Hub : Genes

Sim2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Sim2 0.03 0.02 2.7e-03 0.01 0.01 0 0 1.6e-02 6.5e-02 1.9e-01 1.4e-01
2 BLA gene expression Sim2 0.06 0.05 6.7e-03 0.05 0.01 0.02 0.03 1.9e-03 9.0e-02 4.1e-02 1.2e-02
3 Brain mRNA stability Sim2 0.06 0.04 1.8e-05 0.06 0.06 0.04 0.06 1.1e-06 4.9e-06 5.3e-05 3.7e-06
4 OFC gene expression Sim2 0.16 0.1 2.2e-03 0.08 0.11 0.05 0.03 7.5e-03 1.7e-03 2.3e-02 6.1e-02
5 Brain gene expression Sim2 0.1 0.05 1.4e-07 0.07 0.08 0.08 0.07 1.5e-07 1.1e-07 1.0e-07 4.8e-07
6 PL gene expression Sim2 0.07 0.04 2.2e-06 0.05 0.04 0.04 0.05 1.7e-06 1.0e-05 1.9e-05 3.1e-06
7 NAcc gene expression Sim2 0.02 0.01 9.2e-03 0.02 0.01 0.02 0.01 9.5e-04 5.7e-03 9.1e-04 2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.30.51.0-0.4-0.6-0.2-0.7-1.0-0.9-0.9
Area under the delay curve1.82.23.40.30.4-1.5-1.8-1.8-1.7-1.8
BMI with tail0.31.22.0-1.2-1.10.3-0.5-1.3-1.4-1.3
BMI without tail0.31.02.2-0.10.0-0.7-1.2-1.5-1.3-1.2
Body weight0.10.20.40.10.5-0.4-0.6-0.6-0.6-0.5
Weight adjusted by age0.40.71.71.31.1-1.0-0.8-0.00.10.2
Bone surface2.13.89.7-2.9-3.12.11.2-0.3-1.1-1.1
Bone volume1.32.35.4-2.3-2.31.50.6-0.6-1.1-1.2
Breakpoint value in progressive ratio session0.50.60.9-0.3-0.90.71.00.90.60.6
Number of licking bursts0.50.81.50.60.6-0.9-1.2-1.1-0.7-0.7
Context. condit. distance diff. score0.20.20.50.50.5-0.30.30.70.40.4
Locomotion velocity, session 10.10.10.2-0.1-0.20.20.50.50.50.4
Locomotion distance, session 10.40.51.1-0.3-0.80.51.11.00.60.5
Locomotion velocity, session 20.30.40.90.1-0.10.30.80.90.70.6
Locomotion distance, session 20.10.20.40.30.1-0.6-0.4-0.2-0.4-0.6
Locomotion velocity, session 33.84.37.6-1.9-2.12.62.81.91.31.4
Locomotion distance, session 30.30.40.9-0.8-0.90.60.2-0.3-0.6-0.5
Stereotopy head waving bouts, day 31.61.93.0-1.1-1.11.71.71.21.41.3
Stereotopy head waving duration, day 31.31.62.6-1.1-1.11.61.51.11.11.1
Locomotion velocity, session 70.70.82.21.51.3-1.2-0.50.20.50.3
Locomotion distance, session 71.72.25.12.11.3-2.3-1.6-0.7-0.5-0.7
Stereotopy head waving bouts, day 73.54.07.1-1.8-1.22.42.72.01.81.7
Stereotopy head waving duration, day 73.64.38.0-1.7-1.12.42.82.31.91.8
Locomotion velocity, session 82.53.05.3-1.7-1.72.32.31.61.01.0
Locomotion distance, session 80.10.10.30.60.4-0.50.00.40.00.0
Degree of sensitization distance1.51.64.42.11.4-1.9-1.00.00.30.1
Degree of sensitization stereotypy2.62.85.0-1.9-1.32.22.21.51.11.1
Conditioned locomotion0.40.51.10.91.0-0.7-0.20.40.60.6
Cocaine response after cond. corrected0.91.12.20.40.30.21.11.51.41.4
Cocaine response after cond. not corrected0.91.12.10.80.6-0.20.91.41.41.4
Cocaine response before conditioning0.10.20.30.40.1-0.6-0.5-0.3-0.4-0.3
Saline control response1.11.42.3-1.1-1.51.41.51.10.60.7
