Slc16a8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Slc16a8	0.08	0.04	1.1e-08	0.07	0.04	0.05	0.07	1.0e-08	4.1e-05	1.2e-06	5.2e-08
2	Brain	gene expression	Slc16a8	0.03	0.02	7.7e-03	0.02	0.02	0.01	0.03	2.6e-03	7.5e-03	3.6e-02	1.3e-03
3	Brain	intron excision ratio	chr7_110819952_110820167	0.04	0.03	6.8e-03	0	0.01	-0	-0	3.0e-01	4.9e-02	4.2e-01	4.6e-01
4	NAcc	gene expression	Slc16a8	0.08	0.04	2.5e-11	0.1	0.08	0.08	0.1	1.3e-11	6.0e-10	2.8e-09	2.0e-11
5	PL	gene expression	Slc16a8	0.06	0.03	2.1e-07	0.07	0.06	0.06	0.06	7.8e-08	3.4e-07	1.6e-07	2.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.2	-0.2	-0.3	0.1	0.0
Area under the delay curve	3.7	3.9	6.0	2.2	-1.6	-2.5	1.8	1.7
BMI with tail	0.1	0.2	0.8	-0.3	-0.0	-0.9	0.1	0.2
BMI without tail	0.6	1.2	1.7	0.7	-1.2	-0.9	1.2	1.3
Body weight	1.3	5.6	10.9	-3.3	2.3	1.6	-2.2	-2.1
Weight adjusted by age	1.9	2.2	2.7	-0.7	1.6	1.6	-1.6	-1.6
Bone surface	0.0	0.0	0.0	0.1	0.0	-0.2	-0.1	0.0
Bone volume	0.0	0.1	0.1	0.2	-0.4	-0.1	0.2	0.3
Breakpoint value in progressive ratio session	1.3	1.4	1.7	0.9	-1.3	-1.2	1.1	1.3
Number of licking bursts	0.9	1.0	1.5	1.2	-1.1	0.1	1.0	1.2
Context. condit. distance diff. score	3.5	4.2	5.8	-2.4	1.8	2.0	-1.7	-2.3
Locomotion velocity, session 1	0.9	1.0	1.9	-0.7	1.4	0.4	-1.3	-0.9
Locomotion distance, session 1	2.3	3.0	6.4	2.5	-1.2	-1.5	1.5	1.7
Locomotion velocity, session 2	0.2	0.3	0.7	0.0	0.7	-0.8	-0.4	-0.0
Locomotion distance, session 2	2.9	4.1	6.0	2.4	-1.4	-2.3	1.8	1.9
Locomotion velocity, session 3	1.4	1.6	3.5	-1.1	1.0	1.9	-0.9	-1.3
Locomotion distance, session 3	1.2	1.3	1.9	1.4	-1.3	0.7	1.1	1.1
Stereotopy head waving bouts, day 3	1.2	1.4	2.1	-1.5	1.3	0.3	-1.3	-1.1
Stereotopy head waving duration, day 3	5.1	6.1	8.8	-2.5	3.0	1.3	-2.7	-2.5
Locomotion velocity, session 7	1.1	1.2	1.7	-0.5	1.2	1.3	-1.2	-1.1
Locomotion distance, session 7	0.6	0.7	1.2	-0.2	0.9	0.9	-0.9	-1.1
Stereotopy head waving bouts, day 7	5.3	6.0	8.8	-2.3	3.0	1.8	-2.7	-2.3
Stereotopy head waving duration, day 7	2.9	3.5	5.0	-1.7	2.2	1.3	-2.1	-1.8
Locomotion velocity, session 8	2.7	3.2	4.9	-1.7	2.2	0.9	-1.9	-1.9
Locomotion distance, session 8	0.4	0.6	1.3	-0.5	1.0	0.4	-0.7	-1.1
Degree of sensitization distance	4.8	4.8	6.8	-2.2	2.6	0.6	-2.4	-2.6
Degree of sensitization stereotypy	3.2	3.5	5.6	-1.4	2.4	1.4	-2.2	-1.8
Conditioned locomotion	1.2	1.4	1.9	-0.9	1.3	1.2	-1.4	-1.1
Cocaine response after cond. corrected	0.5	0.6	0.8	-0.8	0.9	-0.4	-0.8	-0.8
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.5	0.4	-0.7	-0.4	-0.3
Cocaine response before conditioning	1.1	1.3	2.0	1.1	-1.3	-0.4	1.2	1.4
Saline control response	0.3	0.4	0.8	-0.8	0.2	0.9	-0.4	-0.7
Bone: connectivity density	0.2	0.3	0.5	-0.4	0.4	0.6	-0.5	-0.7
Bone: cortical apparent density	0.5	0.7	1.8	0.7	-0.9	1.3	0.5	0.3
