Siva1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Siva1 0.17 0.12 2.2e-04 0.09 0.14 0.12 0.12 4.1e-03 3.5e-04 7.9e-04 6.9e-04
2 Adipose gene expression Siva1 0.06 0.04 6.5e-08 0.06 0.06 0.05 0.06 7.3e-07 5.5e-07 1.7e-06 3.0e-07
3 Liver gene expression Siva1 0.1 0.07 2.2e-12 0.1 0.09 0.1 0.1 9.5e-11 4.1e-10 4.9e-11 9.9e-11
4 BLA gene expression Siva1 0.04 0.03 6.2e-03 0.05 0.03 0.03 0.04 7.1e-04 1.1e-02 9.1e-03 3.6e-03
5 IL gene expression Siva1 0.28 0.21 5.0e-04 0.18 0.14 0.14 0.16 4.7e-05 2.8e-04 2.7e-04 9.6e-05
6 PL gene expression Siva1 0.07 0.05 2.4e-09 0.08 0.08 0.08 0.09 1.9e-09 3.0e-09 3.3e-09 1.2e-09
7 PL mRNA stability Siva1 0.03 0.02 1.5e-03 0.02 0.03 0.02 0.02 2.8e-03 7.8e-04 6.7e-03 1.3e-03
8 RMTg gene expression Siva1 0.15 0.11 2.9e-03 0.12 0.1 0.1 0.1 5.6e-04 1.3e-03 1.3e-03 1.1e-03
9 Brain gene expression Siva1 0.16 0.19 5.0e-09 0.1 0.09 0.08 0.09 8.2e-10 2.8e-08 3.2e-08 4.7e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.00.10.1-0.00.20.30.2-0.1-0.1-0.1-0.1
Area under the delay curve0.20.20.9-1.0-0.60.50.20.2-0.3-0.20.20.4
BMI with tail2.27.18.8-2.6-3.02.82.52.7-2.8-2.82.62.3
BMI without tail0.40.92.0-1.3-1.40.80.31.1-1.1-1.00.50.1
Body weight0.62.75.42.31.7-1.7-1.5-0.81.51.5-1.8-1.7
Weight adjusted by age0.20.30.50.50.6-0.5-0.2-0.10.70.7-0.70.2
Bone surface0.10.10.2-0.5-0.40.40.40.3-0.2-0.10.1-0.0
Bone volume0.00.10.2-0.4-0.30.20.20.2-0.1-0.0-0.2-0.3
Breakpoint value in progressive ratio session0.20.30.8-0.1-0.30.40.10.3-0.7-0.70.90.6
Number of licking bursts0.10.20.7-0.9-0.50.3-0.1-0.2-0.2-0.20.30.3
Context. condit. distance diff. score3.34.05.12.22.3-2.0-1.8-1.42.22.1-2.1-1.8
Locomotion velocity, session 10.10.20.20.50.4-0.4-0.4-0.40.40.4-0.3-0.3
Locomotion distance, session 10.60.71.0-0.6-0.80.80.90.8-0.9-0.91.01.0
Locomotion velocity, session 20.00.00.1-0.4-0.2-0.1-0.3-0.10.00.00.10.0
Locomotion distance, session 20.30.40.7-0.8-0.80.60.60.7-0.6-0.50.60.4
Locomotion velocity, session 30.10.10.2-0.1-0.30.40.40.4-0.4-0.40.30.2
Locomotion distance, session 30.00.00.0-0.0-0.1-0.0-0.0-0.00.10.1-0.1-0.1
Stereotopy head waving bouts, day 30.10.10.20.20.2-0.3-0.4-0.40.20.2-0.2-0.3
Stereotopy head waving duration, day 30.20.20.40.30.4-0.5-0.6-0.60.30.4-0.4-0.6
Locomotion velocity, session 70.20.30.5-0.0-0.30.60.70.5-0.5-0.50.60.6
Locomotion distance, session 70.70.91.2-1.0-0.91.11.01.0-0.9-0.90.80.9
Stereotopy head waving bouts, day 71.61.72.91.71.4-1.3-1.0-1.21.21.2-1.4-1.3
Stereotopy head waving duration, day 70.60.71.71.31.1-0.9-0.6-0.80.70.7-0.7-0.7
Locomotion velocity, session 80.91.12.51.61.1-1.0-0.7-0.51.01.0-1.1-1.0
Locomotion distance, session 80.20.30.70.80.7-0.5-0.20.30.70.6-0.6-0.5
