Hub : Genes

Slc26a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Slc26a6 0.02 0.02 2.7e-03 0.01 0.01 0.01 0.01 8.5e-03 4.5e-02 1.5e-02 5.6e-02
2 IL intron excision ratio chr8_118443216_118443341 0.22 0.13 6.1e-03 0.06 0.03 0.03 0.05 1.6e-02 7.3e-02 7.7e-02 2.5e-02
3 IL intron excision ratio chr8_118443169_118443341 0.25 0.14 2.3e-03 0.07 0.04 0.05 0.07 8.2e-03 3.5e-02 3.0e-02 7.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.81.32.10.21.4-1.4
Area under the delay curve0.81.01.51.20.8-0.8
BMI with tail0.00.10.2-0.50.40.1
BMI without tail0.72.02.4-1.51.5-1.2
Body weight1.56.719.2-4.40.9-0.4
Weight adjusted by age0.50.71.1-0.4-1.01.0
Bone surface0.10.20.50.70.4-0.3
Bone volume0.20.40.50.60.7-0.7
Breakpoint value in progressive ratio session0.10.10.20.30.4-0.4
Number of licking bursts1.52.43.50.6-1.91.8
Context. condit. distance diff. score0.00.00.0-0.0-0.20.2
Locomotion velocity, session 10.20.20.30.10.6-0.5
Locomotion distance, session 11.62.02.7-1.21.7-1.4
Locomotion velocity, session 20.10.10.20.4-0.10.3
Locomotion distance, session 20.91.22.2-0.01.5-1.2
Locomotion velocity, session 31.71.93.4-0.11.8-1.5
Locomotion distance, session 31.01.11.31.21.1-0.8
Stereotopy head waving bouts, day 31.92.23.3-0.2-1.81.8
Stereotopy head waving duration, day 30.81.01.4-0.6-1.21.1
Locomotion velocity, session 71.31.42.2-0.21.4-1.5
Locomotion distance, session 70.70.91.41.20.8-0.8
Stereotopy head waving bouts, day 70.10.10.1-0.20.3-0.3
Stereotopy head waving duration, day 70.40.50.7-0.90.6-0.6
Locomotion velocity, session 81.21.52.5-0.61.6-1.2
Locomotion distance, session 82.43.45.7-0.62.4-2.0
Degree of sensitization distance0.40.41.1-1.0-0.2-0.0
Degree of sensitization stereotypy0.90.91.4-0.41.1-1.2
Conditioned locomotion1.11.33.71.90.3-0.4
Cocaine response after cond. corrected1.41.72.5-0.6-1.51.6
Cocaine response after cond. not corrected1.11.32.0-1.4-0.91.0
Cocaine response before conditioning1.11.41.7-1.01.3-1.2
Saline control response0.81.11.6-0.81.0-1.3
Bone: connectivity density1.01.52.30.71.3-1.5
Bone: cortical apparent density0.10.20.20.40.4-0.5
Bone: cortical area1.42.23.40.4-1.71.8
Bone: cortical porosity1.61.72.90.31.4-1.7
Bone: cortical porosity1.41.52.70.31.3-1.6
Bone: cortical thickness1.62.74.3-0.3-1.92.1
Bone: cortical thickness0.20.30.40.2-0.60.6
Bone: cortical tissue density0.10.20.20.40.4-0.5
Condit. Reinf. active minus inactive responses0.60.71.1-0.4-1.00.9
Condit. Reinf. active-inactive response ratio1.31.42.1-0.5-1.51.3
Condit. Reinf. active responses0.30.40.6-0.0-0.80.7
Condit. Reinf. inactive responses0.20.20.50.70.4-0.3
Incentive salience index mean0.20.30.40.1-0.60.6
Condit. Reinf. lever presses0.50.72.01.4-0.20.4
Condit. Reinf. active minus inactive responses0.40.51.4-1.2-0.20.3
Condit. Reinf. active-inactive response ratio0.50.61.4-1.2-0.20.5
Condit. Reinf. active responses0.30.41.2-1.1-0.10.2
Condit. Reinf. inactive responses0.10.10.10.4-0.20.1
Condit. Reinf. lever presses0.71.02.8-1.70.5-0.3
Condit. Reinf. lever reinforcers received0.40.61.7-1.3-0.10.2
