Hub : Genes

Shisal1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Shisal1 0.17 0.07 0.0e+00 0.14 0.2 0.19 0.18 1.2e-15 1.8e-21 4.3e-20 7.3e-20
2 BLA mRNA stability Shisal1 0.29 0.13 4.8e-13 0.18 0.18 0.18 0.18 5.6e-10 6.3e-10 8.6e-10 3.9e-10
3 NAcc mRNA stability Shisal1 0.08 0.05 4.7e-10 0.09 0.09 0.09 0.09 5.7e-11 2.1e-10 1.9e-10 1.1e-10
4 PL intron excision ratio chr7_115550102_115575049 0.04 0.03 3.2e-04 0.03 0.03 0.03 0.03 1.8e-04 6.1e-04 2.7e-04 4.3e-04
5 Brain gene expression Shisal1 0.29 0.09 0.0e+00 0.17 0.22 0.22 0.22 1.7e-15 1.4e-20 2.7e-20 5.1e-20
6 NAcc gene expression Shisal1 0.03 0.02 1.2e-05 0.04 0.03 0.03 0.04 7.6e-06 1.8e-04 1.4e-04 2.8e-05
7 IL mRNA stability Shisal1 0.22 0.13 7.4e-03 0.01 0.03 0.03 0.03 1.8e-01 7.1e-02 8.4e-02 7.3e-02
8 Brain mRNA stability Shisal1 0.15 0.07 2.4e-10 0.1 0.08 0.11 0.1 3.5e-09 3.9e-08 4.8e-10 5.3e-10
9 LHb gene expression Shisal1 0.26 0.14 9.8e-05 0.1 0.16 0.14 0.17 2.3e-03 1.0e-04 2.6e-04 9.2e-05
10 pVTA gene expression Shisal1 0.13 0.08 3.6e-03 0.06 0.07 0.06 0.06 1.0e-03 3.8e-04 1.9e-03 1.5e-03
11 PL gene expression Shisal1 0.15 0.08 8.3e-12 0.11 0.1 0.09 0.1 8.0e-12 3.6e-11 4.9e-10 3.5e-11
12 Liver gene expression Shisal1 0.41 0.13 0.0e+00 0.34 0.28 0.34 0.34 1.9e-39 5.0e-31 1.9e-38 4.6e-39
13 BLA gene expression Shisal1 0.42 0.17 3.2e-10 0.08 0.17 0.15 0.17 4.1e-05 1.8e-09 1.4e-08 2.6e-09
14 IL gene expression Shisal1 0.44 0.22 9.9e-03 -0.01 0.04 -0 0.01 6.2e-01 4.0e-02 3.9e-01 2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.30.8-0.6-0.60.70.70.2-0.9-0.60.7-0.70.3-0.40.30.1-0.5
Area under the delay curve2.22.34.0-2.0-1.81.61.61.9-1.3-1.92.0-0.91.7-1.60.21.00.6
BMI with tail1.13.67.71.92.5-2.5-2.5-1.82.81.2-0.82.6-0.61.0-2.10.41.5
BMI without tail1.53.05.42.22.0-1.5-1.5-1.91.82.3-1.90.3-2.02.20.6-1.8-0.8
Body weight0.72.84.92.22.2-2.1-2.1-1.81.81.9-1.71.7-1.41.5-1.0-0.60.3
Weight adjusted by age0.70.81.31.10.8-0.9-0.9-1.01.01.2-1.20.2-0.91.10.1-0.9-0.4
Bone surface0.00.10.2-0.3-0.20.10.1-0.1-0.4-0.40.4-0.10.2-0.3-0.10.2-0.1
Bone volume0.00.10.2-0.2-0.10.20.2-0.3-0.3-0.30.3-0.30.0-0.2-0.00.1-0.4
Breakpoint value in progressive ratio session0.20.20.40.50.6-0.5-0.5-0.60.50.5-0.10.2-0.50.6-0.1-0.3-0.3
Number of licking bursts0.50.61.7-0.5-1.01.21.20.7-1.00.00.0-0.9-0.20.01.3-0.8-0.7
Context. condit. distance diff. score2.32.84.92.02.0-2.1-2.1-1.72.21.5-1.52.2-1.11.1-1.3-0.10.9
Locomotion velocity, session 11.41.52.91.41.7-1.7-1.7-1.51.40.9-1.01.4-0.80.7-1.20.30.0
Locomotion distance, session 10.10.10.3-0.3-0.20.10.10.2-0.3-0.40.20.20.3-0.5-0.30.60.0
Locomotion velocity, session 23.74.36.82.62.5-2.2-2.2-2.62.02.5-2.30.8-2.42.4-0.2-1.5-1.1
Locomotion distance, session 20.20.30.9-0.6-0.30.10.10.5-0.2-0.90.80.10.8-0.8-0.60.90.4
Locomotion velocity, session 32.42.84.52.11.9-1.6-1.6-2.11.52.1-2.10.7-2.01.9-0.0-1.2-1.0
Locomotion distance, session 30.80.92.30.5-0.00.40.4-0.4-0.31.0-1.0-1.1-1.11.01.4-1.5-1.5
Stereotopy head waving bouts, day 31.72.04.11.52.0-2.0-2.0-1.82.00.9-0.71.5-0.70.9-1.30.20.2
Stereotopy head waving duration, day 33.44.17.32.42.7-2.7-2.7-2.52.51.8-1.62.2-1.51.6-1.5-0.10.3
Locomotion velocity, session 70.50.61.30.90.7-0.4-0.4-0.50.91.1-1.1-0.1-0.90.90.4-0.8-0.4
Locomotion distance, session 70.10.10.3-0.4-0.40.40.40.4-0.1-0.20.3-0.60.2-0.10.3-0.0-0.2
Stereotopy head waving bouts, day 75.05.69.43.12.8-2.6-2.6-2.82.52.8-2.91.7-2.62.4-0.6-1.3-0.7
