Hub : Genes

Skap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Skap1 0.16 0.13 4.2e-03 0.09 0.06 0.05 0.06 4.5e-03 1.6e-02 2.5e-02 1.2e-02
2 Brain gene expression Skap1 0.06 0.04 1.1e-07 0.07 0.07 0.07 0.07 2.0e-07 3.4e-07 5.6e-07 3.4e-07
3 PL gene expression Skap1 0.21 0.12 0.0e+00 0.23 0.22 0.22 0.22 8.5e-25 4.3e-24 3.9e-24 2.8e-24
4 PL alternative TSS XM_039085326.1 0.04 0.03 1.6e-05 0.02 0.04 0.02 0.02 6.1e-03 9.7e-05 1.7e-03 2.3e-03
5 BLA alternative TSS XM_039085327.1 0.06 0.05 2.7e-03 0.02 0.02 0.01 0.02 2.1e-02 3.9e-02 1.3e-01 4.1e-02
6 PL alternative TSS XM_039085326.1 0.03 0.02 4.1e-04 0.02 0.02 0.02 0.02 5.8e-03 1.8e-03 6.3e-03 4.5e-03
7 NAcc intron excision ratio chr10_81452618_81493274 0.02 0.02 7.1e-03 0.01 0.01 -0 0.01 6.2e-03 1.1e-02 4.9e-01 1.3e-02
8 IL gene expression Skap1 0.26 0.18 5.1e-04 0.05 0.1 0.06 0.06 2.0e-02 2.1e-03 1.8e-02 1.7e-02
9 NAcc intron excision ratio chr10_81487270_81493274 0.02 0.02 5.7e-03 0.01 0.01 0.01 0.01 9.8e-03 1.7e-02 1.0e-02 2.6e-02
10 BLA gene expression Skap1 0.23 0.12 8.2e-15 0.21 0.24 0.24 0.24 1.7e-11 2.2e-13 2.5e-13 5.9e-13
11 NAcc gene expression Skap1 0.07 0.05 5.2e-11 0.08 0.09 0.09 0.09 2.3e-09 6.0e-11 1.8e-10 1.7e-10
12 BLA alternative TSS XM_039085326.1 0.09 0.07 2.0e-04 0.05 0.05 0.04 0.05 1.5e-03 7.2e-04 4.2e-03 1.1e-03
13 BLA alternative TSS XM_039085326.1 0.12 0.1 7.6e-05 0.06 0.06 0.05 0.06 2.2e-04 4.0e-04 1.1e-03 6.0e-04
14 BLA alternative TSS NM_173311.2 0.05 0.05 2.9e-03 0.03 0.01 0 0.01 1.2e-02 9.2e-02 2.8e-01 8.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.52.52.9-1.5-1.5-1.5-1.6-1.5-1.61.61.6-1.51.61.5-1.61.7-1.7
Area under the delay curve0.20.20.50.00.50.40.40.70.4-0.7-0.40.7-0.4-0.40.4-0.40.4
BMI with tail16.854.369.3-8.1-8.3-8.1-7.6-8.0-7.57.07.6-7.07.47.2-6.96.1-6.1
BMI without tail1.42.93.2-1.7-1.7-1.7-1.7-1.7-1.71.61.7-1.51.71.7-1.71.8-1.8
Body weight0.83.24.8-2.2-2.0-2.1-1.9-2.0-1.81.61.9-1.61.81.7-1.61.2-1.2
Weight adjusted by age0.60.71.50.50.70.50.70.40.7-1.2-0.71.1-0.8-0.80.9-1.11.1
Bone surface0.40.71.0-0.8-0.9-0.9-0.8-1.0-0.80.70.8-0.70.80.8-0.80.9-0.9
Bone volume1.22.12.6-1.3-1.4-1.5-1.4-1.6-1.51.31.5-1.21.51.4-1.41.5-1.5
Breakpoint value in progressive ratio session4.24.65.32.12.01.92.21.72.2-2.2-2.22.1-2.2-2.32.3-2.22.2
Number of licking bursts0.20.30.80.90.80.60.60.30.5-0.4-0.50.4-0.5-0.50.4-0.30.3
Context. condit. distance diff. score0.60.71.2-1.1-1.1-1.0-0.8-1.0-0.80.60.8-0.60.70.7-0.60.7-0.7
Locomotion velocity, session 10.20.20.50.2-0.0-0.1-0.3-0.2-0.40.60.4-0.50.40.5-0.60.7-0.7
Locomotion distance, session 13.44.36.22.42.42.52.12.12.1-1.8-2.12.0-2.0-2.01.8-1.91.9
Locomotion velocity, session 21.21.41.91.31.21.41.21.31.2-1.3-1.21.4-1.1-1.11.0-0.90.9
Locomotion distance, session 24.36.08.93.03.02.82.62.42.5-2.0-2.52.1-2.4-2.32.2-2.12.1
Locomotion velocity, session 30.10.10.3-0.6-0.3-0.1-0.2-0.2-0.2-0.20.20.20.10.1-0.0-0.30.3
Locomotion distance, session 32.72.93.61.21.71.71.61.61.7-1.9-1.71.9-1.7-1.71.8-1.91.9
Stereotopy head waving bouts, day 34.65.46.5-2.1-2.3-2.4-2.3-2.3-2.32.52.3-2.62.32.3-2.32.3-2.3
Stereotopy head waving duration, day 33.44.04.7-1.8-2.1-2.0-2.0-1.9-2.02.12.0-2.22.02.0-2.01.9-1.9
Locomotion velocity, session 71.11.31.80.91.21.01.10.91.1-1.1-1.11.1-1.1-1.21.2-1.31.3
Locomotion distance, session 75.36.77.72.52.82.72.72.62.7-2.4-2.62.4-2.7-2.72.6-2.42.4
