Hub : Genes

Shisa8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Shisa8	0.12	0.06	4.4e-11	0.13	0.12	0.12	0.13	5.0e-12	3.1e-11	2.9e-11	4.7e-12
2	NAcc	gene expression	Shisa8	0.13	0.06	3.0e-13	0.11	0.12	0.12	0.12	5.7e-13	1.7e-13	1.4e-13	5.0e-14
3	pVTA	isoform ratio	NM_001207022.1	0.06	0.04	4.0e-03	0.01	0.01	0.02	0	8.8e-02	1.4e-01	4.9e-02	2.0e-01
4	Brain	mRNA stability	Shisa8	0.4	0.1	0.0e+00	0.32	0.36	0.35	0.36	8.1e-30	2.1e-34	4.3e-34	7.7e-35
5	Eye	gene expression	Shisa8	0.45	0.33	2.9e-03	0	0.12	0.05	0.07	2.7e-01	7.7e-03	6.6e-02	3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.3	0.5	1.1	-0.8	-1.1	-0.6	0.4	0.5
Area under the delay curve	0.2	0.2	0.5	-0.2	-0.1	-0.5	0.7	0.4
BMI with tail	1.1	3.4	6.5	2.5	1.0	1.9	0.2	-2.5
BMI without tail	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2	-0.2
Body weight	1.3	5.6	7.2	2.7	2.7	2.6	-1.1	-2.3
Weight adjusted by age	0.8	0.9	2.1	-0.1	1.4	0.2	-1.4	0.5
Bone surface	0.2	0.4	1.2	-0.6	0.2	-0.2	-1.1	0.6
Bone volume	0.1	0.1	0.5	-0.2	0.1	-0.0	-0.7	0.3
Breakpoint value in progressive ratio session	0.2	0.2	0.6	-0.1	-0.5	-0.5	0.7	-0.3
Number of licking bursts	0.3	0.3	0.6	-0.8	-0.3	-0.7	0.1	0.6
Context. condit. distance diff. score	6.0	7.2	9.9	3.1	2.8	3.1	-2.1	-2.1
Locomotion velocity, session 1	0.8	0.8	2.8	-0.2	1.1	0.4	-1.7	0.3
Locomotion distance, session 1	1.6	2.0	3.9	-2.0	-1.0	-1.4	-0.2	1.8
Locomotion velocity, session 2	0.5	0.6	1.3	0.5	1.0	0.3	-1.1	-0.3
Locomotion distance, session 2	2.5	3.5	4.8	-2.0	-2.2	-2.1	1.7	1.1
Locomotion velocity, session 3	0.8	0.9	2.7	0.4	1.1	0.7	-1.6	0.3
Locomotion distance, session 3	1.0	1.1	2.6	-1.3	-0.6	-0.7	-0.6	1.6
Stereotopy head waving bouts, day 3	0.9	1.0	1.7	0.9	1.3	1.0	-0.9	-0.8
Stereotopy head waving duration, day 3	3.9	4.7	7.6	2.1	2.8	2.1	-2.1	-1.6
Locomotion velocity, session 7	0.2	0.2	0.3	0.4	0.4	0.4	-0.6	0.2
Locomotion distance, session 7	0.4	0.5	1.7	-0.1	-0.8	-0.5	1.3	0.2
Stereotopy head waving bouts, day 7	4.4	5.0	10.1	1.5	2.5	2.3	-3.2	-0.8
Stereotopy head waving duration, day 7	3.2	3.9	8.0	1.3	2.3	2.0	-2.8	-0.6
Locomotion velocity, session 8	2.2	2.7	3.4	1.8	1.6	1.6	-1.2	-1.8
Locomotion distance, session 8	0.8	1.2	1.6	1.2	1.1	1.2	-1.1	-0.8
Degree of sensitization distance	2.1	2.1	4.1	1.9	0.7	1.0	1.2	-2.0
Degree of sensitization stereotypy	3.2	3.5	7.9	1.1	2.1	2.0	-2.8	-0.4
Conditioned locomotion	0.7	0.9	1.4	0.9	0.9	1.1	-1.2	-0.1