Degree of sensitization distance0.20.20.3-0.6-0.40.60.50.3-0.5-0.50.50.5
Degree of sensitization stereotypy0.30.41.01.00.7-0.6-0.2-0.50.50.5-0.6-0.6
Conditioned locomotion1.41.62.11.41.3-1.3-1.3-1.21.31.2-1.2-1.1
Cocaine response after cond. corrected0.70.81.3-0.3-0.80.70.70.7-1.1-1.11.11.0
Cocaine response after cond. not corrected1.92.12.9-0.9-1.41.41.41.5-1.7-1.71.61.5
Cocaine response before conditioning1.92.33.1-1.7-1.61.61.71.8-1.4-1.31.21.1
Saline control response0.10.10.40.30.00.10.50.6-0.1-0.0-0.2-0.1
Bone: connectivity density0.20.40.60.80.8-0.5-0.3-0.30.70.7-0.6-0.7
Bone: cortical apparent density6.89.011.82.62.9-3.1-3.3-3.42.93.0-2.9-2.8
Bone: cortical area0.30.51.20.60.6-0.7-1.1-1.10.50.5-0.6-0.5
Bone: cortical porosity0.30.30.60.50.4-0.4-0.1-0.10.70.7-0.8-0.7
Bone: cortical porosity0.10.10.20.40.1-0.00.40.50.20.2-0.3-0.2
Bone: cortical thickness0.30.51.20.90.6-0.8-1.0-1.10.30.4-0.5-0.4
Bone: cortical thickness0.91.11.70.90.9-1.1-1.1-0.90.91.0-1.3-1.2
Bone: cortical tissue density7.09.211.92.63.0-3.1-3.3-3.53.03.0-2.9-2.8
Condit. Reinf. active minus inactive responses0.50.60.9-0.6-0.70.70.70.8-0.9-0.90.60.9
Condit. Reinf. active-inactive response ratio2.72.93.9-1.5-1.61.71.71.7-1.7-1.81.72.0
Condit. Reinf. active responses0.10.10.30.1-0.10.10.20.4-0.5-0.50.20.4
Condit. Reinf. inactive responses1.92.22.91.71.6-1.7-1.7-1.41.21.2-1.3-1.5
Incentive salience index mean0.40.50.9-0.2-0.60.60.80.8-0.9-0.90.60.9
Condit. Reinf. lever presses0.10.10.30.2-0.20.30.40.3-0.5-0.50.40.4
Condit. Reinf. active minus inactive responses0.81.01.40.91.1-0.9-0.8-0.71.11.2-1.2-1.1
Condit. Reinf. active-inactive response ratio0.70.81.00.60.9-0.8-0.9-0.61.01.0-1.0-0.9
Condit. Reinf. active responses0.10.10.40.10.3-0.3-0.2-0.00.40.4-0.6-0.5
Condit. Reinf. inactive responses0.30.40.7-0.6-0.70.60.60.8-0.7-0.70.40.4
Condit. Reinf. lever presses0.91.22.2-1.5-1.11.21.11.5-0.8-0.80.80.8
Condit. Reinf. lever reinforcers received0.20.20.50.20.5-0.4-0.20.00.50.6-0.7-0.7
Conditioned reinforcement - actives2.22.23.21.21.5-1.5-1.8-1.51.41.4-1.4-1.5
Conditioned reinforcement - inactives0.60.60.90.70.8-0.8-0.9-0.60.70.7-0.9-0.9
Conditioned locomotion0.20.30.9-0.2-0.30.40.40.9-0.5-0.60.40.3
Patch foraging indifference point 0 sec4.36.910.53.22.9-2.8-2.5-2.62.52.4-2.4-2.2
Patch foraging indifference point AUC2.22.66.22.51.9-1.7-1.6-1.71.21.2-1.1-1.0
Delay disc. indifference point, 0s delay0.30.30.70.60.5-0.5-0.2-0.40.50.5-0.8-0.6
Delay disc. indifference point, 16s delay0.20.21.1-1.0-0.50.40.0-0.2-0.3-0.30.30.7
Delay disc. indifference point, 2s delay0.90.93.0-1.7-1.30.90.70.3-0.7-0.60.70.9
Delay disc. indifference point, 24s delay0.40.40.9-1.0-0.80.60.50.2-0.5-0.50.30.9
