Slc16a8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	isoform ratio	XM_063264226.1	0.32	0.15	6.0e-03	0.15	0.04	0.16	0.06	2.7e-03	7.7e-02	2.1e-03	3.9e-02
2	Eye	isoform ratio	NM_031744.2	0.33	0.16	6.6e-03	0.13	0.07	0.13	0.06	4.5e-03	3.6e-02	5.7e-03	4.5e-02
3	Adipose	gene expression	Slc16a8	0.04	0.03	9.5e-06	0.04	0.03	0.03	0.04	1.3e-05	3.5e-04	1.1e-04	5.6e-05
4	NAcc	gene expression	Slc16a8	0.06	0.03	2.4e-12	0.08	0.08	0.08	0.08	4.6e-12	1.1e-12	2.9e-12	3.5e-12
5	Brain	intron excision ratio	chr7_112700379_112700594	0.05	0.03	1.6e-03	0.01	0.02	0.01	0.01	1.7e-02	4.2e-03	6.4e-02	1.8e-02
6	PL	gene expression	Slc16a8	0.04	0.02	7.2e-06	0.04	0.04	0.04	0.05	3.2e-05	9.8e-06	1.1e-05	8.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	-0.3	-0.2
Area under the delay curve	4.0	4.7	5.9	2.4	-2.4	-1.9	-1.7	-2.4	-2.0
BMI with tail	0.3	1.0	1.4	-1.2	1.2	0.9	0.9	0.7	1.0
BMI without tail	0.5	1.5	2.7	-1.0	1.0	0.8	1.0	1.6	1.6
Body weight	2.3	10.0	12.4	-3.5	3.5	3.2	2.8	2.8	3.1
Weight adjusted by age	0.7	1.1	2.5	-0.0	0.1	0.8	1.2	1.4	1.6
Bone surface	0.1	0.1	0.4	0.2	-0.2	-0.1	-0.2	-0.2	-0.6
Bone volume	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.4	-0.2	-0.4
Breakpoint value in progressive ratio session	0.3	0.4	0.7	0.6	-0.5	-0.5	-0.5	-0.8	-0.8
Number of licking bursts	0.7	1.1	1.8	1.3	-1.3	-1.3	-1.2	-0.1	-0.4
Context. condit. distance diff. score	4.6	5.5	7.1	-2.7	2.7	2.6	2.1	2.2	1.7
Locomotion velocity, session 1	0.7	0.7	1.4	-0.7	0.7	0.9	1.2	0.6	0.9
Locomotion distance, session 1	3.1	3.9	5.5	2.3	-2.3	-2.1	-1.7	-1.5	-1.6
Locomotion velocity, session 2	0.1	0.1	0.4	-0.2	0.2	0.1	0.4	-0.6	-0.4
Locomotion distance, session 2	3.3	4.5	5.8	2.1	-2.1	-2.2	-2.0	-2.4	-2.1
Locomotion velocity, session 3	1.2	1.3	3.8	-0.9	0.9	0.9	1.0	1.9	1.0
Locomotion distance, session 3	1.6	1.7	2.5	1.6	-1.6	-1.5	-1.4	0.5	-0.9
Stereotopy head waving bouts, day 3	1.3	1.6	2.2	-1.5	1.5	1.5	1.3	0.4	1.0
Stereotopy head waving duration, day 3	5.1	6.1	7.6	-2.6	2.6	2.7	2.8	1.4	2.4
Locomotion velocity, session 7	0.7	0.7	1.7	-0.4	0.4	0.2	1.0	1.3	1.2
Locomotion distance, session 7	0.5	0.6	1.4	-0.5	0.5	0.5	0.7	0.9	1.2
Stereotopy head waving bouts, day 7	3.1	3.5	5.7	-1.5	1.5	1.9	2.4	2.0	1.8
Stereotopy head waving duration, day 7	2.1	2.5	4.6	-1.3	1.3	1.7	2.1	1.5	1.4
Locomotion velocity, session 8	2.5	3.0	4.1	-1.9	1.9	1.9	2.0	1.1	1.3
Locomotion distance, session 8	0.4	0.6	0.9	-0.9	0.9	0.8	0.9	0.5	0.3
Degree of sensitization distance	5.5	5.6	6.8	-2.6	2.6	2.6	2.6	0.9	2.5
Degree of sensitization stereotypy	1.9	2.1	4.3	-1.0	1.0	1.5	2.1	1.6	1.3
Conditioned locomotion	1.5	1.8	2.8	-1.2	1.2	1.0	1.4	1.3	1.7