Stereotopy head waving duration, day 72.73.35.62.42.0-1.7-1.7-2.11.62.4-2.31.0-2.22.10.1-1.4-0.8
Locomotion velocity, session 86.27.413.43.23.5-3.7-3.7-3.03.52.4-2.53.0-1.91.8-2.30.00.7
Locomotion distance, session 81.32.03.51.71.7-1.8-1.8-1.61.91.4-1.51.4-1.11.1-0.9-0.30.2
Degree of sensitization distance1.31.33.5-0.10.5-0.9-0.90.11.0-0.81.01.51.1-0.9-1.91.61.8
Degree of sensitization stereotypy2.83.05.42.31.9-1.7-1.7-2.01.42.3-2.31.0-2.11.9-0.0-1.3-0.6
Conditioned locomotion0.40.51.1-0.6-0.91.01.00.9-1.0-0.20.3-0.80.2-0.31.0-0.30.1
Cocaine response after cond. corrected0.40.41.00.4-0.10.30.3-0.2-0.30.7-0.7-0.6-0.90.61.0-1.0-0.9
Cocaine response after cond. not corrected0.91.02.30.7-0.00.50.5-0.5-0.31.2-1.2-0.8-1.41.01.5-1.5-1.4
Cocaine response before conditioning0.10.10.5-0.3-0.40.70.70.2-0.3-0.1-0.1-0.40.0-0.20.4-0.2-0.3
Saline control response0.40.61.50.60.10.10.1-0.7-0.20.8-1.0-0.5-1.10.90.9-1.0-1.2
Bone: connectivity density0.10.10.4-0.4-0.40.40.40.0-0.6-0.30.4-0.50.1-0.20.3-0.1-0.5
Bone: cortical apparent density1.31.73.5-1.7-1.21.01.01.4-0.8-1.81.9-0.41.7-1.6-0.41.30.7
Bone: cortical area0.20.40.70.80.7-0.6-0.6-0.70.50.8-0.80.7-0.60.5-0.2-0.30.2
Bone: cortical porosity0.10.10.10.30.3-0.1-0.1-0.20.10.4-0.30.2-0.30.30.1-0.30.1
Bone: cortical porosity0.30.30.60.80.6-0.4-0.4-0.60.40.8-0.70.4-0.70.70.0-0.50.0
Bone: cortical thickness0.71.12.2-1.1-0.80.60.61.0-0.6-1.41.30.21.4-1.5-0.71.41.1
Bone: cortical thickness0.50.61.5-0.5-0.10.20.20.40.1-0.81.00.70.9-0.9-0.91.11.2
Bone: cortical tissue density1.11.53.2-1.6-1.10.80.81.3-0.6-1.71.8-0.31.7-1.5-0.51.30.8
Condit. Reinf. active minus inactive responses1.82.03.7-1.8-1.71.81.81.9-1.4-1.51.4-0.91.5-1.40.50.60.5
Condit. Reinf. active-inactive response ratio1.21.32.3-1.3-1.31.41.41.5-1.0-1.21.1-0.31.2-1.20.30.60.9
Condit. Reinf. active responses1.82.24.2-1.8-1.82.02.01.8-1.7-1.31.1-1.71.1-1.01.20.0-0.2
Condit. Reinf. inactive responses0.50.62.0-0.8-0.80.90.90.6-0.9-0.40.3-1.40.3-0.10.9-0.3-0.9
Incentive salience index mean1.72.13.6-1.8-1.81.91.91.9-1.5-1.41.2-1.31.3-1.30.80.40.1
Condit. Reinf. lever presses0.60.71.7-1.0-1.11.21.21.0-0.8-0.70.4-1.30.5-0.60.8-0.0-0.6
Condit. Reinf. active minus inactive responses0.40.51.4-0.5-0.2-0.3-0.30.5-0.1-0.80.50.71.0-1.1-1.01.20.9
Condit. Reinf. active-inactive response ratio0.20.20.5-0.2-0.2-0.3-0.30.2-0.0-0.40.20.60.4-0.7-0.60.70.4
Condit. Reinf. active responses0.60.92.60.30.7-1.2-1.2-0.30.8-0.2-0.01.50.6-0.6-1.61.21.2
Condit. Reinf. inactive responses0.80.92.70.61.1-1.2-1.2-0.61.20.1-0.21.50.3-0.1-1.60.91.2
Condit. Reinf. lever presses0.10.20.50.20.5-0.6-0.6-0.30.70.1-0.20.30.2-0.0-0.60.40.3
Condit. Reinf. lever reinforcers received0.50.62.0-0.10.3-0.8-0.80.00.4-0.50.21.10.8-0.8-1.41.21.1
Conditioned reinforcement - actives0.60.61.2-1.0-1.00.40.40.9-0.8-1.10.7-0.21.0-1.1-0.30.60.4
Conditioned reinforcement - inactives0.10.10.3-0.2-0.1-0.1-0.1-0.00.3-0.3-0.00.30.4-0.5-0.50.60.3
Conditioned locomotion1.82.23.81.71.5-1.7-1.7-1.91.31.6-1.90.7-1.71.6-0.3-0.9-1.1
Patch foraging indifference point 0 sec0.00.10.1-0.2-0.40.30.30.1-0.3-0.20.1-0.20.1-0.10.00.1-0.3
Patch foraging indifference point AUC0.40.51.1-0.8-0.40.20.20.7-0.3-1.01.10.11.0-1.0-0.60.90.7
Delay disc. indifference point, 0s delay0.10.10.40.50.5-0.1-0.1-0.40.30.5-0.10.1-0.50.60.2-0.5-0.0
Delay disc. indifference point, 16s delay2.12.13.8-1.9-1.91.51.51.8-1.4-1.61.9-1.41.4-1.30.60.50.1