Delay disc. indifference point, 4s delay0.20.20.5-0.30.2-0.4-0.5-0.40.50.6-0.7-0.7
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.50.40.20.4-0.2-0.10.10.1
Indifference point function ln k1.31.83.30.91.1-1.3-1.1-0.91.51.5-1.5-1.8
Indifference point function log k1.31.83.30.91.1-1.3-1.1-0.91.51.5-1.5-1.8
Patch foraging total patch changes 0 sec5.08.112.63.53.2-3.0-2.6-2.82.72.6-2.6-2.4
Patch foraging total patch changes 12 sec3.44.45.92.42.2-2.2-2.1-2.42.02.1-1.9-1.4
Patch foraging total patch changes 18 sec1.31.63.21.81.4-1.4-1.1-1.51.01.1-1.1-0.8
Patch foraging total patch changes 24 sec0.30.41.31.20.8-0.7-0.5-0.50.40.5-0.5-0.4
Patch foraging total patch changes 6 sec2.43.58.02.82.2-2.0-2.1-2.01.41.4-1.3-1.0
Patch foraging time to switch 0 sec10.716.619.6-4.4-4.34.24.34.3-3.8-3.83.83.6
Patch foraging water rate 0 sec18.229.234.35.65.5-5.6-5.8-5.95.15.1-5.1-5.0
Patch foraging water rate 12 sec10.516.119.93.43.8-4.2-4.5-3.94.14.1-4.1-4.1
Patch foraging water rate 18 sec5.37.18.22.52.5-2.7-2.6-2.82.72.7-2.9-2.7
Patch foraging water rate 24 sec4.46.16.72.22.3-2.5-2.5-2.52.52.5-2.6-2.5
Patch foraging water rate 6 sec5.17.48.82.72.7-2.8-3.0-2.72.72.6-2.7-2.6
Seeking ratio, delayed vs. immediate footshock0.20.30.50.70.6-0.6-0.4-0.40.50.6-0.5-0.3
Distance traveled before self-admin0.60.61.5-1.0-0.80.70.1-0.0-0.8-0.70.81.2
Distance traveled after self-admin0.50.51.00.40.5-0.7-0.7-0.80.70.8-1.0-0.7
Extensor digitorum longus weight7.529.440.06.35.9-5.6-5.1-4.85.45.3-5.2-5.1
Bone: elastic displacement0.50.50.90.10.3-0.7-0.7-0.90.70.8-0.9-0.8
Bone: elastic work0.10.10.4-0.7-0.2-0.1-0.3-0.30.20.3-0.3-0.1
Bone: endosteal estimation0.20.41.6-1.3-0.70.60.50.7-0.1-0.10.10.1
Bone: endosteal perimeter0.00.10.2-0.5-0.30.2-0.20.2-0.2-0.10.20.1
Epididymis fat weight3.58.210.3-2.5-2.93.03.03.2-2.9-2.92.72.5
Delta time in closed arm before/after self-admin0.00.00.10.20.1-0.1-0.10.30.10.1-0.2-0.3
Delta time in open arm before/after self-admin0.40.40.80.90.6-0.6-0.6-0.60.50.4-0.7-0.5
Diff in mean of infusions in LGA sessions0.10.20.70.60.20.00.0-0.1-0.4-0.40.80.3
Delay discount exponential model param0.10.10.70.80.5-0.3-0.1-0.10.20.1-0.1-0.3
Extinction: sum of active levers before priming0.10.10.2-0.2-0.10.2-0.20.1-0.4-0.40.40.4
Active lever presses in extinction session 61.71.72.21.31.4-1.4-1.5-1.01.41.3-1.0-1.3
Bone: final force0.20.30.5-0.10.3-0.5-0.7-0.50.60.7-0.6-0.4
Bone: final moment0.20.40.60.10.4-0.6-0.8-0.50.70.8-0.7-0.5
Food consumed during 24 hour testing period0.40.51.11.10.7-0.7-0.4-0.40.70.7-0.9-0.8
Glucose0.40.61.40.30.5-0.8-0.9-1.20.50.6-0.8-0.7
Heart weight0.00.00.1-0.2-0.10.1-0.00.10.20.10.10.1
Delay discount hyperbolic model param0.20.20.91.00.6-0.4-0.3-0.20.30.2-0.2-0.4
