Slc40a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Slc40a1 0.19 0.1 0.0e+00 0.09 0.1 0.07 0.09 3.1e-10 5.9e-11 2.0e-08 1.3e-10
2 pVTA gene expression Slc40a1 0.15 0.09 1.3e-05 0.03 0.1 0.13 0.09 1.3e-02 5.4e-05 4.4e-06 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.62.63.6-1.91.3
Area under the delay curve0.10.10.1-0.4-0.3
BMI with tail1.13.65.12.3-1.5
BMI without tail0.00.00.00.10.0
Body weight0.10.30.30.5-0.5
Weight adjusted by age1.11.31.91.4-0.8
Bone surface0.00.00.00.2-0.1
Bone volume0.30.50.7-0.90.6
Breakpoint value in progressive ratio session0.80.91.3-0.71.2
Number of licking bursts2.12.52.8-1.51.7
Context. condit. distance diff. score1.01.21.4-1.11.2
Locomotion velocity, session 10.00.10.1-0.30.1
Locomotion distance, session 10.20.30.40.7-0.3
Locomotion velocity, session 21.61.92.01.4-1.3
Locomotion distance, session 21.11.51.91.4-1.1
Locomotion velocity, session 30.00.00.00.20.2
Locomotion distance, session 30.60.71.3-0.31.1
Stereotopy head waving bouts, day 30.30.30.40.7-0.4
Stereotopy head waving duration, day 30.00.00.1-0.0-0.2
Locomotion velocity, session 71.92.12.41.5-1.4
Locomotion distance, session 71.62.02.01.4-1.4
Stereotopy head waving bouts, day 70.40.50.5-0.70.7
Stereotopy head waving duration, day 70.50.60.7-0.80.7
Locomotion velocity, session 80.10.10.1-0.20.3
Locomotion distance, session 80.00.00.10.2-0.1
Degree of sensitization distance2.32.33.11.2-1.8
Degree of sensitization stereotypy0.80.91.0-0.91.0
Conditioned locomotion0.10.10.1-0.40.3
Cocaine response after cond. corrected1.92.12.51.3-1.6
Cocaine response after cond. not corrected1.92.12.41.3-1.6
Cocaine response before conditioning0.00.00.00.1-0.0
Saline control response0.40.60.7-0.70.9
Bone: connectivity density0.20.20.3-0.50.5
Bone: cortical apparent density3.74.96.32.5-1.9
Bone: cortical area0.71.11.51.2-0.8
Bone: cortical porosity0.70.81.1-1.10.7
Bone: cortical porosity0.60.60.8-0.90.7
Bone: cortical thickness0.60.91.71.3-0.5
Bone: cortical thickness0.20.20.20.4-0.4
Bone: cortical tissue density3.74.96.32.5-1.9
Condit. Reinf. active minus inactive responses2.32.63.5-1.91.3
Condit. Reinf. active-inactive response ratio1.51.62.1-1.41.1
Condit. Reinf. active responses0.80.91.6-1.30.5
Condit. Reinf. inactive responses0.40.50.90.4-0.9
Incentive salience index mean2.22.63.7-1.91.2
Condit. Reinf. lever presses1.21.62.4-1.50.9
Condit. Reinf. active minus inactive responses0.80.91.1-1.10.8
Condit. Reinf. active-inactive response ratio2.32.42.9-1.41.7
Condit. Reinf. active responses0.10.10.3-0.2-0.5
Condit. Reinf. inactive responses1.41.72.60.9-1.6
Condit. Reinf. lever presses0.10.10.20.1-0.5
Condit. Reinf. lever reinforcers received0.20.20.50.0-0.7
Conditioned reinforcement - actives0.40.40.6-0.40.8
Conditioned reinforcement - inactives0.50.51.1-0.11.0
Conditioned locomotion3.74.45.82.4-1.7
Patch foraging indifference point 0 sec1.01.62.31.5-1.0
Patch foraging indifference point AUC1.61.92.61.1-1.6
Delay disc. indifference point, 0s delay0.00.00.1-0.2-0.2
Delay disc. indifference point, 16s delay0.50.50.8-0.90.3
Delay disc. indifference point, 2s delay0.00.00.10.1-0.3
Delay disc. indifference point, 24s delay0.50.50.7-0.80.6
Delay disc. indifference point, 4s delay0.80.81.40.4-1.2
Delay disc. indifference point, 8s delay0.10.10.2-0.4-0.1
Indifference point function ln k0.91.32.0-0.81.4
Indifference point function log k0.91.32.0-0.81.4
Patch foraging total patch changes 0 sec1.01.62.51.6-0.9
