Sipa1l3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Sipa1l3 0.06 0.05 2.6e-05 0.05 0.04 0.05 0.05 3.7e-06 2.7e-05 2.9e-06 3.4e-06
2 LHb gene expression Sipa1l3 0.15 0.11 4.1e-03 0.06 0.03 0.03 0.06 1.9e-02 6.4e-02 7.1e-02 1.7e-02
3 PL gene expression Sipa1l3 0.03 0.03 1.0e-04 0.04 0.03 0.03 0.04 3.0e-05 1.8e-04 2.3e-04 7.7e-05
4 LHb mRNA stability Sipa1l3 0.13 0.1 2.5e-03 0.11 0.02 0.1 -0.01 1.4e-03 1.1e-01 2.9e-03 7.7e-01
5 pVTA gene expression Sipa1l3 0.14 0.09 1.6e-05 0.11 0.1 0.09 0.09 1.8e-05 4.4e-05 1.5e-04 8.2e-05
6 NAcc mRNA stability Sipa1l3 0.13 0.09 5.3e-11 0.1 0.09 0.1 0.1 9.2e-12 9.4e-11 4.5e-11 1.4e-11
7 IL gene expression Sipa1l3 0.13 0.1 6.9e-03 0.12 0.02 0.1 0.09 9.9e-04 1.1e-01 1.7e-03 3.5e-03
8 Brain gene expression Sipa1l3 0.2 0.09 0.0e+00 0.28 0.29 0.28 0.28 1.2e-25 2.3e-27 5.5e-26 7.2e-26
9 RMTg gene expression Sipa1l3 0.09 0.07 8.3e-03 0.03 0.06 0.03 0.02 4.4e-02 1.4e-02 5.8e-02 7.6e-02
10 Brain mRNA stability Sipa1l3 0.1 0.06 8.4e-12 0.12 0.13 0.12 0.12 1.7e-11 8.7e-12 1.3e-11 1.6e-11
11 Liver mRNA stability Sipa1l3 0.03 0.02 6.7e-04 0.02 0.02 0.02 0.02 1.4e-03 6.3e-03 3.2e-03 4.4e-03
12 Adipose mRNA stability Sipa1l3 0.04 0.04 7.5e-05 0.03 0.02 0.01 0.03 4.6e-04 1.3e-03 1.8e-02 7.3e-04
13 BLA gene expression Sipa1l3 0.08 0.08 3.0e-03 0.06 0.05 0.02 0.04 5.8e-04 1.4e-03 2.2e-02 2.4e-03
14 IL mRNA stability Sipa1l3 0.28 0.18 4.1e-03 0.09 0.07 0.11 0.07 3.5e-03 8.2e-03 1.6e-03 7.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.10.60.2-0.3-0.2-0.2-0.20.30.30.00.2-0.00.40.30.2-0.8
Area under the delay curve1.31.44.7-1.21.1-1.2-1.1-1.1-1.2-1.31.00.90.8-1.1-1.1-0.1-2.2
BMI with tail0.41.22.11.4-1.20.90.90.91.11.5-1.1-1.1-1.01.01.00.51.2
BMI without tail0.10.30.6-0.50.5-0.8-0.6-0.7-0.3-0.50.50.40.5-0.4-0.4-0.8-0.4
Body weight2.29.313.0-3.13.0-3.3-3.2-3.3-3.0-3.03.23.23.4-2.9-2.7-3.6-0.7
Weight adjusted by age0.20.20.40.5-0.50.40.50.30.60.4-0.6-0.5-0.50.50.60.5-0.0
Bone surface0.50.81.4-0.80.7-1.1-1.1-1.1-0.5-0.71.01.20.9-0.6-0.6-0.8-1.0
Bone volume0.40.61.1-0.70.6-1.0-0.9-0.9-0.5-0.60.91.10.9-0.5-0.6-0.8-0.8
Breakpoint value in progressive ratio session3.64.05.8-2.42.0-2.2-1.9-2.0-2.2-2.32.12.12.0-1.7-1.6-1.1-2.0
Number of licking bursts3.13.64.62.0-1.92.02.02.01.72.0-2.1-2.1-2.01.71.71.61.5
Context. condit. distance diff. score0.00.00.10.0-0.20.10.00.00.3-0.0-0.1-0.2-0.20.30.30.3-0.4
Locomotion velocity, session 11.21.33.41.2-1.20.90.90.91.11.2-1.2-1.1-1.31.11.01.8-0.8
Locomotion distance, session 10.70.91.6-0.81.1-0.7-0.7-0.8-1.2-0.80.90.91.0-1.2-1.3-1.00.1
Locomotion velocity, session 20.30.40.90.5-0.70.30.40.30.90.4-0.6-0.6-0.60.91.00.5-0.5
Locomotion distance, session 21.21.62.31.5-1.31.31.41.31.21.4-1.3-1.3-1.21.21.20.71.3
Locomotion velocity, session 30.40.50.80.6-0.80.60.60.60.90.6-0.7-0.7-0.70.90.90.50.6
Locomotion distance, session 33.84.17.0-2.12.1-2.0-2.0-1.9-2.0-2.12.22.12.3-2.0-1.9-2.70.2
Stereotopy head waving bouts, day 31.31.62.81.1-1.41.11.11.11.71.1-1.1-1.0-1.11.71.70.91.1
Stereotopy head waving duration, day 32.63.15.11.6-2.01.51.51.52.31.5-1.7-1.6-1.82.32.21.80.2
Locomotion velocity, session 70.10.10.5-0.40.1-0.3-0.4-0.30.0-0.40.30.40.20.00.1-0.0-0.7
Locomotion distance, session 70.00.00.1-0.20.2-0.2-0.2-0.1-0.1-0.20.20.30.3-0.1-0.2-0.30.1
Stereotopy head waving bouts, day 70.50.51.00.5-0.70.80.80.80.80.5-0.7-0.8-0.60.80.90.11.0
