Slc16a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Slc16a6	0.05	0.02	5.9e-06	0.07	0.05	0.05	0.06	4.4e-08	4.6e-06	3.6e-06	4.0e-07
2	OFC	gene expression	Slc16a6	0.31	0.14	3.6e-04	0.14	0.14	0.13	0.13	2.8e-04	3.4e-04	5.3e-04	4.5e-04
3	Adipose	alternative TSS	XM_006247619.4	0.04	0.03	9.8e-03	0	0	0	0	7.8e-02	1.0e-01	3.0e-01	1.0e-01
4	Adipose	alternative TSS	XM_006247619.4	0.04	0.03	7.9e-03	0	0	-0	0	1.2e-01	1.4e-01	4.0e-01	1.8e-01
5	Adipose	gene expression	Slc16a6	0.1	0.05	2.7e-12	0.07	0.1	0.1	0.09	2.0e-08	5.3e-11	9.8e-11	3.3e-10
6	NAcc	gene expression	Slc16a6	0.03	0.02	1.2e-03	0.01	0.01	0.01	0.01	5.6e-02	7.0e-03	5.4e-02	2.2e-02
7	LHb	gene expression	Slc16a6	0.3	0.13	1.1e-04	0.12	0.13	0.07	0.13	9.2e-04	6.0e-04	1.2e-02	4.5e-04
8	Brain	gene expression	Slc16a6	0.39	0.11	0.0e+00	0.42	0.42	0.43	0.43	2.0e-42	1.6e-41	9.6e-44	3.4e-43
9	Liver	gene expression	Slc16a6	0.16	0.07	5.6e-17	0.15	0.12	0.13	0.05	5.0e-16	4.8e-13	3.0e-14	1.5e-06
10	Brain	alternative TSS	XM_039086231.1	0.03	0.02	4.4e-03	0.04	0.02	0.03	-0	5.6e-05	5.0e-03	1.1e-03	3.7e-01
11	Brain	alternative TSS	XM_006247619.4	0.08	0.04	3.8e-08	0.1	0.08	0.07	0.09	1.5e-09	8.0e-08	3.8e-07	6.1e-09
12	Brain	alternative TSS	XM_006247619.4	0.08	0.04	3.2e-07	0.09	0.07	0.05	0.08	1.5e-08	5.2e-07	1.0e-05	1.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	4.2	7.0	9.7	2.9	3.1	0.4	0.4	-3.1	-3.1	-2.5	2.8	-2.8	-2.3	3.1	3.1
Area under the delay curve	0.1	0.1	0.3	0.5	-0.0	0.1	0.1	-0.1	-0.0	0.1	-0.3	0.4	-0.0	-0.4	-0.4
BMI with tail	5.3	17.1	28.8	-3.7	-3.7	-2.3	-2.3	4.3	4.1	4.8	-5.0	4.9	5.4	-4.0	-4.0
BMI without tail	5.1	10.6	18.5	-2.4	-2.1	-3.5	-3.5	2.6	1.8	4.3	-3.7	3.5	3.9	-3.3	-3.3
Body weight	4.8	20.2	35.8	-3.0	-3.0	-1.9	-1.9	4.4	4.2	5.5	-5.9	5.9	6.0	-4.8	-4.8
Weight adjusted by age	4.2	4.7	8.3	-2.0	-1.8	0.6	0.6	2.3	2.9	1.9	-2.4	2.3	2.6	-2.6	-2.6
Bone surface	4.6	8.2	15.9	4.0	3.7	0.1	0.1	-3.8	-3.8	-2.4	2.7	-2.6	-2.3	2.7	2.7
Bone volume	3.9	6.6	13.7	3.7	3.6	-0.2	-0.2	-3.6	-3.6	-1.9	2.2	-2.1	-1.9	2.3	2.3
Breakpoint value in progressive ratio session	1.2	1.3	3.3	-1.3	-1.8	-0.4	-0.4	1.5	1.4	0.7	-0.9	1.0	0.8	-1.2	-1.2
Number of licking bursts	0.1	0.1	0.2	0.3	0.2	0.1	0.1	0.2	0.3	-0.0	-0.4	0.5	0.4	-0.3	-0.3
Context. condit. distance diff. score	0.1	0.1	0.3	-0.1	-0.4	0.5	0.5	0.3	0.4	0.0	-0.3	0.2	0.2	-0.6	-0.6
Locomotion velocity, session 1	0.2	0.2	0.6	0.1	-0.8	-0.8	-0.8	0.1	-0.1	0.4	-0.3	0.2	-0.0	-0.0	-0.0
Locomotion distance, session 1	0.4	0.5	2.4	-0.1	-0.9	-1.5	-1.5	0.0	-0.2	0.8	-0.3	0.3	-0.1	-0.2	-0.2
Locomotion velocity, session 2	0.7	0.8	2.9	-0.0	-0.2	-1.7	-1.7	-0.5	-1.0	0.2	0.4	-0.4	-0.9	0.7	0.7
Locomotion distance, session 2	0.6	0.8	3.4	-0.4	-0.6	-1.8	-1.8	-0.3	-0.7	0.6	0.2	-0.2	-0.6	0.7	0.7
Locomotion velocity, session 3	2.0	2.4	5.1	-1.9	-1.9	-2.3	-2.3	1.4	1.1	1.5	-1.0	1.0	0.9	-1.1	-1.1
Locomotion distance, session 3	0.1	0.1	0.3	0.5	0.4	-0.3	-0.3	-0.4	-0.3	-0.3	0.2	-0.3	-0.3	-0.0	-0.0
Stereotopy head waving bouts, day 3	0.8	0.9	2.3	-1.5	-1.5	0.4	0.4	0.6	0.5	-0.8	0.9	-0.8	-1.3	1.0	1.0
Stereotopy head waving duration, day 3	0.4	0.5	1.1	-0.9	-1.1	-0.2	-0.2	0.2	0.2	-0.5	0.8	-0.7	-1.1	0.9	0.9
Locomotion velocity, session 7	0.1	0.1	0.3	0.2	0.1	-0.4	-0.4	-0.3	-0.4	-0.3	0.4	-0.6	-0.4	0.4	0.4
Locomotion distance, session 7	0.5	0.6	1.5	1.2	1.2	-0.4	-0.4	-1.2	-1.2	-0.3	0.6	-0.6	-0.4	0.2	0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	-0.7	-0.2	-0.0	-0.0	0.2	0.1	-0.5	0.7	-0.7	-0.5	0.8	0.8
Stereotopy head waving duration, day 7	0.7	0.9	1.9	-0.6	-0.3	0.4	0.4	0.1	0.1	-1.2	1.2	-1.3	-1.0	1.4	1.4
Locomotion velocity, session 8	0.0	0.0	0.1	-0.2	-0.1	0.3	0.3	-0.1	-0.0	0.1	-0.2	0.1	-0.3	0.0	0.0