Intermittent access intake day 1-15 change1.51.51.8-1.3-1.21.21.21.2-1.4-1.31.20.8
Intermittent access intake escalation1.41.41.8-1.3-1.21.21.11.3-1.3-1.31.20.5
Intermittent access intake escalation 20.30.30.5-0.5-0.50.50.40.4-0.7-0.70.60.4
Intermitt. access day 1 inactive lever presses3.03.23.71.91.9-1.9-1.7-1.81.91.9-1.7-1.3
Intermitt. access day 15 inactive lever presses1.11.21.70.91.0-1.1-1.1-1.01.11.1-1.2-1.3
Intermitt. access escalation Index0.20.20.30.20.3-0.3-0.5-0.60.50.5-0.5-0.4
Intermittent access day 1 total infusions0.10.10.40.1-0.20.30.20.7-0.4-0.40.30.3
Intermittent access day 15 total infusions1.31.52.0-1.1-1.21.21.11.4-1.4-1.41.20.6
Intermittent access terminal intake (last 3 days)1.61.82.6-1.3-1.41.31.21.3-1.6-1.51.31.0
Intermittent access total infusions0.30.40.7-0.4-0.60.60.40.8-0.8-0.70.50.3
Intermittent access day 1 locomotion0.40.41.0-0.3-0.50.60.51.0-0.6-0.60.50.6
Intermittent access day 15 total locomotion0.10.10.4-0.2-0.10.20.00.7-0.3-0.30.1-0.2
Intermittent access total locomotion0.10.10.5-0.0-0.20.40.30.7-0.5-0.50.30.1
Intermittent access standard deviation2.72.94.1-1.2-1.51.61.62.0-2.0-2.01.81.5
Left kidney weight1.85.28.32.92.5-2.2-1.9-1.42.42.3-2.3-2.3
Right kidney weight1.23.24.52.11.9-1.7-1.5-0.92.01.9-1.9-1.9
Cocaine induced anxiety1.71.93.50.91.5-1.4-1.7-1.91.41.4-1.2-0.9
Post-drug Anxiety1.21.42.80.81.3-1.2-1.6-1.71.01.1-0.9-0.7
Baseline Anxiety1.41.51.8-1.0-1.31.31.31.3-1.3-1.31.10.9
Tail length4.714.317.14.03.8-3.9-3.8-3.13.63.6-3.9-4.1
Length with tail6.724.634.75.95.4-5.2-4.6-4.04.94.8-5.0-4.7
Length without tail3.16.712.33.53.1-2.7-2.1-2.22.72.5-2.3-1.7
Times rat made contact with spout0.10.10.60.50.3-0.4-0.4-0.80.20.2-0.10.0
Lifetime Intake0.10.10.3-0.4-0.30.30.00.6-0.4-0.40.2-0.0
Liver weight, left2.43.84.72.01.9-2.1-2.2-2.21.71.8-1.8-1.8
Liver weight, right0.00.10.50.70.3-0.0-0.1-0.10.00.00.00.3
Locomotor activity0.10.20.30.40.4-0.4-0.3-0.50.50.6-0.50.1
Locomotor testing distance0.30.41.00.50.6-0.7-0.6-1.00.70.8-0.5-0.1
Locomotor testing rearing2.03.15.2-1.8-1.81.81.61.1-1.7-1.61.92.3
Locomotion in novel chamber6.58.010.42.32.6-2.9-2.8-2.62.92.9-3.0-3.2
Locomotion in novel chamber post-restriction0.10.10.3-0.3-0.30.2-0.00.50.10.1-0.2-0.2
Fecal boli incidents, locomotor time 12.12.33.5-0.9-1.31.51.91.6-1.7-1.71.51.3
Change in fecal boli incidents, locomotor task2.82.63.51.51.7-1.8-1.8-0.61.71.7-1.9-1.4
Time >=10cm from walls, locomotor time 10.30.31.21.10.5-0.20.10.6-0.3-0.40.50.6
Bouts of movement, locomotor time 12.12.24.1-1.3-1.71.62.01.2-1.5-1.51.50.9
Total resting periods, locomotor time 11.92.13.6-1.3-1.71.51.91.2-1.4-1.41.40.7
Rest time, locomotor task time 10.10.10.2-0.5-0.40.20.1-0.3-0.2-0.1-0.1-0.3
