Hub : Genes

Slc16a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Slc16a6 0.04 0.02 1.7e-05 0.04 0.04 0.04 0.04 5.0e-05 1.1e-05 3.0e-05 1.8e-05
2 Adipose gene expression Slc16a6 0.09 0.04 4.2e-10 0.07 0.08 0.07 0.08 1.3e-08 1.9e-09 3.5e-08 7.3e-09
3 NAcc gene expression Slc16a6 0.03 0.02 6.5e-06 0.02 0.03 0.02 0.02 8.6e-04 5.5e-05 3.3e-04 2.2e-04
4 OFC gene expression Slc16a6 0.24 0.13 1.9e-03 0.1 0.14 0.17 0.15 2.0e-03 2.6e-04 8.4e-05 1.9e-04
5 Brain alternative TSS XM_006247619.5 0.04 0.02 7.6e-04 0.03 0.04 0.03 0.02 5.2e-04 2.1e-04 4.1e-04 7.9e-03
6 pVTA gene expression Slc16a6 0.04 0.03 4.7e-03 0.03 0.02 0.02 0.02 9.9e-04 5.2e-03 1.1e-02 1.2e-02
7 Liver gene expression Slc16a6 0.21 0.1 5.6e-16 0.14 0.11 0.12 0.05 7.5e-15 2.5e-12 1.9e-13 5.1e-06
8 Brain gene expression Slc16a6 0.38 0.11 0.0e+00 0.45 0.44 0.44 0.45 5.0e-46 3.7e-44 8.6e-45 3.7e-46
9 RMTg alternative TSS NM_198760.2 0.13 0.07 3.6e-03 0.04 0.02 0.01 0.02 3.6e-02 8.8e-02 1.3e-01 9.7e-02
10 Brain alternative TSS XM_039086231.2 0.04 0.03 4.1e-04 0.05 0.04 0.04 0.01 2.1e-05 2.1e-04 3.0e-04 5.4e-02
11 PL isoform ratio NM_198760.2 0.03 0.02 3.8e-03 0.03 0.02 0.01 0.02 2.2e-04 5.5e-03 1.2e-02 6.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density5.49.211.2-3.0-3.2-3.2-3.4-2.9-3.03.0-3.1-3.02.53.1
Area under the delay curve0.10.10.3-0.1-0.0-0.00.20.40.4-0.50.30.40.0-0.6
BMI with tail6.020.828.83.53.94.03.95.15.4-5.15.24.9-5.2-3.3
BMI without tail10.231.040.84.04.84.55.66.36.4-6.26.26.4-6.1-4.0
Body weight7.432.548.62.83.94.04.56.76.9-6.76.67.0-6.8-4.9
Weight adjusted by age3.55.37.72.02.12.61.52.32.4-2.32.52.2-2.6-2.8
Bone surface5.910.716.9-4.1-4.1-4.1-3.7-2.6-2.92.8-3.0-2.62.52.9
Bone volume5.19.115.3-3.9-3.9-3.9-3.7-2.2-2.42.4-2.5-2.32.22.9
Breakpoint value in progressive ratio session1.61.94.31.91.91.82.10.80.7-1.00.61.1-0.5-1.5
Number of licking bursts0.10.20.8-0.10.10.10.20.40.4-0.40.30.4-0.4-0.9
Context. condit. distance diff. score0.10.20.70.10.20.20.40.30.2-0.20.40.5-0.4-0.8
Locomotion velocity, session 10.10.10.20.20.1-0.00.10.40.4-0.30.10.2-0.10.5
Locomotion distance, session 10.10.10.80.30.10.0-0.10.50.3-0.20.20.2-0.10.9
Locomotion velocity, session 20.40.42.5-0.1-0.5-0.7-0.4-0.3-0.40.3-0.5-0.70.71.6
Locomotion distance, session 20.30.43.10.3-0.2-0.3-0.4-0.1-0.30.3-0.2-0.80.31.8
Locomotion velocity, session 31.21.43.21.81.41.31.11.31.2-1.21.00.9-0.90.5
Locomotion distance, session 30.10.10.3-0.3-0.4-0.3-0.6-0.00.00.0-0.1-0.10.30.2
Stereotopy head waving bouts, day 30.70.92.11.30.90.70.5-1.0-0.80.7-0.9-0.81.40.7
Stereotopy head waving duration, day 30.40.51.40.80.50.40.1-0.7-0.80.7-0.9-0.61.20.7
Locomotion velocity, session 70.10.20.4-0.1-0.3-0.2-0.5-0.3-0.40.5-0.3-0.40.30.7
Locomotion distance, session 70.50.61.3-1.1-1.1-1.1-1.2-0.2-0.50.5-0.2-0.40.20.7
Stereotopy head waving bouts, day 70.50.51.10.50.30.2-0.2-1.0-0.90.8-1.0-1.00.70.9
Stereotopy head waving duration, day 70.91.02.10.70.30.3-0.2-1.4-1.31.2-1.4-1.31.10.9