Stereotopy head waving duration, day 71.62.02.51.3-1.51.51.51.51.51.3-1.5-1.5-1.41.51.61.01.0
Locomotion velocity, session 84.25.06.02.3-2.42.32.22.22.42.2-2.3-2.3-2.32.42.42.01.2
Locomotion distance, session 80.50.70.90.9-0.81.00.91.00.80.8-0.9-0.9-0.90.80.80.70.6
Degree of sensitization distance1.61.64.01.1-1.31.01.01.01.31.1-1.3-1.2-1.41.31.32.0-1.0
Degree of sensitization stereotypy0.60.62.50.6-0.61.01.01.00.50.6-0.7-0.8-0.50.50.6-0.11.6
Conditioned locomotion0.30.43.30.3-0.30.40.40.40.60.2-0.2-0.3-0.00.50.5-0.81.8
Cocaine response after cond. corrected0.10.10.6-0.20.2-0.1-0.1-0.1-0.1-0.20.20.10.3-0.1-0.1-0.80.6
Cocaine response after cond. not corrected0.20.21.2-0.00.0-0.1-0.2-0.10.1-0.00.20.20.30.10.1-0.91.1
Cocaine response before conditioning0.50.61.7-0.50.5-0.8-0.9-0.8-0.3-0.40.91.01.0-0.5-0.4-1.30.9
Saline control response0.20.30.6-0.50.6-0.4-0.4-0.4-0.6-0.50.50.40.6-0.7-0.7-0.80.3
Bone: connectivity density0.20.31.50.4-0.60.00.10.00.70.4-0.3-0.1-0.40.70.60.7-1.2
Bone: cortical apparent density2.33.04.02.0-1.81.71.71.71.71.9-1.9-1.8-1.91.71.61.70.8
Bone: cortical area1.52.23.2-1.51.6-1.5-1.4-1.5-1.5-1.51.61.61.7-1.5-1.5-1.80.1
Bone: cortical porosity2.62.84.11.7-1.81.91.81.81.81.6-1.5-1.4-1.41.81.90.72.0
Bone: cortical porosity3.03.24.81.8-1.92.01.91.91.91.8-1.6-1.6-1.51.92.00.82.2
Bone: cortical thickness0.50.71.4-0.90.9-0.7-0.7-0.7-0.9-0.90.90.91.0-0.9-0.9-1.20.5
Bone: cortical thickness0.91.02.51.0-1.01.11.11.01.01.0-0.9-0.9-0.81.01.10.21.6
Bone: cortical tissue density2.73.54.62.1-2.01.81.81.91.92.1-2.0-2.0-2.01.81.81.90.8
Condit. Reinf. active minus inactive responses0.20.20.50.6-0.50.30.30.30.40.6-0.6-0.5-0.60.40.40.7-0.0
Condit. Reinf. active-inactive response ratio0.10.20.40.3-0.50.20.20.20.40.3-0.4-0.4-0.50.40.50.6-0.1
Condit. Reinf. active responses1.62.03.01.7-1.51.41.41.41.21.7-1.5-1.5-1.51.21.21.11.0
Condit. Reinf. inactive responses1.51.82.81.7-1.31.51.51.51.01.7-1.4-1.4-1.21.00.90.71.4
Incentive salience index mean0.10.10.30.5-0.40.20.10.10.30.5-0.4-0.3-0.30.30.30.20.3
Condit. Reinf. lever presses0.10.10.20.00.2-0.4-0.5-0.4-0.3-0.00.20.30.3-0.3-0.3-0.5-0.0
Condit. Reinf. active minus inactive responses3.34.14.9-2.12.2-2.2-2.2-2.2-1.9-2.12.12.02.1-2.1-2.1-2.1-0.4
Condit. Reinf. active-inactive response ratio0.80.92.8-0.70.9-0.6-0.6-0.6-0.8-0.70.70.51.0-0.9-0.9-1.71.7
Condit. Reinf. active responses4.56.37.5-2.62.7-2.7-2.7-2.7-2.4-2.62.62.62.7-2.5-2.5-2.4-0.9
Condit. Reinf. inactive responses3.24.04.9-2.12.1-2.1-2.1-2.2-1.9-2.12.12.21.9-2.0-2.0-1.2-1.9
Condit. Reinf. lever presses8.912.114.2-3.73.8-3.5-3.6-3.6-3.7-3.73.63.63.6-3.6-3.6-2.7-1.9
Condit. Reinf. lever reinforcers received4.86.87.9-2.72.8-2.7-2.7-2.8-2.5-2.72.72.72.8-2.7-2.7-2.6-0.6
Conditioned reinforcement - actives0.10.10.8-0.10.30.20.50.2-0.0-0.20.1-0.10.1-0.2-0.3-0.60.9
Conditioned reinforcement - inactives1.41.62.6-1.41.5-1.1-0.9-1.1-1.4-1.41.31.21.4-1.3-1.4-1.60.2
Conditioned locomotion2.42.84.71.7-1.62.02.22.01.81.7-1.6-1.6-1.51.61.51.11.7
Patch foraging indifference point 0 sec0.10.20.5-0.40.5-0.1-0.1-0.2-0.5-0.40.40.40.5-0.6-0.6-0.60.7
Patch foraging indifference point AUC0.40.51.21.0-0.80.40.60.40.71.1-0.8-0.8-0.80.60.50.50.3
Delay disc. indifference point, 0s delay1.31.52.2-1.21.3-1.5-1.2-1.4-1.3-1.21.00.90.9-1.2-1.3-0.8-1.5
Delay disc. indifference point, 16s delay3.43.44.5-2.02.0-2.0-1.9-1.9-1.9-2.01.71.61.6-1.9-1.9-1.3-2.1
