Hub : Genes

Shisal2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Shisal2b 0.14 0.08 0.0e+00 0.17 0.06 0.19 0.05 1.9e-18 5.1e-07 1.0e-20 1.4e-06
2 OFC gene expression Shisal2b 0.19 0.16 4.9e-03 0.05 -0 0.04 0 2.5e-02 3.5e-01 3.4e-02 2.6e-01
3 NAcc gene expression Shisal2b 0.02 0.01 5.7e-04 0.02 0.01 0.01 0.01 1.2e-03 3.4e-03 1.0e-02 3.1e-03
4 IL gene expression Shisal2b 0.27 0.18 2.4e-04 0.11 0.1 0.1 0.01 1.4e-03 2.5e-03 2.2e-03 1.6e-01
5 pVTA gene expression Shisal2b 0.03 0.02 6.3e-03 0.01 -0 0.01 0 8.5e-02 6.3e-01 5.9e-02 1.6e-01
6 Brain gene expression Shisal2b 0.03 0.03 1.6e-04 0.03 0.04 0.04 0.05 3.8e-04 5.2e-05 3.0e-04 3.7e-05
7 IC gene expression Shisal2b 0.23 0.16 2.7e-05 0.06 0.09 0.06 0.07 1.2e-03 1.4e-04 1.0e-03 6.4e-04
8 NAcc intron excision ratio chr2_37747664_37752686 0.02 0.02 6.0e-04 0.02 0.01 0.01 0.02 2.8e-04 2.2e-03 3.0e-03 1.2e-03
9 BLA gene expression Shisal2b 0.12 0.07 1.3e-06 0.11 0.08 0.12 0.08 1.9e-06 4.4e-05 1.1e-06 7.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.61.11.8-0.8-1.1-0.9-1.0-1.3-1.2-0.61.3-0.9
Area under the delay curve0.30.31.20.30.20.60.50.00.31.0-0.31.1
BMI with tail2.17.111.0-2.8-2.9-2.6-2.6-3.3-3.1-1.92.6-1.9
BMI without tail0.51.53.5-1.2-1.4-1.1-1.2-1.9-1.6-0.51.0-0.4
Body weight3.716.023.94.03.94.44.12.93.54.9-3.74.3
Weight adjusted by age0.10.10.50.40.30.20.2-0.00.10.50.00.7
Bone surface0.00.00.20.4-0.00.10.10.1-0.00.10.10.4
Bone volume0.00.00.10.1-0.3-0.2-0.2-0.2-0.3-0.10.40.1
Breakpoint value in progressive ratio session2.93.54.4-2.1-1.7-1.8-1.7-2.1-1.9-1.51.9-1.9
Number of licking bursts1.93.14.0-2.0-1.8-1.9-1.9-1.6-1.8-2.01.6-1.1
Context. condit. distance diff. score1.82.22.61.61.61.61.51.51.51.6-1.31.2
Locomotion velocity, session 10.50.50.70.80.70.60.80.60.80.8-0.60.6
Locomotion distance, session 10.70.81.00.90.81.01.00.91.00.9-1.00.6
Locomotion velocity, session 24.24.96.02.42.22.22.31.92.22.4-1.72.5
Locomotion distance, session 20.81.11.51.11.01.01.10.91.11.2-1.20.8
Locomotion velocity, session 35.25.97.12.52.62.52.62.42.52.7-2.21.7
Locomotion distance, session 37.48.19.62.92.92.93.03.02.92.7-3.12.0
Stereotopy head waving bouts, day 30.20.20.40.40.30.50.40.20.40.6-0.60.2
Stereotopy head waving duration, day 30.10.10.3-0.2-0.2-0.1-0.2-0.5-0.20.10.2-0.4
Locomotion velocity, session 70.10.10.10.40.30.30.20.40.20.1-0.10.2
Locomotion distance, session 70.30.40.70.80.70.60.60.80.60.5-0.70.6
Stereotopy head waving bouts, day 70.00.00.10.1-0.10.00.1-0.2-0.00.20.20.1
Stereotopy head waving duration, day 70.10.10.20.20.20.40.3-0.00.20.5-0.00.2
Locomotion velocity, session 82.42.94.21.71.81.71.81.41.82.1-1.61.2
Locomotion distance, session 84.56.67.52.72.62.62.62.52.62.7-2.52.1