Cocaine response after cond. corrected	0.1	0.1	0.3	0.2	0.2	0.3	-0.5	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.5	0.2	0.3	0.1	-0.7	0.2
Cocaine response before conditioning	0.1	0.1	0.3	-0.1	0.2	-0.6	-0.0	0.3
Saline control response	0.8	1.0	3.3	0.2	1.3	0.1	-1.8	0.3
Bone: connectivity density	0.1	0.2	0.5	-0.6	-0.7	-0.3	0.3	0.3
Bone: cortical apparent density	0.5	0.7	0.9	-0.9	-0.9	-0.8	0.7	0.7
Bone: cortical area	1.5	2.2	2.8	1.7	1.5	1.7	-1.0	-1.5
Bone: cortical porosity	0.5	0.5	0.8	0.9	0.8	0.6	-0.7	-0.5
Bone: cortical porosity	1.1	1.2	1.6	1.3	1.2	1.1	-1.1	-0.9
Bone: cortical thickness	0.5	0.8	1.6	0.7	-0.4	0.3	1.3	-1.2
Bone: cortical thickness	0.6	0.7	1.5	0.7	-0.1	0.2	1.1	-1.2
Bone: cortical tissue density	0.5	0.6	0.8	-0.9	-0.9	-0.8	0.7	0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.2	-0.4	-0.6	0.8	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.6	0.8	0.5	-0.5	-0.5
Condit. Reinf. active responses	1.2	1.5	2.8	-1.1	-1.0	-1.7	1.3	0.8
Condit. Reinf. inactive responses	2.6	3.0	5.1	-1.8	-1.5	-2.3	1.5	1.5
Incentive salience index mean	0.6	0.7	1.6	-0.5	-0.7	-1.1	1.3	0.3
Condit. Reinf. lever presses	0.7	0.9	1.8	-0.8	-0.7	-1.3	1.0	0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	0.2	-0.6	-0.0	1.0	-0.8
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.5	0.2	-0.6	0.1	1.2	-1.0
Condit. Reinf. active responses	0.5	0.6	1.2	0.9	0.7	0.8	-0.1	-1.1
Condit. Reinf. inactive responses	1.2	1.5	3.3	1.3	1.8	1.0	-1.1	-0.7
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.7	-0.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	0.6	0.3	0.5	0.2	-0.9
Conditioned reinforcement - actives	0.6	0.6	1.4	0.7	1.2	0.8	-0.6	-0.3
Conditioned reinforcement - inactives	0.3	0.3	1.0	0.0	0.1	-0.4	1.0	-0.5
Conditioned locomotion	1.5	1.9	3.2	1.8	1.2	1.4	-0.3	-1.6
Patch foraging indifference point 0 sec	0.3	0.5	0.7	-0.7	-0.8	-0.8	0.8	0.0
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.1	0.2
Delay disc. indifference point, 0s delay	0.6	0.7	1.6	1.3	0.8	0.7	-0.0	-0.9
Delay disc. indifference point, 16s delay	1.4	1.4	2.0	-1.4	-1.1	-1.3	0.9	1.2
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	0.6	0.4	0.1	0.4	-0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.4	0.2	0.1	-0.6	0.7
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	0.2	0.1	-0.4	1.1	-0.6
Delay disc. indifference point, 8s delay	0.8	0.8	0.9	-0.8	-0.8	-0.9	0.9	0.9
Indifference point function ln k	0.8	1.2	1.6	1.2	1.1	1.3	-0.8	-1.0