Locomotion velocity, session 80.00.00.10.0-0.1-0.0-0.20.20.3-0.20.30.00.0-0.2
Locomotion distance, session 80.10.10.60.1-0.2-0.3-0.00.40.2-0.10.30.1-0.10.8
Degree of sensitization distance0.10.10.5-0.6-0.6-0.7-0.3-0.1-0.30.30.0-0.20.10.3
Degree of sensitization stereotypy0.10.10.40.70.50.40.2-0.3-0.20.2-0.3-0.3-0.20.5
Conditioned locomotion0.40.51.1-0.8-0.8-1.0-0.4-0.5-0.60.6-0.7-0.50.61.1
Cocaine response after cond. corrected0.30.41.3-1.1-1.0-0.9-1.0-0.4-0.40.2-0.3-0.2-0.2-0.2
Cocaine response after cond. not corrected0.40.51.6-1.3-1.0-0.9-1.0-0.4-0.40.3-0.3-0.30.0-0.0
Cocaine response before conditioning0.10.10.40.10.0-0.10.30.1-0.00.0-0.0-0.20.60.5
Saline control response5.37.09.62.42.62.43.13.02.8-2.82.83.1-2.3-1.7
Bone: connectivity density6.910.713.8-2.6-3.0-3.2-3.0-3.3-3.63.5-3.6-3.33.13.7
Bone: cortical apparent density1.01.44.52.11.91.71.70.30.6-0.70.50.40.1-0.3
Bone: cortical area0.30.41.0-0.3-0.3-0.60.21.00.8-0.80.60.7-0.31.0
Bone: cortical porosity1.11.23.5-1.9-1.6-1.8-1.0-0.3-0.40.5-0.4-0.70.11.3
Bone: cortical porosity0.50.51.6-1.3-1.0-1.1-0.30.60.5-0.40.50.3-0.70.4
Bone: cortical thickness4.16.814.13.83.43.13.22.42.4-2.42.32.1-1.7-0.2
Bone: cortical thickness0.80.93.21.81.41.11.60.40.4-0.40.20.20.10.7
Bone: cortical tissue density1.01.44.52.11.91.81.70.30.6-0.60.50.40.1-0.4
Condit. Reinf. active minus inactive responses0.50.61.2-0.7-0.4-0.50.31.11.1-1.10.90.9-0.6-0.2
Condit. Reinf. active-inactive response ratio0.10.10.4-0.7-0.3-0.40.4-0.00.0-0.1-0.20.20.1-0.5
Condit. Reinf. active responses0.40.51.0-1.0-0.8-1.0-0.20.90.8-0.80.70.5-0.40.6
Condit. Reinf. inactive responses0.50.62.4-0.7-1.0-1.0-1.10.30.1-0.00.2-0.3-0.11.5
Incentive salience index mean0.20.20.5-0.4-0.2-0.30.20.60.7-0.70.50.4-0.50.2
Condit. Reinf. lever presses0.10.20.40.60.60.60.50.30.5-0.40.40.1-0.60.1
Condit. Reinf. active minus inactive responses1.72.36.1-2.4-2.3-2.5-1.6-0.3-0.50.6-0.6-0.50.91.7
Condit. Reinf. active-inactive response ratio1.92.25.9-2.4-2.2-2.3-1.7-0.7-0.80.8-0.8-0.81.01.1
Condit. Reinf. active responses1.82.57.2-2.6-2.4-2.7-1.70.1-0.40.4-0.4-0.30.82.0
Condit. Reinf. inactive responses0.30.42.6-0.5-0.7-0.9-0.20.70.3-0.10.20.40.11.6
Condit. Reinf. lever presses0.30.51.4-1.1-0.9-1.2-0.00.70.4-0.30.40.5-0.10.8
Condit. Reinf. lever reinforcers received1.42.06.1-2.4-2.2-2.5-1.30.1-0.30.3-0.3-0.00.71.6
Conditioned reinforcement - actives0.81.42.0-1.2-1.4-1.4-1.3-0.8-1.01.0-1.1-1.11.11.2
Conditioned reinforcement - inactives0.10.20.8-0.5-0.5-0.4-0.90.20.4-0.20.10.3-0.0-0.5
Conditioned locomotion0.40.51.0-1.0-0.8-0.7-0.40.80.7-0.80.60.5-0.6-0.2
Patch foraging indifference point 0 sec1.83.37.50.30.50.11.02.72.3-2.42.42.7-1.80.7
Patch foraging indifference point AUC1.11.52.90.40.70.61.51.41.7-1.71.21.4-0.7-1.4
Delay disc. indifference point, 0s delay0.10.10.3-0.2-0.10.1-0.2-0.4-0.40.3-0.3-0.40.1-0.5
Delay disc. indifference point, 16s delay0.70.71.20.30.50.50.81.01.1-1.11.01.1-0.6-0.9