Stereotopy head waving bouts, day 70.40.50.6-0.4-0.6-0.8-0.7-0.7-0.70.60.7-0.60.70.7-0.80.7-0.7
Stereotopy head waving duration, day 70.20.20.3-0.3-0.4-0.5-0.5-0.6-0.50.40.5-0.40.50.5-0.50.3-0.3
Locomotion velocity, session 80.30.31.1-0.4-0.7-0.9-0.5-1.1-0.50.60.5-0.60.50.5-0.40.3-0.3
Locomotion distance, session 80.60.91.30.91.01.10.90.81.0-0.9-1.01.0-0.9-0.90.9-0.80.8
Degree of sensitization distance0.00.00.00.20.1-0.10.10.00.10.1-0.1-0.1-0.1-0.10.1-0.10.1
Degree of sensitization stereotypy0.10.20.50.70.50.20.40.20.4-0.4-0.40.5-0.4-0.30.3-0.40.4
Conditioned locomotion1.51.82.3-1.5-1.5-1.4-1.4-1.3-1.31.41.3-1.31.31.3-1.21.2-1.2
Cocaine response after cond. corrected6.47.28.2-2.6-2.8-2.7-2.7-2.5-2.72.62.7-2.62.72.7-2.62.9-2.9
Cocaine response after cond. not corrected3.63.94.8-2.0-2.1-2.0-2.0-1.7-1.91.91.9-2.02.02.0-1.92.2-2.2
Cocaine response before conditioning2.83.44.31.81.92.01.92.11.9-1.7-1.91.7-1.9-1.81.8-1.81.8
Saline control response0.10.10.6-0.8-0.7-0.3-0.0-0.1-0.0-0.10.00.1-0.1-0.20.3-0.60.6
Bone: connectivity density0.10.20.6-0.8-0.5-0.4-0.5-0.4-0.40.40.4-0.40.40.4-0.40.5-0.5
Bone: cortical apparent density5.87.69.02.62.72.42.92.32.9-2.6-2.82.6-2.9-3.03.0-2.92.9
Bone: cortical area0.20.31.0-1.0-1.0-0.6-0.6-0.5-0.5-0.10.50.20.50.4-0.30.2-0.2
Bone: cortical porosity0.40.40.6-0.8-0.8-0.5-0.7-0.4-0.70.50.7-0.40.70.8-0.70.7-0.7
Bone: cortical porosity0.30.30.5-0.7-0.7-0.4-0.6-0.3-0.60.50.6-0.30.60.7-0.60.6-0.6
Bone: cortical thickness0.10.20.4-0.6-0.6-0.30.0-0.10.1-0.5-0.10.6-0.2-0.30.4-0.60.6
Bone: cortical thickness1.21.42.70.81.11.41.11.61.2-1.2-1.21.2-1.2-1.21.2-1.01.0
Bone: cortical tissue density6.28.29.62.82.92.53.02.43.0-2.7-3.02.7-3.0-3.13.1-2.92.9
Condit. Reinf. active minus inactive responses0.30.40.90.90.70.70.70.80.6-0.5-0.60.5-0.6-0.60.5-0.30.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.5-0.1-0.30.1-0.30.30.3-0.30.30.3-0.40.4-0.4
Condit. Reinf. active responses0.40.41.11.11.00.80.70.70.7-0.3-0.70.4-0.6-0.60.5-0.20.2
Condit. Reinf. inactive responses0.60.72.11.11.50.90.90.60.9-0.5-0.90.6-0.9-0.80.7-0.50.5
Incentive salience index mean0.91.02.11.41.31.21.11.21.0-0.9-1.00.9-1.0-0.90.8-0.60.6
Condit. Reinf. lever presses1.62.13.31.81.81.61.51.41.4-1.4-1.41.3-1.4-1.31.2-1.21.2
Condit. Reinf. active minus inactive responses0.00.10.10.10.20.1-0.10.1-0.10.30.1-0.20.20.2-0.30.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.50.20.1-0.1-0.3-0.2-0.30.70.3-0.60.40.5-0.60.7-0.7
Condit. Reinf. active responses0.00.00.20.00.30.40.10.30.1-0.1-0.10.2-0.1-0.0-0.00.1-0.1
Condit. Reinf. inactive responses0.10.20.4-0.10.10.40.30.40.3-0.6-0.30.6-0.4-0.40.5-0.60.6
Condit. Reinf. lever presses0.81.12.10.81.01.51.01.31.0-1.0-1.01.1-1.0-1.01.0-1.01.0
Condit. Reinf. lever reinforcers received0.10.10.30.10.40.50.20.40.3-0.3-0.20.4-0.2-0.20.2-0.20.2
Conditioned reinforcement - actives0.40.41.3-0.00.0-0.1-0.5-0.2-0.50.60.6-0.70.70.8-0.91.1-1.1
Conditioned reinforcement - inactives0.40.41.4-0.40.00.40.30.10.3-1.2-0.30.8-0.4-0.50.6-1.01.0
Conditioned locomotion1.92.35.0-0.6-0.6-0.6-1.4-0.7-1.51.41.5-1.61.61.8-2.02.2-2.2
Patch foraging indifference point 0 sec0.81.21.6-1.2-1.0-1.0-1.2-0.8-1.20.61.1-0.51.21.3-1.21.3-1.3
Patch foraging indifference point AUC0.10.20.40.10.30.50.40.60.4-0.4-0.40.4-0.4-0.40.4-0.30.3
Delay disc. indifference point, 0s delay0.50.61.4-0.30.30.30.50.60.6-0.9-0.61.0-0.6-0.70.8-1.21.2
