Slc18a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Slc18a2	0.23	0.13	4.8e-03	-0	0.03	-0.01	0.01	3.4e-01	5.6e-02	6.8e-01	1.9e-01
2	pVTA	intron excision ratio	chr1_268400112_268400410	0.14	0.07	3.7e-09	0.13	0.12	0.12	0.12	2.6e-10	6.7e-10	6.7e-10	6.3e-10
3	pVTA	intron excision ratio	chr1_268400112_268400415	0.14	0.07	2.5e-09	0.13	0.12	0.12	0.12	1.9e-10	4.3e-10	3.5e-10	3.4e-10
4	pVTA	gene expression	Slc18a2	0.04	0.03	6.3e-03	0.02	0.01	0	0	1.2e-02	4.1e-02	2.2e-01	1.1e-01
5	Adipose	mRNA stability	Slc18a2	0.05	0.03	2.4e-06	0.04	0.05	0.04	0.04	1.1e-05	2.7e-06	1.5e-05	8.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.7	2.8	3.6	1.7	-1.9	1.9	1.7	1.1
Area under the delay curve	0.8	0.9	1.5	-1.1	-0.5	0.5	-1.2	-1.2
BMI with tail	2.7	9.2	15.9	4.0	-3.7	3.7	0.5	-1.8
BMI without tail	1.8	5.6	13.2	3.6	-2.5	2.5	0.5	-1.5
Body weight	3.4	14.9	26.7	4.3	-5.2	5.2	1.5	-0.6
Weight adjusted by age	0.4	0.7	2.2	1.5	-0.4	0.4	-0.3	-0.9
Bone surface	1.1	2.0	2.9	1.7	-1.4	1.4	1.5	0.9
Bone volume	1.0	1.7	3.1	1.2	-1.8	1.8	0.8	0.2
Breakpoint value in progressive ratio session	1.0	1.2	2.6	-0.9	-1.6	1.6	0.2	0.3
Number of licking bursts	1.4	2.3	3.8	1.4	-1.1	1.1	2.0	1.8
Context. condit. distance diff. score	0.3	0.4	1.0	1.0	0.5	-0.5	0.5	0.2
Locomotion velocity, session 1	0.0	0.0	0.1	-0.0	0.3	-0.3	0.0	0.1
Locomotion distance, session 1	0.8	1.0	2.3	0.1	1.5	-1.5	-0.3	-0.4
Locomotion velocity, session 2	1.1	1.3	3.1	0.2	1.8	-1.8	-0.1	-0.1
Locomotion distance, session 2	0.8	1.2	1.9	1.2	1.4	-1.4	-0.1	-0.8
Locomotion velocity, session 3	0.4	0.5	1.2	0.1	1.1	-1.1	-0.1	-0.1
Locomotion distance, session 3	1.2	1.3	2.7	0.4	1.6	-1.6	-0.5	-0.8
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	-1.0	0.5	-0.5	-0.6	-0.3
Stereotopy head waving duration, day 3	0.2	0.2	0.8	-0.9	-0.1	0.1	-0.0	0.4
Locomotion velocity, session 7	0.4	0.5	1.9	1.4	0.3	-0.3	0.6	0.1
Locomotion distance, session 7	0.6	0.7	1.9	1.4	0.8	-0.8	0.1	-0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1	-0.1
Stereotopy head waving duration, day 7	0.6	0.7	1.4	-1.2	-1.0	1.0	-0.3	0.1
Locomotion velocity, session 8	1.0	1.2	2.2	1.2	0.5	-0.5	1.5	1.4
Locomotion distance, session 8	2.0	2.9	6.4	2.5	1.6	-1.6	1.5	0.8
Degree of sensitization distance	0.6	0.7	1.0	0.7	-1.0	1.0	0.7	0.5
Degree of sensitization stereotypy	0.4	0.5	1.0	0.4	-1.0	1.0	0.4	0.2
Conditioned locomotion	0.2	0.2	0.8	-0.9	-0.1	0.1	-0.4	-0.1
Cocaine response after cond. corrected	3.5	4.2	8.7	-0.9	2.9	-2.9	-1.3	-1.1