Cocaine response after cond. corrected	0.3	0.4	0.7	-0.8	0.8	0.6	0.8	-0.2	0.3
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.5	0.5	0.2	0.4	-0.6	-0.1
Cocaine response before conditioning	0.9	1.0	1.9	0.9	-0.9	-1.4	-1.2	-0.5	-1.1
Saline control response	0.4	0.5	0.8	-0.9	0.9	0.9	0.3	0.8	-0.0
Bone: connectivity density	0.2	0.3	0.4	-0.6	0.6	0.5	0.5	0.6	0.4
Bone: cortical apparent density	0.4	0.5	1.6	0.6	-0.6	-0.4	-0.7	1.3	0.1
Bone: cortical area	0.3	0.4	0.7	-0.9	0.9	0.8	0.6	0.1	0.2
Bone: cortical porosity	0.6	0.7	1.2	-1.1	1.1	0.9	0.6	-0.6	-0.2
Bone: cortical porosity	1.5	1.6	2.9	-1.7	1.7	1.4	1.3	-0.2	0.3
Bone: cortical thickness	0.8	1.2	2.3	0.7	-0.7	-0.9	-1.4	-1.2	-1.5
Bone: cortical thickness	1.5	1.8	2.5	1.0	-1.0	-1.4	-1.5	-1.6	-1.5
Bone: cortical tissue density	0.3	0.5	1.8	0.5	-0.5	-0.4	-0.6	1.3	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.5	0.5	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.1	-0.2	0.2	0.1	-0.0	1.1	0.2
Condit. Reinf. active responses	0.3	0.4	1.1	0.7	-0.7	-0.6	-1.0	0.2	-0.1
Condit. Reinf. inactive responses	0.5	0.6	1.4	0.9	-0.9	-0.7	-1.2	-0.2	-0.1
Incentive salience index mean	0.2	0.3	0.5	0.4	-0.4	-0.6	-0.6	0.7	0.3
Condit. Reinf. lever presses	0.3	0.4	0.7	0.5	-0.5	-0.9	-0.6	0.8	0.6
Condit. Reinf. active minus inactive responses	0.3	0.3	1.5	0.2	-0.2	-0.2	-0.3	-1.2	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.5	0.5	0.4	0.4	-0.6	-0.0
Condit. Reinf. active responses	0.2	0.3	1.4	0.0	-0.0	-0.1	-0.0	-1.2	-0.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.5	-0.5	-0.7
Condit. Reinf. lever presses	0.4	0.6	1.0	0.6	-0.6	-0.9	-0.7	-1.0	-0.6
Condit. Reinf. lever reinforcers received	0.2	0.2	1.2	-0.2	0.2	0.1	0.2	-1.1	-0.4
Conditioned reinforcement - actives	1.7	2.9	4.1	1.4	-1.4	-1.5	-1.9	-2.0	-2.0
Conditioned reinforcement - inactives	2.5	3.7	5.5	1.4	-1.4	-1.9	-2.3	-2.3	-1.9
Conditioned locomotion	1.2	1.5	5.6	0.2	-0.2	-0.5	-0.9	-2.4	-1.6
Patch foraging indifference point 0 sec	0.5	0.9	1.2	-1.0	1.1	0.7	0.4	1.0	1.1
Patch foraging indifference point AUC	0.8	1.1	1.7	1.3	-1.3	-1.3	-1.2	-0.4	-0.5
Delay disc. indifference point, 0s delay	0.4	0.4	1.7	-0.3	0.3	0.2	-0.2	-1.3	-0.6
Delay disc. indifference point, 16s delay	3.9	4.3	5.4	2.3	-2.3	-1.9	-1.7	-2.3	-1.8
Delay disc. indifference point, 2s delay	9.1	10.1	17.3	2.9	-2.9	-2.6	-2.7	-4.2	-3.5
Delay disc. indifference point, 24s delay	0.5	0.5	1.3	0.7	-0.7	-0.3	0.1	1.2	0.8
Delay disc. indifference point, 4s delay	2.2	2.3	4.4	1.6	-1.6	-1.1	-0.9	-2.1	-1.5
Delay disc. indifference point, 8s delay	2.3	2.7	3.9	2.0	-2.0	-1.6	-1.6	-1.4	-1.2
Indifference point function ln k	1.2	2.1	2.8	-1.7	1.7	1.6	1.5	1.2	1.0
