Hub : Genes

Slc16a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Slc16a6 0.04 0.02 1.7e-05 0.04 0.04 0.04 0.04 5.0e-05 1.1e-05 3.0e-05 1.7e-05
2 Adipose gene expression Slc16a6 0.09 0.04 4.2e-10 0.07 0.08 0.07 0.08 1.3e-08 1.9e-09 3.5e-08 7.2e-09
3 NAcc gene expression Slc16a6 0.03 0.02 6.5e-06 0.02 0.03 0.02 0.02 8.6e-04 5.5e-05 3.3e-04 2.3e-04
4 OFC gene expression Slc16a6 0.24 0.13 1.9e-03 0.1 0.14 0.17 0.15 2.0e-03 2.6e-04 8.4e-05 1.9e-04
5 Brain alternative TSS XM_006247619.5 0.04 0.02 7.6e-04 0.03 0.04 0.03 0.02 5.2e-04 2.1e-04 4.3e-04 7.7e-03
6 pVTA gene expression Slc16a6 0.04 0.03 4.7e-03 0.03 0.02 0.02 0.02 9.9e-04 5.2e-03 1.1e-02 1.1e-02
7 Liver gene expression Slc16a6 0.21 0.1 5.6e-16 0.14 0.11 0.12 0.05 7.5e-15 2.5e-12 1.9e-13 5.3e-06
8 LHb gene expression Slc16a6 0.29 0.13 8.9e-05 0.14 0.12 0.1 0.07 3.8e-04 1.0e-03 2.1e-03 1.2e-02
9 Brain gene expression Slc16a6 0.38 0.11 0.0e+00 0.45 0.44 0.44 0.45 5.0e-46 3.7e-44 8.4e-45 3.7e-46
10 RMTg alternative TSS NM_198760.2 0.13 0.07 3.6e-03 0.04 0.02 0.01 0.02 3.6e-02 8.8e-02 1.3e-01 1.0e-01
11 Brain alternative TSS XM_039086231.2 0.04 0.03 4.1e-04 0.05 0.04 0.04 0.01 2.1e-05 2.1e-04 3.0e-04 5.2e-02
12 PL isoform ratio NM_198760.2 0.03 0.02 3.8e-03 0.03 0.02 0.01 0.02 2.2e-04 5.5e-03 1.2e-02 5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density5.09.311.2-3.0-3.2-3.23.4-2.93.0-3.03.2-3.13.0-2.5-3.1
Area under the delay curve0.10.10.3-0.1-0.0-0.0-0.20.4-0.40.5-0.10.3-0.4-0.00.6
BMI with tail6.121.328.83.53.94.0-3.95.1-5.45.1-5.15.2-4.95.23.3
BMI without tail5.931.640.84.04.84.5-5.66.3-6.46.2-6.26.2-6.46.14.0
Body weight7.633.148.62.83.94.0-4.56.7-6.96.7-6.36.6-7.06.84.9
Weight adjusted by age1.85.47.72.02.12.6-1.52.3-2.42.3-2.52.5-2.22.62.8
Bone surface5.410.616.9-4.1-4.1-4.13.7-2.62.9-2.83.1-3.02.6-2.5-2.9
Bone volume4.58.915.3-3.9-3.9-3.93.7-2.22.4-2.42.7-2.52.3-2.2-2.9
Breakpoint value in progressive ratio session1.01.84.31.91.91.8-2.10.8-0.71.0-0.50.6-1.10.51.5
Number of licking bursts0.10.20.8-0.10.10.1-0.20.4-0.40.4-0.20.3-0.40.40.9
Context. condit. distance diff. score0.10.20.70.10.20.2-0.40.3-0.20.2-0.50.4-0.50.40.8
Locomotion velocity, session 10.10.10.20.20.1-0.0-0.10.4-0.40.3-0.10.1-0.20.1-0.5
Locomotion distance, session 10.10.10.80.30.10.00.10.5-0.30.2-0.10.2-0.20.1-0.9
Locomotion velocity, session 20.40.42.5-0.1-0.5-0.70.4-0.30.4-0.30.5-0.50.7-0.7-1.6
Locomotion distance, session 20.30.43.10.3-0.2-0.30.4-0.10.3-0.30.2-0.20.8-0.3-1.8
Locomotion velocity, session 31.21.33.21.81.41.3-1.11.3-1.21.2-1.01.0-0.90.9-0.5
Locomotion distance, session 30.10.10.3-0.3-0.4-0.30.6-0.0-0.0-0.00.3-0.10.1-0.3-0.2
Stereotopy head waving bouts, day 30.70.92.11.30.90.7-0.5-1.00.8-0.70.9-0.90.8-1.4-0.7
Stereotopy head waving duration, day 30.40.51.40.80.50.4-0.1-0.70.8-0.70.8-0.90.6-1.2-0.7
Locomotion velocity, session 70.10.20.4-0.1-0.3-0.20.5-0.30.4-0.50.4-0.30.4-0.3-0.7
Locomotion distance, session 70.40.51.3-1.1-1.1-1.11.2-0.20.5-0.50.3-0.20.4-0.2-0.7
Stereotopy head waving bouts, day 70.50.61.20.50.30.20.2-1.00.9-0.81.1-1.01.0-0.7-0.9
