Sh3bp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XM_006251248.5	0.13	0.08	9.8e-11	0.07	0.1	0.09	0.09	2.1e-08	1.0e-10	3.6e-10	2.7e-10
2	Liver	isoform ratio	XM_006251248.5	0.13	0.08	6.1e-16	0.13	0.14	0.14	0.14	1.8e-14	1.9e-15	9.6e-15	4.7e-15
3	Adipose	isoform ratio	XM_006251248.5	0.05	0.04	1.0e-08	0.07	0.07	0.07	0.07	1.3e-08	1.4e-08	1.4e-08	1.8e-08
4	Adipose	alternative TSS	XM_006251248.5	0.07	0.04	1.8e-11	0.1	0.1	0.1	0.1	4.4e-11	3.5e-11	3.0e-11	6.4e-11
5	PL	isoform ratio	XM_006251248.5	0.03	0.02	1.4e-03	0.03	0.02	0.03	0.02	8.8e-04	9.8e-04	8.5e-04	2.4e-03
6	Adipose	gene expression	Sh3bp2	0.1	0.06	3.4e-14	0.11	0.11	0.11	0.11	1.6e-12	1.3e-12	2.6e-12	5.6e-12
7	Brain	isoform ratio	XM_006251248.5	0.04	0.03	2.8e-05	0.06	0.05	0.06	0.06	5.3e-06	8.1e-06	3.3e-06	3.2e-06
8	Adipose	alternative TSS	NM_001414976.1	0.02	0.02	1.7e-03	0.03	0.02	0.02	0.02	8.6e-04	2.1e-03	1.2e-03	4.0e-03
9	Brain	mRNA stability	Sh3bp2	0.05	0.03	7.9e-05	0.03	0.04	0.04	0.03	4.4e-04	1.4e-04	6.9e-05	4.4e-04
10	Liver	gene expression	Sh3bp2	0.11	0.07	2.5e-05	0.05	0.04	0.04	0.04	6.9e-06	1.3e-05	7.9e-05	1.2e-05
11	Liver	mRNA stability	Sh3bp2	0.05	0.05	9.3e-03	0.02	0.01	0.01	0.01	2.7e-03	2.3e-02	1.4e-02	6.7e-03
12	Adipose	alternative TSS	XM_006251247.5	0.12	0.08	8.2e-11	0.06	0.09	0.09	0.08	9.2e-08	2.9e-10	2.8e-10	1.5e-09
13	Adipose	isoform ratio	XM_006251247.5	0.13	0.1	1.7e-11	0.09	0.1	0.1	0.09	4.6e-10	5.6e-11	4.7e-11	2.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	1.0	1.7	3.9	1.2	1.3	1.2	1.5	1.3	-1.4	1.3	-2.0	-1.0	-0.9	-0.9	1.5	1.2
Area under the delay curve	0.3	0.4	1.2	0.2	-0.1	-0.6	-0.6	-0.2	0.8	-0.6	0.4	1.1	-0.8	-0.8	-0.6	-0.6
BMI with tail	2.0	6.9	12.0	-2.1	-2.6	-2.1	-2.7	-2.9	3.3	-2.1	3.0	2.4	1.4	1.4	-3.5	-3.5
BMI without tail	1.6	4.8	8.2	-1.9	-2.3	-1.8	-2.1	-2.5	2.6	-1.8	2.4	1.7	1.5	1.5	-2.8	-2.9
Body weight	5.4	23.8	31.2	-4.9	-5.2	-5.2	-5.6	-5.2	5.6	-4.9	5.3	4.9	3.3	3.3	-5.1	-4.3
Weight adjusted by age	2.1	3.2	4.9	-1.6	-1.9	-2.0	-2.0	-1.9	2.2	-1.9	1.7	2.0	0.9	0.9	-1.9	-1.6
Bone surface	0.1	0.2	0.8	-0.2	-0.2	-0.5	-0.2	-0.1	0.3	-0.3	-0.9	0.8	-0.1	-0.1	0.2	0.4
Bone volume	0.1	0.3	2.0	0.2	0.3	0.1	0.5	0.3	-0.3	0.5	-1.4	-0.0	-0.1	-0.1	0.6	0.5
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.2	0.2	0.3	0.1	0.3	-0.2	0.3	0.2	-0.4	-0.0	-0.0	0.0	0.1
Number of licking bursts	1.2	1.9	2.9	-1.7	-1.5	-1.6	-1.6	-1.4	1.2	-1.6	1.3	1.3	1.5	1.5	-0.8	-0.4
Context. condit. distance diff. score	0.2	0.2	0.5	0.6	0.6	0.5	0.3	0.5	-0.5	0.7	0.3	-0.4	-0.4	-0.4	0.3	0.1
Locomotion velocity, session 1	0.8	0.9	1.7	1.0	1.1	0.7	1.1	1.1	-1.3	0.7	-0.6	-1.2	-0.5	-0.5	1.1	0.9
Locomotion distance, session 1	0.4	0.6	1.0	0.8	0.8	0.5	0.9	0.8	-0.8	0.4	-1.0	-0.7	-0.7	-0.7	0.7	0.6
Locomotion velocity, session 2	4.1	4.8	8.7	2.1	2.4	1.9	2.4	2.5	-2.9	1.7	-1.6	-2.3	-1.3	-1.3	2.7	2.6
Locomotion distance, session 2	2.9	4.0	5.8	2.4	2.4	1.4	2.2	2.4	-2.1	1.3	-1.8	-1.5	-2.2	-2.2	1.9	1.7
Locomotion velocity, session 3	0.3	0.3	0.8	0.7	0.7	-0.2	0.3	0.7	-0.4	-0.1	-0.2	0.1	-0.9	-0.9	0.5	0.6
Locomotion distance, session 3	0.1	0.1	0.2	0.2	0.1	-0.5	-0.2	0.1	0.2	-0.4	0.3	0.4	-0.4	-0.4	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.8	0.9	2.8	0.7	0.7	1.7	1.2	0.4	-0.9	1.6	-0.2	-1.6	0.1	0.1	0.3	-0.3
Stereotopy head waving duration, day 3	0.7	0.8	2.9	0.8	0.7	1.7	1.1	0.4	-0.7	1.6	-0.1	-1.4	-0.1	-0.1	0.1	-0.4
Locomotion velocity, session 7	1.0	1.0	2.3	-1.1	-0.9	-1.4	-1.4	-0.7	0.7	-0.9	1.5	1.3	0.9	0.9	-0.3	0.3
Locomotion distance, session 7	0.3	0.3	0.7	0.6	0.6	-0.3	0.0	0.7	-0.4	0.1	0.3	0.4	-0.9	-0.9	0.5	0.8
Stereotopy head waving bouts, day 7	1.2	1.3	4.1	-0.7	-1.1	-0.3	-1.1	-1.3	1.4	-0.4	1.5	0.8	0.5	0.5	-1.8	-2.0
Stereotopy head waving duration, day 7	2.0	2.4	4.5	-1.2	-1.5	-0.8	-1.7	-1.7	1.9	-0.9	1.9	1.4	0.9	0.9	-2.1	-2.1
Locomotion velocity, session 8	1.3	1.6	2.7	1.1	1.3	1.2	1.2	1.4	-1.6	1.2	-0.8	-1.2	-0.6	-0.6	1.6	1.6