Indifference point function log k	0.8	1.2	1.6	1.2	1.1	1.3	-0.8	-1.0
Patch foraging total patch changes 0 sec	0.4	0.7	0.9	-0.9	-0.9	-0.9	0.9	0.2
Patch foraging total patch changes 12 sec	0.0	0.1	0.2	0.0	-0.0	-0.1	0.3	-0.4
Patch foraging total patch changes 18 sec	0.3	0.3	0.8	-0.3	-0.7	-0.4	0.9	-0.4
Patch foraging total patch changes 24 sec	0.2	0.2	0.4	-0.6	-0.5	-0.5	0.3	0.4
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	-0.5	-0.2	-0.9	0.5	-0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.3	-0.1	0.2	-0.0	-0.2	0.5
Patch foraging water rate 0 sec	0.3	0.4	0.9	-0.4	-1.0	-0.7	0.6	-0.5
Patch foraging water rate 12 sec	0.2	0.4	0.7	-0.8	-0.9	-0.6	0.1	0.5
Patch foraging water rate 18 sec	0.9	1.2	2.2	-1.5	-1.2	-1.4	0.3	0.9
Patch foraging water rate 24 sec	0.2	0.2	0.7	-0.0	-0.6	0.0	0.3	-0.8
Patch foraging water rate 6 sec	0.6	0.9	1.6	-1.3	-0.3	-1.0	-0.8	1.2
Seeking ratio, delayed vs. immediate footshock	4.0	4.6	8.3	-2.1	-2.9	-2.1	2.0	1.5
Distance traveled before self-admin	0.9	1.0	3.8	0.3	-0.6	-0.5	1.9	-0.6
Distance traveled after self-admin	0.2	0.3	0.7	0.4	0.3	0.1	0.6	-0.8
Extensor digitorum longus weight	0.1	0.4	0.8	-0.8	-0.6	-0.9	-0.1	0.6
Bone: elastic displacement	0.6	0.7	2.0	-0.0	1.2	0.3	-1.4	0.1
Bone: elastic work	2.0	2.6	3.4	1.6	1.8	1.6	-1.2	-1.7
Bone: endosteal estimation	1.9	4.1	10.2	1.2	2.5	1.6	-3.2	-0.3
Bone: endosteal perimeter	3.1	6.4	12.1	1.9	3.1	2.6	-3.5	-0.6
Epididymis fat weight	3.1	7.2	10.7	3.0	3.0	3.3	-2.1	-1.7
Delta time in closed arm before/after self-admin	1.2	1.2	2.2	1.5	1.1	1.0	0.2	-1.2
Delta time in open arm before/after self-admin	0.3	0.3	0.6	-0.5	-0.1	-0.0	-0.7	0.8
Diff in mean of infusions in LGA sessions	0.4	0.4	0.9	-0.6	-0.4	-0.8	0.9	0.4
Delay discount exponential model param	0.2	0.2	0.3	0.3	0.1	0.6	-0.6	-0.5
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	0.2	-0.3	0.4	-0.2
Active lever presses in extinction session 6	0.2	0.2	0.3	0.5	0.5	0.0	0.2	-0.6
Bone: final force	1.1	1.8	3.9	1.6	0.7	1.3	0.2	-2.0
Bone: final moment	1.3	2.1	4.5	1.7	0.9	1.4	0.0	-2.1
Food consumed during 24 hour testing period	1.3	1.6	2.6	1.6	1.3	1.1	0.1	-1.6
Glucose	0.3	0.5	0.9	-0.6	-0.6	-0.9	0.7	0.5
Heart weight	2.2	3.1	6.3	2.1	1.6	1.4	0.2	-2.5
Delay discount hyperbolic model param	0.1	0.1	0.3	0.1	-0.1	0.4	-0.6	-0.3
Intermittent access intake day 1-15 change	0.4	0.4	0.7	-0.7	-0.6	-0.9	0.5	0.4
Intermittent access intake escalation	0.5	0.5	1.0	-0.8	-0.6	-1.0	0.6	0.4