Stereotopy head waving duration, day 70.91.12.30.70.30.30.2-1.41.3-1.21.5-1.41.3-1.1-0.9
Locomotion velocity, session 80.00.00.20.0-0.1-0.00.20.2-0.30.2-0.50.3-0.0-0.00.2
Locomotion distance, session 80.10.10.60.1-0.2-0.30.00.4-0.20.1-0.40.3-0.10.1-0.8
Degree of sensitization distance0.10.10.5-0.6-0.6-0.70.3-0.10.3-0.3-0.00.00.2-0.1-0.3
Degree of sensitization stereotypy0.10.10.40.70.50.4-0.2-0.30.2-0.20.4-0.30.30.2-0.5
Conditioned locomotion0.40.51.1-0.8-0.8-1.00.4-0.50.6-0.60.8-0.70.5-0.6-1.1
Cocaine response after cond. corrected0.30.41.3-1.1-1.0-0.91.0-0.40.4-0.20.4-0.30.20.20.2
Cocaine response after cond. not corrected0.30.41.6-1.3-1.0-0.91.0-0.40.4-0.30.4-0.30.3-0.00.0
Cocaine response before conditioning0.10.10.40.10.0-0.1-0.30.10.0-0.0-0.0-0.00.2-0.6-0.5
Saline control response5.17.19.62.42.62.4-3.13.0-2.82.8-2.82.8-3.12.31.7
Bone: connectivity density6.910.913.8-2.6-3.0-3.23.0-3.33.6-3.53.7-3.63.3-3.1-3.7
Bone: cortical apparent density0.81.34.52.11.91.7-1.70.3-0.60.7-0.50.5-0.4-0.10.3
Bone: cortical area0.30.41.0-0.3-0.3-0.6-0.21.0-0.80.8-0.40.6-0.70.3-1.0
Bone: cortical porosity1.01.13.5-1.9-1.6-1.81.0-0.30.4-0.50.4-0.40.7-0.1-1.3
Bone: cortical porosity0.40.51.6-1.3-1.0-1.10.30.6-0.50.4-0.50.5-0.30.7-0.4
Bone: cortical thickness4.06.614.13.83.43.1-3.22.4-2.42.4-2.02.3-2.11.70.2
Bone: cortical thickness0.70.83.21.81.41.1-1.60.4-0.40.4-0.10.2-0.2-0.1-0.7
Bone: cortical tissue density0.81.34.52.11.91.8-1.70.3-0.60.6-0.50.5-0.4-0.10.4
Condit. Reinf. active minus inactive responses0.60.61.2-0.7-0.4-0.5-0.31.1-1.11.1-0.90.9-0.90.60.2
Condit. Reinf. active-inactive response ratio0.10.10.4-0.7-0.3-0.4-0.4-0.0-0.00.10.1-0.2-0.2-0.10.5
Condit. Reinf. active responses0.40.51.0-1.0-0.8-1.00.20.9-0.80.8-0.70.7-0.50.4-0.6
Condit. Reinf. inactive responses0.40.52.4-0.7-1.0-1.01.10.3-0.10.0-0.10.20.30.1-1.5
Incentive salience index mean0.20.20.5-0.4-0.2-0.3-0.20.6-0.70.7-0.60.5-0.40.5-0.2
Condit. Reinf. lever presses0.10.20.40.60.60.6-0.50.3-0.50.4-0.50.4-0.10.6-0.1
Condit. Reinf. active minus inactive responses1.42.16.1-2.4-2.3-2.51.6-0.30.5-0.60.8-0.60.5-0.9-1.7
Condit. Reinf. active-inactive response ratio1.32.15.9-2.4-2.2-2.31.7-0.70.8-0.81.0-0.80.8-1.0-1.1
Condit. Reinf. active responses1.62.37.2-2.6-2.4-2.71.70.10.4-0.40.5-0.40.3-0.8-2.0
Condit. Reinf. inactive responses0.30.42.6-0.5-0.7-0.90.20.7-0.30.1-0.30.2-0.4-0.1-1.6
Condit. Reinf. lever presses0.30.41.4-1.1-0.9-1.20.00.7-0.40.3-0.40.4-0.50.1-0.8
Condit. Reinf. lever reinforcers received1.31.96.1-2.4-2.2-2.51.30.10.3-0.30.5-0.30.0-0.7-1.6
Conditioned reinforcement - actives0.31.42.0-1.2-1.4-1.41.3-0.81.0-1.01.1-1.11.1-1.1-1.2
Conditioned reinforcement - inactives0.10.20.8-0.5-0.5-0.40.90.2-0.40.2-0.20.1-0.30.00.5
Conditioned locomotion0.30.51.0-1.0-0.8-0.70.40.8-0.70.8-0.60.6-0.50.60.2
Patch foraging indifference point 0 sec1.23.57.50.30.50.1-1.02.7-2.32.4-2.42.4-2.71.8-0.7
Patch foraging indifference point AUC0.61.52.90.40.70.6-1.51.4-1.71.7-1.21.2-1.40.71.4
Delay disc. indifference point, 0s delay0.10.10.3-0.2-0.10.10.2-0.40.4-0.30.3-0.30.4-0.10.5
Delay disc. indifference point, 16s delay0.50.71.20.30.50.5-0.81.0-1.11.1-0.91.0-1.10.60.9
