Hub : Genes

Shank3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Shank3 0.03 0.02 8.6e-04 0.03 0.03 0.03 0.03 5.2e-04 2.9e-04 8.4e-04 7.2e-04
2 PL isoform ratio XM_039079820.2 0.04 0.02 6.3e-05 0.04 0.03 0.03 0.03 1.2e-05 6.3e-04 4.0e-04 7.9e-04
3 Brain gene expression Shank3 0.09 0.05 7.7e-05 0.06 0.06 0.06 0.06 1.4e-06 6.9e-06 3.5e-06 2.6e-06
4 Adipose mRNA stability Shank3 0.04 0.03 2.5e-04 0.04 0.03 0.02 0.03 8.9e-05 3.9e-04 4.2e-03 1.9e-04
5 PL isoform ratio NM_021676.3 0.1 0.05 3.7e-06 0.05 0.05 0.04 0.05 6.0e-06 4.8e-06 1.2e-05 3.3e-06
6 Brain mRNA stability Shank3 0.03 0.02 1.5e-03 0.01 0.02 0.01 0.01 2.2e-02 4.3e-03 5.8e-02 1.3e-02
7 PL gene expression Shank3 0.13 0.07 3.9e-03 0.02 0.01 0.01 0.01 2.8e-03 3.3e-02 4.1e-02 8.4e-03
8 Liver mRNA stability Shank3 0.03 0.02 1.1e-03 0.02 0.02 0.01 0.02 4.5e-03 5.7e-03 1.7e-02 6.1e-03
9 RMTg alternative polyA XM_063264181.1 0.4 0.14 1.9e-03 0.01 0.13 0.12 0.05 1.5e-01 3.2e-04 5.2e-04 1.8e-02
10 NAcc gene expression Shank3 0.03 0.02 1.4e-04 0.02 0.03 0.02 0.02 9.0e-04 8.6e-05 1.7e-04 1.2e-04
11 Adipose gene expression Shank3 0.07 0.06 5.9e-03 -0 0.01 -0 0 3.7e-01 7.0e-02 4.6e-01 3.1e-01
12 LHb gene expression Shank3 0.52 0.16 4.7e-05 0.13 0.1 0.14 0.12 5.0e-04 2.7e-03 2.9e-04 8.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.81.33.91.7-1.0-0.01.0-0.11.80.12.01.21.60.4-0.2
Area under the delay curve1.31.57.1-0.21.21.11.1-0.90.81.0-0.1-2.71.21.31.5
BMI with tail2.38.016.3-4.03.02.7-3.9-2.4-3.62.5-3.2-1.6-2.50.6-2.2
BMI without tail0.92.87.3-2.20.90.7-2.7-0.5-2.60.7-2.0-0.1-2.3-0.8-1.6
Body weight1.04.39.5-3.12.21.9-2.8-1.6-2.61.7-2.70.0-2.10.2-1.5
Weight adjusted by age1.92.86.0-2.41.61.8-1.7-1.9-1.41.7-2.40.6-1.01.0-1.6
Bone surface0.81.53.91.00.31.21.0-1.12.01.11.50.72.01.4-0.1
Bone volume0.91.64.61.4-0.20.61.3-0.72.10.61.80.92.01.0-0.0
Breakpoint value in progressive ratio session0.40.51.2-0.90.60.9-0.3-0.9-0.30.9-0.5-1.10.01.00.1
Number of licking bursts0.10.10.30.50.1-0.4-0.00.30.1-0.30.50.30.0-0.6-0.2
Context. condit. distance diff. score0.81.02.6-1.0-0.0-0.0-1.50.1-1.60.1-1.20.2-1.6-1.1-0.7
Locomotion velocity, session 10.20.31.7-0.30.50.5-0.5-0.4-0.40.5-0.1-1.3-0.1-0.3-0.0
Locomotion distance, session 11.21.54.11.2-0.0-0.11.80.31.5-0.21.2-1.81.50.22.0
Locomotion velocity, session 20.50.51.5-0.50.60.9-1.1-0.9-0.50.9-0.4-0.1-0.3-0.1-1.2
Locomotion distance, session 20.40.51.60.80.2-0.11.30.21.1-0.20.4-0.51.00.11.1
Locomotion velocity, session 31.21.42.90.3-1.5-1.5-0.71.7-1.1-1.4-0.41.0-1.4-1.4-0.4
Locomotion distance, session 30.30.30.80.9-0.6-0.70.20.60.2-0.50.7-0.20.2-0.80.1
Stereotopy head waving bouts, day 31.21.54.21.60.10.11.5-0.42.10.11.80.71.90.60.6
Stereotopy head waving duration, day 30.50.61.41.2-0.7-0.40.80.31.1-0.51.10.80.9-0.00.5
Locomotion velocity, session 70.70.81.90.4-0.5-1.1-0.80.7-0.6-0.90.31.3-0.8-1.4-1.0
Locomotion distance, session 70.20.30.6-0.3-0.0-0.7-0.30.5-0.7-0.4-0.4-0.4-0.7-0.80.3
Stereotopy head waving bouts, day 70.60.61.70.9-1.3-0.20.80.11.1-0.10.81.20.90.5-0.4
Stereotopy head waving duration, day 71.01.22.81.6-1.7-0.90.70.81.1-0.81.41.50.7-0.3-0.6
