Slc16a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Slc16a3	0.05	0.04	1.4e-03	0.02	0.03	0.02	0.02	4.3e-03	5.7e-04	2.8e-03	9.6e-04
2	LHb	gene expression	Slc16a3	0.42	0.31	6.4e-03	0.04	0.02	0.03	0.01	4.8e-02	1.2e-01	5.6e-02	2.1e-01
3	NAcc	gene expression	Slc16a3	0.29	0.1	0.0e+00	0.29	0.28	0.27	0.29	3.7e-34	1.5e-32	9.4e-31	7.2e-34
4	BLA	gene expression	Slc16a3	0.05	0.04	4.8e-03	0.03	0.04	0.03	0.03	6.3e-03	3.4e-03	6.7e-03	9.2e-03
5	Brain	gene expression	Slc16a3	0.03	0.03	9.1e-03	0.01	0.02	0.01	0.01	1.2e-02	3.8e-03	4.6e-02	1.3e-02
6	Brain	mRNA stability	Slc16a3	0.06	0.04	1.1e-04	0.04	0.04	0.04	0.04	4.7e-05	5.9e-05	5.4e-05	6.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.4	0.7	-0.4	0.7	0.5	-0.6	-0.8	0.8
Area under the delay curve	1.4	1.5	2.4	1.2	-1.6	-1.4	1.4	0.9	-0.8
BMI with tail	0.9	2.8	5.1	-2.3	1.8	1.4	-1.1	-1.4	1.8
BMI without tail	8.6	17.7	22.7	-3.4	4.0	4.3	-4.4	-4.8	4.3
Body weight	3.8	16.1	25.9	-5.1	4.6	4.2	-3.6	-3.2	3.0
Weight adjusted by age	1.7	1.9	3.7	-1.9	1.7	1.4	-1.3	-0.7	0.8
Bone surface	0.2	0.3	0.6	-0.3	0.8	0.6	-0.8	-0.5	0.4
Bone volume	0.3	0.5	0.7	-0.4	0.8	0.7	-0.8	-0.7	0.6
Breakpoint value in progressive ratio session	0.2	0.3	0.6	-0.8	0.5	0.2	-0.0	0.6	-0.5
Number of licking bursts	0.3	0.4	1.0	-0.0	0.6	0.4	-0.6	-0.8	1.0
Context. condit. distance diff. score	1.8	2.2	5.2	-0.4	1.0	1.0	-1.3	-2.0	2.3
Locomotion velocity, session 1	3.5	3.8	5.3	1.2	-2.0	-1.8	2.0	2.3	-2.3
Locomotion distance, session 1	1.6	2.0	3.4	1.7	-1.8	-1.7	1.6	0.6	-0.0
Locomotion velocity, session 2	4.7	5.5	7.4	2.3	-2.7	-2.6	2.6	2.1	-1.7
Locomotion distance, session 2	0.2	0.3	0.4	0.5	-0.6	-0.5	0.4	-0.4	0.6
Locomotion velocity, session 3	2.5	2.9	3.8	1.3	-1.7	-1.8	1.9	1.9	-1.6
Locomotion distance, session 3	3.2	3.5	4.8	1.8	-2.1	-2.1	2.2	1.7	-1.2
Stereotopy head waving bouts, day 3	0.9	1.0	1.4	0.6	-1.0	-1.0	1.1	1.2	-1.1
Stereotopy head waving duration, day 3	0.4	0.5	0.6	0.4	-0.7	-0.7	0.8	0.7	-0.6
Locomotion velocity, session 7	0.7	0.7	1.4	1.2	-0.9	-1.1	0.9	0.6	-0.2
Locomotion distance, session 7	1.7	2.1	4.6	2.1	-1.7	-1.7	1.4	0.3	0.5
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	-0.6	0.5	0.3	-0.3	-0.3	0.4
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.7	0.7	0.5	-0.5	-0.3	0.3
Locomotion velocity, session 8	0.3	0.3	0.9	0.4	-0.6	-0.3	0.3	-0.6	0.9
Locomotion distance, session 8	1.8	2.6	8.3	-0.1	0.6	0.7	-1.0	-2.3	2.9
Degree of sensitization distance	1.3	1.3	2.1	-0.4	0.9	1.0	-1.3	-1.5	1.4
Degree of sensitization stereotypy	0.5	0.5	0.8	-0.9	0.8	0.6	-0.6	-0.6	0.7
Conditioned locomotion	5.6	6.5	7.3	-2.2	2.6	2.7	-2.7	-2.7	2.4