Delay disc. indifference point, 16s delay0.50.51.0-1.0-0.8-0.6-0.7-0.4-0.70.60.7-0.60.70.7-0.60.7-0.7
Delay disc. indifference point, 2s delay0.20.20.60.10.50.20.30.40.3-0.5-0.30.4-0.3-0.30.4-0.70.7
Delay disc. indifference point, 24s delay0.70.71.10.90.91.10.81.00.8-1.0-0.80.9-0.8-0.80.7-0.40.4
Delay disc. indifference point, 4s delay2.93.05.01.01.71.51.61.71.7-2.0-1.72.2-1.7-1.71.8-1.91.9
Delay disc. indifference point, 8s delay0.20.20.40.20.60.50.40.70.4-0.6-0.40.6-0.4-0.40.4-0.10.1
Indifference point function ln k0.10.10.30.40.30.10.10.30.2-0.5-0.10.6-0.1-0.00.00.3-0.3
Indifference point function log k0.10.10.30.40.30.10.10.30.2-0.5-0.10.6-0.1-0.00.00.3-0.3
Patch foraging total patch changes 0 sec0.91.41.9-1.4-1.2-1.2-1.3-0.9-1.30.71.2-0.61.31.3-1.31.3-1.3
Patch foraging total patch changes 12 sec0.10.20.5-0.6-0.2-0.1-0.30.1-0.30.00.3-0.00.40.4-0.40.7-0.7
Patch foraging total patch changes 18 sec1.62.03.6-1.9-1.6-1.1-1.5-1.0-1.51.31.5-1.21.51.5-1.51.3-1.3
Patch foraging total patch changes 24 sec1.01.31.8-1.2-0.8-1.0-1.2-0.8-1.20.91.1-0.81.21.3-1.31.3-1.3
Patch foraging total patch changes 6 sec0.81.11.7-1.2-1.0-0.8-1.2-0.7-1.10.71.1-0.61.11.2-1.11.3-1.3
Patch foraging time to switch 0 sec0.00.10.20.20.30.20.0-0.1-0.00.40.0-0.20.10.1-0.20.3-0.3
Patch foraging water rate 0 sec1.01.72.7-1.7-1.6-1.4-1.4-1.2-1.41.01.4-1.01.31.3-1.21.0-1.0
Patch foraging water rate 12 sec0.10.20.6-0.7-0.8-0.4-0.3-0.5-0.2-0.40.20.50.10.10.1-0.40.4
Patch foraging water rate 18 sec0.30.41.2-0.1-0.30.10.30.10.3-1.0-0.30.8-0.4-0.50.6-1.11.1
Patch foraging water rate 24 sec1.01.42.7-1.2-1.7-1.4-1.3-1.2-1.20.91.2-1.01.21.2-1.10.7-0.7
Patch foraging water rate 6 sec0.00.00.20.00.10.10.00.10.1-0.1-0.1-0.1-0.1-0.10.1-0.40.4
Seeking ratio, delayed vs. immediate footshock0.91.02.5-1.6-1.4-1.2-1.0-1.1-1.00.91.0-0.60.90.8-0.70.8-0.8
Distance traveled before self-admin1.21.32.31.41.51.41.11.41.1-1.1-1.10.8-1.0-1.00.9-0.80.8
Distance traveled after self-admin0.60.71.8-0.6-0.1-0.3-0.8-0.3-0.70.50.8-0.70.91.0-1.01.3-1.3
Extensor digitorum longus weight0.41.53.1-1.8-1.8-1.7-1.3-1.6-1.20.51.3-0.31.21.1-0.90.6-0.6
Bone: elastic displacement0.10.10.2-0.20.1-0.1-0.3-0.1-0.30.50.3-0.40.30.4-0.40.4-0.4
Bone: elastic work0.00.00.1-0.30.10.2-0.10.1-0.1-0.00.10.10.10.1-0.10.2-0.2
Bone: endosteal estimation0.10.31.0-0.1-0.3-0.1-0.5-0.2-0.50.10.5-0.20.60.7-0.71.0-1.0
Bone: endosteal perimeter0.30.61.1-0.5-0.7-0.6-0.8-0.7-0.80.40.8-0.40.90.9-0.91.1-1.1
Epididymis fat weight0.10.20.9-0.9-0.6-0.5-0.4-0.4-0.4-0.10.5-0.00.40.3-0.2-0.10.1
Delta time in closed arm before/after self-admin0.10.10.4-0.4-0.5-0.6-0.1-0.5-0.1-0.60.10.50.00.00.1-0.10.1
Delta time in open arm before/after self-admin0.10.10.20.40.40.20.30.30.3-0.3-0.30.3-0.3-0.30.3-0.50.5
Diff in mean of infusions in LGA sessions0.80.91.71.30.90.91.10.81.0-0.8-1.00.8-1.0-1.11.0-0.90.9
Delay discount exponential model param0.30.30.7-0.2-0.6-0.5-0.5-0.8-0.50.80.5-0.80.50.5-0.50.5-0.5
Extinction: sum of active levers before priming1.11.12.00.91.01.11.01.11.0-1.4-1.01.4-1.0-1.01.0-0.80.8
Active lever presses in extinction session 60.10.10.20.10.10.1-0.1-0.0-0.10.40.1-0.30.20.2-0.20.5-0.5
Bone: final force0.20.30.6-0.7-0.8-0.3-0.6-0.5-0.60.20.6-0.20.60.6-0.60.6-0.6
Bone: final moment0.30.40.7-0.8-0.8-0.4-0.7-0.5-0.70.30.7-0.30.70.7-0.70.7-0.7
Food consumed during 24 hour testing period1.82.23.11.71.71.31.51.51.5-1.7-1.51.7-1.5-1.41.4-1.21.2