Locomotion velocity, session 80.70.94.3-0.1-0.70.1-1.5-0.2-0.80.10.11.3-0.8-0.7-2.1
Locomotion distance, session 80.40.61.3-1.10.80.9-0.9-0.8-0.90.9-1.1-0.2-0.6-0.0-0.3
Degree of sensitization distance1.21.23.0-1.71.31.1-1.1-1.3-1.11.2-1.3-0.1-0.70.9-0.5
Degree of sensitization stereotypy0.50.52.10.4-1.4-0.60.00.70.1-0.60.11.4-0.2-0.3-0.8
Conditioned locomotion0.30.31.0-0.20.4-0.2-1.0-0.2-0.6-0.1-0.30.6-0.6-0.8-0.9
Cocaine response after cond. corrected0.60.71.8-1.10.10.4-1.4-0.4-1.30.5-1.0-0.1-1.10.2-0.9
Cocaine response after cond. not corrected1.41.64.4-1.70.20.5-2.1-0.5-2.00.6-1.6-0.2-1.7-0.1-1.3
Cocaine response before conditioning0.50.61.6-0.90.50.6-1.3-0.4-1.10.5-0.9-0.6-0.9-0.2-0.7
Saline control response1.31.73.7-1.51.81.7-1.0-1.8-0.61.9-0.7-1.20.01.5-0.5
Bone: connectivity density0.71.13.91.6-1.2-0.10.60.11.4-0.12.01.01.20.1-0.4
Bone: cortical apparent density1.41.94.32.1-0.6-1.31.91.21.8-1.31.60.71.3-0.81.3
Bone: cortical area1.11.78.3-0.92.91.7-0.5-1.80.21.7-0.4-0.10.50.9-0.6
Bone: cortical porosity1.21.33.3-1.01.81.5-0.6-1.7-0.11.8-0.2-0.90.41.3-0.3
Bone: cortical porosity2.12.25.3-1.91.91.9-1.0-2.1-0.62.3-0.9-1.1-0.01.8-0.5
Bone: cortical thickness0.20.32.80.01.70.40.3-0.50.50.40.00.30.5-0.10.3
Bone: cortical thickness0.30.41.90.1-0.3-0.5-0.20.5-0.5-0.9-0.2-0.4-0.6-1.40.6
Bone: cortical tissue density1.21.73.71.9-0.7-1.31.71.11.6-1.21.50.61.2-0.71.3
Condit. Reinf. active minus inactive responses1.21.33.0-0.61.71.4-1.2-1.7-0.31.50.2-0.70.10.5-1.6
Condit. Reinf. active-inactive response ratio0.20.30.80.40.60.3-0.5-0.50.10.50.8-0.40.3-0.3-0.9
Condit. Reinf. active responses1.61.95.2-1.12.01.6-1.7-1.9-0.81.7-0.4-0.4-0.30.4-2.3
Condit. Reinf. inactive responses1.11.42.2-1.41.41.4-1.4-1.3-1.01.2-1.1-0.5-0.70.4-1.5
Incentive salience index mean2.02.46.1-1.12.52.0-1.5-2.4-0.52.1-0.2-0.30.00.8-2.1
Condit. Reinf. lever presses1.62.36.1-1.32.51.8-1.4-2.3-0.61.9-0.60.1-0.20.6-2.0
Condit. Reinf. active minus inactive responses0.91.23.2-0.20.81.20.8-1.51.11.20.6-0.91.51.80.7
Condit. Reinf. active-inactive response ratio0.30.40.80.30.40.30.5-0.50.70.40.9-0.80.90.60.6
Condit. Reinf. active responses1.21.74.2-1.01.41.80.0-2.10.41.7-0.2-1.61.01.90.2
Condit. Reinf. inactive responses0.91.12.7-1.31.21.4-0.6-1.3-0.61.2-1.2-1.6-0.10.8-0.2
Condit. Reinf. lever presses1.31.83.9-1.41.82.0-1.0-1.9-0.41.9-0.7-0.90.21.3-0.9
Condit. Reinf. lever reinforcers received1.31.84.5-0.81.51.90.2-2.10.61.70.0-1.41.22.00.3
Conditioned reinforcement - actives0.50.91.9-1.30.81.3-0.7-1.4-0.51.3-0.5-0.2-0.11.2-0.9
Conditioned reinforcement - inactives0.20.21.0-0.3-0.50.1-0.5-0.2-0.30.1-0.41.0-0.4-0.3-0.8
Conditioned locomotion1.41.84.2-2.00.81.2-1.8-0.8-1.81.2-1.6-0.7-1.30.3-1.3
Patch foraging indifference point 0 sec0.20.41.0-1.00.50.8-0.7-0.5-0.70.7-0.7-0.4-0.50.7-0.6
Patch foraging indifference point AUC1.42.14.3-0.21.32.10.8-2.11.42.00.5-0.41.92.00.4
Delay disc. indifference point, 0s delay2.83.18.7-1.53.02.5-0.6-2.5-0.02.5-0.4-1.10.72.3-0.7
Delay disc. indifference point, 16s delay0.50.51.2-0.20.80.90.4-0.90.50.70.0-1.10.80.90.5
Delay disc. indifference point, 2s delay4.95.516.40.02.32.31.9-2.11.92.30.8-4.02.83.02.2