Degree of sensitization distance4.04.24.8-2.0-2.2-2.2-2.2-2.0-2.1-2.12.2-1.4
Degree of sensitization stereotypy0.00.00.1-0.0-0.1-0.10.0-0.2-0.10.10.30.1
Conditioned locomotion0.00.00.20.1-0.00.00.10.40.2-0.30.0-0.3
Cocaine response after cond. corrected1.51.93.51.41.31.41.41.91.50.8-1.50.6
Cocaine response after cond. not corrected2.02.43.71.51.61.71.61.91.71.2-1.60.9
Cocaine response before conditioning0.20.30.80.30.60.60.60.20.40.9-0.30.5
Saline control response1.52.02.71.51.51.21.41.21.31.5-1.31.7
Bone: connectivity density0.10.20.50.0-0.3-0.3-0.2-0.7-0.50.30.6-0.1
Bone: cortical apparent density0.00.10.3-0.00.0-0.00.00.1-0.00.1-0.6-0.5
Bone: cortical area0.10.20.50.40.40.50.50.20.20.7-0.40.5
Bone: cortical porosity2.32.54.0-1.7-1.5-1.5-1.5-1.2-1.3-1.82.0-1.4
Bone: cortical porosity2.22.43.6-1.6-1.5-1.5-1.5-1.4-1.4-1.71.9-1.4
Bone: cortical thickness0.10.10.40.10.10.30.3-0.3-0.10.6-0.30.3
Bone: cortical thickness1.21.42.01.11.21.21.31.00.91.4-1.21.3
Bone: cortical tissue density0.10.10.40.00.10.00.00.10.00.1-0.6-0.4
Condit. Reinf. active minus inactive responses2.12.43.3-1.6-1.5-1.5-1.6-1.8-1.7-1.31.3-1.5
Condit. Reinf. active-inactive response ratio2.02.22.8-1.5-1.6-1.5-1.6-1.7-1.6-1.31.0-1.3
Condit. Reinf. active responses0.30.40.7-0.6-0.5-0.7-0.7-0.8-0.7-0.40.5-0.6
Condit. Reinf. inactive responses1.21.42.01.31.41.11.21.11.21.4-0.91.0
Incentive salience index mean1.31.62.3-1.4-1.3-1.3-1.4-1.5-1.5-1.11.0-0.9
Condit. Reinf. lever presses0.20.20.3-0.5-0.5-0.5-0.6-0.5-0.5-0.50.30.0
Condit. Reinf. active minus inactive responses4.55.86.92.42.62.52.62.32.52.6-2.41.6
Condit. Reinf. active-inactive response ratio2.12.43.01.31.61.71.71.71.71.5-1.70.7
Condit. Reinf. active responses1.72.43.31.61.61.51.61.31.51.8-1.61.2
Condit. Reinf. inactive responses0.30.41.30.70.40.20.40.10.30.8-0.51.2
Condit. Reinf. lever presses1.72.33.31.51.71.61.61.31.51.8-1.60.8
Condit. Reinf. lever reinforcers received2.33.14.11.81.91.71.91.61.82.0-1.81.4
Conditioned reinforcement - actives2.03.44.91.92.21.71.81.91.61.7-1.91.9
Conditioned reinforcement - inactives0.60.91.61.11.01.00.81.31.00.6-0.90.7
Conditioned locomotion0.81.01.51.01.20.91.11.20.90.9-1.20.2
Patch foraging indifference point 0 sec3.36.08.72.72.42.62.32.22.32.6-2.92.0
Patch foraging indifference point AUC0.20.30.7-0.4-0.5-0.8-0.4-0.7-0.6-0.20.20.5
Delay disc. indifference point, 0s delay0.50.50.9-0.9-0.8-0.7-0.6-0.5-0.7-0.71.00.3
Delay disc. indifference point, 16s delay1.11.21.91.10.91.11.10.91.01.4-1.31.1
Delay disc. indifference point, 2s delay0.20.30.6-0.5-0.8-0.4-0.5-0.7-0.6-0.20.3-0.1
Delay disc. indifference point, 24s delay0.80.91.20.90.71.01.00.90.91.1-1.11.0