Delay disc. indifference point, 2s delay0.70.81.4-1.2-0.91.01.01.1-0.7-1.20.9-0.21.1-1.0-0.10.80.6
Delay disc. indifference point, 24s delay0.80.81.8-1.1-1.10.80.81.3-0.6-1.00.9-0.31.2-1.0-0.20.70.7
Delay disc. indifference point, 4s delay1.01.12.6-1.1-0.50.30.30.8-0.2-1.51.60.51.4-1.3-1.01.51.2
Delay disc. indifference point, 8s delay2.52.64.4-2.1-2.01.81.82.1-1.6-1.71.8-1.41.7-1.40.90.50.4
Indifference point function ln k1.52.14.01.81.5-1.2-1.2-1.70.91.9-2.00.3-1.81.80.3-1.4-1.0
Indifference point function log k1.52.14.01.81.5-1.2-1.2-1.70.91.9-2.00.3-1.81.80.3-1.4-1.0
Patch foraging total patch changes 0 sec0.10.10.3-0.3-0.50.50.50.3-0.5-0.20.1-0.40.1-0.20.3-0.1-0.4
Patch foraging total patch changes 12 sec0.50.61.4-0.5-0.2-0.1-0.10.60.3-0.80.90.80.9-0.9-1.11.21.2
Patch foraging total patch changes 18 sec0.40.51.2-0.9-0.80.60.60.5-0.6-1.11.1-0.10.7-0.9-0.30.8-0.1
Patch foraging total patch changes 24 sec0.30.41.30.60.4-0.1-0.1-0.70.10.7-0.6-0.4-0.90.80.4-0.8-1.1
Patch foraging total patch changes 6 sec0.60.81.4-0.9-0.80.60.60.9-0.6-1.11.10.41.1-1.2-0.91.10.8
Patch foraging time to switch 0 sec0.20.30.70.30.3-0.2-0.2-0.50.30.5-0.3-0.6-0.60.90.5-0.8-0.8
Patch foraging water rate 0 sec0.10.20.80.60.5-0.4-0.4-0.30.20.5-0.90.9-0.30.1-0.30.10.4
Patch foraging water rate 12 sec1.82.85.71.91.3-0.6-0.6-1.80.62.2-2.4-0.1-2.42.21.0-2.0-1.8
Patch foraging water rate 18 sec0.00.00.20.0-0.00.30.3-0.1-0.40.0-0.30.1-0.1-0.10.1-0.1-0.1
Patch foraging water rate 24 sec1.11.62.71.61.6-1.4-1.4-1.61.21.4-1.41.1-1.41.2-0.6-0.6-0.4
Patch foraging water rate 6 sec0.10.20.6-0.1-0.30.50.5-0.0-0.50.1-0.5-0.6-0.30.20.8-0.5-0.6
Seeking ratio, delayed vs. immediate footshock1.11.32.8-1.0-1.41.61.61.0-1.5-0.40.3-1.70.2-0.21.6-0.8-1.0
Distance traveled before self-admin0.30.30.9-0.5-0.30.00.00.6-0.4-0.60.30.20.7-1.0-0.50.80.6
Distance traveled after self-admin0.60.71.30.81.0-1.1-1.1-1.00.90.5-0.90.9-0.50.1-1.00.4-0.3
Extensor digitorum longus weight0.31.22.41.31.1-0.8-0.8-1.10.81.5-1.3-0.1-1.41.60.5-1.2-0.8
Bone: elastic displacement1.51.73.01.71.4-1.2-1.2-1.51.21.7-1.70.8-1.71.4-0.2-0.9-0.8
Bone: elastic work4.25.48.93.02.9-2.7-2.7-2.82.62.6-2.52.0-2.42.3-1.0-1.0-0.4
Bone: endosteal estimation3.16.911.63.43.0-2.7-2.7-3.22.53.3-3.21.5-2.92.9-0.3-1.9-0.8
Bone: endosteal perimeter3.36.813.03.32.5-2.0-2.0-2.91.73.6-3.60.4-3.43.31.0-2.8-1.7
Epididymis fat weight0.30.61.30.90.9-1.1-1.1-0.60.90.7-0.51.0-0.60.5-0.6-0.20.4
Delta time in closed arm before/after self-admin1.01.02.9-0.7-0.2-0.1-0.10.5-0.0-1.21.30.81.1-1.3-1.31.71.1
Delta time in open arm before/after self-admin2.92.85.91.91.3-0.6-0.6-1.81.12.2-2.4-0.3-2.32.11.1-2.1-1.7
Diff in mean of infusions in LGA sessions3.74.18.2-2.3-1.50.90.91.9-0.8-2.82.60.42.9-2.8-1.42.62.1
Delay discount exponential model param2.32.44.12.01.8-1.6-1.6-1.91.22.0-2.00.8-1.81.7-0.1-1.1-0.8
Extinction: sum of active levers before priming0.30.30.9-0.5-0.20.20.20.7-0.1-0.60.90.00.7-0.6-0.30.70.9
Active lever presses in extinction session 60.40.41.90.00.3-0.4-0.40.20.4-0.30.50.90.6-0.3-0.70.81.4
Bone: final force0.71.13.20.10.7-1.0-1.0-0.20.9-0.50.61.60.8-0.7-1.81.41.8
Bone: final moment1.01.64.10.31.0-1.3-1.3-0.41.2-0.40.52.00.8-0.7-2.01.52.0
Food consumed during 24 hour testing period1.51.85.90.91.4-1.6-1.6-0.91.30.2-0.32.40.1-0.1-2.31.21.4