Conditioned reinforcement - actives1.11.82.81.7-1.11.2
Conditioned reinforcement - inactives3.95.77.11.8-2.62.7
Conditioned locomotion0.20.20.30.60.4-0.4
Patch foraging indifference point 0 sec1.12.02.2-1.51.3-1.5
Patch foraging indifference point AUC0.81.21.7-0.21.3-1.3
Delay disc. indifference point, 0s delay0.10.10.1-0.10.3-0.3
Delay disc. indifference point, 16s delay0.40.50.80.90.5-0.5
Delay disc. indifference point, 2s delay0.10.10.20.40.3-0.3
Delay disc. indifference point, 24s delay0.40.50.91.00.5-0.5
Delay disc. indifference point, 4s delay0.40.51.41.20.0-0.0
Delay disc. indifference point, 8s delay0.80.91.81.40.7-0.7
Indifference point function ln k0.10.20.50.70.10.2
Indifference point function log k0.10.20.50.70.10.2
Patch foraging total patch changes 0 sec0.81.52.3-1.50.9-1.1
Patch foraging total patch changes 12 sec0.40.61.2-1.10.5-0.6
Patch foraging total patch changes 18 sec1.32.02.7-1.61.1-1.5
Patch foraging total patch changes 24 sec0.71.23.2-1.80.4-0.4
Patch foraging total patch changes 6 sec1.01.52.3-0.71.3-1.5
Patch foraging time to switch 0 sec0.61.31.80.5-1.41.3
Patch foraging water rate 0 sec0.00.10.2-0.5-0.10.1
Patch foraging water rate 12 sec0.10.10.4-0.60.2-0.1
Patch foraging water rate 18 sec0.20.30.6-0.2-0.50.8
Patch foraging water rate 24 sec0.40.51.2-1.1-0.40.4
Patch foraging water rate 6 sec0.20.30.4-0.60.5-0.4
Seeking ratio, delayed vs. immediate footshock0.81.02.21.50.7-0.7
Distance traveled before self-admin1.21.62.10.8-1.41.5
Distance traveled after self-admin0.40.50.60.6-0.80.8
Extensor digitorum longus weight0.31.21.21.1-1.11.1
Bone: elastic displacement0.60.71.1-0.1-1.01.0
Bone: elastic work0.30.40.6-0.6-0.60.8
Bone: endosteal estimation0.30.71.1-0.21.0-1.1
Bone: endosteal perimeter0.30.61.81.30.1-0.1
Epididymis fat weight0.10.30.8-0.9-0.00.1
Delta time in closed arm before/after self-admin0.30.30.80.90.2-0.2
Delta time in open arm before/after self-admin0.10.10.3-0.60.0-0.0
Diff in mean of infusions in LGA sessions2.02.43.6-0.3-1.91.9
Delay discount exponential model param0.91.01.7-1.3-0.80.8
Extinction: sum of active levers before priming0.50.60.80.10.9-0.9
Active lever presses in extinction session 60.90.91.4-0.31.1-1.2
Bone: final force0.71.12.2-1.5-0.70.9
Bone: final moment0.91.42.6-1.6-0.81.0
Food consumed during 24 hour testing period0.50.72.1-1.40.1-0.0
Glucose1.11.82.2-1.01.5-1.5
Heart weight2.03.03.3-1.7-1.71.8
Delay discount hyperbolic model param0.80.91.9-1.4-0.60.6
Intermittent access intake day 1-15 change1.12.22.61.3-1.61.6
Intermittent access intake escalation1.42.93.31.5-1.81.8
Intermittent access intake escalation 22.32.63.80.7-1.91.9
Intermitt. access day 1 inactive lever presses0.31.31.90.2-1.41.4
Intermitt. access day 15 inactive lever presses1.83.64.71.3-2.12.2
Intermitt. access escalation Index0.81.11.60.01.2-1.3
Intermittent access day 1 total infusions0.10.10.30.5-0.20.2
Intermittent access day 15 total infusions1.32.02.21.5-1.31.4