Intermittent access intake escalation 2	0.2	0.1	0.4	-0.5	0.0	-0.6	-0.0	0.3
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.8	0.7	-0.2	0.1	0.9	-1.4
Intermitt. access day 15 inactive lever presses	1.5	1.7	3.6	1.1	-0.7	0.3	1.7	-1.9
Intermitt. access escalation Index	0.2	0.2	0.5	-0.1	-0.6	-0.1	0.7	-0.3
Intermittent access day 1 total infusions	0.9	1.1	1.5	1.2	1.0	1.2	0.0	-1.2
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.0	-0.2	-0.2	0.7	-0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.2	0.4	0.2	0.0	-0.2
Intermittent access total infusions	0.2	0.3	0.4	0.6	0.4	0.5	0.3	-0.7
Intermittent access day 1 locomotion	0.4	0.4	0.6	0.7	0.5	0.6	0.3	-0.8
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.2	0.4	0.4	0.0	-0.4
Intermittent access total locomotion	0.4	0.4	0.8	0.8	0.5	0.6	0.4	-0.9
Intermittent access standard deviation	0.6	0.6	1.4	0.9	0.2	0.6	0.7	-1.2
Left kidney weight	11.1	31.2	42.8	6.5	5.6	6.1	-3.0	-5.9
Right kidney weight	12.1	33.9	48.4	7.0	6.0	6.2	-2.8	-6.3
Cocaine induced anxiety	0.8	0.9	2.2	0.9	-0.1	0.7	1.1	-1.5
Post-drug Anxiety	0.3	0.3	0.9	0.4	-0.3	0.5	0.5	-0.9
Baseline Anxiety	0.9	1.0	2.1	-1.2	-0.6	-0.9	-0.5	1.4
Tail length	0.2	0.5	0.9	-1.0	0.2	-0.6	-0.6	0.9
Length with tail	0.5	1.8	4.3	0.8	2.1	1.3	-1.4	-0.6
Length without tail	1.1	2.4	3.6	1.6	1.9	1.7	-0.6	-1.5
Times rat made contact with spout	0.6	0.7	1.3	1.0	1.0	0.4	0.2	-1.2
Lifetime Intake	0.8	0.9	1.9	1.1	0.4	0.8	0.9	-1.4
Liver weight, left	1.6	2.5	5.0	1.1	2.2	1.6	-2.0	-0.1
Liver weight, right	3.1	5.1	8.9	2.0	3.0	2.3	-2.7	-0.6
Locomotor activity	1.7	2.8	3.9	1.7	1.6	2.0	-1.5	-1.4
Locomotor testing distance	0.0	0.0	0.0	-0.2	-0.0	-0.0	-0.0	0.2
Locomotor testing rearing	1.4	2.2	3.9	1.6	2.0	1.5	-1.0	-1.0
Locomotion in novel chamber	1.1	1.4	3.4	-0.7	0.8	-0.2	-1.9	1.5
Locomotion in novel chamber post-restriction	0.8	1.0	1.9	-1.1	-0.8	-1.0	0.3	1.4
Fecal boli incidents, locomotor time 1	0.4	0.4	0.8	-0.6	-0.9	-0.7	0.5	0.5
Change in fecal boli incidents, locomotor task	1.0	0.9	2.0	0.4	1.0	1.3	-1.4	-0.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.3	-0.1	0.3	-0.2	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	-0.2	0.4	0.3	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.9	0.3	-0.6	0.0	0.9	-0.1
Rest time, locomotor task time 1	0.7	0.8	2.4	0.8	-0.6	0.1	1.6	-0.7
Distance moved, locomotor task time 1	1.2	1.3	3.3	0.6	1.8	0.8	-1.4	-0.3
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.2	0.7	0.0	-0.5	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.2	-0.1	-0.2	-0.2	0.6