Glucose1.62.43.8-1.9-1.81.71.71.8-1.9-1.91.8-0.91.6-1.70.30.90.5
Heart weight0.20.31.10.10.1-0.5-0.50.00.2-0.20.41.00.2-0.4-0.60.71.0
Delay discount hyperbolic model param1.71.83.21.81.5-1.3-1.3-1.71.11.7-1.80.6-1.61.5-0.0-1.0-0.7
Intermittent access intake day 1-15 change0.30.30.8-0.5-0.60.70.70.3-0.8-0.30.1-0.90.2-0.10.7-0.2-0.5
Intermittent access intake escalation0.40.41.0-0.3-0.50.70.70.2-0.80.1-0.2-1.0-0.20.21.0-0.7-0.7
Intermittent access intake escalation 20.20.20.6-0.6-0.70.50.50.5-0.8-0.60.4-0.40.5-0.50.30.20.1
Intermitt. access day 1 inactive lever presses1.11.22.81.01.4-1.3-1.3-1.11.70.5-0.41.6-0.30.2-1.60.70.7
Intermitt. access day 15 inactive lever presses1.61.75.60.10.9-1.1-1.1-0.11.1-0.60.52.01.0-1.0-2.41.91.9
Intermitt. access escalation Index0.00.00.10.10.2-0.2-0.2-0.1-0.10.20.10.1-0.20.40.0-0.2-0.2
Intermittent access day 1 total infusions0.40.41.00.50.5-1.0-1.0-0.40.70.3-0.61.0-0.00.1-1.00.20.5
Intermittent access day 15 total infusions0.20.20.70.40.3-0.5-0.5-0.50.10.5-0.80.3-0.40.5-0.2-0.5-0.2
Intermittent access terminal intake (last 3 days)0.20.20.50.40.3-0.7-0.7-0.50.30.3-0.70.5-0.10.3-0.5-0.10.1
Intermittent access total infusions0.30.30.70.60.4-0.8-0.8-0.50.30.6-0.80.6-0.40.6-0.4-0.50.0
Intermittent access day 1 locomotion0.20.20.50.50.2-0.3-0.3-0.40.20.6-0.7-0.1-0.60.70.3-0.7-0.6
Intermittent access day 15 total locomotion1.51.63.61.40.9-0.7-0.7-1.50.81.6-1.90.0-1.61.80.5-1.5-1.3
Intermittent access total locomotion1.11.32.31.31.1-1.0-1.0-1.41.21.4-1.50.4-1.21.50.1-1.0-0.6
Intermittent access standard deviation0.40.41.00.60.7-1.0-1.0-0.70.80.3-0.30.9-0.10.3-0.80.20.5
Left kidney weight9.225.845.76.06.6-6.8-6.8-5.56.44.6-4.45.7-3.53.9-4.2-0.01.7
Right kidney weight9.627.149.55.96.7-7.0-7.0-5.56.74.2-4.06.4-3.13.5-4.80.52.2
Cocaine induced anxiety1.92.24.41.72.1-1.9-1.9-1.62.01.2-0.91.9-0.71.0-1.50.11.2
Post-drug Anxiety1.01.12.21.01.4-1.3-1.3-0.91.50.5-0.31.5-0.10.3-1.30.51.2
Baseline Anxiety2.02.23.8-1.8-1.91.71.71.7-1.9-1.41.4-1.71.0-1.11.10.2-0.6
Tail length0.20.51.60.2-0.10.30.3-0.1-0.70.6-0.6-1.0-0.80.51.3-1.0-1.1
Length with tail0.10.20.70.50.3-0.4-0.4-0.3-0.30.6-0.8-0.1-0.60.40.3-0.3-0.5
Length without tail0.51.03.8-0.00.5-1.0-1.0-0.10.4-0.70.41.40.8-0.7-2.01.61.2
Times rat made contact with spout0.80.93.10.40.8-1.0-1.0-0.50.9-0.20.11.80.3-0.3-1.61.11.3
Lifetime Intake0.50.51.10.80.6-1.0-1.0-0.80.50.8-1.00.8-0.50.7-0.6-0.50.1
Liver weight, left0.20.41.0-0.10.5-0.6-0.6-0.20.4-0.50.60.80.6-0.3-0.90.81.0
Liver weight, right0.10.10.40.40.2-0.3-0.3-0.3-0.10.5-0.6-0.0-0.40.60.3-0.5-0.2
Locomotor activity1.01.72.81.71.6-1.4-1.4-1.61.51.4-1.41.4-1.31.1-0.6-0.40.0
Locomotor testing distance0.00.00.10.1-0.00.10.1-0.20.10.1-0.10.0-0.10.20.3-0.1-0.2
Locomotor testing rearing0.30.40.80.80.5-0.3-0.3-0.80.80.8-0.90.4-0.90.70.2-0.6-0.4
Locomotion in novel chamber2.43.07.81.00.10.10.1-1.1-0.81.8-1.8-1.7-2.22.22.3-2.7-2.8
Locomotion in novel chamber post-restriction0.50.61.8-0.5-0.81.11.10.4-0.9-0.0-0.2-1.3-0.00.31.2-0.7-0.7
Fecal boli incidents, locomotor time 10.00.00.20.10.2-0.1-0.1-0.20.50.1-0.30.10.10.1-0.30.2-0.0
Change in fecal boli incidents, locomotor task0.40.41.00.50.10.20.2-0.4-0.20.8-0.9-0.4-0.80.61.0-1.0-0.6
Time >=10cm from walls, locomotor time 10.20.20.50.50.7-0.6-0.6-0.70.50.4-0.10.2-0.30.6-0.1-0.2-0.0
Bouts of movement, locomotor time 10.20.30.6-0.6-0.50.00.00.6-0.0-0.70.80.10.7-0.6-0.30.60.6