Locomotion distance, session 8	0.3	0.5	2.2	-0.3	-0.6	-1.5	-1.5	-0.2	-0.5	0.7	-0.2	0.1	-0.2	-0.1	-0.1
Degree of sensitization distance	0.1	0.1	0.6	0.3	0.4	-0.2	-0.2	-0.6	-0.8	0.2	0.2	-0.1	-0.2	0.2	0.2
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.5	-0.1	-0.4	-0.4	0.4	0.2	-0.0	0.2	-0.2	0.1	0.3	0.3
Conditioned locomotion	0.3	0.4	1.0	0.6	0.4	-0.9	-0.9	-0.7	-1.0	-0.3	0.5	-0.5	-0.6	0.4	0.4
Cocaine response after cond. corrected	0.5	0.6	2.6	1.2	1.6	0.8	0.8	-0.9	-0.7	-0.5	0.2	-0.2	0.1	0.2	0.2
Cocaine response after cond. not corrected	0.6	0.7	3.0	1.4	1.7	0.7	0.7	-1.0	-0.8	-0.6	0.3	-0.3	-0.1	0.3	0.3
Cocaine response before conditioning	0.2	0.2	0.9	-0.2	-0.5	-1.0	-1.0	-0.1	-0.3	0.1	0.1	-0.1	-0.5	0.1	0.1
Saline control response	4.8	6.2	8.5	-2.3	-2.7	-2.4	-2.4	2.4	2.1	2.9	-2.6	2.6	2.2	-2.7	-2.7
Bone: connectivity density	5.4	8.4	12.8	2.6	2.5	-0.0	-0.0	-3.1	-3.3	-2.9	3.5	-3.5	-3.0	3.6	3.6
Bone: cortical apparent density	1.2	1.6	5.6	-2.4	-2.2	0.4	0.4	1.9	1.7	0.7	-0.8	0.8	0.2	-0.5	-0.5
Bone: cortical area	1.2	1.8	6.4	-0.1	-0.6	-2.5	-2.5	0.0	-0.5	1.6	-1.2	1.2	0.9	-0.9	-0.9
Bone: cortical porosity	0.8	0.9	2.4	1.3	1.3	-1.3	-1.3	-1.2	-1.5	0.3	0.1	-0.1	0.2	-0.0	-0.0
Bone: cortical porosity	0.8	0.9	2.0	1.0	1.1	-1.4	-1.4	-0.7	-1.0	0.9	-0.5	0.6	0.8	-0.6	-0.6
Bone: cortical thickness	5.5	9.0	17.7	-4.0	-4.2	-2.7	-2.7	3.5	2.8	3.0	-2.8	2.8	2.2	-2.3	-2.3
Bone: cortical thickness	1.0	1.1	3.9	-1.8	-2.0	-1.3	-1.3	1.3	0.7	0.7	-0.4	0.4	0.1	-0.1	-0.1
Bone: cortical tissue density	1.2	1.5	5.4	-2.3	-2.1	0.4	0.4	1.9	1.6	0.6	-0.8	0.8	0.2	-0.5	-0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.3	0.6	0.0	-0.8	-0.8	-0.2	-0.5	1.1	-1.0	1.1	0.7	-0.7	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.8	0.9	-0.0	0.6	0.6	-0.3	-0.3	-0.3	0.0	0.1	-0.1	-0.1	-0.1
Condit. Reinf. active responses	0.6	0.8	2.0	0.7	0.3	-1.4	-1.4	-0.6	-1.0	1.2	-0.8	0.8	0.5	-0.5	-0.5
Condit. Reinf. inactive responses	0.8	0.9	4.1	0.3	0.5	-2.0	-2.0	-0.8	-1.1	0.8	-0.1	0.0	-0.0	0.1	0.1
Incentive salience index mean	0.2	0.3	0.7	0.3	0.0	-0.5	-0.5	-0.1	-0.4	0.9	-0.7	0.7	0.5	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.3	0.7	-0.7	-0.6	-0.2	-0.2	0.7	0.5	0.8	-0.7	0.6	0.7	-0.5	-0.5
Condit. Reinf. active minus inactive responses	2.2	2.8	6.9	2.3	2.1	-2.1	-2.1	-2.2	-2.6	-0.0	0.6	-0.6	-0.8	0.9	0.9
Condit. Reinf. active-inactive response ratio	2.1	2.2	6.1	2.5	2.3	-0.7	-0.7	-2.2	-2.3	-0.6	0.9	-0.8	-1.0	1.0	1.0
Condit. Reinf. active responses	2.5	3.5	8.6	2.2	2.1	-2.9	-2.9	-2.3	-2.9	0.4	0.4	-0.5	-0.7	0.7	0.7
Condit. Reinf. inactive responses	1.5	1.9	10.0	-0.1	-0.2	-3.2	-3.2	-0.5	-1.1	1.1	-0.3	0.1	-0.0	-0.2	-0.2
Condit. Reinf. lever presses	1.1	1.5	6.8	0.6	0.2	-2.6	-2.6	-0.5	-1.1	1.2	-0.7	0.5	0.5	-0.3	-0.3
Condit. Reinf. lever reinforcers received	2.0	2.9	7.1	2.1	1.8	-2.7	-2.7	-2.1	-2.6	0.4	0.3	-0.4	-0.6	0.4	0.4
Conditioned reinforcement - actives	2.2	2.2	4.3	0.6	1.0	-0.3	-0.3	-1.4	-1.5	-1.4	1.9	-2.1	-1.8	1.9	1.9
Conditioned reinforcement - inactives	0.1	0.1	0.8	0.2	0.9	-0.4	-0.4	-0.5	-0.4	0.2	-0.0	-0.1	-0.1	0.3	0.3
Conditioned locomotion	0.7	0.9	2.6	1.6	1.4	-0.8	-0.8	-1.4	-1.4	0.1	0.3	-0.3	-0.3	0.1	0.1
Patch foraging indifference point 0 sec	3.7	5.9	17.7	-1.0	-0.6	-4.2	-4.2	0.8	-0.0	3.5	-2.4	2.4	1.8	-1.9	-1.9
Patch foraging indifference point AUC	0.6	0.7	2.2	-0.0	-0.7	-0.3	-0.3	0.4	0.4	0.7	-1.0	1.3	0.1	-1.5	-1.5
Delay disc. indifference point, 0s delay	0.4	0.4	1.7	0.8	0.4	1.3	1.3	-0.3	0.0	-0.7	0.3	-0.3	-0.1	0.3	0.3
Delay disc. indifference point, 16s delay	0.6	0.7	1.4	-0.2	-0.8	-0.1	-0.1	0.7	0.7	0.8	-1.1	1.2	0.7	-1.1	-1.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.9	0.7	0.1	0.1	-0.5	-0.3	-0.3	0.1	0.0	-0.3	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.3	0.3	1.1	0.8	0.5	-1.0	-1.0	-0.5	-0.7	0.4	-0.2	0.3	-0.0	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.4	-0.2	0.6	0.6	-0.0	0.0	-0.3	-0.1	0.2	-0.2	0.1	0.1