Indifference point function log k	1.2	2.1	2.8	-1.7	1.7	1.6	1.5	1.2	1.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.6	0.6	0.2	-0.1	0.6	0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.5	0.5	0.2	-0.1	0.1	-0.2
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.3	0.0	0.2
Patch foraging total patch changes 24 sec	0.3	0.5	1.3	0.6	-0.6	-0.9	-1.1	0.1	-0.2
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	0.1	-0.1	-0.4	-0.5	-0.1	0.3
Patch foraging time to switch 0 sec	0.2	0.5	2.3	-0.2	0.2	0.2	0.4	-1.5	-0.5
Patch foraging water rate 0 sec	0.9	1.9	4.8	-1.0	1.0	0.9	0.7	2.2	1.9
Patch foraging water rate 12 sec	0.1	0.3	1.5	-0.1	0.1	-0.1	-0.2	1.2	0.4
Patch foraging water rate 18 sec	1.1	1.7	5.5	-0.6	0.6	0.6	0.7	2.3	1.8
Patch foraging water rate 24 sec	2.9	4.1	5.9	-1.9	1.9	2.0	1.8	2.4	2.0
Patch foraging water rate 6 sec	0.4	0.6	2.7	0.1	-0.1	-0.2	-0.4	1.6	0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.3	1.1	-1.1	-0.7	-0.1	-0.2	0.0
Distance traveled before self-admin	0.9	1.2	4.5	0.6	-0.6	-0.6	-0.7	-2.1	-1.1
Distance traveled after self-admin	0.4	0.5	1.5	-0.4	0.5	0.7	0.7	0.5	1.2
Extensor digitorum longus weight	1.0	4.0	5.9	1.9	-1.9	-1.9	-1.8	-2.4	-2.0
Bone: elastic displacement	1.1	1.3	2.2	-0.9	0.9	0.9	1.4	0.9	1.5
Bone: elastic work	2.7	3.5	5.7	-2.1	2.1	1.8	2.4	0.6	1.6
Bone: endosteal estimation	1.6	3.4	5.2	-1.9	1.9	2.1	2.3	1.1	1.6
Bone: endosteal perimeter	1.5	3.3	5.5	-1.8	1.8	1.9	2.3	1.3	1.5
Epididymis fat weight	2.0	6.9	11.2	-3.3	3.3	2.9	2.2	1.7	1.6
Delta time in closed arm before/after self-admin	1.0	0.9	1.9	-0.3	0.2	-0.7	-1.1	-1.4	-1.2
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.6	-0.7	0.2	0.4	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.1	0.1	0.5	0.6	0.8	0.7
Delay discount exponential model param	4.2	4.6	6.1	-2.5	2.5	1.9	1.7	2.3	1.9
Extinction: sum of active levers before priming	1.2	1.3	2.2	1.1	-1.1	-0.8	-0.5	-1.5	-1.5
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.3	0.0	0.2	-0.2	-0.3
Bone: final force	0.5	0.7	1.2	-1.1	1.1	0.9	1.1	-0.1	0.3
Bone: final moment	0.7	1.1	1.8	-1.3	1.3	1.1	1.3	0.1	0.4
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.5	0.5	0.2	0.0	-0.5	-0.3
Glucose	0.1	0.2	0.5	-0.7	0.7	0.4	-0.1	0.1	0.3
Heart weight	4.8	7.4	9.4	-2.6	2.6	2.8	3.1	2.5	2.6
Delay discount hyperbolic model param	5.1	5.7	7.4	-2.6	2.6	2.1	2.0	2.7	2.3
Intermittent access intake day 1-15 change	0.1	0.2	0.5	0.1	-0.1	-0.4	-0.7	-0.2	-0.6
Intermittent access intake escalation	0.1	0.2	0.5	0.3	-0.3	-0.5	-0.7	-0.0	-0.5
Intermittent access intake escalation 2	0.1	0.1	0.3	0.3	-0.2	-0.4	-0.6	0.2	-0.1