Delay disc. indifference point, 4s delay0.20.20.5-0.4-0.3-0.1-0.1-0.2-0.30.10.70.7
Delay disc. indifference point, 8s delay0.20.20.80.0-0.30.30.3-0.5-0.00.9-0.10.6
Indifference point function ln k2.54.46.02.22.22.32.12.52.31.8-2.21.1
Indifference point function log k2.54.46.02.22.22.32.12.52.31.8-2.21.1
Patch foraging total patch changes 0 sec3.97.410.12.92.62.82.72.52.62.8-3.22.2
Patch foraging total patch changes 12 sec0.20.21.00.4-0.10.1-0.0-0.1-0.00.3-0.91.0
Patch foraging total patch changes 18 sec0.10.20.90.3-0.10.0-0.0-0.2-0.10.4-0.80.9
Patch foraging total patch changes 24 sec0.81.33.01.20.91.11.01.31.00.8-1.71.0
Patch foraging total patch changes 6 sec0.81.32.71.20.81.00.90.50.71.4-1.51.6
Patch foraging time to switch 0 sec4.38.810.3-3.1-3.2-2.9-3.2-2.8-2.9-3.22.7-2.8
Patch foraging water rate 0 sec3.36.97.72.72.62.72.72.42.62.8-2.42.8
Patch foraging water rate 12 sec3.06.48.82.52.62.92.63.02.72.1-2.31.6
Patch foraging water rate 18 sec4.77.39.02.72.83.02.92.72.82.6-2.42.3
Patch foraging water rate 24 sec2.73.84.42.02.02.12.01.82.02.0-1.52.1
Patch foraging water rate 6 sec12.217.720.14.34.34.54.44.34.44.1-3.93.5
Seeking ratio, delayed vs. immediate footshock0.81.01.9-0.9-0.9-1.1-1.1-1.4-1.2-0.61.1-0.8
Distance traveled before self-admin0.81.13.31.00.81.10.90.91.00.9-0.51.8
Distance traveled after self-admin1.41.72.21.51.01.41.41.21.41.4-1.11.5
Extensor digitorum longus weight3.714.521.7-3.9-3.9-3.9-3.8-4.7-4.3-2.84.0-2.5
Bone: elastic displacement1.92.23.0-1.6-1.6-1.5-1.5-1.3-1.3-1.71.7-1.1
Bone: elastic work0.50.71.1-0.9-1.0-0.8-0.8-0.6-0.7-1.00.9-0.4
Bone: endosteal estimation0.51.12.11.21.01.00.91.41.20.5-0.91.0
Bone: endosteal perimeter0.00.10.20.50.20.20.20.30.20.2-0.10.3
Epididymis fat weight0.82.85.61.71.61.81.80.81.42.4-1.22.0
Delta time in closed arm before/after self-admin3.23.03.7-1.7-1.7-1.8-1.7-1.9-1.8-1.41.9-1.7
Delta time in open arm before/after self-admin0.20.20.4-0.4-0.4-0.3-0.5-0.4-0.4-0.50.7-0.2
Diff in mean of infusions in LGA sessions0.10.10.30.20.30.20.10.10.10.3-0.60.4
Delay discount exponential model param0.30.41.2-0.3-0.2-0.6-0.5-0.0-0.3-1.00.3-1.1
Extinction: sum of active levers before priming2.62.93.9-2.0-1.6-1.7-1.7-1.8-1.7-1.71.8-1.2
Active lever presses in extinction session 62.62.63.8-1.5-1.3-1.7-1.5-1.3-1.6-1.71.8-1.9
Bone: final force0.50.71.10.80.90.80.80.90.80.7-0.91.0
Bone: final moment0.71.11.31.01.11.01.01.21.00.8-1.11.1
Food consumed during 24 hour testing period0.71.01.50.81.01.01.01.11.10.8-1.01.2
Glucose0.40.61.6-0.9-0.9-0.8-0.8-0.4-0.6-1.20.3-0.7
Heart weight0.61.01.51.00.91.00.81.01.00.8-1.21.0
Delay discount hyperbolic model param0.30.31.2-0.2-0.1-0.5-0.50.0-0.2-1.00.3-1.1