Distance moved, locomotor task time 10.30.31.2-0.9-0.30.50.10.3-0.3-0.30.71.1
Vertical activity count, locomotor time 10.20.31.0-0.10.5-0.3-0.6-1.00.50.60.10.2
Time >=10cm from walls, locomotor time 20.60.61.91.41.0-0.8-0.4-1.00.60.5-0.3-0.5
Bouts of movement, locomotor time 21.41.63.20.40.7-1.1-1.2-1.41.41.5-1.8-1.2
Total resting periods, locomotor time 21.11.22.60.30.5-1.0-1.1-1.21.21.3-1.6-1.1
Rest time, locomotor task time 20.10.20.5-0.10.2-0.4-0.7-0.50.20.4-0.4-0.3
Distance moved, locomotor task time 20.40.51.0-0.6-0.50.80.70.3-0.5-0.50.91.0
Vertical activity count, locomotor time 20.10.10.50.30.3-0.00.1-0.70.30.30.00.3
Light reinforcement 10.00.00.10.10.1-0.2-0.0-0.10.10.1-0.3-0.1
Light reinforcement 22.02.73.2-1.6-1.61.61.51.6-1.7-1.71.61.8
Bone: marrow area0.20.31.5-1.2-0.60.60.50.7-0.1-0.10.10.1
Bone: maximum diameter0.10.20.4-0.5-0.50.3-0.1-0.2-0.6-0.50.40.4
Bone: maximum force0.10.20.40.20.4-0.4-0.6-0.60.50.6-0.5-0.3
Bone: maximum moment0.10.20.40.30.4-0.5-0.6-0.50.50.6-0.6-0.4
Mean time between licks in bursts0.50.71.4-0.9-0.90.80.71.2-0.6-0.70.60.7
Mean num. licks in bursts0.20.21.11.10.7-0.5-0.2-0.20.30.3-0.4-0.2
Cd content in liver1.71.93.11.21.4-1.2-1.0-0.51.81.7-1.6-1.6
Co content in liver1.31.51.81.31.3-1.2-1.2-1.01.41.3-1.1-1.2
Cu content in liver2.02.43.2-1.8-1.71.51.11.1-1.6-1.61.81.7
Fe content in liver0.60.71.1-1.1-1.00.80.70.3-0.8-0.70.90.9
K content in liver0.20.20.60.80.5-0.4-0.4-0.40.20.2-0.2-0.3
Mg content in liver0.20.20.50.30.4-0.5-0.7-0.40.40.4-0.4-0.4
Mn content in liver0.50.61.10.50.7-0.7-0.6-0.10.90.9-0.9-1.0
Na content in liver0.40.40.7-0.3-0.50.50.50.1-0.8-0.80.80.7
Rb content in liver1.01.21.60.81.0-1.1-1.1-1.01.31.3-1.2-1.0
Se content in liver0.00.10.2-0.1-0.20.20.30.5-0.2-0.20.20.1
Sr content in liver0.40.30.50.20.5-0.5-0.6-0.40.70.7-0.7-0.5
Zn content in liver0.10.20.40.00.1-0.5-0.6-0.40.30.4-0.5-0.4
Bone: minimum diameter0.81.62.01.11.2-1.3-1.4-1.11.31.3-1.3-1.3
Time in familiar zone, hab. session 10.10.10.3-0.0-0.10.40.60.5-0.1-0.10.30.2
Time in novel zone, hab. session 10.30.30.7-0.8-0.80.50.40.4-0.6-0.50.20.4
Total zone transitions, hab. session 10.20.30.9-0.7-0.70.60.70.9-0.2-0.20.20.3
Total locomotion distance, hab. session 10.40.61.20.30.5-0.6-0.5-0.21.01.0-1.1-1.0
Locomotion velocity, hab. session 10.91.31.80.91.0-1.1-1.1-0.81.31.3-1.3-1.3
Time in familiar zone, hab. session 20.20.20.40.40.00.40.60.5-0.3-0.40.50.6
Time in novel zone, hab. session 20.20.20.7-0.8-0.60.20.10.4-0.3-0.30.00.0
Total zone transitions, hab. session 20.60.71.1-0.6-0.90.81.01.1-0.9-1.00.70.6
Total locomotion distance, hab. session 20.40.51.10.60.5-0.7-0.6-0.60.60.7-1.0-1.0