Delay disc. indifference point, 24s delay0.30.32.0-0.50.60.4-0.6-0.2-0.70.3-0.4-1.4-0.4-0.3-0.0
Delay disc. indifference point, 4s delay1.01.02.3-0.31.50.91.1-1.00.80.9-0.1-1.31.01.30.9
Delay disc. indifference point, 8s delay1.01.27.00.30.2-0.11.30.40.5-0.10.1-2.60.70.52.1
Indifference point function ln k1.01.85.0-1.80.2-0.2-1.70.2-2.2-0.2-2.0-0.0-2.1-0.4-1.2
Indifference point function log k1.01.85.0-1.80.2-0.2-1.70.2-2.2-0.2-2.0-0.0-2.1-0.4-1.2
Patch foraging total patch changes 0 sec0.10.20.5-0.70.20.6-0.5-0.2-0.50.4-0.4-0.4-0.30.6-0.4
Patch foraging total patch changes 12 sec1.21.53.9-0.61.62.00.0-1.70.51.70.2-0.91.11.9-0.2
Patch foraging total patch changes 18 sec1.11.74.30.9-0.21.21.4-1.11.90.81.5-1.02.11.31.1
Patch foraging total patch changes 24 sec0.40.82.00.7-0.30.90.6-0.91.20.61.4-0.21.40.9-0.1
Patch foraging total patch changes 6 sec0.71.03.0-0.71.01.70.0-1.50.51.5-0.4-0.00.71.6-0.0
Patch foraging time to switch 0 sec0.30.51.41.2-0.5-0.80.50.30.8-0.81.10.90.5-0.60.2
Patch foraging water rate 0 sec0.40.93.0-1.5-0.00.1-1.00.3-1.40.1-1.70.2-1.4-0.1-0.6
Patch foraging water rate 12 sec0.92.05.5-2.30.50.3-1.6-0.2-2.10.6-2.3-0.5-1.80.5-0.9
Patch foraging water rate 18 sec2.03.17.7-2.3-0.8-0.4-2.10.5-2.8-0.1-2.70.7-2.8-0.3-1.7
Patch foraging water rate 24 sec1.21.74.6-1.6-1.0-0.5-1.30.9-2.0-0.4-2.1-0.3-2.0-0.3-0.9
Patch foraging water rate 6 sec0.50.82.5-1.40.0-0.0-0.90.2-1.40.1-1.6-0.0-1.4-0.2-0.5
Seeking ratio, delayed vs. immediate footshock0.50.61.61.0-0.9-0.60.70.50.9-0.51.30.90.6-0.10.1
Distance traveled before self-admin0.60.81.71.20.8-0.41.30.41.3-0.41.2-0.01.0-0.41.1
Distance traveled after self-admin0.20.20.50.5-0.1-0.70.00.7-0.1-0.70.5-0.4-0.2-0.60.5
Extensor digitorum longus weight0.20.81.6-0.80.50.2-1.3-0.1-1.00.1-1.21.1-1.1-1.0-1.1
Bone: elastic displacement0.20.31.6-0.1-0.6-0.10.30.30.00.2-0.0-1.30.20.80.7
Bone: elastic work0.30.40.8-0.90.30.8-0.5-0.7-0.40.8-0.90.0-0.30.4-0.5
Bone: endosteal estimation0.51.02.6-1.11.11.6-0.6-1.4-0.11.5-0.5-0.20.11.0-0.9
Bone: endosteal perimeter2.85.913.5-1.73.63.5-0.7-3.70.53.60.0-1.21.43.1-1.5
Epididymis fat weight1.44.713.3-2.23.62.7-2.4-2.8-1.32.6-0.9-0.5-0.41.7-2.0
Delta time in closed arm before/after self-admin0.50.53.4-0.60.40.40.3-0.3-0.30.4-0.2-1.80.10.60.9
Delta time in open arm before/after self-admin0.10.11.10.10.3-0.1-0.10.10.2-0.1-0.21.00.00.1-0.2
Diff in mean of infusions in LGA sessions1.62.04.6-1.71.42.0-1.1-2.1-0.62.0-0.5-0.60.01.8-0.9
Delay discount exponential model param1.11.37.20.1-0.9-0.8-1.00.6-0.6-0.70.12.7-1.0-1.0-1.5
Extinction: sum of active levers before priming0.80.93.9-0.60.80.80.6-1.00.20.8-0.1-2.00.71.7-0.0
Active lever presses in extinction session 61.41.43.3-1.80.20.8-1.6-0.8-1.70.8-1.6-0.5-1.30.4-1.2
Bone: final force0.30.52.40.41.60.40.4-0.60.90.40.50.50.7-0.4-0.3
Bone: final moment0.30.41.60.61.30.30.5-0.41.00.30.50.60.7-0.5-0.2
Food consumed during 24 hour testing period1.01.33.2-1.50.70.5-1.8-0.8-1.60.6-1.40.3-1.4-0.2-1.3
Glucose0.30.51.3-0.30.60.70.4-0.50.40.90.3-0.80.71.01.1
Heart weight0.30.51.1-0.0-0.4-0.5-0.80.7-0.7-0.6-0.40.7-0.9-1.1-0.8
