Hub : Genes

Slc26a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Slc26a6	0.02	0.01	6.9e-03	0.01	0	0	0	4.4e-02	1.4e-01	1.3e-01	2.3e-01
2	RMTg	intron excision ratio	chr8_109566450_109568060	0.19	0.12	2.7e-03	0.04	-0.01	-0.01	0.01	2.5e-02	6.7e-01	9.1e-01	1.4e-01
3	IL	intron excision ratio	chr8_109564676_109564848	0.23	0.14	6.4e-03	0.05	0.01	0.01	0.02	2.4e-02	1.5e-01	2.1e-01	1.2e-01
4	IL	intron excision ratio	chr8_109564723_109564848	0.22	0.14	8.8e-03	0.05	0.01	0	0.01	2.8e-02	1.8e-01	3.0e-01	1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.9	1.8	0.0	0.0	1.3	-1.3
Area under the delay curve	0.9	1.0	1.4	-1.2	-1.2	0.8	-0.8
BMI with tail	0.2	0.6	0.7	0.8	0.8	0.7	-0.7
BMI without tail	1.1	2.3	3.2	1.8	1.8	1.2	-1.2
Body weight	2.5	10.4	20.3	4.5	4.5	0.6	-0.6
Weight adjusted by age	0.6	0.7	1.2	0.4	0.4	-1.1	1.1
Bone surface	0.1	0.2	0.2	-0.5	-0.5	0.5	-0.5
Bone volume	0.2	0.3	0.6	-0.3	-0.3	0.8	-0.8
Breakpoint value in progressive ratio session	0.4	0.4	0.4	0.6	0.6	0.7	-0.7
Number of licking bursts	1.5	1.8	3.4	-0.4	-0.4	-1.8	1.8
Context. condit. distance diff. score	0.0	0.1	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 1	0.2	0.2	0.3	-0.3	-0.3	0.5	-0.5
Locomotion distance, session 1	1.3	1.7	2.7	0.8	0.8	1.6	-1.6
Locomotion velocity, session 2	0.2	0.3	0.5	-0.7	-0.7	-0.1	0.1
Locomotion distance, session 2	0.7	1.0	1.9	-0.4	-0.4	1.4	-1.4
Locomotion velocity, session 3	1.2	1.4	2.9	-0.0	-0.0	1.7	-1.7
Locomotion distance, session 3	1.4	1.5	1.9	-1.4	-1.4	1.1	-1.1
Stereotopy head waving bouts, day 3	1.4	1.6	3.1	0.3	0.3	-1.8	1.8
Stereotopy head waving duration, day 3	0.6	0.7	1.1	0.7	0.7	-1.0	1.0
Locomotion velocity, session 7	0.8	0.9	1.8	0.1	0.1	1.3	-1.3
Locomotion distance, session 7	0.9	1.1	1.6	-1.3	-1.3	0.8	-0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.0	0.0	0.4	-0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.7	0.7	0.6	-0.6
Locomotion velocity, session 8	0.9	1.1	2.1	0.2	0.2	1.4	-1.4
Locomotion distance, session 8	1.7	2.5	4.9	0.3	0.3	2.2	-2.2
Degree of sensitization distance	0.7	0.7	1.5	1.2	1.2	-0.1	0.1
Degree of sensitization stereotypy	0.5	0.6	1.1	0.3	0.3	1.0	-1.0
Conditioned locomotion	1.1	1.3	2.5	-1.6	-1.6	0.2	-0.2
Cocaine response after cond. corrected	1.4	1.6	2.7	0.7	0.7	-1.6	1.6
Cocaine response after cond. not corrected	1.4	1.5	2.2	1.5	1.5	-0.9	0.9
Cocaine response before conditioning	1.3	1.6	2.4	0.9	0.9	1.5	-1.5
Saline control response	2.0	2.6	3.0	1.5	1.5	1.7	-1.7
Bone: connectivity density	0.7	1.1	2.0	-0.5	-0.5	1.4	-1.4
Bone: cortical apparent density	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.2
Bone: cortical area	1.5	2.2	4.0	-0.6	-0.6	-2.0	2.0
Bone: cortical porosity	0.6	0.7	1.4	-0.1	-0.1	1.2	-1.2
Bone: cortical porosity	0.7	0.8	1.4	-0.3	-0.3	1.2	-1.2
Bone: cortical thickness	1.5	2.4	4.8	0.2	0.2	-2.2	2.2
Bone: cortical thickness	0.1	0.1	0.2	0.0	0.0	-0.4	0.4
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.0	0.0	-1.1	1.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.1	0.3	0.3	-1.5	1.5