Delay disc. indifference point, 2s delay0.10.10.3-0.6-0.4-0.4-0.2-0.0-0.0-0.0-0.10.30.3-0.5
Delay disc. indifference point, 24s delay0.20.20.6-0.8-0.7-0.7-0.30.20.3-0.30.10.30.10.3
Delay disc. indifference point, 4s delay0.00.00.10.00.10.10.20.10.2-0.30.10.00.1-0.3
Delay disc. indifference point, 8s delay0.40.51.01.00.91.00.80.50.6-0.60.30.6-0.0-1.0
Indifference point function ln k1.22.08.1-0.5-1.0-1.2-1.5-0.8-1.51.6-1.2-1.21.12.8
Indifference point function log k1.22.08.1-0.5-1.0-1.2-1.5-0.8-1.51.6-1.2-1.21.12.8
Patch foraging total patch changes 0 sec1.83.47.60.40.60.31.22.72.3-2.42.42.8-1.80.7
Patch foraging total patch changes 12 sec1.11.43.2-0.4-0.1-0.31.11.61.6-1.81.31.8-0.9-0.3
Patch foraging total patch changes 18 sec3.04.68.01.41.51.42.02.82.6-2.82.42.8-1.7-0.9
Patch foraging total patch changes 24 sec0.71.23.4-0.3-0.2-0.50.61.71.5-1.61.21.8-0.50.2
Patch foraging total patch changes 6 sec3.75.712.70.20.70.51.93.33.1-3.22.83.6-2.2-1.4
Patch foraging time to switch 0 sec0.10.21.7-0.10.10.3-0.1-0.4-0.1-0.00.1-0.2-0.3-1.3
Patch foraging water rate 0 sec0.51.02.10.10.2-0.21.11.41.1-1.31.11.5-0.60.9
Patch foraging water rate 12 sec0.91.93.21.51.51.41.61.71.2-1.31.31.8-1.1-0.6
Patch foraging water rate 18 sec0.40.53.00.0-0.2-0.4-0.4-0.6-0.70.9-0.6-0.50.51.7
Patch foraging water rate 24 sec0.40.63.4-0.0-0.3-0.4-0.5-0.5-0.80.7-0.7-0.50.71.8
Patch foraging water rate 6 sec0.20.31.30.80.70.41.20.30.1-0.20.10.50.10.5
Seeking ratio, delayed vs. immediate footshock2.12.63.71.01.21.31.51.81.8-1.81.71.7-1.7-1.9
Distance traveled before self-admin0.50.71.61.11.01.20.80.50.5-0.70.50.3-0.5-1.3
Distance traveled after self-admin0.20.30.60.40.50.50.70.60.7-0.70.50.4-0.3-0.7
Extensor digitorum longus weight1.97.615.22.83.03.62.02.12.3-2.42.32.3-2.8-3.9
Bone: elastic displacement0.30.41.51.20.80.60.30.3-0.00.1-0.1-0.1-0.11.2
Bone: elastic work0.50.61.01.00.90.60.80.90.6-0.60.50.5-1.00.9
Bone: endosteal estimation4.29.333.5-5.8-4.9-4.8-3.5-1.2-1.21.2-1.4-0.91.20.7
Bone: endosteal perimeter4.710.034.2-5.8-5.2-5.1-3.7-1.0-1.31.2-1.5-1.01.21.3
Epididymis fat weight5.218.023.93.23.94.24.04.14.6-4.54.34.4-4.4-4.9
Delta time in closed arm before/after self-admin2.62.43.4-1.4-1.5-1.3-1.5-1.8-1.81.9-1.5-1.81.51.0
Delta time in open arm before/after self-admin0.20.20.40.50.10.1-0.5-0.4-0.60.6-0.6-0.60.60.4
Diff in mean of infusions in LGA sessions1.01.32.81.71.51.61.10.71.2-1.10.80.5-0.8-0.6
Delay discount exponential model param0.10.10.30.40.20.2-0.1-0.4-0.40.5-0.3-0.5-0.00.5
Extinction: sum of active levers before priming0.70.81.70.40.70.71.10.81.0-1.00.81.0-0.8-1.3
Active lever presses in extinction session 60.10.10.2-0.2-0.2-0.3-0.3-0.3-0.2-0.0-0.1-0.40.10.5
Bone: final force0.30.41.3-1.1-1.0-1.1-0.4-0.4-0.30.2-0.4-0.30.60.4
Bone: final moment0.30.51.4-1.2-1.0-1.2-0.5-0.4-0.40.3-0.5-0.30.70.5
Food consumed during 24 hour testing period4.56.310.02.72.82.63.22.32.5-2.32.42.4-2.3-1.9
Glucose0.20.30.60.50.30.7-0.50.50.2-0.20.20.3-0.8-0.8