Delay disc. indifference point, 2s delay0.10.10.3-0.6-0.4-0.40.2-0.00.00.00.3-0.1-0.3-0.30.5
Delay disc. indifference point, 24s delay0.10.20.6-0.8-0.7-0.70.30.2-0.30.3-0.00.1-0.3-0.1-0.3
Delay disc. indifference point, 4s delay0.00.00.10.00.10.1-0.20.1-0.20.30.10.1-0.0-0.10.3
Delay disc. indifference point, 8s delay0.30.51.01.00.91.0-0.80.5-0.60.6-0.20.3-0.60.01.0
Indifference point function ln k0.72.08.1-0.5-1.0-1.21.5-0.81.5-1.61.3-1.21.2-1.1-2.8
Indifference point function log k0.72.08.1-0.5-1.0-1.21.5-0.81.5-1.61.3-1.21.2-1.1-2.8
Patch foraging total patch changes 0 sec1.23.67.60.40.60.3-1.22.7-2.32.4-2.42.4-2.81.8-0.7
Patch foraging total patch changes 12 sec1.11.53.2-0.4-0.1-0.3-1.11.6-1.61.8-1.31.3-1.80.90.3
Patch foraging total patch changes 18 sec2.04.78.01.41.51.4-2.02.8-2.62.8-2.52.4-2.81.70.9
Patch foraging total patch changes 24 sec0.41.23.4-0.3-0.2-0.5-0.61.7-1.51.6-1.21.2-1.80.5-0.2
Patch foraging total patch changes 6 sec3.45.812.70.20.70.5-1.93.3-3.13.2-2.72.8-3.62.21.4
Patch foraging time to switch 0 sec0.00.21.7-0.10.10.30.1-0.40.10.0-0.10.10.20.31.3
Patch foraging water rate 0 sec0.31.02.10.10.2-0.2-1.11.4-1.11.3-1.01.1-1.50.6-0.9
Patch foraging water rate 12 sec0.51.93.21.51.51.4-1.61.7-1.21.3-1.21.3-1.81.10.6
Patch foraging water rate 18 sec0.20.53.00.0-0.2-0.40.4-0.60.7-0.90.7-0.60.5-0.5-1.7
Patch foraging water rate 24 sec0.40.63.4-0.0-0.3-0.40.5-0.50.8-0.70.8-0.70.5-0.7-1.8
Patch foraging water rate 6 sec0.20.31.30.80.70.4-1.20.3-0.10.20.10.1-0.5-0.1-0.5
Seeking ratio, delayed vs. immediate footshock1.92.73.71.01.21.3-1.51.8-1.81.8-1.81.7-1.71.71.9
Distance traveled before self-admin0.30.61.61.11.01.2-0.80.5-0.50.7-0.50.5-0.30.51.3
Distance traveled after self-admin0.20.30.60.40.50.5-0.70.6-0.70.7-0.40.5-0.40.30.7
Extensor digitorum longus weight1.87.315.22.83.03.6-2.02.1-2.32.4-2.12.3-2.32.83.9
Bone: elastic displacement0.30.31.51.20.80.6-0.30.30.0-0.10.2-0.10.10.1-1.2
Bone: elastic work0.40.61.01.00.90.6-0.80.9-0.60.6-0.30.5-0.51.0-0.9
Bone: endosteal estimation3.68.733.5-5.8-4.9-4.83.5-1.21.2-1.21.6-1.40.9-1.2-0.7
Bone: endosteal perimeter3.89.434.2-5.8-5.2-5.13.7-1.01.3-1.21.5-1.51.0-1.2-1.3
Epididymis fat weight3.617.923.93.23.94.2-4.04.1-4.64.5-4.24.3-4.44.44.9
Delta time in closed arm before/after self-admin2.62.43.4-1.4-1.5-1.31.5-1.81.8-1.91.4-1.51.8-1.5-1.0
Delta time in open arm before/after self-admin0.20.20.40.50.10.10.5-0.40.6-0.60.6-0.60.6-0.6-0.4
Diff in mean of infusions in LGA sessions0.71.22.81.71.51.6-1.10.7-1.21.1-0.90.8-0.50.80.6
Delay discount exponential model param0.10.10.30.40.20.20.1-0.40.4-0.50.2-0.30.50.0-0.5
Extinction: sum of active levers before priming0.50.81.70.40.70.7-1.10.8-1.01.0-0.70.8-1.00.81.3
Active lever presses in extinction session 60.10.10.2-0.2-0.2-0.30.3-0.30.20.00.1-0.10.4-0.1-0.5
Bone: final force0.30.41.3-1.1-1.0-1.10.4-0.40.3-0.20.8-0.40.3-0.6-0.4
Bone: final moment0.30.51.4-1.2-1.0-1.20.5-0.40.4-0.30.9-0.50.3-0.7-0.5
Food consumed during 24 hour testing period3.16.210.02.72.82.6-3.22.3-2.52.3-2.42.4-2.42.31.9
Glucose0.10.20.60.50.30.70.50.5-0.20.2-0.10.2-0.30.80.8
