 locomotion	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.5	0.2	0.0
Short access day 10 total locomotion	0.4	0.4	0.8	-0.9	-0.5	0.5	-0.7	0.3	-0.7
Short access total locomotion	0.7	0.7	2.1	-0.9	-0.3	0.3	-1.4	0.3	1.0
One hour access (0.3 mA shock)	0.6	0.7	2.4	-0.4	-0.9	0.9	0.2	-0.0	-1.5
Compulsive drug intake	0.8	0.8	1.4	0.4	-0.7	0.7	1.2	-0.9	-1.1
One hour access (shock baseline)	0.3	0.3	0.9	-0.6	0.1	-0.1	-0.9	0.8	0.2
Social response proportion	0.4	0.4	1.3	-0.8	0.4	-0.4	-0.6	1.1	-0.0
Social responses	1.5	1.9	5.0	-2.2	-0.9	0.8	-2.0	0.8	0.3
Social time	0.3	0.4	0.9	0.3	0.8	-0.8	0.0	1.0	0.4
Soleus weight	1.0	2.9	4.8	-0.4	1.6	-1.7	-1.6	2.1	2.2
Bone: stiffness	1.3	2.1	5.5	-2.0	-0.4	0.3	-2.3	0.7	1.5
Tibialis anterior weight	0.1	0.4	1.6	-0.3	0.3	-0.3	-0.9	0.1	1.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.7	0.1	-0.1	-0.0	-0.4	0.6
Time to tail flick, vehicle, after self-admin	2.2	2.3	4.9	0.1	-2.0	2.0	0.5	-2.2	-1.1
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.1	-0.3	0.3	-0.5	-0.3	0.8
Time to tail flick, test, after self-admin	2.3	2.4	5.2	0.1	-1.5	1.6	1.3	-1.7	-2.3
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	3.7	0.0	-1.6	1.7	1.4	-1.9	-1.9
Delta time to tail flick, test, before/after SA	0.9	0.8	3.2	0.2	-0.6	0.6	0.7	-0.5	-1.8
Tibia length	0.4	1.1	3.0	-1.6	-0.1	0.0	-1.7	0.7	0.9
Ambulatory time before self-admin	0.9	1.0	2.7	0.9	-0.9	0.9	0.6	-1.6	0.4
Ambulatory time after self-admin	0.2	0.2	0.4	0.1	-0.5	0.4	-0.4	-0.2	0.6
Bone: tissue strength	1.5	1.4	3.0	0.8	1.5	-1.5	-0.2	1.7	0.4
Total heroin consumption	0.2	0.2	0.6	0.7	0.3	-0.2	0.2	-0.2	0.8
Bone: trabecular number	1.0	1.6	3.3	0.5	1.8	-1.8	-0.0	1.3	1.1
Bone: trabecular spacing	0.8	1.1	2.1	0.3	-1.1	1.1	0.8	-1.0	-1.4
Bone: trabecular thickness	1.2	1.4	2.5	1.2	1.6	-1.6	0.4	0.5	1.3
Bone: trabecular tissue density	1.2	1.6	3.7	-1.9	-1.5	1.4	-1.1	-0.8	-0.2
Water consumed over 24 hours	1.0	1.2	4.5	-2.1	-0.6	0.5	-1.4	0.1	0.2
Number of responses in last shaping day	0.8	0.8	1.3	0.8	1.0	-1.0	-0.2	0.8	1.1