Delay disc. indifference point, 8s delay	0.5	0.6	2.0	-0.6	-1.4	0.6	0.6	0.9	1.1	0.0	-0.5	0.7	0.1	-0.6	-0.6
Indifference point function ln k	1.3	1.8	5.3	0.1	0.3	-2.3	-2.3	-1.0	-1.4	-0.2	1.3	-1.5	-1.0	1.3	1.3
Indifference point function log k	1.3	1.8	5.3	0.1	0.3	-2.3	-2.3	-1.0	-1.4	-0.2	1.3	-1.5	-1.0	1.3	1.3
Patch foraging total patch changes 0 sec	3.7	5.9	17.3	-1.2	-0.7	-4.2	-4.2	0.9	0.0	3.5	-2.4	2.4	1.9	-1.8	-1.8
Patch foraging total patch changes 12 sec	1.6	2.0	4.9	0.4	-0.2	-2.2	-2.2	0.1	-0.4	1.8	-1.5	1.8	0.8	-1.5	-1.5
Patch foraging total patch changes 18 sec	3.8	4.8	8.0	-1.6	-1.5	-2.6	-2.6	1.6	1.2	2.8	-2.5	2.8	1.6	-2.3	-2.3
Patch foraging total patch changes 24 sec	2.3	2.8	10.0	-0.1	-0.2	-3.2	-3.2	0.0	-0.5	2.1	-1.5	1.7	0.6	-1.4	-1.4
Patch foraging total patch changes 6 sec	3.9	5.8	10.5	-0.3	-0.9	-3.0	-3.0	1.0	0.5	3.2	-2.9	3.2	2.0	-2.9	-2.9
Patch foraging time to switch 0 sec	0.9	1.4	7.1	0.3	0.9	2.7	2.7	0.1	0.5	-0.8	-0.1	0.0	0.3	0.7	0.7
Patch foraging water rate 0 sec	1.8	2.8	10.0	-0.5	-1.2	-3.2	-3.2	0.5	-0.3	2.1	-1.2	1.4	0.8	-1.3	-1.3
Patch foraging water rate 12 sec	1.4	2.1	4.0	-1.4	-2.0	-1.6	-1.6	1.5	1.3	1.6	-1.4	1.4	1.3	-1.2	-1.2
Patch foraging water rate 18 sec	0.3	0.5	1.5	-0.5	-0.2	-1.2	-1.2	-0.2	-0.6	0.1	0.5	-0.6	-0.2	0.8	0.8
Patch foraging water rate 24 sec	0.5	0.7	2.0	-0.1	-0.5	-1.4	-1.4	-0.4	-0.7	-0.2	0.8	-0.7	-0.6	1.1	1.1
Patch foraging water rate 6 sec	0.3	0.4	1.7	-0.7	-1.3	-1.0	-1.0	0.7	0.3	0.4	-0.2	0.3	0.1	-0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	3.7	-1.0	-1.5	-0.1	-0.1	1.4	1.4	1.6	-1.8	1.8	1.8	-1.9	-1.9
Distance traveled before self-admin	0.2	0.3	0.8	0.1	-0.4	0.9	0.9	0.3	0.6	-0.0	-0.5	0.5	0.4	-0.3	-0.3
Distance traveled after self-admin	0.2	0.3	0.4	0.1	-0.6	0.5	0.5	0.4	0.6	0.1	-0.7	0.6	0.5	-0.5	-0.5
Extensor digitorum longus weight	1.4	5.6	15.5	-1.8	-1.9	1.6	1.6	3.1	3.9	1.2	-2.5	2.5	2.6	-2.2	-2.2
Bone: elastic displacement	0.7	0.8	3.9	-0.9	-1.0	-2.0	-2.0	0.5	0.1	0.5	0.1	0.0	-0.1	0.2	0.2
Bone: elastic work	1.0	1.3	5.4	-0.5	-1.0	-2.3	-2.3	0.7	0.3	0.9	-0.5	0.5	0.8	-0.4	-0.4
Bone: endosteal estimation	3.7	8.0	31.8	5.6	4.9	-0.0	-0.0	-4.3	-4.1	-1.1	1.0	-1.0	-0.8	0.7	0.7
Bone: endosteal perimeter	4.1	8.4	32.1	5.7	4.7	-0.6	-0.6	-4.5	-4.5	-0.9	1.2	-1.1	-0.9	0.8	0.8
Epididymis fat weight	6.4	15.0	23.5	-2.9	-2.8	1.2	1.2	4.5	4.8	3.2	-4.5	4.7	4.8	-4.5	-4.5
Delta time in closed arm before/after self-admin	2.9	2.8	3.8	1.7	1.6	1.0	1.0	-1.9	-1.6	-1.9	1.9	-2.0	-1.7	1.8	1.8
Delta time in open arm before/after self-admin	0.3	0.3	0.8	-0.6	0.1	-0.2	-0.2	-0.1	-0.1	-0.6	0.8	-0.8	-0.9	0.5	0.5
Diff in mean of infusions in LGA sessions	1.1	1.2	2.1	-1.1	-1.2	-0.1	-0.1	1.3	1.4	1.0	-1.3	1.4	1.2	-1.1	-1.1
Delay discount exponential model param	0.1	0.1	0.6	-0.8	-0.3	-0.0	-0.0	0.3	0.2	-0.0	0.3	-0.4	0.0	0.3	0.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	0.2	0.2	0.2	0.2	0.1	0.2	-0.4	0.4	0.4	-0.4	-0.4
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.1	0.2	-0.1	-0.1	0.1	0.0	0.5	-0.4	0.4	0.6	-0.0	-0.0
Bone: final force	0.3	0.4	1.9	1.4	0.6	-0.7	-0.7	-0.8	-1.1	-0.2	0.1	-0.1	-0.3	0.0	0.0
Bone: final moment	0.3	0.5	1.9	1.4	0.6	-0.8	-0.8	-0.9	-1.1	-0.2	0.2	-0.1	-0.4	0.1	0.1
Food consumed during 24 hour testing period	4.0	4.9	7.8	-2.6	-2.6	-0.8	-0.8	2.8	2.4	2.2	-2.4	2.3	2.2	-2.1	-2.1
Glucose	0.0	0.1	0.4	0.1	-0.2	0.3	0.3	0.1	0.6	-0.1	-0.1	0.1	0.4	-0.2	-0.2
Heart weight	1.0	1.5	3.3	0.5	1.0	-1.8	-1.8	-0.5	-0.5	1.6	-1.2	1.2	1.5	-0.9	-0.9
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.6	-0.2	-0.1	-0.1	0.2	0.1	-0.1	0.3	-0.4	0.0	0.4	0.4