Heart weight0.40.61.4-0.3-0.2-0.10.41.1-0.81.0-0.80.8-0.91.20.1
Delay discount hyperbolic model param0.10.10.30.40.20.20.0-0.30.3-0.50.1-0.30.4-0.0-0.6
Intermittent access intake day 1-15 change0.00.20.6-0.8-0.4-0.3-0.00.3-0.50.4-0.50.4-0.30.40.6
Intermittent access intake escalation0.10.30.7-0.5-0.1-0.1-0.30.6-0.80.7-0.80.8-0.50.70.4
Intermittent access intake escalation 20.10.21.4-1.2-0.7-0.7-0.1-0.0-0.20.2-0.10.1-0.20.10.5
Intermitt. access day 1 inactive lever presses0.00.50.90.00.30.3-0.50.9-0.91.0-1.00.9-0.90.80.6
Intermitt. access day 15 inactive lever presses0.20.91.80.50.70.9-0.50.7-1.31.2-1.31.2-0.71.20.9
Intermitt. access escalation Index0.00.10.50.40.50.3-0.70.1-0.30.4-0.20.2-0.00.3-0.3
Intermittent access day 1 total infusions0.10.31.50.30.0-0.10.10.8-0.40.5-0.50.5-0.10.3-1.2
Intermittent access day 15 total infusions0.30.81.7-0.20.0-0.1-0.41.2-1.31.3-1.31.2-0.61.1-0.4
Intermittent access terminal intake (last 3 days)0.20.40.9-1.0-0.7-0.70.00.6-0.70.7-0.60.6-0.20.5-0.2
Intermittent access total infusions0.20.30.8-0.4-0.4-0.60.10.7-0.50.7-0.40.4-0.20.3-0.9
Intermittent access day 1 locomotion0.61.12.40.10.10.10.01.4-1.41.3-1.61.5-0.61.4-0.6
Intermittent access day 15 total locomotion0.10.40.8-0.8-0.7-0.70.40.9-0.70.7-0.70.7-0.50.6-0.5
Intermittent access total locomotion1.41.74.1-0.2-0.1-0.2-0.32.0-1.71.7-1.81.7-1.41.5-0.4
Intermittent access standard deviation0.10.41.1-0.8-0.6-0.40.70.6-0.81.0-0.70.6-0.10.50.6
Left kidney weight0.21.93.11.01.11.1-1.31.6-1.61.5-1.41.4-1.71.80.9
Right kidney weight0.32.33.81.01.31.3-1.71.5-1.61.6-1.31.5-2.01.91.3
Cocaine induced anxiety0.92.64.0-1.6-1.8-1.52.0-1.71.5-1.51.6-1.61.8-1.5-0.3
Post-drug Anxiety1.41.62.9-1.0-1.2-1.01.6-1.51.2-1.31.3-1.31.7-1.3-0.4
Baseline Anxiety0.50.81.61.21.31.1-1.30.5-0.60.6-0.80.8-0.70.60.4
Tail length1.47.615.80.91.81.3-3.13.3-3.13.2-2.82.9-4.02.92.1
Length with tail1.67.014.60.31.21.2-2.03.1-3.13.1-2.72.9-3.82.93.1
Length without tail0.31.75.0-0.00.50.8-0.31.2-1.51.4-1.21.5-1.61.52.2
Times rat made contact with spout0.60.71.30.60.70.6-0.81.0-0.90.9-0.90.9-0.71.10.2
Lifetime Intake0.30.41.3-0.1-0.2-0.30.11.0-0.70.8-0.70.6-0.30.5-1.1
Liver weight, left0.30.52.2-1.4-1.2-1.50.40.20.00.1-0.00.0-0.10.0-0.6
Liver weight, right1.22.13.71.61.71.5-1.91.2-1.41.4-1.31.2-1.31.61.1
Locomotor activity0.60.92.20.50.50.3-0.81.5-1.31.1-1.21.2-0.91.0-0.6
Locomotor testing distance0.61.53.70.80.70.5-0.81.9-1.61.5-1.51.5-1.21.1-0.8
Locomotor testing rearing1.14.07.11.61.71.5-2.02.7-2.52.4-2.22.3-2.31.60.3
Locomotion in novel chamber0.30.41.60.80.81.0-0.50.0-0.40.2-0.40.5-0.10.51.3
Locomotion in novel chamber post-restriction0.00.10.6-0.0-0.0-0.2-0.0-0.30.2-0.40.0-0.20.30.0-0.7
Fecal boli incidents, locomotor time 10.51.33.0-1.7-1.7-1.51.7-1.00.8-0.80.8-0.70.9-0.6-0.3
Change in fecal boli incidents, locomotor task0.20.20.80.20.40.3-0.90.1-0.30.60.00.1-0.4-0.40.9
Time >=10cm from walls, locomotor time 10.20.20.50.3-0.00.00.6-0.40.5-0.60.3-0.50.7-0.7-0.5
Bouts of movement, locomotor time 10.60.81.30.60.70.7-0.80.8-1.00.9-1.11.0-0.71.00.9