Intermittent access terminal intake (last 3 days)0.60.81.31.2-0.80.8
Intermittent access total infusions1.11.31.71.3-1.01.0
Intermittent access day 1 locomotion0.30.40.6-0.40.7-0.8
Intermittent access day 15 total locomotion0.20.30.90.9-0.10.1
Intermittent access total locomotion0.30.41.11.00.3-0.3
Intermittent access standard deviation1.73.65.5-0.0-2.32.4
Left kidney weight0.31.42.6-1.61.0-0.8
Right kidney weight0.20.91.0-1.01.0-0.9
Cocaine induced anxiety0.20.30.7-0.8-0.30.4
Post-drug Anxiety0.00.00.1-0.3-0.10.1
Baseline Anxiety0.30.30.60.70.5-0.5
Tail length1.97.619.5-4.41.2-1.3
Length with tail2.812.035.8-6.00.4-0.2
Length without tail2.06.519.3-4.4-0.20.5
Times rat made contact with spout0.30.30.7-0.9-0.40.4
Lifetime Intake0.81.02.31.5-0.60.6
Liver weight, left0.50.70.8-0.80.8-0.9
Liver weight, right1.22.23.0-1.71.3-1.4
Locomotor activity2.43.79.7-3.10.8-0.8
Locomotor testing distance1.52.77.1-2.70.7-0.6
Locomotor testing rearing0.00.10.2-0.0-0.40.3
Locomotion in novel chamber0.70.81.30.2-1.11.1
Locomotion in novel chamber post-restriction0.40.70.9-0.60.9-1.0
Fecal boli incidents, locomotor time 10.20.30.7-0.8-0.30.3
Change in fecal boli incidents, locomotor task0.10.10.10.30.3-0.3
Time >=10cm from walls, locomotor time 10.50.60.70.60.8-0.8
Bouts of movement, locomotor time 10.00.00.0-0.2-0.10.1
Total resting periods, locomotor time 10.00.00.0-0.1-0.10.1
Rest time, locomotor task time 10.30.41.01.00.1-0.1
Distance moved, locomotor task time 10.50.81.6-1.3-0.60.6
Vertical activity count, locomotor time 10.10.31.0-1.0-0.10.1
Time >=10cm from walls, locomotor time 20.30.41.0-1.00.4-0.4
Bouts of movement, locomotor time 20.40.60.90.1-0.90.9
Total resting periods, locomotor time 20.20.40.60.3-0.70.8
Rest time, locomotor task time 20.10.10.20.30.4-0.4
Distance moved, locomotor task time 20.40.51.0-1.0-0.50.5
Vertical activity count, locomotor time 20.00.00.0-0.2-0.10.1
Light reinforcement 10.30.71.5-1.20.6-0.5
Light reinforcement 21.21.93.10.41.8-1.6
Bone: marrow area0.40.81.2-0.31.0-1.1
Bone: maximum diameter0.81.42.10.6-1.31.4
Bone: maximum force0.20.41.2-1.1-0.10.2
Bone: maximum moment0.30.51.4-1.2-0.20.3
Mean time between licks in bursts0.30.82.01.4-0.50.5
Mean num. licks in bursts1.62.53.2-1.11.8-1.8
Cd content in liver0.30.30.50.10.6-0.7
Co content in liver1.21.41.80.9-1.31.3
Cu content in liver1.92.25.8-2.40.7-0.7
Fe content in liver0.81.01.9-1.4-0.80.7
K content in liver0.70.60.8-0.90.8-0.6
Mg content in liver0.30.30.60.20.8-0.4
Mn content in liver1.41.62.4-0.61.6-1.4
Na content in liver0.50.61.5-1.20.2-0.4
Rb content in liver1.11.32.3-0.6-1.51.1
Se content in liver0.20.20.3-0.50.5-0.3
Sr content in liver1.10.91.9-0.21.4-0.9
Zn content in liver1.82.03.6-1.91.2-1.1
Bone: minimum diameter0.20.40.91.0-0.30.4
Time in familiar zone, hab. session 12.12.02.61.3-1.61.3
Time in novel zone, hab. session 10.50.50.9-1.00.6-0.5
Total zone transitions, hab. session 11.62.33.3-1.11.8-1.5
Total locomotion distance, hab. session 10.60.81.2-0.71.1-0.9
Locomotion velocity, hab. session 10.91.31.9-0.71.4-1.2