Cocaine response after cond. corrected	0.2	0.3	0.9	0.0	-0.4	-0.2	0.4	0.6	-0.9
Cocaine response after cond. not corrected	0.6	0.7	1.2	0.6	-0.9	-0.6	0.8	0.9	-1.1
Cocaine response before conditioning	0.6	0.7	1.4	1.2	-0.9	-1.0	0.8	0.3	0.1
Saline control response	3.0	3.9	5.1	-2.0	2.3	2.2	-2.2	-1.8	1.3
Bone: connectivity density	0.2	0.4	1.2	0.4	0.1	0.1	-0.4	-0.8	1.1
Bone: cortical apparent density	2.8	3.7	4.4	1.9	-2.1	-2.1	2.1	1.8	-1.4
Bone: cortical area	5.5	8.3	20.5	-4.5	3.4	3.0	-2.1	-1.6	1.2
Bone: cortical porosity	1.1	1.2	3.8	-1.2	0.5	0.5	0.1	1.3	-1.9
Bone: cortical porosity	0.9	1.0	2.1	-1.3	0.8	0.7	-0.3	0.8	-1.4
Bone: cortical thickness	4.4	7.2	23.6	-4.9	3.1	2.7	-1.5	-0.8	0.3
Bone: cortical thickness	1.6	1.9	7.0	-2.7	1.5	1.2	-0.6	-0.4	0.2
Bone: cortical tissue density	3.2	4.3	5.0	2.1	-2.2	-2.2	2.2	2.0	-1.5
Condit. Reinf. active minus inactive responses	2.5	2.8	3.5	-1.8	1.8	1.9	-1.8	-1.5	1.2
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.5	-1.2	1.2	1.1	-1.0	-0.8	0.7
Condit. Reinf. active responses	4.7	5.8	7.1	-2.4	2.5	2.7	-2.6	-2.3	1.8
Condit. Reinf. inactive responses	1.4	1.6	2.3	-1.1	1.2	1.5	-1.5	-1.3	0.9
Incentive salience index mean	2.1	2.5	3.0	-1.4	1.7	1.7	-1.7	-1.6	1.3
Condit. Reinf. lever presses	0.2	0.3	0.8	0.4	0.2	0.1	-0.4	-0.7	0.9
Condit. Reinf. active minus inactive responses	1.2	1.5	2.7	-1.6	1.0	1.4	-1.1	-1.1	0.9
Condit. Reinf. active-inactive response ratio	2.1	2.2	4.7	-2.2	1.5	1.7	-1.4	-1.0	0.4
Condit. Reinf. active responses	0.5	0.6	1.0	-1.0	0.5	0.9	-0.7	-0.9	0.8
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.6	-0.7	-0.6	0.6	0.2	0.1
Condit. Reinf. lever presses	0.4	0.6	1.0	-0.4	0.5	0.7	-0.7	-1.0	1.0
Condit. Reinf. lever reinforcers received	0.5	0.7	1.1	-0.9	0.5	0.9	-0.8	-1.1	1.0
Conditioned reinforcement - actives	0.2	0.2	0.7	0.2	0.3	0.3	-0.3	-0.7	0.9
Conditioned reinforcement - inactives	0.9	1.0	1.8	-1.3	1.0	1.3	-1.1	-0.7	0.4
Conditioned locomotion	0.1	0.1	0.2	0.1	0.4	0.1	-0.2	-0.3	0.4
Patch foraging indifference point 0 sec	0.0	0.1	0.3	-0.1	0.5	0.1	-0.3	-0.2	0.1
Patch foraging indifference point AUC	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.3	-0.4	0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.0	-0.2	-0.4	0.4	0.3	0.0
Delay disc. indifference point, 16s delay	1.1	1.1	2.5	1.6	-1.3	-1.1	1.0	0.1	0.2
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	0.5	-0.8	-0.8	0.8	0.7	-0.7
Delay disc. indifference point, 24s delay	6.0	5.8	7.0	2.2	-2.6	-2.5	2.6	2.4	-2.0
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	0.4	-0.8	-0.7	0.8	0.6	-0.6
Delay disc. indifference point, 8s delay	1.1	1.2	1.5	0.6	-1.2	-1.1	1.2	1.2	-1.2