Locomotion velocity, hab. session 20.60.81.40.80.7-0.9-0.8-0.80.70.8-1.1-1.2
Novel to familiar place preference ratio0.60.60.9-0.9-0.80.80.90.7-0.8-0.80.70.7
Novelty place preference0.40.40.8-0.9-0.70.70.70.5-0.6-0.60.50.5
Time in novel zone, NPP test0.20.20.4-0.6-0.50.50.70.5-0.4-0.40.30.3
Total zone transitions, NPP test0.20.20.60.80.4-0.20.30.50.40.3-0.5-0.6
Total locomotion distance, NPP test0.30.40.70.70.5-0.5-0.2-0.00.70.7-0.9-0.8
Locomotion velocity, NPP test0.30.40.80.60.5-0.5-0.3-0.10.70.7-0.9-0.9
Intraocular pressure0.10.10.3-0.5-0.40.40.50.2-0.1-0.1-0.10.4
Delta distance traveled before/after self-admin0.60.61.60.70.6-0.7-0.0-0.10.80.8-1.1-1.3
Delta ambulatory time before/after self-admin1.71.83.71.21.2-1.3-0.7-0.71.41.5-1.7-1.9
Parametrial fat weight0.00.10.1-0.4-0.40.30.20.1-0.3-0.20.20.2
Pavlov. Cond. lever latency0.60.81.10.50.7-0.9-1.0-0.91.01.1-0.8-1.0
Pavlov. Cond. magazine entry latency0.50.71.5-0.4-0.70.91.20.8-0.7-0.80.80.8
Pavlov. Cond. change in total contacts0.20.20.4-0.1-0.30.50.60.5-0.6-0.60.40.4
Pavlov. Cond. index score0.91.22.0-0.5-0.91.11.41.1-1.1-1.21.01.0
Pavlov. Cond. latency score0.70.81.4-0.4-0.80.91.20.9-1.0-1.00.90.9
Pavlov. Cond. lever contacts1.11.31.8-0.8-1.11.11.21.0-1.3-1.31.11.2
Pavlov. Cond. magazine entry number0.70.91.70.30.8-0.9-1.3-1.20.91.0-0.9-0.9
Pavlov. Cond. intertrial magazine entries6.78.110.73.33.1-3.0-2.9-2.62.72.6-2.7-2.5
Pavlov. Cond. lever-magazine prob. diff.0.80.91.6-0.5-0.81.01.31.0-1.0-1.10.90.9
Pavlov. Cond. response bias0.91.11.8-0.4-0.91.01.31.2-1.1-1.21.01.0
Pavlov. Cond. lever latency1.52.03.61.91.5-1.4-1.3-1.81.21.2-1.0-1.0
Pavlov. Cond. magazine entry latency3.64.26.0-2.1-2.12.12.12.4-2.0-2.01.71.8
Pavlov. Cond. change in total contacts4.05.57.9-2.8-2.52.42.22.4-2.2-2.22.22.2
Pavlov. Cond. index score3.54.56.9-2.4-2.22.22.12.6-1.9-1.91.81.8
Pavlov. Cond. latency score3.64.56.5-2.3-2.12.22.12.5-2.0-2.01.91.9
Pavlov. Cond. lever contacts2.12.94.7-2.1-1.81.71.62.2-1.5-1.51.41.4
Pavlov. Cond. magazine entry number2.73.34.81.91.9-1.8-1.8-2.21.81.7-1.5-1.6
Pavlov. Cond. intertrial magazine entries5.47.07.82.62.8-2.8-2.7-2.82.62.6-2.6-2.6
Pavlov. Cond. lever-magazine prob. diff.4.15.27.4-2.6-2.42.32.22.7-2.1-2.12.02.0
Pavlov. Cond. response bias2.43.36.0-2.1-2.01.81.82.4-1.6-1.61.41.4
Time in closed arm before self-admin4.85.48.4-2.9-2.52.42.21.8-2.1-2.02.22.6
Time in closed arm after self-admin2.02.05.1-2.3-1.71.51.51.3-1.0-1.01.01.1
Time in open arm before self-admin6.77.39.12.72.8-2.8-3.0-2.52.62.6-2.4-2.9
Time in open arm after self-admin4.95.49.93.22.6-2.4-2.4-2.02.12.0-2.0-1.9
Bone: periosteal estimation0.00.10.2-0.4-0.1-0.2-0.4-0.30.20.3-0.4-0.4
Bone: periosteal perimeter0.00.00.2-0.1-0.1-0.1-0.4-0.1-0.1-0.10.00.0