Locomotion distance, session 8	1.6	2.3	3.5	1.8	1.9	1.4	1.7	1.8	-1.9	1.4	-0.9	-1.4	-1.3	-1.3	1.5	1.3
Degree of sensitization distance	0.9	0.9	2.6	0.6	0.8	0.9	0.8	1.0	-1.3	1.1	-0.6	-0.9	-0.2	-0.2	1.4	1.6
Degree of sensitization stereotypy	1.7	1.9	3.4	-1.1	-1.4	-0.9	-1.6	-1.6	1.7	-0.9	1.5	1.4	0.7	0.7	-1.8	-1.8
Conditioned locomotion	0.3	0.4	1.3	0.3	0.1	-0.5	-0.5	0.2	0.5	-0.4	0.1	0.9	-1.1	-1.1	-0.3	-0.1
Cocaine response after cond. corrected	1.3	1.6	2.8	1.6	1.5	1.7	1.4	1.3	-1.2	1.3	-0.8	-1.3	-1.3	-1.3	0.7	0.4
Cocaine response after cond. not corrected	0.5	0.6	1.1	1.0	0.9	1.0	0.9	0.8	-0.7	0.8	-0.4	-0.8	-0.8	-0.8	0.4	0.2
Cocaine response before conditioning	0.8	1.0	1.7	-1.3	-1.2	-1.3	-1.0	-1.0	0.8	-1.1	0.7	0.9	1.1	1.1	-0.5	-0.2
Saline control response	0.2	0.2	0.4	0.4	0.4	0.6	0.5	0.4	-0.6	0.3	-0.6	-0.4	-0.1	-0.1	0.6	0.5
Bone: connectivity density	0.7	1.1	2.1	1.1	1.1	0.8	1.1	1.1	-1.0	0.9	-1.4	-0.6	-1.0	-1.0	1.1	1.0
Bone: cortical apparent density	0.3	0.4	2.5	-0.1	-0.5	0.6	0.0	-0.7	0.8	0.1	-0.3	0.2	0.1	0.1	-1.1	-1.6
Bone: cortical area	5.4	8.3	12.9	-3.0	-3.0	-3.6	-3.1	-2.9	3.0	-3.4	2.6	3.3	2.3	2.3	-2.5	-1.9
Bone: cortical porosity	0.3	0.3	0.5	0.7	0.7	0.3	0.3	0.7	-0.7	0.3	0.5	-0.5	-0.5	-0.5	0.4	0.5
Bone: cortical porosity	0.1	0.1	1.0	0.3	0.2	-0.3	-0.1	0.2	-0.1	-0.3	1.0	0.1	-0.2	-0.2	-0.2	-0.2
Bone: cortical thickness	3.8	6.4	9.9	-2.3	-2.5	-3.0	-2.6	-2.5	2.7	-3.1	2.5	3.0	1.7	1.7	-2.5	-2.2
Bone: cortical thickness	0.3	0.3	1.1	0.4	0.2	0.0	-0.3	0.1	0.6	0.0	0.4	0.5	-1.0	-1.0	-0.7	-0.6
Bone: cortical tissue density	0.3	0.4	2.7	-0.1	-0.4	0.7	0.1	-0.7	0.8	0.2	-0.4	0.0	0.0	0.0	-1.1	-1.6
Condit. Reinf. active minus inactive responses	1.3	1.5	3.1	1.4	1.3	1.7	1.3	1.1	-1.0	1.8	-0.9	-1.3	-1.1	-1.1	0.7	0.3
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.8	1.9	1.9	1.8	1.9	1.7	-1.7	1.9	-1.4	-1.9	-1.3	-1.3	1.4	1.0
Condit. Reinf. active responses	0.6	0.7	2.3	0.9	0.8	1.4	0.8	0.7	-0.6	1.5	-0.6	-0.9	-0.7	-0.7	0.4	0.1
Condit. Reinf. inactive responses	0.9	1.1	1.9	-1.4	-1.3	-0.6	-1.3	-1.2	1.2	-0.6	0.8	1.2	1.0	1.0	-0.9	-0.6
Incentive salience index mean	0.2	0.3	1.1	0.4	0.3	1.0	0.5	0.3	-0.2	1.1	-0.5	-0.4	-0.4	-0.4	0.1	-0.1
Condit. Reinf. lever presses	0.4	0.5	1.1	-0.9	-0.9	-0.0	-0.8	-0.9	1.1	-0.0	0.2	0.9	0.5	0.5	-0.8	-0.6
Condit. Reinf. active minus inactive responses	0.4	0.6	1.2	-1.1	-0.9	-0.7	-0.8	-0.8	0.4	-0.5	0.7	0.6	1.1	1.1	-0.2	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	0.5	0.3	0.5	0.3	0.3	-0.1	0.6	-0.3	0.0	-0.7	-0.7	0.0	-0.1
Condit. Reinf. active responses	0.1	0.1	0.6	-0.2	-0.0	0.0	0.0	0.1	-0.4	0.4	-0.1	-0.0	0.4	0.4	0.6	0.8
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.1	0.2	0.3	0.3	0.3	-0.6	0.7	-0.3	-0.4	0.5	0.5	0.7	0.8
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.7	-0.7	-0.8	-0.7	-0.6	0.7	-0.7	0.8	0.8	0.5	0.5	-0.7	-0.5
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	-0.3	-0.1	-0.3	-0.2	-0.0	-0.0	0.1	0.2	0.3	0.2	0.2	0.2	0.5
Conditioned reinforcement - actives	0.3	0.5	1.0	-0.4	-0.6	-0.8	-0.8	-0.6	1.0	-0.8	0.4	1.0	-0.0	-0.0	-0.8	-0.7
Conditioned reinforcement - inactives	0.5	0.7	0.9	-0.9	-1.0	-1.0	-0.9	-1.0	0.9	-1.0	0.5	0.9	0.6	0.6	-0.8	-0.6
Conditioned locomotion	0.9	1.2	1.8	-1.0	-1.1	-1.2	-1.3	-1.1	1.3	-1.2	1.3	1.3	0.5	0.5	-1.2	-0.9
Patch foraging indifference point 0 sec	0.1	0.1	0.5	-0.1	-0.1	0.2	0.1	-0.1	-0.0	0.4	0.2	-0.3	0.7	0.7	-0.0	-0.1
Patch foraging indifference point AUC	0.2	0.3	0.7	0.3	0.4	0.5	0.8	0.4	-0.7	0.3	-0.8	-0.8	0.2	0.2	0.7	0.6
Delay disc. indifference point, 0s delay	1.2	1.4	3.4	0.7	0.2	-0.7	-0.9	0.0	1.2	-0.7	1.1	1.8	-1.8	-1.8	-1.2	-1.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.6	0.5	0.3	0.4	0.3	-0.2	0.3	-0.6	-0.1	-0.6	-0.6	0.1	-0.1
Delay disc. indifference point, 2s delay	0.4	0.5	2.0	0.9	0.6	-0.1	-0.2	0.5	0.3	-0.1	0.6	0.7	-1.4	-1.4	-0.3	-0.2