Cocaine response after cond. not corrected	2.5	2.9	6.3	-1.0	2.5	-2.5	-0.9	-0.5
Cocaine response before conditioning	1.1	1.4	1.9	0.1	-1.4	1.4	1.1	1.4
Saline control response	0.4	0.5	0.9	-0.1	1.0	-1.0	-0.6	-0.7
Bone: connectivity density	1.1	1.7	2.5	1.4	-1.1	1.1	1.6	1.2
Bone: cortical apparent density	2.5	3.4	7.0	-1.0	2.7	-2.7	-1.1	-0.8
Bone: cortical area	2.4	3.8	8.0	2.8	-2.0	2.0	1.6	0.6
Bone: cortical porosity	0.2	0.3	0.6	-0.2	-0.8	0.8	0.2	0.3
Bone: cortical porosity	0.9	1.0	2.0	0.3	-1.4	1.4	0.6	0.6
Bone: cortical thickness	1.7	2.9	11.6	3.4	-0.6	0.6	1.4	0.1
Bone: cortical thickness	0.6	0.7	2.2	1.5	0.0	-0.0	-0.3	-1.1
Bone: cortical tissue density	2.5	3.4	7.0	-1.1	2.6	-2.6	-1.1	-0.7
Condit. Reinf. active minus inactive responses	0.6	0.7	1.3	1.2	0.3	-0.3	1.1	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	0.2	0.2	-0.2	0.9	1.0
Condit. Reinf. active responses	1.6	2.0	6.5	2.5	-0.3	0.3	1.6	0.9
Condit. Reinf. inactive responses	2.0	2.4	8.1	2.9	-0.8	0.8	1.5	0.6
Incentive salience index mean	0.7	0.8	2.3	1.5	0.7	-0.7	0.8	0.4
Condit. Reinf. lever presses	0.3	0.5	1.2	1.1	0.7	-0.7	0.2	-0.3
Condit. Reinf. active minus inactive responses	1.1	1.5	3.0	0.1	-1.7	1.7	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.2	0.2	-1.1	1.1	0.4	0.3
Condit. Reinf. active responses	1.7	2.4	5.1	0.4	-2.3	2.3	1.0	0.9
Condit. Reinf. inactive responses	0.7	1.0	2.1	0.2	-1.5	1.5	0.5	0.5
Condit. Reinf. lever presses	0.6	0.8	1.7	0.6	-1.3	1.3	0.6	0.3
Condit. Reinf. lever reinforcers received	1.5	2.1	3.7	0.5	-1.9	1.9	1.2	1.1
Conditioned reinforcement - actives	0.7	1.2	2.4	-0.7	1.5	-1.5	-0.6	-0.6
Conditioned reinforcement - inactives	0.3	0.5	1.0	-1.0	-0.7	0.7	0.3	0.6
Conditioned locomotion	1.3	1.7	3.8	-0.4	2.0	-2.0	-0.7	-0.6
Patch foraging indifference point 0 sec	0.8	1.4	4.2	2.1	-1.1	1.1	0.7	-0.3
Patch foraging indifference point AUC	0.3	0.4	1.0	0.3	-1.0	1.0	0.4	0.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.2	0.5	-0.5	-0.7	-0.9
Delay disc. indifference point, 16s delay	0.7	0.7	1.3	-0.9	-0.5	0.5	-1.0	-1.1
Delay disc. indifference point, 2s delay	1.7	1.9	3.5	-1.5	0.8	-0.8	-1.9	-1.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.3	-0.8	0.8	-0.2	-0.4
Delay disc. indifference point, 4s delay	0.9	0.9	1.5	-1.2	-0.4	0.4	-1.2	-1.1
Delay disc. indifference point, 8s delay	0.6	0.7	1.3	-1.1	-0.4	0.4	-1.0	-1.0
Indifference point function ln k	0.1	0.2	0.5	0.7	0.6	-0.6	0.2	-0.0
Indifference point function log k	0.1	0.2	0.5	0.7	0.6	-0.6	0.2	-0.0