Intermitt. access day 1 inactive lever presses	0.3	1.3	2.3	-1.1	1.1	1.1	1.1	0.7	1.5
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.2	0.2	0.0	-0.1	-0.2	0.4
Intermitt. access escalation Index	1.2	1.7	2.4	1.2	-1.2	-1.6	-1.5	-0.7	-1.5
Intermittent access day 1 total infusions	1.2	1.9	4.9	0.6	-0.6	-0.9	-1.2	-2.2	-1.8
Intermittent access day 15 total infusions	1.4	2.0	3.4	0.9	-0.9	-1.3	-1.5	-1.8	-1.8
Intermittent access terminal intake (last 3 days)	1.2	1.5	2.4	0.9	-0.9	-1.1	-1.2	-1.6	-1.6
Intermittent access total infusions	2.5	2.9	6.9	1.0	-1.0	-1.3	-1.5	-2.6	-2.1
Intermittent access day 1 locomotion	0.9	1.2	2.9	0.6	-0.6	-0.8	-1.0	-1.7	-1.2
Intermittent access day 15 total locomotion	0.2	0.4	1.2	-0.1	0.1	-0.2	-0.7	-1.1	-0.8
Intermittent access total locomotion	0.3	0.4	1.3	-0.4	0.4	-0.0	-0.6	-1.1	-0.6
Intermittent access standard deviation	0.4	0.8	1.6	-1.1	1.1	0.8	0.2	-1.3	-0.1
Left kidney weight	6.4	29.9	39.5	-6.3	6.3	6.3	5.9	3.2	4.0
Right kidney weight	8.6	39.2	54.0	-7.3	7.3	7.1	6.4	3.8	4.6
Cocaine induced anxiety	0.2	0.3	0.5	-0.6	0.6	0.7	0.5	-0.1	0.3
Post-drug Anxiety	0.7	0.8	1.5	-0.5	0.5	0.9	0.9	0.9	1.2
Baseline Anxiety	0.2	0.3	0.5	0.7	-0.7	-0.6	-0.4	0.3	-0.0
Tail length	0.6	2.3	4.8	-1.3	1.3	1.2	0.9	2.2	1.9
Length with tail	2.1	9.3	10.3	-3.2	3.2	3.1	2.6	3.2	2.9
Length without tail	3.4	11.0	14.7	-3.8	3.8	3.7	3.2	2.3	2.6
Times rat made contact with spout	0.7	0.7	1.5	0.6	-0.6	-0.9	-1.2	1.2	-0.2
Lifetime Intake	2.4	3.0	7.8	0.9	-0.9	-1.2	-1.5	-2.8	-2.2
Liver weight, left	0.1	0.2	0.3	-0.5	0.5	0.4	0.2	0.5	-0.0
Liver weight, right	2.0	3.6	6.8	-1.9	1.9	1.8	1.5	2.6	1.5
Locomotor activity	1.2	1.9	3.4	-1.9	1.9	1.6	1.1	1.0	0.3
Locomotor testing distance	0.1	0.2	0.6	-0.1	0.1	-0.2	-0.8	0.1	-0.8
Locomotor testing rearing	0.3	0.6	1.2	-1.1	1.1	0.8	0.4	0.4	-0.5
Locomotion in novel chamber	1.8	2.3	3.9	2.0	-1.9	-1.7	-1.5	-0.3	-0.9
Locomotion in novel chamber post-restriction	2.3	3.8	4.4	2.1	-2.1	-2.0	-2.0	-1.5	-1.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.1	-0.1	0.2	0.4	0.6	0.8
Change in fecal boli incidents, locomotor task	1.1	1.0	3.0	-1.0	1.0	0.7	0.6	1.7	0.7
Time >=10cm from walls, locomotor time 1	1.5	1.6	2.7	-1.6	1.6	1.2	1.2	0.5	1.0
Bouts of movement, locomotor time 1	0.2	0.3	0.5	-0.7	0.7	0.4	0.3	0.6	0.3
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.7	0.7	0.4	0.4	0.5	0.6
Rest time, locomotor task time 1	0.7	0.9	1.6	-1.0	1.0	0.7	0.8	0.8	1.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.2	0.2	0.5	0.3	0.4	-0.1
Vertical activity count, locomotor time 1	0.3	0.6	1.2	-0.6	0.6	0.9	0.3	1.1	0.9
Time >=10cm from walls, locomotor time 2	1.9	2.7	6.0	-1.1	1.1	0.9	1.5	2.2	2.4