Delay disc. indifference point, 24s delay	0.4	0.4	1.0	0.5	0.1	-0.4	-0.3	-0.0	0.7	-0.4	0.0	1.0	-1.0	-1.0	-0.8	-0.9
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	0.8	0.7	0.3	0.3	0.6	-0.2	0.3	-0.5	0.1	-1.0	-1.0	0.5	0.5
Delay disc. indifference point, 8s delay	0.6	0.7	1.3	-0.8	-0.9	-1.0	-0.9	-0.9	1.0	-1.0	0.4	1.1	0.5	0.5	-0.8	-0.7
Indifference point function ln k	0.2	0.3	0.8	0.3	0.4	0.7	0.5	0.4	-0.7	0.9	-0.3	-0.6	-0.1	-0.1	0.6	0.6
Indifference point function log k	0.2	0.3	0.8	0.3	0.4	0.7	0.5	0.4	-0.7	0.9	-0.3	-0.6	-0.1	-0.1	0.6	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.8	-0.2	-0.2	0.1	0.1	-0.1	0.0	0.2	0.3	-0.3	0.9	0.9	-0.1	-0.2
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.6	-0.7	-0.5	-0.6	-0.6	0.7	-0.4	0.5	0.6	0.7	0.7	-0.6	-0.5
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.1	-0.1	0.4	0.2	-0.0	-0.0	0.3	-0.0	-0.4	0.5	0.5	0.1	-0.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.6	0.2	-0.0	-0.1	-0.0	-0.1	0.4	-0.0	0.5	0.3	-0.1	-0.1	-0.6	-0.8
Patch foraging total patch changes 6 sec	0.2	0.4	1.8	-0.7	-0.5	0.0	0.0	-0.4	0.0	-0.0	0.2	-0.4	1.3	1.3	-0.0	-0.1
Patch foraging time to switch 0 sec	0.8	1.7	3.1	-0.6	-1.0	-1.4	-1.5	-1.0	1.7	-1.5	1.5	1.8	-0.4	-0.4	-1.7	-1.6
Patch foraging water rate 0 sec	0.6	1.2	4.9	-1.5	-1.1	-0.7	-0.6	-0.9	0.1	-0.4	0.2	0.0	2.2	2.2	0.2	0.5
Patch foraging water rate 12 sec	0.1	0.2	0.7	-0.2	-0.1	0.6	0.4	-0.1	-0.5	0.4	-0.1	-0.8	0.8	0.8	0.2	0.0
Patch foraging water rate 18 sec	0.3	0.5	1.8	-0.7	-0.6	0.2	-0.1	-0.7	0.1	0.1	0.6	-0.3	1.4	1.4	-0.3	-0.5
Patch foraging water rate 24 sec	1.1	1.6	6.3	-1.6	-1.3	-0.3	-0.5	-1.3	0.3	-0.2	0.6	-0.3	2.5	2.5	-0.3	-0.3
Patch foraging water rate 6 sec	1.3	2.0	5.7	-1.9	-1.6	-0.9	-1.0	-1.6	0.8	-0.7	1.1	0.4	2.4	2.4	-0.8	-0.6
Seeking ratio, delayed vs. immediate footshock	2.1	2.6	5.2	1.1	1.4	1.7	2.0	1.4	-2.0	1.7	-2.3	-2.1	-0.1	-0.1	1.9	1.6
Distance traveled before self-admin	1.0	1.4	2.1	1.4	1.4	1.2	1.0	1.5	-1.2	1.2	-0.3	-1.0	-1.3	-1.3	0.9	0.8
Distance traveled after self-admin	0.3	0.4	1.7	0.8	0.6	0.2	0.1	0.6	0.1	0.2	-0.2	0.3	-1.3	-1.3	-0.2	-0.2
Extensor digitorum longus weight	2.5	9.8	13.3	-3.5	-3.6	-2.6	-3.3	-3.6	3.2	-2.3	3.5	2.2	3.1	3.1	-3.2	-2.9
Bone: elastic displacement	0.8	0.9	1.3	-1.1	-1.1	-0.8	-1.1	-0.9	1.0	-1.2	0.8	1.0	0.9	0.9	-0.7	-0.3
Bone: elastic work	3.5	4.5	6.4	-2.5	-2.5	-1.7	-2.4	-2.3	2.1	-1.9	2.2	1.9	2.3	2.3	-1.8	-1.3
Bone: endosteal estimation	0.9	1.9	4.2	-1.8	-1.5	-2.0	-1.7	-1.3	1.0	-0.9	1.3	1.4	1.5	1.5	-0.5	0.1
Bone: endosteal perimeter	0.8	1.7	3.3	-1.8	-1.5	-1.8	-1.5	-1.3	1.1	-1.3	0.8	1.4	1.3	1.3	-0.5	0.0
Epididymis fat weight	1.6	5.3	8.3	-2.3	-2.5	-2.2	-2.8	-2.5	2.9	-2.1	2.5	2.5	1.2	1.2	-2.6	-2.1
Delta time in closed arm before/after self-admin	0.9	0.8	1.3	1.1	1.1	0.9	0.8	1.1	-0.8	0.9	-0.6	-0.7	-1.1	-1.1	0.7	0.6
Delta time in open arm before/after self-admin	1.5	1.5	1.9	-1.1	-1.2	-1.3	-1.4	-1.2	1.4	-1.3	1.4	1.4	0.7	0.7	-1.4	-1.2
Diff in mean of infusions in LGA sessions	1.4	1.7	3.8	1.7	1.5	1.1	1.2	1.4	-0.9	1.1	-1.3	-0.7	-1.9	-1.9	0.6	0.3
Delay discount exponential model param	0.3	0.3	1.0	-0.3	0.0	0.5	0.4	0.1	-0.7	0.5	-0.3	-1.0	0.8	0.8	0.5	0.5
Extinction: sum of active levers before priming	0.6	0.6	1.3	-0.7	-0.8	-0.9	-0.9	-0.9	1.1	-0.9	0.3	1.1	0.2	0.2	-0.8	-0.8
Active lever presses in extinction session 6	0.3	0.2	0.8	0.5	0.2	-0.1	-0.2	0.2	0.4	-0.1	0.4	0.5	-0.9	-0.9	-0.6	-0.6
Bone: final force	4.7	7.6	12.1	-2.8	-2.8	-3.5	-3.1	-2.6	2.7	-3.1	2.9	3.3	2.2	2.2	-2.2	-1.6
Bone: final moment	4.2	6.7	10.8	-2.7	-2.6	-3.3	-2.9	-2.5	2.4	-2.8	2.9	3.0	2.3	2.3	-2.1	-1.5
Food consumed during 24 hour testing period	0.2	0.3	1.1	-0.5	-0.2	0.1	0.1	-0.2	-0.4	0.3	0.1	-0.5	1.1	1.1	0.5	0.6
Glucose	0.2	0.3	1.1	-0.7	-0.3	-0.2	-0.4	-0.1	-0.4	0.1	0.3	0.1	0.9	0.9	0.7	1.1