Heart weight0.40.61.4-0.3-0.2-0.1-0.41.10.8-1.00.80.9-1.2-0.1
Delay discount hyperbolic model param0.10.10.30.40.20.2-0.0-0.3-0.30.5-0.3-0.40.00.6
Intermittent access intake day 1-15 change0.10.20.6-0.8-0.4-0.30.00.30.5-0.40.40.3-0.4-0.6
Intermittent access intake escalation0.10.30.6-0.5-0.1-0.10.30.60.8-0.70.80.5-0.7-0.4
Intermittent access intake escalation 20.20.31.4-1.2-0.7-0.70.1-0.00.2-0.20.10.2-0.1-0.5
Intermitt. access day 1 inactive lever presses0.10.50.90.00.30.30.50.90.9-1.00.90.9-0.8-0.6
Intermitt. access day 15 inactive lever presses0.40.91.80.50.70.90.50.71.3-1.21.20.7-1.2-0.9
Intermitt. access escalation Index0.10.10.50.40.50.30.70.10.3-0.40.20.0-0.30.3
Intermittent access day 1 total infusions0.20.31.50.30.0-0.1-0.10.80.4-0.50.50.1-0.31.2
Intermittent access day 15 total infusions0.50.71.7-0.20.0-0.10.41.21.3-1.31.20.6-1.10.4
Intermittent access terminal intake (last 3 days)0.30.40.9-1.0-0.7-0.7-0.00.60.7-0.70.60.2-0.50.2
Intermittent access total infusions0.20.30.8-0.4-0.4-0.6-0.10.70.5-0.70.40.2-0.30.9
Intermittent access day 1 locomotion0.81.02.30.10.10.1-0.01.41.4-1.31.50.6-1.40.6
Intermittent access day 15 total locomotion0.20.40.8-0.8-0.7-0.7-0.40.90.7-0.70.70.5-0.60.5
Intermittent access total locomotion1.31.64.1-0.2-0.1-0.20.32.01.7-1.71.71.4-1.50.4
Intermittent access standard deviation0.20.41.1-0.8-0.6-0.4-0.70.60.8-1.00.60.1-0.5-0.6
Left kidney weight0.41.93.11.01.11.11.31.61.6-1.51.41.7-1.8-0.9
Right kidney weight0.52.43.81.01.31.31.71.51.6-1.61.52.0-1.9-1.3
Cocaine induced anxiety1.82.54.0-1.6-1.8-1.5-2.0-1.7-1.51.5-1.6-1.81.50.3
Post-drug Anxiety1.51.62.9-1.0-1.2-1.0-1.6-1.5-1.21.3-1.3-1.71.30.4
Baseline Anxiety0.70.81.61.21.31.11.30.50.6-0.60.80.7-0.6-0.4
Tail length1.97.615.80.91.81.33.13.33.1-3.22.94.0-2.9-2.1
Length with tail1.66.914.60.31.21.22.03.13.1-3.12.93.8-2.9-3.1
Length without tail0.51.75.0-0.00.50.80.31.21.5-1.41.51.6-1.5-2.2
Times rat made contact with spout0.60.61.30.60.70.60.81.00.9-0.90.90.7-1.1-0.2
Lifetime Intake0.30.41.3-0.1-0.2-0.3-0.11.00.7-0.80.60.3-0.51.1
Liver weight, left0.30.62.2-1.4-1.2-1.5-0.40.2-0.0-0.10.00.1-0.00.6
Liver weight, right1.22.23.71.61.71.51.91.21.4-1.41.21.3-1.6-1.1
Locomotor activity0.60.92.20.50.50.30.81.51.3-1.11.20.9-1.00.6
Locomotor testing distance0.81.53.70.80.70.50.81.91.6-1.51.51.2-1.10.8
Locomotor testing rearing2.04.07.11.61.71.52.02.72.5-2.42.32.3-1.6-0.3
Locomotion in novel chamber0.30.41.60.80.81.00.50.00.4-0.20.50.1-0.5-1.3
Locomotion in novel chamber post-restriction0.10.10.6-0.0-0.0-0.20.0-0.3-0.20.4-0.2-0.3-0.00.7
Fecal boli incidents, locomotor time 10.91.43.0-1.7-1.7-1.5-1.7-1.0-0.80.8-0.7-0.90.60.3
Change in fecal boli incidents, locomotor task0.30.30.80.20.40.30.90.10.3-0.60.10.40.4-0.9
Time >=10cm from walls, locomotor time 10.20.20.50.3-0.00.0-0.6-0.4-0.50.6-0.5-0.70.70.5
Bouts of movement, locomotor time 10.60.71.10.60.70.70.80.81.0-0.91.00.7-1.0-0.9
Total resting periods, locomotor time 10.20.20.60.20.30.40.40.20.5-0.50.50.3-0.6-0.8