Patch foraging total patch changes 0 sec	0.9	1.8	5.0	2.2	-1.3	1.3	0.8	-0.2
Patch foraging total patch changes 12 sec	1.1	1.5	3.2	1.8	-1.3	1.3	0.9	0.1
Patch foraging total patch changes 18 sec	1.0	1.6	3.4	0.8	-1.8	1.8	0.6	0.2
Patch foraging total patch changes 24 sec	0.7	1.3	2.3	0.9	-1.5	1.5	0.9	0.6
Patch foraging total patch changes 6 sec	1.7	2.6	5.1	2.3	-1.7	1.7	1.3	0.6
Patch foraging time to switch 0 sec	0.6	1.2	4.5	-2.1	0.6	-0.6	-0.9	0.1
Patch foraging water rate 0 sec	0.7	1.5	5.6	2.4	-0.8	0.8	0.7	-0.3
Patch foraging water rate 12 sec	0.8	1.7	3.7	1.9	-1.2	1.2	1.2	0.4
Patch foraging water rate 18 sec	0.4	0.6	1.2	1.1	0.6	-0.6	-0.3	-1.0
Patch foraging water rate 24 sec	0.5	0.8	2.2	0.8	0.4	-0.4	-0.9	-1.5
Patch foraging water rate 6 sec	0.2	0.3	0.8	0.9	0.1	-0.1	-0.4	-0.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.7	-0.2	1.3	-1.3	0.3	0.6
Distance traveled before self-admin	4.0	5.3	8.0	-1.1	2.8	-2.8	-2.2	-2.1
Distance traveled after self-admin	2.4	2.9	3.4	-1.6	1.8	-1.8	-1.7	-1.5
Extensor digitorum longus weight	0.4	1.6	3.4	0.5	-1.8	1.8	-0.3	-0.9
Bone: elastic displacement	0.7	0.8	1.5	-0.9	0.4	-0.4	-1.2	-1.1
Bone: elastic work	1.2	1.5	3.5	0.0	1.0	-1.0	-1.4	-1.9
Bone: endosteal estimation	0.3	0.7	1.5	0.3	-1.2	1.2	0.5	0.3
Bone: endosteal perimeter	0.4	0.9	2.0	-0.5	-1.4	1.4	-0.4	-0.5
Epididymis fat weight	6.3	21.5	43.6	3.9	-6.6	6.6	2.2	0.5
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	0.5	0.9	-0.9	-0.2	-0.1
Delta time in open arm before/after self-admin	3.0	3.0	4.9	-0.4	-2.2	2.2	1.4	1.8
Diff in mean of infusions in LGA sessions	0.4	0.5	1.1	-0.6	-1.0	1.0	0.3	0.3
Delay discount exponential model param	1.0	1.1	1.8	1.3	0.5	-0.5	1.3	1.3
Extinction: sum of active levers before priming	0.7	0.7	1.3	-0.9	-1.1	1.1	-0.5	-0.4
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.4	-0.4
Bone: final force	1.3	2.1	7.3	2.7	-0.9	0.9	1.2	0.1
Bone: final moment	1.2	1.9	6.3	2.5	-1.0	1.0	1.2	0.1
Food consumed during 24 hour testing period	0.2	0.3	0.4	0.5	0.4	-0.4	0.7	0.5
Glucose	0.8	1.2	3.0	-0.0	-1.7	1.7	-0.2	-0.4
Heart weight	2.1	3.2	8.0	2.8	-1.7	1.7	1.5	0.5
Delay discount hyperbolic model param	1.2	1.3	2.2	1.5	0.4	-0.4	1.5	1.4
Intermittent access intake day 1-15 change	0.5	1.0	2.0	-1.4	0.6	-0.6	-1.3	-0.9
Intermittent access intake escalation	0.3	0.6	1.5	-1.2	0.3	-0.3	-1.0	-0.5
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.6	0.4	-0.4	-0.6	-0.3