Bone: connectivity density0.71.02.4-1.3-1.50.5-0.1-0.9-1.1-1.0
Bone: cortical apparent density0.00.00.0-0.1-0.10.1-0.1-0.2-0.1-0.0
Bone: cortical area0.91.42.8-0.2-0.21.01.61.71.31.3
Bone: cortical porosity0.50.60.90.80.9-1.0-1.0-0.6-0.4-0.4
Bone: cortical porosity0.40.40.90.90.8-1.0-0.7-0.3-0.2-0.1
Bone: cortical thickness1.82.94.41.82.0-0.60.71.92.02.1
Bone: cortical thickness0.20.30.80.60.9-0.5-0.30.10.30.4
Bone: cortical tissue density0.00.00.1-0.2-0.20.1-0.2-0.3-0.2-0.1
Condit. Reinf. active minus inactive responses0.00.00.00.10.1-0.00.10.10.1-0.0
Condit. Reinf. active-inactive response ratio0.30.30.50.50.5-0.20.30.60.70.6
Condit. Reinf. active responses0.00.00.00.00.0-0.00.00.1-0.1-0.2
Condit. Reinf. inactive responses0.00.10.1-0.2-0.30.30.30.20.10.2
Incentive salience index mean0.10.10.20.50.4-0.4-0.20.0-0.0-0.1
Condit. Reinf. lever presses0.20.30.60.80.8-0.6-0.20.30.20.2
Condit. Reinf. active minus inactive responses0.20.30.5-0.6-0.70.60.60.5-0.10.0
Condit. Reinf. active-inactive response ratio0.50.61.2-0.1-0.2-0.5-0.8-0.9-1.1-1.1
Condit. Reinf. active responses1.31.83.4-0.9-1.31.51.81.61.01.1
Condit. Reinf. inactive responses2.22.85.1-0.7-1.21.72.32.11.71.7
Condit. Reinf. lever presses0.91.22.1-1.0-1.11.41.51.10.70.7
Condit. Reinf. lever reinforcers received1.31.83.3-1.0-1.41.51.81.50.90.9
Conditioned reinforcement - actives0.91.53.41.71.6-1.8-1.2-0.4-0.2-0.2
Conditioned reinforcement - inactives2.43.56.22.52.5-1.00.41.72.11.9
Conditioned locomotion0.30.30.50.70.6-0.20.30.70.70.6
Patch foraging indifference point 0 sec1.93.66.61.51.7-0.21.22.32.62.5
Patch foraging indifference point AUC1.11.62.9-1.0-0.81.61.71.51.01.1
Delay disc. indifference point, 0s delay1.21.32.8-0.10.0-0.8-1.2-1.3-1.5-1.7
Delay disc. indifference point, 16s delay0.80.91.60.10.1-0.8-1.2-1.3-1.0-1.2
Delay disc. indifference point, 2s delay1.41.62.8-0.2-0.1-0.8-1.4-1.6-1.7-1.7
Delay disc. indifference point, 24s delay0.81.02.01.01.0-1.4-1.2-0.7-0.6-0.7
Delay disc. indifference point, 4s delay1.41.52.8-0.0-0.3-1.0-1.4-1.5-1.7-1.7
Delay disc. indifference point, 8s delay0.91.11.90.91.2-1.4-1.3-0.9-0.7-0.8
Indifference point function ln k0.50.92.01.21.4-1.2-1.1-0.5-0.2-0.2
Indifference point function log k0.50.92.01.21.4-1.2-1.1-0.5-0.2-0.2
Patch foraging total patch changes 0 sec1.73.26.11.21.5-0.01.32.32.52.4
Patch foraging total patch changes 12 sec2.53.25.2-0.8-0.71.82.32.21.92.0
Patch foraging total patch changes 18 sec1.52.34.0-0.4-0.21.31.92.01.81.9
Patch foraging total patch changes 24 sec0.61.12.5-0.5-0.11.11.31.60.90.9
Patch foraging total patch changes 6 sec3.35.19.3-0.1-0.01.62.73.02.82.8
Patch foraging time to switch 0 sec0.51.01.60.1-0.5-0.7-1.1-1.3-1.3-1.2
Patch foraging water rate 0 sec1.32.74.6-1.6-1.32.12.11.61.31.3