Intermittent access intake day 1-15 change	0.1	0.1	0.7	0.8	-0.0	0.4	0.4	-0.2	-0.2	0.1	-0.3	0.3	0.3	0.3	0.3
Intermittent access intake escalation	0.2	0.2	0.9	0.9	0.2	0.8	0.8	-0.3	-0.1	-0.2	-0.2	0.2	0.2	0.3	0.3
Intermittent access intake escalation 2	0.7	0.6	2.7	1.6	0.7	0.9	0.9	-0.7	-0.8	-0.6	0.2	-0.1	-0.3	0.8	0.8
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.9	-0.1	0.2	-1.4	-1.4	-0.0	-0.3	0.8	-0.4	0.4	0.3	-0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.8	-0.7	-0.4	0.9	0.9	0.7	0.9	0.6	-0.9	0.8	0.9	-0.2	-0.2
Intermitt. access escalation Index	0.3	0.3	0.4	0.6	0.4	0.0	0.0	-0.4	-0.6	-0.6	0.6	-0.5	-0.6	0.7	0.7
Intermittent access day 1 total infusions	0.6	0.6	3.1	-0.8	-0.5	-1.8	-1.8	-0.0	-0.3	0.8	-0.1	-0.1	0.1	0.1	0.1
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.6	0.1	-0.5	-0.5	-0.4	-0.6	0.5	-0.3	0.1	0.3	0.5	0.5
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.1	1.1	0.4	-0.1	-0.1	-0.8	-1.0	0.0	0.1	-0.2	-0.1	0.9	0.9
Intermittent access total infusions	0.3	0.4	1.8	-0.0	-0.4	-1.3	-1.3	-0.2	-0.6	0.6	-0.1	-0.1	0.0	0.2	0.2
Intermittent access day 1 locomotion	0.4	0.5	1.3	-0.1	-0.0	-1.1	-1.1	-0.2	-0.3	1.1	-0.7	0.5	0.8	-0.1	-0.1
Intermittent access day 15 total locomotion	0.6	0.7	2.0	1.2	1.4	-0.6	-0.6	-1.2	-1.3	0.2	0.1	-0.2	-0.1	0.6	0.6
Intermittent access total locomotion	0.9	1.0	2.8	0.1	-0.2	-1.7	-1.7	-0.1	-0.4	1.6	-1.1	0.9	1.1	-0.5	-0.5
Intermittent access standard deviation	0.2	0.2	0.6	0.8	-0.1	-0.5	-0.5	-0.5	-0.3	0.4	-0.4	0.5	0.3	-0.2	-0.2
Left kidney weight	0.6	1.7	3.5	-1.2	-0.5	-1.7	-1.7	0.8	0.6	1.9	-1.5	1.4	1.8	-0.8	-0.8
Right kidney weight	0.3	0.7	3.7	0.1	0.1	-0.6	-0.6	0.3	0.1	1.2	-1.2	1.0	1.9	-0.2	-0.2
Cocaine induced anxiety	1.2	1.3	1.9	0.9	1.4	1.1	1.1	-1.1	-0.8	-1.4	1.2	-1.3	-1.1	1.1	1.1
Post-drug Anxiety	1.2	1.4	3.6	1.1	1.4	1.9	1.9	-0.8	-0.4	-1.3	0.8	-0.8	-0.9	0.8	0.8
Baseline Anxiety	0.6	0.7	1.5	-1.1	-0.9	0.3	0.3	1.2	1.2	0.5	-0.7	0.8	0.6	-0.7	-0.7
Tail length	0.4	1.1	2.4	0.4	0.6	-0.9	-0.9	0.4	0.1	1.3	-1.1	1.1	1.2	-1.6	-1.6
Length with tail	0.5	2.0	4.8	0.2	0.2	0.0	0.0	1.1	1.1	1.6	-2.0	2.2	1.8	-1.8	-1.8
Length without tail	0.5	1.1	4.4	0.1	-0.2	2.1	2.1	0.9	1.5	-0.3	-0.7	0.8	0.5	-0.4	-0.4
Times rat made contact with spout	0.6	0.7	1.2	-0.4	-0.8	-1.0	-1.0	0.8	0.5	0.9	-1.0	0.9	1.1	-0.8	-0.8
Lifetime Intake	0.7	0.8	4.0	-0.3	-0.3	-2.0	-2.0	-0.3	-0.7	0.8	-0.1	-0.1	0.0	0.2	0.2
Liver weight, left	0.2	0.3	0.8	0.4	-0.1	0.0	0.0	-0.5	-0.7	-0.9	0.8	-0.8	-0.8	0.5	0.5
Liver weight, right	0.4	0.7	2.2	-1.1	-1.5	1.0	1.0	1.2	1.0	-0.2	-0.2	0.3	0.3	-0.3	-0.3
Locomotor activity	1.4	2.2	6.7	-0.6	-0.9	-2.6	-2.6	0.5	-0.1	1.8	-1.2	1.2	0.9	-1.4	-1.4
Locomotor testing distance	1.8	3.0	11.1	-0.5	-1.2	-3.3	-3.3	0.4	-0.2	2.1	-1.3	1.3	0.7	-1.2	-1.2
Locomotor testing rearing	2.8	4.3	8.2	-1.2	-2.1	-2.9	-2.9	1.6	1.0	2.5	-2.2	2.2	1.3	-2.0	-2.0
Locomotion in novel chamber	0.6	0.7	1.8	-0.5	-0.8	1.3	1.3	0.8	1.1	0.2	-0.7	0.6	0.9	-0.7	-0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.5	-0.2	-0.3	-0.4	-0.4	0.1	-0.1	0.2	-0.0	-0.1	0.1	0.7	0.7
Fecal boli incidents, locomotor time 1	0.9	1.0	3.4	1.5	1.8	0.5	0.5	-1.4	-1.1	-0.7	0.7	-0.7	-0.6	0.6	0.6
Change in fecal boli incidents, locomotor task	0.4	0.3	1.0	-0.2	-1.0	0.2	0.2	0.7	0.6	0.2	-0.6	1.0	-0.1	-0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	-0.9	-0.1	-0.7	-0.7	-0.1	-0.0	0.0	0.5	-0.6	-0.6	0.2	0.2
Bouts of movement, locomotor time 1	0.6	0.7	1.2	-0.9	-0.5	-0.1	-0.1	1.0	0.9	1.0	-1.1	1.1	1.1	-0.7	-0.7
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.4	-0.0	0.5	0.5	0.5	0.5	0.4	-0.6	0.6	0.7	-0.2	-0.2
Rest time, locomotor task time 1	0.2	0.2	1.0	0.2	0.2	1.0	1.0	0.0	0.5	-0.7	0.3	-0.1	-0.2	-0.2	-0.2
