Hub : Genes

Sim2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Sim2 0.03 0.02 2.7e-03 0.01 0.01 0 0 1.6e-02 6.5e-02 1.9e-01 1.4e-01
2 BLA gene expression Sim2 0.06 0.05 6.7e-03 0.05 0.01 0.02 0.03 1.9e-03 9.0e-02 4.1e-02 1.1e-02
3 Brain mRNA stability Sim2 0.06 0.04 1.8e-05 0.06 0.06 0.04 0.06 1.1e-06 4.9e-06 5.3e-05 3.4e-06
4 OFC gene expression Sim2 0.16 0.1 2.2e-03 0.08 0.11 0.05 0.03 7.5e-03 1.7e-03 2.3e-02 6.2e-02
5 Brain gene expression Sim2 0.1 0.05 1.4e-07 0.07 0.08 0.08 0.07 1.5e-07 1.1e-07 1.0e-07 4.8e-07
6 PL gene expression Sim2 0.07 0.04 2.2e-06 0.05 0.04 0.04 0.05 1.7e-06 1.0e-05 1.9e-05 3.0e-06
7 NAcc gene expression Sim2 0.02 0.01 9.2e-03 0.02 0.01 0.02 0.01 9.5e-04 5.7e-03 9.1e-04 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.30.51.00.40.60.2-0.71.00.90.9
Area under the delay curve1.42.23.4-0.3-0.41.5-1.81.81.71.8
BMI with tail0.31.22.01.21.1-0.3-0.51.31.41.3
BMI without tail0.21.02.20.1-0.00.7-1.21.51.31.2
Body weight0.10.20.4-0.1-0.50.4-0.60.60.60.5
Weight adjusted by age0.20.71.7-1.3-1.11.0-0.80.0-0.1-0.2
Bone surface1.93.89.72.93.1-2.11.20.31.11.1
Bone volume1.22.35.42.32.3-1.50.60.61.11.2
Breakpoint value in progressive ratio session0.30.60.90.30.9-0.71.0-0.9-0.6-0.6
Number of licking bursts0.20.81.5-0.6-0.60.9-1.21.10.70.7
Context. condit. distance diff. score0.20.20.5-0.5-0.50.30.3-0.7-0.4-0.4
Locomotion velocity, session 10.10.10.20.10.2-0.20.5-0.5-0.5-0.4
Locomotion distance, session 10.40.51.10.30.8-0.51.1-1.0-0.6-0.5
Locomotion velocity, session 20.30.40.9-0.10.1-0.30.8-0.9-0.7-0.6
Locomotion distance, session 20.10.20.4-0.3-0.10.6-0.40.20.40.6
Locomotion velocity, session 33.84.37.61.92.1-2.62.8-1.9-1.3-1.4
Locomotion distance, session 30.30.40.90.80.9-0.60.20.30.60.5
Stereotopy head waving bouts, day 31.61.93.01.11.1-1.71.7-1.2-1.4-1.3
Stereotopy head waving duration, day 31.31.62.61.11.1-1.61.5-1.1-1.1-1.1
Locomotion velocity, session 70.70.82.2-1.5-1.31.2-0.5-0.2-0.5-0.3
Locomotion distance, session 71.72.25.1-2.1-1.32.3-1.60.70.50.7
Stereotopy head waving bouts, day 73.44.07.11.81.2-2.42.7-2.0-1.8-1.7
Stereotopy head waving duration, day 73.54.38.01.71.1-2.42.8-2.3-1.9-1.8
Locomotion velocity, session 82.53.05.31.71.7-2.32.3-1.6-1.0-1.0
Locomotion distance, session 80.10.10.3-0.6-0.40.50.0-0.4-0.0-0.0
Degree of sensitization distance1.41.64.4-2.1-1.41.9-1.0-0.0-0.3-0.1
Degree of sensitization stereotypy2.62.85.01.91.3-2.22.2-1.5-1.1-1.1
Conditioned locomotion0.40.51.1-0.9-1.00.7-0.2-0.4-0.6-0.6
Cocaine response after cond. corrected0.71.12.2-0.4-0.3-0.21.1-1.5-1.4-1.4
Cocaine response after cond. not corrected0.81.12.1-0.8-0.60.20.9-1.4-1.4-1.4
Cocaine response before conditioning0.10.20.3-0.4-0.10.6-0.50.30.40.3
Saline control response1.01.42.31.11.5-1.41.5-1.1-0.6-0.7