Patch foraging water rate 12 sec0.71.52.71.51.6-1.00.01.11.31.3
Patch foraging water rate 18 sec0.20.31.0-1.0-0.20.6-0.1-0.4-0.7-0.5
Patch foraging water rate 24 sec0.10.20.50.50.7-0.7-0.30.10.00.2
Patch foraging water rate 6 sec0.10.10.40.20.3-0.10.30.60.40.4
Seeking ratio, delayed vs. immediate footshock1.11.42.8-0.00.2-0.7-1.6-1.7-1.4-1.4
Distance traveled before self-admin0.50.71.4-0.4-0.10.91.21.10.90.8
Distance traveled after self-admin1.11.42.5-0.2-0.1-0.7-1.3-1.6-1.5-1.6
Extensor digitorum longus weight2.510.023.6-4.9-4.74.02.0-0.5-1.4-1.3
Bone: elastic displacement0.10.20.40.50.7-0.5-0.4-0.20.10.2
Bone: elastic work0.10.20.3-0.10.10.30.50.50.50.5
Bone: endosteal estimation1.84.09.2-2.7-3.01.70.5-1.0-1.7-1.9
Bone: endosteal perimeter0.81.74.3-1.7-2.11.61.30.5-0.2-0.4
Epididymis fat weight0.10.50.9-0.9-0.80.90.90.6-0.10.0
Delta time in closed arm before/after self-admin2.92.75.0-0.1-0.4-1.1-2.0-2.2-2.1-2.1
Delta time in open arm before/after self-admin0.30.30.5-0.7-0.50.70.70.40.20.1
Diff in mean of infusions in LGA sessions2.63.15.3-1.0-1.81.92.32.01.51.5
Delay discount exponential model param1.71.92.9-0.4-0.41.41.71.61.61.7
Extinction: sum of active levers before priming1.21.32.6-0.1-0.50.91.51.61.31.3
Active lever presses in extinction session 63.33.36.30.50.01.12.02.42.52.5
Bone: final force0.50.71.5-0.5-0.81.01.21.00.70.6
Bone: final moment0.50.91.7-0.6-0.81.11.31.10.80.7
Food consumed during 24 hour testing period0.50.71.11.00.9-0.40.30.81.11.1
Glucose3.04.89.3-2.9-3.03.12.30.90.20.2
Heart weight0.60.91.8-0.6-0.3-0.1-1.0-1.3-1.2-1.3
Delay discount hyperbolic model param1.71.93.0-0.3-0.41.31.71.61.71.7
Intermittent access intake day 1-15 change0.40.81.31.10.4-0.10.51.11.11.1
Intermittent access intake escalation0.30.51.11.10.3-0.20.30.90.90.9
Intermittent access intake escalation 20.91.12.10.5-0.10.61.21.51.31.3
Intermitt. access day 1 inactive lever presses0.52.05.32.32.2-1.5-0.60.50.80.8
Intermitt. access day 15 inactive lever presses1.22.65.31.10.90.51.52.32.11.9
Intermitt. access escalation Index0.20.20.60.50.8-0.7-0.6-0.2-0.1-0.1
Intermittent access day 1 total infusions0.61.02.71.51.7-1.1-0.50.40.50.4
Intermittent access day 15 total infusions1.72.55.62.41.8-1.00.11.41.71.6
Intermittent access terminal intake (last 3 days)1.72.25.12.31.8-1.10.11.31.51.4
Intermittent access total infusions1.51.84.32.11.8-1.1-0.11.01.21.1
Intermittent access day 1 locomotion1.82.25.42.32.1-2.1-1.2-0.00.30.1
Intermittent access day 15 total locomotion1.42.64.81.50.90.01.32.12.22.1
Intermittent access total locomotion2.93.57.32.72.1-1.20.41.82.11.9
Intermittent access standard deviation0.91.83.40.70.00.71.51.81.81.8
Left kidney weight1.57.113.73.33.3-3.7-3.2-1.6-0.8-0.8