Glucose0.91.42.0-1.2-1.2-1.4-1.1-1.4-1.11.41.1-1.41.11.1-1.00.9-0.9
Heart weight1.72.43.3-1.7-1.8-1.8-1.6-1.6-1.61.51.6-1.41.61.5-1.51.2-1.2
Delay discount hyperbolic model param0.50.51.0-0.3-0.7-0.6-0.6-0.9-0.71.00.7-1.00.70.7-0.70.7-0.7
Intermittent access intake day 1-15 change1.71.72.9-0.8-0.5-1.0-1.3-1.0-1.31.71.2-1.71.41.4-1.51.4-1.4
Intermittent access intake escalation1.41.43.0-0.4-0.2-0.6-1.1-0.7-1.11.71.1-1.71.21.3-1.51.4-1.4
Intermittent access intake escalation 21.41.43.6-0.6-0.5-0.7-1.1-0.8-1.11.91.1-1.81.21.2-1.31.1-1.1
Intermitt. access day 1 inactive lever presses0.10.10.5-0.3-0.2-0.20.1-0.20.1-0.2-0.10.1-0.2-0.30.4-0.70.7
Intermitt. access day 15 inactive lever presses0.70.81.9-1.4-1.3-0.9-0.9-0.9-0.90.90.8-0.90.80.7-0.60.4-0.4
Intermitt. access escalation Index0.90.83.10.8-0.0-0.1-0.4-0.1-0.50.90.5-0.80.70.9-1.01.8-1.8
Intermittent access day 1 total infusions0.30.41.10.40.30.60.60.50.6-1.1-0.50.9-0.6-0.60.6-0.40.4
Intermittent access day 15 total infusions0.10.10.20.50.50.40.00.20.00.20.0-0.20.10.2-0.30.5-0.5
Intermittent access terminal intake (last 3 days)0.10.10.20.00.20.2-0.1-0.0-0.20.30.2-0.40.20.3-0.30.4-0.4
Intermittent access total infusions0.00.00.2-0.00.20.40.10.20.1-0.4-0.00.2-0.0-0.0-0.00.1-0.1
Intermittent access day 1 locomotion0.60.71.51.21.11.00.90.80.9-0.8-0.80.7-0.8-0.70.6-0.40.4
Intermittent access day 15 total locomotion0.10.10.30.30.30.1-0.00.1-0.10.30.1-0.40.20.2-0.40.5-0.5
Intermittent access total locomotion0.20.20.70.40.50.4-0.10.3-0.10.40.2-0.50.30.4-0.60.9-0.9
Intermittent access standard deviation1.51.63.5-1.1-0.7-0.6-1.2-0.8-1.21.91.2-1.91.31.3-1.41.2-1.2
Left kidney weight0.00.00.2-0.0-0.1-0.10.0-0.10.0-0.3-0.00.4-0.1-0.10.1-0.10.1
Right kidney weight0.31.01.4-1.0-1.1-1.2-1.1-1.0-1.10.61.0-0.61.11.1-1.00.9-0.9
Cocaine induced anxiety0.10.10.2-0.1-0.2-0.4-0.2-0.2-0.20.30.2-0.30.20.2-0.30.1-0.1
Post-drug Anxiety0.50.50.80.80.70.50.80.50.7-0.5-0.70.5-0.7-0.80.7-0.90.9
Baseline Anxiety0.00.00.1-0.0-0.10.00.0-0.30.00.3-0.0-0.2-0.0-0.10.1-0.30.3
Tail length14.744.558.97.27.77.36.87.26.8-6.6-6.86.6-6.6-6.46.2-5.45.4
Length with tail8.229.937.65.66.15.75.65.75.6-5.5-5.65.3-5.5-5.35.2-4.84.8
Length without tail0.10.20.60.00.2-0.10.3-0.00.3-0.6-0.30.5-0.4-0.40.5-0.80.8
Times rat made contact with spout0.20.20.90.90.60.40.50.40.5-0.4-0.40.4-0.4-0.40.3-0.10.1
Lifetime Intake0.10.10.50.30.50.60.30.40.3-0.7-0.30.5-0.3-0.20.2-0.10.1
Liver weight, left0.91.41.71.21.11.11.21.31.2-1.2-1.21.2-1.2-1.21.2-1.11.1
Liver weight, right0.71.21.70.50.81.01.11.01.1-0.9-1.10.9-1.1-1.21.3-1.31.3
Locomotor activity0.30.50.8-0.7-0.4-0.6-0.7-0.6-0.80.60.8-0.80.80.8-0.90.9-0.9
Locomotor testing distance0.71.11.5-0.9-0.6-1.0-1.1-0.9-1.10.91.1-1.01.11.2-1.21.2-1.2
Locomotor testing rearing0.00.00.1-0.40.0-0.2-0.2-0.1-0.20.30.2-0.10.20.2-0.2-0.00.0
Locomotion in novel chamber0.30.30.80.2-0.1-0.10.5-0.10.5-0.7-0.40.5-0.6-0.70.8-0.90.9
Locomotion in novel chamber post-restriction2.02.43.6-1.6-1.9-1.5-1.6-1.6-1.61.11.6-1.31.61.6-1.51.5-1.5
Fecal boli incidents, locomotor time 13.33.65.6-1.5-1.7-2.0-1.8-2.1-1.92.21.8-2.41.81.8-1.81.8-1.8
Change in fecal boli incidents, locomotor task2.12.03.11.11.21.21.41.21.4-1.8-1.41.6-1.4-1.41.5-1.51.5
Time >=10cm from walls, locomotor time 10.20.20.70.0-0.00.10.30.40.3-0.6-0.30.8-0.4-0.40.5-0.20.2
Bouts of movement, locomotor time 10.10.10.3-0.6-0.2-0.3-0.3-0.4-0.30.50.3-0.30.30.2-0.20.4-0.4