Delay disc. indifference point, 2s delay1.92.18.6-1.51.3-1.5-1.3-1.4-1.4-1.51.11.00.9-1.4-1.20.2-2.9
Delay disc. indifference point, 24s delay2.72.63.2-1.71.7-1.7-1.7-1.8-1.8-1.61.61.61.5-1.7-1.6-1.1-1.5
Delay disc. indifference point, 4s delay0.20.20.4-0.50.6-0.4-0.3-0.1-0.6-0.50.40.30.4-0.5-0.6-0.2-0.3
Delay disc. indifference point, 8s delay0.30.32.6-0.2-0.1-0.0-0.10.0-0.2-0.20.00.1-0.20.10.21.0-1.6
Indifference point function ln k0.50.71.1-1.00.9-0.5-0.8-0.5-0.9-1.00.90.90.9-0.8-0.8-0.5-0.2
Indifference point function log k0.50.71.1-1.00.9-0.5-0.8-0.5-0.9-1.00.90.90.9-0.8-0.8-0.5-0.2
Patch foraging total patch changes 0 sec0.20.40.8-0.50.7-0.2-0.2-0.3-0.8-0.60.60.60.6-0.9-0.8-0.70.5
Patch foraging total patch changes 12 sec0.20.20.5-0.30.5-0.6-0.5-0.6-0.5-0.20.40.40.4-0.5-0.6-0.70.1
Patch foraging total patch changes 18 sec0.20.20.50.7-0.40.40.60.40.50.7-0.5-0.4-0.50.30.10.20.6
Patch foraging total patch changes 24 sec0.91.12.0-0.91.2-1.1-1.1-1.0-1.1-0.80.90.90.9-1.2-1.4-0.9-0.5
Patch foraging total patch changes 6 sec0.00.10.40.10.2-0.00.1-0.1-0.10.10.00.00.1-0.2-0.3-0.40.6
Patch foraging time to switch 0 sec0.50.81.60.6-0.90.50.40.51.10.6-0.8-0.8-1.01.21.11.3-1.1
Patch foraging water rate 0 sec0.91.42.01.2-1.21.41.41.40.91.2-1.1-1.1-1.01.01.10.91.3
Patch foraging water rate 12 sec0.60.91.6-1.11.1-0.6-0.7-0.6-1.2-1.10.90.71.0-1.3-1.1-0.90.3
Patch foraging water rate 18 sec0.30.41.70.1-0.40.80.80.80.2-0.0-0.5-0.5-0.60.50.71.3-0.4
Patch foraging water rate 24 sec0.10.21.1-0.50.40.1-0.00.0-0.3-0.60.30.20.4-0.3-0.1-0.41.0
Patch foraging water rate 6 sec0.20.30.5-0.70.6-0.3-0.7-0.4-0.7-0.70.70.70.6-0.6-0.6-0.0-0.3
Seeking ratio, delayed vs. immediate footshock1.51.82.5-1.31.4-1.4-1.6-1.4-1.6-1.21.31.31.3-1.4-1.4-1.2-0.7
Distance traveled before self-admin1.01.01.8-1.01.1-0.9-0.8-0.9-1.1-1.01.01.01.1-1.1-1.0-1.40.6
Distance traveled after self-admin5.46.07.3-2.52.6-2.5-2.5-2.6-2.7-2.62.52.52.6-2.5-2.5-2.3-0.8
Extensor digitorum longus weight0.20.70.90.8-0.80.80.80.80.90.8-0.9-0.9-0.90.80.80.80.2
Bone: elastic displacement0.00.00.10.0-0.10.20.30.20.1-0.0-0.1-0.1-0.10.10.10.3-0.0
Bone: elastic work1.62.02.7-1.51.5-1.4-1.3-1.4-1.4-1.51.61.61.6-1.3-1.3-1.70.1
Bone: endosteal estimation1.53.23.8-1.81.9-1.9-1.9-1.9-1.9-1.71.92.01.9-1.8-1.8-1.7-1.1
Bone: endosteal perimeter1.93.84.6-2.02.0-2.1-2.2-2.1-2.0-1.92.02.01.9-2.0-2.0-1.5-1.7
Epididymis fat weight0.00.00.10.3-0.10.2-0.10.30.10.3-0.1-0.1-0.10.0-0.00.00.2
Delta time in closed arm before/after self-admin1.11.01.6-1.01.0-0.9-1.2-0.9-0.9-1.01.11.31.1-1.0-0.9-1.0-0.8
Delta time in open arm before/after self-admin0.80.82.30.9-0.60.91.01.00.80.8-0.9-1.0-0.80.60.40.41.5
Diff in mean of infusions in LGA sessions0.20.20.5-0.50.4-0.5-0.3-0.3-0.7-0.50.50.40.4-0.3-0.3-0.0-0.3
Delay discount exponential model param1.31.34.11.2-1.11.21.11.11.21.2-1.0-0.9-0.81.11.10.12.0
Extinction: sum of active levers before priming1.81.82.8-1.31.4-1.3-1.5-1.3-1.2-1.21.51.71.5-1.5-1.4-1.1-0.7
Active lever presses in extinction session 62.12.03.9-1.51.2-1.7-1.7-1.6-1.2-1.31.51.71.3-1.1-1.1-0.5-2.0
Bone: final force1.21.92.9-1.41.5-1.2-1.3-1.3-1.4-1.41.51.61.6-1.4-1.4-1.70.2
Bone: final moment1.72.84.4-1.71.8-1.5-1.6-1.6-1.7-1.61.81.91.9-1.7-1.7-2.10.3
Food consumed during 24 hour testing period0.70.91.1-0.91.0-1.0-1.0-0.9-1.0-0.90.90.90.9-1.1-1.0-0.5-0.7
Glucose0.20.30.40.6-0.60.60.60.60.50.6-0.6-0.6-0.60.60.60.5-0.1