Right kidney weight1.25.311.43.43.4-3.1-2.1-0.40.40.4
Cocaine induced anxiety0.40.61.20.40.60.30.71.11.10.9
Post-drug Anxiety0.50.51.3-0.00.00.50.91.20.80.6
Baseline Anxiety1.11.22.30.1-0.1-1.0-1.3-1.4-1.5-1.3
Tail length0.72.76.42.42.5-1.4-0.30.91.41.4
Length with tail0.21.03.21.41.8-0.9-0.40.50.60.6
Length without tail0.10.40.7-0.4-0.00.70.80.90.60.6
Times rat made contact with spout4.85.512.03.53.4-2.4-0.81.11.91.9
Lifetime Intake0.81.02.41.61.5-1.3-0.70.10.40.4
Liver weight, left2.54.211.32.63.4-2.5-2.1-0.70.10.1
Liver weight, right1.62.85.32.32.1-2.2-2.0-1.1-0.3-0.3
Locomotor activity1.92.97.42.72.2-2.4-1.40.00.30.4
Locomotor testing distance0.91.64.02.01.7-1.4-0.50.50.80.9
Locomotor testing rearing0.40.82.01.20.9-1.4-1.0-0.5-0.3-0.1
Locomotion in novel chamber0.10.20.40.20.00.30.40.60.60.6
Locomotion in novel chamber post-restriction0.30.51.2-1.1-0.70.6-0.1-0.7-0.7-0.7
Fecal boli incidents, locomotor time 10.71.01.90.30.6-0.9-1.2-1.1-1.3-1.4
Change in fecal boli incidents, locomotor task1.21.22.91.71.5-1.5-0.9-0.10.50.4
Time >=10cm from walls, locomotor time 10.70.71.90.50.70.10.61.01.41.0
Bouts of movement, locomotor time 10.20.20.5-0.4-0.70.50.50.40.20.2
Total resting periods, locomotor time 10.20.20.5-0.2-0.70.40.50.50.20.3
Rest time, locomotor task time 11.01.23.0-0.2-1.2-0.6-0.8-0.9-1.7-1.5
Distance moved, locomotor task time 10.20.30.80.10.90.20.10.10.80.6
Vertical activity count, locomotor time 10.40.91.9-0.50.41.01.00.91.41.1
Time >=10cm from walls, locomotor time 20.20.30.9-1.0-0.40.70.0-0.5-0.5-0.5
Bouts of movement, locomotor time 20.50.72.0-1.4-0.71.21.00.50.1-0.2
Total resting periods, locomotor time 20.10.20.5-0.6-0.20.60.70.60.3-0.0
Rest time, locomotor task time 20.30.40.91.0-0.3-0.50.30.90.60.6
Distance moved, locomotor task time 20.70.81.9-1.1-0.00.5-0.6-1.4-0.9-1.0
Vertical activity count, locomotor time 20.50.72.1-1.4-0.30.9-0.1-0.9-0.8-0.9
Light reinforcement 10.30.71.5-0.4-0.3-0.4-0.8-1.0-1.2-1.2
Light reinforcement 21.82.86.5-2.5-2.61.70.8-0.4-1.2-1.1
Bone: marrow area1.94.19.7-2.8-3.11.80.6-1.0-1.8-2.0
Bone: maximum diameter0.91.62.9-1.3-1.41.61.71.20.60.5
Bone: maximum force0.50.81.4-0.8-0.91.21.20.90.60.5
Bone: maximum moment0.40.81.4-0.8-0.91.21.20.90.60.5
Mean time between licks in bursts0.71.74.42.11.6-1.9-1.1-0.10.30.3
Mean num. licks in bursts1.42.24.11.11.1-0.01.11.92.02.0
Cd content in liver0.80.91.6-1.3-1.20.8-0.1-0.9-0.9-1.0
Co content in liver0.50.61.2-0.4-0.1-0.5-0.8-1.0-1.1-1.1
Cu content in liver0.20.20.60.40.8-0.20.00.40.50.6
Fe content in liver1.92.33.6-0.40.11.51.81.81.91.8
K content in liver0.30.30.5-0.7-0.70.3-0.2-0.6-0.7-0.5
Mg content in liver0.50.51.0-1.0-0.70.5-0.2-0.7-0.9-0.7
Mn content in liver0.20.20.3-0.5-0.50.1-0.0-0.3-0.6-0.6