Total resting periods, locomotor time 10.50.61.5-0.9-0.70.20.20.9-0.3-1.11.20.01.1-0.9-0.40.80.8
Rest time, locomotor task time 10.10.10.70.20.3-0.6-0.6-0.10.80.2-0.40.3-0.00.4-0.20.10.3
Distance moved, locomotor task time 10.00.00.20.20.3-0.1-0.1-0.4-0.10.0-0.00.2-0.1-0.1-0.20.1-0.1
Vertical activity count, locomotor time 10.10.10.2-0.3-0.10.10.1-0.0-0.4-0.40.40.20.3-0.4-0.30.40.1
Time >=10cm from walls, locomotor time 20.20.30.80.1-0.10.30.3-0.2-0.20.3-0.1-0.9-0.30.70.8-0.9-0.7
Bouts of movement, locomotor time 21.41.53.7-1.4-1.11.21.21.6-0.7-1.41.9-0.41.5-1.2-0.00.91.3
Total resting periods, locomotor time 21.81.94.3-1.6-1.21.31.31.8-0.7-1.62.1-0.21.8-1.5-0.21.11.5
Rest time, locomotor task time 20.20.20.5-0.6-0.60.60.60.7-0.2-0.40.5-0.30.4-0.40.10.20.0
Distance moved, locomotor task time 21.11.32.61.41.4-1.1-1.1-1.40.91.4-1.60.4-1.31.3-0.0-0.8-0.5
Vertical activity count, locomotor time 21.41.52.91.61.5-1.1-1.1-1.61.11.5-1.70.4-1.31.5-0.1-0.9-0.6
Light reinforcement 12.03.76.82.32.0-1.6-1.6-2.61.52.3-2.30.2-2.52.40.2-1.6-2.0
Light reinforcement 22.43.25.82.11.8-1.5-1.5-2.01.32.3-2.1-0.1-2.32.40.6-1.9-1.5
Bone: marrow area3.26.911.73.43.1-2.8-2.8-3.22.53.3-3.21.6-2.92.9-0.4-1.8-0.7
Bone: maximum diameter3.36.010.63.33.0-2.6-2.6-2.92.43.0-3.01.9-2.62.5-0.7-1.3-0.1
Bone: maximum force1.01.74.70.91.4-1.6-1.6-0.91.50.3-0.12.20.1-0.1-1.91.01.8
Bone: maximum moment1.32.36.41.11.6-1.9-1.9-1.01.80.3-0.22.50.1-0.1-2.11.22.0
Mean time between licks in bursts1.52.04.7-1.4-1.92.02.01.5-2.2-0.80.7-1.60.5-0.71.6-0.5-0.6
Mean num. licks in bursts2.02.46.70.91.7-2.0-2.0-1.11.7-0.10.02.30.4-0.2-2.61.61.7
Cd content in liver0.50.51.8-0.5-0.70.50.50.9-0.3-0.60.80.80.7-0.8-0.20.51.3
Co content in liver1.01.22.61.41.4-1.2-1.2-1.61.21.1-1.00.8-1.21.1-0.5-0.4-0.7
Cu content in liver3.23.910.4-1.7-2.32.52.51.5-2.7-0.80.6-3.20.3-0.32.6-1.2-2.0
Fe content in liver0.30.31.10.60.6-0.6-0.6-1.00.70.4-0.40.4-0.70.4-0.1-0.3-0.5
K content in liver0.30.31.20.00.5-0.7-0.7-0.30.7-0.30.10.50.4-0.3-1.10.90.2
Mg content in liver0.20.20.7-0.40.1-0.3-0.30.10.2-0.60.50.10.6-0.5-0.70.80.1
Mn content in liver0.70.81.31.01.1-1.0-1.0-1.11.10.9-0.90.4-0.90.9-0.4-0.3-0.6
Na content in liver3.03.25.5-2.2-2.32.12.12.4-2.2-1.81.5-1.11.8-1.90.70.80.5
Rb content in liver0.30.40.6-0.8-0.70.50.50.7-0.6-0.80.80.10.7-0.8-0.10.50.5
Se content in liver0.20.21.3-0.00.00.20.2-0.3-0.30.1-0.2-0.8-0.30.40.2-0.3-1.2
Sr content in liver0.40.30.6-0.6-0.70.80.80.6-0.7-0.30.3-0.80.2-0.20.7-0.2-0.3
Zn content in liver0.50.61.5-0.6-0.91.01.00.5-1.2-0.30.1-1.20.0-0.21.1-0.4-0.9
Bone: minimum diameter1.83.36.52.11.5-1.1-1.1-2.00.72.4-2.5-0.3-2.52.31.0-2.1-1.7
Time in familiar zone, hab. session 10.80.71.21.01.0-1.1-1.1-1.11.00.8-0.80.6-0.80.7-0.5-0.2-0.3
Time in novel zone, hab. session 10.10.10.4-0.2-0.50.60.60.3-0.5-0.00.1-0.0-0.0-0.10.5-0.30.2
Total zone transitions, hab. session 11.11.52.4-1.5-1.51.41.41.4-1.5-1.41.3-1.21.1-1.10.60.4-0.2
Total locomotion distance, hab. session 10.40.61.60.60.5-0.3-0.3-0.80.30.8-0.7-0.7-0.91.00.5-0.9-1.3
Locomotion velocity, hab. session 10.40.61.60.70.6-0.4-0.4-0.90.40.8-0.7-0.7-0.91.00.4-0.9-1.3
Time in familiar zone, hab. session 20.30.30.80.40.20.10.1-0.40.10.6-0.5-0.7-0.70.70.7-0.8-0.9
Time in novel zone, hab. session 20.20.20.7-0.2-0.2-0.1-0.10.1-0.2-0.50.40.80.5-0.6-0.60.60.8
Total zone transitions, hab. session 20.40.51.70.20.7-0.9-0.9-0.50.9-0.20.10.90.3-0.3-1.31.00.4