Intermittent access intake day 1-15 change0.00.00.0-0.10.0-0.0-0.20.2-0.0-0.20.1-0.1
Intermittent access intake escalation0.10.10.40.30.40.30.10.60.40.1-0.30.1
Intermittent access intake escalation 20.20.20.3-0.5-0.2-0.3-0.6-0.3-0.4-0.30.6-0.4
Intermitt. access day 1 inactive lever presses0.41.62.0-1.2-1.1-1.3-1.4-1.2-1.4-1.21.1-1.3
Intermitt. access day 15 inactive lever presses0.71.42.6-1.2-1.2-1.2-1.1-0.9-1.1-1.30.9-1.6
Intermitt. access escalation Index0.40.60.80.80.80.90.90.60.80.8-0.80.5
Intermittent access day 1 total infusions1.52.33.01.71.71.21.41.71.51.2-1.51.7
Intermittent access day 15 total infusions2.23.35.01.92.01.61.62.21.81.3-1.81.7
Intermittent access terminal intake (last 3 days)1.51.92.91.51.71.11.21.71.41.1-1.21.5
Intermittent access total infusions3.33.95.32.12.21.81.82.32.01.6-1.92.0
Intermittent access day 1 locomotion2.43.15.11.92.11.71.82.31.81.3-1.71.0
Intermittent access day 15 total locomotion2.03.76.12.02.31.71.82.52.01.4-2.11.2
Intermittent access total locomotion4.95.99.12.52.82.32.33.02.52.0-2.41.7
Intermittent access standard deviation0.10.10.4-0.2-0.2-0.3-0.30.60.1-0.60.2-0.1
Left kidney weight2.611.914.53.63.43.63.53.03.33.8-3.53.3
Right kidney weight2.511.514.43.53.43.43.42.73.13.8-3.53.5
Cocaine induced anxiety0.71.02.01.01.01.01.01.01.10.8-0.51.4
Post-drug Anxiety0.60.61.90.80.70.70.70.70.80.6-0.41.4
Baseline Anxiety0.10.20.5-0.3-0.4-0.4-0.4-0.7-0.6-0.00.10.0
Tail length9.537.040.46.36.06.46.15.66.06.1-5.96.2
Length with tail14.864.373.58.38.28.58.27.27.88.6-7.57.8
Length without tail10.634.241.96.06.16.26.15.15.76.5-5.35.5
Times rat made contact with spout0.40.51.3-0.8-0.7-0.7-0.6-0.2-0.5-1.10.9-0.5
Lifetime Intake2.73.23.91.91.91.61.72.01.81.5-1.81.9
Liver weight, left4.27.08.92.72.72.82.72.32.53.0-2.82.3
Liver weight, right0.00.10.30.30.00.10.1-0.30.00.6-0.4-0.3
Locomotor activity0.30.50.80.80.90.60.90.80.70.5-0.40.8
Locomotor testing distance0.20.30.6-0.5-0.4-0.6-0.5-0.5-0.6-0.60.8-0.2
Locomotor testing rearing0.10.20.8-0.3-0.3-0.5-0.4-0.0-0.3-0.90.70.4
Locomotion in novel chamber0.50.61.6-0.6-1.0-0.7-1.0-0.4-0.5-1.20.7-0.2
Locomotion in novel chamber post-restriction0.00.10.4-0.2-0.2-0.2-0.3-0.20.00.0-0.2-0.7
Fecal boli incidents, locomotor time 10.91.31.7-1.1-0.9-1.3-1.2-1.0-1.0-1.31.1-1.1
Change in fecal boli incidents, locomotor task0.10.10.20.1-0.4-0.1-0.3-0.2-0.4-0.1-0.40.4
Time >=10cm from walls, locomotor time 12.12.33.0-1.7-1.5-1.5-1.7-1.3-1.7-1.71.3-0.9
Bouts of movement, locomotor time 10.30.30.9-0.5-0.4-0.6-0.6-0.1-0.4-0.90.7-0.4
Total resting periods, locomotor time 10.00.00.20.00.0-0.2-0.10.30.1-0.50.20.0