Bouts of movement, locomotor time 2	0.4	0.5	1.3	0.6	-0.3	0.2	1.1	-0.8
Total resting periods, locomotor time 2	0.5	0.5	1.6	0.5	-0.5	0.1	1.3	-0.8
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.2	-0.7	-0.4	0.7	0.1
Distance moved, locomotor task time 2	1.1	1.3	3.1	1.1	1.8	1.0	-1.1	-0.6
Vertical activity count, locomotor time 2	0.5	0.5	0.9	0.6	0.9	0.7	-0.8	-0.5
Light reinforcement 1	0.4	0.7	2.7	0.3	0.1	0.8	-1.6	0.2
Light reinforcement 2	0.5	0.7	1.3	1.1	0.3	1.1	-0.8	-0.4
Bone: marrow area	2.0	4.4	10.6	1.2	2.6	1.7	-3.3	-0.4
Bone: maximum diameter	4.3	8.0	11.0	3.0	3.3	3.0	-2.4	-2.4
Bone: maximum force	2.1	3.6	6.4	2.4	1.4	2.0	-0.4	-2.5
Bone: maximum moment	2.4	4.1	7.2	2.5	1.5	2.1	-0.5	-2.7
Mean time between licks in bursts	0.4	0.5	0.7	-0.8	-0.6	-0.8	0.6	0.8
Mean num. licks in bursts	1.5	1.8	2.7	1.6	1.5	1.3	-0.4	-1.4
Cd content in liver	1.3	1.4	3.7	1.1	1.9	0.8	-1.0	-0.8
Co content in liver	0.4	0.4	0.9	0.9	-0.2	0.5	0.3	-0.9
Cu content in liver	3.2	3.8	5.8	-2.4	-1.8	-2.2	1.1	2.0
Fe content in liver	0.4	0.4	1.1	0.1	1.0	0.2	-1.1	-0.0
K content in liver	0.7	0.7	1.1	-0.8	-0.9	-1.0	1.0	0.1
Mg content in liver	1.2	1.2	2.7	-0.9	-1.0	-1.3	1.6	0.2
Mn content in liver	0.3	0.3	0.6	0.5	0.8	0.5	-0.7	0.1
Na content in liver	2.7	2.9	4.3	-1.9	-2.1	-1.7	1.1	1.5
Rb content in liver	0.1	0.1	0.2	0.0	0.4	-0.1	0.4	-0.3
Se content in liver	0.5	0.6	1.4	-1.0	-0.4	-0.7	-0.3	1.2
Sr content in liver	0.8	0.8	1.0	-0.9	-1.0	-1.0	0.6	0.9
Zn content in liver	0.8	0.9	1.7	-1.3	-0.8	-0.9	-0.1	1.2
Bone: minimum diameter	1.0	1.8	3.3	1.1	1.5	1.4	-1.8	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	0.5	0.4	-0.4	0.1
Time in novel zone, hab. session 1	0.5	0.5	0.8	0.7	0.4	0.7	-0.9	-0.7
Total zone transitions, hab. session 1	2.4	3.4	5.9	-2.4	-1.5	-1.9	0.0	2.3
Total locomotion distance, hab. session 1	1.5	2.2	4.4	-1.7	-0.4	-1.0	-1.6	2.1
Locomotion velocity, hab. session 1	1.6	2.2	4.3	-1.9	-0.6	-1.4	-1.0	2.1
Time in familiar zone, hab. session 2	0.7	0.7	1.6	0.1	1.2	0.3	-1.2	0.8
Time in novel zone, hab. session 2	0.4	0.4	1.0	0.1	-0.6	-0.1	0.7	-1.0
Total zone transitions, hab. session 2	0.5	0.6	1.1	-1.0	-0.7	-1.0	0.5	0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.4	-1.0	-1.2	-1.0	0.3	0.7
Locomotion velocity, hab. session 2	1.0	1.4	1.9	-1.4	-1.4	-1.4	0.4	1.1
Novel to familiar place preference ratio	2.7	2.8	3.8	1.4	1.8	2.0	-1.8	-1.3