Condit. Reinf. active responses	0.3	0.4	0.8	-0.1	-0.1	-0.9	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.5	-0.5	0.1	-0.1
Incentive salience index mean	0.2	0.3	0.4	-0.3	-0.3	-0.7	0.7
Condit. Reinf. lever presses	0.6	0.8	1.6	-1.3	-1.3	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.6	0.8	1.5	1.2	1.2	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	1.0	1.0	-0.0	0.0
Condit. Reinf. active responses	0.6	0.8	1.6	1.3	1.3	0.2	-0.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0
Condit. Reinf. lever presses	0.7	1.0	1.8	1.3	1.3	0.4	-0.4
Condit. Reinf. lever reinforcers received	0.7	1.0	1.9	1.4	1.4	0.2	-0.2
Conditioned reinforcement - actives	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.2
Conditioned reinforcement - inactives	3.0	3.4	5.7	-1.0	-1.0	-2.4	2.4
Conditioned locomotion	0.3	0.4	0.7	-0.3	-0.3	0.8	-0.8
Patch foraging indifference point 0 sec	1.3	2.0	2.1	1.4	1.4	1.5	-1.5
Patch foraging indifference point AUC	1.0	1.2	2.2	0.4	0.4	1.5	-1.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.2	0.2	0.3	-0.3
Delay disc. indifference point, 16s delay	0.5	0.5	0.7	-0.8	-0.8	0.5	-0.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.5	-0.5	0.3	-0.3
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	-1.0	-1.0	0.5	-0.5
Delay disc. indifference point, 4s delay	0.5	0.6	1.1	-1.1	-1.1	0.0	-0.0
Delay disc. indifference point, 8s delay	1.2	1.2	1.9	-1.4	-1.4	0.7	-0.7
Indifference point function ln k	0.4	0.5	1.0	-1.0	-1.0	0.1	-0.1
Indifference point function log k	0.4	0.5	1.0	-1.0	-1.0	0.1	-0.1
Patch foraging total patch changes 0 sec	1.1	1.7	2.3	1.5	1.5	1.0	-1.0
Patch foraging total patch changes 12 sec	0.7	0.9	1.4	1.2	1.2	0.6	-0.6
Patch foraging total patch changes 18 sec	1.7	2.1	2.9	1.7	1.7	1.2	-1.2
Patch foraging total patch changes 24 sec	1.3	1.6	3.0	1.7	1.7	0.5	-0.5
Patch foraging total patch changes 6 sec	1.0	1.6	2.7	0.6	0.6	1.6	-1.6
Patch foraging time to switch 0 sec	0.8	1.2	2.2	-0.4	-0.4	-1.5	1.5
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.5	0.5	0.0	-0.0
Patch foraging water rate 12 sec	0.1	0.1	0.1	0.4	0.4	0.2	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.1	0.1	-0.6	0.6
Patch foraging water rate 24 sec	0.4	0.5	1.1	1.0	1.0	-0.1	0.1
Patch foraging water rate 6 sec	0.3	0.4	0.4	0.6	0.6	0.7	-0.7
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.2	-1.5	-1.5	0.6	-0.6
Distance traveled before self-admin	1.1	1.2	1.4	-0.9	-0.9	-1.2	1.2
Distance traveled after self-admin	1.1	1.2	1.9	-1.4	-1.4	-0.7	0.7
Extensor digitorum longus weight	0.3	1.0	1.4	-0.8	-0.8	-1.2	1.2
Bone: elastic displacement	0.5	0.6	1.1	0.1	0.1	-1.0	1.0
Bone: elastic work	0.3	0.3	0.4	0.5	0.5	-0.7	0.7
Bone: endosteal estimation	0.1	0.3	0.6	0.2	0.2	0.8	-0.8
Bone: endosteal perimeter	0.6	1.3	2.6	-1.6	-1.6	-0.0	0.0
Epididymis fat weight	0.0	0.1	0.1	0.3	0.3	0.0	-0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.0	-0.0	0.3	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	0.1	0.4	-0.4