Bone: cortical area	0.1	0.2	0.4	-0.7	0.5	-0.1	-0.6	0.0
Bone: cortical porosity	1.0	1.1	1.9	-1.4	1.2	-0.6	-0.9	-0.9
Bone: cortical porosity	1.4	1.5	2.9	-1.7	1.4	-0.7	-1.1	-1.0
Bone: cortical thickness	1.5	2.4	3.6	1.0	-1.9	-1.2	1.6	1.9
Bone: cortical thickness	2.6	3.0	4.7	1.3	-2.0	-1.5	1.6	2.2
Bone: cortical tissue density	0.5	0.6	2.0	0.6	-0.7	1.4	0.4	0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.1	-0.6	0.7	0.4	0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	-0.4	-0.2	1.1	-0.0	0.1
Condit. Reinf. active responses	0.7	0.8	1.7	0.4	-1.3	0.5	1.0	0.9
Condit. Reinf. inactive responses	1.0	1.2	2.5	0.9	-1.6	0.0	1.4	0.8
Incentive salience index mean	0.3	0.4	1.0	0.2	-0.6	1.0	0.4	0.7
Condit. Reinf. lever presses	0.4	0.6	1.0	0.3	-0.8	1.0	0.6	0.9
Condit. Reinf. active minus inactive responses	0.3	0.4	1.5	0.4	-0.2	-1.2	0.4	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.6	0.3	-0.7	-0.3	-0.3
Condit. Reinf. active responses	0.3	0.4	1.7	0.3	0.0	-1.3	0.2	0.0
Condit. Reinf. inactive responses	0.3	0.3	0.9	1.0	-0.3	-0.4	0.4	0.5
Condit. Reinf. lever presses	0.5	0.7	1.0	1.0	-0.9	-0.8	0.9	0.7
Condit. Reinf. lever reinforcers received	0.2	0.3	1.3	0.1	0.2	-1.2	-0.0	-0.1
Conditioned reinforcement - actives	1.7	1.7	2.5	1.0	-1.2	-1.6	1.3	1.3
Conditioned reinforcement - inactives	1.9	2.2	3.3	1.1	-1.8	-1.1	1.5	1.7
Conditioned locomotion	0.8	1.0	3.5	-0.1	-0.5	-1.9	0.7	0.7
Patch foraging indifference point 0 sec	0.2	0.4	1.2	-0.1	0.3	1.1	-0.3	-0.6
Patch foraging indifference point AUC	1.0	1.1	1.4	1.1	-1.2	-0.6	1.1	1.2
Delay disc. indifference point, 0s delay	0.6	0.7	2.3	-0.2	-0.5	-1.5	0.7	0.7
Delay disc. indifference point, 16s delay	3.5	3.5	5.2	2.2	-1.5	-2.3	1.7	1.6
Delay disc. indifference point, 2s delay	8.3	9.2	17.9	2.7	-2.4	-4.2	2.8	2.7
Delay disc. indifference point, 24s delay	0.6	0.6	1.6	0.5	0.7	1.3	-0.6	-0.6
Delay disc. indifference point, 4s delay	1.8	1.9	5.2	1.4	-0.7	-2.3	1.0	0.9
Delay disc. indifference point, 8s delay	2.5	2.5	3.4	1.8	-1.6	-1.3	1.6	1.6
Indifference point function ln k	1.5	2.2	3.1	-1.8	1.4	1.1	-1.3	-1.6
Indifference point function log k	1.5	2.2	3.1	-1.8	1.4	1.1	-1.3	-1.6
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.3	-0.3	0.6	0.2	-0.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.2	-0.2	0.0	0.1	0.0
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.1	-0.3	0.1	0.3	0.3
Patch foraging total patch changes 24 sec	0.9	1.1	1.7	0.9	-1.3	0.2	1.0	1.3
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	0.4	-0.4	-0.1	0.4	0.5
Patch foraging time to switch 0 sec	0.5	0.7	3.0	-0.1	0.6	-1.7	-0.2	-0.3
Patch foraging water rate 0 sec	1.1	1.7	6.2	-0.8	0.5	2.5	-1.0	-0.7
Patch foraging water rate 12 sec	0.3	0.5	2.2	-0.2	-0.3	1.5	-0.1	0.5