Heart weight0.30.41.1-0.70.6-0.4-0.6-0.3-0.3-0.70.70.60.7-0.4-0.5-1.00.8
Delay discount hyperbolic model param1.11.24.11.1-1.01.11.01.01.21.1-0.9-0.8-0.71.01.0-0.02.0
Intermittent access intake day 1-15 change1.81.83.0-1.31.6-1.2-1.2-1.2-1.5-1.31.31.21.3-1.6-1.7-1.3-0.8
Intermittent access intake escalation1.71.62.5-1.31.5-1.2-1.2-1.2-1.4-1.21.21.21.2-1.5-1.6-1.2-1.0
Intermittent access intake escalation 22.72.74.0-1.61.8-1.6-1.5-1.6-1.8-1.51.61.51.7-1.9-1.9-2.0-0.3
Intermitt. access day 1 inactive lever presses2.32.55.3-1.51.5-1.7-1.7-1.7-1.6-1.51.51.71.4-1.4-1.4-0.7-2.3
Intermitt. access day 15 inactive lever presses0.80.91.7-0.90.8-1.1-0.9-1.1-1.3-0.90.80.80.8-0.9-0.7-0.3-1.3
Intermitt. access escalation Index0.10.10.4-0.1-0.10.10.40.1-0.3-0.10.1-0.00.10.10.3-0.20.7
Intermittent access day 1 total infusions1.51.76.41.1-1.11.51.71.51.00.9-1.1-1.2-0.91.11.10.52.5
Intermittent access day 15 total infusions0.30.30.6-0.70.7-0.3-0.0-0.2-0.7-0.70.50.30.6-0.7-0.7-0.70.8
Intermittent access terminal intake (last 3 days)0.50.51.8-0.70.8-0.20.1-0.2-0.7-0.80.50.30.6-0.8-0.7-1.01.3
Intermittent access total infusions0.20.32.6-0.10.20.40.60.4-0.2-0.1-0.0-0.10.1-0.2-0.1-0.41.6
Intermittent access day 1 locomotion0.80.83.00.8-0.71.01.21.00.80.7-0.7-0.7-0.60.80.70.11.7
Intermittent access day 15 total locomotion0.10.10.40.3-0.10.40.70.40.30.3-0.2-0.2-0.20.30.1-0.00.3
Intermittent access total locomotion0.91.12.11.1-0.91.21.51.21.01.0-1.0-1.0-1.01.00.80.51.1
Intermittent access standard deviation6.46.89.1-2.82.9-2.5-2.3-2.5-3.0-2.72.72.62.7-2.9-2.9-2.1-1.3
Left kidney weight1.33.79.0-1.51.7-1.9-2.0-1.9-1.7-1.42.12.22.3-1.6-1.7-3.01.2
Right kidney weight3.29.011.7-2.92.9-3.2-3.3-3.2-3.0-2.83.33.43.4-2.8-2.7-3.4-0.3
Cocaine induced anxiety0.30.41.5-0.60.3-0.8-0.8-0.8-0.5-0.50.60.60.4-0.2-0.10.2-1.2
Post-drug Anxiety0.30.43.1-0.2-0.1-0.6-0.6-0.6-0.1-0.2-0.0-0.0-0.20.30.30.8-1.8
Baseline Anxiety0.70.71.11.0-0.80.80.70.80.91.0-0.9-1.0-0.80.70.60.21.0
Tail length5.516.620.0-4.54.4-4.1-3.9-4.0-4.1-4.44.34.14.3-4.1-4.1-4.0-1.8
Length with tail8.129.735.8-6.05.7-5.6-5.5-5.6-5.5-5.95.85.75.8-5.3-5.1-5.4-2.5
Length without tail3.68.09.5-3.12.9-2.8-3.0-2.9-3.0-3.03.13.13.1-2.7-2.5-2.7-1.2
Times rat made contact with spout1.31.52.51.3-1.21.41.41.41.11.3-1.1-1.1-1.11.21.20.41.6
Lifetime Intake0.40.42.40.4-0.40.81.00.80.40.3-0.5-0.5-0.40.40.40.21.6
Liver weight, left0.71.23.21.0-0.91.31.31.31.01.0-0.9-0.9-0.81.00.9-0.01.8
Liver weight, right0.10.10.70.2-0.10.30.70.40.20.1-0.2-0.3-0.20.10.0-0.10.8
Locomotor activity0.71.11.81.2-1.31.01.11.01.11.2-1.0-0.9-0.91.31.30.70.6
Locomotor testing distance0.81.31.81.3-1.31.11.01.11.21.2-1.1-1.0-1.21.21.31.30.4
Locomotor testing rearing2.13.34.11.8-1.91.81.81.72.01.7-1.9-2.0-1.82.02.01.61.3
Locomotion in novel chamber0.10.10.80.1-0.20.20.30.10.10.1-0.2-0.1-0.30.00.20.6-0.9
Locomotion in novel chamber post-restriction0.70.82.5-1.00.9-0.9-1.0-0.9-0.9-1.00.80.80.6-0.9-0.90.1-1.6
Fecal boli incidents, locomotor time 11.51.63.81.1-1.31.31.11.21.21.1-1.2-1.1-1.41.41.42.0-0.9
Change in fecal boli incidents, locomotor task0.10.10.2-0.20.2-0.5-0.3-0.4-0.2-0.20.20.20.3-0.2-0.2-0.50.2
Time >=10cm from walls, locomotor time 10.00.00.10.2-0.20.20.20.30.20.1-0.2-0.2-0.20.20.2-0.10.3
Bouts of movement, locomotor time 12.52.76.8-1.91.6-1.8-1.5-1.6-1.7-1.91.51.31.3-1.4-1.4-0.6-2.6