Patch foraging total patch changes 12 sec0.91.11.31.0-1.1
Patch foraging total patch changes 18 sec1.21.51.81.1-1.3
Patch foraging total patch changes 24 sec1.11.31.61.0-1.2
Patch foraging total patch changes 6 sec1.52.32.51.6-1.4
Patch foraging time to switch 0 sec0.71.11.2-1.01.1
Patch foraging water rate 0 sec0.60.91.01.0-1.0
Patch foraging water rate 12 sec0.20.40.6-0.30.8
Patch foraging water rate 18 sec1.11.52.0-1.01.4
Patch foraging water rate 24 sec0.00.00.00.00.2
Patch foraging water rate 6 sec0.10.10.2-0.20.4
Seeking ratio, delayed vs. immediate footshock0.40.40.5-0.70.6
Distance traveled before self-admin0.00.00.1-0.30.1
Distance traveled after self-admin0.00.00.00.10.0
Extensor digitorum longus weight8.031.739.46.3-4.9
Bone: elastic displacement1.92.12.3-1.51.4
Bone: elastic work0.40.50.6-0.80.7
Bone: endosteal estimation0.10.20.3-0.0-0.6
Bone: endosteal perimeter0.00.00.0-0.1-0.1
Epididymis fat weight0.10.10.10.3-0.4
Delta time in closed arm before/after self-admin1.51.51.51.2-1.2
Delta time in open arm before/after self-admin2.01.92.2-1.51.3
Diff in mean of infusions in LGA sessions1.21.31.6-1.31.0
Delay discount exponential model param0.10.10.20.50.2
Extinction: sum of active levers before priming0.40.40.5-0.70.6
Active lever presses in extinction session 61.11.11.4-0.91.2
Bone: final force1.01.61.61.2-1.3
Bone: final moment1.01.61.61.2-1.2
Food consumed during 24 hour testing period0.50.60.90.5-1.0
Glucose0.40.60.8-0.90.5
Heart weight0.00.00.1-0.1-0.3
Delay discount hyperbolic model param0.10.10.20.20.5
Intermittent access intake day 1-15 change0.10.10.3-0.10.5
Intermittent access intake escalation0.50.50.7-0.50.8
Intermittent access intake escalation 20.70.60.7-0.80.8
Intermitt. access day 1 inactive lever presses0.30.40.60.30.8
Intermitt. access day 15 inactive lever presses0.60.61.1-0.41.0
Intermitt. access escalation Index0.00.00.0-0.1-0.0
Intermittent access day 1 total infusions3.23.75.8-1.32.4
Intermittent access day 15 total infusions3.13.55.3-1.32.3
Intermittent access terminal intake (last 3 days)2.12.33.8-0.92.0
Intermittent access total infusions2.52.84.3-1.12.1
Intermittent access day 1 locomotion1.51.63.2-0.31.8
Intermittent access day 15 total locomotion0.20.20.30.10.6
Intermittent access total locomotion1.21.42.8-0.21.7
Intermittent access standard deviation0.60.61.20.21.1
Left kidney weight0.20.60.90.5-1.0
Right kidney weight1.02.73.21.4-1.8
Cocaine induced anxiety3.03.54.42.1-1.6
Post-drug Anxiety0.40.50.70.8-0.5
Baseline Anxiety3.53.74.4-2.11.7
Tail length0.72.23.3-1.81.0
Length with tail0.20.61.2-1.10.3
Length without tail1.22.62.81.6-1.7
Times rat made contact with spout1.82.02.2-1.51.4
Lifetime Intake1.01.22.0-0.61.4
Liver weight, left1.62.62.81.5-1.7
Liver weight, right0.30.50.60.7-0.7
Locomotor activity0.00.10.10.40.1
Locomotor testing distance0.50.80.8-0.90.9
Locomotor testing rearing1.11.82.2-1.21.5
Locomotion in novel chamber4.35.35.62.4-2.2
Locomotion in novel chamber post-restriction4.75.76.42.3-2.5
Fecal boli incidents, locomotor time 10.00.00.0-0.10.2
Change in fecal boli incidents, locomotor task0.20.20.2-0.40.4
Time >=10cm from walls, locomotor time 11.01.01.31.1-0.9
Bouts of movement, locomotor time 10.40.40.70.80.2
Total resting periods, locomotor time 10.70.81.41.2-0.3
Rest time, locomotor task time 10.10.10.1-0.20.4
Distance moved, locomotor task time 10.10.10.1-0.40.3
Vertical activity count, locomotor time 10.00.00.00.20.1
Time >=10cm from walls, locomotor time 21.41.51.6-1.31.2