Bone: connectivity density0.61.02.41.31.5-0.5-0.10.91.11.0
Bone: cortical apparent density0.00.00.00.10.1-0.1-0.10.20.10.0
Bone: cortical area0.81.42.80.20.2-1.01.6-1.7-1.3-1.3
Bone: cortical porosity0.50.60.9-0.8-0.91.0-1.00.60.40.4
Bone: cortical porosity0.40.40.9-0.9-0.81.0-0.70.30.20.1
Bone: cortical thickness1.72.94.4-1.8-2.00.60.7-1.9-2.0-2.1
Bone: cortical thickness0.20.30.8-0.6-0.90.5-0.3-0.1-0.3-0.4
Bone: cortical tissue density0.00.00.10.20.2-0.1-0.20.30.20.1
Condit. Reinf. active minus inactive responses0.00.00.0-0.1-0.10.00.1-0.1-0.10.0
Condit. Reinf. active-inactive response ratio0.30.30.5-0.5-0.50.20.3-0.6-0.7-0.6
Condit. Reinf. active responses0.00.00.0-0.0-0.00.00.0-0.10.10.2
Condit. Reinf. inactive responses0.00.10.10.20.3-0.30.3-0.2-0.1-0.2
Incentive salience index mean0.10.10.2-0.5-0.40.4-0.2-0.00.00.1
Condit. Reinf. lever presses0.20.30.6-0.8-0.80.6-0.2-0.3-0.2-0.2
Condit. Reinf. active minus inactive responses0.20.30.50.60.7-0.60.6-0.50.1-0.0
Condit. Reinf. active-inactive response ratio0.40.61.20.10.20.5-0.80.91.11.1
Condit. Reinf. active responses1.31.83.40.91.3-1.51.8-1.6-1.0-1.1
Condit. Reinf. inactive responses1.92.85.10.71.2-1.72.3-2.1-1.7-1.7
Condit. Reinf. lever presses0.81.22.11.01.1-1.41.5-1.1-0.7-0.7
Condit. Reinf. lever reinforcers received1.31.83.31.01.4-1.51.8-1.5-0.9-0.9
Conditioned reinforcement - actives0.41.53.4-1.7-1.61.8-1.20.40.20.2
Conditioned reinforcement - inactives1.33.56.2-2.5-2.51.00.4-1.7-2.1-1.9
Conditioned locomotion0.20.30.5-0.7-0.60.20.3-0.7-0.7-0.6
Patch foraging indifference point 0 sec1.33.66.6-1.5-1.70.21.2-2.3-2.6-2.5
Patch foraging indifference point AUC0.71.62.91.00.8-1.61.7-1.5-1.0-1.1
Delay disc. indifference point, 0s delay1.11.32.80.1-0.00.8-1.21.31.51.7
Delay disc. indifference point, 16s delay0.60.91.6-0.1-0.10.8-1.21.31.01.2
Delay disc. indifference point, 2s delay1.41.62.80.20.10.8-1.41.61.71.7
Delay disc. indifference point, 24s delay0.61.02.0-1.0-1.01.4-1.20.70.60.7
Delay disc. indifference point, 4s delay1.41.52.80.00.31.0-1.41.51.71.7
Delay disc. indifference point, 8s delay0.71.11.9-0.9-1.21.4-1.30.90.70.8
Indifference point function ln k0.30.92.0-1.2-1.41.2-1.10.50.20.2
Indifference point function log k0.30.92.0-1.2-1.41.2-1.10.50.20.2
Patch foraging total patch changes 0 sec1.13.26.1-1.2-1.50.01.3-2.3-2.5-2.4
Patch foraging total patch changes 12 sec2.43.25.20.80.7-1.82.3-2.2-1.9-2.0
Patch foraging total patch changes 18 sec1.02.34.00.40.2-1.31.9-2.0-1.8-1.9
Patch foraging total patch changes 24 sec0.31.12.50.50.1-1.11.3-1.6-0.9-0.9
Patch foraging total patch changes 6 sec3.05.19.30.10.0-1.62.7-3.0-2.8-2.8
Patch foraging time to switch 0 sec0.21.01.6-0.10.50.7-1.11.31.31.2
Patch foraging water rate 0 sec0.72.74.61.61.3-2.12.1-1.6-1.3-1.3