Heart weight	1.2	1.8	3.0	-1.5	-1.4	-1.7	-1.5	-1.3	1.2	-1.7	1.3	1.4	1.1	1.1	-1.0	-0.6
Delay discount hyperbolic model param	0.3	0.3	1.0	-0.4	-0.1	0.4	0.4	0.0	-0.6	0.4	-0.2	-1.0	0.8	0.8	0.5	0.4
Intermittent access intake day 1-15 change	2.2	4.6	5.9	2.4	2.4	2.3	2.3	2.3	-2.3	2.3	-1.8	-2.1	-2.0	-2.0	1.9	1.5
Intermittent access intake escalation	1.5	3.0	4.0	2.0	2.0	1.9	1.9	1.9	-1.9	1.9	-1.4	-1.7	-1.6	-1.6	1.5	1.2
Intermittent access intake escalation 2	2.2	2.6	3.7	1.5	1.7	1.8	1.8	1.7	-1.9	1.8	-1.4	-1.8	-1.0	-1.0	1.6	1.3
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.6	0.5	0.6	0.8	1.0	0.7	-0.8	0.8	-1.3	-0.8	-0.3	-0.3	0.8	0.6
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.9	0.7	0.8	0.9	0.9	0.8	-1.0	0.9	-0.8	-0.9	-0.4	-0.4	0.8	0.7
Intermitt. access escalation Index	0.6	0.8	1.2	0.9	1.0	1.0	0.9	0.9	-1.1	1.0	-0.4	-0.9	-0.8	-0.8	0.8	0.7
Intermittent access day 1 total infusions	0.5	0.9	2.0	-0.5	-0.8	-1.1	-1.0	-0.8	1.4	-1.1	0.4	1.4	-0.1	-0.1	-1.1	-1.1
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.3	0.2	0.0	0.2	0.2	0.0	0.0	-0.4	0.1	-0.4	-0.4	-0.0	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.4	0.4	0.3	0.4	0.3	-0.3	0.3	-0.6	-0.2	-0.3	-0.3	0.3	0.1
Intermittent access total infusions	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.2	-0.3	0.4	-0.4	-0.3	0.4	0.1	0.1	-0.3	-0.3
Intermittent access day 1 locomotion	0.5	0.6	1.1	-0.6	-0.7	-0.9	-0.9	-0.7	1.0	-0.9	0.6	1.1	0.2	0.2	-0.9	-0.8
Intermittent access day 15 total locomotion	0.2	0.3	0.7	-0.0	-0.2	-0.6	-0.5	-0.3	0.8	-0.6	0.4	0.9	-0.4	-0.4	-0.7	-0.7
Intermittent access total locomotion	0.0	0.0	0.1	0.1	0.0	-0.1	-0.0	0.0	0.2	-0.1	-0.1	0.3	-0.3	-0.3	-0.2	-0.2
Intermittent access standard deviation	0.3	0.6	0.8	0.8	0.8	0.8	0.8	0.8	-0.9	0.8	-0.5	-0.8	-0.6	-0.6	0.7	0.6
Left kidney weight	4.5	20.8	25.2	-4.7	-4.9	-5.0	-4.9	-4.9	4.7	-4.9	4.9	4.1	3.8	3.8	-4.5	-3.9
Right kidney weight	3.4	15.7	20.1	-3.7	-4.0	-4.5	-4.3	-4.1	4.3	-4.5	4.4	3.9	2.7	2.7	-4.2	-3.7
Cocaine induced anxiety	0.4	0.5	1.0	0.6	0.7	0.8	0.8	0.7	-1.0	0.8	-0.3	-1.0	-0.3	-0.3	0.8	0.7
Post-drug Anxiety	0.3	0.3	1.0	0.8	0.7	0.4	0.3	0.6	-0.3	0.4	-0.1	-0.1	-1.0	-1.0	0.1	0.1
Baseline Anxiety	1.4	1.6	3.7	-0.5	-0.9	-1.4	-1.4	-0.9	1.8	-1.4	1.0	1.9	-0.4	-0.4	-1.6	-1.5
Tail length	1.0	3.8	5.8	-2.4	-2.2	-2.3	-2.0	-2.1	1.6	-2.2	1.7	1.4	2.3	2.3	-1.2	-0.7
Length with tail	3.5	15.1	21.3	-4.6	-4.5	-4.3	-4.4	-4.2	3.8	-4.0	3.9	3.4	3.8	3.8	-3.1	-2.1
Length without tail	2.8	9.0	12.7	-3.4	-3.4	-3.3	-3.6	-3.2	3.2	-3.1	3.1	2.9	2.4	2.4	-2.7	-1.9
Times rat made contact with spout	0.9	1.1	1.9	0.6	0.9	1.1	1.2	0.9	-1.4	1.2	-1.1	-1.4	0.0	0.0	1.3	1.2
Lifetime Intake	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.2	-0.4	0.4	-0.4	-0.4	0.4	0.2	0.2	-0.3	-0.3
Liver weight, left	0.4	0.7	1.2	-0.9	-0.9	-0.8	-1.1	-0.9	0.9	-0.9	0.9	1.0	0.6	0.6	-0.8	-0.5
Liver weight, right	2.7	4.6	6.6	-2.4	-2.5	-1.3	-2.2	-2.6	2.5	-1.7	2.1	1.7	2.0	2.0	-2.4	-2.2
Locomotor activity	0.5	0.7	2.8	-1.1	-0.7	-0.5	-0.2	-0.4	-0.3	-0.1	0.0	-0.1	1.7	1.7	0.7	1.1
Locomotor testing distance	0.6	1.0	1.8	-1.3	-1.2	-0.9	-1.1	-1.1	0.9	-0.5	1.1	0.7	1.4	1.4	-0.6	-0.4
Locomotor testing rearing	1.2	2.3	4.4	-2.0	-1.8	-1.3	-1.5	-1.7	1.2	-1.1	1.6	1.0	2.1	2.1	-0.9	-0.6
Locomotion in novel chamber	0.4	0.5	1.0	1.0	0.9	0.8	0.5	0.9	-0.7	0.8	0.4	-0.5	-0.9	-0.9	0.3	0.2
Locomotion in novel chamber post-restriction	0.2	0.3	1.5	0.7	0.6	0.1	0.1	0.6	-0.1	0.1	-0.1	0.2	-1.2	-1.2	-0.1	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.4	0.9	0.4	0.5	0.9	0.7	0.6	-0.8	0.8	-0.2	-0.9	-0.1	-0.1	0.6	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.4	0.5	0.6	0.6	0.6	-0.8	0.5	-0.4	-0.6	-0.2	-0.2	0.8	0.8
Time >=10cm from walls, locomotor time 1	1.6	1.7	3.1	-0.6	-0.9	-1.3	-1.5	-1.0	1.7	-1.3	1.7	1.8	-0.3	-0.3	-1.7	-1.5
Bouts of movement, locomotor time 1	0.2	0.3	1.1	-0.1	-0.2	-0.3	-0.3	-0.2	0.6	-0.3	0.3	0.5	-0.5	-0.5	-0.9	-1.0