Diff in mean of infusions in LGA sessions	1.6	1.8	3.2	0.6	0.6	-1.8	1.8
Delay discount exponential model param	1.0	1.0	1.8	1.3	1.3	-0.6	0.6
Extinction: sum of active levers before priming	0.4	0.4	0.8	0.1	0.1	0.9	-0.9
Active lever presses in extinction session 6	1.0	0.9	1.9	0.1	0.1	1.4	-1.4
Bone: final force	0.6	0.9	1.0	1.0	1.0	-1.0	1.0
Bone: final moment	0.8	1.2	1.3	1.1	1.1	-1.1	1.1
Food consumed during 24 hour testing period	0.6	0.7	1.3	1.2	1.2	0.1	-0.1
Glucose	0.8	1.2	2.1	0.6	0.6	1.5	-1.5
Heart weight	1.8	2.5	3.5	1.9	1.9	-1.2	1.2
Delay discount hyperbolic model param	1.0	1.0	1.7	1.3	1.3	-0.6	0.6
Intermittent access intake day 1-15 change	3.0	2.9	4.3	-1.3	-1.3	-2.1	2.1
Intermittent access intake escalation	2.5	2.5	3.3	-1.3	-1.3	-1.8	1.8
Intermittent access intake escalation 2	2.3	2.3	3.7	-0.9	-0.9	-1.9	1.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.3	0.3
Intermitt. access day 15 inactive lever presses	1.6	1.8	2.6	-1.0	-1.0	-1.6	1.6
Intermitt. access escalation Index	0.5	0.5	0.9	0.1	0.1	1.0	-1.0
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	0.1	0.0	-0.0
Intermittent access day 15 total infusions	0.9	1.0	1.1	-0.9	-0.9	-1.1	1.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7
Intermittent access total infusions	0.5	0.5	0.6	-0.8	-0.8	-0.6	0.6
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2
Intermittent access day 15 total locomotion	0.8	0.8	1.4	-1.2	-1.2	0.5	-0.5
Intermittent access total locomotion	0.8	1.0	1.6	-1.3	-1.3	0.6	-0.6
Intermittent access standard deviation	2.7	2.9	5.4	-0.6	-0.6	-2.3	2.3
Left kidney weight	1.4	3.9	6.2	1.3	1.3	2.5	-2.5
Right kidney weight	1.1	3.0	5.8	0.5	0.5	2.4	-2.4
Cocaine induced anxiety	0.4	0.5	0.9	0.1	0.1	-1.0	1.0
Post-drug Anxiety	0.2	0.2	0.3	0.3	0.3	-0.6	0.6
Baseline Anxiety	0.5	0.5	1.1	-1.0	-1.0	0.1	-0.1
Tail length	3.5	10.7	20.3	4.5	4.5	1.0	-1.0
Length with tail	4.1	15.2	29.7	5.5	5.5	0.8	-0.8
Length without tail	2.4	5.2	10.4	3.2	3.2	-0.0	0.0
Times rat made contact with spout	0.4	0.5	0.8	0.9	0.9	-0.4	0.4
Lifetime Intake	0.3	0.3	0.6	-0.8	-0.8	-0.3	0.3
Liver weight, left	0.5	0.8	1.3	0.6	0.6	1.1	-1.1
Liver weight, right	1.7	2.8	3.0	1.6	1.6	1.7	-1.7
Locomotor activity	3.1	5.0	9.3	3.1	3.1	0.8	-0.8
Locomotor testing distance	2.7	4.4	7.8	2.8	2.8	1.0	-1.0
Locomotor testing rearing	0.1	0.1	0.2	0.5	0.5	-0.3	0.3
Locomotion in novel chamber	0.4	0.5	0.7	-0.5	-0.5	-0.8	0.8
Locomotion in novel chamber post-restriction	0.6	0.7	1.0	0.6	0.6	1.0	-1.0
Fecal boli incidents, locomotor time 1	0.4	0.5	0.9	1.0	1.0	-0.2	0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.0	-0.0	0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.8	-0.9	-0.9	0.8	-0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	0.5	-0.1	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.4	0.4	-0.1	0.1
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.5	-0.5	0.2	-0.2
Distance moved, locomotor task time 1	0.6	0.6	0.9	1.0	1.0	-0.5	0.5