Distance moved, locomotor task time 1	1.4	1.5	3.0	-1.7	-1.7	-0.0	-0.0	1.7	1.5	1.0	-1.3	1.2	0.9	-1.0	-1.0
Vertical activity count, locomotor time 1	1.0	1.0	2.1	-1.5	-1.4	-0.0	-0.0	1.4	1.1	1.0	-1.1	1.1	0.6	-0.8	-0.8
Time >=10cm from walls, locomotor time 2	2.8	3.0	6.0	-2.4	-2.3	0.0	0.0	2.3	2.3	1.5	-1.7	1.7	1.7	-1.2	-1.2
Bouts of movement, locomotor time 2	3.7	4.0	5.3	-2.1	-2.1	-0.8	-0.8	2.3	2.3	2.0	-2.2	2.2	2.0	-2.2	-2.2
Total resting periods, locomotor time 2	2.9	3.1	4.4	-1.7	-1.9	-0.8	-0.8	1.9	2.0	1.8	-1.9	1.9	1.6	-2.1	-2.1
Rest time, locomotor task time 2	2.5	2.8	5.4	1.0	1.5	2.2	2.2	-1.2	-0.5	-2.3	1.9	-1.8	-1.9	1.2	1.2
Distance moved, locomotor task time 2	3.7	4.3	9.2	-2.9	-3.0	0.0	0.0	3.0	2.6	1.7	-2.0	1.9	2.0	-1.5	-1.5
Vertical activity count, locomotor time 2	2.6	2.8	4.8	-2.0	-2.2	-1.0	-1.0	2.1	1.4	2.0	-1.9	1.9	1.8	-1.1	-1.1
Light reinforcement 1	1.4	2.5	4.9	-1.8	-2.0	-2.2	-2.2	1.5	0.9	1.8	-1.2	1.3	0.7	-1.2	-1.2
Light reinforcement 2	0.1	0.2	0.3	-0.3	-0.6	-0.5	-0.5	0.3	0.4	0.3	-0.2	0.1	0.2	-0.4	-0.4
Bone: marrow area	3.6	7.9	31.2	5.6	4.8	0.1	0.1	-4.2	-4.1	-1.2	1.1	-1.1	-0.9	0.8	0.8
Bone: maximum diameter	1.7	3.1	9.7	3.1	2.4	-0.7	-0.7	-2.8	-2.8	-0.7	1.0	-0.9	-1.0	0.9	0.9
Bone: maximum force	0.5	0.8	2.8	1.7	1.1	-1.1	-1.1	-1.3	-1.5	0.2	-0.1	0.0	0.0	-0.0	-0.0
Bone: maximum moment	0.5	0.9	2.8	1.7	1.0	-1.2	-1.2	-1.3	-1.5	0.1	-0.0	-0.0	-0.1	-0.0	-0.0
Mean time between licks in bursts	0.5	0.7	1.8	0.2	0.1	0.9	0.9	0.6	1.0	0.4	-0.9	0.8	1.4	-0.9	-0.9
Mean num. licks in bursts	0.2	0.2	0.5	-0.6	-0.6	-0.7	-0.7	0.2	-0.0	0.5	-0.1	0.1	0.1	-0.2	-0.2
Cd content in liver	2.3	2.5	4.1	1.1	0.9	1.8	1.8	-1.0	-0.6	-2.0	1.8	-1.7	-1.6	1.9	1.9
Co content in liver	0.5	0.6	2.2	0.7	0.9	1.5	1.5	-0.3	0.1	-0.7	0.4	-0.6	-0.1	0.5	0.5
Cu content in liver	0.6	0.7	1.2	0.9	1.0	0.5	0.5	-1.1	-1.0	-0.7	0.7	-0.8	-0.7	1.1	1.1
Fe content in liver	0.2	0.3	0.8	0.5	-0.1	-0.4	-0.4	-0.5	-0.6	-0.5	0.7	-0.6	-0.9	0.3	0.3
K content in liver	1.9	1.8	2.9	1.1	1.2	-0.1	-0.1	-1.4	-1.7	-1.3	1.6	-1.6	-1.6	1.6	1.6
Mg content in liver	3.4	3.5	5.8	1.1	1.2	0.1	0.1	-1.7	-2.0	-2.0	2.4	-2.4	-2.3	2.4	2.4
Mn content in liver	3.6	4.0	6.2	1.5	1.5	-0.3	-0.3	-2.0	-2.3	-2.0	2.5	-2.5	-2.3	2.5	2.5
Na content in liver	0.6	0.6	1.3	0.4	0.4	0.3	0.3	-0.7	-0.6	-1.1	1.0	-1.0	-1.1	0.7	0.7
Rb content in liver	0.8	1.0	2.0	0.2	-0.4	1.4	1.4	-0.2	0.1	-1.3	1.1	-1.0	-1.4	0.9	0.9
Se content in liver	0.1	0.1	0.3	-0.4	-0.1	0.0	0.0	0.1	0.2	-0.4	0.5	-0.5	-0.3	0.5	0.5
Sr content in liver	0.8	0.7	1.9	-0.2	0.3	-1.1	-1.1	0.1	0.1	1.4	-1.1	0.9	1.1	-0.8	-0.8
Zn content in liver	2.0	2.2	4.3	0.8	1.3	-0.7	-0.7	-1.6	-1.8	-1.0	1.5	-1.8	-1.3	2.1	2.1
Bone: minimum diameter	2.1	3.9	13.5	3.7	3.2	-1.4	-1.4	-2.9	-3.1	0.5	-0.2	0.2	0.4	-0.0	-0.0
Time in familiar zone, hab. session 1	0.4	0.3	1.2	1.1	0.9	0.7	0.7	-0.7	-0.5	-0.1	-0.0	-0.1	-0.1	-0.3	-0.3
Time in novel zone, hab. session 1	0.3	0.3	1.0	-0.9	-0.4	-1.0	-1.0	0.5	0.1	0.3	0.0	0.0	0.2	0.3	0.3
Total zone transitions, hab. session 1	0.9	1.3	2.6	-1.0	-1.1	-1.1	-1.1	1.1	0.8	1.6	-1.3	1.1	1.5	-0.8	-0.8
Total locomotion distance, hab. session 1	1.5	2.1	3.3	-1.6	-1.8	-1.5	-1.5	1.4	0.9	1.8	-1.4	1.3	1.2	-1.3	-1.3
Locomotion velocity, hab. session 1	1.3	1.9	3.5	-1.6	-1.9	-1.2	-1.2	1.4	1.0	1.7	-1.4	1.2	1.2	-1.2	-1.2
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.8	0.8	-0.3	-0.3	-0.4	-0.5	0.3	-0.4	0.4	0.1	-0.6	-0.6
Time in novel zone, hab. session 2	0.8	0.8	1.9	-0.5	-0.3	0.4	0.4	-0.2	-0.2	-1.0	1.2	-1.2	-0.9	1.4	1.4
Total zone transitions, hab. session 2	1.4	1.8	3.4	-1.5	-1.4	-1.6	-1.6	1.3	1.0	1.8	-1.3	1.1	1.6	-0.7	-0.7
Total locomotion distance, hab. session 2	2.6	3.5	6.3	-2.4	-2.5	-1.7	-1.7	2.0	1.6	2.2	-1.8	1.7	1.6	-1.5	-1.5