Patch foraging water rate 18 sec	1.3	1.8	6.4	-0.8	0.7	2.5	-1.1	-0.5
Patch foraging water rate 24 sec	2.7	3.7	5.8	-2.1	1.6	2.4	-1.8	-1.6
Patch foraging water rate 6 sec	0.6	0.9	3.9	-0.5	-0.6	2.0	0.3	0.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.9	0.9	0.3	-0.5	0.1	0.1
Distance traveled before self-admin	2.2	2.3	6.5	1.1	-1.1	-2.6	1.2	1.1
Distance traveled after self-admin	0.5	0.5	0.7	-0.8	0.9	0.2	-0.8	-0.7
Extensor digitorum longus weight	1.0	4.0	6.1	2.1	-1.6	-2.5	1.9	1.9
Bone: elastic displacement	1.1	1.3	2.1	-0.7	1.5	0.8	-1.3	-1.2
Bone: elastic work	2.6	3.4	5.7	-1.7	2.4	0.2	-2.4	-1.7
Bone: endosteal estimation	2.2	4.7	6.9	-2.3	2.6	0.9	-2.5	-2.1
Bone: endosteal perimeter	2.3	4.8	7.6	-2.2	2.7	1.1	-2.6	-2.0
Epididymis fat weight	0.8	1.9	4.4	-2.1	1.1	1.1	-1.1	-1.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.1	-0.6	-0.8	0.6	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.3	-0.3	-0.5	0.3	0.3
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.5	-0.6	0.2	0.4	0.7
Delay discount exponential model param	3.8	4.0	5.6	-2.2	1.6	2.4	-1.8	-1.8
Extinction: sum of active levers before priming	3.0	3.0	4.0	1.9	-1.5	-2.0	1.5	1.7
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1
Bone: final force	0.5	0.7	1.4	-0.8	1.1	-0.4	-1.2	-0.5
Bone: final moment	0.7	1.1	2.0	-1.1	1.3	-0.2	-1.4	-0.8
Food consumed during 24 hour testing period	0.2	0.2	0.7	-0.8	-0.0	-0.5	-0.0	0.2
Glucose	0.1	0.2	0.6	-0.8	-0.1	0.4	-0.1	0.1
Heart weight	2.7	3.8	6.7	-2.6	1.3	2.3	-1.8	-1.3
Delay discount hyperbolic model param	4.5	4.8	7.6	-2.3	1.7	2.8	-2.0	-1.9
Intermittent access intake day 1-15 change	0.7	0.7	1.3	0.6	-1.1	-0.0	0.8	1.0
Intermittent access intake escalation	1.3	1.3	2.3	0.8	-1.5	-0.4	1.2	1.4
Intermittent access intake escalation 2	0.6	0.6	1.4	0.4	-1.2	-0.0	0.7	1.0
Intermitt. access day 1 inactive lever presses	0.8	0.9	1.3	-0.8	1.0	0.4	-1.2	-1.0
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.4	0.2	0.2	-0.2	-0.3
Intermitt. access escalation Index	0.8	0.7	0.9	0.9	-0.9	-0.6	1.0	0.9
Intermittent access day 1 total infusions	0.3	0.4	1.9	-0.2	0.0	-1.4	0.1	0.2
Intermittent access day 15 total infusions	0.6	0.6	1.2	0.3	-0.8	-1.1	0.6	0.9
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.3	-0.6	-0.8	0.4	0.7
Intermittent access total infusions	0.7	0.8	3.1	0.3	-0.5	-1.8	0.5	0.7
Intermittent access day 1 locomotion	0.2	0.2	0.9	-0.4	-0.1	-0.9	0.1	0.2
Intermittent access day 15 total locomotion	0.2	0.2	0.3	-0.2	-0.6	-0.3	0.3	0.6
Intermittent access total locomotion	0.2	0.2	0.8	-0.9	-0.2	-0.5	-0.1	0.2
Intermittent access standard deviation	0.5	0.6	1.3	-0.7	-0.6	-1.2	0.5	0.6
Left kidney weight	6.5	18.3	26.6	-5.2	4.5	2.8	-4.5	-4.1
Right kidney weight	7.4	20.9	35.2	-5.9	4.4	3.3	-4.4	-4.4