Patch foraging water rate 12 sec0.41.52.7-1.5-1.61.00.0-1.1-1.3-1.3
Patch foraging water rate 18 sec0.10.31.01.00.2-0.6-0.10.40.70.5
Patch foraging water rate 24 sec0.10.20.5-0.5-0.70.7-0.3-0.1-0.0-0.2
Patch foraging water rate 6 sec0.10.10.4-0.2-0.30.10.3-0.6-0.4-0.4
Seeking ratio, delayed vs. immediate footshock1.01.42.80.0-0.20.7-1.61.71.41.4
Distance traveled before self-admin0.30.71.40.40.1-0.91.2-1.1-0.9-0.8
Distance traveled after self-admin0.81.42.50.20.10.7-1.31.61.51.6
Extensor digitorum longus weight2.510.023.64.94.7-4.02.00.51.41.3
Bone: elastic displacement0.10.20.4-0.5-0.70.5-0.40.2-0.1-0.2
Bone: elastic work0.10.20.30.1-0.1-0.30.5-0.5-0.5-0.5
Bone: endosteal estimation1.64.09.22.73.0-1.70.51.01.71.9
Bone: endosteal perimeter0.71.74.31.72.1-1.61.3-0.50.20.4
Epididymis fat weight0.10.50.90.90.8-0.90.9-0.60.1-0.0
Delta time in closed arm before/after self-admin2.92.75.00.10.41.1-2.02.22.12.1
Delta time in open arm before/after self-admin0.20.30.50.70.5-0.70.7-0.4-0.2-0.1
Diff in mean of infusions in LGA sessions1.73.15.31.01.8-1.92.3-2.0-1.5-1.5
Delay discount exponential model param1.41.92.90.40.4-1.41.7-1.6-1.6-1.7
Extinction: sum of active levers before priming0.91.32.60.10.5-0.91.5-1.6-1.3-1.3
Active lever presses in extinction session 63.33.36.3-0.5-0.0-1.12.0-2.4-2.5-2.5
Bone: final force0.50.71.50.50.8-1.01.2-1.0-0.7-0.6
Bone: final moment0.50.91.70.60.8-1.11.3-1.1-0.8-0.7
Food consumed during 24 hour testing period0.40.71.1-1.0-0.90.40.3-0.8-1.1-1.1
Glucose3.04.89.32.93.0-3.12.3-0.9-0.2-0.2
Heart weight0.60.91.80.60.30.1-1.01.31.21.3
Delay discount hyperbolic model param1.51.93.00.30.4-1.31.7-1.6-1.7-1.7
Intermittent access intake day 1-15 change0.10.81.3-1.1-0.40.10.5-1.1-1.1-1.1
Intermittent access intake escalation0.10.51.1-1.1-0.30.20.3-0.9-0.9-0.9
Intermittent access intake escalation 20.61.12.1-0.50.1-0.61.2-1.5-1.3-1.3
Intermitt. access day 1 inactive lever presses0.22.05.3-2.3-2.21.5-0.6-0.5-0.8-0.8
Intermitt. access day 15 inactive lever presses0.52.65.3-1.1-0.9-0.51.5-2.3-2.1-1.9
Intermitt. access escalation Index0.10.20.6-0.5-0.80.7-0.60.20.10.1
Intermittent access day 1 total infusions0.31.02.7-1.5-1.71.1-0.5-0.4-0.5-0.4
Intermittent access day 15 total infusions1.02.55.6-2.4-1.81.00.1-1.4-1.7-1.6
Intermittent access terminal intake (last 3 days)1.22.25.1-2.3-1.81.10.1-1.3-1.5-1.4
Intermittent access total infusions1.51.84.3-2.1-1.81.1-0.1-1.0-1.2-1.1
Intermittent access day 1 locomotion1.22.25.4-2.3-2.12.1-1.20.0-0.3-0.1
Intermittent access day 15 total locomotion0.72.64.8-1.5-0.9-0.01.3-2.1-2.2-2.1
Intermittent access total locomotion2.93.57.3-2.7-2.11.20.4-1.8-2.1-1.9
Intermittent access standard deviation0.31.83.4-0.7-0.0-0.71.5-1.8-1.8-1.8
Left kidney weight0.97.113.7-3.3-3.33.7-3.21.60.80.8