Intermitt. access day 1 inactive lever presses	0.7	2.8	5.0	-0.5	-2.2	2.2	1.2	1.5
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.8	0.0	-0.9	0.9	0.2	0.2
Intermitt. access escalation Index	0.1	0.2	0.4	-0.6	-0.3	0.3	0.2	0.6
Intermittent access day 1 total infusions	0.2	0.3	0.6	-0.8	0.3	-0.3	-0.5	-0.4
Intermittent access day 15 total infusions	0.7	1.0	3.0	-1.7	0.4	-0.4	-1.2	-0.7
Intermittent access terminal intake (last 3 days)	0.6	0.7	2.2	-1.5	0.2	-0.2	-1.0	-0.6
Intermittent access total infusions	0.3	0.3	0.9	-1.0	0.2	-0.2	-0.6	-0.4
Intermittent access day 1 locomotion	1.9	2.4	3.3	-1.5	1.3	-1.3	-1.8	-1.6
Intermittent access day 15 total locomotion	0.3	0.6	1.3	-1.1	-0.7	0.7	-0.7	-0.5
Intermittent access total locomotion	1.5	1.7	2.5	-1.1	1.1	-1.1	-1.6	-1.5
Intermittent access standard deviation	0.5	1.0	3.0	-1.7	-0.6	0.6	-1.0	-0.6
Left kidney weight	0.9	4.1	17.1	4.1	-0.7	0.7	0.6	-1.4
Right kidney weight	0.8	3.6	13.3	3.6	-0.5	0.5	-0.2	-2.0
Cocaine induced anxiety	0.9	1.3	2.9	0.6	1.7	-1.7	0.2	0.0
Post-drug Anxiety	1.0	1.1	3.2	1.8	0.0	-0.0	1.2	0.9
Baseline Anxiety	2.0	2.3	4.6	0.6	-2.1	2.1	1.0	1.0
Tail length	0.1	0.6	1.3	-0.4	-1.1	1.1	0.1	0.2
Length with tail	0.7	3.0	5.7	1.3	-2.4	2.4	1.1	0.7
Length without tail	1.8	5.8	10.5	1.9	-3.2	3.2	1.8	1.2
Times rat made contact with spout	0.0	0.1	0.2	0.5	-0.1	0.1	0.1	-0.1
Lifetime Intake	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4	-0.2
Liver weight, left	1.5	2.5	4.0	2.0	-2.0	2.0	0.5	-0.6
Liver weight, right	0.4	0.8	1.8	1.3	-0.2	0.2	-0.5	-1.3
Locomotor activity	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.5	-0.2
Locomotor testing distance	0.6	1.2	1.8	-0.6	1.3	-1.3	-1.1	-0.9
Locomotor testing rearing	0.8	1.6	2.6	-1.3	0.8	-0.8	-1.6	-1.4
Locomotion in novel chamber	0.7	0.8	1.7	0.5	1.3	-1.3	-0.4	-0.6
Locomotion in novel chamber post-restriction	1.0	1.6	2.7	0.3	1.7	-1.7	-0.8	-1.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	0.6	0.1	-0.1	0.5	0.3
Change in fecal boli incidents, locomotor task	0.5	0.4	1.5	1.2	-0.2	0.2	0.7	0.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.6	-0.1	0.1	0.6	0.5
Bouts of movement, locomotor time 1	0.5	0.6	1.3	-1.1	-0.9	0.9	-0.1	0.1
Total resting periods, locomotor time 1	0.3	0.3	0.8	-0.9	-0.6	0.6	-0.2	-0.1
Rest time, locomotor task time 1	0.3	0.4	1.1	1.0	0.6	-0.6	0.1	-0.5
Distance moved, locomotor task time 1	0.2	0.3	0.8	-0.9	-0.2	0.2	-0.7	-0.3
Vertical activity count, locomotor time 1	0.1	0.3	0.7	-0.4	0.3	-0.3	-0.9	-0.7