Cocaine induced anxiety	0.4	0.5	0.8	-0.7	0.9	-0.2	-0.6	-0.8
Post-drug Anxiety	5.1	5.7	7.4	-1.9	2.7	1.9	-2.5	-2.7
Baseline Anxiety	1.1	1.2	3.7	-0.2	0.6	1.9	-1.0	-0.9
Tail length	0.3	0.9	2.6	-1.3	0.2	1.6	-0.2	-0.3
Length with tail	2.7	9.7	13.8	-3.7	2.8	3.2	-2.9	-2.9
Length without tail	4.1	8.9	12.1	-3.5	3.0	2.3	-3.0	-3.0
Times rat made contact with spout	1.2	1.4	2.1	0.3	-1.4	1.5	1.0	1.3
Lifetime Intake	0.7	0.8	3.3	0.1	-0.4	-1.8	0.4	0.6
Liver weight, left	1.3	2.1	3.1	-1.6	1.8	0.9	-1.5	-1.3
Liver weight, right	1.9	3.1	3.6	-1.9	1.8	1.8	-1.6	-1.7
Locomotor activity	0.7	1.2	3.3	-1.8	0.7	0.8	-0.7	-1.0
Locomotor testing distance	0.7	1.1	2.3	0.1	-1.5	-0.1	1.3	1.2
Locomotor testing rearing	0.3	0.4	2.1	-1.4	-0.1	0.2	-0.0	-0.1
Locomotion in novel chamber	1.4	1.8	3.2	1.8	-1.5	0.4	1.2	1.4
Locomotion in novel chamber post-restriction	4.0	4.8	6.4	2.2	-2.2	-1.7	2.3	2.5
Fecal boli incidents, locomotor time 1	0.3	0.3	0.7	-0.2	0.6	0.6	-0.8	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.4	1.7	-0.5	0.3	1.3	-0.1	-0.5
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.3	-1.1	1.1	0.2	-1.0	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.4	0.3	0.6	-0.3	-0.2
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	0.5	0.4	-0.6	-0.5
Rest time, locomotor task time 1	0.6	0.7	1.0	-0.5	1.0	0.8	-0.9	-1.0
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.5	0.3	0.6	-0.5	-0.5
Vertical activity count, locomotor time 1	0.6	0.7	1.9	-1.1	0.0	1.4	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	2.6	2.8	4.6	-0.8	1.8	2.1	-1.9	-1.4
Bouts of movement, locomotor time 2	3.4	3.6	5.0	1.3	-1.9	-2.1	1.9	2.2
Total resting periods, locomotor time 2	4.1	4.4	6.3	1.4	-2.0	-2.5	2.0	2.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	-0.2	-0.4	0.2	0.1
Distance moved, locomotor task time 2	1.4	1.6	2.3	-1.0	1.1	1.5	-1.4	-1.2
Vertical activity count, locomotor time 2	1.4	1.5	3.5	-1.3	0.8	1.9	-1.2	-0.7
Light reinforcement 1	0.0	0.1	0.1	-0.4	0.2	0.0	-0.2	-0.3
Light reinforcement 2	0.1	0.1	0.3	-0.6	0.1	-0.3	0.0	-0.1
Bone: marrow area	2.4	5.1	7.4	-2.3	2.7	1.0	-2.6	-2.2
Bone: maximum diameter	2.5	4.6	7.2	-2.5	2.7	0.9	-2.4	-1.6
Bone: maximum force	0.7	1.2	2.0	-1.3	1.3	-0.4	-1.4	-0.7
Bone: maximum moment	0.9	1.6	2.6	-1.5	1.5	-0.3	-1.6	-1.0
Mean time between licks in bursts	0.4	0.5	1.3	1.2	0.3	-1.1	-0.1	0.0
Mean num. licks in bursts	0.3	0.4	1.0	-0.9	0.0	1.0	-0.2	-0.3
Cd content in liver	0.3	0.3	0.5	0.1	-0.6	-0.7	0.5	0.7
Co content in liver	0.3	0.4	1.1	0.3	-0.6	-0.5	0.4	1.0
Cu content in liver	3.2	3.8	6.4	2.5	-1.9	-1.2	1.8	2.0
Fe content in liver	3.8	4.5	6.4	-2.5	2.2	1.4	-2.2	-2.0
K content in liver	0.2	0.2	0.7	0.5	0.1	-0.8	-0.0	-0.2
Mg content in liver	0.1	0.1	0.3	0.3	0.2	-0.5	-0.2	-0.4
Mn content in liver	1.2	1.3	1.9	1.1	-1.3	-1.0	1.4	1.0