Right kidney weight0.85.311.4-3.4-3.43.1-2.10.4-0.4-0.4
Cocaine induced anxiety0.20.61.2-0.4-0.6-0.30.7-1.1-1.1-0.9
Post-drug Anxiety0.40.51.30.0-0.0-0.50.9-1.2-0.8-0.6
Baseline Anxiety0.71.22.3-0.10.11.0-1.31.41.51.3
Tail length0.52.76.4-2.4-2.51.4-0.3-0.9-1.4-1.4
Length with tail0.21.03.2-1.4-1.80.9-0.4-0.5-0.6-0.6
Length without tail0.10.40.70.40.0-0.70.8-0.9-0.6-0.6
Times rat made contact with spout4.85.512.0-3.5-3.42.4-0.8-1.1-1.9-1.9
Lifetime Intake0.81.02.4-1.6-1.51.3-0.7-0.1-0.4-0.4
Liver weight, left2.44.211.3-2.6-3.42.5-2.10.7-0.1-0.1
Liver weight, right1.62.85.3-2.3-2.12.2-2.01.10.30.3
Locomotor activity1.92.97.4-2.7-2.22.4-1.4-0.0-0.3-0.4
Locomotor testing distance0.61.64.0-2.0-1.71.4-0.5-0.5-0.8-0.9
Locomotor testing rearing0.20.82.0-1.2-0.91.4-1.00.50.30.1
Locomotion in novel chamber0.10.20.4-0.2-0.0-0.30.4-0.6-0.6-0.6
Locomotion in novel chamber post-restriction0.20.51.21.10.7-0.6-0.10.70.70.7
Fecal boli incidents, locomotor time 10.41.01.9-0.3-0.60.9-1.21.11.31.4
Change in fecal boli incidents, locomotor task1.11.22.9-1.7-1.51.5-0.90.1-0.5-0.4
Time >=10cm from walls, locomotor time 10.60.71.9-0.5-0.7-0.10.6-1.0-1.4-1.0
Bouts of movement, locomotor time 10.20.20.50.40.7-0.50.5-0.4-0.2-0.2
Total resting periods, locomotor time 10.20.20.50.20.7-0.40.5-0.5-0.2-0.3
Rest time, locomotor task time 10.81.23.00.21.20.6-0.80.91.71.5
Distance moved, locomotor task time 10.10.30.8-0.1-0.9-0.20.1-0.1-0.8-0.6
Vertical activity count, locomotor time 10.10.91.90.5-0.4-1.01.0-0.9-1.4-1.1
Time >=10cm from walls, locomotor time 20.10.30.91.00.4-0.70.00.50.50.5
Bouts of movement, locomotor time 20.20.72.01.40.7-1.21.0-0.5-0.10.2
Total resting periods, locomotor time 20.10.20.50.60.2-0.60.7-0.6-0.30.0
Rest time, locomotor task time 20.20.40.9-1.00.30.50.3-0.9-0.6-0.6
Distance moved, locomotor task time 20.60.81.91.10.0-0.5-0.61.40.91.0
Vertical activity count, locomotor time 20.30.72.11.40.3-0.9-0.10.90.80.9
Light reinforcement 10.20.71.50.40.30.4-0.81.01.21.2
Light reinforcement 21.22.86.52.52.6-1.70.80.41.21.1
Bone: marrow area1.74.19.72.83.1-1.80.61.01.82.0
Bone: maximum diameter0.81.62.91.31.4-1.61.7-1.2-0.6-0.5
Bone: maximum force0.40.81.40.80.9-1.21.2-0.9-0.6-0.5
Bone: maximum moment0.40.81.40.80.9-1.21.2-0.9-0.6-0.5
Mean time between licks in bursts0.31.74.4-2.1-1.61.9-1.10.1-0.3-0.3
Mean num. licks in bursts0.82.24.1-1.1-1.10.01.1-1.9-2.0-2.0
Cd content in liver0.80.91.61.31.2-0.8-0.10.90.91.0
Co content in liver0.50.61.20.40.10.5-0.81.01.11.1
Cu content in liver0.20.20.6-0.4-0.80.20.0-0.4-0.5-0.6
Fe content in liver1.82.33.60.4-0.1-1.51.8-1.8-1.9-1.8
K content in liver0.30.30.50.70.7-0.3-0.20.60.70.5
Mg content in liver0.40.51.01.00.7-0.5-0.20.70.90.7
Mn content in liver0.20.20.30.50.5-0.1-0.00.30.60.6