Bouts of movement, locomotor time 2	1.9	3.1	5.7	1.3	-1.3	-1.5	-1.8	-2.1	-2.4
Total resting periods, locomotor time 2	2.2	3.8	7.0	1.4	-1.4	-1.7	-1.9	-2.4	-2.6
Rest time, locomotor task time 2	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.2	-0.4	-0.1
Distance moved, locomotor task time 2	0.9	1.1	2.1	-0.7	0.7	1.0	1.1	1.4	1.2
Vertical activity count, locomotor time 2	0.9	1.2	2.7	-0.6	0.6	1.0	0.8	1.6	1.5
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	-0.2
Light reinforcement 2	0.0	0.1	0.1	-0.3	0.3	0.2	0.2	-0.3	-0.3
Bone: marrow area	1.7	3.7	5.6	-2.0	2.0	2.2	2.4	1.1	1.7
Bone: maximum diameter	2.4	4.5	6.7	-2.3	2.3	2.6	2.4	1.1	1.6
Bone: maximum force	0.6	1.1	1.8	-1.3	1.3	1.1	1.2	-0.2	0.3
Bone: maximum moment	0.9	1.5	2.5	-1.6	1.6	1.4	1.4	-0.1	0.4
Mean time between licks in bursts	0.4	0.9	1.4	1.2	-1.2	-0.9	-0.1	-1.1	-0.6
Mean num. licks in bursts	0.4	0.6	0.9	-0.9	0.9	0.7	0.3	1.0	0.2
Cd content in liver	0.1	0.1	0.5	-0.3	0.3	-0.2	-0.3	0.1	-0.7
Co content in liver	0.6	0.7	1.3	0.6	-0.6	-1.1	-0.9	-0.8	-0.8
Cu content in liver	3.8	4.5	7.6	2.8	-2.8	-2.1	-2.2	-0.9	-1.2
Fe content in liver	5.8	7.0	9.4	-2.8	2.8	3.1	2.9	1.6	2.4
K content in liver	0.1	0.1	0.2	0.5	-0.5	-0.2	-0.3	0.1	0.0
Mg content in liver	0.1	0.1	0.1	0.3	-0.3	0.2	-0.2	0.3	0.2
Mn content in liver	0.6	0.7	0.9	0.9	-0.9	-0.7	-0.9	-0.4	-1.0
Na content in liver	0.1	0.1	0.4	-0.0	0.0	0.3	0.1	0.5	0.6
Rb content in liver	0.0	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.2	0.2
Se content in liver	0.5	0.6	0.8	0.9	-0.9	-0.8	-0.8	-0.1	-0.9
Sr content in liver	5.9	5.1	7.0	2.5	-2.5	-2.7	-2.4	-1.5	-1.8
Zn content in liver	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.5	0.3	-0.3
Bone: minimum diameter	0.2	0.4	0.8	-0.9	0.9	0.9	0.6	-0.2	0.0
Time in familiar zone, hab. session 1	0.2	0.2	0.6	0.2	-0.2	-0.4	0.5	0.6	0.8
Time in novel zone, hab. session 1	0.7	0.7	1.4	-1.2	1.2	1.1	0.6	0.2	0.2
Total zone transitions, hab. session 1	2.2	3.1	4.3	2.1	-2.1	-2.0	-1.9	-0.7	-1.4
Total locomotion distance, hab. session 1	0.6	0.9	1.5	1.0	-1.0	-1.1	-1.2	0.0	-0.8
Locomotion velocity, hab. session 1	0.9	1.3	2.0	1.3	-1.3	-1.2	-1.4	-0.2	-0.9
Time in familiar zone, hab. session 2	0.4	0.4	0.7	0.8	-0.8	-0.8	-0.3	0.6	0.2
Time in novel zone, hab. session 2	0.5	0.5	1.1	-0.6	0.6	0.6	-0.3	-1.0	-0.8
Total zone transitions, hab. session 2	0.4	0.5	0.8	0.9	-0.9	-0.9	-0.7	-0.1	0.1
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.5	-0.5	-0.5	-0.5	-0.7	-0.2
Locomotion velocity, hab. session 2	0.3	0.3	0.5	0.7	-0.7	-0.7	-0.5	-0.6	-0.0
Novel to familiar place preference ratio	1.6	1.7	2.7	-1.6	1.6	1.6	1.1	1.2	0.4