Total resting periods, locomotor time 10.40.40.8-0.9-0.6-0.7-0.6-0.7-0.60.80.6-0.60.50.5-0.40.6-0.6
Rest time, locomotor task time 10.20.20.6-0.3-0.1-0.2-0.4-0.5-0.40.70.4-0.80.40.4-0.50.6-0.6
Distance moved, locomotor task time 11.41.52.51.61.21.21.31.31.3-1.2-1.31.0-1.3-1.31.2-1.01.0
Vertical activity count, locomotor time 10.30.30.80.60.30.50.60.60.6-0.9-0.50.9-0.6-0.50.6-0.40.4
Time >=10cm from walls, locomotor time 20.50.51.00.50.50.50.70.60.7-1.0-0.70.9-0.7-0.70.8-0.70.7
Bouts of movement, locomotor time 20.10.10.2-0.3-0.3-0.3-0.3-0.4-0.30.50.3-0.40.30.3-0.30.3-0.3
Total resting periods, locomotor time 20.20.20.3-0.4-0.3-0.4-0.4-0.5-0.40.50.4-0.50.40.4-0.40.3-0.3
Rest time, locomotor task time 20.80.91.21.00.80.61.00.51.0-0.9-1.01.0-1.0-1.11.1-1.11.1
Distance moved, locomotor task time 20.10.20.30.40.60.40.40.50.4-0.6-0.40.3-0.3-0.30.3-0.20.2
Vertical activity count, locomotor time 20.00.00.20.00.20.1-0.00.1-0.0-0.30.10.10.10.2-0.20.4-0.4
Light reinforcement 10.20.30.8-0.1-0.0-0.2-0.4-0.2-0.40.90.4-0.90.50.6-0.70.8-0.8
Light reinforcement 20.10.20.70.90.70.50.30.40.30.0-0.30.0-0.2-0.10.00.3-0.3
Bone: marrow area0.10.20.8-0.0-0.20.0-0.4-0.1-0.4-0.00.4-0.00.50.5-0.60.9-0.9
Bone: maximum diameter0.30.60.9-0.6-0.9-0.7-0.8-0.6-0.80.20.8-0.20.80.9-0.91.0-1.0
Bone: maximum force0.61.01.7-1.2-1.3-0.8-1.1-0.9-1.10.51.1-0.41.11.1-1.01.2-1.2
Bone: maximum moment0.71.11.7-1.2-1.3-0.8-1.1-0.9-1.10.61.1-0.51.11.1-1.11.2-1.2
Mean time between licks in bursts0.50.72.0-1.4-1.4-0.8-0.9-1.0-0.80.50.8-0.50.70.7-0.50.4-0.4
Mean num. licks in bursts0.00.00.1-0.1-0.2-0.10.00.20.0-0.2-0.00.2-0.1-0.10.2-0.20.2
Cd content in liver0.30.30.70.20.00.00.50.10.5-0.5-0.50.5-0.6-0.70.7-0.80.8
Co content in liver0.10.10.6-0.2-0.3-0.4-0.2-0.4-0.20.70.2-0.80.20.1-0.20.2-0.2
Cu content in liver4.15.010.03.22.92.22.42.22.3-2.0-2.32.1-2.2-2.11.9-1.51.5
Fe content in liver1.41.71.91.41.21.31.41.11.3-1.2-1.31.3-1.3-1.31.3-1.31.3
K content in liver0.10.10.40.60.40.10.1-0.10.00.5-0.0-0.40.00.1-0.20.3-0.3
Mg content in liver1.01.01.81.41.30.91.10.71.1-0.8-1.00.8-1.0-1.00.9-0.90.9
Mn content in liver3.64.15.82.42.32.22.12.22.1-1.7-2.11.7-2.0-2.01.9-1.71.7
Na content in liver0.30.30.70.50.60.1-0.2-0.1-0.30.60.3-0.60.40.5-0.70.8-0.8
Rb content in liver0.00.10.10.30.3-0.20.2-0.20.20.0-0.2-0.1-0.2-0.30.2-0.40.4
Se content in liver0.30.41.0-0.4-0.6-0.7-0.5-0.8-0.51.00.5-0.90.50.4-0.50.3-0.3
Sr content in liver1.81.62.60.90.91.31.21.41.2-1.6-1.21.6-1.2-1.21.3-1.31.3
Zn content in liver0.00.00.1-0.00.0-0.3-0.1-0.4-0.20.30.2-0.30.20.1-0.2-0.00.0
Bone: minimum diameter0.00.10.2-0.4-0.5-0.0-0.3-0.1-0.3-0.10.30.20.30.3-0.30.4-0.4
Time in familiar zone, hab. session 10.30.30.50.10.30.50.50.30.5-0.6-0.50.5-0.6-0.60.7-0.60.6
Time in novel zone, hab. session 12.82.73.3-1.2-1.3-1.7-1.6-1.6-1.71.81.6-1.71.71.7-1.81.7-1.7
Total zone transitions, hab. session 16.48.99.83.02.93.03.12.73.1-2.7-3.02.9-3.1-3.13.0-3.13.1
Total locomotion distance, hab. session 13.14.45.22.32.32.22.22.02.2-1.8-2.11.9-2.1-2.12.0-2.02.0
Locomotion velocity, hab. session 14.05.76.62.62.42.52.52.32.4-2.1-2.42.2-2.4-2.42.3-2.32.3
Time in familiar zone, hab. session 20.80.81.2-1.1-1.1-1.1-0.9-1.0-0.91.00.9-1.10.80.8-0.70.4-0.4
Time in novel zone, hab. session 20.10.10.20.30.30.40.30.30.3-0.4-0.30.5-0.3-0.30.2-0.10.1