Bouts of movement, locomotor time 21.21.22.31.5-0.4
Total resting periods, locomotor time 21.11.12.21.5-0.3
Rest time, locomotor task time 20.00.00.00.20.1
Distance moved, locomotor task time 20.10.10.1-0.40.1
Vertical activity count, locomotor time 20.00.00.1-0.1-0.3
Light reinforcement 13.87.08.62.9-2.3
Light reinforcement 21.21.61.71.2-1.3
Bone: marrow area0.10.20.30.0-0.6
Bone: maximum diameter0.10.30.40.6-0.4
Bone: maximum force0.91.61.81.2-1.3
Bone: maximum moment0.91.51.61.1-1.3
Mean time between licks in bursts3.04.24.92.2-1.9
Mean num. licks in bursts0.50.60.80.7-0.9
Cd content in liver0.20.20.30.4-0.6
Co content in liver1.51.82.5-1.61.0
Cu content in liver1.72.02.7-1.61.1
Fe content in liver2.42.83.3-1.81.5
K content in liver3.02.93.11.8-1.7
Mg content in liver1.41.41.71.1-1.3
Mn content in liver0.00.00.0-0.0-0.2
Na content in liver0.50.50.90.3-0.9
Rb content in liver3.84.75.61.9-2.4
Se content in liver0.10.10.20.5-0.3
Sr content in liver0.40.30.6-0.20.8
Zn content in liver0.10.20.30.60.0
Bone: minimum diameter0.51.01.31.1-0.9
Time in familiar zone, hab. session 10.10.10.2-0.40.1
Time in novel zone, hab. session 12.32.22.9-1.71.2
Total zone transitions, hab. session 10.60.80.91.0-0.9
Total locomotion distance, hab. session 11.01.51.71.3-1.1
Locomotion velocity, hab. session 11.82.53.31.8-1.3
Time in familiar zone, hab. session 20.10.10.2-0.4-0.2
Time in novel zone, hab. session 20.60.60.8-0.60.9
Total zone transitions, hab. session 20.10.10.1-0.20.4
Total locomotion distance, hab. session 20.00.10.10.3-0.2
Locomotion velocity, hab. session 20.20.20.30.5-0.4
Novel to familiar place preference ratio1.11.11.2-1.01.1
Novelty place preference1.51.51.7-1.21.3
Time in novel zone, NPP test1.81.91.9-1.31.4
Total zone transitions, NPP test0.10.20.20.5-0.3
Total locomotion distance, NPP test0.10.20.30.6-0.3
Locomotion velocity, NPP test0.40.50.80.9-0.4
Intraocular pressure0.10.20.3-0.50.3
Delta distance traveled before/after self-admin0.20.20.30.4-0.6
Delta ambulatory time before/after self-admin0.30.30.40.5-0.6
Parametrial fat weight0.00.00.0-0.00.1
Pavlov. Cond. lever latency3.24.04.51.9-2.1
Pavlov. Cond. magazine entry latency1.82.32.6-1.61.4
Pavlov. Cond. change in total contacts2.12.22.4-1.51.4
Pavlov. Cond. index score3.84.84.8-2.22.2
Pavlov. Cond. latency score3.54.54.6-2.12.1
Pavlov. Cond. lever contacts3.23.74.0-1.92.0
Pavlov. Cond. magazine entry number3.94.95.52.4-2.0
Pavlov. Cond. intertrial magazine entries0.20.30.50.3-0.7
Pavlov. Cond. lever-magazine prob. diff.3.03.83.8-1.92.0
Pavlov. Cond. response bias3.23.94.4-2.11.9
Pavlov. Cond. lever latency0.30.30.70.20.8
Pavlov. Cond. magazine entry latency0.20.20.3-0.2-0.6
Pavlov. Cond. change in total contacts0.20.30.6-0.8-0.2
Pavlov. Cond. index score0.20.30.6-0.2-0.7
Pavlov. Cond. latency score0.30.30.6-0.1-0.8
Pavlov. Cond. lever contacts0.20.30.5-0.4-0.7
Pavlov. Cond. magazine entry number0.20.20.40.60.1
Pavlov. Cond. intertrial magazine entries0.20.20.40.70.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.0-0.9
Pavlov. Cond. response bias0.30.50.9-0.1-0.9
Time in closed arm before self-admin1.01.11.9-1.40.5
Time in closed arm after self-admin0.80.81.60.2-1.3
Time in open arm before self-admin0.50.51.01.0-0.1
Time in open arm after self-admin1.71.92.3-1.21.5
Bone: periosteal estimation0.20.30.40.5-0.6
Bone: periosteal perimeter0.00.00.00.10.1
Bone: post-yield work0.20.30.50.3-0.7
Progressive ratio test 1 active lever presses0.20.30.50.10.7