Na content in liver2.32.54.8-2.1-2.22.21.70.80.10.4
Rb content in liver0.40.51.00.41.0-0.8-0.9-0.6-0.5-0.5
Se content in liver0.40.51.10.60.6-0.00.40.71.10.8
Sr content in liver0.90.82.11.01.1-1.5-1.0-0.5-0.2-0.2
Zn content in liver0.00.00.0-0.10.0-0.00.10.10.20.1
Bone: minimum diameter2.34.29.8-2.8-3.12.72.00.6-0.3-0.3
Time in familiar zone, hab. session 10.00.00.20.2-0.0-0.4-0.2-0.1-0.2-0.1
Time in novel zone, hab. session 10.50.50.9-1.0-0.90.6-0.1-0.8-0.6-0.6
Total zone transitions, hab. session 11.01.44.02.01.5-1.6-0.70.30.40.2
Total locomotion distance, hab. session 10.91.33.41.81.5-1.6-0.9-0.10.30.3
Locomotion velocity, hab. session 11.01.43.81.91.6-1.6-0.9-0.00.20.2
Time in familiar zone, hab. session 20.60.61.3-0.6-0.8-0.2-0.4-0.8-1.1-1.0
Time in novel zone, hab. session 20.10.10.30.40.60.0-0.00.10.50.3
Total zone transitions, hab. session 20.91.23.11.61.0-1.8-1.1-0.3-0.5-0.5
Total locomotion distance, hab. session 22.22.96.62.21.7-2.6-1.9-1.0-0.8-0.8
Locomotion velocity, hab. session 22.12.86.22.31.6-2.5-1.9-0.9-0.7-0.7
Novel to familiar place preference ratio0.20.20.50.10.0-0.3-0.6-0.7-0.4-0.4
Novelty place preference0.40.41.1-0.3-0.3-0.1-0.7-1.1-0.8-0.8
Time in novel zone, NPP test0.50.61.3-0.5-0.5-0.0-0.7-1.1-1.0-0.9
Total zone transitions, NPP test0.10.20.40.60.4-0.50.10.50.20.2
Total locomotion distance, NPP test0.40.51.20.90.6-1.1-0.8-0.5-0.4-0.4
Locomotion velocity, NPP test0.50.71.61.10.8-1.3-0.9-0.5-0.3-0.4
Intraocular pressure0.30.40.8-0.70.20.4-0.5-0.9-0.7-0.7
Delta distance traveled before/after self-admin4.75.08.00.30.2-2.0-2.8-2.8-2.8-2.7
Delta ambulatory time before/after self-admin4.25.17.90.40.5-2.1-2.8-2.8-2.8-2.7
Parametrial fat weight2.45.710.3-2.9-3.21.2-0.6-2.3-2.7-2.5
Pavlov. Cond. lever latency0.10.10.3-0.0-0.1-0.2-0.4-0.5-0.5-0.4
Pavlov. Cond. magazine entry latency0.20.30.70.70.8-0.7-0.5-0.20.10.0
Pavlov. Cond. change in total contacts0.00.00.2-0.00.4-0.2-0.2-0.1-0.1-0.0
Pavlov. Cond. index score0.00.00.10.30.3-0.2-0.10.10.20.1
Pavlov. Cond. latency score0.10.10.20.40.4-0.4-0.2-0.00.10.1
Pavlov. Cond. lever contacts0.30.40.80.0-0.00.30.70.90.80.7
Pavlov. Cond. magazine entry number0.10.10.3-0.2-0.30.40.50.40.20.4
Pavlov. Cond. intertrial magazine entries4.95.811.9-2.7-2.33.53.02.01.41.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.10.2-0.1-0.00.10.20.1
Pavlov. Cond. response bias0.10.10.20.30.4-0.10.10.30.50.3
Pavlov. Cond. lever latency0.81.01.91.21.2-1.4-1.2-0.9-0.3-0.4
Pavlov. Cond. magazine entry latency0.20.30.70.30.20.20.50.80.60.7
Pavlov. Cond. change in total contacts0.30.51.1-1.0-1.01.00.60.2-0.2-0.2
Pavlov. Cond. index score0.70.91.7-0.3-0.41.01.21.31.01.1
Pavlov. Cond. latency score0.30.41.00.0-0.00.50.81.00.70.8
Pavlov. Cond. lever contacts0.81.12.1-1.3-1.31.51.20.70.20.2