Bone: post-yield work1.72.43.21.81.8-1.4-1.2-1.31.81.7-1.4-1.3
Progressive ratio test 1 active lever presses0.00.00.0-0.2-0.10.0-0.10.1-0.1-0.0-0.2-0.1
Progressive ratio test 1 breakpoint0.00.10.1-0.3-0.30.20.10.2-0.3-0.2-0.00.1
Progressive ratio test 1 inactive lever presses2.93.24.01.71.7-1.9-1.7-1.81.81.9-2.0-1.5
Progressive ratio test 2 active lever presses0.00.00.2-0.1-0.0-0.1-0.30.0-0.0-0.0-0.1-0.4
Progressive ratio test 2 breakpoint0.10.10.30.00.1-0.2-0.40.00.10.1-0.3-0.6
Progressive ratio test 2 inactive lever presses0.91.02.30.40.7-0.9-1.2-1.10.91.0-1.0-1.5
Incentive Sensitization - Responses0.00.00.2-0.2-0.1-0.0-0.20.10.00.1-0.2-0.5
Incentive Sensitization - Breakpoint0.10.10.4-0.20.0-0.2-0.3-0.00.20.2-0.3-0.6
Sum of active levers in priming session hrs 5-60.50.50.9-0.6-0.50.60.20.5-1.0-1.00.90.7
Progressive ratio0.40.51.3-0.80.2-0.4-1.1-0.60.60.6-0.5-0.9
Food seeking constrained by brief footshock0.50.61.90.40.4-0.6-0.8-1.40.80.8-0.7-0.7
Seeking ratio, punishment vs. effort0.10.10.80.90.1-0.10.4-0.30.00.1-0.10.3
Retroperitoneal fat weight0.20.70.9-0.5-0.80.81.00.9-1.0-0.90.70.6
Reaction time number correct3.65.16.32.52.4-2.5-2.2-2.32.12.1-2.0-2.1
Reaction time mean minus median0.10.20.6-0.2-0.40.50.80.6-0.2-0.20.00.2
Reaction time mean minus median AUC0.10.10.4-0.1-0.20.30.60.6-0.0-0.0-0.2-0.1
Reaction time num false alarms1.31.72.31.51.4-1.5-1.4-1.31.11.1-1.3-1.1
Reaction time num false alarms AUC1.72.32.81.61.5-1.7-1.7-1.51.31.4-1.5-1.3
Reaction time trials correct on left3.65.16.32.52.4-2.5-2.2-2.32.12.1-2.0-2.1
Reaction time trials on left3.65.26.42.52.5-2.5-2.2-2.32.12.2-2.1-2.1
Reaction time mean0.91.32.5-1.6-1.31.31.31.4-0.8-0.80.80.5
Reaction time mean AUC0.50.71.4-1.2-0.91.01.11.2-0.5-0.50.50.3
Median of all reaction times0.50.71.9-1.4-0.91.00.91.1-0.4-0.50.50.2
Reaction time omissions1.31.83.41.31.1-1.1-0.6-0.91.41.5-1.8-1.8
Reaction time false alarm rate0.10.10.30.30.3-0.4-0.5-0.40.30.3-0.5-0.2
Reaction time premature initiation rate0.60.91.50.61.0-0.8-1.2-1.20.90.9-0.7-0.8
Reaction time premature initiations2.53.64.51.92.1-1.9-2.1-2.11.81.8-1.5-1.7
Std. dev. reaction times0.50.71.4-1.2-0.91.01.11.0-0.5-0.50.30.3
Reaction time trials completed3.65.26.42.52.5-2.5-2.2-2.32.12.2-2.1-2.1
Reaction time trials AUC3.85.56.72.62.5-2.5-2.3-2.42.22.2-2.1-2.2
Run reversals in cocaine runway, females1.71.63.1-1.6-1.51.31.80.9-1.1-1.11.10.4
Run reversals in cocaine runway, males0.20.20.8-0.00.1-0.2-0.6-0.90.40.4-0.1-0.2
Latency to leave start box in cocaine runway0.30.30.8-0.9-0.70.30.20.2-0.6-0.60.30.7
Latency to leave start box in cocaine runway, F0.50.50.7-0.7-0.70.60.60.1-0.8-0.80.70.9