Time >=10cm from walls, locomotor time 2	0.8	1.1	4.6	2.1	-0.2	0.2	0.9	0.4
Bouts of movement, locomotor time 2	0.8	1.2	5.1	-2.3	0.1	-0.1	-0.9	-0.4
Total resting periods, locomotor time 2	0.9	1.5	6.0	-2.4	0.1	-0.1	-1.1	-0.6
Rest time, locomotor task time 2	0.4	0.5	1.0	-0.9	0.3	-0.3	-1.0	-0.8
Distance moved, locomotor task time 2	0.3	0.3	1.2	1.1	-0.0	0.0	0.6	0.3
Vertical activity count, locomotor time 2	0.3	0.4	1.6	1.2	0.1	-0.1	0.7	0.4
Light reinforcement 1	0.3	0.7	1.4	0.5	1.2	-1.2	-0.3	-0.6
Light reinforcement 2	0.4	0.6	1.5	0.3	1.2	-1.2	0.0	-0.1
Bone: marrow area	0.3	0.7	1.5	0.4	-1.2	1.2	0.5	0.2
Bone: maximum diameter	1.7	3.1	7.0	0.7	-2.7	2.7	0.9	0.6
Bone: maximum force	1.2	2.2	7.9	2.8	-0.7	0.7	1.4	0.3
Bone: maximum moment	1.2	2.1	6.9	2.6	-0.8	0.8	1.5	0.5
Mean time between licks in bursts	0.7	1.6	3.2	-0.2	-1.3	1.3	1.3	1.8
Mean num. licks in bursts	1.7	2.6	4.3	-1.1	1.3	-1.3	-2.1	-2.1
Cd content in liver	2.3	2.5	5.6	1.1	2.4	-2.4	0.1	-0.2
Co content in liver	1.2	1.4	2.6	1.3	1.6	-1.6	0.1	-0.5
Cu content in liver	0.3	0.3	0.6	-0.4	0.8	-0.8	-0.5	-0.3
Fe content in liver	2.4	3.0	3.5	1.3	-1.9	1.9	1.8	1.7
K content in liver	0.8	0.8	2.9	-1.7	0.0	-0.0	-0.9	-0.4
Mg content in liver	2.3	2.4	6.2	-2.5	0.5	-0.5	-1.9	-1.3
Mn content in liver	0.3	0.4	0.7	-0.7	0.1	-0.1	-0.8	-0.8
Na content in liver	1.4	1.5	3.2	-1.8	-0.2	0.2	-1.6	-1.2
Rb content in liver	0.4	0.5	1.6	-1.3	-0.5	0.5	-0.5	-0.1
Se content in liver	0.3	0.4	0.8	0.7	-0.1	0.1	0.8	0.9
Sr content in liver	1.5	1.3	2.5	-0.8	1.6	-1.6	-0.7	-0.5
Zn content in liver	3.0	3.3	3.8	-1.7	1.9	-1.9	-2.0	-1.7
Bone: minimum diameter	1.0	1.7	2.6	1.6	-1.6	1.6	0.9	0.2
Time in familiar zone, hab. session 1	1.0	1.0	2.6	-0.5	0.3	-0.3	-1.4	-1.6
Time in novel zone, hab. session 1	1.6	1.6	3.6	0.3	-1.0	1.0	1.5	1.9
Total zone transitions, hab. session 1	0.3	0.4	1.2	0.4	0.4	-0.4	-0.6	-1.1
Total locomotion distance, hab. session 1	1.0	1.4	2.6	1.4	-0.6	0.6	1.6	1.3
Locomotion velocity, hab. session 1	0.8	1.1	2.1	1.4	-0.4	0.4	1.4	1.1
Time in familiar zone, hab. session 2	1.3	1.4	2.5	-0.1	-1.6	1.6	0.8	1.1
Time in novel zone, hab. session 2	1.0	1.0	1.8	0.2	1.3	-1.3	-0.7	-0.9
Total zone transitions, hab. session 2	0.5	0.6	1.0	-0.6	0.5	-0.5	-1.0	-1.0
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.6	-0.2	0.2	0.3	-0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.3	-0.1	0.1	0.0	-0.3
Novel to familiar place preference ratio	1.5	1.6	2.9	1.2	-0.7	0.7	1.7	1.7