Locomotion velocity, hab. session 2	2.2	3.0	6.2	-2.4	-2.5	-1.5	-1.5	2.0	1.6	1.9	-1.5	1.5	1.3	-1.3	-1.3
Novel to familiar place preference ratio	0.6	0.6	1.3	1.2	1.1	-0.9	-0.9	-0.9	-0.9	0.6	-0.4	0.4	0.4	-0.4	-0.4
Novelty place preference	0.4	0.4	1.1	1.0	1.1	-0.7	-0.7	-0.9	-0.8	0.5	-0.2	0.2	0.2	-0.1	-0.1
Time in novel zone, NPP test	0.4	0.4	1.0	0.9	1.0	-0.8	-0.8	-0.9	-0.9	0.5	-0.1	0.2	0.1	-0.1	-0.1
Total zone transitions, NPP test	1.3	1.8	5.5	-1.6	-1.7	-2.3	-2.3	0.9	0.2	1.6	-0.9	0.9	0.4	-0.3	-0.3
Total locomotion distance, NPP test	1.4	1.9	4.4	-2.1	-2.0	-2.0	-2.0	1.2	0.4	1.7	-1.0	0.9	0.4	-0.5	-0.5
Locomotion velocity, NPP test	1.9	2.8	5.6	-2.4	-2.3	-2.0	-2.0	1.6	0.9	2.1	-1.4	1.4	0.9	-0.9	-0.9
Intraocular pressure	1.8	2.5	9.6	-0.2	-0.2	-3.1	-3.1	0.1	-0.2	2.0	-1.2	1.1	1.1	-1.3	-1.3
Delta distance traveled before/after self-admin	0.3	0.4	1.0	-1.0	-0.9	-0.8	-0.8	0.7	0.4	0.3	-0.3	0.3	0.2	0.1	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	0.4	0.4	-0.2	-0.2	-0.4	-0.7	-0.3	0.4	-0.4	-0.4	0.7	0.7
Parametrial fat weight	1.2	2.3	3.7	1.2	1.2	1.9	1.9	-1.2	-1.0	-1.9	1.6	-1.4	-1.8	1.3	1.3
Pavlov. Cond. lever latency	1.8	2.3	4.8	1.2	0.7	0.8	0.8	-1.4	-1.2	-2.0	1.8	-1.8	-2.2	1.6	1.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.1	-0.2	0.1	0.1	0.2	-0.1	0.7	-0.6	0.8	0.8	-0.9	-0.9
Pavlov. Cond. change in total contacts	0.9	0.9	2.5	-0.2	-0.2	-0.7	-0.7	0.7	0.4	1.3	-1.2	1.2	1.6	-1.2	-1.2
Pavlov. Cond. index score	0.7	0.9	2.0	-0.3	-0.2	-0.1	-0.1	0.6	0.4	1.3	-1.2	1.2	1.4	-1.2	-1.2
Pavlov. Cond. latency score	1.0	1.3	3.2	-0.5	-0.3	-0.1	-0.1	0.9	0.7	1.5	-1.4	1.4	1.8	-1.4	-1.4
Pavlov. Cond. lever contacts	1.6	1.9	4.7	-1.0	-0.6	-0.6	-0.6	1.3	1.2	1.8	-1.7	1.6	2.2	-1.5	-1.5
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.2	-0.2	-0.6	-0.6	-0.0	0.1	-0.4	0.3	-0.5	-0.5	0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.9	2.3	7.7	0.8	1.1	-2.8	-2.8	-0.8	-1.0	1.7	-1.2	1.1	1.0	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.7	-0.3	-0.2	-0.3	-0.3	0.5	0.3	1.2	-1.0	1.0	1.3	-1.1	-1.1
Pavlov. Cond. response bias	0.2	0.3	0.8	-0.2	-0.0	-0.0	-0.0	0.3	0.1	0.8	-0.6	0.7	0.9	-0.7	-0.7
Pavlov. Cond. lever latency	1.6	2.1	5.9	-1.2	-1.0	2.4	2.4	1.6	2.1	0.0	-0.7	0.8	1.0	-0.9	-0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	-0.2	-0.0	0.1	0.1	-0.0	0.2	0.0	-0.2	0.2	-0.5	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.7	1.0	2.7	1.1	0.6	-1.6	-1.6	-1.1	-1.4	0.0	0.3	-0.4	-0.7	0.5	0.5
Pavlov. Cond. index score	0.7	0.9	2.1	1.0	0.9	-1.4	-1.4	-1.2	-1.3	0.0	0.3	-0.4	-0.8	0.5	0.5
Pavlov. Cond. latency score	0.7	0.9	2.4	0.9	0.8	-1.6	-1.6	-1.1	-1.3	0.1	0.2	-0.3	-0.8	0.4	0.4
Pavlov. Cond. lever contacts	0.9	1.3	4.4	0.7	0.5	-2.1	-2.1	-1.0	-1.6	0.1	0.4	-0.5	-0.7	0.7	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.2	0.4	0.4	-0.2	-0.4	-0.4	0.4	-0.4	0.2	0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.8	0.8	1.0	-0.2	-0.2	-1.0	-1.4	-0.3	0.6	-0.7	-0.6	1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.9	1.0	0.9	-1.4	-1.4	-1.2	-1.3	-0.0	0.3	-0.4	-0.8	0.5	0.5
Pavlov. Cond. response bias	0.7	0.9	2.0	0.9	0.8	-1.4	-1.4	-1.1	-1.4	-0.2	0.5	-0.6	-0.8	0.8	0.8
Time in closed arm before self-admin	2.0	2.3	4.6	-1.8	-1.3	-1.8	-1.8	1.4	0.8	2.1	-1.6	1.3	1.6	-0.9	-0.9
Time in closed arm after self-admin	0.2	0.2	0.5	-0.4	-0.5	-0.5	-0.5	0.4	0.2	0.7	-0.5	0.3	0.6	0.1	0.1
Time in open arm before self-admin	1.1	1.2	3.1	-0.2	-0.6	1.8	1.8	0.9	1.5	0.1	-0.9	0.9	0.8	-1.2	-1.2
Time in open arm after self-admin	0.4	0.4	1.4	-0.1	0.2	0.6	0.6	0.3	0.8	0.0	-0.4	0.5	0.3	-1.2	-1.2
Bone: periosteal estimation	2.0	4.2	15.4	3.9	3.1	-1.4	-1.4	-3.1	-3.3	0.0	0.2	-0.1	-0.2	0.1	0.1