Novelty place preference	3.7	3.8	5.0	1.7	2.2	2.2	-2.0	-1.4
Time in novel zone, NPP test	4.5	4.7	6.2	2.0	2.4	2.5	-2.2	-1.7
Total zone transitions, NPP test	1.8	2.5	4.9	-2.2	-1.3	-1.7	-0.0	1.8
Total locomotion distance, NPP test	1.0	1.4	2.5	-1.6	-1.3	-1.2	0.1	1.2
Locomotion velocity, NPP test	1.7	2.4	3.9	-2.0	-1.5	-1.6	0.2	1.7
Intraocular pressure	0.3	0.4	1.1	0.6	0.5	1.1	-0.6	-0.3
Delta distance traveled before/after self-admin	1.4	1.6	3.6	0.5	1.7	1.0	-1.9	-0.5
Delta ambulatory time before/after self-admin	1.7	1.9	4.0	0.5	1.9	1.1	-2.0	-0.7
Parametrial fat weight	0.1	0.2	0.3	0.6	-0.3	0.3	0.5	-0.5
Pavlov. Cond. lever latency	1.0	1.2	2.6	1.0	0.7	1.6	-1.1	-0.9
Pavlov. Cond. magazine entry latency	1.3	1.7	3.3	-0.8	-1.3	-1.5	1.8	0.5
Pavlov. Cond. change in total contacts	1.6	1.7	3.5	-0.9	-1.2	-1.7	1.9	0.3
Pavlov. Cond. index score	0.9	1.1	3.2	-0.4	-0.8	-1.3	1.8	0.1
Pavlov. Cond. latency score	0.8	1.0	2.7	-0.4	-0.7	-1.2	1.6	0.1
Pavlov. Cond. lever contacts	1.5	1.8	3.2	-1.1	-1.2	-1.8	1.6	0.8
Pavlov. Cond. magazine entry number	0.9	1.1	2.7	0.6	0.8	1.4	-1.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.6	-1.2	-1.3	-1.1	0.8	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	3.2	-0.6	-1.0	-1.4	1.8	0.3
Pavlov. Cond. response bias	1.4	1.7	3.6	-0.7	-1.2	-1.6	1.9	0.5
Pavlov. Cond. lever latency	0.7	0.9	1.7	1.2	0.8	1.3	-0.7	-0.4
Pavlov. Cond. magazine entry latency	4.6	5.3	8.5	-2.4	-2.9	-2.3	2.5	0.8
Pavlov. Cond. change in total contacts	1.2	1.7	3.7	-0.8	-1.5	-1.1	1.9	-0.7
Pavlov. Cond. index score	2.6	3.4	5.1	-1.9	-2.3	-2.0	2.0	0.5
Pavlov. Cond. latency score	3.4	4.2	6.2	-2.1	-2.5	-2.2	2.3	0.6
Pavlov. Cond. lever contacts	0.7	1.0	1.7	-1.1	-1.1	-1.3	0.9	0.2
Pavlov. Cond. magazine entry number	2.7	3.3	6.0	1.8	2.5	1.7	-2.1	-0.4
Pavlov. Cond. intertrial magazine entries	2.2	2.8	5.6	2.4	1.5	1.5	0.2	-2.1
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.4	5.1	-2.0	-2.3	-2.0	1.9	0.7
Pavlov. Cond. response bias	1.1	1.5	2.3	-1.3	-1.5	-1.3	1.4	0.1
Time in closed arm before self-admin	4.5	5.1	8.2	-2.6	-2.1	-2.9	1.4	2.0
Time in closed arm after self-admin	0.5	0.5	1.7	0.9	1.3	0.2	-0.1	-0.5
Time in open arm before self-admin	0.2	0.3	0.6	-0.0	0.5	0.5	-0.8	0.5
Time in open arm after self-admin	0.5	0.6	1.4	-0.8	-0.2	0.1	-1.0	1.2
Bone: periosteal estimation	2.2	4.6	7.4	1.8	2.6	2.1	-2.7	-1.1
Bone: periosteal perimeter	4.3	7.1	9.2	2.6	3.0	3.0	-2.9	-1.5
Bone: post-yield work	0.3	0.4	1.0	0.7	0.2	0.3	0.4	-1.0