Total resting periods, locomotor time 12.62.88.4-1.91.6-1.9-1.6-1.7-1.7-1.91.51.31.2-1.4-1.4-0.3-2.9
Rest time, locomotor task time 10.00.00.10.2-0.20.30.20.00.00.2-0.2-0.3-0.20.20.10.2-0.2
Distance moved, locomotor task time 10.10.10.70.3-0.20.00.20.10.50.3-0.2-0.2-0.10.30.3-0.50.9
Vertical activity count, locomotor time 10.60.71.7-0.80.8-0.8-0.8-0.6-0.8-0.80.90.91.0-0.7-0.6-1.30.2
Time >=10cm from walls, locomotor time 20.30.31.50.5-0.30.50.60.60.20.5-0.5-0.6-0.40.20.1-0.21.2
Bouts of movement, locomotor time 20.40.53.4-0.80.5-0.5-0.5-0.5-0.4-0.80.30.20.1-0.4-0.30.4-1.8
Total resting periods, locomotor time 20.20.22.1-0.60.3-0.3-0.3-0.3-0.2-0.60.10.0-0.0-0.2-0.10.4-1.4
Rest time, locomotor task time 20.10.11.4-0.00.10.30.20.2-0.3-0.00.0-0.00.2-0.1-0.1-0.51.2
Distance moved, locomotor task time 20.20.20.40.6-0.50.20.50.20.70.6-0.6-0.6-0.50.60.50.00.3
Vertical activity count, locomotor time 20.50.51.0-0.70.7-0.9-0.8-0.9-0.8-0.70.60.60.6-0.6-0.6-0.5-1.0
Light reinforcement 10.20.30.70.5-0.30.80.70.80.30.6-0.5-0.5-0.50.20.10.40.6
Light reinforcement 24.15.510.32.2-2.52.22.12.22.42.2-2.4-2.3-2.62.52.53.2-0.8
Bone: marrow area1.53.34.0-1.81.9-1.9-1.9-1.9-1.9-1.81.92.01.9-1.8-1.8-1.7-1.0
Bone: maximum diameter1.32.42.9-1.61.6-1.7-1.7-1.6-1.4-1.51.61.61.6-1.4-1.5-1.7-0.6
Bone: maximum force2.34.05.1-2.02.1-1.9-1.9-1.9-2.1-1.92.12.22.2-2.1-2.1-2.3-0.1
Bone: maximum moment3.05.16.8-2.32.4-2.1-2.2-2.1-2.4-2.22.42.42.5-2.4-2.4-2.6-0.0
Mean time between licks in bursts0.00.10.1-0.20.2-0.3-0.4-0.4-0.1-0.30.20.20.2-0.1-0.1-0.40.2
Mean num. licks in bursts0.70.81.4-0.90.9-0.8-0.9-0.9-0.7-0.91.11.11.1-0.7-0.7-1.2-0.2
Cd content in liver0.10.10.60.3-0.30.40.30.30.10.3-0.3-0.2-0.40.20.20.8-0.4
Co content in liver1.21.42.61.3-1.41.00.80.81.31.3-1.2-1.1-1.31.41.41.6-0.4
Cu content in liver0.60.71.4-0.80.9-0.6-0.4-0.6-0.9-0.90.90.80.9-0.9-0.8-1.20.8
Fe content in liver0.10.10.70.2-0.20.10.10.10.10.2-0.2-0.2-0.30.10.20.6-0.8
K content in liver0.20.20.8-0.20.3-0.4-0.4-0.5-0.2-0.20.30.30.4-0.3-0.2-0.90.6
Mg content in liver0.40.42.10.5-0.50.50.60.60.60.5-0.5-0.5-0.40.50.6-0.21.5
Mn content in liver1.31.49.71.0-0.91.11.11.10.81.0-0.7-0.7-0.40.90.9-0.83.1
Na content in liver3.33.56.5-1.92.0-1.9-1.9-1.9-1.8-1.81.91.82.0-1.8-1.8-2.60.1
Rb content in liver0.00.00.1-0.10.20.20.20.1-0.1-0.20.0-0.00.0-0.1-0.1-0.10.3
Se content in liver7.79.512.13.3-3.33.53.33.33.03.2-3.0-3.0-2.93.03.21.83.0
Sr content in liver1.11.01.31.0-1.11.01.01.01.01.0-1.0-0.9-1.01.11.00.90.6
Zn content in liver0.20.30.50.6-0.60.40.40.40.50.6-0.5-0.5-0.60.50.50.7-0.0
Bone: minimum diameter4.58.39.9-3.03.1-2.8-2.9-2.9-3.0-3.03.03.03.2-3.0-3.0-3.1-0.3
Time in familiar zone, hab. session 10.30.30.4-0.50.6-0.5-0.5-0.5-0.6-0.40.60.50.6-0.6-0.6-0.5-0.3
Time in novel zone, hab. session 10.60.61.30.5-0.61.01.01.00.70.4-0.7-0.8-0.60.70.70.41.1
Total zone transitions, hab. session 10.20.30.8-0.20.6-0.2-0.2-0.3-0.8-0.20.40.40.5-0.8-0.8-0.90.7
Total locomotion distance, hab. session 12.94.16.6-2.02.4-1.7-1.7-1.8-2.5-1.92.02.02.1-2.5-2.6-2.1-0.4
Locomotion velocity, hab. session 11.52.23.7-1.31.7-1.3-1.3-1.4-1.8-1.31.41.41.5-1.8-1.9-1.3-0.5
Time in familiar zone, hab. session 22.12.24.1-1.71.5-1.6-1.6-1.6-1.2-1.71.51.51.3-1.2-1.3-0.5-2.0
Time in novel zone, hab. session 21.41.41.91.3-1.21.31.41.30.91.3-1.2-1.2-1.10.91.00.71.3
Total zone transitions, hab. session 21.52.06.31.5-1.21.51.61.51.01.5-1.4-1.5-1.11.00.90.22.5