Total resting periods, locomotor time 10.20.20.60.20.30.4-0.40.2-0.50.5-0.70.5-0.30.60.8
Rest time, locomotor task time 10.20.30.6-0.2-0.20.10.6-0.70.5-0.40.6-0.70.5-0.30.7
Distance moved, locomotor task time 10.82.23.51.91.91.7-1.91.4-1.31.3-1.21.4-1.31.10.9
Vertical activity count, locomotor time 10.21.63.01.51.51.3-1.71.2-1.21.2-1.11.3-1.20.70.8
Time >=10cm from walls, locomotor time 21.13.15.52.32.32.3-1.81.4-1.61.6-1.71.6-1.21.61.2
Bouts of movement, locomotor time 21.54.95.82.32.32.4-2.12.3-2.22.3-2.32.2-2.32.11.8
Total resting periods, locomotor time 20.93.84.42.02.02.1-1.72.1-1.92.0-2.01.9-2.01.81.8
Rest time, locomotor task time 21.62.74.2-0.9-1.1-0.81.8-2.11.9-1.92.0-2.01.7-2.00.2
Distance moved, locomotor task time 23.74.98.92.83.02.7-3.01.8-1.91.8-2.02.0-1.71.91.1
Vertical activity count, locomotor time 21.53.46.81.82.11.6-2.61.8-1.91.9-2.02.0-1.61.70.3
Light reinforcement 10.41.73.21.81.61.3-1.71.5-1.31.3-1.11.2-1.20.8-0.1
Light reinforcement 20.00.10.30.60.40.5-0.10.4-0.20.2-0.30.2-0.20.20.1
Bone: marrow area3.48.432.4-5.7-4.8-4.73.4-1.21.2-1.21.6-1.40.9-1.2-0.6
Bone: maximum diameter2.14.311.6-3.4-3.2-3.22.4-1.01.2-1.21.6-1.41.1-1.4-1.6
Bone: maximum force0.51.13.4-1.8-1.7-1.71.2-0.30.4-0.40.8-0.40.4-0.5-0.8
Bone: maximum moment0.61.13.5-1.9-1.7-1.81.1-0.30.4-0.40.8-0.50.4-0.6-0.8
Mean time between licks in bursts0.21.03.20.20.50.9-0.40.9-0.90.9-1.01.0-1.11.41.8
Mean num. licks in bursts0.00.10.60.50.30.2-0.20.2-0.10.1-0.30.3-0.10.2-0.8
Cd content in liver0.91.01.9-0.4-0.4-0.20.7-1.31.2-1.11.4-1.21.1-1.30.4
Co content in liver0.10.10.50.30.30.60.1-0.30.2-0.3-0.1-0.10.30.20.7
Cu content in liver0.20.20.6-0.7-0.7-0.60.8-0.50.1-0.30.2-0.20.5-0.2-0.2
Fe content in liver0.20.20.5-0.6-0.7-0.70.5-0.20.4-0.40.5-0.40.3-0.6-0.3
K content in liver1.21.22.6-0.9-0.9-1.10.8-1.11.0-1.01.1-1.11.0-1.0-1.6
Mg content in liver3.03.34.5-1.0-1.2-1.41.3-2.11.9-2.02.0-2.02.1-1.9-2.1
Mn content in liver3.43.98.7-0.9-1.3-1.51.6-2.02.0-2.02.1-2.12.2-2.1-3.0
Na content in liver0.40.40.9-0.3-0.4-0.30.6-0.80.7-0.60.9-0.90.5-1.0-0.5
Rb content in liver0.40.41.10.20.10.20.2-0.90.8-0.80.8-0.80.7-1.00.2
Se content in liver0.10.10.40.60.30.30.1-0.10.1-0.10.2-0.20.3-0.0-0.6
Sr content in liver0.80.71.50.30.40.5-0.30.9-1.01.0-1.21.1-0.81.10.6
Zn content in liver1.41.63.3-1.3-1.4-1.41.7-1.10.9-1.10.9-0.91.4-0.8-1.8
Bone: minimum diameter2.34.417.5-4.2-3.6-3.62.5-0.00.1-0.20.5-0.20.2-0.1-1.3
Time in familiar zone, hab. session 10.20.21.2-1.1-0.8-0.70.50.0-0.00.0-0.00.1-0.2-0.10.4
Time in novel zone, hab. session 10.10.10.60.80.60.3-0.50.00.0-0.0-0.1-0.00.20.1-0.7
Total zone transitions, hab. session 10.71.02.11.01.00.9-0.81.1-1.10.9-1.11.2-0.61.4-0.1
Total locomotion distance, hab. session 11.21.72.61.51.41.2-1.61.4-1.51.3-1.21.4-1.11.20.2
Locomotion velocity, hab. session 11.11.62.41.51.41.2-1.51.3-1.41.2-1.21.3-1.01.20.4
Time in familiar zone, hab. session 20.20.20.7-0.8-0.6-0.60.10.5-0.50.5-0.30.3-0.70.20.4
Time in novel zone, hab. session 20.91.02.10.30.0-0.10.4-1.31.2-1.21.0-1.11.4-0.9-1.2
Total zone transitions, hab. session 21.11.52.71.61.31.3-0.71.3-1.11.0-1.41.3-0.71.6-0.5