Na content in liver	0.1	0.1	0.1	0.2	-0.4	0.0	0.2	0.2
Rb content in liver	0.0	0.1	0.2	-0.0	0.2	0.1	-0.1	-0.4
Se content in liver	1.5	1.8	3.2	1.3	-1.4	-0.4	1.4	1.8
Sr content in liver	5.5	5.0	6.2	2.3	-2.5	-1.6	2.4	2.2
Zn content in liver	0.5	0.6	1.2	1.1	-0.6	-0.4	0.6	0.9
Bone: minimum diameter	0.3	0.5	1.1	-1.0	0.8	-0.2	-0.7	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.3	0.8	0.5	-0.8	-0.1
Time in novel zone, hab. session 1	0.4	0.4	1.0	-1.0	0.4	0.2	-0.2	-0.8
Total zone transitions, hab. session 1	1.9	2.7	4.2	2.1	-1.7	-0.6	1.8	1.6
Total locomotion distance, hab. session 1	0.7	0.9	1.4	1.0	-1.1	0.2	1.2	1.1
Locomotion velocity, hab. session 1	0.9	1.2	1.9	1.0	-1.2	-0.1	1.4	1.3
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.7	-0.3	0.8	0.2	0.6
Time in novel zone, hab. session 2	0.5	0.5	1.3	-0.7	-0.5	-1.1	0.5	0.0
Total zone transitions, hab. session 2	0.5	0.6	1.7	1.3	-0.5	-0.1	0.7	0.8
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.7	-0.1	-0.7	0.4	0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.8	0.9	-0.1	-0.5	0.3	0.6
Novel to familiar place preference ratio	1.1	1.1	2.3	-1.5	0.9	1.0	-0.9	-1.0
Novelty place preference	1.3	1.3	2.7	-1.6	0.9	1.2	-0.8	-1.0
Time in novel zone, NPP test	1.4	1.5	3.2	-1.8	0.9	1.3	-0.8	-1.0
Total zone transitions, NPP test	1.6	2.3	4.8	2.2	-1.4	-0.4	1.5	1.6
Total locomotion distance, NPP test	0.1	0.2	0.9	0.9	-0.0	-0.1	0.2	0.2
Locomotion velocity, NPP test	0.4	0.6	2.1	1.4	-0.4	-0.3	0.5	0.6
Intraocular pressure	0.2	0.3	0.7	-0.2	0.8	0.2	-0.7	-0.7
Delta distance traveled before/after self-admin	5.0	5.4	9.4	-2.2	2.1	3.1	-2.1	-2.0
Delta ambulatory time before/after self-admin	5.4	5.9	8.9	-2.2	2.3	3.0	-2.4	-2.2
Parametrial fat weight	0.3	0.6	2.8	-0.2	0.0	1.7	-0.2	-0.3
Pavlov. Cond. lever latency	0.2	0.2	0.6	-0.5	0.3	-0.1	-0.3	-0.8
Pavlov. Cond. magazine entry latency	1.2	1.5	2.4	1.2	-0.9	-1.5	1.0	1.4
Pavlov. Cond. change in total contacts	1.7	1.8	2.6	1.3	-1.2	-1.4	1.1	1.6
Pavlov. Cond. index score	0.2	0.2	0.6	0.4	-0.2	-0.5	0.2	0.8
Pavlov. Cond. latency score	0.1	0.1	0.4	0.3	-0.1	-0.3	0.2	0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.6	0.6	-0.3	-0.2	0.3	0.7
Pavlov. Cond. magazine entry number	0.8	0.9	1.5	-1.0	0.8	0.9	-0.8	-1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	0.0	-0.6	0.9	0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.7	-0.5	-0.5	0.5	1.0
Pavlov. Cond. response bias	0.6	0.7	1.4	0.9	-0.7	-0.8	0.6	1.2
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.1	-0.6	-0.4	0.6	0.7
Pavlov. Cond. magazine entry latency	0.7	0.8	1.1	0.8	-1.0	-1.0	0.9	0.8
Pavlov. Cond. change in total contacts	2.3	3.2	4.8	-1.3	2.2	0.7	-2.2	-2.1