Time in familiar zone, hab. session 21.51.62.20.7-1.51.5
Time in novel zone, hab. session 20.40.40.7-0.10.7-0.9
Total zone transitions, hab. session 20.30.40.8-0.40.9-0.5
Total locomotion distance, hab. session 20.70.91.2-0.71.1-0.9
Locomotion velocity, hab. session 20.71.01.5-0.71.2-1.0
Novel to familiar place preference ratio5.35.88.8-0.92.8-3.0
Novelty place preference5.96.39.7-0.92.9-3.1
Time in novel zone, NPP test5.05.48.2-1.02.6-2.9
Total zone transitions, NPP test4.15.87.8-2.12.8-2.3
Total locomotion distance, NPP test1.21.61.9-1.41.3-1.0
Locomotion velocity, NPP test1.62.32.8-1.51.7-1.4
Intraocular pressure0.40.51.0-1.00.2-0.7
Delta distance traveled before/after self-admin0.40.40.5-0.40.7-0.7
Delta ambulatory time before/after self-admin0.81.01.3-1.10.9-0.9
Parametrial fat weight0.30.71.9-1.40.5-0.3
Pavlov. Cond. lever latency1.92.45.9-2.40.7-1.0
Pavlov. Cond. magazine entry latency3.64.69.53.1-1.41.5
Pavlov. Cond. change in total contacts1.51.61.71.3-1.31.2
Pavlov. Cond. index score3.74.78.22.9-1.61.8
Pavlov. Cond. latency score3.14.08.12.8-1.31.5
Pavlov. Cond. lever contacts1.21.43.11.8-0.60.9
Pavlov. Cond. magazine entry number4.35.59.7-3.11.8-1.9
Pavlov. Cond. intertrial magazine entries0.30.30.5-0.70.4-0.5
Pavlov. Cond. lever-magazine prob. diff.3.84.77.12.7-1.82.0
Pavlov. Cond. response bias3.94.98.72.9-1.61.8
Pavlov. Cond. lever latency0.30.40.70.8-0.60.3
Pavlov. Cond. magazine entry latency0.10.10.10.30.3-0.1
Pavlov. Cond. change in total contacts0.81.33.8-2.00.2-0.0
Pavlov. Cond. index score0.10.10.3-0.50.30.0
Pavlov. Cond. latency score0.10.10.1-0.40.3-0.0
Pavlov. Cond. lever contacts0.50.81.1-1.00.8-0.7
Pavlov. Cond. magazine entry number0.10.10.1-0.4-0.30.1
Pavlov. Cond. intertrial magazine entries0.71.11.51.0-1.20.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.40.3-0.0
Pavlov. Cond. response bias0.10.10.1-0.20.4-0.1
Time in closed arm before self-admin0.30.31.0-1.0-0.10.1
Time in closed arm after self-admin0.40.50.50.6-0.70.7
Time in open arm before self-admin0.20.30.80.9-0.00.0
Time in open arm after self-admin1.61.82.70.41.6-1.6
Bone: periosteal estimation0.00.00.1-0.1-0.20.3
Bone: periosteal perimeter0.40.61.31.2-0.50.5
Bone: post-yield work0.20.30.4-0.00.7-0.6
Progressive ratio test 1 active lever presses0.40.60.80.00.9-0.9
Progressive ratio test 1 breakpoint0.50.61.00.01.0-1.0
Progressive ratio test 1 inactive lever presses0.91.31.70.7-1.31.3
Progressive ratio test 2 active lever presses0.81.01.71.3-0.70.8
Progressive ratio test 2 breakpoint0.91.01.71.3-0.80.8
Progressive ratio test 2 inactive lever presses3.35.36.81.7-2.52.6
Incentive Sensitization - Responses1.72.42.41.6-1.51.6
Incentive Sensitization - Breakpoint1.92.52.61.6-1.61.6
Sum of active levers in priming session hrs 5-61.51.42.1-0.31.4-1.5
Progressive ratio1.82.84.7-2.21.3-1.4
Food seeking constrained by brief footshock0.60.71.91.4-0.30.4
Seeking ratio, punishment vs. effort3.04.37.92.8-1.51.6
Retroperitoneal fat weight0.52.15.9-2.40.6-0.5