Bone: periosteal perimeter	1.5	2.4	10.1	3.2	2.2	-1.0	-1.0	-2.5	-2.4	0.1	0.1	-0.0	-0.1	-0.0	-0.0
Bone: post-yield work	0.8	1.0	3.5	1.9	1.8	0.1	0.1	-1.6	-1.5	-0.4	0.4	-0.6	-0.1	0.4	0.4
Progressive ratio test 1 active lever presses	2.8	2.9	5.8	-2.1	-2.4	-2.2	-2.2	1.7	1.1	1.9	-1.4	1.3	1.2	-1.0	-1.0
Progressive ratio test 1 breakpoint	3.2	3.4	6.3	-2.1	-2.3	-2.5	-2.5	1.7	1.0	2.2	-1.6	1.4	1.4	-1.2	-1.2
Progressive ratio test 1 inactive lever presses	2.3	2.5	7.6	-1.2	-1.6	-2.7	-2.7	0.7	-0.1	2.2	-1.4	1.3	1.4	0.0	0.0
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	-0.2	-0.2	-0.7	-0.7	0.1	-0.0	0.2	-0.1	0.2	-0.2	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.1	0.2	-0.2	-0.2	-0.5	-0.5	0.1	-0.0	0.1	-0.0	0.1	-0.2	-0.0	-0.0
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.3	0.6	0.9	-0.8	-0.8	-0.9	-1.1	-0.0	0.4	-0.5	-0.5	1.1	1.1
Incentive Sensitization - Responses	0.4	0.4	1.0	0.9	1.0	0.5	0.5	-0.7	-0.5	-0.8	0.6	-0.4	-0.8	0.2	0.2
Incentive Sensitization - Breakpoint	0.5	0.5	1.2	1.0	1.1	0.7	0.7	-0.7	-0.5	-0.8	0.7	-0.5	-0.9	0.2	0.2
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.5	-0.4	-0.9	-0.3	-0.3	0.8	0.8	0.6	-0.9	1.0	0.8	-1.2	-1.2
Progressive ratio	0.5	0.6	2.5	0.7	0.6	1.6	1.6	-0.5	0.0	-0.9	0.4	-0.4	-0.3	0.2	0.2
Food seeking constrained by brief footshock	0.6	0.8	1.7	1.3	1.0	0.9	0.9	-0.9	-0.8	-0.8	0.8	-1.1	-0.0	0.7	0.7
Seeking ratio, punishment vs. effort	0.2	0.2	1.2	-0.1	0.0	-1.1	-1.1	0.1	-0.3	0.6	-0.1	-0.1	0.4	0.0	0.0
Retroperitoneal fat weight	3.1	10.3	18.7	-2.4	-2.3	-0.2	-0.2	3.6	3.5	3.2	-4.1	4.0	4.3	-3.7	-3.7
Reaction time number correct	0.5	0.7	1.5	0.5	0.6	-0.5	-0.5	-0.9	-0.8	-0.8	1.2	-1.1	-1.1	0.8	0.8
Reaction time mean minus median	0.6	0.8	3.8	0.1	0.0	2.0	2.0	0.6	0.9	-0.6	-0.0	0.0	0.4	-0.0	-0.0
Reaction time mean minus median AUC	0.6	0.8	1.5	0.7	0.7	0.9	0.9	-0.5	-0.5	-1.2	1.1	-1.1	-0.8	1.0	1.0
Reaction time num false alarms	1.2	1.6	5.2	0.5	0.7	-2.3	-2.3	-0.7	-1.0	1.7	-0.9	1.0	0.5	-0.9	-0.9
Reaction time num false alarms AUC	1.1	1.5	4.7	0.8	1.2	-2.2	-2.2	-1.1	-1.5	1.3	-0.6	0.6	0.3	-0.4	-0.4
Reaction time trials correct on left	0.5	0.7	1.5	0.5	0.6	-0.5	-0.5	-0.9	-0.8	-0.8	1.2	-1.1	-1.1	0.8	0.8
Reaction time trials on left	0.5	0.8	1.6	0.6	0.7	-0.4	-0.4	-1.0	-0.9	-0.9	1.3	-1.2	-1.2	0.8	0.8
Reaction time mean	1.0	1.4	4.7	0.5	0.5	2.2	2.2	-0.2	-0.1	-1.5	1.0	-1.0	-0.8	1.0	1.0
Reaction time mean AUC	0.8	1.1	4.0	0.3	0.3	2.0	2.0	-0.0	0.1	-1.3	0.9	-0.9	-0.6	0.9	0.9
Median of all reaction times	1.1	1.5	3.8	0.6	0.7	1.9	1.9	-0.5	-0.5	-1.6	1.2	-1.2	-1.0	1.2	1.2
Reaction time omissions	0.6	0.9	2.0	0.6	0.6	1.4	1.4	-0.6	-0.7	-1.2	0.9	-1.2	-0.4	0.8	0.8
Reaction time false alarm rate	0.8	1.1	2.4	0.3	0.6	-1.5	-1.5	-0.4	-0.6	1.6	-1.2	1.2	0.9	-0.9	-0.9
Reaction time premature initiation rate	1.1	1.4	3.1	0.2	-0.8	-0.9	-0.9	0.5	0.4	1.6	-1.7	1.8	1.0	-1.5	-1.5
Reaction time premature initiations	0.3	0.4	1.3	0.7	-0.3	-1.1	-1.1	-0.3	-0.4	0.8	-0.6	0.7	0.1	-0.6	-0.6
Std. dev. reaction times	1.0	1.4	5.3	0.6	0.5	2.3	2.3	-0.2	-0.0	-1.5	0.9	-1.0	-0.6	0.9	0.9
Reaction time trials completed	0.5	0.8	1.6	0.6	0.7	-0.4	-0.4	-1.0	-0.9	-0.9	1.3	-1.2	-1.2	0.8	0.8
Reaction time trials AUC	0.5	0.7	1.6	0.5	0.5	-0.2	-0.2	-0.9	-0.8	-0.9	1.3	-1.2	-1.2	0.8	0.8
Run reversals in cocaine runway, females	6.8	6.6	12.9	-2.0	-2.1	2.3	2.3	3.0	3.6	1.6	-2.7	2.7	2.8	-2.5	-2.5
Run reversals in cocaine runway, males	0.5	0.4	1.2	0.8	0.8	1.1	1.1	-0.5	-0.3	-0.5	0.1	-0.2	0.0	0.7	0.7
Latency to leave start box in cocaine runway	4.3	4.6	10.0	-3.2	-3.1	-0.8	-0.8	2.7	2.4	1.8	-1.8	1.8	1.5	-2.2	-2.2
Latency to leave start box in cocaine runway, F	5.7	6.2	9.8	-3.1	-3.0	-0.8	-0.8	2.7	2.8	2.3	-2.2	2.2	2.1	-3.1	-3.1