Na content in liver2.22.54.82.12.2-2.21.7-0.8-0.1-0.4
Rb content in liver0.40.51.0-0.4-1.00.8-0.90.60.50.5
Se content in liver0.40.51.1-0.6-0.60.00.4-0.7-1.1-0.8
Sr content in liver0.90.82.1-1.0-1.11.5-1.00.50.20.2
Zn content in liver0.00.00.00.1-0.00.00.1-0.1-0.2-0.1
Bone: minimum diameter2.24.29.82.83.1-2.72.0-0.60.30.3
Time in familiar zone, hab. session 10.00.00.2-0.20.00.4-0.20.10.20.1
Time in novel zone, hab. session 10.40.50.91.00.9-0.6-0.10.80.60.6
Total zone transitions, hab. session 11.01.44.0-2.0-1.51.6-0.7-0.3-0.4-0.2
Total locomotion distance, hab. session 10.91.33.4-1.8-1.51.6-0.90.1-0.3-0.3
Locomotion velocity, hab. session 11.01.43.8-1.9-1.61.6-0.90.0-0.2-0.2
Time in familiar zone, hab. session 20.50.61.30.60.80.2-0.40.81.11.0
Time in novel zone, hab. session 20.10.10.3-0.4-0.6-0.0-0.0-0.1-0.5-0.3
Total zone transitions, hab. session 20.91.23.1-1.6-1.01.8-1.10.30.50.5
Total locomotion distance, hab. session 22.22.96.6-2.2-1.72.6-1.91.00.80.8
Locomotion velocity, hab. session 22.12.86.2-2.3-1.62.5-1.90.90.70.7
Novel to familiar place preference ratio0.10.20.5-0.1-0.00.3-0.60.70.40.4
Novelty place preference0.30.41.10.30.30.1-0.71.10.80.8
Time in novel zone, NPP test0.50.61.30.50.50.0-0.71.11.00.9
Total zone transitions, NPP test0.10.20.4-0.6-0.40.50.1-0.5-0.2-0.2
Total locomotion distance, NPP test0.40.51.2-0.9-0.61.1-0.80.50.40.4
Locomotion velocity, NPP test0.50.71.6-1.1-0.81.3-0.90.50.30.4
Intraocular pressure0.20.40.80.7-0.2-0.4-0.50.90.70.7
Delta distance traveled before/after self-admin4.55.08.0-0.3-0.22.0-2.82.82.82.7
Delta ambulatory time before/after self-admin3.05.17.9-0.4-0.52.1-2.82.82.82.7
Parametrial fat weight2.45.710.32.93.2-1.2-0.62.32.72.5
Pavlov. Cond. lever latency0.10.10.30.00.10.2-0.40.50.50.4
Pavlov. Cond. magazine entry latency0.20.30.7-0.7-0.80.7-0.50.2-0.1-0.0
Pavlov. Cond. change in total contacts0.00.00.20.0-0.40.2-0.20.10.10.0
Pavlov. Cond. index score0.00.00.1-0.3-0.30.2-0.1-0.1-0.2-0.1
Pavlov. Cond. latency score0.10.10.2-0.4-0.40.4-0.20.0-0.1-0.1
Pavlov. Cond. lever contacts0.30.40.8-0.00.0-0.30.7-0.9-0.8-0.7
Pavlov. Cond. magazine entry number0.10.10.30.20.3-0.40.5-0.4-0.2-0.4
Pavlov. Cond. intertrial magazine entries4.95.811.92.72.3-3.53.0-2.0-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.20.1-0.0-0.1-0.2-0.1
Pavlov. Cond. response bias0.10.10.2-0.3-0.40.10.1-0.3-0.5-0.3
Pavlov. Cond. lever latency0.71.01.9-1.2-1.21.4-1.20.90.30.4
Pavlov. Cond. magazine entry latency0.20.30.7-0.3-0.2-0.20.5-0.8-0.6-0.7
Pavlov. Cond. change in total contacts0.20.51.11.01.0-1.00.6-0.20.20.2
Pavlov. Cond. index score0.60.91.70.30.4-1.01.2-1.3-1.0-1.1
Pavlov. Cond. latency score0.30.41.0-0.00.0-0.50.8-1.0-0.7-0.8
Pavlov. Cond. lever contacts0.71.12.11.31.3-1.51.2-0.7-0.2-0.2