Latency to leave start box in cocaine runway, M0.20.20.6-0.8-0.60.30.10.2-0.5-0.50.20.6
Std. dev. time between licks in bursts0.10.21.10.30.00.20.41.10.10.1-0.2-0.2
Total sessions with >9 infusions0.00.00.1-0.20.0-0.1-0.30.1-0.1-0.1-0.1-0.3
Short access day 1 total inactive lever presses0.10.10.1-0.00.1-0.2-0.30.20.40.3-0.3-0.3
Short access day 10 total inactive lever presses0.70.71.10.60.7-0.8-0.7-0.61.01.1-1.0-1.0
Short access day 1 total infusions0.40.41.00.20.6-0.7-1.0-0.50.60.6-0.6-0.8
Short access day 10 total infusions0.20.20.4-0.5-0.40.30.10.6-0.5-0.50.30.2
Short access total infusions0.10.10.6-0.7-0.40.3-0.20.4-0.3-0.30.20.0
Short access day 1 locomotion0.30.30.6-0.6-0.50.40.30.7-0.5-0.50.50.6
Short access day 10 total locomotion0.40.40.6-0.3-0.50.60.60.8-0.8-0.80.50.8
Short access total locomotion0.00.00.0-0.2-0.10.1-0.10.2-0.1-0.1-0.00.1
One hour access (0.3 mA shock)0.20.20.50.70.6-0.6-0.7-0.30.30.3-0.4-0.4
Compulsive drug intake0.10.10.50.60.2-0.10.30.20.10.00.00.7
One hour access (shock baseline)0.00.00.1-0.3-0.0-0.1-0.30.1-0.2-0.20.0-0.3
Social response proportion0.30.30.9-0.40.1-0.5-1.0-0.70.60.6-0.3-0.3
Social responses0.10.10.4-0.6-0.40.20.10.1-0.2-0.00.10.3
Social time1.52.03.10.51.2-1.3-1.4-1.01.71.7-1.6-1.8
Soleus weight0.30.84.32.11.2-0.8-0.20.10.60.5-0.6-0.5
Bone: stiffness1.32.02.51.41.5-1.4-1.6-1.41.51.5-1.3-1.2
Tibialis anterior weight0.41.43.01.71.4-1.3-1.2-1.01.11.0-1.0-0.8
Time to tail flick, vehicle, before self-admin0.80.81.91.41.0-1.0-0.6-0.70.80.7-0.8-0.9
Time to tail flick, vehicle, after self-admin0.10.10.60.80.5-0.30.40.30.10.1-0.3-0.1
Time to tail flick, test, before self-admin0.00.00.1-0.2-0.2-0.1-0.3-0.40.10.2-0.20.0
Time to tail flick, test, after self-admin2.22.34.52.11.9-1.6-1.0-1.11.31.3-1.4-1.5
Delta time to tail flick, vehicle, before/after SA0.00.00.10.30.1-0.00.30.2-0.00.0-0.1-0.0
Delta time to tail flick, test, before/after SA2.11.93.92.01.8-1.5-0.7-0.81.21.2-1.3-1.3
Tibia length0.10.30.80.40.4-0.6-0.8-0.90.30.4-0.6-0.5
Ambulatory time before self-admin1.01.01.6-1.1-1.01.00.40.1-1.1-1.01.21.3
Ambulatory time after self-admin0.00.00.1-0.3-0.30.20.1-0.0-0.1-0.0-0.10.1
Bone: tissue strength0.10.10.2-0.5-0.40.20.2-0.2-0.2-0.10.00.1
Total heroin consumption0.70.82.01.41.2-0.9-1.2-0.90.40.4-0.5-0.7
Bone: trabecular number0.20.30.50.70.6-0.5-0.2-0.30.60.6-0.7-0.7
Bone: trabecular spacing0.10.10.1-0.3-0.30.20.10.4-0.3-0.30.20.1
Bone: trabecular thickness0.10.10.20.20.3-0.2-0.3-0.40.20.2-0.3-0.2
Bone: trabecular tissue density0.10.10.5-0.0-0.1-0.1-0.4-0.7-0.1-0.10.20.1
Water consumed over 24 hours2.73.24.01.51.6-1.9-2.0-2.01.81.8-1.8-1.8
Number of responses in last shaping day0.50.51.1-0.8-0.60.60.50.9-0.7-0.60.51.1