Novelty place preference	1.1	1.2	2.2	0.9	-0.7	0.7	1.5	1.5
Time in novel zone, NPP test	1.8	2.0	3.0	1.1	-1.2	1.2	1.7	1.7
Total zone transitions, NPP test	0.1	0.2	0.4	0.3	0.4	-0.4	-0.3	-0.6
Total locomotion distance, NPP test	0.6	0.8	2.6	1.6	0.2	-0.2	1.0	0.5
Locomotion velocity, NPP test	0.6	0.8	2.3	1.5	0.7	-0.7	0.8	0.3
Intraocular pressure	1.4	2.0	3.1	0.8	-1.8	1.8	1.3	1.3
Delta distance traveled before/after self-admin	0.4	0.4	1.1	-1.0	-0.4	0.4	-0.5	-0.4
Delta ambulatory time before/after self-admin	0.3	0.4	0.7	-0.9	-0.8	0.8	-0.1	-0.1
Parametrial fat weight	4.6	10.7	22.4	2.6	-4.7	4.7	1.4	0.1
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.9	-0.7	0.7	0.3	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	0.0	-0.0	-0.2	-0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.1	-0.0	0.0	-0.6	-0.9
Pavlov. Cond. index score	0.1	0.1	0.5	0.2	0.1	-0.1	-0.4	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.5	0.3	0.2	-0.2	-0.4	-0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.3	0.2	-0.2	-0.5	-0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.4	0.1	-0.1	0.6	0.7
Pavlov. Cond. intertrial magazine entries	1.2	1.5	6.3	2.5	0.2	-0.2	1.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.3	-0.0	0.0	-0.4	-0.7
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.1	0.3	-0.3	-0.6	-0.8
Pavlov. Cond. lever latency	1.1	1.6	2.8	-0.1	1.7	-1.7	-1.0	-1.1
Pavlov. Cond. magazine entry latency	0.7	0.8	1.3	-1.0	-1.2	1.2	-0.1	0.5
Pavlov. Cond. change in total contacts	0.6	0.9	1.8	-0.3	-1.3	1.3	0.6	0.8
Pavlov. Cond. index score	0.9	1.2	2.4	-0.3	-1.5	1.5	0.6	0.8
Pavlov. Cond. latency score	0.8	1.1	2.1	-0.3	-1.5	1.5	0.6	0.8
Pavlov. Cond. lever contacts	0.6	0.9	1.6	0.3	-1.2	1.2	0.8	0.7
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	0.7	1.0	-1.0	0.0	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.1	1.1	-0.2	0.2	0.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.8	-0.4	-1.3	1.3	0.4	0.6
Pavlov. Cond. response bias	1.2	1.6	2.8	0.0	-1.7	1.7	1.0	1.1
Time in closed arm before self-admin	0.3	0.4	0.9	-0.4	0.3	-0.3	-0.9	-1.0
Time in closed arm after self-admin	1.7	1.8	2.4	-0.8	1.4	-1.4	-1.6	-1.3
Time in open arm before self-admin	0.4	0.5	0.9	0.3	0.6	-0.6	0.8	0.9
Time in open arm after self-admin	1.7	1.9	3.1	-0.0	-1.5	1.5	1.5	1.8
Bone: periosteal estimation	1.1	2.3	4.3	2.1	-1.7	1.7	1.2	0.3
Bone: periosteal perimeter	1.1	1.9	4.3	0.7	-2.1	2.1	0.0	-0.5
Bone: post-yield work	2.2	3.2	5.8	2.4	-1.0	1.0	2.3	1.7