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1	-0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.1	0.4	0.5	-0.4	-0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.4	-0.1	0.4	-0.0	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.2	-0.0	-0.2	-0.1	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.3
Time in closed arm before self-admin	0.8	0.9	1.5	0.9	-0.9	-1.2	0.9	0.9
Time in closed arm after self-admin	0.2	0.2	0.9	-0.9	0.2	0.3	-0.2	-0.3
Time in open arm before self-admin	0.9	0.9	2.4	-0.3	0.8	1.6	-0.9	-0.9
Time in open arm after self-admin	0.2	0.3	0.4	0.6	-0.6	0.3	0.5	0.5
Bone: periosteal estimation	1.3	2.8	4.1	-1.9	2.0	0.5	-2.0	-1.4
Bone: periosteal perimeter	2.9	4.8	6.8	-2.4	2.6	1.3	-2.5	-1.7
Bone: post-yield work	0.1	0.1	0.1	-0.0	0.2	-0.4	-0.4	0.2
Progressive ratio test 1 active lever presses	0.6	0.6	2.0	0.5	-0.5	-1.4	0.5	0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	0.4	-0.3	-0.8	0.3	0.4
Progressive ratio test 1 inactive lever presses	1.4	1.6	5.1	1.0	-0.7	-2.3	0.8	0.8
Progressive ratio test 2 active lever presses	1.2	1.3	1.8	0.9	-1.4	-0.9	1.1	1.3
Progressive ratio test 2 breakpoint	0.6	0.7	0.8	0.7	-0.9	-0.8	0.7	0.9
Progressive ratio test 2 inactive lever presses	2.0	2.4	2.6	1.6	-1.6	-1.4	1.5	1.6
Incentive Sensitization - Responses	0.5	0.5	1.0	0.8	-1.0	0.2	0.6	0.9
Incentive Sensitization - Breakpoint	0.5	0.6	1.0	0.8	-1.0	0.2	0.6	0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.9	0.4	-0.2	-0.9	0.1	0.2
Progressive ratio	0.1	0.2	0.5	-0.3	0.3	-0.7	-0.2	-0.4
Food seeking constrained by brief footshock	0.2	0.3	0.7	0.0	-0.5	-0.6	0.3	0.9
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	0.4	-0.4	0.0	0.2	0.8
Retroperitoneal fat weight	2.9	9.4	15.1	-3.9	3.0	2.7	-2.9	-2.7
Reaction time number correct	0.8	1.2	2.2	1.5	-1.1	0.3	1.0	1.3
Reaction time mean minus median	0.0	0.1	0.1	-0.2	0.3	-0.1	-0.2	-0.4
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.5	0.3	0.1	-0.3	-0.5
Reaction time num false alarms	0.1	0.1	0.3	-0.3	-0.6	0.1	0.3	0.4
Reaction time num false alarms AUC	0.1	0.2	0.5	-0.1	-0.7	0.0	0.4	0.4
Reaction time trials correct on left	0.8	1.2	2.2	1.5	-1.1	0.3	1.0	1.3
Reaction time trials on left	1.0	1.4	2.5	1.6	-1.2	0.2	1.1	1.4
Reaction time mean	0.5	0.7	1.3	-0.7	0.9	0.3	-0.9	-1.2
Reaction time mean AUC	0.3	0.4	0.8	-0.5	0.6	0.2	-0.6	-0.9
Median of all reaction times	0.5	0.6	1.2	-0.6	0.9	0.2	-0.9	-1.1
Reaction time omissions	2.7	3.7	7.0	1.9	-1.4	-2.6	1.8	1.7
Reaction time false alarm rate	0.1	0.1	0.4	-0.6	-0.3	-0.2	0.1	-0.2
Reaction time premature initiation rate	0.2	0.2	0.7	-0.8	0.5	-0.2	-0.3	-0.3
Reaction time premature initiations	0.0	0.0	0.0	-0.2	0.0	0.1	0.2	0.2
Std. dev. reaction times	0.3	0.5	0.8	-0.8	0.7	0.3	-0.6	-0.9
Reaction time trials completed	1.0	1.4	2.5	1.6	-1.2	0.2	1.1	1.4
Reaction time trials AUC	0.7	1.0	1.8	1.3	-1.0	0.3	0.9	1.2