Delay discount hyperbolic model param1.41.67.9-0.0-1.1-0.9-1.20.7-0.9-0.8-0.12.8-1.2-1.1-1.7
Intermittent access intake day 1-15 change0.40.82.2-1.50.30.9-1.0-0.8-1.00.9-1.40.3-0.71.0-0.6
Intermittent access intake escalation0.51.02.5-1.60.40.9-1.0-0.9-1.00.9-1.30.3-0.61.1-0.7
Intermittent access intake escalation 22.32.74.9-2.11.32.0-1.3-2.2-0.82.0-1.51.1-0.32.2-1.5
Intermitt. access day 1 inactive lever presses0.20.91.9-1.40.71.2-0.8-1.2-0.61.2-1.3-0.0-0.40.8-0.7
Intermitt. access day 15 inactive lever presses1.12.35.0-1.5-0.9-0.3-2.10.3-2.1-0.3-1.82.0-2.2-1.0-1.7
Intermitt. access escalation Index0.40.61.20.8-0.7-1.00.51.10.1-1.01.1-0.60.1-0.21.0
Intermittent access day 1 total infusions0.20.31.4-0.0-0.5-0.4-0.20.6-0.5-0.40.3-1.2-0.4-0.40.6
Intermittent access day 15 total infusions0.20.20.7-0.8-0.40.2-0.5-0.0-0.80.2-0.4-0.6-0.50.40.3
Intermittent access terminal intake (last 3 days)0.91.23.5-1.90.51.2-1.2-1.1-1.31.2-1.1-0.6-0.71.3-0.3
Intermittent access total infusions0.30.41.8-0.8-0.00.4-0.4-0.2-0.70.4-0.2-1.3-0.30.50.5
Intermittent access day 1 locomotion0.20.32.6-0.20.30.30.0-0.1-0.20.30.3-1.60.20.50.7
Intermittent access day 15 total locomotion0.61.12.4-1.50.81.2-1.0-1.0-1.11.2-1.1-1.4-0.60.7-0.2
Intermittent access total locomotion0.60.71.8-1.20.20.5-1.0-0.3-1.20.5-1.0-1.3-0.80.3-0.1
Intermittent access standard deviation0.30.72.2-0.6-0.7-0.5-0.80.5-0.9-0.5-0.81.5-1.1-0.5-0.8
Left kidney weight2.913.527.7-5.33.23.2-5.0-3.1-4.43.3-4.40.8-3.41.4-4.0
Right kidney weight4.219.140.5-6.43.43.4-6.1-3.1-5.73.4-5.80.6-4.61.1-4.3
Cocaine induced anxiety0.50.82.5-1.30.6-0.2-1.20.1-1.6-0.2-1.00.5-1.30.4-0.2
Post-drug Anxiety0.91.02.7-1.20.6-0.4-1.30.4-1.6-0.4-1.11.0-1.6-0.3-0.6
Baseline Anxiety0.40.41.01.0-0.8-0.60.60.50.8-0.60.60.70.4-0.8-0.0
Tail length0.31.34.91.5-0.7-0.71.10.61.4-0.71.52.20.9-0.20.2
Length with tail0.10.42.6-0.30.60.40.2-0.40.30.4-0.21.60.20.70.1
Length without tail0.62.04.4-2.02.11.8-0.7-1.8-0.61.7-1.30.0-0.12.00.2
Times rat made contact with spout2.42.75.9-0.9-2.1-1.9-1.01.8-2.1-1.8-1.80.4-2.4-1.50.3
Lifetime Intake0.40.42.5-0.8-0.10.3-0.5-0.0-0.90.3-0.3-1.6-0.50.30.6
Liver weight, left0.60.92.4-1.21.31.5-0.3-1.4-0.11.5-0.9-0.20.21.0-0.0
Liver weight, right0.30.41.3-0.60.70.70.6-0.50.10.6-0.2-1.00.40.91.1
Locomotor activity1.21.94.4-1.41.92.1-0.6-1.6-0.21.9-0.4-1.40.42.0-0.4
Locomotor testing distance0.30.51.90.6-0.0-0.01.00.50.7-0.20.8-1.40.70.50.6
Locomotor testing rearing1.63.37.8-0.91.92.30.8-2.01.02.30.4-2.71.72.80.8
Locomotion in novel chamber2.12.75.3-0.3-2.3-1.2-1.61.4-1.5-1.2-1.42.0-2.1-2.1-1.5
Locomotion in novel chamber post-restriction0.40.61.40.20.20.80.3-1.10.70.91.2-0.81.01.0-0.5
Fecal boli incidents, locomotor time 10.40.52.00.6-0.3-0.60.80.70.4-0.5-0.2-1.40.3-0.21.4
Change in fecal boli incidents, locomotor task0.40.41.0-1.00.50.3-0.5-0.4-0.60.3-0.90.9-0.60.6-0.6
Time >=10cm from walls, locomotor time 10.80.92.2-0.81.31.0-0.5-1.2-0.10.8-0.61.5-0.01.0-1.3
Bouts of movement, locomotor time 10.50.61.80.4-1.3-0.4-0.70.1-0.2-0.40.41.2-0.4-1.0-1.3
Total resting periods, locomotor time 10.60.72.80.7-1.7-0.7-0.20.30.1-0.60.61.2-0.2-1.1-1.0