Pavlov. Cond. magazine entry number0.00.00.00.10.2-0.2-0.0-0.00.20.1
Pavlov. Cond. intertrial magazine entries0.30.40.8-0.6-0.70.70.90.70.50.5
Pavlov. Cond. lever-magazine prob. diff.0.60.81.6-0.2-0.20.91.11.31.01.0
Pavlov. Cond. response bias0.81.12.1-1.1-1.21.51.31.00.40.5
Time in closed arm before self-admin0.20.30.7-0.7-0.80.2-0.0-0.4-0.6-0.5
Time in closed arm after self-admin8.18.715.2-0.7-1.2-1.8-3.3-3.9-3.9-3.8
Time in open arm before self-admin0.10.10.20.30.3-0.4-0.4-0.3-0.2-0.1
Time in open arm after self-admin2.32.64.7-0.6-0.21.62.22.11.71.7
Bone: periosteal estimation0.81.73.7-1.7-1.91.71.40.5-0.1-0.2
Bone: periosteal perimeter0.71.32.6-0.8-1.01.21.61.40.90.7
Bone: post-yield work1.11.62.8-1.2-1.01.71.61.20.91.0
Progressive ratio test 1 active lever presses1.41.73.61.91.9-1.8-1.3-0.3-0.0-0.1
Progressive ratio test 1 breakpoint1.31.63.41.81.8-1.8-1.3-0.3-0.1-0.1
Progressive ratio test 1 inactive lever presses1.21.74.42.11.8-1.3-0.50.60.90.9
Progressive ratio test 2 active lever presses1.92.25.32.31.8-1.3-0.11.11.41.5
Progressive ratio test 2 breakpoint1.92.14.92.21.8-1.2-0.01.11.41.5
Progressive ratio test 2 inactive lever presses2.84.66.92.42.2-0.61.22.62.62.6
Incentive Sensitization - Responses1.11.63.01.20.7-0.10.91.51.71.7
Incentive Sensitization - Breakpoint1.41.93.51.20.7-0.01.01.71.91.9
Sum of active levers in priming session hrs 5-61.71.52.70.1-0.21.01.51.61.61.5
Progressive ratio0.30.41.0-0.7-0.51.00.80.50.50.5
Food seeking constrained by brief footshock0.70.82.01.41.2-1.2-0.7-0.20.40.4
Seeking ratio, punishment vs. effort0.50.71.81.30.7-1.3-0.9-0.5-0.0-0.1
Retroperitoneal fat weight1.25.210.3-3.2-3.11.7-0.0-1.7-2.4-2.3
Reaction time number correct0.20.40.8-0.20.20.50.80.90.70.8
Reaction time mean minus median0.30.71.40.80.80.10.50.91.11.2
Reaction time mean minus median AUC0.51.42.50.20.40.91.31.51.51.6
Reaction time num false alarms1.42.04.52.12.0-1.8-0.90.20.60.7
Reaction time num false alarms AUC1.52.45.32.32.1-2.2-1.4-0.10.20.3
Reaction time trials correct on left0.20.40.8-0.20.20.50.80.90.70.8
Reaction time trials on left0.20.50.9-0.20.10.50.80.90.80.9
Reaction time mean0.10.20.4-0.3-0.40.3-0.3-0.7-0.4-0.4
Reaction time mean AUC0.00.00.1-0.0-0.20.30.2-0.10.20.2
Median of all reaction times0.60.81.7-0.7-0.80.2-0.6-1.3-1.0-1.1
Reaction time omissions0.10.10.20.2-0.1-0.4-0.4-0.4-0.3-0.2
Reaction time false alarm rate1.72.34.82.12.0-2.2-1.6-0.5-0.1-0.1
Reaction time premature initiation rate0.91.32.5-1.5-1.61.0-0.0-0.7-1.1-1.1
Reaction time premature initiations0.40.81.9-1.4-1.31.20.70.2-0.2-0.2
Std. dev. reaction times0.20.50.91.00.8-0.20.10.50.80.9
Reaction time trials completed0.20.50.9-0.20.10.50.80.90.80.9
Reaction time trials AUC0.30.50.9-0.5-0.20.71.00.90.70.8