Novelty place preference	1.8	1.9	2.9	-1.7	1.7	1.7	1.1	1.4	0.4
Time in novel zone, NPP test	2.1	2.2	3.3	-1.8	1.8	1.8	1.1	1.5	0.5
Total zone transitions, NPP test	1.7	2.4	3.7	1.9	-1.9	-1.9	-1.7	-0.6	-0.9
Total locomotion distance, NPP test	0.2	0.3	0.5	0.7	-0.7	-0.7	-0.4	-0.2	-0.1
Locomotion velocity, NPP test	0.7	0.9	1.6	1.3	-1.3	-1.2	-0.8	-0.4	-0.4
Intraocular pressure	0.4	0.6	0.9	-0.9	0.9	0.9	0.8	0.4	0.4
Delta distance traveled before/after self-admin	3.7	4.0	8.4	-1.3	1.3	1.7	1.7	2.9	2.4
Delta ambulatory time before/after self-admin	3.0	3.7	7.9	-1.3	1.3	1.7	1.8	2.8	2.2
Parametrial fat weight	0.6	1.3	4.1	-0.6	0.6	0.6	0.6	2.0	1.5
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.5	0.5	0.7	0.3	0.0	0.1
Pavlov. Cond. magazine entry latency	1.3	1.7	2.8	1.4	-1.4	-1.7	-1.0	-1.4	-0.9
Pavlov. Cond. change in total contacts	2.2	2.3	2.7	1.6	-1.6	-1.6	-1.4	-1.5	-1.4
Pavlov. Cond. index score	0.4	0.5	1.2	0.8	-0.8	-1.1	-0.5	-0.5	-0.4
Pavlov. Cond. latency score	0.3	0.3	0.8	0.6	-0.6	-0.9	-0.4	-0.4	-0.3
Pavlov. Cond. lever contacts	0.6	0.7	1.4	1.0	-1.0	-1.2	-0.7	-0.3	-0.3
Pavlov. Cond. magazine entry number	1.4	1.8	2.8	-1.5	1.5	1.7	1.2	1.2	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	0.0	-0.0	0.4	-0.2	0.7	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.5	1.0	-1.0	-1.2	-0.7	-0.6	-0.5
Pavlov. Cond. response bias	1.0	1.3	2.3	1.3	-1.3	-1.5	-0.9	-0.9	-0.6
Pavlov. Cond. lever latency	0.2	0.2	0.8	0.3	-0.3	-0.1	-0.6	-0.2	-0.9
Pavlov. Cond. magazine entry latency	0.6	0.7	1.5	0.7	-0.7	-0.6	-0.9	-1.2	-0.6
Pavlov. Cond. change in total contacts	2.1	3.4	5.5	-1.8	1.8	1.6	2.2	0.8	2.4
Pavlov. Cond. index score	0.1	0.1	0.4	-0.2	0.2	0.1	0.3	-0.2	0.6
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.1	0.0	0.0	0.2	-0.1	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.9	-0.3	0.3	0.1	0.6	0.3	0.9
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	0.0	-0.0	-0.2	-0.1	0.2	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.2	0.2	0.2	0.1	0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	0.1	0.1	0.3	-0.3	0.6
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.1	0.1	0.1	0.4	-0.2	0.7
Time in closed arm before self-admin	0.3	0.4	0.7	0.9	-0.8	-0.6	-0.5	-0.6	0.1
Time in closed arm after self-admin	0.3	0.3	0.7	-0.8	0.9	0.1	-0.3	0.1	0.4
Time in open arm before self-admin	0.2	0.2	1.0	-0.2	0.1	0.1	0.2	1.0	0.5
Time in open arm after self-admin	0.4	0.4	1.1	1.0	-1.1	-0.4	-0.1	0.2	-0.2
Bone: periosteal estimation	1.2	2.5	3.6	-1.8	1.8	1.9	1.9	0.7	1.1
Bone: periosteal perimeter	2.8	4.9	6.4	-2.4	2.4	2.4	2.5	1.7	1.7
Bone: post-yield work	0.0	0.0	0.1	0.2	-0.2	-0.2	0.0	-0.4	-0.3