Progressive ratio test 1 active lever presses	1.1	1.3	3.1	-1.8	0.8	-0.8	-1.3	-0.8
Progressive ratio test 1 breakpoint	1.0	1.3	2.8	-1.7	0.8	-0.8	-1.3	-0.8
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.4	-0.7	-0.7	0.7	0.1	0.3
Progressive ratio test 2 active lever presses	0.5	0.6	1.2	-1.1	0.1	-0.1	-1.0	-0.9
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	-1.1	0.0	-0.0	-1.0	-0.9
Progressive ratio test 2 inactive lever presses	0.3	0.5	0.8	0.4	-0.7	0.7	0.9	0.9
Incentive Sensitization - Responses	0.3	0.4	0.5	-0.7	-0.5	0.5	-0.6	-0.7
Incentive Sensitization - Breakpoint	0.3	0.4	0.5	-0.7	-0.6	0.6	-0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.7	-1.3	-1.0	1.0	-0.2	0.2
Progressive ratio	0.3	0.5	1.3	-0.5	0.4	-0.4	0.7	1.1
Food seeking constrained by brief footshock	0.2	0.2	0.7	-0.8	0.1	-0.1	0.1	0.5
Seeking ratio, punishment vs. effort	0.7	0.9	2.3	-0.5	0.4	-0.4	-1.4	-1.5
Retroperitoneal fat weight	6.2	26.3	48.5	5.2	-7.0	7.0	2.6	0.2
Reaction time number correct	0.6	1.2	3.4	-1.9	-0.7	0.7	-1.0	-0.5
Reaction time mean minus median	0.5	1.2	2.4	-1.5	-0.2	0.2	-1.5	-1.3
Reaction time mean minus median AUC	1.8	4.5	8.4	-2.8	0.6	-0.6	-2.9	-2.4
Reaction time num false alarms	0.4	0.6	1.4	1.2	0.8	-0.8	0.1	-0.5
Reaction time num false alarms AUC	0.4	0.6	0.8	0.8	0.9	-0.9	-0.3	-0.8
Reaction time trials correct on left	0.6	1.2	3.4	-1.9	-0.7	0.7	-1.0	-0.5
Reaction time trials on left	0.7	1.3	3.8	-2.0	-0.8	0.8	-1.1	-0.6
Reaction time mean	2.5	3.9	9.2	-3.0	0.4	-0.4	-2.6	-1.8
Reaction time mean AUC	3.0	4.8	11.2	-3.3	0.6	-0.6	-2.9	-2.0
Median of all reaction times	3.2	4.5	10.5	-3.2	0.7	-0.7	-2.8	-1.9
Reaction time omissions	1.2	1.7	3.9	-2.0	-1.3	1.3	-1.1	-0.5
Reaction time false alarm rate	0.9	1.2	3.9	2.0	0.9	-0.9	0.6	-0.1
Reaction time premature initiation rate	0.4	0.5	0.7	0.7	0.7	-0.7	-0.5	-0.8
Reaction time premature initiations	0.3	0.5	1.2	-0.4	0.3	-0.3	-1.0	-1.1
Std. dev. reaction times	1.0	1.9	3.5	-1.9	-0.4	0.4	-1.8	-1.4
Reaction time trials completed	0.7	1.3	3.8	-2.0	-0.8	0.8	-1.1	-0.6
Reaction time trials AUC	0.6	1.2	3.2	-1.8	-0.8	0.8	-1.0	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.4	-0.5	0.5	0.1	0.2
Run reversals in cocaine runway, males	0.9	0.9	1.2	-0.4	1.1	-1.1	-1.1	-0.9
Latency to leave start box in cocaine runway	1.6	1.8	7.3	-2.7	-0.4	0.4	-1.2	-0.3
Latency to leave start box in cocaine runway, F	0.7	0.8	3.0	-1.7	-0.7	0.7	-0.6	0.0
Latency to leave start box in cocaine runway, M	1.1	1.0	2.7	-1.6	0.3	-0.3	-1.2	-0.8