Indifference point function ln k	0.7	1.0	1.7	1.0	-0.9	-1.3	1.3	0.8	-0.4
Indifference point function log k	0.7	1.0	1.7	1.0	-0.9	-1.3	1.3	0.8	-0.4
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.2	0.5	0.2	-0.4	-0.3	0.2
Patch foraging total patch changes 12 sec	0.0	0.0	0.2	-0.1	0.0	0.1	-0.2	0.0	-0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.4	-0.1	-0.1	-0.2	-0.5	0.6
Patch foraging total patch changes 24 sec	0.5	0.6	1.0	-0.7	1.0	0.6	-0.9	-0.7	0.5
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.6	0.7	0.6	-0.7	-0.3	-0.1
Patch foraging time to switch 0 sec	0.5	0.7	1.3	1.1	-0.9	-1.0	0.8	0.8	-0.6
Patch foraging water rate 0 sec	2.5	4.0	4.7	-2.1	2.1	2.2	-2.0	-2.0	1.7
Patch foraging water rate 12 sec	0.6	0.9	1.7	-1.1	0.7	0.8	-0.5	-1.1	1.3
Patch foraging water rate 18 sec	1.2	1.6	3.0	-1.0	1.0	1.1	-1.0	-1.5	1.7
Patch foraging water rate 24 sec	3.0	4.2	5.8	-1.8	1.9	1.9	-1.8	-2.3	2.4
Patch foraging water rate 6 sec	0.3	0.5	1.1	-0.9	0.3	0.5	-0.1	-0.6	1.0
Seeking ratio, delayed vs. immediate footshock	1.7	1.9	2.2	-1.4	1.4	1.4	-1.5	-1.3	1.2
Distance traveled before self-admin	0.6	0.6	1.4	-1.2	1.2	0.6	-0.6	0.2	-0.3
Distance traveled after self-admin	0.8	0.9	1.5	-0.1	1.0	0.8	-1.2	-1.1	0.8
Extensor digitorum longus weight	0.4	1.5	4.6	-0.1	0.7	0.6	-0.9	-1.7	2.1
Bone: elastic displacement	0.9	1.0	2.2	-1.5	1.3	1.1	-0.9	-0.3	-0.0
Bone: elastic work	4.9	6.3	16.1	-4.0	3.1	2.8	-2.0	-0.6	-0.4
Bone: endosteal estimation	0.2	0.5	1.5	0.4	0.3	0.3	-0.6	-1.0	1.2
Bone: endosteal perimeter	0.5	1.1	1.9	-0.8	1.4	1.1	-1.2	-0.9	0.6
Epididymis fat weight	1.3	2.9	3.8	-1.4	2.0	1.6	-1.6	-1.7	1.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.4	-0.3	-0.1	0.0	-0.4	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.1	0.4	-0.1	-0.0	-0.1	0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	0.9	0.9	-0.5	-0.7	0.7	0.8	-0.3
Delay discount exponential model param	2.2	2.4	3.5	-1.4	1.9	1.6	-1.7	-1.3	1.2
Extinction: sum of active levers before priming	2.2	2.2	3.6	1.0	-1.2	-1.6	1.8	1.9	-1.1
Active lever presses in extinction session 6	1.4	1.4	3.0	0.0	-0.7	-1.0	1.4	1.7	-1.3
Bone: final force	5.4	8.7	20.3	-4.5	3.4	3.2	-2.3	-1.9	1.4
Bone: final moment	5.9	9.5	22.3	-4.7	3.6	3.3	-2.4	-1.8	1.2
Food consumed during 24 hour testing period	0.4	0.4	0.7	-0.3	0.8	0.7	-0.8	-0.7	0.5
Glucose	5.9	8.9	15.8	1.1	-2.6	-2.4	3.0	3.9	-4.0
Heart weight	0.5	0.7	2.4	-1.6	0.9	0.8	-0.5	-0.3	0.3
Delay discount hyperbolic model param	2.1	2.3	3.4	-1.4	1.8	1.6	-1.6	-1.3	1.2
Intermittent access intake day 1-15 change	0.6	0.6	1.3	-0.7	0.7	1.0	-1.2	-0.7	0.3
Intermittent access intake escalation	0.6	0.6	1.4	-0.5	0.7	0.9	-1.2	-0.9	0.4