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.20.2-0.00.0-0.2-0.1
Pavlov. Cond. intertrial magazine entries0.20.40.80.60.7-0.70.9-0.7-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.50.81.60.20.2-0.91.1-1.3-1.0-1.0
Pavlov. Cond. response bias0.81.12.11.11.2-1.51.3-1.0-0.4-0.5
Time in closed arm before self-admin0.20.30.70.70.8-0.2-0.00.40.60.5
Time in closed arm after self-admin7.78.715.20.71.21.8-3.33.93.93.8
Time in open arm before self-admin0.10.10.2-0.3-0.30.4-0.40.30.20.1
Time in open arm after self-admin2.32.64.70.60.2-1.62.2-2.1-1.7-1.7
Bone: periosteal estimation0.71.73.71.71.9-1.71.4-0.50.10.2
Bone: periosteal perimeter0.61.32.60.81.0-1.21.6-1.4-0.9-0.7
Bone: post-yield work0.91.62.81.21.0-1.71.6-1.2-0.9-1.0
Progressive ratio test 1 active lever presses1.01.73.6-1.9-1.91.8-1.30.30.00.1
Progressive ratio test 1 breakpoint1.01.63.4-1.8-1.81.8-1.30.30.10.1
Progressive ratio test 1 inactive lever presses0.61.74.4-2.1-1.81.3-0.5-0.6-0.9-0.9
Progressive ratio test 2 active lever presses1.62.25.3-2.3-1.81.3-0.1-1.1-1.4-1.5
Progressive ratio test 2 breakpoint1.72.14.9-2.2-1.81.2-0.0-1.1-1.4-1.5
Progressive ratio test 2 inactive lever presses1.54.66.9-2.4-2.20.61.2-2.6-2.6-2.6
Incentive Sensitization - Responses0.61.63.0-1.2-0.70.10.9-1.5-1.7-1.7
Incentive Sensitization - Breakpoint0.81.93.5-1.2-0.70.01.0-1.7-1.9-1.9
Sum of active levers in priming session hrs 5-61.61.52.7-0.10.2-1.01.5-1.6-1.6-1.5
Progressive ratio0.20.41.00.70.5-1.00.8-0.5-0.5-0.5
Food seeking constrained by brief footshock0.70.82.0-1.4-1.21.2-0.70.2-0.4-0.4
Seeking ratio, punishment vs. effort0.30.71.8-1.3-0.71.3-0.90.50.00.1
Retroperitoneal fat weight1.25.210.33.23.1-1.7-0.01.72.42.3
Reaction time number correct0.10.40.80.2-0.2-0.50.8-0.9-0.7-0.8
Reaction time mean minus median0.10.71.4-0.8-0.8-0.10.5-0.9-1.1-1.2
Reaction time mean minus median AUC0.21.42.5-0.2-0.4-0.91.3-1.5-1.5-1.6
Reaction time num false alarms1.12.04.5-2.1-2.01.8-0.9-0.2-0.6-0.7
Reaction time num false alarms AUC1.02.45.3-2.3-2.12.2-1.40.1-0.2-0.3
Reaction time trials correct on left0.10.40.80.2-0.2-0.50.8-0.9-0.7-0.8
Reaction time trials on left0.10.50.90.2-0.1-0.50.8-0.9-0.8-0.9
Reaction time mean0.10.20.40.30.4-0.3-0.30.70.40.4
Reaction time mean AUC0.00.00.10.00.2-0.30.20.1-0.2-0.2
Median of all reaction times0.50.81.70.70.8-0.2-0.61.31.01.1
Reaction time omissions0.10.10.2-0.20.10.4-0.40.40.30.2
Reaction time false alarm rate1.62.34.8-2.1-2.02.2-1.60.50.10.1
Reaction time premature initiation rate0.81.32.51.51.6-1.0-0.00.71.11.1
Reaction time premature initiations0.30.81.91.41.3-1.20.7-0.20.20.2
Std. dev. reaction times0.10.50.9-1.0-0.80.20.1-0.5-0.8-0.9
Reaction time trials completed0.10.50.90.2-0.1-0.50.8-0.9-0.8-0.9
Reaction time trials AUC0.20.50.90.50.2-0.71.0-0.9-0.7-0.8