Latency to leave start box in cocaine runway, M	0.9	0.9	3.3	-1.7	-1.8	-0.0	-0.0	1.6	1.1	0.3	-0.4	0.4	0.4	0.1	0.1
Std. dev. time between licks in bursts	0.6	0.7	2.0	-1.3	-1.0	0.6	0.6	1.2	1.4	0.3	-0.5	0.5	0.5	-0.4	-0.4
Total sessions with >9 infusions	1.7	1.8	7.9	-1.0	-1.1	-2.8	-2.8	0.3	-0.1	1.5	-0.6	0.3	0.6	-0.7	-0.7
Short access day 1 total inactive lever presses	0.2	0.2	0.9	-0.5	-0.1	-0.9	-0.9	0.0	0.1	0.5	-0.1	-0.2	0.1	-0.5	-0.5
Short access day 10 total inactive lever presses	0.2	0.2	0.6	0.8	0.7	-0.1	-0.1	-0.6	-0.7	-0.1	0.1	0.0	-0.2	0.2	0.2
Short access day 1 total infusions	1.7	1.9	7.3	-1.5	-1.3	-2.7	-2.7	0.6	0.2	1.3	-0.5	0.3	0.5	-0.7	-0.7
Short access day 10 total infusions	2.1	2.3	6.5	-1.3	-1.3	-2.5	-2.5	0.8	0.2	2.2	-1.4	1.2	1.4	-0.7	-0.7
Short access total infusions	1.7	1.9	9.2	-0.9	-0.7	-3.0	-3.0	0.0	-0.5	1.5	-0.4	0.2	0.4	-0.2	-0.2
Short access day 1 locomotion	1.8	2.0	5.2	-1.4	-1.5	-2.3	-2.3	0.9	0.5	1.7	-1.1	0.8	1.2	-1.0	-1.0
Short access day 10 total locomotion	1.3	1.4	3.7	-0.3	-0.2	-1.5	-1.5	0.3	0.1	1.9	-1.6	1.3	1.6	-0.9	-0.9
Short access total locomotion	2.9	3.0	6.6	-1.5	-1.5	-2.3	-2.3	1.1	0.6	2.6	-2.0	1.8	2.0	-1.0	-1.0
One hour access (0.3 mA shock)	1.1	1.3	3.2	1.4	0.9	-1.4	-1.4	-1.4	-1.8	-0.4	0.9	-1.0	-1.1	0.7	0.7
Compulsive drug intake	1.2	1.2	4.2	2.1	1.8	0.1	0.1	-1.5	-1.5	-0.7	0.7	-0.5	-0.8	0.4	0.4
One hour access (shock baseline)	0.2	0.2	1.0	-0.1	0.1	-0.2	-0.2	-0.3	-0.5	-0.1	0.3	-0.5	-0.3	1.0	1.0
Social response proportion	0.8	0.8	2.1	1.5	1.4	1.1	1.1	-1.0	-0.9	-0.7	0.4	-0.4	-0.1	0.5	0.5
Social responses	0.5	0.7	1.7	0.1	0.1	-1.3	-1.3	0.0	-0.4	1.1	-0.8	0.9	0.6	-0.9	-0.9
Social time	0.8	1.1	4.0	1.7	2.0	1.0	1.0	-1.3	-1.0	-0.8	0.6	-0.6	0.1	0.4	0.4
Soleus weight	0.1	0.4	1.6	0.8	0.7	-0.3	-0.3	-0.0	0.2	0.5	-0.9	0.7	1.3	-0.5	-0.5
Bone: stiffness	0.2	0.4	1.4	1.2	1.1	0.5	0.5	-0.8	-0.8	-0.2	-0.1	0.0	-0.1	0.1	0.1
Tibialis anterior weight	0.9	2.9	6.5	-0.7	-0.9	0.1	0.1	2.0	2.2	1.4	-2.1	2.1	2.5	-1.9	-1.9
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.9	0.9	0.8	1.7	1.7	-0.6	-0.1	-1.1	0.6	-0.5	-0.9	0.5	0.5
Time to tail flick, vehicle, after self-admin	1.4	1.5	4.4	2.1	1.5	1.5	1.5	-1.5	-1.0	-1.2	0.7	-0.5	-1.0	0.1	0.1
Time to tail flick, test, before self-admin	1.3	1.3	6.1	1.7	2.5	1.7	1.7	-0.8	-0.4	-0.3	-0.3	0.2	0.3	0.1	0.1
Time to tail flick, test, after self-admin	1.1	1.1	3.0	1.6	1.7	-0.2	-0.2	-1.5	-1.5	-0.5	0.5	-0.5	-0.6	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.9	1.7	1.3	0.3	0.3	-1.5	-1.5	-1.1	1.2	-1.1	-1.1	0.6	0.6
Delta time to tail flick, test, before/after SA	1.6	1.4	3.1	1.2	0.8	-0.8	-0.8	-1.6	-1.7	-0.9	1.3	-1.3	-1.3	1.0	1.0
Tibia length	1.0	2.9	5.5	-0.7	-1.0	-0.1	-0.1	1.7	1.8	1.7	-2.2	2.3	2.1	-2.1	-2.1
Ambulatory time before self-admin	0.8	0.8	1.6	-0.5	-1.2	0.9	0.9	1.0	1.3	0.4	-0.9	1.0	0.8	-0.8	-0.8
Ambulatory time after self-admin	0.3	0.3	0.6	-0.1	-0.7	0.5	0.5	0.6	0.6	0.3	-0.7	0.7	0.5	-0.5	-0.5
Bone: tissue strength	0.3	0.3	0.5	-0.7	-0.7	-0.7	-0.7	0.1	0.1	-0.2	0.5	-0.4	-0.7	0.4	0.4
Total heroin consumption	0.1	0.1	0.3	0.5	0.3	0.4	0.4	-0.3	-0.4	-0.3	0.1	-0.1	-0.4	0.5	0.5
Bone: trabecular number	5.1	8.0	11.8	2.7	2.9	0.3	0.3	-3.1	-3.3	-2.7	3.2	-3.2	-2.8	3.4	3.4
Bone: trabecular spacing	2.8	3.6	5.7	-1.8	-2.4	0.3	0.3	2.3	2.4	1.4	-2.0	2.2	1.5	-2.3	-2.3
Bone: trabecular thickness	1.4	1.6	4.2	1.6	2.0	-0.7	-0.7	-1.9	-2.1	-0.3	0.8	-0.8	-0.5	1.2	1.2
Bone: trabecular tissue density	1.2	1.7	2.8	-1.5	-1.5	0.7	0.7	1.5	1.7	0.8	-1.4	1.5	0.7	-1.4	-1.4
Water consumed over 24 hours	1.9	2.2	4.9	-2.2	-2.2	-0.8	-0.8	2.0	1.7	1.2	-1.3	1.3	1.2	-1.2	-1.2
Number of responses in last shaping day	2.3	2.4	4.3	-2.1	-2.0	-1.1	-1.1	1.7	1.6	1.9	-1.8	1.5	1.7	-0.6	-0.6