Progressive ratio test 1 breakpoint0.10.10.20.20.4
Progressive ratio test 1 inactive lever presses0.10.10.20.50.1
Progressive ratio test 2 active lever presses1.21.32.2-0.71.5
Progressive ratio test 2 breakpoint1.21.32.0-0.81.4
Progressive ratio test 2 inactive lever presses1.41.62.9-0.51.7
Incentive Sensitization - Responses0.80.81.2-0.61.1
Incentive Sensitization - Breakpoint0.70.71.0-0.61.0
Sum of active levers in priming session hrs 5-60.80.81.0-1.00.8
Progressive ratio0.30.40.60.5-0.7
Food seeking constrained by brief footshock1.41.82.80.8-1.7
Seeking ratio, punishment vs. effort0.20.20.30.4-0.5
Retroperitoneal fat weight0.41.42.11.5-0.8
Reaction time number correct1.21.72.01.2-1.4
Reaction time mean minus median0.70.91.6-1.30.5
Reaction time mean minus median AUC0.60.81.4-1.20.3
Reaction time num false alarms3.44.75.62.4-1.9
Reaction time num false alarms AUC4.66.37.72.8-2.2
Reaction time trials correct on left1.21.72.01.2-1.4
Reaction time trials on left1.21.72.01.1-1.4
Reaction time mean3.14.35.0-2.21.9
Reaction time mean AUC3.14.14.6-2.11.9
Median of all reaction times3.75.05.1-2.32.2
Reaction time omissions1.42.02.6-1.61.2
Reaction time false alarm rate1.62.33.21.8-1.2
Reaction time premature initiation rate0.40.50.9-0.21.0
Reaction time premature initiations0.00.10.10.30.1
Std. dev. reaction times2.23.14.4-2.11.4
Reaction time trials completed1.21.72.01.1-1.4
Reaction time trials AUC0.91.31.51.1-1.2
Run reversals in cocaine runway, females1.91.82.21.5-1.2
Run reversals in cocaine runway, males3.73.55.51.3-2.3
Latency to leave start box in cocaine runway4.04.44.62.0-2.1
Latency to leave start box in cocaine runway, F1.41.51.71.2-1.3
Latency to leave start box in cocaine runway, M4.03.94.12.0-1.9
Std. dev. time between licks in bursts2.02.43.41.8-1.2
Total sessions with >9 infusions2.22.43.61.9-1.1
Short access day 1 total inactive lever presses1.21.41.81.0-1.3
Short access day 10 total inactive lever presses0.10.10.2-0.10.5
Short access day 1 total infusions0.90.91.01.0-0.9
Short access day 10 total infusions2.62.94.0-1.32.0
Short access total infusions0.10.10.10.30.3
Short access day 1 locomotion1.71.91.91.4-1.4
Short access day 10 total locomotion0.30.30.60.30.8
Short access total locomotion2.02.13.41.8-0.9
One hour access (0.3 mA shock)1.72.02.1-1.41.5
Compulsive drug intake0.20.20.3-0.2-0.5
One hour access (shock baseline)1.82.12.8-1.21.7
Social response proportion0.30.30.4-0.60.5
Social responses0.00.00.00.20.0
Social time1.31.72.1-1.51.2
Soleus weight1.95.66.12.5-2.3
Bone: stiffness1.32.12.41.3-1.5
Tibialis anterior weight2.99.813.43.7-2.5
Time to tail flick, vehicle, before self-admin0.20.20.4-0.10.6
Time to tail flick, vehicle, after self-admin0.30.30.5-0.70.4
Time to tail flick, test, before self-admin3.23.14.31.4-2.1
Time to tail flick, test, after self-admin2.22.32.61.6-1.4
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.3-0.1
Delta time to tail flick, test, before/after SA0.30.30.5-0.20.7
Tibia length0.10.40.80.0-0.9
Ambulatory time before self-admin0.10.10.2-0.4-0.0
Ambulatory time after self-admin0.10.20.30.5-0.3
Bone: tissue strength0.10.10.10.3-0.2
Total heroin consumption1.01.21.2-1.11.1
Bone: trabecular number0.40.60.9-1.00.5
Bone: trabecular spacing0.70.91.21.1-0.8
Bone: trabecular thickness4.04.86.3-2.51.8
Bone: trabecular tissue density0.20.30.50.2-0.7
Water consumed over 24 hours0.00.00.10.1-0.2
Number of responses in last shaping day0.50.50.90.4-0.9