Total locomotion distance, hab. session 20.20.21.0-0.20.50.00.0-0.0-0.5-0.30.20.20.3-0.5-0.6-0.71.0
Locomotion velocity, hab. session 20.10.21.70.00.20.20.20.1-0.2-0.00.0-0.00.2-0.2-0.3-0.61.3
Novel to familiar place preference ratio0.60.71.7-0.70.9-0.6-0.5-0.6-1.0-0.70.70.60.8-1.0-1.0-1.30.4
Novelty place preference0.50.51.5-0.60.8-0.5-0.4-0.4-0.9-0.50.60.50.7-0.9-1.0-1.20.5
Time in novel zone, NPP test0.30.30.9-0.30.6-0.3-0.2-0.2-0.6-0.30.40.30.5-0.6-0.7-1.00.6
Total zone transitions, NPP test0.10.10.30.5-0.30.50.50.40.10.5-0.4-0.3-0.40.10.10.40.0
Total locomotion distance, NPP test2.53.44.4-1.92.1-1.7-1.7-1.8-2.0-1.91.91.91.9-2.0-2.1-1.4-1.1
Locomotion velocity, NPP test2.83.95.2-2.12.2-1.8-1.8-1.9-2.2-2.02.12.12.0-2.2-2.3-1.6-1.0
Intraocular pressure0.10.21.1-0.20.2-0.4-0.3-0.5-0.5-0.10.20.10.1-0.2-0.30.1-1.0
Delta distance traveled before/after self-admin2.93.16.2-1.81.7-1.9-2.0-2.0-1.6-1.81.71.71.5-1.5-1.7-0.7-2.5
Delta ambulatory time before/after self-admin2.22.43.0-1.61.6-1.6-1.7-1.7-1.4-1.51.71.71.6-1.4-1.5-1.1-1.4
Parametrial fat weight0.81.62.71.5-1.51.10.80.91.61.6-1.2-1.1-1.21.51.40.90.6
Pavlov. Cond. lever latency0.20.32.2-0.50.3-0.5-0.4-0.5-0.2-0.60.20.20.1-0.2-0.20.5-1.5
Pavlov. Cond. magazine entry latency0.20.30.70.4-0.30.80.80.90.30.4-0.5-0.6-0.50.30.30.50.8
Pavlov. Cond. change in total contacts0.10.10.30.3-0.20.30.20.30.00.3-0.2-0.3-0.20.00.0-0.00.5
Pavlov. Cond. index score0.40.52.40.7-0.60.90.80.80.50.7-0.5-0.6-0.40.50.5-0.11.5
Pavlov. Cond. latency score0.20.21.50.5-0.40.50.40.50.30.5-0.3-0.3-0.20.30.3-0.21.2
Pavlov. Cond. lever contacts0.20.31.0-0.30.5-0.2-0.3-0.2-0.5-0.30.50.50.6-0.5-0.5-1.00.9
Pavlov. Cond. magazine entry number0.30.41.3-0.50.4-0.9-0.9-0.9-0.3-0.50.60.60.5-0.3-0.4-0.3-1.1
Pavlov. Cond. intertrial magazine entries0.40.50.80.9-0.80.40.40.40.80.9-0.8-0.8-0.70.80.80.30.5
Pavlov. Cond. lever-magazine prob. diff.0.50.73.90.7-0.51.00.90.90.50.7-0.5-0.6-0.40.50.5-0.32.0
Pavlov. Cond. response bias0.10.11.10.2-0.00.40.40.4-0.10.1-0.1-0.1-0.0-0.1-0.1-0.31.1
Pavlov. Cond. lever latency4.86.47.72.7-2.62.72.82.82.62.6-2.6-2.7-2.62.52.51.91.9
Pavlov. Cond. magazine entry latency3.23.74.3-2.02.0-2.0-2.1-2.0-2.0-2.02.02.01.9-1.9-1.9-1.3-1.7
Pavlov. Cond. change in total contacts8.712.014.4-3.73.6-3.7-3.8-3.8-3.5-3.63.63.53.5-3.4-3.4-2.6-2.4
Pavlov. Cond. index score5.16.57.7-2.72.7-2.7-2.8-2.7-2.6-2.62.62.62.5-2.6-2.5-1.7-2.2
Pavlov. Cond. latency score4.96.17.3-2.52.6-2.7-2.7-2.7-2.5-2.52.52.52.4-2.5-2.5-1.6-2.2
Pavlov. Cond. lever contacts4.46.07.1-2.62.6-2.6-2.7-2.6-2.6-2.62.52.52.5-2.5-2.4-1.8-1.7
Pavlov. Cond. magazine entry number3.64.36.32.1-2.12.32.32.32.12.0-2.0-2.0-1.92.12.11.02.5
Pavlov. Cond. intertrial magazine entries2.12.73.41.8-1.71.81.81.71.61.8-1.6-1.5-1.51.61.61.11.8
Pavlov. Cond. lever-magazine prob. diff.5.06.47.2-2.62.7-2.6-2.7-2.6-2.6-2.62.62.62.5-2.6-2.6-1.9-1.9
Pavlov. Cond. response bias5.06.88.1-2.72.7-2.8-2.8-2.8-2.7-2.72.62.62.6-2.6-2.6-2.0-1.8
Time in closed arm before self-admin0.70.81.90.7-1.00.90.90.90.50.8-0.9-1.1-0.81.01.10.61.4
Time in closed arm after self-admin0.50.51.3-0.80.4-0.9-1.1-0.9-0.8-0.70.80.80.6-0.2-0.1-0.3-1.0
Time in open arm before self-admin1.82.03.4-1.21.3-1.5-1.6-1.6-1.1-1.11.61.91.6-1.3-1.3-1.5-1.0
Time in open arm after self-admin0.30.31.9-0.10.4-0.10.1-0.0-0.0-0.10.40.40.6-0.5-0.5-1.11.4