Vertical activity count, locomotor time 1	0.4	0.4	0.8	0.9	0.9	-0.0	0.0
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.1	1.0	1.0	0.4	-0.4
Bouts of movement, locomotor time 2	0.3	0.4	0.6	-0.3	-0.3	-0.8	0.8
Total resting periods, locomotor time 2	0.3	0.4	0.5	-0.5	-0.5	-0.7	0.7
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	0.4	0.4	-0.4
Distance moved, locomotor task time 2	0.2	0.2	0.2	0.4	0.4	-0.5	0.5
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1
Light reinforcement 1	0.4	0.7	1.3	1.1	1.1	0.5	-0.5
Light reinforcement 2	0.9	1.1	2.1	-0.4	-0.4	1.5	-1.5
Bone: marrow area	0.2	0.4	0.7	0.3	0.3	0.8	-0.8
Bone: maximum diameter	0.8	1.5	2.3	-0.8	-0.8	-1.5	1.5
Bone: maximum force	0.3	0.5	0.8	0.9	0.9	-0.5	0.5
Bone: maximum moment	0.4	0.6	0.9	1.0	1.0	-0.6	0.6
Mean time between licks in bursts	0.8	1.2	2.2	-1.5	-1.5	-0.4	0.4
Mean num. licks in bursts	1.7	2.0	3.1	1.0	1.0	1.8	-1.8
Cd content in liver	2.0	2.2	3.2	1.8	1.8	-1.1	1.1
Co content in liver	0.5	0.6	1.1	-0.3	-0.3	-1.0	1.0
Cu content in liver	3.0	3.6	6.2	2.5	2.5	1.0	-1.0
Fe content in liver	1.7	2.1	3.0	1.7	1.7	-1.1	1.1
K content in liver	1.3	1.3	1.4	1.1	1.1	1.2	-1.2
Mg content in liver	0.5	0.5	0.9	0.1	0.1	1.0	-1.0
Mn content in liver	1.4	1.6	2.9	0.5	0.5	1.7	-1.7
Na content in liver	0.4	0.4	0.7	0.8	0.8	0.4	-0.4
Rb content in liver	1.8	2.2	2.8	1.3	1.3	-1.7	1.7
Se content in liver	0.1	0.2	0.2	0.4	0.4	0.4	-0.4
Sr content in liver	0.4	0.3	0.7	-0.1	-0.1	0.8	-0.8
Zn content in liver	3.1	3.4	5.6	2.4	2.4	1.1	-1.1
Bone: minimum diameter	0.4	0.7	1.1	-1.1	-1.1	-0.5	0.5
Time in familiar zone, hab. session 1	1.6	1.5	2.3	-0.9	-0.9	-1.5	1.5
Time in novel zone, hab. session 1	0.3	0.3	0.3	0.6	0.6	0.5	-0.5
Total zone transitions, hab. session 1	1.2	1.7	3.2	0.5	0.5	1.8	-1.8
Total locomotion distance, hab. session 1	0.4	0.6	1.0	0.6	0.6	1.0	-1.0
Locomotion velocity, hab. session 1	0.7	1.0	1.6	0.6	0.6	1.3	-1.3
Time in familiar zone, hab. session 2	1.2	1.3	2.1	-0.7	-0.7	-1.4	1.4
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.0	0.0	0.7	-0.7
Total zone transitions, hab. session 2	0.4	0.5	1.0	-0.1	-0.1	1.0	-1.0
Total locomotion distance, hab. session 2	0.7	0.9	1.2	0.7	0.7	1.1	-1.1
Locomotion velocity, hab. session 2	0.7	1.0	1.5	0.6	0.6	1.2	-1.2
Novel to familiar place preference ratio	3.6	3.7	6.7	0.8	0.8	2.6	-2.6
Novelty place preference	3.9	4.0	7.3	0.8	0.8	2.7	-2.7
Time in novel zone, NPP test	3.3	3.4	5.9	0.9	0.9	2.4	-2.4
Total zone transitions, NPP test	3.4	4.9	7.8	1.4	1.4	2.8	-2.8
Total locomotion distance, NPP test	1.0	1.4	1.4	1.2	1.2	1.2	-1.2
Locomotion velocity, NPP test	1.4	1.9	2.4	1.2	1.2	1.5	-1.5
Intraocular pressure	1.0	1.4	2.8	1.7	1.7	0.3	-0.3
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.3	-0.3	0.5	-0.5
Delta ambulatory time before/after self-admin	0.4	0.5	0.6	0.6	0.6	0.8	-0.8
Parametrial fat weight	0.8	1.6	2.1	1.4	1.4	1.1	-1.1
Pavlov. Cond. lever latency	2.7	3.4	6.3	2.5	2.5	0.8	-0.8
Pavlov. Cond. magazine entry latency	4.2	5.5	8.1	-2.8	-2.8	-1.7	1.7