Intermittent access intake escalation 2	0.9	0.9	1.8	-1.3	1.1	1.0	-1.2	-0.3	0.1
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.3	-1.2	0.8	0.9	-0.9	-0.4	0.1
Intermitt. access day 15 inactive lever presses	1.2	1.3	1.7	-0.9	1.1	1.1	-1.2	-1.3	1.1
Intermitt. access escalation Index	1.7	1.5	2.6	-0.3	1.2	1.1	-1.3	-1.6	1.4
Intermittent access day 1 total infusions	0.5	0.6	0.8	-0.7	0.8	0.9	-0.8	-0.8	0.6
Intermittent access day 15 total infusions	0.9	1.0	1.5	-0.7	1.0	1.1	-1.2	-1.1	0.8
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.0	-0.9	1.3	1.3	-1.4	-1.1	0.8
Intermittent access total infusions	0.8	0.9	1.1	-0.7	0.9	1.0	-1.1	-1.0	0.8
Intermittent access day 1 locomotion	0.5	0.6	0.8	-0.6	0.7	0.9	-0.6	-0.9	0.7
Intermittent access day 15 total locomotion	0.4	0.4	0.7	-0.7	0.7	0.8	-0.7	-0.5	0.2
Intermittent access total locomotion	0.4	0.5	0.7	-0.8	0.8	0.8	-0.7	-0.7	0.4
Intermittent access standard deviation	1.1	1.2	2.6	0.2	-0.7	-1.0	1.1	1.6	-1.4
Left kidney weight	0.1	0.3	1.3	-1.1	0.2	0.1	0.4	0.5	-0.4
Right kidney weight	0.1	0.2	0.7	-0.8	-0.1	-0.1	0.6	0.3	0.1
Cocaine induced anxiety	2.3	2.7	7.7	-2.8	2.0	1.6	-1.2	0.2	-0.6
Post-drug Anxiety	0.4	0.5	1.4	-1.2	0.4	0.2	-0.1	0.6	-1.0
Baseline Anxiety	5.1	5.4	8.7	2.9	-2.9	-2.7	2.5	1.2	-0.9
Tail length	6.7	20.4	26.0	-3.7	4.6	5.0	-5.1	-4.8	3.7
Length with tail	2.0	7.2	11.0	-3.3	3.2	3.1	-2.6	-1.9	1.3
Length without tail	1.4	3.1	6.8	-0.5	-0.8	-1.3	2.0	2.6	-2.3
Times rat made contact with spout	0.6	0.6	1.2	-0.6	0.9	0.9	-1.1	0.1	-0.9
Lifetime Intake	0.2	0.3	0.4	-0.2	0.5	0.6	-0.6	-0.6	0.5
Liver weight, left	0.5	0.8	1.9	-0.1	-0.4	-0.6	0.9	1.4	-1.3
Liver weight, right	1.4	2.4	3.6	-1.9	1.9	1.7	-1.4	-1.1	0.9
Locomotor activity	0.7	1.2	1.9	1.1	-1.1	-1.4	1.1	1.0	-0.7
Locomotor testing distance	0.9	1.4	2.7	1.6	-1.1	-1.6	1.2	0.7	-0.2
Locomotor testing rearing	0.3	0.5	1.6	1.3	-0.6	-0.8	0.5	0.1	0.2
Locomotion in novel chamber	0.2	0.2	0.5	0.5	-0.5	-0.7	0.4	0.0	0.4
Locomotion in novel chamber post-restriction	2.5	3.0	4.2	-1.8	1.7	2.0	-2.0	-1.6	1.2
Fecal boli incidents, locomotor time 1	0.4	0.4	1.0	1.0	-0.8	-0.6	0.6	0.3	-0.2
Change in fecal boli incidents, locomotor task	3.0	2.9	4.0	1.2	-1.6	-1.6	1.6	2.0	-2.0
Time >=10cm from walls, locomotor time 1	1.7	1.7	3.1	-0.4	1.1	1.1	-1.4	-1.8	1.7
Bouts of movement, locomotor time 1	1.7	1.9	2.3	1.4	-1.4	-1.4	1.5	1.3	-1.1
Total resting periods, locomotor time 1	2.3	2.5	3.0	1.5	-1.6	-1.6	1.7	1.6	-1.4
Rest time, locomotor task time 1	0.5	0.5	1.0	0.5	-0.6	-0.6	0.6	0.9	-1.0
Distance moved, locomotor task time 1	0.7	0.8	1.1	-0.6	1.1	0.9	-0.8	-1.0	1.0