Total locomotion distance, hab. session 20.30.40.80.70.8-0.7-0.7-0.80.90.6-0.70.1-0.60.6-0.3-0.2-0.6
Locomotion velocity, hab. session 20.20.20.50.40.6-0.6-0.6-0.60.70.4-0.5-0.0-0.40.4-0.3-0.0-0.5
Novel to familiar place preference ratio0.30.30.60.80.6-0.6-0.6-0.70.20.6-0.70.8-0.50.5-0.2-0.30.4
Novelty place preference0.60.61.21.10.9-0.9-0.9-1.00.41.0-1.00.9-0.80.7-0.2-0.50.2
Time in novel zone, NPP test0.80.81.61.31.0-0.9-0.9-1.10.51.1-1.21.1-1.00.8-0.2-0.50.3
Total zone transitions, NPP test0.20.20.6-0.5-0.30.20.20.4-0.1-0.70.50.10.6-0.7-0.50.80.2
Total locomotion distance, NPP test0.60.81.21.00.9-0.8-0.8-1.10.91.0-1.0-0.1-1.11.10.1-0.7-1.1
Locomotion velocity, NPP test0.30.51.60.50.5-0.3-0.3-0.60.40.7-0.7-0.7-0.80.90.5-0.8-1.3
Intraocular pressure0.10.10.30.30.1-0.2-0.2-0.1-0.20.4-0.60.0-0.30.30.5-0.40.1
Delta distance traveled before/after self-admin2.42.65.01.91.8-1.6-1.6-2.21.91.7-1.91.1-1.81.5-0.7-0.7-0.9
Delta ambulatory time before/after self-admin1.61.83.31.61.5-1.4-1.4-1.81.61.4-1.51.2-1.41.2-0.7-0.4-0.5
Parametrial fat weight0.10.10.3-0.20.2-0.3-0.3-0.20.0-0.40.60.00.1-0.2-0.40.5-0.4
Pavlov. Cond. lever latency0.91.22.41.31.4-1.3-1.3-1.01.50.9-0.71.5-0.60.7-0.9-0.00.9
Pavlov. Cond. magazine entry latency3.03.86.2-2.5-2.42.22.22.3-2.2-2.32.1-1.32.0-2.10.41.10.4
Pavlov. Cond. change in total contacts2.83.04.8-2.2-2.12.02.01.9-2.0-2.01.8-1.41.7-1.80.50.90.1
Pavlov. Cond. index score2.02.54.1-2.0-2.01.71.71.9-1.8-1.91.7-1.11.6-1.70.40.90.2
Pavlov. Cond. latency score1.21.52.5-1.6-1.61.41.41.4-1.5-1.41.1-1.11.2-1.30.40.6-0.1
Pavlov. Cond. lever contacts1.21.42.9-1.4-1.61.51.51.1-1.6-1.00.7-1.70.7-0.81.0-0.0-1.0
Pavlov. Cond. magazine entry number3.24.06.42.52.5-2.3-2.3-2.52.32.3-2.21.4-2.12.1-0.6-1.0-0.5
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.3-0.20.40.40.0-0.3-0.30.2-0.30.1-0.10.10.1-0.4
Pavlov. Cond. lever-magazine prob. diff.2.43.04.8-2.2-2.22.02.02.0-2.0-1.91.7-1.41.7-1.80.60.80.0
Pavlov. Cond. response bias3.23.96.4-2.5-2.52.42.42.3-2.3-2.11.9-1.81.8-1.90.90.7-0.1
Pavlov. Cond. lever latency0.10.10.3-0.2-0.50.60.60.5-0.60.00.0-0.2-0.1-0.00.6-0.40.2
Pavlov. Cond. magazine entry latency0.70.81.8-1.3-0.80.50.50.9-0.5-1.31.3-0.71.2-1.1-0.20.90.1
Pavlov. Cond. change in total contacts0.60.82.5-0.20.5-0.9-0.9-0.20.7-0.80.60.90.9-0.9-1.61.50.7
Pavlov. Cond. index score0.20.30.7-0.7-0.2-0.0-0.00.3-0.1-0.80.8-0.30.8-0.7-0.50.80.0
Pavlov. Cond. latency score0.20.30.7-0.7-0.2-0.0-0.00.3-0.0-0.80.7-0.30.8-0.7-0.50.80.0
Pavlov. Cond. lever contacts0.20.20.70.10.5-0.6-0.6-0.40.7-0.20.20.40.3-0.2-0.80.70.1
Pavlov. Cond. magazine entry number0.30.30.80.70.20.10.1-0.2-0.10.9-0.80.3-0.90.80.5-0.90.0
Pavlov. Cond. intertrial magazine entries0.50.72.90.20.4-0.8-0.80.00.7-0.10.31.50.5-0.2-1.20.71.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.4-0.5-0.1-0.1-0.10.1-0.0-0.70.6-0.40.6-0.5-0.30.6-0.2
Pavlov. Cond. response bias0.30.41.1-0.50.1-0.3-0.30.10.4-0.80.70.30.8-0.7-0.91.00.3
Time in closed arm before self-admin1.11.22.5-1.3-1.41.61.61.2-1.3-0.80.6-1.30.6-0.61.3-0.4-0.5
Time in closed arm after self-admin0.10.10.2-0.5-0.50.30.30.2-0.5-0.40.4-0.30.1-0.40.30.1-0.4
Time in open arm before self-admin0.10.10.3-0.2-0.40.40.40.4-0.5-0.10.0-0.50.20.00.5-0.00.0
Time in open arm after self-admin1.61.83.71.61.2-0.6-0.6-1.31.01.9-1.8-0.4-1.71.81.0-1.7-0.9