Total resting periods, locomotor time 1	0.3	0.3	0.9	-0.1	-0.2	-0.4	-0.4	-0.2	0.6	-0.3	0.7	0.5	-0.5	-0.5	-0.9	-1.0
Rest time, locomotor task time 1	1.7	2.1	3.5	-1.9	-1.7	-1.4	-1.6	-1.5	1.3	-1.3	1.8	1.1	1.5	1.5	-1.3	-0.9
Distance moved, locomotor task time 1	0.1	0.1	0.5	0.5	0.4	0.1	0.5	0.4	-0.3	0.1	-0.7	-0.1	-0.1	-0.1	0.3	0.0
Vertical activity count, locomotor time 1	0.6	1.5	2.5	1.3	1.3	1.2	1.4	1.2	-1.2	1.1	-1.6	-1.0	-0.9	-0.9	1.3	1.1
Time >=10cm from walls, locomotor time 2	0.4	0.7	1.0	-0.7	-0.8	-1.0	-1.0	-0.9	1.0	-0.9	0.8	1.0	0.5	0.5	-0.8	-0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	0.3	0.1	0.3	0.3	0.1	0.2	-0.4	0.0	-0.5	-0.5	-0.2	-0.5
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.2	-0.0	-0.2	-0.0	0.0	0.4	-0.1	-0.2	0.3	-0.3	-0.3	-0.5	-0.6
Rest time, locomotor task time 2	1.0	1.2	2.3	-1.5	-1.4	-1.2	-1.2	-1.2	1.1	-1.2	0.8	0.9	1.0	1.0	-0.8	-0.5
Distance moved, locomotor task time 2	0.4	0.5	1.0	1.0	1.0	0.6	0.8	0.8	-0.7	0.6	-0.6	-0.5	-0.7	-0.7	0.6	0.4
Vertical activity count, locomotor time 2	1.4	1.9	3.0	1.7	1.7	1.3	1.4	1.5	-1.4	1.4	-1.0	-1.1	-1.3	-1.3	1.3	1.2
Light reinforcement 1	1.9	4.6	5.8	-2.2	-2.3	-2.1	-2.3	-2.4	2.3	-2.2	2.2	1.9	1.9	1.9	-2.2	-2.0
Light reinforcement 2	2.6	4.1	5.7	-2.2	-2.3	-2.0	-2.2	-2.4	2.0	-2.0	2.1	1.7	1.7	1.7	-2.0	-1.7
Bone: marrow area	0.7	1.6	3.9	-1.6	-1.4	-2.0	-1.6	-1.1	1.0	-0.9	1.3	1.4	1.3	1.3	-0.5	0.1
Bone: maximum diameter	3.7	6.9	8.9	-3.0	-3.0	-2.9	-2.6	-2.9	2.6	-2.7	2.2	2.4	2.7	2.7	-2.3	-2.0
Bone: maximum force	3.2	5.7	8.4	-2.7	-2.6	-2.9	-2.7	-2.4	2.4	-2.5	2.2	2.7	2.2	2.2	-1.9	-1.3
Bone: maximum moment	2.8	5.0	7.2	-2.5	-2.4	-2.7	-2.4	-2.3	2.0	-2.2	2.2	2.3	2.3	2.3	-1.7	-1.2
Mean time between licks in bursts	0.7	1.6	3.1	0.6	1.0	1.3	1.4	1.0	-1.7	1.4	-1.2	-1.8	0.3	0.3	1.7	1.6
Mean num. licks in bursts	2.5	4.0	5.4	2.1	2.2	2.2	2.3	2.0	-2.1	2.3	-2.1	-2.2	-1.5	-1.5	1.8	1.3
Cd content in liver	0.1	0.1	0.6	0.0	0.2	0.2	0.0	0.2	-0.4	0.0	-0.2	-0.2	0.0	0.0	0.6	0.7
Co content in liver	0.4	0.5	1.5	-0.4	-0.3	-1.2	-0.9	-0.2	0.4	-1.2	1.1	1.1	-0.0	-0.0	-0.2	0.2
Cu content in liver	1.0	1.2	1.8	1.3	1.3	1.0	1.0	1.4	-1.2	1.0	-0.7	-0.6	-1.3	-1.3	1.0	0.9
Fe content in liver	3.2	3.8	7.0	2.6	2.6	1.3	1.9	2.5	-2.1	1.4	-0.7	-1.3	-2.4	-2.4	1.6	1.3
K content in liver	0.3	0.3	1.1	0.5	0.3	-0.5	-0.0	0.4	0.2	-0.6	-0.4	0.7	-1.0	-1.0	-0.1	0.0
Mg content in liver	1.2	1.2	2.9	-0.9	-1.0	-1.5	-1.2	-0.9	1.2	-1.7	1.1	1.3	0.4	0.4	-1.1	-0.8
Mn content in liver	0.4	0.5	1.1	0.4	0.6	0.6	0.7	0.7	-0.8	0.4	-1.1	-0.4	-0.2	-0.2	1.0	1.0
Na content in liver	0.6	0.6	2.1	1.1	0.9	-0.1	0.3	1.0	-0.4	-0.1	-0.1	0.5	-1.5	-1.5	0.3	0.4
Rb content in liver	0.2	0.3	0.8	-0.3	-0.3	-0.8	-0.6	-0.2	0.4	-0.8	0.8	0.9	-0.1	-0.1	-0.3	-0.0
Se content in liver	0.1	0.2	0.5	0.3	0.2	0.7	0.6	0.0	-0.2	0.6	-0.4	-0.5	-0.1	-0.1	-0.2	-0.6
Sr content in liver	2.2	1.9	2.8	-1.7	-1.6	-1.1	-1.3	-1.6	1.3	-1.3	1.2	0.9	1.7	1.7	-1.2	-1.0
Zn content in liver	0.4	0.5	1.6	-0.5	-0.5	0.3	0.0	-0.7	0.2	0.7	0.2	-0.6	1.3	1.3	-0.4	-0.7
Bone: minimum diameter	1.2	2.2	5.3	-1.8	-1.6	-2.3	-1.6	-1.3	1.2	-1.7	1.1	1.8	1.5	1.5	-0.6	-0.1
Time in familiar zone, hab. session 1	0.5	0.5	0.9	0.9	0.9	0.5	0.9	0.8	-0.9	0.4	-0.2	-0.8	-0.7	-0.7	0.5	0.2
Time in novel zone, hab. session 1	0.4	0.4	1.0	-0.9	-0.9	-0.1	-0.5	-0.9	0.7	0.1	0.1	0.2	1.0	1.0	-0.5	-0.4
Total zone transitions, hab. session 1	0.2	0.3	0.6	0.4	0.4	0.8	0.5	0.5	-0.5	0.6	-0.6	-0.4	-0.4	-0.4	0.5	0.5
Total locomotion distance, hab. session 1	0.8	1.2	2.2	0.8	1.0	1.4	1.2	1.1	-1.1	1.2	-1.5	-0.9	-0.7	-0.7	1.2	1.2
Locomotion velocity, hab. session 1	0.5	0.7	1.5	0.6	0.7	0.8	0.7	0.9	-0.7	0.6	-1.2	-0.2	-0.7	-0.7	1.0	1.2
Time in familiar zone, hab. session 2	3.5	3.7	5.5	2.3	2.2	2.3	2.0	2.0	-1.8	2.3	-1.7	-1.7	-1.9	-1.9	1.4	0.9