Rest time, locomotor task time 11.11.45.60.8-2.4-1.70.11.5-0.4-1.60.1-0.4-0.7-1.50.3
Distance moved, locomotor task time 10.71.03.9-0.92.01.5-0.4-1.2-0.11.30.1-0.20.41.3-0.6
Vertical activity count, locomotor time 10.92.26.4-1.52.52.1-1.0-1.9-0.42.1-0.7-0.20.11.7-1.2
Time >=10cm from walls, locomotor time 21.11.63.1-1.81.51.5-1.4-1.4-1.01.4-1.20.4-0.71.0-1.0
Bouts of movement, locomotor time 20.20.30.70.6-0.8-0.40.60.70.5-0.40.60.30.4-0.30.7
Total resting periods, locomotor time 20.20.30.70.7-0.8-0.30.60.50.7-0.20.80.10.6-0.10.8
Rest time, locomotor task time 21.21.53.61.2-1.8-1.90.81.90.3-1.80.7-0.4-0.1-0.91.1
Distance moved, locomotor task time 21.72.14.5-1.71.82.1-1.4-1.9-0.82.1-0.8-0.7-0.31.0-1.2
Vertical activity count, locomotor time 21.82.44.7-1.91.82.1-1.4-2.1-0.92.2-1.5-0.6-0.31.2-1.3
Light reinforcement 10.61.62.9-1.51.21.7-1.0-1.6-0.71.6-0.7-1.4-0.01.7-0.8
Light reinforcement 22.94.58.8-3.02.42.7-1.7-2.5-1.52.7-1.9-1.1-0.62.5-1.6
Bone: marrow area0.40.82.3-0.91.11.5-0.5-1.3-0.01.4-0.4-0.20.31.0-0.9
Bone: maximum diameter1.32.59.1-1.43.02.2-1.4-1.9-0.61.9-0.6-0.7-0.01.0-1.4
Bone: maximum force0.10.31.30.01.20.40.1-0.50.50.4-0.10.60.3-0.4-0.4
Bone: maximum moment0.10.20.60.20.80.20.2-0.20.60.30.00.80.3-0.5-0.3
Mean time between licks in bursts1.33.27.92.8-1.5-1.91.71.81.8-1.91.91.11.0-2.10.7
Mean num. licks in bursts0.50.81.8-0.9-1.4-0.8-0.20.8-1.1-0.8-1.3-0.1-1.2-0.00.7
Cd content in liver0.30.41.40.4-0.60.20.9-0.10.70.10.4-1.20.80.50.5
Co content in liver0.70.91.8-0.91.31.0-0.7-1.2-0.31.3-0.1-0.50.11.2-1.2
Cu content in liver2.42.97.11.6-1.8-2.60.72.6-0.0-2.70.70.2-0.7-2.50.8
Fe content in liver0.60.73.4-0.40.80.50.5-0.50.20.60.1-1.80.61.21.1
K content in liver0.40.41.20.9-0.2-0.2-0.1-0.00.6-0.21.11.10.5-0.0-0.7
Mg content in liver0.50.61.50.70.50.50.5-0.51.10.51.2-0.11.20.90.1
Mn content in liver0.40.42.00.30.30.5-0.4-0.60.50.50.50.70.60.6-1.4
Na content in liver2.62.88.32.1-0.60.02.2-0.52.90.02.30.22.80.91.1
Rb content in liver0.50.61.7-0.50.90.9-0.1-0.80.10.90.0-1.10.51.30.4
Se content in liver0.30.31.1-0.4-0.9-0.3-0.80.2-0.8-0.2-0.40.1-0.7-0.1-1.1
Sr content in liver1.41.32.51.6-1.1-1.51.11.40.8-1.51.00.20.4-1.20.5
Zn content in liver1.01.12.70.9-1.1-1.50.51.6-0.0-1.50.5-0.5-0.4-1.31.0
Bone: minimum diameter0.71.25.2-0.62.31.5-0.4-1.70.31.50.1-0.30.60.7-1.0
Time in familiar zone, hab. session 10.80.71.6-0.4-1.0-0.8-0.71.2-1.2-0.7-0.80.0-1.3-0.8-0.5
Time in novel zone, hab. session 10.80.82.10.80.50.60.9-0.81.30.61.3-0.41.40.70.6
Total zone transitions, hab. session 10.91.24.61.1-0.5-0.32.10.41.7-0.50.5-0.11.40.31.8
Total locomotion distance, hab. session 10.40.61.2-0.80.80.90.5-0.60.20.8-1.0-0.70.31.10.8
Locomotion velocity, hab. session 10.50.81.6-0.81.11.00.7-0.70.40.9-0.9-0.90.51.31.0
Time in familiar zone, hab. session 20.91.02.3-0.6-0.2-0.7-1.50.6-1.5-0.4-0.70.3-1.5-0.9-1.4
Time in novel zone, hab. session 20.90.92.31.2-0.60.11.4-0.01.5-0.01.3-0.21.40.41.2
Total zone transitions, hab. session 20.30.41.4-0.6-0.1-0.1-0.20.4-0.8-0.3-1.1-1.2-0.7-0.40.5