Vertical activity count, locomotor time 1	1.8	1.9	3.2	-0.8	1.5	1.2	-1.2	-1.5	1.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.6	0.1	0.3	-0.2	-0.5	0.5
Bouts of movement, locomotor time 2	0.8	0.8	1.4	1.1	-1.2	-1.0	1.0	0.5	-0.4
Total resting periods, locomotor time 2	0.4	0.5	1.0	1.0	-0.9	-0.6	0.7	0.1	0.0
Rest time, locomotor task time 2	0.1	0.1	0.5	0.7	-0.2	-0.1	0.0	0.1	-0.1
Distance moved, locomotor task time 2	0.0	0.1	0.2	-0.5	0.2	0.1	0.1	-0.1	0.2
Vertical activity count, locomotor time 2	0.4	0.5	1.3	-0.6	0.5	0.4	-0.3	-0.9	1.1
Light reinforcement 1	1.8	3.3	6.3	-0.9	1.9	1.4	-1.8	-2.1	2.5
Light reinforcement 2	2.5	3.3	4.5	-1.5	2.1	1.7	-1.8	-1.8	2.0
Bone: marrow area	0.2	0.5	1.4	0.4	0.2	0.3	-0.6	-1.0	1.2
Bone: maximum diameter	1.3	2.4	4.8	-2.2	2.0	1.5	-1.3	-1.0	0.9
Bone: maximum force	5.8	9.9	21.8	-4.7	3.5	3.4	-2.5	-2.2	1.7
Bone: maximum moment	6.2	10.7	23.6	-4.9	3.7	3.6	-2.7	-2.1	1.6
Mean time between licks in bursts	1.2	1.7	2.5	1.6	-1.6	-1.5	1.4	0.9	-0.6
Mean num. licks in bursts	0.3	0.3	1.3	-0.3	0.1	0.2	-0.2	0.6	-1.1
Cd content in liver	1.2	1.4	2.3	1.1	-1.5	-1.3	1.4	0.8	-0.4
Co content in liver	0.2	0.2	0.6	0.7	-0.3	-0.6	0.3	0.2	-0.1
Cu content in liver	0.4	0.4	1.5	-0.5	0.3	0.2	0.1	0.8	-1.2
Fe content in liver	0.9	1.1	2.2	1.5	-1.1	-1.3	1.0	0.6	-0.3
K content in liver	2.8	2.8	3.8	-0.9	1.7	1.5	-1.9	-1.9	1.8
Mg content in liver	1.5	1.6	4.2	0.3	0.6	0.6	-1.1	-1.8	2.0
Mn content in liver	0.2	0.2	0.6	-0.8	0.6	0.5	-0.4	-0.3	0.2
Na content in liver	0.0	0.0	0.1	0.3	0.1	-0.2	0.0	0.1	-0.0
Rb content in liver	1.7	2.1	2.9	-1.2	1.2	1.4	-1.4	-1.7	1.7
Se content in liver	0.4	0.5	0.9	-0.2	0.7	0.7	-1.0	-0.8	0.6
Sr content in liver	1.3	1.2	3.5	0.1	-0.5	-0.6	0.8	1.6	-1.9
Zn content in liver	0.0	0.0	0.1	0.3	-0.2	-0.0	0.1	0.1	-0.4
Bone: minimum diameter	2.4	4.6	7.8	-2.8	2.8	2.3	-2.0	-1.3	0.9
Time in familiar zone, hab. session 1	0.2	0.1	0.4	-0.3	-0.3	-0.0	0.2	0.4	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.2	0.2	0.1	-0.2	-0.3	0.5
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.4	-0.6	-0.5	0.6	0.1	0.2
Total locomotion distance, hab. session 1	0.2	0.3	1.1	-0.2	0.5	0.3	-0.4	-0.7	1.0
Locomotion velocity, hab. session 1	0.3	0.4	1.1	-0.2	0.6	0.3	-0.4	-0.7	1.1
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.7	-0.4	-0.5	0.3	0.1	0.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2	0.1	-0.0
Total zone transitions, hab. session 2	0.5	0.6	2.3	0.3	-0.3	0.0	-0.2	-1.1	1.5
Total locomotion distance, hab. session 2	1.6	2.1	5.4	-0.4	0.9	1.0	-1.2	-2.0	2.3
Locomotion velocity, hab. session 2	1.9	2.6	5.6	-0.7	1.2	1.2	-1.4	-2.1	2.4
Novel to familiar place preference ratio	1.8	1.9	4.5	-2.1	1.6	1.6	-1.2	-0.3	-0.3