Pavlov. Cond. change in total contacts	1.5	1.7	1.7	-1.3	-1.3	-1.3	1.3
Pavlov. Cond. index score	4.1	5.2	7.6	-2.8	-2.8	-1.7	1.7
Pavlov. Cond. latency score	3.8	4.8	7.8	-2.8	-2.8	-1.3	1.3
Pavlov. Cond. lever contacts	1.5	1.7	3.1	-1.8	-1.8	-0.6	0.6
Pavlov. Cond. magazine entry number	4.5	5.6	8.4	2.9	2.9	1.7	-1.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.6	0.6	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.2	6.6	-2.6	-2.6	-2.0	2.0
Pavlov. Cond. response bias	4.6	5.6	7.8	-2.8	-2.8	-1.8	1.8
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.4	-0.4	-0.3	0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.1
Pavlov. Cond. change in total contacts	0.8	1.1	2.1	1.5	1.5	0.1	-0.1
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Pavlov. Cond. lever contacts	0.4	0.6	0.7	0.8	0.8	0.7	-0.7
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	0.8	0.8	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1
Time in closed arm before self-admin	0.2	0.2	0.4	0.7	0.7	-0.0	0.0
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	0.2	-0.3	0.3
Time in open arm before self-admin	0.3	0.3	0.6	-0.8	-0.8	-0.3	0.3
Time in open arm after self-admin	1.4	1.5	2.5	-0.7	-0.7	1.6	-1.6
Bone: periosteal estimation	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.4
Bone: periosteal perimeter	0.9	1.6	2.3	-1.5	-1.5	-0.9	0.9
Bone: post-yield work	0.1	0.1	0.2	0.1	0.1	0.4	-0.4
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	-0.1	-0.1	0.9	-0.9
Progressive ratio test 1 breakpoint	0.4	0.4	0.7	-0.1	-0.1	0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.7	0.7	1.2	-0.5	-0.5	-1.1	1.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.0	-1.0	-1.0	-0.4	0.4
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	-0.8	-0.8	-0.5	0.5
Progressive ratio test 2 inactive lever presses	3.3	3.8	5.4	-1.4	-1.4	-2.3	2.3
Incentive Sensitization - Responses	1.2	1.3	1.3	-1.2	-1.2	-1.1	1.1
Incentive Sensitization - Breakpoint	1.2	1.3	1.3	-1.2	-1.2	-1.1	1.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.4	0.4	0.7	-0.7
Progressive ratio	2.0	2.3	3.4	1.8	1.8	1.1	-1.1
Food seeking constrained by brief footshock	1.0	1.2	2.2	-1.5	-1.5	-0.4	0.4
Seeking ratio, punishment vs. effort	3.7	4.6	6.9	-2.6	-2.6	-1.5	1.5
Retroperitoneal fat weight	0.3	1.0	1.2	0.9	0.9	1.1	-1.1
Reaction time number correct	0.6	0.9	1.2	-1.1	-1.1	-0.8	0.8
Reaction time mean minus median	0.3	0.4	0.5	0.5	0.5	0.7	-0.7
Reaction time mean minus median AUC	0.6	0.7	0.8	0.9	0.9	0.8	-0.8
Reaction time num false alarms	0.2	0.3	0.5	-0.7	-0.7	-0.2	0.2
Reaction time num false alarms AUC	0.1	0.1	0.1	-0.4	-0.4	0.2	-0.2
Reaction time trials correct on left	0.6	0.9	1.2	-1.1	-1.1	-0.8	0.8
Reaction time trials on left	0.7	0.9	1.3	-1.1	-1.1	-0.8	0.8
Reaction time mean	0.1	0.1	0.1	-0.2	-0.2	0.4	-0.4
Reaction time mean AUC	0.1	0.2	0.4	-0.2	-0.2	0.6	-0.6
Median of all reaction times	0.1	0.1	0.2	-0.5	-0.5	0.2	-0.2
Reaction time omissions	0.3	0.4	0.4	-0.6	-0.6	-0.6	0.6