Total locomotion distance, hab. session 21.01.33.8-1.80.90.8-1.1-0.5-1.50.9-2.0-1.3-1.10.40.2
Locomotion velocity, hab. session 21.11.44.2-1.91.01.0-1.0-0.7-1.41.0-2.0-1.2-1.10.60.3
Novel to familiar place preference ratio0.80.91.81.3-1.1-1.20.11.20.3-1.21.10.8-0.1-1.2-0.4
Novelty place preference0.80.81.51.2-1.1-1.2-0.21.20.0-1.11.00.8-0.3-1.2-0.6
Time in novel zone, NPP test1.11.22.11.3-1.4-1.4-0.11.40.0-1.41.00.9-0.4-1.5-0.5
Total zone transitions, NPP test0.30.41.40.5-0.9-0.41.20.60.6-0.60.1-0.10.4-0.11.1
Total locomotion distance, NPP test0.30.51.0-0.80.60.90.1-0.7-0.10.9-0.8-1.00.10.80.6
Locomotion velocity, NPP test0.30.50.9-0.90.80.90.0-0.7-0.20.9-0.9-0.80.00.80.4
Intraocular pressure1.21.810.4-0.21.41.40.3-1.20.41.40.7-3.21.10.90.9
Delta distance traveled before/after self-admin1.61.74.6-1.2-0.9-0.3-2.10.3-2.2-0.3-1.30.2-2.0-0.7-1.5
Delta ambulatory time before/after self-admin0.91.23.0-0.8-1.0-0.4-1.70.4-1.7-0.4-1.0-0.1-1.6-0.9-1.2
Parametrial fat weight0.20.51.5-1.01.20.8-0.5-0.8-0.40.8-0.9-0.1-0.30.1-0.3
Pavlov. Cond. lever latency1.21.54.51.1-2.1-1.61.31.80.6-1.50.70.30.2-0.41.4
Pavlov. Cond. magazine entry latency0.30.41.70.90.6-0.00.4-0.30.8-0.11.3-0.30.9-0.10.3
Pavlov. Cond. change in total contacts1.01.14.20.62.01.00.2-1.30.90.91.2-1.11.20.1-0.5
Pavlov. Cond. index score0.30.31.60.41.30.5-0.0-0.80.40.40.7-0.30.6-0.1-0.4
Pavlov. Cond. latency score0.40.52.30.11.50.7-0.3-1.00.30.60.50.00.40.0-0.8
Pavlov. Cond. lever contacts1.11.34.3-0.72.11.5-1.2-1.7-0.41.4-0.2-0.6-0.00.2-1.4
Pavlov. Cond. magazine entry number0.50.62.1-0.9-0.9-0.0-0.70.4-0.9-0.0-1.41.0-1.1-0.2-0.6
Pavlov. Cond. intertrial magazine entries1.11.32.6-1.51.01.6-1.1-1.4-0.91.5-1.0-1.0-0.40.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.30.41.70.51.30.50.2-0.80.60.30.8-0.40.7-0.1-0.2
Pavlov. Cond. response bias0.30.41.8-0.11.40.7-0.4-0.9-0.00.70.5-0.90.30.2-0.3
Pavlov. Cond. lever latency0.60.82.11.2-0.8-0.71.40.71.2-0.71.0-0.30.9-0.21.2
Pavlov. Cond. magazine entry latency0.40.41.5-0.61.20.5-0.8-0.5-0.40.3-0.51.0-0.4-0.2-0.9
Pavlov. Cond. change in total contacts0.40.72.0-0.51.41.20.0-1.20.41.1-0.0-0.00.71.00.0
Pavlov. Cond. index score0.50.71.8-1.11.30.8-1.0-0.8-0.70.7-0.90.5-0.50.4-0.7
Pavlov. Cond. latency score0.81.01.8-1.31.30.8-1.3-0.9-1.00.8-1.10.8-0.80.3-1.1
Pavlov. Cond. lever contacts0.70.92.2-1.30.60.8-1.5-0.7-1.20.8-1.10.1-0.90.2-1.2
Pavlov. Cond. magazine entry number0.50.71.70.9-1.3-0.70.90.80.6-0.60.8-0.90.60.11.0
Pavlov. Cond. intertrial magazine entries0.40.72.2-0.6-1.5-0.8-0.20.8-1.0-0.6-0.9-1.0-0.90.30.5
Pavlov. Cond. lever-magazine prob. diff.0.60.81.7-1.21.30.8-1.0-0.7-0.80.7-1.00.6-0.60.3-0.8
Pavlov. Cond. response bias0.30.41.1-0.61.00.6-0.7-0.6-0.40.6-0.30.2-0.30.2-0.8
Time in closed arm before self-admin1.82.35.41.11.51.50.9-1.52.11.52.1-0.52.31.50.2
Time in closed arm after self-admin2.32.54.6-0.32.12.00.5-2.01.02.00.8-2.01.62.10.5
Time in open arm before self-admin0.60.71.90.3-1.4-1.20.10.8-0.3-1.2-0.10.9-0.6-1.30.0
Time in open arm after self-admin0.20.20.7-0.2-0.6-0.4-0.10.3-0.3-0.4-0.50.8-0.4-0.2-0.1
Bone: periosteal estimation0.91.96.4-1.22.52.1-0.6-2.00.12.0-0.5-0.30.51.3-0.9