Rest time, locomotor task time 10.20.20.6-0.2-0.20.1-0.6-0.7-0.50.4-0.7-0.50.3-0.7
Distance moved, locomotor task time 11.52.23.51.91.91.71.91.41.3-1.31.41.3-1.1-0.9
Vertical activity count, locomotor time 10.71.63.01.51.51.31.71.21.2-1.21.31.2-0.7-0.8
Time >=10cm from walls, locomotor time 22.13.15.52.32.32.31.81.41.6-1.61.61.2-1.6-1.2
Bouts of movement, locomotor time 23.14.95.82.32.32.42.12.32.2-2.32.22.3-2.1-1.8
Total resting periods, locomotor time 22.23.84.42.02.02.11.72.11.9-2.01.92.0-1.8-1.8
Rest time, locomotor task time 22.02.54.2-0.9-1.1-0.8-1.8-2.1-1.91.9-2.0-1.72.0-0.2
Distance moved, locomotor task time 24.25.08.92.83.02.73.01.81.9-1.82.01.7-1.9-1.1
Vertical activity count, locomotor time 22.53.46.81.82.11.62.61.81.9-1.92.01.6-1.7-0.3
Light reinforcement 10.71.83.21.81.61.31.71.51.3-1.31.21.2-0.80.1
Light reinforcement 20.10.10.30.60.40.50.10.40.2-0.20.20.2-0.2-0.1
Bone: marrow area4.19.032.4-5.7-4.8-4.7-3.4-1.2-1.21.2-1.4-0.91.20.6
Bone: maximum diameter2.44.411.6-3.4-3.2-3.2-2.4-1.0-1.21.2-1.4-1.11.41.6
Bone: maximum force0.61.13.4-1.8-1.7-1.7-1.2-0.3-0.40.4-0.4-0.40.50.8
Bone: maximum moment0.71.23.5-1.9-1.7-1.8-1.1-0.3-0.40.4-0.5-0.40.60.8
Mean time between licks in bursts0.41.03.20.20.50.90.40.90.9-0.91.01.1-1.4-1.8
Mean num. licks in bursts0.10.10.60.50.30.20.20.20.1-0.10.30.1-0.20.8
Cd content in liver0.80.91.7-0.4-0.4-0.2-0.7-1.3-1.21.1-1.2-1.11.3-0.4
Co content in liver0.10.10.50.30.30.6-0.1-0.3-0.20.3-0.1-0.3-0.2-0.7
Cu content in liver0.20.20.6-0.7-0.7-0.6-0.8-0.5-0.10.3-0.2-0.50.20.2
Fe content in liver0.20.20.5-0.6-0.7-0.7-0.5-0.2-0.40.4-0.4-0.30.60.3
K content in liver1.21.22.6-0.9-0.9-1.1-0.8-1.1-1.01.0-1.1-1.01.01.6
Mg content in liver3.13.24.5-1.0-1.2-1.4-1.3-2.1-1.92.0-2.0-2.11.92.1
Mn content in liver3.43.88.7-0.9-1.3-1.5-1.6-2.0-2.02.0-2.1-2.22.13.0
Na content in liver0.40.40.9-0.3-0.4-0.3-0.6-0.8-0.70.6-0.9-0.51.00.5
Rb content in liver0.30.41.10.20.10.2-0.2-0.9-0.80.8-0.8-0.71.0-0.2
Se content in liver0.10.10.40.60.30.3-0.1-0.1-0.10.1-0.2-0.30.00.6
Sr content in liver0.70.61.20.30.40.50.30.91.0-1.01.10.8-1.1-0.6
Zn content in liver1.51.73.3-1.3-1.4-1.4-1.7-1.1-0.91.1-0.9-1.40.81.8
Bone: minimum diameter2.64.717.5-4.2-3.6-3.6-2.5-0.0-0.10.2-0.2-0.20.11.3
Time in familiar zone, hab. session 10.30.31.2-1.1-0.8-0.7-0.50.00.0-0.00.10.20.1-0.4
Time in novel zone, hab. session 10.20.20.60.80.60.30.50.0-0.00.0-0.0-0.2-0.10.7
Total zone transitions, hab. session 10.71.02.11.01.00.90.81.11.1-0.91.20.6-1.40.1
Total locomotion distance, hab. session 11.21.72.61.51.41.21.61.41.5-1.31.41.1-1.2-0.2
Locomotion velocity, hab. session 11.11.62.41.51.41.21.51.31.4-1.21.31.0-1.2-0.4
Time in familiar zone, hab. session 20.20.30.7-0.8-0.6-0.6-0.10.50.5-0.50.30.7-0.2-0.4
Time in novel zone, hab. session 20.90.92.10.30.0-0.1-0.4-1.3-1.21.2-1.1-1.40.91.2
Total zone transitions, hab. session 21.11.42.71.61.31.30.71.31.1-1.01.30.7-1.60.5