Time in novel zone, hab. session 2	6.5	6.6	9.4	-3.1	-3.0	-2.7	-2.5	-2.9	2.4	-2.6	2.3	1.9	2.9	2.9	-2.1	-1.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.3	-0.3	0.4	0.0	-0.3	0.1	0.4	0.1	-0.3	0.5	0.5	-0.2	-0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.5	-0.3	-0.2	0.6	0.3	-0.2	-0.2	0.6	-0.2	-0.5	0.7	0.7	0.1	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.2	-0.1	0.5	0.3	-0.1	-0.2	0.5	-0.2	-0.4	0.5	0.5	0.1	-0.0
Novel to familiar place preference ratio	0.2	0.2	0.7	0.5	0.5	0.5	0.4	0.5	-0.2	0.2	-0.8	-0.1	-0.6	-0.6	0.4	0.3
Novelty place preference	0.1	0.1	0.5	0.2	0.2	0.4	0.3	0.3	-0.1	0.1	-0.7	-0.0	-0.3	-0.3	0.3	0.3
Time in novel zone, NPP test	0.0	0.1	0.4	0.0	0.1	0.3	0.2	0.1	-0.1	0.0	-0.7	-0.0	-0.1	-0.1	0.2	0.2
Total zone transitions, NPP test	0.1	0.2	0.4	0.4	0.4	0.6	0.4	0.4	-0.2	0.6	-0.5	-0.2	-0.5	-0.5	0.2	0.1
Total locomotion distance, NPP test	0.6	0.8	1.3	1.0	0.9	1.1	1.0	0.9	-0.6	1.1	-1.0	-0.6	-1.0	-1.0	0.5	0.3
Locomotion velocity, NPP test	0.9	1.2	2.0	1.3	1.2	1.3	1.1	1.2	-0.8	1.2	-1.1	-0.7	-1.4	-1.4	0.7	0.4
Intraocular pressure	0.3	0.5	0.8	-0.6	-0.7	-0.9	-0.6	-0.9	0.6	-0.7	0.5	0.4	0.6	0.6	-0.8	-0.9
Delta distance traveled before/after self-admin	0.5	0.6	1.4	-0.3	-0.5	-0.9	-0.7	-0.6	1.1	-0.9	0.1	1.2	-0.3	-0.3	-1.0	-0.9
Delta ambulatory time before/after self-admin	0.2	0.2	0.7	0.6	0.4	0.1	0.3	0.3	-0.0	0.1	-0.7	0.1	-0.8	-0.8	0.0	-0.1
Parametrial fat weight	0.1	0.3	0.8	0.9	0.8	0.4	0.6	0.6	-0.6	0.5	-0.2	-0.5	-0.7	-0.7	0.2	0.1
Pavlov. Cond. lever latency	0.5	0.6	1.3	1.0	1.0	0.4	0.9	0.9	-1.1	0.7	0.0	-1.1	-0.5	-0.5	0.7	0.5
Pavlov. Cond. magazine entry latency	0.9	1.1	2.6	0.7	0.8	1.6	1.3	0.7	-1.0	1.4	-1.6	-1.3	-0.2	-0.2	0.9	0.6
Pavlov. Cond. change in total contacts	0.2	0.2	1.2	0.2	0.2	0.4	0.3	0.2	-0.0	0.3	-1.1	-0.1	-0.4	-0.4	0.3	0.2
Pavlov. Cond. index score	0.3	0.3	1.9	0.3	0.3	0.9	0.5	0.3	-0.2	0.7	-1.4	-0.2	-0.3	-0.3	0.4	0.3
Pavlov. Cond. latency score	0.2	0.2	1.5	0.0	0.0	0.8	0.3	0.1	0.0	0.5	-1.2	-0.0	-0.1	-0.1	0.2	0.2
Pavlov. Cond. lever contacts	0.3	0.3	0.9	-0.7	-0.7	-0.2	-0.7	-0.6	0.8	-0.5	-0.1	1.0	0.3	0.3	-0.4	-0.3
Pavlov. Cond. magazine entry number	1.3	1.6	3.1	-1.1	-1.2	-1.6	-1.5	-1.1	1.2	-1.6	1.8	1.3	0.7	0.7	-1.2	-0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	2.0	-0.4	-0.6	-0.5	-0.7	-0.7	0.7	-0.3	1.4	0.4	0.3	0.3	-1.0	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.5	0.2	0.2	0.6	0.4	0.2	-0.1	0.5	-1.2	-0.1	-0.2	-0.2	0.3	0.2
Pavlov. Cond. response bias	0.3	0.3	1.2	0.4	0.4	0.8	0.6	0.4	-0.4	0.6	-1.1	-0.5	-0.3	-0.3	0.5	0.3
Pavlov. Cond. lever latency	0.5	0.6	1.2	-0.6	-0.7	-0.8	-0.9	-0.8	0.9	-0.8	1.1	0.8	0.2	0.2	-1.0	-0.9
Pavlov. Cond. magazine entry latency	1.4	1.6	2.4	-1.3	-1.3	-1.5	-1.4	-1.3	1.3	-1.6	1.4	1.1	1.0	1.0	-1.2	-1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	-0.1	0.1	0.1	-0.2	-0.1	0.1	0.1	-0.1	-0.1
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	-0.1	0.0	-0.1	-0.2	-0.1	0.4	0.4	-0.0	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	-0.1	0.0	-0.1	-0.2	-0.1	0.3	0.3	0.0	0.0
Pavlov. Cond. lever contacts	0.9	1.2	2.1	1.0	1.1	1.1	1.2	1.2	-1.2	1.1	-1.4	-1.0	-0.6	-0.6	1.2	1.1
Pavlov. Cond. magazine entry number	1.8	2.2	3.0	1.7	1.7	1.5	1.5	1.6	-1.5	1.5	-1.4	-1.1	-1.6	-1.6	1.3	1.0
Pavlov. Cond. intertrial magazine entries	0.8	1.3	2.1	0.9	1.1	1.3	1.1	1.2	-1.2	1.4	-1.2	-0.9	-0.7	-0.7	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	-0.3	-0.3	-0.0	-0.1	-0.2	0.1	-0.1	-0.1	-0.1	0.4	0.4	-0.1	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	0.2	0.1	0.2	0.2	-0.2	0.1	-0.3	-0.2	-0.0	-0.0	0.3	0.3
Time in closed arm before self-admin	0.2	0.2	0.6	-0.6	-0.5	-0.4	-0.2	-0.5	0.2	-0.4	-0.2	0.1	0.8	0.8	-0.2	-0.3
Time in closed arm after self-admin	0.3	0.3	0.5	0.6	0.6	0.7	0.5	0.7	-0.6	0.7	-0.4	-0.7	-0.4	-0.4	0.5	0.5
Time in open arm before self-admin	0.2	0.2	0.4	-0.6	-0.5	-0.4	-0.5	-0.4	0.3	-0.4	0.7	0.3	0.6	0.6	-0.1	0.2