Total locomotion distance, hab. session 22.53.35.32.32.12.0-2.01.8-1.91.8-1.81.8-1.51.60.4
Locomotion velocity, hab. session 22.12.75.42.32.11.9-1.91.6-1.61.6-1.61.5-1.31.40.3
Novel to familiar place preference ratio0.40.51.9-1.4-1.1-1.10.60.5-0.50.5-0.20.2-0.40.4-0.1
Novelty place preference0.30.41.4-1.2-1.0-1.00.80.3-0.30.3-0.10.0-0.10.3-0.2
Time in novel zone, NPP test0.30.41.4-1.2-1.0-1.00.70.2-0.20.2-0.0-0.0-0.10.1-0.3
Total zone transitions, NPP test0.50.71.71.30.90.6-0.71.0-0.80.7-0.90.8-0.20.5-1.2
Total locomotion distance, NPP test0.81.12.61.61.30.9-1.50.9-1.11.0-1.01.0-0.40.4-0.9
Locomotion velocity, NPP test1.42.03.82.01.71.3-1.71.4-1.51.5-1.41.5-0.90.9-0.5
Intraocular pressure0.50.92.10.0-0.1-0.10.11.5-1.11.1-1.21.2-1.01.2-0.4
Delta distance traveled before/after self-admin0.10.10.70.10.1-0.1-0.30.4-0.60.3-0.20.3-0.20.3-0.8
Delta ambulatory time before/after self-admin0.20.41.2-1.1-0.9-1.10.4-0.3-0.0-0.30.4-0.30.3-0.3-0.9
Parametrial fat weight0.81.83.5-1.3-1.1-1.11.2-1.91.5-1.61.2-1.41.4-1.5-0.5
Pavlov. Cond. lever latency2.53.15.6-1.4-1.6-1.51.6-1.91.9-1.92.1-2.01.7-2.4-1.1
Pavlov. Cond. magazine entry latency0.40.51.3-0.00.30.1-1.10.6-0.60.9-0.80.7-0.80.70.7
Pavlov. Cond. change in total contacts1.01.12.40.30.60.5-1.11.2-1.11.2-1.31.2-1.11.50.8
Pavlov. Cond. index score0.91.21.90.30.70.6-1.21.1-1.21.3-1.41.3-1.11.41.0
Pavlov. Cond. latency score1.41.83.20.61.00.9-1.41.4-1.41.5-1.61.5-1.41.81.1
Pavlov. Cond. lever contacts1.82.24.41.11.31.3-1.31.5-1.61.7-1.71.7-1.42.11.0
Pavlov. Cond. magazine entry number0.20.30.70.3-0.1-0.00.7-0.40.4-0.70.7-0.60.6-0.5-0.8
Pavlov. Cond. intertrial magazine entries1.01.22.3-1.0-1.0-1.01.01.5-1.21.1-1.11.1-1.21.0-0.8
Pavlov. Cond. lever-magazine prob. diff.0.60.71.40.10.50.3-0.90.9-0.91.1-1.11.0-0.91.20.6
Pavlov. Cond. response bias0.20.30.6-0.00.30.1-0.70.4-0.50.7-0.80.6-0.40.70.4
Pavlov. Cond. lever latency0.91.33.21.51.51.8-1.10.4-0.60.8-0.80.7-0.61.11.8
Pavlov. Cond. magazine entry latency0.10.10.6-0.0-0.10.00.30.1-0.20.1-0.10.1-0.1-0.60.8
Pavlov. Cond. change in total contacts0.30.82.0-1.3-1.3-1.40.9-0.10.3-0.50.7-0.60.3-0.9-1.0
Pavlov. Cond. index score0.60.92.2-1.4-1.4-1.51.1-0.20.4-0.60.6-0.60.4-1.1-0.8
Pavlov. Cond. latency score0.50.81.9-1.2-1.3-1.41.1-0.10.3-0.40.5-0.50.3-1.1-0.8
Pavlov. Cond. lever contacts0.81.13.3-1.3-1.3-1.60.9-0.40.6-0.70.8-0.70.6-1.0-1.8
Pavlov. Cond. magazine entry number0.10.10.2-0.2-0.0-0.2-0.3-0.30.3-0.20.1-0.10.20.4-0.5
Pavlov. Cond. intertrial magazine entries0.20.31.0-1.0-0.8-1.00.2-0.40.3-0.3-0.0-0.10.4-0.2-0.9
Pavlov. Cond. lever-magazine prob. diff.0.50.82.0-1.3-1.4-1.41.1-0.20.4-0.50.6-0.50.4-1.0-0.7
Pavlov. Cond. response bias0.91.22.7-1.4-1.5-1.61.2-0.50.7-0.80.9-0.80.7-1.1-1.5
Time in closed arm before self-admin1.72.94.81.61.61.3-1.71.8-1.81.6-2.22.1-1.52.1-0.2
Time in closed arm after self-admin1.01.22.01.11.21.2-1.11.0-1.00.9-1.41.3-0.91.30.4
Time in open arm before self-admin0.70.94.40.60.71.1-0.60.8-0.90.8-0.70.7-0.80.72.1
Time in open arm after self-admin0.10.10.9-0.0-0.10.20.40.4-0.10.3-0.00.1-0.30.10.9
Bone: periosteal estimation1.94.618.0-4.2-3.7-3.82.3-0.30.5-0.41.0-0.70.4-0.8-1.2