Total locomotion distance, hab. session 22.53.25.32.32.12.02.01.81.9-1.81.81.5-1.6-0.4
Locomotion velocity, hab. session 22.12.85.42.32.11.91.91.61.6-1.61.51.3-1.4-0.3
Novel to familiar place preference ratio0.50.51.9-1.4-1.1-1.1-0.60.50.5-0.50.20.4-0.40.1
Novelty place preference0.40.41.4-1.2-1.0-1.0-0.80.30.3-0.30.00.1-0.30.2
Time in novel zone, NPP test0.40.41.4-1.2-1.0-1.0-0.70.20.2-0.2-0.00.1-0.10.3
Total zone transitions, NPP test0.50.71.71.30.90.60.71.00.8-0.70.80.2-0.51.2
Total locomotion distance, NPP test0.81.12.61.61.30.91.50.91.1-1.01.00.4-0.40.9
Locomotion velocity, NPP test1.42.03.82.01.71.31.71.41.5-1.51.50.9-0.90.5
Intraocular pressure0.60.82.10.0-0.1-0.1-0.11.51.1-1.11.21.0-1.20.4
Delta distance traveled before/after self-admin0.10.20.70.10.1-0.10.30.40.6-0.30.30.2-0.30.8
Delta ambulatory time before/after self-admin0.30.41.2-1.1-0.9-1.1-0.4-0.30.00.3-0.3-0.30.30.9
Parametrial fat weight0.81.83.5-1.3-1.1-1.1-1.2-1.9-1.51.6-1.4-1.41.50.5
Pavlov. Cond. lever latency2.43.05.6-1.4-1.6-1.5-1.6-1.9-1.91.9-2.0-1.72.41.1
Pavlov. Cond. magazine entry latency0.40.51.3-0.00.30.11.10.60.6-0.90.70.8-0.7-0.7
Pavlov. Cond. change in total contacts1.01.12.40.30.60.51.11.21.1-1.21.21.1-1.5-0.8
Pavlov. Cond. index score0.91.11.90.30.70.61.21.11.2-1.31.31.1-1.4-1.0
Pavlov. Cond. latency score1.31.73.20.61.00.91.41.41.4-1.51.51.4-1.8-1.1
Pavlov. Cond. lever contacts1.82.14.41.11.31.31.31.51.6-1.71.71.4-2.1-1.0
Pavlov. Cond. magazine entry number0.20.30.70.3-0.1-0.0-0.7-0.4-0.40.7-0.6-0.60.50.8
Pavlov. Cond. intertrial magazine entries1.01.22.3-1.0-1.0-1.0-1.01.51.2-1.11.11.2-1.00.8
Pavlov. Cond. lever-magazine prob. diff.0.60.71.40.10.50.30.90.90.9-1.11.00.9-1.2-0.6
Pavlov. Cond. response bias0.20.20.5-0.00.30.10.70.40.5-0.70.60.4-0.7-0.4
Pavlov. Cond. lever latency1.01.43.21.51.51.81.10.40.6-0.80.70.6-1.1-1.8
Pavlov. Cond. magazine entry latency0.10.10.6-0.0-0.10.0-0.30.10.2-0.10.10.10.6-0.8
Pavlov. Cond. change in total contacts0.50.82.0-1.3-1.3-1.4-0.9-0.1-0.30.5-0.6-0.30.91.0
Pavlov. Cond. index score0.70.92.2-1.4-1.4-1.5-1.1-0.2-0.40.6-0.6-0.41.10.8
Pavlov. Cond. latency score0.60.81.9-1.2-1.3-1.4-1.1-0.1-0.30.4-0.5-0.31.10.8
Pavlov. Cond. lever contacts0.91.23.3-1.3-1.3-1.6-0.9-0.4-0.60.7-0.7-0.61.01.8
Pavlov. Cond. magazine entry number0.10.10.2-0.2-0.0-0.20.3-0.3-0.30.2-0.1-0.2-0.40.5
Pavlov. Cond. intertrial magazine entries0.20.41.0-1.0-0.8-1.0-0.2-0.4-0.30.3-0.1-0.40.20.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.0-1.3-1.4-1.4-1.1-0.2-0.40.5-0.5-0.41.00.7
Pavlov. Cond. response bias0.91.32.7-1.4-1.5-1.6-1.2-0.5-0.70.8-0.8-0.71.11.5
Time in closed arm before self-admin2.12.74.31.61.61.31.71.81.8-1.62.11.5-2.10.2
Time in closed arm after self-admin1.01.11.71.11.21.21.11.01.0-0.91.30.9-1.3-0.4
Time in open arm before self-admin0.90.94.40.60.71.10.60.80.9-0.80.70.8-0.7-2.1
Time in open arm after self-admin0.10.10.9-0.0-0.10.2-0.40.40.1-0.30.10.3-0.1-0.9
Bone: periosteal estimation2.45.018.0-4.2-3.7-3.8-2.3-0.3-0.50.4-0.7-0.40.81.2