Time in open arm after self-admin	1.5	1.6	2.1	-1.3	-1.4	-1.4	-1.5	-1.4	1.4	-1.4	1.3	1.4	1.0	1.0	-1.2	-0.9
Bone: periosteal estimation	3.0	6.4	12.0	-2.9	-2.8	-3.5	-2.9	-2.5	2.4	-2.6	2.2	2.9	2.3	2.3	-1.8	-1.0
Bone: periosteal perimeter	3.3	5.6	8.9	-2.6	-2.6	-3.0	-2.8	-2.3	2.5	-2.8	2.0	2.9	1.8	1.8	-1.8	-1.2
Bone: post-yield work	0.5	0.7	2.3	0.6	0.6	1.0	1.0	0.6	-0.9	1.5	-1.0	-1.2	-0.1	-0.1	0.7	0.4
Progressive ratio test 1 active lever presses	0.6	0.7	1.4	-0.8	-0.9	-1.1	-0.8	-0.9	1.2	-1.1	0.0	1.1	0.5	0.5	-0.9	-0.9
Progressive ratio test 1 breakpoint	0.6	0.7	1.4	-0.7	-0.9	-1.0	-0.8	-0.9	1.2	-1.0	-0.0	1.1	0.4	0.4	-0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.4	-0.5	-0.5	-0.4	-0.5	0.5	-0.5	0.0	0.5	0.4	0.4	-0.4	-0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.7	0.2	0.0	-0.2	0.1	-0.0	0.3	-0.2	-0.8	0.4	-0.4	-0.4	-0.2	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	0.2	0.0	-0.2	0.0	-0.0	0.4	-0.2	-0.7	0.4	-0.4	-0.4	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.8	-0.5	-0.6	-0.8	-0.6	-0.6	0.9	-0.8	0.0	0.9	0.1	0.1	-0.7	-0.7
Incentive Sensitization - Responses	0.1	0.2	0.6	0.5	0.4	0.2	0.4	0.4	-0.1	0.2	-0.8	-0.0	-0.7	-0.7	0.2	0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.5	0.4	0.2	0.4	0.3	-0.1	0.2	-0.7	-0.0	-0.6	-0.6	0.1	0.0
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.5	0.5	0.3	0.2	0.2	0.3	0.2	0.2	-0.4	0.2	-0.7	-0.7	-0.1	-0.3
Progressive ratio	0.1	0.2	0.4	-0.4	-0.4	-0.6	-0.6	-0.3	0.4	-0.6	0.3	0.6	0.1	0.1	-0.5	-0.4
Food seeking constrained by brief footshock	1.0	1.2	1.9	-1.3	-1.3	-1.4	-1.3	-1.2	1.4	-1.4	0.2	1.2	0.5	0.5	-1.0	-0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.5	-0.2	-0.1	0.1	0.2	-0.1	-0.0	0.1	-0.7	-0.3	0.2	0.2	0.3	0.4
Retroperitoneal fat weight	0.4	1.6	3.0	-0.7	-1.0	-1.5	-1.5	-1.1	1.6	-1.4	1.3	1.7	-0.3	-0.3	-1.5	-1.4
Reaction time number correct	1.3	2.5	9.6	-2.1	-1.7	-0.7	-0.9	-1.6	0.5	-0.6	1.1	-0.2	3.1	3.1	-0.5	-0.4
Reaction time mean minus median	0.6	1.6	2.5	1.3	1.3	1.6	1.3	1.3	-1.3	1.5	-1.1	-1.4	-0.9	-0.9	1.2	1.0
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.1	-0.2	-0.1	-0.3	-0.2	0.4	-0.1	0.5	0.1	0.0	0.0	-0.4	-0.4
Reaction time num false alarms	1.0	1.4	3.1	-0.3	-0.7	-1.3	-1.2	-0.8	1.6	-1.3	1.2	1.8	-0.6	-0.6	-1.5	-1.5
Reaction time num false alarms AUC	1.4	2.1	4.0	-0.6	-1.1	-1.4	-1.6	-1.2	2.0	-1.5	1.6	2.0	-0.3	-0.3	-2.0	-1.9
Reaction time trials correct on left	1.3	2.5	9.6	-2.1	-1.7	-0.7	-0.9	-1.6	0.5	-0.6	1.1	-0.2	3.1	3.1	-0.5	-0.4
Reaction time trials on left	1.2	2.3	9.2	-2.0	-1.6	-0.6	-0.8	-1.6	0.5	-0.5	1.0	-0.3	3.0	3.0	-0.4	-0.3
Reaction time mean	1.1	1.8	2.9	1.7	1.6	1.1	1.3	1.6	-1.2	1.1	-1.2	-0.8	-1.7	-1.7	1.1	0.9
Reaction time mean AUC	1.0	1.7	2.8	1.7	1.5	1.1	1.2	1.6	-1.1	1.1	-1.1	-0.8	-1.7	-1.7	1.0	0.8
Median of all reaction times	1.1	1.5	3.0	1.6	1.5	0.8	1.1	1.6	-1.0	0.8	-1.1	-0.5	-1.7	-1.7	0.9	0.8
Reaction time omissions	0.4	0.6	1.5	0.9	0.8	1.2	1.0	0.7	-0.7	1.0	-0.7	-1.0	-0.6	-0.6	0.4	-0.0
Reaction time false alarm rate	1.1	1.6	3.3	0.4	-0.2	-1.0	-1.0	-0.4	1.5	-1.2	0.9	1.8	-1.6	-1.6	-1.6	-1.6
Reaction time premature initiation rate	0.1	0.1	0.4	0.1	-0.1	-0.3	-0.1	-0.2	0.4	-0.0	0.4	0.1	-0.1	-0.1	-0.5	-0.6
Reaction time premature initiations	0.4	0.7	2.1	-0.9	-0.9	-0.6	-0.5	-1.0	0.6	-0.3	0.9	-0.0	1.4	1.4	-0.7	-0.8
Std. dev. reaction times	0.5	1.0	1.7	1.3	1.2	1.2	1.0	1.1	-0.8	1.2	-0.8	-0.9	-1.1	-1.1	0.7	0.4
Reaction time trials completed	1.2	2.3	9.2	-2.0	-1.6	-0.6	-0.8	-1.6	0.5	-0.5	1.0	-0.3	3.0	3.0	-0.4	-0.3
Reaction time trials AUC	1.2	2.3	9.2	-1.9	-1.6	-0.5	-0.7	-1.5	0.4	-0.5	0.9	-0.3	3.0	3.0	-0.3	-0.3
Run reversals in cocaine runway, females	1.8	1.8	5.3	2.0	1.6	1.0	1.0	1.5	-0.7	1.0	-1.0	-0.3	-2.3	-2.3	0.4	0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.4	-0.5	-0.6	-0.4	-0.5	0.6	-0.6	-0.1	0.3	0.1	0.1	-0.4	-0.4