Progressive ratio test 1 active lever presses	1.4	1.8	4.7	0.7	-0.7	-1.0	-1.1	-2.2	-1.7
Progressive ratio test 1 breakpoint	1.3	1.6	4.0	0.7	-0.7	-1.0	-1.1	-2.0	-1.6
Progressive ratio test 1 inactive lever presses	1.5	2.1	7.7	0.9	-0.9	-1.0	-1.0	-2.8	-1.2
Progressive ratio test 2 active lever presses	2.4	2.8	4.7	1.1	-1.1	-1.5	-1.9	-2.2	-2.0
Progressive ratio test 2 breakpoint	2.9	3.3	5.5	1.3	-1.3	-1.6	-1.9	-2.3	-2.1
Progressive ratio test 2 inactive lever presses	2.6	4.3	5.7	1.9	-1.9	-2.1	-2.4	-2.0	-2.0
Incentive Sensitization - Responses	0.8	1.1	1.8	0.9	-0.9	-1.1	-1.4	-0.9	-1.1
Incentive Sensitization - Breakpoint	0.9	1.1	1.8	0.9	-0.9	-1.1	-1.3	-1.0	-1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.2	-0.2	0.2	0.2	-0.2	0.0
Progressive ratio	0.2	0.3	0.6	-0.8	0.8	0.4	0.3	-0.5	0.1
Food seeking constrained by brief footshock	0.3	0.4	1.0	-0.6	0.6	-0.3	-0.4	-0.7	-1.0
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.2	-0.2	-0.4	-0.3	-0.0	-0.3
Retroperitoneal fat weight	2.4	10.3	14.7	-3.8	3.8	3.6	3.2	2.2	2.1
Reaction time number correct	0.7	1.4	2.3	1.5	-1.5	-1.4	-1.1	0.3	-0.8
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.1	0.2	0.3	-0.1	0.3
Reaction time mean minus median AUC	0.1	0.3	0.5	-0.7	0.7	0.7	0.5	0.1	0.4
Reaction time num false alarms	0.1	0.2	0.3	-0.5	0.5	0.3	-0.2	0.2	-0.5
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.4	0.4	0.2	-0.3	0.1	-0.7
Reaction time trials correct on left	0.7	1.4	2.3	1.5	-1.5	-1.4	-1.1	0.3	-0.8
Reaction time trials on left	0.9	1.7	2.7	1.6	-1.6	-1.5	-1.2	0.2	-0.9
Reaction time mean	0.3	0.5	1.0	-0.6	0.6	0.7	0.8	0.3	1.0
Reaction time mean AUC	0.2	0.3	0.6	-0.4	0.4	0.5	0.6	0.2	0.8
Median of all reaction times	0.3	0.4	0.9	-0.5	0.5	0.6	0.8	0.3	1.0
Reaction time omissions	2.5	3.6	5.7	1.7	-1.7	-1.8	-1.6	-2.4	-2.1
Reaction time false alarm rate	0.3	0.4	0.9	-1.0	1.0	0.7	0.1	-0.1	-0.4
Reaction time premature initiation rate	0.3	0.4	0.7	-0.8	0.8	0.7	0.5	-0.3	0.2
Reaction time premature initiations	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1	-0.1	-0.0
Std. dev. reaction times	0.3	0.5	0.7	-0.8	0.8	0.8	0.7	0.4	0.8
Reaction time trials completed	0.9	1.7	2.7	1.6	-1.6	-1.5	-1.2	0.2	-0.9
Reaction time trials AUC	0.6	1.1	1.7	1.3	-1.3	-1.2	-1.0	0.3	-0.7
Run reversals in cocaine runway, females	0.8	0.8	1.8	-0.8	0.8	0.2	0.5	1.3	1.2
Run reversals in cocaine runway, males	0.4	0.5	0.8	-0.6	0.6	0.9	0.7	0.7	0.3
Latency to leave start box in cocaine runway	0.2	0.2	1.0	-0.1	0.1	0.6	1.0	-0.3	0.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.3	-0.2	0.2	0.8	-0.3	0.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.5	0.5	0.7	0.5	0.0	-0.1