Total zone transitions, hab. session 22.93.86.02.52.12.32.02.02.0-1.8-2.01.9-1.9-1.81.7-1.51.5
Total locomotion distance, hab. session 20.20.31.01.00.90.80.60.60.5-0.2-0.50.3-0.5-0.40.3-0.10.1
Locomotion velocity, hab. session 20.40.51.31.11.11.00.70.80.7-0.3-0.70.4-0.6-0.50.4-0.20.2
Novel to familiar place preference ratio0.50.50.80.30.40.50.70.50.7-0.9-0.70.9-0.8-0.80.9-0.70.7
Novelty place preference0.50.50.90.30.40.60.70.60.8-0.9-0.80.9-0.8-0.91.0-0.70.7
Time in novel zone, NPP test0.40.40.70.20.20.40.60.40.6-0.7-0.60.7-0.7-0.70.8-0.60.6
Total zone transitions, NPP test4.97.09.43.03.13.02.72.62.6-2.4-2.62.5-2.6-2.52.3-2.52.5
Total locomotion distance, NPP test1.31.72.81.51.71.51.31.31.3-1.1-1.31.2-1.2-1.21.1-1.31.3
Locomotion velocity, NPP test1.92.73.81.81.92.01.61.71.6-1.4-1.61.5-1.6-1.51.4-1.61.6
Intraocular pressure1.62.23.51.31.41.71.51.91.5-1.7-1.51.7-1.5-1.41.4-0.90.9
Delta distance traveled before/after self-admin2.52.73.6-1.7-1.5-1.5-1.7-1.6-1.71.31.7-1.31.71.8-1.71.9-1.9
Delta ambulatory time before/after self-admin3.23.54.2-1.8-1.9-1.9-1.9-2.0-1.91.61.9-1.51.91.9-1.82.0-2.0
Parametrial fat weight0.10.10.40.40.20.40.20.30.2-0.6-0.10.5-0.1-0.00.00.4-0.4
Pavlov. Cond. lever latency1.51.92.6-1.2-1.4-1.3-1.3-1.1-1.31.61.3-1.61.31.3-1.31.6-1.6
Pavlov. Cond. magazine entry latency0.10.10.30.30.40.50.30.60.3-0.5-0.30.4-0.3-0.20.20.0-0.0
Pavlov. Cond. change in total contacts2.93.13.71.81.91.81.81.81.8-1.9-1.81.8-1.8-1.71.7-1.51.5
Pavlov. Cond. index score0.70.91.40.91.01.00.91.00.9-1.2-0.91.2-0.9-0.90.8-0.80.8
Pavlov. Cond. latency score0.81.01.51.01.11.01.01.01.0-1.2-0.91.2-0.9-0.90.9-0.90.9
Pavlov. Cond. lever contacts2.42.83.91.61.81.71.61.51.6-2.0-1.62.0-1.6-1.61.5-1.61.6
Pavlov. Cond. magazine entry number0.40.50.9-0.6-0.7-0.7-0.7-0.8-0.60.90.6-0.90.60.6-0.60.4-0.4
Pavlov. Cond. intertrial magazine entries0.40.50.80.90.80.70.80.50.8-0.4-0.80.4-0.8-0.80.8-0.70.7
Pavlov. Cond. lever-magazine prob. diff.0.70.91.50.80.91.00.91.00.9-1.2-0.91.2-0.8-0.80.8-0.80.8
Pavlov. Cond. response bias0.70.91.50.81.11.00.91.10.9-1.2-0.91.2-0.9-0.80.8-0.80.8
Pavlov. Cond. lever latency0.81.11.81.21.00.81.10.81.0-1.3-1.01.3-1.1-1.01.0-0.80.8
Pavlov. Cond. magazine entry latency0.50.60.91.00.90.80.80.80.8-0.6-0.80.5-0.8-0.80.7-0.70.7
Pavlov. Cond. change in total contacts0.10.20.3-0.6-0.20.0-0.50.2-0.40.50.4-0.60.50.5-0.50.5-0.5
Pavlov. Cond. index score0.20.30.6-0.4-0.4-0.2-0.5-0.2-0.50.70.4-0.80.50.6-0.60.6-0.6
Pavlov. Cond. latency score0.10.10.3-0.1-0.10.0-0.20.1-0.20.50.2-0.50.30.3-0.30.4-0.4
Pavlov. Cond. lever contacts0.60.81.4-1.0-0.9-0.6-0.9-0.7-0.91.10.9-1.20.90.9-0.90.7-0.7
Pavlov. Cond. magazine entry number0.00.00.1-0.1-0.1-0.2-0.0-0.2-0.0-0.20.00.30.0-0.00.0-0.10.1
Pavlov. Cond. intertrial magazine entries1.62.12.61.31.21.31.51.21.5-1.5-1.41.5-1.5-1.51.5-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.30.30.7-0.4-0.4-0.3-0.6-0.2-0.60.80.5-0.80.60.6-0.60.7-0.7
Pavlov. Cond. response bias0.50.71.2-0.9-0.7-0.5-0.9-0.6-0.81.10.8-1.10.80.9-0.80.7-0.7
Time in closed arm before self-admin2.12.35.2-2.3-1.7-1.5-1.7-1.7-1.61.41.6-1.61.51.4-1.40.7-0.7
Time in closed arm after self-admin2.22.25.3-2.3-2.1-2.0-1.6-2.1-1.50.51.6-0.91.41.3-1.10.5-0.5
Time in open arm before self-admin0.40.41.40.70.40.40.60.60.6-1.2-0.51.2-0.6-0.50.5-0.20.2
Time in open arm after self-admin0.70.71.51.00.90.70.80.80.8-1.2-0.81.2-0.8-0.70.8-0.60.6