Rest time, locomotor task time 10.70.82.3-0.8-0.7-0.9-0.8-0.3-0.6-1.10.9-1.5
Distance moved, locomotor task time 10.81.32.41.10.91.21.00.80.81.3-1.21.6
Vertical activity count, locomotor time 10.40.92.10.90.61.00.80.70.90.9-1.01.5
Time >=10cm from walls, locomotor time 20.81.21.9-1.1-1.3-1.2-1.3-1.3-1.4-0.90.6-0.3
Bouts of movement, locomotor time 20.10.20.50.10.50.50.50.30.30.6-0.70.4
Total resting periods, locomotor time 20.00.00.1-0.30.1-0.00.1-0.1-0.10.1-0.3-0.2
Rest time, locomotor task time 22.73.55.7-1.9-1.6-1.9-1.7-1.3-1.4-2.32.0-2.4
Distance moved, locomotor task time 21.41.73.01.21.01.41.20.80.81.7-1.51.6
Vertical activity count, locomotor time 20.10.10.40.30.10.40.30.20.30.4-0.40.7
Light reinforcement 11.74.25.62.42.22.02.22.12.02.0-1.91.7
Light reinforcement 20.20.31.7-0.4-0.1-0.5-0.2-0.1-0.5-0.60.7-1.3
Bone: marrow area0.51.12.11.21.01.00.91.41.20.5-0.80.9
Bone: maximum diameter0.20.40.7-0.5-0.5-0.5-0.5-0.7-0.8-0.30.5-0.9
Bone: maximum force0.10.20.30.40.50.50.40.40.40.5-0.50.5
Bone: maximum moment0.30.50.60.70.70.80.70.70.60.7-0.80.7
Mean time between licks in bursts0.20.51.3-0.8-0.7-0.6-0.6-0.7-0.7-0.30.7-1.1
Mean num. licks in bursts1.31.92.41.61.41.51.51.51.51.3-1.10.9
Cd content in liver1.61.83.41.21.31.31.30.71.01.7-1.51.8
Co content in liver0.00.00.1-0.2-0.1-0.1-0.1-0.3-0.20.10.20.2
Cu content in liver0.00.00.20.10.10.20.10.20.20.1-0.20.4
Fe content in liver1.21.41.61.21.31.21.21.11.11.2-1.11.2
K content in liver1.81.73.21.31.51.31.31.81.50.9-1.10.7
Mg content in liver0.10.10.40.30.30.20.30.70.4-0.1-0.2-0.3
Mn content in liver0.40.50.70.80.80.70.80.80.80.6-0.40.5
Na content in liver0.10.10.7-0.0-0.1-0.1-0.10.10.0-0.20.1-0.9
Rb content in liver1.21.51.91.21.31.31.41.11.21.4-1.00.7
Se content in liver0.60.71.2-0.8-0.9-0.9-1.0-1.1-1.0-0.70.8-0.2
Sr content in liver2.32.02.5-1.4-1.4-1.4-1.4-1.4-1.4-1.31.6-1.5
Zn content in liver0.20.20.40.50.40.50.40.50.50.3-0.70.6
Bone: minimum diameter2.54.55.42.22.02.22.12.32.11.8-2.12.2
Time in familiar zone, hab. session 14.14.04.42.12.12.02.12.02.12.1-1.91.5
Time in novel zone, hab. session 16.16.17.3-2.5-2.5-2.5-2.5-2.7-2.6-2.42.4-2.0
Total zone transitions, hab. session 10.00.10.30.20.10.20.1-0.3-0.00.5-0.30.1
Total locomotion distance, hab. session 10.20.30.80.40.50.50.60.60.60.4-0.9-0.4
Locomotion velocity, hab. session 10.20.30.70.40.50.50.60.60.60.4-0.8-0.1
Time in familiar zone, hab. session 21.92.02.91.61.51.41.51.71.51.2-1.21.0
Time in novel zone, hab. session 22.42.53.6-1.8-1.6-1.6-1.6-1.9-1.7-1.31.4-1.3
Total zone transitions, hab. session 20.10.20.40.30.30.40.40.50.50.4-0.6-0.1
Total locomotion distance, hab. session 20.10.10.7-0.10.10.20.20.30.3-0.1-0.5-0.8