Std. dev. time between licks in bursts	0.1	0.2	0.4	-0.1	0.1	0.3	0.6	0.3	0.6
Total sessions with >9 infusions	0.4	0.5	2.1	-0.3	0.3	0.2	0.1	-1.4	-0.8
Short access day 1 total inactive lever presses	1.6	2.1	2.7	-1.6	1.6	1.6	1.5	-0.0	1.5
Short access day 10 total inactive lever presses	1.5	3.7	6.2	-1.5	1.5	1.7	1.5	2.5	2.5
Short access day 1 total infusions	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	-0.3	0.4
Short access day 10 total infusions	0.4	0.5	1.9	-0.2	0.2	0.1	-0.1	-1.4	-0.9
Short access total infusions	0.7	0.9	3.4	0.1	-0.1	-0.3	-0.4	-1.8	-1.2
Short access day 1 locomotion	0.2	0.3	0.5	-0.4	0.4	0.7	0.5	-0.2	0.6
Short access day 10 total locomotion	0.1	0.2	0.4	-0.4	0.4	0.0	-0.4	-0.6	0.2
Short access total locomotion	0.2	0.3	1.2	-0.4	0.4	0.3	-0.1	-1.1	-0.1
One hour access (0.3 mA shock)	7.6	8.7	10.2	2.8	-2.7	-3.0	-3.1	-2.9	-3.2
Compulsive drug intake	0.7	0.8	1.3	1.1	-1.1	-1.1	-1.0	0.1	-0.2
One hour access (shock baseline)	1.8	2.8	5.1	1.3	-1.3	-1.3	-1.5	-2.3	-2.1
Social response proportion	0.4	0.5	2.0	-0.2	0.2	0.3	0.8	-1.4	-0.2
Social responses	0.3	0.4	1.3	0.3	-0.3	-0.4	-0.4	-1.2	-0.8
Social time	1.8	2.5	3.6	1.4	-1.4	-1.6	-1.5	-1.9	-1.5
Soleus weight	0.1	0.4	1.1	0.3	-0.3	-1.0	-1.0	0.1	0.3
Bone: stiffness	0.9	1.4	2.0	-1.4	1.4	1.3	1.3	0.3	0.9
Tibialis anterior weight	3.1	10.6	12.7	3.0	-3.0	-3.1	-3.6	-3.6	-3.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.5	-0.1	0.1	-0.1	-0.2	-0.7	-0.4
Time to tail flick, vehicle, after self-admin	0.9	1.2	2.6	-0.5	0.5	0.9	0.8	1.6	1.6
Time to tail flick, test, before self-admin	1.5	1.6	2.7	1.1	-1.1	-1.1	-1.4	-1.2	-1.6
Time to tail flick, test, after self-admin	0.5	0.5	1.0	1.0	-1.0	-0.5	-0.2	0.7	0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	-0.4	0.4	0.8	0.9	0.7	0.9
Delta time to tail flick, test, before/after SA	0.4	0.4	0.5	0.7	-0.7	-0.5	-0.3	0.7	0.7
Tibia length	0.4	1.1	1.6	-1.2	1.2	1.3	1.2	0.6	0.6
Ambulatory time before self-admin	0.8	1.2	3.2	0.8	-0.8	-0.8	-1.0	-1.8	-1.0
Ambulatory time after self-admin	0.2	0.3	0.7	-0.2	0.2	0.3	0.3	0.8	0.9
Bone: tissue strength	0.6	0.6	1.0	-0.9	0.9	1.0	0.7	0.3	0.5
Total heroin consumption	1.3	1.5	3.3	0.9	-0.9	-0.9	-1.1	-1.5	-1.8
Bone: trabecular number	0.1	0.1	0.4	-0.0	0.0	-0.0	0.2	0.6	0.3
Bone: trabecular spacing	0.6	0.7	1.1	-0.9	0.9	0.9	0.8	0.4	1.1
Bone: trabecular thickness	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.1	-0.2
Bone: trabecular tissue density	0.1	0.1	0.3	0.2	-0.2	0.0	-0.2	0.5	0.5
Water consumed over 24 hours	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.6	0.5	-0.2
Number of responses in last shaping day	3.3	3.6	8.9	1.5	-1.5	-1.4	-1.5	-3.0	-2.1