Bone: periosteal estimation0.30.71.0-0.9-1.0-0.6-0.9-0.7-0.90.20.9-0.20.90.9-0.91.0-1.0
Bone: periosteal perimeter0.61.01.8-1.3-1.4-1.1-1.1-1.1-1.10.51.1-0.51.01.0-0.90.8-0.8
Bone: post-yield work0.40.51.1-0.9-1.1-0.7-0.7-0.8-0.70.50.7-0.50.60.6-0.50.7-0.7
Progressive ratio test 1 active lever presses0.50.51.40.90.70.70.70.70.7-1.2-0.61.0-0.6-0.50.5-0.10.1
Progressive ratio test 1 breakpoint0.60.71.70.90.70.80.80.80.8-1.3-0.71.1-0.8-0.70.7-0.40.4
Progressive ratio test 1 inactive lever presses0.10.10.5-0.6-0.7-0.4-0.4-0.5-0.3-0.30.40.10.30.3-0.20.2-0.2
Progressive ratio test 2 active lever presses0.30.31.00.50.70.70.50.70.5-1.0-0.50.7-0.5-0.40.4-0.20.2
Progressive ratio test 2 breakpoint0.10.20.80.20.40.40.30.50.3-0.9-0.20.7-0.3-0.20.2-0.10.1
Progressive ratio test 2 inactive lever presses0.10.10.4-0.7-0.20.1-0.0-0.10.0-0.40.00.2-0.1-0.20.2-0.50.5
Incentive Sensitization - Responses0.00.00.2-0.5-0.1-0.2-0.2-0.1-0.2-0.30.2-0.00.20.2-0.20.1-0.1
Incentive Sensitization - Breakpoint0.10.10.4-0.6-0.2-0.4-0.4-0.3-0.4-0.00.4-0.20.40.4-0.40.3-0.3
Sum of active levers in priming session hrs 5-65.14.96.82.62.32.42.32.32.3-1.9-2.32.1-2.2-2.22.1-1.91.9
Progressive ratio0.20.21.0-0.5-0.3-0.5-0.1-0.6-0.10.30.1-0.60.0-0.20.2-1.01.0
Food seeking constrained by brief footshock0.30.41.3-0.0-0.2-0.2-0.4-0.2-0.51.00.4-0.80.50.6-0.71.1-1.1
Seeking ratio, punishment vs. effort0.40.51.70.90.60.80.40.90.3-0.4-0.30.7-0.20.0-0.11.3-1.3
Retroperitoneal fat weight0.31.01.8-0.9-0.7-0.5-1.0-0.7-1.01.31.0-1.41.11.1-1.11.0-1.0
Reaction time number correct0.30.42.1-1.4-1.3-0.6-0.6-0.4-0.5-0.20.40.20.40.2-0.0-0.60.6
Reaction time mean minus median1.41.84.02.01.51.81.41.71.4-1.2-1.41.2-1.3-1.11.0-0.50.5
Reaction time mean minus median AUC1.72.24.72.21.61.91.61.91.5-1.3-1.51.4-1.4-1.31.2-0.60.6
Reaction time num false alarms0.50.71.21.11.10.80.81.00.8-1.1-0.80.9-0.8-0.70.6-0.70.7
Reaction time num false alarms AUC0.70.91.41.21.21.00.91.10.9-1.1-0.91.0-0.9-0.80.7-0.80.8
Reaction time trials correct on left0.30.42.1-1.4-1.3-0.6-0.6-0.4-0.5-0.20.40.20.40.2-0.0-0.60.6
Reaction time trials on left0.30.41.9-1.4-1.2-0.6-0.5-0.3-0.4-0.20.40.30.30.20.0-0.60.6
Reaction time mean0.40.52.11.40.91.00.71.00.6-0.5-0.60.5-0.5-0.40.30.5-0.5
Reaction time mean AUC0.50.72.51.60.91.10.81.10.7-0.7-0.70.7-0.6-0.40.40.4-0.4
Median of all reaction times0.10.20.60.80.30.50.20.60.10.0-0.1-0.1-0.10.1-0.20.8-0.8
Reaction time omissions0.50.72.11.41.11.30.81.20.8-0.6-0.80.6-0.7-0.50.40.3-0.3
Reaction time false alarm rate0.60.92.71.61.61.11.01.00.9-0.7-0.90.6-0.8-0.60.5-0.20.2
Reaction time premature initiation rate0.40.61.30.70.70.80.70.80.8-1.1-0.80.9-0.7-0.70.7-0.60.6
Reaction time premature initiations0.50.62.10.10.20.70.50.70.6-1.4-0.61.2-0.7-0.70.8-1.01.0
Std. dev. reaction times1.11.53.71.91.41.71.31.61.2-1.0-1.21.1-1.1-0.90.8-0.20.2
Reaction time trials completed0.30.41.9-1.4-1.2-0.6-0.5-0.3-0.4-0.20.40.30.30.20.0-0.60.6
Reaction time trials AUC0.30.41.9-1.4-1.2-0.6-0.5-0.3-0.4-0.30.40.40.30.10.0-0.70.7
Run reversals in cocaine runway, females0.30.30.60.40.60.70.50.70.5-0.8-0.50.6-0.4-0.40.4-0.20.2
Run reversals in cocaine runway, males1.41.32.4-1.3-1.5-1.6-1.2-1.6-1.20.41.2-0.61.11.1-1.00.7-0.7
Latency to leave start box in cocaine runway4.44.86.8-2.5-2.4-2.6-2.3-2.6-2.22.32.2-2.02.22.0-2.01.4-1.4
Latency to leave start box in cocaine runway, F6.57.19.3-3.0-2.9-3.0-2.8-3.0-2.82.72.8-2.42.72.6-2.52.0-2.0