Bone: periosteal estimation2.04.04.8-2.12.1-2.1-2.1-2.1-2.0-2.02.22.22.2-2.0-2.0-2.1-0.6
Bone: periosteal perimeter2.23.64.2-2.02.0-2.0-2.1-2.0-2.0-1.91.91.91.9-2.0-1.9-1.7-1.1
Bone: post-yield work1.72.32.8-1.51.6-1.7-1.6-1.6-1.6-1.51.51.51.4-1.6-1.7-0.9-1.5
Progressive ratio test 1 active lever presses0.50.61.5-0.70.7-0.2-0.1-0.2-0.6-0.80.80.80.9-0.6-0.5-1.11.2
Progressive ratio test 1 breakpoint0.80.91.8-1.01.0-0.5-0.4-0.5-0.8-1.01.11.11.2-0.8-0.7-1.31.1
Progressive ratio test 1 inactive lever presses0.91.01.6-1.11.0-1.1-1.1-1.1-1.1-1.10.90.90.9-0.9-0.8-0.4-1.2
Progressive ratio test 2 active lever presses0.30.40.7-0.70.7-0.4-0.2-0.4-0.7-0.70.60.50.6-0.8-0.7-0.60.3
Progressive ratio test 2 breakpoint0.30.30.6-0.50.6-0.2-0.1-0.2-0.7-0.50.50.40.6-0.8-0.6-0.60.7
Progressive ratio test 2 inactive lever presses3.64.25.9-2.32.3-2.0-1.6-2.0-2.4-2.32.01.92.0-2.4-2.3-1.6-1.1
Incentive Sensitization - Responses0.10.10.3-0.20.3-0.2-0.1-0.2-0.3-0.20.20.10.1-0.5-0.40.0-0.4
Incentive Sensitization - Breakpoint0.00.00.2-0.10.2-0.10.0-0.1-0.2-0.10.0-0.0-0.0-0.4-0.30.2-0.5
Sum of active levers in priming session hrs 5-60.00.00.1-0.20.1-0.10.0-0.10.1-0.30.20.30.20.10.1-0.20.0
Progressive ratio0.10.11.10.2-0.10.2-0.00.0-0.10.3-0.1-0.0-0.2-0.1-0.00.5-1.0
Food seeking constrained by brief footshock3.54.35.6-2.12.2-2.0-2.2-2.0-2.3-2.02.22.32.2-2.4-2.3-1.7-0.9
Seeking ratio, punishment vs. effort1.11.31.8-1.31.3-1.2-1.1-1.0-1.2-1.31.21.11.3-1.0-1.1-1.20.4
Retroperitoneal fat weight1.96.17.92.8-2.62.72.52.72.42.8-2.5-2.5-2.42.32.31.52.4
Reaction time number correct0.50.73.50.7-0.60.81.00.80.90.6-0.5-0.5-0.30.70.6-0.21.9
Reaction time mean minus median0.10.10.2-0.30.3-0.4-0.2-0.4-0.3-0.30.40.40.4-0.3-0.3-0.40.2
Reaction time mean minus median AUC0.10.10.2-0.30.3-0.3-0.2-0.3-0.3-0.30.40.50.5-0.2-0.3-0.50.5
Reaction time num false alarms1.21.72.21.3-1.41.41.51.31.21.3-1.4-1.4-1.31.31.40.90.7
Reaction time num false alarms AUC1.62.22.81.6-1.61.61.71.51.41.5-1.5-1.5-1.51.51.71.20.8
Reaction time trials correct on left0.50.73.50.7-0.60.81.00.80.90.6-0.5-0.5-0.30.70.6-0.21.9
Reaction time trials on left0.50.73.50.7-0.60.81.00.90.90.6-0.5-0.5-0.40.80.7-0.21.9
Reaction time mean0.10.10.30.5-0.50.30.30.10.20.5-0.3-0.2-0.30.30.40.30.0
Reaction time mean AUC0.30.30.70.8-0.80.50.50.40.50.8-0.5-0.4-0.50.70.70.50.2
Median of all reaction times0.20.30.70.8-0.70.50.50.30.40.8-0.5-0.4-0.50.50.60.5-0.0
Reaction time omissions0.40.61.30.6-0.90.70.80.71.00.6-0.6-0.6-0.61.11.10.50.5
Reaction time false alarm rate0.60.91.30.9-1.00.90.90.80.70.9-1.0-1.0-1.10.81.01.1-0.5
Reaction time premature initiation rate0.20.30.9-0.60.6-0.5-0.5-0.5-0.3-0.60.40.40.3-0.5-0.60.1-1.0
Reaction time premature initiations0.00.00.0-0.20.2-0.10.2-0.00.2-0.20.10.10.1-0.0-0.10.10.1
Std. dev. reaction times0.00.00.1-0.10.1-0.2-0.1-0.3-0.1-0.10.20.30.3-0.00.0-0.10.2
Reaction time trials completed0.50.73.50.7-0.60.81.00.90.90.6-0.5-0.5-0.40.80.7-0.21.9
Reaction time trials AUC0.71.04.10.9-0.91.01.11.01.10.8-0.7-0.6-0.51.00.9-0.02.0
Run reversals in cocaine runway, females0.10.10.20.2-0.20.30.40.50.10.1-0.2-0.1-0.20.10.20.4-0.3
Run reversals in cocaine runway, males1.61.52.41.4-1.51.10.91.11.51.4-1.1-0.9-1.11.51.51.20.9
Latency to leave start box in cocaine runway0.10.10.30.1-0.20.20.40.20.20.1-0.1-0.2-0.20.50.30.10.1