Progressive ratio test 1 active lever presses	0.5	0.5	1.1	0.7	0.0	0.4	1.0	-1.0
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	0.6	0.0	0.3	0.8	-0.7
Progressive ratio test 1 inactive lever presses	1.3	1.4	3.9	0.9	-0.5	-0.1	2.0	-1.5
Progressive ratio test 2 active lever presses	0.5	0.5	1.9	0.1	-0.4	-0.3	1.4	-0.6
Progressive ratio test 2 breakpoint	0.6	0.6	2.1	0.3	-0.3	-0.3	1.5	-0.9
Progressive ratio test 2 inactive lever presses	1.4	1.6	4.9	-0.3	-1.4	-0.9	2.2	-0.7
Incentive Sensitization - Responses	0.5	0.5	1.6	-0.3	-0.3	-0.9	1.3	-0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.8	-0.1	-0.3	-0.7	1.3	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	-0.1	-0.4	0.2	0.1
Progressive ratio	0.2	0.2	0.4	-0.3	-0.4	-0.6	0.6	-0.1
Food seeking constrained by brief footshock	1.4	1.7	3.0	1.6	1.1	1.7	-0.5	-1.3
Seeking ratio, punishment vs. effort	0.6	0.7	1.5	1.1	0.7	1.2	-0.3	-0.7
Retroperitoneal fat weight	3.0	9.8	14.5	3.8	3.3	3.6	-1.7	-2.7
Reaction time number correct	1.0	1.4	3.5	-1.4	-0.6	-0.7	-0.6	1.9
Reaction time mean minus median	0.3	0.4	0.9	0.6	0.9	0.4	-0.8	-0.2
Reaction time mean minus median AUC	0.7	0.9	1.9	1.0	1.4	0.9	-0.7	-0.6
Reaction time num false alarms	0.4	0.5	2.1	0.1	0.4	0.3	-1.4	0.7
Reaction time num false alarms AUC	0.4	0.5	2.0	-0.0	0.2	0.2	-1.4	0.7
Reaction time trials correct on left	1.0	1.4	3.5	-1.4	-0.6	-0.7	-0.6	1.9
Reaction time trials on left	1.0	1.5	3.7	-1.5	-0.6	-0.8	-0.7	1.9
Reaction time mean	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.2
Reaction time mean AUC	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.3	0.2
Median of all reaction times	0.3	0.4	0.6	-0.7	-0.8	-0.6	0.7	0.4
Reaction time omissions	0.2	0.3	0.5	-0.6	-0.4	-0.4	-0.2	0.7
Reaction time false alarm rate	0.2	0.3	0.5	0.7	0.3	0.5	-0.7	-0.3
Reaction time premature initiation rate	0.3	0.4	0.6	-0.4	-0.8	-0.8	0.7	-0.3
Reaction time premature initiations	0.4	0.6	0.9	-0.9	-0.9	-0.9	0.5	0.4
Std. dev. reaction times	0.4	0.6	0.9	0.8	0.9	0.8	-0.8	-0.5
Reaction time trials completed	1.0	1.5	3.7	-1.5	-0.6	-0.8	-0.7	1.9
Reaction time trials AUC	0.8	1.2	3.0	-1.3	-0.5	-0.6	-0.7	1.7
Run reversals in cocaine runway, females	0.9	0.9	2.4	-0.8	0.0	-0.4	-1.1	1.6
Run reversals in cocaine runway, males	1.0	1.0	2.1	0.6	1.1	1.2	-1.4	-0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.4	0.1	0.3	0.1	-0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.2	0.7