Latency to leave start box in cocaine runway, M0.50.51.5-0.3-0.6-0.6-0.5-0.6-0.61.20.6-1.10.60.5-0.60.7-0.7
Std. dev. time between licks in bursts0.91.01.5-0.8-0.8-0.5-1.0-0.7-1.01.11.0-1.11.11.1-1.21.2-1.2
Total sessions with >9 infusions0.30.41.41.11.20.80.30.70.3-0.1-0.3-0.0-0.10.1-0.20.8-0.8
Short access day 1 total inactive lever presses2.42.74.90.50.81.51.41.41.5-2.2-1.51.8-1.5-1.71.8-2.22.2
Short access day 10 total inactive lever presses0.30.41.3-1.0-0.7-0.30.0-0.20.1-0.2-0.10.3-0.2-0.40.6-1.11.1
Short access day 1 total infusions0.20.20.60.60.60.70.40.80.4-0.6-0.40.3-0.4-0.30.3-0.20.2
Short access day 10 total infusions0.10.10.4-0.3-0.20.0-0.3-0.2-0.30.30.3-0.40.30.4-0.40.6-0.6
Short access total infusions0.00.00.10.10.20.10.0-0.0-0.0-0.40.00.10.00.0-0.10.0-0.0
Short access day 1 locomotion0.30.41.20.00.2-0.1-0.40.1-0.51.00.4-1.10.50.6-0.80.8-0.8
Short access day 10 total locomotion0.20.30.70.80.80.40.10.50.00.8-0.0-0.70.10.2-0.40.5-0.5
Short access total locomotion0.40.41.20.20.2-0.1-0.3-0.2-0.41.10.4-1.10.50.6-0.80.7-0.7
One hour access (0.3 mA shock)0.70.81.80.60.90.80.80.80.8-1.3-0.81.1-0.8-0.80.9-0.80.8
Compulsive drug intake8.08.010.32.82.72.62.92.62.9-3.2-2.93.2-2.9-2.92.9-2.62.6
One hour access (shock baseline)2.22.53.3-1.5-1.3-1.3-1.6-1.4-1.61.71.6-1.81.71.7-1.71.6-1.6
Social response proportion1.51.63.21.81.71.61.41.61.3-0.9-1.30.9-1.2-1.21.1-0.60.6
Social responses0.10.10.30.10.50.50.20.50.2-0.2-0.2-0.0-0.2-0.20.20.1-0.1
Social time0.00.00.1-0.2-0.4-0.0-0.1-0.1-0.10.10.1-0.10.00.00.0-0.00.0
Soleus weight1.44.15.1-2.3-2.2-2.1-2.1-2.2-2.12.12.1-2.12.02.0-1.91.6-1.6
Bone: stiffness0.10.10.4-0.5-0.6-0.1-0.3-0.2-0.3-0.20.30.20.30.3-0.30.4-0.4
Tibialis anterior weight0.20.82.00.60.60.70.70.70.8-1.3-0.81.4-0.8-0.80.9-0.80.8
Time to tail flick, vehicle, before self-admin1.61.62.21.21.01.11.41.01.4-1.3-1.41.3-1.4-1.51.5-1.21.2
Time to tail flick, vehicle, after self-admin0.40.41.1-1.0-0.7-0.5-0.7-0.5-0.60.90.6-0.80.60.5-0.50.3-0.3
Time to tail flick, test, before self-admin0.20.20.6-0.7-0.8-0.7-0.5-0.7-0.50.40.4-0.40.40.3-0.30.1-0.1
Time to tail flick, test, after self-admin0.20.20.4-0.6-0.4-0.5-0.4-0.4-0.40.30.4-0.30.40.4-0.30.6-0.6
Delta time to tail flick, vehicle, before/after SA2.22.13.4-1.9-1.4-1.4-1.6-1.4-1.51.61.5-1.61.51.5-1.41.1-1.1
Delta time to tail flick, test, before/after SA0.40.30.70.80.80.80.60.80.6-0.5-0.60.5-0.5-0.50.5-0.20.2
Tibia length0.61.62.4-1.5-1.3-1.4-1.3-1.5-1.31.21.3-1.21.21.2-1.11.1-1.1
Ambulatory time before self-admin0.80.81.41.01.21.10.81.20.8-1.2-0.80.8-0.8-0.70.6-0.60.6
Ambulatory time after self-admin1.01.22.6-0.9-0.4-0.5-1.1-0.6-1.00.71.1-0.91.11.3-1.31.6-1.6
Bone: tissue strength0.50.51.4-1.2-1.0-0.6-0.7-0.8-0.70.30.7-0.20.60.6-0.50.5-0.5
Total heroin consumption1.31.52.20.80.91.01.20.91.2-1.3-1.21.5-1.3-1.41.4-1.31.3
Bone: trabecular number0.40.61.1-0.5-0.4-0.6-0.7-0.8-0.71.00.7-0.90.80.8-0.91.0-1.0
Bone: trabecular spacing0.00.00.10.0-0.2-0.1-0.0-0.0-0.0-0.20.00.10.00.00.0-0.30.3
Bone: trabecular thickness2.02.43.5-1.9-1.7-1.5-1.7-1.6-1.61.11.6-1.11.61.6-1.51.5-1.5
Bone: trabecular tissue density0.10.10.30.30.40.30.30.30.3-0.4-0.30.5-0.3-0.30.3-0.50.5
Water consumed over 24 hours0.10.20.30.40.40.10.40.30.4-0.5-0.40.5-0.4-0.40.5-0.50.5
Number of responses in last shaping day0.80.82.3-1.5-1.5-1.5-0.9-1.2-0.9-0.00.9-0.00.70.6-0.40.2-0.2