Bone: periosteal perimeter1.42.810.8-3.3-2.9-2.82.2-0.10.4-0.20.7-0.50.2-0.4-0.8
Bone: post-yield work0.71.34.6-2.2-1.9-1.71.7-0.30.3-0.40.3-0.30.6-0.0-0.5
Progressive ratio test 1 active lever presses1.93.45.71.61.61.4-1.92.4-2.02.2-2.12.0-1.82.00.4
Progressive ratio test 1 breakpoint1.83.05.11.41.51.3-1.82.3-1.92.1-2.01.9-1.71.90.2
Progressive ratio test 1 inactive lever presses1.02.54.80.80.90.7-1.22.0-2.22.1-2.12.0-1.12.0-0.7
Progressive ratio test 2 active lever presses0.50.81.60.70.70.6-0.71.2-1.11.3-0.80.8-1.00.70.5
Progressive ratio test 2 breakpoint0.60.81.80.70.70.6-0.81.3-1.21.3-0.80.8-1.10.70.5
Progressive ratio test 2 inactive lever presses0.10.41.00.50.40.4-0.20.8-1.00.9-0.80.7-0.50.7-0.2
Incentive Sensitization - Responses0.10.21.30.00.00.1-0.00.5-0.50.7-0.10.1-0.7-0.01.1
Incentive Sensitization - Breakpoint0.10.21.5-0.0-0.00.10.00.4-0.40.6-0.00.0-0.7-0.11.2
Sum of active levers in priming session hrs 5-61.01.02.11.31.31.2-1.40.8-0.91.0-0.50.6-0.70.50.8
Progressive ratio0.10.21.3-0.5-0.4-0.20.6-0.20.1-0.00.2-0.1-0.2-0.11.1
Food seeking constrained by brief footshock0.50.61.2-1.0-0.9-0.80.6-0.80.9-1.10.7-0.60.8-0.10.0
Seeking ratio, punishment vs. effort0.00.10.60.10.1-0.1-0.40.20.0-0.1-0.20.20.20.3-0.7
Retroperitoneal fat weight2.410.813.22.53.13.2-3.43.0-3.43.4-3.33.3-3.43.63.6
Reaction time number correct0.31.11.8-0.5-0.8-0.71.1-1.01.3-1.21.4-1.30.9-1.3-1.1
Reaction time mean minus median0.00.31.60.30.70.7-0.7-0.3-0.10.1-0.00.0-0.00.51.3
Reaction time mean minus median AUC0.10.81.4-0.6-0.5-0.60.3-1.21.1-1.21.2-1.20.9-0.8-0.4
Reaction time num false alarms0.50.81.6-0.9-0.9-0.90.51.2-1.11.1-1.01.0-0.80.6-0.4
Reaction time num false alarms AUC0.30.81.8-1.3-1.2-1.30.80.8-0.70.7-0.70.7-0.30.3-0.8
Reaction time trials correct on left0.31.11.8-0.5-0.8-0.71.1-1.01.3-1.21.4-1.30.9-1.3-1.1
Reaction time trials on left0.41.32.0-0.6-0.9-0.81.1-1.11.4-1.31.4-1.30.9-1.3-1.1
Reaction time mean0.30.61.6-0.4-0.2-0.2-0.2-1.31.0-0.90.9-0.90.9-0.90.5
Reaction time mean AUC0.20.51.3-0.10.1-0.0-0.4-1.20.9-0.80.8-0.80.8-0.70.5
Median of all reaction times0.60.92.2-0.5-0.4-0.5-0.0-1.51.3-1.11.1-1.11.1-1.20.2
Reaction time omissions0.30.51.3-0.6-0.4-0.6-0.3-1.10.8-0.90.8-0.71.0-0.50.2
Reaction time false alarm rate0.70.91.9-0.7-0.6-0.60.11.2-1.31.3-1.41.3-0.80.90.0
Reaction time premature initiation rate0.91.52.80.00.20.3-0.81.7-1.71.6-1.41.5-1.41.01.2
Reaction time premature initiations0.10.20.5-0.6-0.5-0.50.10.7-0.50.5-0.30.3-0.5-0.00.2
Std. dev. reaction times0.20.61.9-0.4-0.1-0.2-0.1-1.40.9-0.90.9-0.91.1-0.60.5
Reaction time trials completed0.41.32.0-0.6-0.9-0.81.1-1.11.4-1.31.4-1.30.9-1.3-1.1
Reaction time trials AUC0.31.11.9-0.5-0.7-0.70.9-1.01.3-1.21.4-1.30.8-1.3-0.9
Run reversals in cocaine runway, females6.06.714.42.22.73.0-2.32.0-2.32.3-2.52.4-2.52.53.8
Run reversals in cocaine runway, males0.20.20.5-0.6-0.5-0.40.7-0.60.3-0.30.2-0.20.7-0.10.2
Latency to leave start box in cocaine runway3.14.39.02.82.72.5-3.01.8-1.51.6-1.81.8-2.01.21.4
Latency to leave start box in cocaine runway, F5.06.28.32.82.72.8-2.92.5-2.12.2-2.52.4-2.52.12.3