Bone: periosteal perimeter2.34.011.9-1.63.52.7-0.9-3.00.12.9-0.4-0.40.82.2-1.5
Bone: post-yield work0.81.12.31.1-0.6-1.41.21.50.6-1.40.6-0.00.2-1.11.5
Progressive ratio test 1 active lever presses0.50.71.90.5-1.1-1.1-0.21.1-0.4-1.10.10.3-0.7-1.4-0.0
Progressive ratio test 1 breakpoint0.50.61.80.6-1.1-1.1-0.11.1-0.3-1.10.30.3-0.6-1.30.0
Progressive ratio test 1 inactive lever presses0.10.10.2-0.50.40.4-0.3-0.4-0.20.40.00.5-0.10.4-0.2
Progressive ratio test 2 active lever presses0.50.61.2-1.1-0.20.6-1.1-0.5-1.10.6-1.1-0.2-0.80.1-0.8
Progressive ratio test 2 breakpoint0.40.40.9-0.9-0.20.5-0.9-0.5-0.90.5-0.9-0.3-0.70.1-0.6
Progressive ratio test 2 inactive lever presses0.50.82.0-1.40.41.0-1.1-0.9-1.01.0-1.1-0.1-0.70.5-0.4
Incentive Sensitization - Responses1.01.52.8-1.61.01.7-1.2-1.7-0.81.7-1.1-0.4-0.31.1-1.0
Incentive Sensitization - Breakpoint1.01.42.6-1.50.91.6-1.1-1.6-0.81.6-1.1-0.5-0.31.0-0.9
Sum of active levers in priming session hrs 5-60.30.31.2-0.20.60.5-0.3-0.6-0.10.50.1-1.10.20.6-0.6
Progressive ratio0.10.20.7-0.20.20.0-0.6-0.3-0.50.1-0.20.1-0.5-0.3-0.8
Food seeking constrained by brief footshock2.22.76.6-2.61.21.3-1.9-1.1-2.21.4-2.2-1.7-1.60.5-0.7
Seeking ratio, punishment vs. effort0.40.61.1-0.91.01.0-0.0-0.6-0.10.9-0.5-1.00.21.00.6
Retroperitoneal fat weight1.56.311.4-3.43.32.9-3.1-2.7-2.62.7-2.3-1.7-1.51.0-1.7
Reaction time number correct0.20.51.90.6-0.8-0.50.90.30.5-0.40.1-1.40.4-0.31.0
Reaction time mean minus median0.10.21.3-0.11.10.8-0.4-0.4-0.00.70.2-0.20.20.2-0.1
Reaction time mean minus median AUC0.10.10.4-0.40.30.6-0.6-0.2-0.40.4-0.30.2-0.30.1-0.2
Reaction time num false alarms0.20.21.00.8-0.20.00.2-0.20.70.11.00.10.6-0.00.0
Reaction time num false alarms AUC0.10.20.50.7-0.7-0.4-0.00.20.2-0.30.6-0.20.1-0.60.3
Reaction time trials correct on left0.20.51.90.6-0.8-0.50.90.30.5-0.40.1-1.40.4-0.31.0
Reaction time trials on left0.30.51.70.7-0.8-0.50.90.30.6-0.50.1-1.30.4-0.41.0
Reaction time mean0.71.22.61.2-1.1-1.50.31.60.2-1.30.71.3-0.3-1.6-0.0
Reaction time mean AUC0.71.12.31.3-1.2-1.40.41.50.3-1.20.91.3-0.1-1.50.0
Median of all reaction times1.62.34.71.5-1.9-2.20.42.20.1-1.90.81.8-0.6-2.1-0.1
Reaction time omissions0.81.12.71.6-1.3-1.00.51.00.8-0.81.30.90.4-1.6-0.2
Reaction time false alarm rate0.10.10.60.4-0.1-0.0-0.3-0.10.20.00.80.60.2-0.2-0.2
Reaction time premature initiation rate3.34.610.0-2.42.63.0-1.7-3.2-0.93.2-1.2-0.60.02.5-1.6
Reaction time premature initiations1.32.45.8-1.61.62.2-0.9-2.4-0.42.3-1.0-1.00.21.8-0.8
Std. dev. reaction times0.10.20.90.20.3-0.2-0.40.4-0.2-0.20.10.6-0.3-0.9-0.1
Reaction time trials completed0.30.51.70.7-0.8-0.50.90.30.6-0.50.1-1.30.4-0.41.0
Reaction time trials AUC0.20.41.60.5-0.7-0.40.70.30.4-0.4-0.1-1.30.3-0.40.8
Run reversals in cocaine runway, females0.30.30.80.2-0.6-0.7-0.30.7-0.4-0.70.10.4-0.6-0.9-0.6
Run reversals in cocaine runway, males1.61.610.50.30.40.51.0-0.30.60.61.2-3.21.10.91.8
Latency to leave start box in cocaine runway1.21.43.3-1.2-0.3-0.1-1.60.2-1.8-0.1-1.80.1-1.8-1.3-0.9
Latency to leave start box in cocaine runway, F3.13.67.2-1.0-1.3-1.2-2.30.9-2.3-1.1-1.92.4-2.7-2.2-2.4