Run reversals in cocaine runway, females	0.6	0.6	2.4	0.1	0.4	1.5	-0.2	-0.5
Run reversals in cocaine runway, males	0.4	0.4	1.1	-0.5	0.5	0.6	-0.4	-1.0
Latency to leave start box in cocaine runway	0.8	0.9	1.5	-0.6	1.2	-0.5	-0.9	-1.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.8	0.3	0.9	-0.9	-0.5	-0.6
Latency to leave start box in cocaine runway, M	0.5	0.5	1.2	-1.1	0.6	-0.2	-0.4	-0.9
Std. dev. time between licks in bursts	0.4	0.4	0.9	-0.2	0.9	0.2	-1.0	-0.7
Total sessions with >9 infusions	0.1	0.1	0.4	-0.6	0.2	-0.4	-0.2	-0.1
Short access day 1 total inactive lever presses	0.9	1.0	1.4	-1.0	1.2	-0.6	-1.0	-1.1
Short access day 10 total inactive lever presses	2.9	3.2	5.8	-1.8	1.3	2.4	-1.7	-1.6
Short access day 1 total infusions	0.2	0.2	0.3	-0.6	0.5	-0.2	-0.5	-0.5
Short access day 10 total infusions	0.5	0.5	2.2	-0.6	0.2	-1.5	0.0	0.1
Short access total infusions	0.4	0.5	1.0	-0.8	0.6	-1.0	-0.4	-0.4
Short access day 1 locomotion	0.3	0.3	1.2	-0.2	-0.0	-1.1	0.4	0.2
Short access day 10 total locomotion	0.9	1.0	1.7	0.1	-1.3	-1.1	1.0	1.2
Short access total locomotion	0.3	0.3	0.9	-0.9	0.2	-0.7	-0.2	-0.1
One hour access (0.3 mA shock)	5.1	6.0	6.8	2.3	-2.5	-2.4	2.4	2.6
Compulsive drug intake	1.9	1.9	3.3	1.4	-1.8	-0.0	1.4	1.5
One hour access (shock baseline)	0.8	1.0	2.1	0.6	-0.8	-1.5	0.9	1.0
Social response proportion	1.0	1.0	3.3	0.4	1.0	-1.8	-0.6	-0.6
Social responses	0.5	0.6	1.6	1.1	-0.2	-1.3	0.5	0.2
Social time	2.2	2.9	3.9	2.0	-1.5	-1.9	1.4	1.6
Soleus weight	0.4	1.2	2.2	0.2	-1.5	0.4	1.1	1.5
Bone: stiffness	0.9	1.4	2.1	-1.4	1.3	0.2	-1.4	-1.0
Tibialis anterior weight	3.4	11.6	12.1	3.3	-3.4	-3.5	3.4	3.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.2	0.1
Time to tail flick, vehicle, after self-admin	0.4	0.4	1.4	-0.4	0.4	1.2	-0.4	-0.4
Time to tail flick, test, before self-admin	1.6	1.6	1.9	1.1	-1.4	-1.1	1.4	1.3
Time to tail flick, test, after self-admin	0.3	0.3	0.9	0.9	-0.4	0.7	0.2	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.1	0.3	0.2	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	0.6	-0.3	1.0	0.2	0.2
Tibia length	0.5	1.4	2.2	-1.4	1.3	0.6	-1.5	-1.0
Ambulatory time before self-admin	2.4	2.5	4.2	1.3	-1.5	-2.1	1.5	1.4
Ambulatory time after self-admin	0.2	0.2	0.3	-0.4	0.4	0.5	-0.6	-0.4
Bone: tissue strength	0.2	0.2	0.4	-0.6	0.5	-0.0	-0.5	-0.6
Total heroin consumption	1.4	1.6	2.1	0.9	-1.3	-1.5	1.3	1.4
Bone: trabecular number	0.1	0.2	0.4	-0.0	0.2	0.7	-0.4	-0.4
Bone: trabecular spacing	0.3	0.5	0.7	-0.8	0.8	0.4	-0.8	-0.5
Bone: trabecular thickness	0.1	0.1	0.3	0.3	-0.5	0.1	0.3	0.2
Bone: trabecular tissue density	0.1	0.1	0.3	0.1	0.0	0.6	0.1	-0.2
Water consumed over 24 hours	0.3	0.3	0.5	-0.2	-0.7	0.6	0.4	0.6
Number of responses in last shaping day	4.2	4.4	10.9	1.6	-1.5	-3.3	1.6	1.8