Latency to leave start box in cocaine runway, M0.60.62.31.31.30.9-1.50.1-0.10.2-0.10.2-0.1-0.3-0.6
Std. dev. time between licks in bursts0.40.71.91.41.31.4-0.90.4-0.40.5-0.50.4-0.40.40.9
Total sessions with >9 infusions1.72.13.91.61.41.3-1.12.0-1.61.6-1.61.6-1.31.40.1
Short access day 1 total inactive lever presses0.10.30.90.40.30.3-0.10.8-0.60.5-0.40.4-1.00.30.4
Short access day 10 total inactive lever presses0.00.10.3-0.3-0.3-0.30.6-0.50.0-0.00.2-0.20.5-0.2-0.2
Short access day 1 total infusions0.81.53.41.51.21.1-0.81.9-1.31.3-1.21.2-1.31.1-0.3
Short access day 10 total infusions1.32.24.30.70.70.5-0.92.1-1.81.9-1.91.8-1.21.8-1.0
Short access total infusions0.40.61.70.50.30.1-0.11.3-0.90.9-0.90.9-0.50.8-1.3
Short access day 1 locomotion3.25.28.92.02.01.9-2.13.0-2.52.4-2.52.5-2.52.40.9
Short access day 10 total locomotion0.41.43.50.10.20.2-0.21.5-1.61.3-1.91.8-1.01.7-0.3
Short access total locomotion2.53.86.61.41.51.4-1.42.6-2.32.1-2.52.4-1.82.30.3
One hour access (0.3 mA shock)0.30.41.3-1.1-1.0-1.10.50.10.1-0.10.4-0.40.0-0.5-0.6
Compulsive drug intake0.71.13.3-1.8-1.6-1.70.8-0.80.6-0.40.9-0.80.2-0.8-0.7
One hour access (shock baseline)0.00.00.10.1-0.0-0.00.10.3-0.20.3-0.20.20.20.1-0.2
Social response proportion0.40.51.6-1.3-1.0-1.00.7-0.70.4-0.40.3-0.41.00.00.2
Social responses0.20.30.7-0.3-0.2-0.4-0.50.7-0.90.8-0.70.7-0.20.7-0.1
Social time0.61.02.5-1.5-1.3-1.11.6-1.00.8-0.70.5-0.61.00.1-0.4
Soleus weight0.10.31.7-0.5-0.3-0.00.60.6-0.60.4-0.20.5-0.31.30.5
Bone: stiffness0.30.52.0-1.4-1.1-1.10.7-0.50.4-0.30.5-0.30.4-0.50.1
Tibialis anterior weight1.13.97.51.51.92.1-1.81.8-1.92.0-1.82.0-1.92.72.2
Time to tail flick, vehicle, before self-admin0.50.60.9-0.8-0.7-0.51.0-1.00.8-0.70.8-0.70.7-0.90.6
Time to tail flick, vehicle, after self-admin0.30.61.3-1.0-1.0-0.71.1-0.70.5-0.50.8-0.90.6-0.70.6
Time to tail flick, test, before self-admin0.40.52.5-1.6-1.2-1.10.9-0.1-0.20.1-0.20.2-0.10.20.2
Time to tail flick, test, after self-admin0.40.41.4-1.2-1.0-1.10.8-0.30.2-0.00.0-0.10.2-0.0-0.5
Delta time to tail flick, vehicle, before/after SA0.60.61.1-1.0-1.0-1.00.7-0.70.7-0.70.8-0.80.6-0.6-0.4
Delta time to tail flick, test, before/after SA0.60.71.2-0.7-0.9-0.91.0-0.81.1-0.90.7-0.80.9-0.8-0.7
Tibia length1.33.55.11.11.51.6-1.52.0-2.22.3-1.92.0-2.11.92.1
Ambulatory time before self-admin0.51.43.01.71.61.7-1.50.7-0.70.9-0.70.7-0.60.61.6
Ambulatory time after self-admin0.30.51.50.60.80.7-1.20.6-0.70.7-0.50.5-0.60.41.0
Bone: tissue strength0.10.20.50.60.20.20.2-0.10.3-0.30.3-0.30.4-0.5-0.7
Total heroin consumption0.10.10.20.10.1-0.1-0.3-0.30.0-0.00.4-0.40.2-0.5-0.1
Bone: trabecular number5.39.911.9-2.7-3.0-3.13.1-3.13.3-3.33.4-3.33.2-2.8-3.4
Bone: trabecular spacing3.34.86.32.02.22.3-2.52.0-2.32.3-2.12.1-2.21.62.5
Bone: trabecular thickness2.02.85.2-2.2-2.2-2.32.1-1.11.2-1.21.2-1.21.4-1.0-2.1
Bone: trabecular tissue density0.91.62.61.31.41.5-1.30.9-1.21.3-1.21.2-1.20.61.6
Water consumed over 24 hours1.02.04.62.22.01.8-2.01.1-1.11.1-1.11.1-1.01.00.6
Number of responses in last shaping day1.31.72.61.41.41.4-0.71.3-1.61.4-1.61.5-0.71.40.1