Run reversals in cocaine runway, females0.20.31.1-0.6-1.10.4-0.3-0.2-0.2-0.2
Run reversals in cocaine runway, males0.50.51.6-0.1-0.3-0.50.8-1.3-0.7-0.7
Latency to leave start box in cocaine runway0.30.50.80.1-0.10.5-0.90.90.90.9
Latency to leave start box in cocaine runway, F1.01.32.3-0.3-0.31.2-1.51.51.21.2
Latency to leave start box in cocaine runway, M0.20.20.30.40.4-0.60.5-0.5-0.2-0.2
Std. dev. time between licks in bursts0.71.22.4-0.8-0.7-0.00.9-1.5-1.6-1.5
Total sessions with >9 infusions0.30.40.8-0.5-0.50.8-0.90.80.40.4
Short access day 1 total inactive lever presses0.51.02.0-1.4-1.10.50.1-0.7-1.3-1.2
Short access day 10 total inactive lever presses0.00.30.40.20.6-0.60.6-0.4-0.5-0.5
Short access day 1 total infusions0.30.61.5-0.3-0.40.9-1.21.20.60.5
Short access day 10 total infusions0.50.81.6-0.3-0.31.0-1.31.20.80.9
Short access total infusions0.50.71.5-0.4-0.51.0-1.21.10.70.7
Short access day 1 locomotion0.61.02.2-1.3-0.81.5-1.40.90.30.3
Short access day 10 total locomotion0.00.20.3-0.10.60.4-0.40.30.40.5
Short access total locomotion0.10.20.6-0.5-0.10.8-0.60.40.30.3
One hour access (0.3 mA shock)1.72.03.1-1.8-1.70.60.6-1.4-1.6-1.6
Compulsive drug intake0.30.51.41.20.8-0.60.10.50.60.5
One hour access (shock baseline)1.23.14.8-2.1-1.80.40.8-1.9-2.2-2.1
Social response proportion0.30.41.6-0.8-1.30.6-0.7-0.1-0.0-0.1
Social responses0.60.71.3-1.1-1.21.2-1.10.30.30.2
Social time0.00.00.10.2-0.2-0.20.2-0.0-0.1-0.0
Soleus weight0.51.43.71.71.9-1.30.9-0.10.50.5
Bone: stiffness0.20.30.60.00.2-0.50.7-0.8-0.6-0.5
Tibialis anterior weight4.415.335.15.95.9-4.92.30.81.81.9
Time to tail flick, vehicle, before self-admin0.60.71.8-0.9-0.00.10.3-0.7-1.3-1.3
Time to tail flick, vehicle, after self-admin0.40.92.21.51.0-0.7-0.00.71.11.0
Time to tail flick, test, before self-admin2.73.15.7-1.4-1.22.2-2.41.81.51.4
Time to tail flick, test, after self-admin1.61.62.9-0.7-0.71.6-1.71.41.31.3
Delta time to tail flick, vehicle, before/after SA0.80.92.11.50.6-0.70.10.61.21.1
Delta time to tail flick, test, before/after SA0.10.10.20.20.1-0.30.5-0.4-0.3-0.2
Tibia length0.00.00.1-0.1-0.3-0.0-0.20.10.00.1
Ambulatory time before self-admin0.51.62.90.90.9-1.51.7-1.4-1.1-1.0
Ambulatory time after self-admin0.50.81.80.60.50.1-0.71.11.21.3
Bone: tissue strength0.30.30.6-0.6-0.70.8-0.70.30.20.3
Total heroin consumption0.81.01.5-1.2-1.00.40.5-1.2-1.2-1.1
Bone: trabecular number0.30.50.80.40.70.2-0.60.90.90.8
Bone: trabecular spacing1.42.05.2-2.0-2.31.8-1.20.2-0.2-0.2
Bone: trabecular thickness0.50.71.61.31.3-1.10.50.10.30.3
Bone: trabecular tissue density0.81.43.0-1.5-1.31.7-1.30.60.30.6
Water consumed over 24 hours0.30.61.3-1.1-1.00.70.0-0.6-0.8-0.8
Number of responses in last shaping day1.62.14.2-1.6-1.52.1-1.91.20.70.6