Bone: periosteal perimeter1.83.010.8-3.3-2.9-2.8-2.2-0.1-0.40.2-0.5-0.20.40.8
Bone: post-yield work0.91.44.6-2.2-1.9-1.7-1.7-0.3-0.30.4-0.3-0.60.00.5
Progressive ratio test 1 active lever presses2.73.35.71.61.61.41.92.42.0-2.22.01.8-2.0-0.4
Progressive ratio test 1 breakpoint2.43.05.11.41.51.31.82.31.9-2.11.91.7-1.9-0.2
Progressive ratio test 1 inactive lever presses1.62.44.80.80.90.71.22.02.2-2.12.01.1-2.00.7
Progressive ratio test 2 active lever presses0.70.81.60.70.70.60.71.21.1-1.30.81.0-0.7-0.5
Progressive ratio test 2 breakpoint0.70.81.80.70.70.60.81.31.2-1.30.81.1-0.7-0.5
Progressive ratio test 2 inactive lever presses0.20.41.00.50.40.40.20.81.0-0.90.70.5-0.70.2
Incentive Sensitization - Responses0.20.21.30.00.00.10.00.50.5-0.70.10.70.0-1.1
Incentive Sensitization - Breakpoint0.20.21.5-0.0-0.00.1-0.00.40.4-0.60.00.70.1-1.2
Sum of active levers in priming session hrs 5-61.11.02.11.31.31.21.40.80.9-1.00.60.7-0.5-0.8
Progressive ratio0.10.21.3-0.5-0.4-0.2-0.6-0.2-0.10.0-0.10.20.1-1.1
Food seeking constrained by brief footshock0.50.61.2-1.0-0.9-0.8-0.6-0.8-0.91.1-0.6-0.80.1-0.0
Seeking ratio, punishment vs. effort0.10.10.60.10.1-0.10.40.2-0.00.10.2-0.2-0.30.7
Retroperitoneal fat weight2.510.813.22.53.13.23.43.03.4-3.43.33.4-3.6-3.6
Reaction time number correct0.61.11.7-0.5-0.8-0.7-1.1-1.0-1.31.2-1.3-0.91.31.1
Reaction time mean minus median0.10.31.60.30.70.70.7-0.30.1-0.10.00.0-0.5-1.3
Reaction time mean minus median AUC0.30.71.4-0.6-0.5-0.6-0.3-1.2-1.11.2-1.2-0.90.80.4
Reaction time num false alarms0.60.81.6-0.9-0.9-0.9-0.51.21.1-1.11.00.8-0.60.4
Reaction time num false alarms AUC0.50.81.8-1.3-1.2-1.3-0.80.80.7-0.70.70.3-0.30.8
Reaction time trials correct on left0.61.11.7-0.5-0.8-0.7-1.1-1.0-1.31.2-1.3-0.91.31.1
Reaction time trials on left0.61.21.9-0.6-0.9-0.8-1.1-1.1-1.41.3-1.3-0.91.31.1
Reaction time mean0.40.61.6-0.4-0.2-0.20.2-1.3-1.00.9-0.9-0.90.9-0.5
Reaction time mean AUC0.30.41.3-0.10.1-0.00.4-1.2-0.90.8-0.8-0.80.7-0.5
Median of all reaction times0.60.92.2-0.5-0.4-0.50.0-1.5-1.31.1-1.1-1.11.2-0.2
Reaction time omissions0.30.51.3-0.6-0.4-0.60.3-1.1-0.80.9-0.7-1.00.5-0.2
Reaction time false alarm rate0.60.81.7-0.7-0.6-0.6-0.11.21.3-1.31.30.8-0.9-0.0
Reaction time premature initiation rate1.01.42.80.00.20.30.81.71.7-1.61.51.4-1.0-1.2
Reaction time premature initiations0.10.20.5-0.6-0.5-0.5-0.10.70.5-0.50.30.50.0-0.2
Std. dev. reaction times0.30.61.9-0.4-0.1-0.20.1-1.4-0.90.9-0.9-1.10.6-0.5
Reaction time trials completed0.61.21.9-0.6-0.9-0.8-1.1-1.1-1.41.3-1.3-0.91.31.1
Reaction time trials AUC0.51.01.7-0.5-0.7-0.7-0.9-1.0-1.31.2-1.3-0.81.30.9
Run reversals in cocaine runway, females6.76.714.42.22.73.02.32.02.3-2.32.42.5-2.5-3.8
Run reversals in cocaine runway, males0.20.20.5-0.6-0.5-0.4-0.7-0.6-0.30.3-0.2-0.70.1-0.2
Latency to leave start box in cocaine runway3.94.49.02.82.72.53.01.81.5-1.61.82.0-1.2-1.4
Latency to leave start box in cocaine runway, F5.46.28.32.82.72.82.92.52.1-2.22.42.5-2.1-2.3