Latency to leave start box in cocaine runway, M	1.6	1.5	2.5	1.5	1.0	1.3	0.3	-1.6
Std. dev. time between licks in bursts	0.9	1.1	1.9	-1.3	-1.0	-1.4	0.9	0.5
Total sessions with >9 infusions	1.5	1.7	2.9	1.7	1.1	1.2	0.4	-1.7
Short access day 1 total inactive lever presses	1.1	1.2	3.0	1.3	0.5	1.1	-0.0	-1.7
Short access day 10 total inactive lever presses	0.6	0.6	0.9	0.8	0.6	1.0	-0.6	-0.9
Short access day 1 total infusions	1.7	1.8	3.7	1.8	0.8	1.2	0.5	-1.9
Short access day 10 total infusions	0.6	0.6	1.1	1.1	0.2	0.7	0.8	-1.0
Short access total infusions	2.2	2.5	4.9	2.0	0.6	1.4	1.2	-2.2
Short access day 1 locomotion	0.3	0.4	0.8	0.7	-0.3	0.2	0.9	-0.7
Short access day 10 total locomotion	0.1	0.1	0.6	0.4	-0.1	-0.1	0.7	-0.1
Short access total locomotion	1.1	1.2	2.4	1.5	0.4	0.9	0.9	-1.4
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.5	-0.5	-0.4	0.7	0.4
Compulsive drug intake	1.5	1.5	2.7	-1.6	-1.3	-1.3	0.5	1.1
One hour access (shock baseline)	0.1	0.1	0.2	0.4	0.4	0.3	0.3	-0.0
Social response proportion	0.3	0.3	0.6	0.3	-0.4	-0.1	0.7	-0.8
Social responses	0.1	0.1	0.4	-0.2	0.1	-0.1	-0.6	0.3
Social time	1.7	2.2	3.8	-1.5	-1.3	-1.9	1.3	1.2
Soleus weight	0.1	0.3	0.5	-0.4	-0.7	-0.6	0.7	-0.1
Bone: stiffness	1.2	1.9	3.4	1.8	0.8	1.4	-0.1	-1.8
Tibialis anterior weight	0.9	3.0	5.8	-1.4	-2.4	-1.6	2.0	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	1.2	-0.0	0.3	0.1	-1.1	0.0
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.9	-1.2	0.3	-0.5	-1.6	1.7
Time to tail flick, test, before self-admin	0.8	0.7	1.6	0.2	1.3	0.4	-1.3	0.5
Time to tail flick, test, after self-admin	0.9	1.0	1.8	-1.3	-0.5	-1.1	0.2	1.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.4	0.2
Delta time to tail flick, test, before/after SA	2.1	1.9	2.8	-1.7	-1.4	-1.6	0.7	1.2
Tibia length	0.9	2.4	3.9	1.5	2.0	1.7	-0.9	-1.5
Ambulatory time before self-admin	0.8	0.8	2.5	0.2	-1.0	-0.5	1.6	-0.5
Ambulatory time after self-admin	0.1	0.1	0.3	-0.5	0.1	-0.5	0.1	0.0
Bone: tissue strength	0.2	0.2	0.2	0.3	0.4	0.4	-0.4	-0.5
Total heroin consumption	0.1	0.2	0.3	0.3	-0.3	-0.3	0.5	-0.5
Bone: trabecular number	0.1	0.2	0.3	-0.1	-0.2	0.4	-0.5	0.5
Bone: trabecular spacing	0.9	1.2	1.9	1.3	1.3	0.9	0.2	-1.4
Bone: trabecular thickness	0.3	0.4	1.5	-0.5	-1.2	-0.3	0.2	0.4
Bone: trabecular tissue density	1.6	2.3	4.0	-1.5	-2.0	-1.8	1.3	0.6
Water consumed over 24 hours	0.8	1.0	1.4	1.0	1.2	0.8	-0.6	-1.2
Number of responses in last shaping day	1.8	1.9	4.3	-0.6	-1.5	-1.6	2.1	-0.0