Reaction time false alarm rate	0.0	0.0	0.0	0.0	0.0	0.2	-0.2
Reaction time premature initiation rate	0.8	1.1	1.7	1.3	1.3	0.7	-0.7
Reaction time premature initiations	0.1	0.2	0.3	0.6	0.6	0.2	-0.2
Std. dev. reaction times	0.4	0.5	0.9	0.3	0.3	1.0	-1.0
Reaction time trials completed	0.7	0.9	1.3	-1.1	-1.1	-0.8	0.8
Reaction time trials AUC	0.8	1.1	1.6	-1.3	-1.3	-0.8	0.8
Run reversals in cocaine runway, females	1.8	1.7	2.5	-1.6	-1.6	-1.0	1.0
Run reversals in cocaine runway, males	0.6	0.6	0.7	0.7	0.7	-0.8	0.8
Latency to leave start box in cocaine runway	0.6	0.7	1.3	1.1	1.1	-0.0	0.0
Latency to leave start box in cocaine runway, F	1.4	1.5	2.0	1.4	1.4	-1.0	1.0
Latency to leave start box in cocaine runway, M	0.6	0.6	1.2	-0.1	-0.1	1.1	-1.1
Std. dev. time between licks in bursts	4.7	5.6	6.0	-2.4	-2.4	-2.3	2.3
Total sessions with >9 infusions	1.0	1.0	2.0	-0.2	-0.2	-1.4	1.4
Short access day 1 total inactive lever presses	2.8	3.2	4.5	-2.1	-2.1	-1.4	1.4
Short access day 10 total inactive lever presses	1.9	2.1	4.2	0.2	0.2	-2.1	2.1
Short access day 1 total infusions	0.5	0.5	0.6	-0.6	-0.6	-0.7	0.7
Short access day 10 total infusions	0.1	0.2	0.3	-0.6	-0.6	0.1	-0.1
Short access total infusions	0.4	0.5	0.9	-1.0	-1.0	0.1	-0.1
Short access day 1 locomotion	0.1	0.1	0.1	-0.1	-0.1	-0.3	0.3
Short access day 10 total locomotion	0.4	0.4	0.8	-0.1	-0.1	0.9	-0.9
Short access total locomotion	0.5	0.5	1.0	0.2	0.2	1.0	-1.0
One hour access (0.3 mA shock)	0.3	0.4	0.5	-0.7	-0.7	0.5	-0.5
Compulsive drug intake	1.0	1.0	1.9	-0.1	-0.1	1.4	-1.4
One hour access (shock baseline)	0.3	0.4	0.6	-0.4	-0.4	-0.8	0.8
Social response proportion	0.1	0.1	0.2	0.4	0.4	-0.2	0.2
Social responses	0.4	0.5	0.7	0.8	0.8	0.5	-0.5
Social time	1.2	1.6	2.6	-0.8	-0.8	-1.6	1.6
Soleus weight	1.8	5.2	10.0	3.2	3.2	0.6	-0.6
Bone: stiffness	0.0	0.1	0.1	0.3	0.3	-0.1	0.1
Tibialis anterior weight	0.1	0.2	0.4	-0.1	-0.1	-0.6	0.6
Time to tail flick, vehicle, before self-admin	1.2	1.3	2.4	1.6	1.6	0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.3	0.8	0.8	-1.1	1.1
Time to tail flick, test, before self-admin	1.4	1.3	2.5	0.4	0.4	1.6	-1.6
Time to tail flick, test, after self-admin	0.3	0.3	0.6	-0.2	-0.2	-0.7	0.7
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.9	-0.8	-0.8	-1.4	1.4
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	-0.6	-0.6	-1.0	1.0
Tibia length	3.4	9.7	16.1	4.0	4.0	1.8	-1.8
Ambulatory time before self-admin	1.3	1.4	1.4	-1.2	-1.2	-1.2	1.2
Ambulatory time after self-admin	0.7	0.8	1.5	-1.2	-1.2	0.2	-0.2
Bone: tissue strength	1.5	1.4	2.2	1.5	1.5	-0.8	0.8
Total heroin consumption	0.6	0.7	1.0	1.0	1.0	-0.6	0.6
Bone: trabecular number	1.2	1.8	2.3	-1.1	-1.1	1.5	-1.5
Bone: trabecular spacing	1.5	2.0	2.0	1.4	1.4	-1.4	1.4
Bone: trabecular thickness	1.1	1.3	2.6	0.1	0.1	1.6	-1.6
Bone: trabecular tissue density	0.3	0.4	0.5	0.7	0.7	0.6	-0.6
Water consumed over 24 hours	0.6	0.8	1.5	0.0	0.0	-1.2	1.2
Number of responses in last shaping day	0.8	0.8	1.3	-0.6	-0.6	-1.1	1.1