Latency to leave start box in cocaine runway, M0.70.62.31.31.30.91.50.10.1-0.20.20.10.30.6
Std. dev. time between licks in bursts0.50.71.91.41.31.40.90.40.4-0.50.40.4-0.4-0.9
Total sessions with >9 infusions1.72.13.91.61.41.31.12.01.6-1.61.61.3-1.4-0.1
Short access day 1 total inactive lever presses0.20.30.90.40.30.30.10.80.6-0.50.41.0-0.3-0.4
Short access day 10 total inactive lever presses0.00.10.3-0.3-0.3-0.3-0.6-0.5-0.00.0-0.2-0.50.20.2
Short access day 1 total infusions1.11.53.41.51.21.10.81.91.3-1.31.21.3-1.10.3
Short access day 10 total infusions1.62.04.30.70.70.50.92.11.8-1.91.81.2-1.81.0
Short access total infusions0.50.61.70.50.30.10.11.30.9-0.90.90.5-0.81.3
Short access day 1 locomotion4.15.18.92.02.01.92.13.02.5-2.42.52.5-2.4-0.9
Short access day 10 total locomotion0.71.33.20.10.20.20.21.51.6-1.31.81.0-1.70.3
Short access total locomotion3.03.66.61.41.51.41.42.62.3-2.12.41.8-2.3-0.3
One hour access (0.3 mA shock)0.40.41.3-1.1-1.0-1.1-0.50.1-0.10.1-0.4-0.00.50.6
Compulsive drug intake0.91.13.3-1.8-1.6-1.7-0.8-0.8-0.60.4-0.8-0.20.80.7
One hour access (shock baseline)0.00.00.10.1-0.0-0.0-0.10.30.2-0.30.2-0.2-0.10.2
Social response proportion0.50.61.6-1.3-1.0-1.0-0.7-0.7-0.40.4-0.4-1.0-0.0-0.2
Social responses0.20.30.7-0.3-0.2-0.40.50.70.9-0.80.70.2-0.70.1
Social time0.81.02.5-1.5-1.3-1.1-1.6-1.0-0.80.7-0.6-1.0-0.10.4
Soleus weight0.10.41.7-0.5-0.3-0.0-0.60.60.6-0.40.50.3-1.3-0.5
Bone: stiffness0.30.62.0-1.4-1.1-1.1-0.7-0.5-0.40.3-0.3-0.40.5-0.1
Tibialis anterior weight1.24.07.51.51.92.11.81.81.9-2.02.01.9-2.7-2.2
Time to tail flick, vehicle, before self-admin0.60.60.9-0.8-0.7-0.5-1.0-1.0-0.80.7-0.7-0.70.9-0.6
Time to tail flick, vehicle, after self-admin0.50.61.3-1.0-1.0-0.7-1.1-0.7-0.50.5-0.9-0.60.7-0.6
Time to tail flick, test, before self-admin0.50.62.5-1.6-1.2-1.1-0.9-0.10.2-0.10.20.1-0.2-0.2
Time to tail flick, test, after self-admin0.40.41.4-1.2-1.0-1.1-0.8-0.3-0.20.0-0.1-0.20.00.5
Delta time to tail flick, vehicle, before/after SA0.60.61.1-1.0-1.0-1.0-0.7-0.7-0.70.7-0.8-0.60.60.4
Delta time to tail flick, test, before/after SA0.70.81.2-0.7-0.9-0.9-1.0-0.8-1.10.9-0.8-0.90.80.7
Tibia length1.33.55.11.11.51.61.52.02.2-2.32.02.1-1.9-2.1
Ambulatory time before self-admin1.01.53.01.71.61.71.50.70.7-0.90.70.6-0.6-1.6
Ambulatory time after self-admin0.50.51.50.60.80.71.20.60.7-0.70.50.6-0.4-1.0
Bone: tissue strength0.20.20.50.60.20.2-0.2-0.1-0.30.3-0.3-0.40.50.7
Total heroin consumption0.10.10.20.10.1-0.10.3-0.3-0.00.0-0.4-0.20.50.1
Bone: trabecular number5.99.811.9-2.7-3.0-3.1-3.1-3.1-3.33.3-3.3-3.22.83.4
Bone: trabecular spacing3.64.86.32.02.22.32.52.02.3-2.32.12.2-1.6-2.5
Bone: trabecular thickness2.32.95.2-2.2-2.2-2.3-2.1-1.1-1.21.2-1.2-1.41.02.1
Bone: trabecular tissue density1.11.62.61.31.41.51.30.91.2-1.31.21.2-0.6-1.6
Water consumed over 24 hours1.62.14.62.22.01.82.01.11.1-1.11.11.0-1.0-0.6
Number of responses in last shaping day1.41.62.61.41.41.40.71.31.6-1.41.50.7-1.4-0.1