Novelty place preference	1.7	1.8	4.4	-2.1	1.5	1.5	-1.1	-0.2	-0.4
Time in novel zone, NPP test	1.4	1.5	3.7	-1.9	1.4	1.4	-1.0	-0.3	-0.2
Total zone transitions, NPP test	0.7	1.0	3.2	1.0	-0.4	-0.3	-0.1	-1.3	1.8
Total locomotion distance, NPP test	1.4	1.9	6.3	0.3	0.5	0.5	-0.9	-2.0	2.5
Locomotion velocity, NPP test	1.2	1.7	4.9	0.0	0.7	0.6	-1.0	-1.8	2.2
Intraocular pressure	0.9	1.3	1.9	-0.9	0.9	1.4	-1.3	-1.3	0.8
Delta distance traveled before/after self-admin	0.4	0.4	1.3	1.1	-0.4	-0.2	-0.1	-0.7	0.7
Delta ambulatory time before/after self-admin	0.8	0.8	3.2	1.8	-1.0	-0.7	0.4	-0.4	0.3
Parametrial fat weight	1.5	3.0	3.8	-1.7	2.0	2.0	-1.9	-1.4	1.2
Pavlov. Cond. lever latency	0.5	0.6	1.2	0.9	-0.8	-0.6	0.4	-0.6	1.1
Pavlov. Cond. magazine entry latency	1.3	1.6	3.5	-1.9	1.5	1.4	-1.2	-0.0	-0.8
Pavlov. Cond. change in total contacts	0.6	0.6	2.1	-0.5	0.2	-0.0	0.2	1.0	-1.5
Pavlov. Cond. index score	1.7	2.2	3.9	-2.0	1.9	1.7	-1.5	-0.5	-0.2
Pavlov. Cond. latency score	1.2	1.5	2.8	-1.7	1.6	1.4	-1.2	-0.1	-0.5
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.7	0.8	0.6	-0.5	0.1	-0.4
Pavlov. Cond. magazine entry number	1.2	1.5	3.3	1.8	-1.2	-1.2	0.8	-0.5	1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.8	-0.4	0.7	0.9	-1.0	-1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	4.3	-2.1	2.0	1.7	-1.5	-0.4	-0.2
Pavlov. Cond. response bias	1.0	1.3	2.8	-1.7	1.3	1.2	-0.9	0.3	-1.0
Pavlov. Cond. lever latency	1.1	1.5	2.5	0.6	-1.0	-1.0	1.2	1.5	-1.6
Pavlov. Cond. magazine entry latency	1.0	1.2	3.3	1.8	-1.2	-1.2	0.9	0.1	0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.6	-0.2	-0.3	-0.0	-0.5	0.9
Pavlov. Cond. index score	0.2	0.3	0.7	0.7	-0.2	-0.2	-0.1	-0.6	0.8
Pavlov. Cond. latency score	0.3	0.3	1.0	0.6	-0.1	-0.0	-0.2	-0.8	1.0
Pavlov. Cond. lever contacts	1.6	2.2	3.7	-0.7	1.3	1.3	-1.6	-1.8	1.9
Pavlov. Cond. magazine entry number	0.8	0.9	2.8	-1.7	1.0	1.0	-0.7	0.1	-0.6
Pavlov. Cond. intertrial magazine entries	2.0	2.6	3.7	-1.9	1.6	1.9	-1.6	-1.4	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.9	-0.3	-0.3	0.0	-0.5	0.7
Pavlov. Cond. response bias	0.5	0.6	1.7	0.1	0.4	0.5	-0.7	-1.1	1.3
Time in closed arm before self-admin	0.4	0.4	1.0	-0.2	-0.3	-0.4	0.6	1.0	-1.0
Time in closed arm after self-admin	1.5	1.6	3.3	0.4	-1.1	-1.0	1.1	1.6	-1.8
Time in open arm before self-admin	0.1	0.1	0.3	0.6	-0.3	-0.3	0.2	-0.3	0.3
Time in open arm after self-admin	0.1	0.1	0.3	0.4	0.0	-0.3	0.2	-0.2	0.6
Bone: periosteal estimation	2.0	4.2	7.0	-2.6	2.4	2.1	-1.8	-1.6	1.4
Bone: periosteal perimeter	2.2	3.6	8.9	-3.0	2.4	2.0	-1.5	-0.6	0.0
Bone: post-yield work	0.2	0.2	0.8	-0.1	0.0	0.2	-0.2	-0.7	0.9