Std. dev. time between licks in bursts	1.1	1.5	3.3	0.9	-0.3	0.3	1.8	1.8
Total sessions with >9 infusions	0.2	0.3	0.6	0.1	0.8	-0.8	-0.3	-0.3
Short access day 1 total inactive lever presses	1.1	1.5	2.7	0.9	-1.0	1.0	1.5	1.6
Short access day 10 total inactive lever presses	0.1	0.3	0.5	0.4	-0.7	0.7	-0.1	-0.2
Short access day 1 total infusions	0.1	0.2	0.3	-0.3	0.4	-0.4	-0.6	-0.4
Short access day 10 total infusions	1.2	1.5	2.4	-1.1	1.6	-1.6	-1.1	-0.7
Short access total infusions	0.5	0.6	1.3	-0.3	1.1	-1.1	-0.5	-0.3
Short access day 1 locomotion	0.6	0.8	2.0	-1.4	0.1	-0.1	-1.1	-0.9
Short access day 10 total locomotion	1.0	1.8	2.7	-1.2	1.1	-1.1	-1.6	-1.5
Short access total locomotion	2.1	2.5	3.1	-1.1	1.8	-1.8	-1.7	-1.6
One hour access (0.3 mA shock)	0.7	0.8	1.2	-1.1	-1.0	1.0	0.2	0.7
Compulsive drug intake	0.7	0.8	1.6	0.3	-1.3	1.3	0.6	0.8
One hour access (shock baseline)	0.2	0.3	1.1	-1.1	0.4	-0.4	-0.4	-0.1
Social response proportion	0.6	0.7	1.9	0.4	0.6	-0.6	-0.9	-1.4
Social responses	0.5	0.6	1.3	1.1	-0.9	0.9	0.3	-0.2
Social time	1.5	2.1	4.0	-1.7	0.5	-0.5	-2.0	-1.7
Soleus weight	2.1	6.3	13.8	-2.2	-0.1	0.1	-3.5	-3.7
Bone: stiffness	1.3	2.1	6.2	2.5	-0.7	0.7	1.7	0.9
Tibialis anterior weight	0.5	1.9	2.5	-1.6	-1.5	1.5	-1.2	-1.0
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.1	1.4	-0.2	0.2	1.3	0.8
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.7	-0.3	0.3	0.4	0.3
Time to tail flick, test, before self-admin	2.8	2.9	3.6	-1.0	1.9	-1.9	-1.7	-1.8
Time to tail flick, test, after self-admin	1.0	1.0	2.0	0.2	-0.9	0.9	1.1	1.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	-0.7	-1.0	1.0	-0.3	-0.1
Delta time to tail flick, test, before/after SA	2.2	2.2	3.7	1.1	-1.3	1.3	1.6	1.9
Tibia length	0.1	0.3	1.2	1.1	0.0	-0.0	0.4	-0.2
Ambulatory time before self-admin	2.3	3.4	5.6	-0.7	2.4	-2.4	-1.7	-1.6
Ambulatory time after self-admin	1.8	2.1	2.4	-1.5	1.4	-1.4	-1.5	-1.4
Bone: tissue strength	0.1	0.1	0.4	-0.2	-0.1	0.1	0.4	0.6
Total heroin consumption	1.0	1.2	2.9	-0.2	-1.7	1.7	0.1	-0.2
Bone: trabecular number	1.9	3.2	3.8	1.7	-1.9	1.9	1.9	1.4
Bone: trabecular spacing	0.3	0.4	1.5	-1.2	0.5	-0.5	-0.3	0.3
Bone: trabecular thickness	1.6	2.0	3.8	1.4	-1.9	1.9	0.7	0.0
Bone: trabecular tissue density	1.6	2.4	4.1	-2.0	1.3	-1.3	-1.8	-1.2
Water consumed over 24 hours	0.2	0.3	0.4	0.0	0.6	-0.6	-0.4	-0.5
Number of responses in last shaping day	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.5	-0.5