Bone: periosteal estimation2.14.37.52.72.4-2.1-2.1-2.51.92.6-2.51.4-2.32.2-0.3-1.4-0.4
Bone: periosteal perimeter2.64.39.22.61.9-1.5-1.5-2.21.22.9-3.00.6-2.72.50.7-2.2-1.1
Bone: post-yield work1.52.05.8-1.0-0.50.00.01.10.2-1.61.61.41.8-1.9-1.62.02.4
Progressive ratio test 1 active lever presses0.10.10.4-0.5-0.60.20.20.5-0.2-0.40.3-0.10.6-0.4-0.00.10.4
Progressive ratio test 1 breakpoint0.30.30.8-0.8-0.90.40.40.7-0.5-0.70.5-0.20.8-0.60.00.20.4
Progressive ratio test 1 inactive lever presses0.10.10.3-0.00.1-0.3-0.30.10.5-0.10.10.40.2-0.3-0.40.40.5
Progressive ratio test 2 active lever presses0.80.92.5-0.10.4-1.1-1.1-0.00.8-0.60.41.40.9-0.6-1.61.21.4
Progressive ratio test 2 breakpoint0.91.02.8-0.20.4-1.0-1.00.10.8-0.70.41.51.0-0.8-1.71.31.5
Progressive ratio test 2 inactive lever presses0.70.82.6-0.20.4-0.9-0.90.10.6-0.60.21.30.9-0.9-1.61.31.3
Incentive Sensitization - Responses2.02.04.90.61.4-1.9-1.9-0.81.8-0.20.12.20.5-0.3-2.21.51.6
Incentive Sensitization - Breakpoint2.32.35.60.71.5-2.0-2.0-0.91.9-0.10.02.40.5-0.3-2.41.61.7
Sum of active levers in priming session hrs 5-60.20.20.30.50.6-0.6-0.6-0.40.50.4-0.20.3-0.30.4-0.3-0.00.2
Progressive ratio0.91.01.9-1.2-1.20.40.41.3-0.7-1.31.00.11.3-1.4-0.41.01.0
Food seeking constrained by brief footshock0.50.61.30.81.1-1.0-1.0-1.20.90.5-0.60.8-0.70.6-0.70.2-0.2
Seeking ratio, punishment vs. effort0.70.81.91.21.4-0.9-0.9-1.31.00.9-0.80.5-1.00.9-0.3-0.2-0.5
Retroperitoneal fat weight0.72.34.81.72.0-2.2-2.2-1.61.91.3-1.21.4-1.01.2-1.2-0.00.3
Reaction time number correct0.71.02.6-0.8-1.11.61.61.0-1.1-0.3-0.0-1.40.3-0.31.3-0.5-0.6
Reaction time mean minus median0.10.10.3-0.2-0.40.00.00.4-0.2-0.2-0.10.50.3-0.5-0.30.30.5
Reaction time mean minus median AUC0.20.20.70.40.2-0.4-0.4-0.00.40.5-0.70.8-0.10.1-0.3-0.00.7
Reaction time num false alarms0.30.41.3-0.3-0.71.11.10.3-0.9-0.0-0.1-0.4-0.2-0.00.8-0.5-0.6
Reaction time num false alarms AUC0.10.20.7-0.2-0.50.80.80.1-0.6-0.1-0.1-0.2-0.2-0.10.5-0.2-0.4
Reaction time trials correct on left0.71.02.6-0.8-1.11.61.61.0-1.1-0.3-0.0-1.40.3-0.31.3-0.5-0.6
Reaction time trials on left0.81.12.7-0.9-1.21.71.71.1-1.2-0.40.0-1.50.4-0.31.3-0.5-0.5
Reaction time mean0.60.81.5-1.1-1.20.40.41.2-0.9-1.11.2-0.11.1-1.0-0.20.60.8
Reaction time mean AUC0.60.81.6-1.1-1.20.40.41.3-1.0-1.11.1-0.01.1-1.1-0.20.60.8
Median of all reaction times0.91.32.8-1.5-1.40.50.51.5-1.1-1.41.7-0.11.4-1.3-0.30.90.9
Reaction time omissions1.11.53.1-1.4-1.51.41.41.8-1.1-1.31.2-0.51.3-1.50.40.70.9
Reaction time false alarm rate0.00.00.10.20.00.10.1-0.3-0.00.1-0.00.4-0.30.1-0.1-0.0-0.2
Reaction time premature initiation rate0.91.33.3-0.20.5-0.9-0.90.30.9-0.80.71.41.3-0.9-1.81.71.8
Reaction time premature initiations0.50.71.9-0.6-0.1-0.1-0.10.80.3-0.90.70.61.3-1.0-1.11.31.4
Std. dev. reaction times0.10.20.3-0.4-0.5-0.0-0.00.5-0.3-0.30.30.40.4-0.5-0.40.30.6
Reaction time trials completed0.81.12.7-0.9-1.21.71.71.1-1.2-0.40.0-1.50.4-0.31.3-0.5-0.5
Reaction time trials AUC0.50.81.9-0.7-0.91.41.40.8-0.9-0.2-0.1-1.30.2-0.21.2-0.6-0.5
Run reversals in cocaine runway, females1.81.85.9-0.2-0.70.80.8-0.2-1.40.4-0.1-2.2-0.91.12.3-1.8-2.4
Run reversals in cocaine runway, males0.50.51.81.00.8-0.2-0.2-0.80.51.0-1.30.5-0.90.80.0-0.6-0.3
Latency to leave start box in cocaine runway1.11.21.91.41.4-1.3-1.3-1.41.41.1-1.01.0-1.00.9-0.9-0.3-0.2
Latency to leave start box in cocaine runway, F0.30.30.70.50.7-0.7-0.7-0.70.80.2-0.20.6-0.30.1-0.70.3-0.1