Progressive ratio test 1 active lever presses	1.5	1.5	1.9	-0.8	1.4	1.4	-1.4	-1.2	1.2
Progressive ratio test 1 breakpoint	1.9	2.0	2.5	-1.0	1.6	1.6	-1.6	-1.4	1.2
Progressive ratio test 1 inactive lever presses	2.8	3.1	3.8	-1.7	1.9	2.0	-1.8	-1.6	1.5
Progressive ratio test 2 active lever presses	0.5	0.5	0.8	-0.6	0.6	0.8	-0.9	-0.7	0.4
Progressive ratio test 2 breakpoint	0.7	0.8	1.2	-0.6	0.8	1.0	-1.1	-1.1	0.7
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.7	-0.8	0.5	0.6	-0.6	-0.4	0.1
Incentive Sensitization - Responses	0.3	0.3	0.7	-0.5	0.4	0.6	-0.8	-0.6	0.1
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.4	0.3	0.5	-0.7	-0.5	-0.0
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.1	-1.0	0.5	0.6	-0.5	0.2	-0.4
Progressive ratio	0.5	0.6	0.9	0.7	-0.9	-0.8	0.8	0.7	-0.5
Food seeking constrained by brief footshock	0.4	0.4	0.8	0.5	-0.6	-0.5	0.6	0.9	-0.7
Seeking ratio, punishment vs. effort	0.2	0.2	0.3	-0.3	0.6	0.5	-0.6	-0.5	0.4
Retroperitoneal fat weight	4.2	13.9	20.5	-3.5	4.5	4.0	-4.0	-3.2	2.9
Reaction time number correct	2.1	3.0	9.8	0.1	0.7	0.7	-1.0	-2.5	3.1
Reaction time mean minus median	0.4	0.5	1.1	0.5	-0.3	-0.6	0.6	1.0	-0.8
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	0.0	-0.1	0.1	0.3	-0.1
Reaction time num false alarms	0.2	0.3	0.4	0.6	-0.4	-0.6	0.5	0.5	-0.4
Reaction time num false alarms AUC	0.5	0.7	1.2	1.1	-0.9	-0.9	0.8	0.6	-0.5
Reaction time trials correct on left	2.1	3.0	9.8	0.1	0.7	0.7	-1.0	-2.5	3.1
Reaction time trials on left	2.2	3.1	10.2	0.2	0.7	0.7	-1.0	-2.5	3.2
Reaction time mean	0.3	0.4	0.6	-0.5	0.7	0.5	-0.6	-0.5	0.8
Reaction time mean AUC	0.4	0.5	1.3	-0.3	0.7	0.5	-0.6	-0.8	1.2
Median of all reaction times	0.4	0.6	1.1	-0.6	0.8	0.7	-0.7	-0.8	1.1
Reaction time omissions	0.2	0.2	0.7	0.3	0.5	0.1	-0.4	-0.6	0.8
Reaction time false alarm rate	1.4	1.9	3.8	0.9	-1.1	-1.1	1.2	1.7	-1.9
Reaction time premature initiation rate	1.3	1.7	3.0	1.3	-1.7	-1.4	1.2	0.9	-1.1
Reaction time premature initiations	0.5	0.7	1.5	1.2	-1.1	-0.8	0.4	-0.5	0.7
Std. dev. reaction times	0.3	0.4	0.7	0.9	-0.6	-0.7	0.6	0.5	-0.1
Reaction time trials completed	2.2	3.1	10.2	0.2	0.7	0.7	-1.0	-2.5	3.2
Reaction time trials AUC	2.2	3.2	10.3	0.1	0.8	0.7	-1.1	-2.5	3.2
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.9	-0.4	-0.8	0.2	-0.2	0.4
Run reversals in cocaine runway, males	0.6	0.6	1.3	-1.1	1.0	0.8	-0.8	0.1	-0.5
Latency to leave start box in cocaine runway	0.1	0.2	0.6	0.8	-0.4	-0.2	0.2	-0.1	0.2
Latency to leave start box in cocaine runway, F	0.3	0.4	0.9	0.9	-0.3	-0.3	0.1	-0.6	1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.0	0.4	-0.3	-0.1	-0.2