Latency to leave start box in cocaine runway, F0.40.51.00.6-0.70.60.80.60.70.5-0.6-0.6-0.61.00.90.70.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.40.4-0.4-0.2-0.3-0.6-0.40.30.20.3-0.3-0.4-0.4-0.3
Std. dev. time between licks in bursts1.31.62.4-1.41.2-1.5-1.5-1.5-1.0-1.41.21.11.1-0.9-0.9-0.9-1.5
Total sessions with >9 infusions2.12.37.51.4-1.31.71.81.71.41.3-1.2-1.2-1.01.51.20.12.7
Short access day 1 total inactive lever presses1.21.31.9-1.31.3-1.2-1.2-1.2-1.3-1.41.00.90.9-1.1-1.2-0.4-1.3
Short access day 10 total inactive lever presses2.22.46.4-1.51.4-1.9-1.7-1.9-1.4-1.41.41.51.2-1.3-1.4-0.4-2.5
Short access day 1 total infusions0.10.21.60.0-0.00.30.40.30.2-0.0-0.1-0.10.00.20.2-0.31.3
Short access day 10 total infusions1.01.13.40.9-0.81.41.51.50.80.7-0.9-0.8-0.80.80.80.71.9
Short access total infusions1.51.74.31.2-1.11.61.61.61.11.0-1.1-1.1-1.01.21.20.62.1
Short access day 1 locomotion2.52.73.91.8-1.81.81.71.82.01.7-1.6-1.4-1.51.81.81.01.2
Short access day 10 total locomotion0.20.20.6-0.40.5-0.3-0.2-0.3-0.4-0.40.60.70.6-0.5-0.6-0.80.3
Short access total locomotion1.51.64.11.3-1.11.51.71.51.21.2-1.1-1.0-1.01.11.00.22.0
One hour access (0.3 mA shock)1.51.72.6-1.51.5-1.2-1.0-1.2-1.6-1.51.41.31.3-1.5-1.5-1.0-0.5
Compulsive drug intake0.80.81.4-0.90.8-1.1-1.2-1.1-0.8-0.80.60.50.6-0.8-0.8-0.5-1.2
One hour access (shock baseline)0.10.10.2-0.40.4-0.00.1-0.0-0.4-0.50.40.40.4-0.4-0.3-0.30.4
Social response proportion2.93.24.5-2.01.7-1.9-1.7-1.9-1.5-1.92.12.12.1-1.3-1.3-2.1-0.0
Social responses0.50.61.5-0.80.5-1.0-0.9-1.0-0.4-0.80.81.00.7-0.3-0.3-0.2-1.2
Social time1.82.33.1-1.61.4-1.6-1.7-1.6-1.6-1.61.61.71.5-1.4-1.3-0.6-1.8
Soleus weight0.41.12.50.9-0.91.41.21.30.90.9-1.0-0.9-1.10.90.91.6-0.3
Bone: stiffness1.32.12.4-1.51.5-1.4-1.4-1.4-1.5-1.41.51.61.6-1.5-1.5-1.5-0.4
Tibialis anterior weight0.00.10.60.3-0.20.50.40.50.20.3-0.3-0.4-0.20.20.2-0.10.8
Time to tail flick, vehicle, before self-admin0.80.84.20.9-0.61.00.60.91.00.9-0.7-0.7-0.50.70.5-0.52.0
Time to tail flick, vehicle, after self-admin0.60.71.1-0.80.8-1.0-0.9-1.0-0.8-0.70.70.70.7-0.9-0.9-0.2-1.0
Time to tail flick, test, before self-admin0.60.62.40.7-0.70.90.70.70.80.7-0.6-0.7-0.50.70.7-0.51.5
Time to tail flick, test, after self-admin0.30.30.80.5-0.60.40.20.40.60.6-0.4-0.4-0.30.70.7-0.10.9
Delta time to tail flick, vehicle, before/after SA0.80.81.8-0.90.7-1.1-0.7-1.1-0.9-0.90.80.80.7-0.8-0.6-0.1-1.4
Delta time to tail flick, test, before/after SA0.20.10.50.3-0.40.20.30.50.30.3-0.3-0.2-0.20.50.40.30.7
Tibia length1.64.66.1-2.12.1-2.2-2.3-2.3-2.0-2.12.42.52.4-2.0-1.9-2.4-0.3
Ambulatory time before self-admin0.60.60.9-0.80.8-0.6-0.7-0.7-0.9-0.90.80.80.8-0.8-0.7-0.90.5
Ambulatory time after self-admin6.97.69.2-2.92.9-2.8-2.8-2.9-2.9-3.02.93.02.9-2.7-2.8-2.2-1.4
Bone: tissue strength3.63.54.5-2.02.1-1.7-1.6-1.6-2.0-1.92.01.92.1-2.1-2.1-2.1-0.0
Total heroin consumption1.11.32.1-1.11.3-0.9-0.9-0.9-1.4-1.11.31.31.3-1.3-1.3-1.20.3
Bone: trabecular number0.30.51.1-0.50.4-0.9-0.9-0.9-0.3-0.40.70.90.6-0.3-0.4-0.5-1.1
Bone: trabecular spacing1.11.42.1-1.31.4-0.9-1.0-1.0-1.4-1.41.21.11.3-1.4-1.3-1.40.4
Bone: trabecular thickness0.50.61.00.9-1.00.60.60.60.91.0-0.7-0.7-0.71.01.00.40.6
Bone: trabecular tissue density2.43.43.91.9-2.01.81.81.81.91.9-1.9-1.9-2.01.91.91.90.5
Water consumed over 24 hours0.20.31.4-0.20.3-0.5-0.4-0.4-0.2-0.20.50.60.6-0.3-0.3-1.20.8
Number of responses in last shaping day1.01.03.0-1.11.0-0.9-0.6-0.9-1.1-1.21.00.81.1-0.9-0.8-1.70.7