Locomotion velocity, hab. session 20.20.30.80.30.40.50.50.70.60.2-0.9-0.4
Novel to familiar place preference ratio2.32.63.8-1.6-1.7-1.6-1.7-2.0-1.7-1.31.6-1.0
Novelty place preference1.81.93.3-1.4-1.4-1.4-1.5-1.8-1.5-1.01.4-0.7
Time in novel zone, NPP test1.92.13.5-1.4-1.5-1.5-1.5-1.9-1.6-1.11.5-0.8
Total zone transitions, NPP test1.31.93.01.31.41.51.51.41.51.5-1.70.4
Total locomotion distance, NPP test0.30.41.00.30.60.60.70.60.60.6-1.0-0.4
Locomotion velocity, NPP test0.91.22.40.91.11.11.21.21.20.9-1.60.0
Intraocular pressure4.05.78.6-2.5-2.2-2.4-2.3-2.9-2.5-1.62.9-1.6
Delta distance traveled before/after self-admin1.11.22.11.31.01.01.21.01.01.1-1.40.6
Delta ambulatory time before/after self-admin1.11.32.61.41.01.01.21.11.11.1-1.60.6
Parametrial fat weight0.10.10.50.20.10.10.1-0.4-0.20.70.30.7
Pavlov. Cond. lever latency0.10.10.5-0.1-0.2-0.2-0.1-0.1-0.1-0.20.4-0.7
Pavlov. Cond. magazine entry latency2.12.73.91.51.61.61.51.21.41.9-2.01.7
Pavlov. Cond. change in total contacts3.53.74.91.82.01.91.91.61.82.2-1.92.2
Pavlov. Cond. index score0.91.12.20.91.01.00.90.70.91.1-1.51.4
Pavlov. Cond. latency score0.40.51.20.50.60.60.50.40.50.7-1.11.1
Pavlov. Cond. lever contacts0.81.01.60.91.01.00.90.80.91.0-1.21.3
Pavlov. Cond. magazine entry number3.34.25.7-2.0-2.0-2.1-2.0-1.7-1.9-2.32.4-2.1
Pavlov. Cond. intertrial magazine entries6.47.710.8-2.9-2.6-2.7-2.6-3.3-3.0-2.03.1-2.7
Pavlov. Cond. lever-magazine prob. diff.1.11.42.31.01.11.11.00.81.01.2-1.51.5
Pavlov. Cond. response bias3.03.74.51.92.01.91.91.61.82.1-2.12.1
Pavlov. Cond. lever latency2.43.23.9-1.9-1.9-1.9-1.9-1.6-1.7-2.01.9-1.3
Pavlov. Cond. magazine entry latency1.11.41.61.31.21.21.21.31.21.1-1.11.0
Pavlov. Cond. change in total contacts4.36.88.52.82.72.72.62.62.62.6-2.91.9
Pavlov. Cond. index score2.53.33.61.91.91.91.91.81.81.9-1.81.5
Pavlov. Cond. latency score2.43.23.61.91.91.91.91.81.81.8-1.81.4
Pavlov. Cond. lever contacts1.82.43.11.71.71.61.61.41.51.8-1.61.2
Pavlov. Cond. magazine entry number2.32.83.3-1.8-1.7-1.7-1.8-1.8-1.8-1.61.6-1.1
Pavlov. Cond. intertrial magazine entries0.00.10.20.10.30.10.2-0.10.10.4-0.10.5
Pavlov. Cond. lever-magazine prob. diff.2.63.43.82.01.91.91.91.81.81.9-1.91.4
Pavlov. Cond. response bias1.52.02.61.51.51.51.51.31.41.6-1.51.0
Time in closed arm before self-admin0.30.40.80.70.60.50.60.90.60.3-0.50.8
Time in closed arm after self-admin0.00.00.00.20.0-0.20.00.20.1-0.1-0.00.1
Time in open arm before self-admin0.10.10.50.10.20.40.2-0.20.00.7-0.30.2
Time in open arm after self-admin0.91.01.5-1.2-0.8-0.9-1.0-1.1-1.0-0.81.1-0.9
Bone: periosteal estimation0.30.70.90.90.80.80.80.90.80.6-0.70.9
Bone: periosteal perimeter0.20.30.50.60.50.50.50.20.30.7-0.60.6