Std. dev. time between licks in bursts	2.4	2.9	7.5	-0.4	1.1	1.1	-1.3	-2.3	2.7
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	-0.5	-0.4	0.4	0.1	0.1
Short access day 1 total inactive lever presses	0.2	0.3	0.8	0.3	0.1	0.0	-0.2	-0.8	0.9
Short access day 10 total inactive lever presses	2.9	3.2	5.8	-2.4	1.8	2.0	-1.9	-1.4	0.7
Short access day 1 total infusions	1.6	1.7	2.3	1.4	-1.3	-1.5	1.5	1.2	-0.7
Short access day 10 total infusions	0.4	0.5	0.9	-0.6	0.7	0.9	-0.8	-0.5	0.3
Short access total infusions	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	-0.1	0.2
Short access day 1 locomotion	0.7	0.7	1.1	0.4	-0.7	-0.9	1.0	1.1	-0.7
Short access day 10 total locomotion	0.5	0.5	1.0	0.0	-0.5	-0.6	0.7	1.0	-1.0
Short access total locomotion	0.6	0.6	0.9	0.3	-0.9	-0.7	0.9	0.9	-0.7
One hour access (0.3 mA shock)	1.9	2.2	3.0	-1.2	1.5	1.7	-1.7	-1.6	1.2
Compulsive drug intake	0.5	0.5	0.7	-0.8	0.8	0.7	-0.6	-0.7	0.7
One hour access (shock baseline)	0.4	0.5	1.0	-0.1	0.5	0.7	-0.8	-1.0	0.8
Social response proportion	0.2	0.2	0.5	0.4	-0.6	-0.6	0.7	0.1	-0.2
Social responses	0.1	0.1	0.3	0.4	-0.1	-0.5	0.6	0.1	0.2
Social time	0.0	0.1	0.2	0.1	-0.1	-0.3	0.4	-0.0	0.2
Soleus weight	1.4	4.1	5.1	-1.9	2.3	2.2	-2.2	-1.9	1.6
Bone: stiffness	1.1	1.7	5.1	-2.2	1.2	1.3	-0.7	-0.9	1.0
Tibialis anterior weight	0.2	0.5	1.2	0.1	0.3	0.5	-0.7	-1.1	1.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	-0.2	0.4	0.4	-0.4	-0.4	0.5
Time to tail flick, vehicle, after self-admin	1.8	1.9	2.7	1.5	-1.5	-1.6	1.6	1.0	-0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.3	-0.1	0.5	-0.3	-0.2	-0.5
Time to tail flick, test, after self-admin	0.5	0.5	0.7	0.6	-0.7	-0.8	0.8	0.6	-0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.7	0.9	-0.6	-0.5	0.4	-0.1	0.1
Delta time to tail flick, test, before/after SA	1.1	0.9	1.6	0.4	-0.7	-1.1	1.2	1.3	-0.8
Tibia length	7.1	20.0	45.9	-6.8	5.3	5.1	-3.8	-2.1	0.9
Ambulatory time before self-admin	1.4	1.4	3.1	-1.8	1.7	1.1	-1.1	-0.2	0.2
Ambulatory time after self-admin	0.4	0.4	0.7	-0.2	0.8	0.5	-0.8	-0.7	0.6
Bone: tissue strength	1.9	1.9	2.1	-1.5	1.4	1.3	-1.1	-1.4	1.5
Total heroin consumption	0.6	0.7	1.9	-0.7	-0.0	-0.7	0.9	1.4	-0.8
Bone: trabecular number	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	-0.2	0.2
Bone: trabecular spacing	1.4	1.8	5.2	-0.1	0.7	0.7	-0.9	-1.9	2.3
Bone: trabecular thickness	0.6	0.7	2.2	-1.0	0.4	0.4	-0.1	0.9	-1.5
Bone: trabecular tissue density	0.7	1.1	1.5	1.2	-1.2	-1.1	1.1	0.9	-0.6
Water consumed over 24 hours	0.4	0.4	1.2	0.4	-0.3	-0.4	0.4	0.9	-1.1
Number of responses in last shaping day	0.7	0.8	1.3	-1.1	1.1	0.7	-0.6	-0.8	0.8