Run reversals in cocaine runway, females0.30.31.10.61.1-0.4-0.30.20.20.2
Run reversals in cocaine runway, males0.50.51.60.10.30.50.81.30.70.7
Latency to leave start box in cocaine runway0.40.50.8-0.10.1-0.5-0.9-0.9-0.9-0.9
Latency to leave start box in cocaine runway, F1.11.32.30.30.3-1.2-1.5-1.5-1.2-1.2
Latency to leave start box in cocaine runway, M0.20.20.3-0.4-0.40.60.50.50.20.2
Std. dev. time between licks in bursts0.91.22.40.80.70.00.91.51.61.5
Total sessions with >9 infusions0.30.40.80.50.5-0.8-0.9-0.8-0.4-0.4
Short access day 1 total inactive lever presses0.81.02.01.41.1-0.50.10.71.31.2
Short access day 10 total inactive lever presses0.10.30.4-0.2-0.60.60.60.40.50.5
Short access day 1 total infusions0.50.61.50.30.4-0.9-1.2-1.2-0.6-0.5
Short access day 10 total infusions0.60.81.60.30.3-1.0-1.3-1.2-0.8-0.9
Short access total infusions0.60.71.50.40.5-1.0-1.2-1.1-0.7-0.7
Short access day 1 locomotion0.81.02.21.30.8-1.5-1.4-0.9-0.3-0.3
Short access day 10 total locomotion0.10.20.30.1-0.6-0.4-0.4-0.3-0.4-0.5
Short access total locomotion0.20.20.60.50.1-0.8-0.6-0.4-0.3-0.3
One hour access (0.3 mA shock)1.72.03.11.81.7-0.60.61.41.61.6
Compulsive drug intake0.40.51.4-1.2-0.80.60.1-0.5-0.6-0.5
One hour access (shock baseline)2.03.14.82.11.8-0.40.81.92.22.1
Social response proportion0.40.41.60.81.3-0.6-0.70.10.00.1
Social responses0.60.71.31.11.2-1.2-1.1-0.3-0.3-0.2
Social time0.00.00.1-0.20.20.20.20.00.10.0
Soleus weight0.51.43.7-1.7-1.91.30.90.1-0.5-0.5
Bone: stiffness0.20.30.6-0.0-0.20.50.70.80.60.5
Tibialis anterior weight4.515.335.1-5.9-5.94.92.3-0.8-1.8-1.9
Time to tail flick, vehicle, before self-admin0.70.71.80.90.0-0.10.30.71.31.3
Time to tail flick, vehicle, after self-admin0.70.92.2-1.5-1.00.7-0.0-0.7-1.1-1.0
Time to tail flick, test, before self-admin3.03.15.71.41.2-2.2-2.4-1.8-1.5-1.4
Time to tail flick, test, after self-admin1.61.62.90.70.7-1.6-1.7-1.4-1.3-1.3
Delta time to tail flick, vehicle, before/after SA0.90.92.1-1.5-0.60.70.1-0.6-1.2-1.1
Delta time to tail flick, test, before/after SA0.10.10.2-0.2-0.10.30.50.40.30.2
Tibia length0.00.00.10.10.30.0-0.2-0.1-0.0-0.1
Ambulatory time before self-admin1.01.62.9-0.9-0.91.51.71.41.11.0
Ambulatory time after self-admin0.70.81.8-0.6-0.5-0.1-0.7-1.1-1.2-1.3
Bone: tissue strength0.30.30.60.60.7-0.8-0.7-0.3-0.2-0.3
Total heroin consumption0.81.01.51.21.0-0.40.51.21.21.1
Bone: trabecular number0.30.50.8-0.4-0.7-0.2-0.6-0.9-0.9-0.8
Bone: trabecular spacing1.52.05.22.02.3-1.8-1.2-0.20.20.2
Bone: trabecular thickness0.60.71.6-1.3-1.31.10.5-0.1-0.3-0.3
Bone: trabecular tissue density0.91.43.01.51.3-1.7-1.3-0.6-0.3-0.6
Water consumed over 24 hours0.50.61.31.11.0-0.70.00.60.80.8
Number of responses in last shaping day1.92.14.21.61.5-2.1-1.9-1.2-0.7-0.6