Bone: post-yield work0.20.31.10.40.50.50.5-0.00.21.1-0.50.1
Progressive ratio test 1 active lever presses2.32.93.71.91.81.51.51.91.61.2-1.91.8
Progressive ratio test 1 breakpoint2.63.13.91.91.81.61.52.01.71.4-2.01.9
Progressive ratio test 1 inactive lever presses0.70.92.41.00.81.00.70.90.80.9-0.71.6
Progressive ratio test 2 active lever presses2.73.14.31.82.11.61.62.11.71.4-1.42.0
Progressive ratio test 2 breakpoint2.93.34.61.92.11.71.62.11.81.4-1.52.1
Progressive ratio test 2 inactive lever presses0.61.01.51.11.20.90.91.20.90.8-0.81.2
Incentive Sensitization - Responses2.63.74.91.92.21.92.02.01.91.8-1.32.1
Incentive Sensitization - Breakpoint2.33.04.31.72.01.71.81.81.71.6-1.22.1
Sum of active levers in priming session hrs 5-62.01.82.5-1.6-1.0-1.5-1.1-1.2-1.4-1.31.4-1.5
Progressive ratio0.10.20.90.20.50.10.3-0.3-0.10.9-0.5-0.5
Food seeking constrained by brief footshock2.42.94.01.71.71.81.72.01.91.4-1.81.3
Seeking ratio, punishment vs. effort0.81.12.70.90.71.10.91.61.40.1-0.61.4
Retroperitoneal fat weight0.10.52.00.70.30.60.6-0.20.21.10.11.4
Reaction time number correct6.612.715.23.73.93.63.83.83.73.5-3.12.8
Reaction time mean minus median0.00.10.40.10.10.10.20.20.10.2-0.50.7
Reaction time mean minus median AUC0.10.30.50.40.60.50.70.70.60.4-0.50.4
Reaction time num false alarms0.50.71.0-1.0-0.8-0.8-0.8-0.9-1.0-0.50.9-0.7
Reaction time num false alarms AUC0.91.52.0-1.4-1.1-1.2-1.1-1.2-1.4-0.91.2-1.2
Reaction time trials correct on left6.612.715.23.73.93.63.83.83.73.5-3.12.8
Reaction time trials on left6.812.715.43.73.93.63.83.83.73.5-3.12.8
Reaction time mean1.72.73.0-1.7-1.7-1.6-1.6-1.7-1.7-1.41.7-1.7
Reaction time mean AUC1.52.32.8-1.7-1.6-1.5-1.5-1.5-1.5-1.31.6-1.6
Median of all reaction times3.24.65.6-2.2-2.1-2.1-2.1-2.2-2.1-1.72.3-2.4
Reaction time omissions0.20.30.60.40.80.50.60.70.50.4-0.1-0.2
Reaction time false alarm rate6.08.39.9-3.1-3.0-2.9-2.9-3.1-3.1-2.52.7-2.5
Reaction time premature initiation rate3.64.97.02.22.42.32.32.72.51.8-2.21.4
Reaction time premature initiations8.715.619.44.04.24.04.14.44.33.6-3.72.9
Std. dev. reaction times0.10.20.3-0.6-0.6-0.5-0.5-0.4-0.5-0.40.4-0.4
Reaction time trials completed6.812.715.43.73.93.63.83.83.73.5-3.12.8
Reaction time trials AUC6.111.613.93.63.73.43.63.63.53.3-2.92.8
Run reversals in cocaine runway, females0.60.61.0-0.8-0.7-0.6-0.6-1.0-0.9-0.31.0-0.7
Run reversals in cocaine runway, males0.10.10.20.40.30.20.50.10.40.5-0.00.0
Latency to leave start box in cocaine runway2.12.43.0-1.7-1.6-1.6-1.5-1.5-1.3-1.41.6-1.7
Latency to leave start box in cocaine runway, F0.20.30.5-0.6-0.6-0.6-0.5-0.4-0.2-0.60.4-0.7