Latency to leave start box in cocaine runway, M1.71.68.2-0.71.61.40.2-0.8-0.01.2-0.5-2.90.50.81.6
Std. dev. time between licks in bursts1.21.73.5-1.91.51.7-0.8-1.6-0.81.7-1.6-0.6-0.41.10.0
Total sessions with >9 infusions0.50.62.5-0.4-0.5-0.4-0.60.7-1.1-0.4-0.6-1.6-0.9-0.90.3
Short access day 1 total inactive lever presses1.82.46.0-1.90.50.4-2.4-0.2-2.40.4-1.90.4-2.2-1.0-1.6
Short access day 10 total inactive lever presses2.45.811.2-3.32.22.4-2.9-2.4-2.22.4-2.91.6-1.71.5-2.7
Short access day 1 total infusions0.70.92.6-1.0-0.7-0.3-1.20.6-1.6-0.3-1.2-0.7-1.5-1.0-0.3
Short access day 10 total infusions0.60.82.5-1.2-0.20.2-1.10.1-1.60.2-0.8-1.6-1.1-0.00.1
Short access total infusions0.70.93.7-1.1-0.20.1-1.00.3-1.50.1-0.9-1.9-1.1-0.30.4
Short access day 1 locomotion0.70.92.1-1.0-0.8-0.3-1.20.4-1.5-0.3-1.2-0.0-1.4-0.7-0.8
Short access day 10 total locomotion0.40.71.7-1.10.30.4-1.2-0.1-1.30.4-1.1-1.0-1.0-0.3-0.7
Short access total locomotion0.50.52.5-0.90.10.3-0.90.1-1.10.3-0.7-1.6-0.8-0.3-0.1
One hour access (0.3 mA shock)1.31.63.9-1.90.91.5-0.9-1.4-1.01.5-1.1-0.5-0.32.0-0.3
Compulsive drug intake0.20.32.4-0.00.10.20.10.1-0.20.20.5-1.60.20.50.5
One hour access (shock baseline)0.50.82.2-1.50.31.1-0.7-1.1-0.71.1-1.0-0.0-0.31.3-0.3
Social response proportion0.40.51.20.41.10.30.6-0.50.80.40.7-0.91.00.50.8
Social responses0.40.51.20.21.00.70.3-0.60.60.70.5-1.10.90.80.2
Social time0.60.81.9-0.4-0.5-1.1-0.80.8-1.3-0.8-0.90.3-1.4-1.1-0.5
Soleus weight0.51.63.6-1.50.50.5-1.9-0.3-1.70.3-1.80.8-1.7-0.8-1.4
Bone: stiffness0.30.52.30.70.6-0.40.60.20.8-0.30.31.50.4-0.9-0.2
Tibialis anterior weight0.00.20.60.20.3-0.2-0.50.0-0.1-0.10.10.8-0.2-0.8-0.4
Time to tail flick, vehicle, before self-admin1.92.04.7-1.51.21.4-1.4-1.7-0.71.4-1.61.6-0.60.6-2.2
Time to tail flick, vehicle, after self-admin0.40.50.9-0.90.40.8-0.9-0.9-0.50.8-0.40.9-0.30.7-0.8
Time to tail flick, test, before self-admin0.40.51.9-0.21.00.6-0.7-0.7-0.10.60.11.4-0.00.3-1.0
Time to tail flick, test, after self-admin1.92.04.2-1.3-0.40.0-2.00.0-1.70.0-1.72.0-1.9-1.0-1.8
Delta time to tail flick, vehicle, before/after SA0.80.81.70.9-1.3-0.80.80.90.5-0.81.2-0.60.5-0.21.2
Delta time to tail flick, test, before/after SA0.50.51.5-0.5-0.9-0.4-0.50.6-0.9-0.4-1.20.1-1.1-0.9-0.3
Tibia length0.82.29.71.1-0.6-1.22.51.01.5-1.20.80.11.20.43.1
Ambulatory time before self-admin0.30.41.00.80.5-0.80.50.80.4-0.80.6-0.10.1-0.81.0
Ambulatory time after self-admin0.30.30.70.2-0.3-0.8-0.50.7-0.6-0.80.2-0.3-0.7-0.80.0
Bone: tissue strength0.90.92.80.5-1.7-1.30.91.20.3-1.0-0.51.1-0.3-0.80.5
Total heroin consumption0.50.53.3-0.7-0.10.8-0.2-0.7-0.30.8-0.3-1.80.10.70.2
Bone: trabecular number0.71.23.41.6-1.5-0.20.6-0.01.40.11.81.21.30.2-0.5
Bone: trabecular spacing1.51.95.6-2.11.70.6-1.4-0.5-2.00.5-2.4-1.0-1.7-0.1-0.2
Bone: trabecular thickness0.50.71.30.20.81.20.2-1.00.91.10.9-0.31.10.9-0.2
Bone: trabecular tissue density1.01.53.71.60.1-0.81.90.91.8-1.01.00.81.2-1.01.5
Water consumed over 24 hours0.30.41.8-1.1-0.2-0.0-0.4-0.2-0.80.2-1.40.3-0.80.40.4
Number of responses in last shaping day0.60.62.30.7-1.5-0.90.30.80.2-0.9-0.30.6-0.3-1.50.1