Latency to leave start box in cocaine runway, M1.21.12.21.31.3-1.5-1.5-1.11.21.0-0.91.2-0.80.9-1.0-0.20.2
Std. dev. time between licks in bursts0.40.51.0-0.9-0.80.70.71.0-0.8-0.70.6-0.60.8-0.70.20.30.2
Total sessions with >9 infusions0.50.61.80.70.1-0.4-0.4-0.70.21.0-1.4-0.1-0.90.90.4-1.1-0.8
Short access day 1 total inactive lever presses2.02.34.41.61.7-2.1-2.1-1.71.91.0-1.22.1-0.90.7-1.70.50.4
Short access day 10 total inactive lever presses2.73.04.92.02.2-2.2-2.2-2.12.11.4-1.42.1-1.31.1-1.70.20.2
Short access day 1 total infusions0.80.91.71.01.0-1.2-1.2-1.30.90.6-1.01.3-0.60.6-1.00.2-0.1
Short access day 10 total infusions0.10.20.5-0.3-0.70.30.30.5-0.6-0.1-0.2-0.40.2-0.10.4-0.50.0
Short access total infusions0.40.51.00.80.6-0.9-0.9-0.70.60.7-1.00.9-0.40.6-0.6-0.30.2
Short access day 1 locomotion0.20.20.60.40.3-0.7-0.7-0.80.10.3-0.40.1-0.60.4-0.2-0.3-0.7
Short access day 10 total locomotion0.40.51.2-0.5-0.91.01.00.4-0.6-0.20.3-1.10.00.01.0-0.6-0.7
Short access total locomotion0.10.20.50.2-0.20.10.1-0.2-0.10.4-0.5-0.3-0.50.50.4-0.7-0.6
One hour access (0.3 mA shock)0.10.10.70.30.1-0.4-0.4-0.30.10.4-0.90.0-0.30.40.0-0.5-0.3
Compulsive drug intake0.50.61.9-0.5-0.2-0.3-0.30.5-0.0-0.80.40.60.9-1.1-1.11.40.8
One hour access (shock baseline)0.80.93.30.5-0.00.10.1-0.5-0.31.0-1.0-0.8-1.11.31.2-1.8-1.2
Social response proportion0.20.20.60.60.8-0.6-0.6-0.70.70.4-0.30.3-0.50.4-0.2-0.0-0.3
Social responses0.10.20.50.40.4-0.2-0.2-0.40.50.4-0.7-0.3-0.40.40.1-0.2-0.6
Social time2.63.45.5-2.3-2.12.12.12.1-1.8-2.32.3-1.22.0-2.10.41.30.3
Soleus weight0.30.92.7-0.20.3-0.6-0.60.30.6-0.70.71.20.9-0.8-1.51.41.6
Bone: stiffness0.71.24.0-0.8-0.50.20.20.8-0.3-1.11.21.11.3-1.3-1.11.42.0
Tibialis anterior weight0.00.00.2-0.10.0-0.1-0.10.0-0.0-0.10.2-0.4-0.00.20.0-0.0-0.4
Time to tail flick, vehicle, before self-admin0.10.10.30.10.3-0.2-0.2-0.20.5-0.1-0.10.40.2-0.1-0.40.30.4
Time to tail flick, vehicle, after self-admin0.20.30.80.1-0.20.40.40.0-0.30.4-0.4-0.8-0.30.50.9-0.9-0.5
Time to tail flick, test, before self-admin0.10.10.50.40.20.20.2-0.40.00.4-0.7-0.3-0.50.40.3-0.3-0.4
Time to tail flick, test, after self-admin1.01.01.6-1.2-1.31.31.31.0-0.9-1.01.0-1.30.7-0.81.00.2-0.5
Delta time to tail flick, vehicle, before/after SA0.20.20.50.00.2-0.6-0.6-0.00.1-0.20.30.60.3-0.2-0.70.60.7
Delta time to tail flick, test, before/after SA0.70.61.4-1.1-1.00.70.70.8-0.7-1.01.2-0.70.7-0.80.40.4-0.2
Tibia length0.20.41.40.70.7-0.7-0.7-0.50.80.4-0.41.2-0.30.2-0.80.30.7
Ambulatory time before self-admin0.30.31.2-0.3-0.00.00.00.40.0-0.60.20.50.6-0.9-0.91.10.6
Ambulatory time after self-admin0.30.30.80.50.6-0.7-0.7-0.60.50.2-0.60.7-0.3-0.2-0.90.5-0.2
Bone: tissue strength0.20.20.80.10.3-0.5-0.50.00.4-0.20.10.80.3-0.3-0.60.70.9
Total heroin consumption0.30.41.50.20.5-0.5-0.5-0.10.4-0.1-0.01.00.5-0.2-1.00.91.2
Bone: trabecular number0.40.61.7-0.4-0.81.11.10.2-1.3-0.10.2-1.1-0.20.01.1-0.7-0.9
Bone: trabecular spacing0.91.23.81.21.5-1.4-1.4-0.82.00.9-0.91.2-0.40.6-1.20.40.7
Bone: trabecular thickness0.10.10.7-0.2-0.10.10.1-0.3-0.3-0.20.2-0.6-0.10.10.3-0.2-0.8
Bone: trabecular tissue density0.50.71.7-1.0-0.60.40.40.7-0.5-1.21.30.01.2-1.0-0.61.00.6
Water consumed over 24 hours1.61.95.21.51.6-1.8-1.8-1.31.60.9-1.02.3-0.50.4-1.70.51.1
Number of responses in last shaping day0.70.81.8-1.2-0.90.60.60.7-0.7-1.31.2-0.41.1-1.2-0.21.00.1