Latency to leave start box in cocaine runway, M2.12.02.7-1.4-1.5-1.4-1.3-1.4-1.4-1.21.6-1.4
Std. dev. time between licks in bursts0.60.71.5-0.8-0.9-0.9-0.8-0.6-0.8-1.00.6-1.2
Total sessions with >9 infusions0.80.91.11.01.00.90.90.90.90.7-1.11.1
Short access day 1 total inactive lever presses0.91.23.21.00.91.10.90.70.91.1-1.21.8
Short access day 10 total inactive lever presses0.10.31.1-0.6-0.3-0.4-0.5-0.4-0.6-0.41.0-0.3
Short access day 1 total infusions0.30.50.70.80.70.60.60.60.60.4-0.90.9
Short access day 10 total infusions1.52.02.61.51.61.21.41.51.41.3-1.41.3
Short access total infusions1.21.52.71.31.21.11.21.11.11.0-1.31.7
Short access day 1 locomotion0.10.10.40.40.60.30.50.30.30.4-0.2-0.1
Short access day 10 total locomotion0.40.82.3-0.8-0.4-0.9-0.7-0.3-0.7-1.01.1-1.5
Short access total locomotion0.40.51.00.70.90.60.81.00.80.4-0.60.2
One hour access (0.3 mA shock)2.62.94.31.92.11.41.61.51.41.8-1.62.1
Compulsive drug intake1.51.82.6-1.4-1.1-1.3-1.2-1.5-1.6-1.11.6-0.8
One hour access (shock baseline)3.35.16.22.42.42.12.22.52.42.0-2.42.0
Social response proportion0.20.21.3-0.3-0.2-0.2-0.0-0.3-0.4-0.10.4-1.1
Social responses1.51.92.51.51.51.21.61.11.11.5-1.51.2
Social time0.00.00.1-0.00.0-0.20.10.0-0.1-0.1-0.2-0.4
Soleus weight0.30.91.8-0.8-0.9-0.9-0.9-1.2-1.1-0.41.3-0.6
Bone: stiffness0.30.51.00.60.70.70.60.50.50.8-1.00.6
Tibialis anterior weight2.48.210.8-2.9-3.0-2.9-3.0-3.3-3.1-2.32.9-1.9
Time to tail flick, vehicle, before self-admin1.61.72.51.41.31.31.51.61.41.0-1.5-0.0
Time to tail flick, vehicle, after self-admin0.10.11.2-0.00.00.20.00.00.1-0.00.21.1
Time to tail flick, test, before self-admin0.20.20.5-0.6-0.4-0.4-0.4-0.3-0.4-0.70.4-0.3
Time to tail flick, test, after self-admin1.41.52.1-1.3-1.4-1.3-1.1-1.0-1.0-1.50.8-1.3
Delta time to tail flick, vehicle, before/after SA1.11.01.9-1.2-1.0-0.8-1.1-1.2-1.0-0.81.40.3
Delta time to tail flick, test, before/after SA0.00.00.10.1-0.1-0.10.00.00.20.1-0.2-0.3
Tibia length5.916.318.54.24.24.24.24.34.23.9-4.22.5
Ambulatory time before self-admin0.10.20.50.30.30.50.40.30.40.40.10.7
Ambulatory time after self-admin1.11.21.61.30.91.21.11.01.11.2-1.01.2
Bone: tissue strength0.80.91.3-1.0-0.9-0.9-0.9-0.9-0.8-0.90.9-1.1
Total heroin consumption1.21.42.1-1.2-1.2-1.2-1.3-1.0-1.1-1.40.9-1.4
Bone: trabecular number0.10.10.30.2-0.00.10.0-0.4-0.20.50.5-0.1
Bone: trabecular spacing0.10.20.7-0.4-0.4-0.5-0.5-0.0-0.2-0.80.20.2
Bone: trabecular thickness0.60.81.2-0.9-0.8-0.8-0.8-1.0-1.1-0.61.1-1.0
Bone: trabecular tissue density2.84.26.8-2.2-1.9-1.9-1.9-1.5-1.8-2.22.1-2.6
Water consumed over 24 hours0.50.71.3-0.9-0.8-0.9-0.8-0.5-0.7-1.21.0-0.3
Number of responses in last shaping day0.60.71.1-0.6-0.9-0.9-1.0-0.7-0.7-1.00.7-0.5