Reaction time number correct0.30.50.90.9-0.70.6
Reaction time mean minus median0.10.40.6-0.40.8-0.6
Reaction time mean minus median AUC0.30.81.1-0.61.0-1.0
Reaction time num false alarms0.10.10.20.5-0.20.1
Reaction time num false alarms AUC0.00.10.10.20.2-0.4
Reaction time trials correct on left0.30.50.90.9-0.70.6
Reaction time trials on left0.30.50.90.9-0.60.5
Reaction time mean0.10.20.4-0.10.6-0.6
Reaction time mean AUC0.30.50.8-0.00.8-0.9
Median of all reaction times0.10.20.30.10.4-0.5
Reaction time omissions0.10.20.40.30.2-0.6
Reaction time false alarm rate0.00.00.1-0.10.1-0.3
Reaction time premature initiation rate1.11.53.8-2.00.6-0.5
Reaction time premature initiations0.40.61.8-1.40.2-0.1
Std. dev. reaction times0.61.11.5-0.51.2-1.2
Reaction time trials completed0.30.50.90.9-0.60.5
Reaction time trials AUC0.30.61.11.1-0.70.6
Run reversals in cocaine runway, females1.51.52.41.5-1.01.0
Run reversals in cocaine runway, males1.21.21.5-1.2-1.01.0
Latency to leave start box in cocaine runway0.20.20.5-0.7-0.20.2
Latency to leave start box in cocaine runway, F1.41.62.0-1.0-1.41.4
Latency to leave start box in cocaine runway, M0.60.50.70.50.8-0.8
Std. dev. time between licks in bursts4.35.96.62.6-2.32.4
Total sessions with >9 infusions0.91.01.30.8-1.11.1
Short access day 1 total inactive lever presses2.12.76.92.6-0.80.8
Short access day 10 total inactive lever presses1.43.45.2-0.5-2.22.3
Short access day 1 total infusions1.11.54.12.0-0.40.4
Short access day 10 total infusions0.81.03.11.8-0.10.1
Short access total infusions1.31.75.02.2-0.10.1
Short access day 1 locomotion0.40.50.60.7-0.70.7
Short access day 10 total locomotion0.10.20.4-0.00.6-0.6
Short access total locomotion0.20.30.40.10.6-0.6
One hour access (0.3 mA shock)0.40.40.91.00.5-0.5
Compulsive drug intake1.01.21.61.31.0-1.0
One hour access (shock baseline)0.30.50.70.4-0.80.8
Social response proportion0.10.10.2-0.4-0.1-0.1
Social responses0.50.60.7-0.80.7-0.7
Social time1.11.52.20.7-1.31.5
Soleus weight1.44.211.9-3.40.7-0.4
Bone: stiffness0.10.10.4-0.60.1-0.0
Tibialis anterior weight0.20.51.00.0-0.81.0
Time to tail flick, vehicle, before self-admin0.50.51.3-1.20.3-0.3
Time to tail flick, vehicle, after self-admin0.50.70.8-0.9-0.80.8
Time to tail flick, test, before self-admin1.71.72.6-0.31.6-1.6
Time to tail flick, test, after self-admin0.30.30.40.3-0.60.6
Delta time to tail flick, vehicle, before/after SA0.40.40.60.2-0.70.7
Delta time to tail flick, test, before/after SA0.50.50.70.5-0.80.8
Tibia length2.77.618.3-4.31.7-1.2
Ambulatory time before self-admin1.11.71.91.2-1.31.4
Ambulatory time after self-admin0.00.00.10.2-0.00.0
Bone: tissue strength1.21.22.8-1.7-0.60.7
Total heroin consumption1.41.62.2-1.5-1.11.2
Bone: trabecular number1.21.92.11.41.3-1.5
Bone: trabecular spacing1.72.22.9-1.7-1.31.5
Bone: trabecular thickness1.62.03.0-0.01.7-1.7
Bone: trabecular tissue density0.30.40.8-0.90.5-0.5
Water consumed over 24 hours0.81.11.8-0.3-1.21.3
Number of responses in last shaping day2.22.43.60.4-1.91.9