Latency to leave start box in cocaine runway	1.3	1.5	5.1	-0.8	-1.0	-1.2	-1.6	-0.9	1.3	-1.2	2.3	1.5	0.5	0.5	-1.4	-1.1
Latency to leave start box in cocaine runway, F	2.4	2.8	5.6	-1.4	-1.6	-1.7	-2.0	-1.6	1.9	-1.7	2.4	1.9	0.9	0.9	-1.7	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	1.2	0.1	0.1	0.0	-0.3	0.1	-0.1	0.0	1.1	0.2	0.1	0.1	-0.2	-0.3
Std. dev. time between licks in bursts	0.3	0.3	1.4	0.1	0.3	0.3	0.4	0.5	-0.7	0.5	-0.6	-0.4	0.2	0.2	1.0	1.2
Total sessions with >9 infusions	0.1	0.1	0.2	-0.1	-0.2	-0.4	-0.2	-0.2	0.4	-0.4	-0.2	0.5	-0.2	-0.2	-0.3	-0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.3	-0.3	0.1	-0.2	0.6	0.1	0.3	0.3	-0.2	-0.1
Short access day 10 total inactive lever presses	0.4	0.9	2.3	0.2	0.6	1.1	1.0	0.7	-1.4	1.1	-0.6	-1.5	0.4	0.4	1.2	1.2
Short access day 1 total infusions	0.1	0.1	0.2	0.2	0.0	-0.2	-0.1	-0.0	0.3	-0.2	-0.2	0.4	-0.4	-0.4	-0.2	-0.3
Short access day 10 total infusions	0.1	0.1	0.9	-0.1	-0.1	-0.1	0.2	-0.1	0.0	-0.1	-1.0	0.0	0.2	0.2	0.1	-0.0
Short access total infusions	0.0	0.1	0.7	0.0	0.0	-0.0	0.2	-0.0	0.0	-0.0	-0.8	0.0	-0.0	-0.0	0.1	-0.0
Short access day 1 locomotion	0.3	0.3	0.6	-0.6	-0.6	-0.7	-0.6	-0.7	0.8	-0.7	0.0	0.8	0.3	0.3	-0.6	-0.5
Short access day 10 total locomotion	1.1	1.9	2.9	1.3	1.4	1.6	1.6	1.4	-1.7	1.6	-1.2	-1.7	-0.7	-0.7	1.5	1.2
Short access total locomotion	0.4	0.5	0.8	0.7	0.7	0.8	0.9	0.7	-0.8	0.8	-0.8	-0.8	-0.4	-0.4	0.7	0.6
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.2	-0.3	0.1	-0.2	0.2	0.0	0.4	0.4	-0.1	-0.0
Compulsive drug intake	0.1	0.1	0.2	0.4	0.4	0.4	0.2	0.4	-0.4	0.4	0.4	-0.3	-0.4	-0.4	0.2	0.2
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.1	-0.2	0.1	-0.2	-0.1	0.1	0.2	0.2	-0.1	-0.1
Social response proportion	1.1	1.2	2.7	0.7	0.9	1.5	1.4	0.8	-1.4	1.3	-1.1	-1.6	0.1	0.1	1.3	1.0
Social responses	0.4	0.5	2.1	-0.8	-0.5	0.0	0.0	-0.6	-0.2	0.0	0.2	-0.6	1.4	1.4	0.2	0.1
Social time	1.1	1.5	2.0	1.2	1.3	1.2	1.3	1.2	-1.4	1.2	-1.3	-1.2	-1.0	-1.0	1.2	1.0
Soleus weight	3.0	8.9	15.5	-3.6	-3.4	-2.4	-2.8	-3.4	2.5	-2.2	3.1	1.5	3.9	3.9	-2.5	-2.3
Bone: stiffness	0.8	1.3	3.8	-0.9	-0.9	-1.9	-1.4	-0.7	1.2	-1.5	1.0	1.9	0.1	0.1	-0.8	-0.2
Tibialis anterior weight	1.3	4.5	6.2	-2.4	-2.5	-1.6	-2.3	-2.5	2.3	-1.5	2.3	1.5	2.1	2.1	-2.2	-2.0
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.3	1.1	1.0	0.8	0.8	0.9	-0.6	0.8	-0.2	-0.5	-1.1	-1.1	0.4	0.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	0.9	0.8	0.8	0.6	0.7	-0.6	0.8	-0.5	-0.6	-0.8	-0.8	0.3	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.5	-0.4	-0.3	-0.2	-0.3	0.2	-0.3	0.3	0.1	0.7	0.7	-0.3	-0.2
Time to tail flick, test, after self-admin	0.7	0.7	2.7	-1.3	-1.0	-0.6	-0.4	-0.9	0.3	-0.6	-0.0	0.2	1.6	1.6	-0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.5	-0.4	-0.3	-0.4	-0.4	0.2	-0.3	-0.1	0.2	0.3	0.3	-0.2	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	-0.5	-0.3	-0.0	0.2	-0.3	-0.2	-0.0	-0.7	-0.3	0.8	0.8	0.4	0.3
Tibia length	1.3	3.5	10.4	-1.6	-1.6	-3.2	-2.1	-1.4	1.7	-2.5	1.6	2.9	0.9	0.9	-1.2	-0.8
Ambulatory time before self-admin	0.7	1.1	2.2	1.4	1.3	1.0	0.6	1.3	-0.8	1.0	0.1	-0.7	-1.5	-1.5	0.5	0.5
Ambulatory time after self-admin	1.4	1.6	4.4	1.8	1.5	1.0	0.9	1.5	-0.8	1.0	-0.7	-0.5	-2.1	-2.1	0.5	0.3
Bone: tissue strength	2.4	2.4	6.3	-2.1	-1.8	-1.3	-1.2	-1.7	0.8	-1.4	1.3	0.8	2.5	2.5	-0.6	-0.4
Total heroin consumption	0.5	0.6	1.0	-0.9	-0.9	-0.5	-0.9	-0.8	0.7	-0.5	1.0	0.4	1.0	1.0	-0.6	-0.5
Bone: trabecular number	0.4	0.6	1.5	0.8	0.8	0.7	1.1	0.7	-0.7	0.8	-1.2	-0.8	-0.5	-0.5	0.6	0.3
Bone: trabecular spacing	1.5	2.0	3.4	-1.6	-1.5	-1.8	-1.5	-1.3	1.2	-1.8	1.2	1.5	1.4	1.4	-0.9	-0.5
Bone: trabecular thickness	1.5	1.9	4.3	1.2	1.2	1.7	1.4	1.2	-1.1	2.1	-1.8	-1.5	-1.0	-1.0	1.1	0.8
Bone: trabecular tissue density	0.3	0.4	0.8	0.7	0.7	0.3	0.6	0.8	-0.6	0.3	-0.8	-0.1	-0.9	-0.9	0.7	0.7
Water consumed over 24 hours	1.0	1.3	2.8	0.3	0.7	0.9	1.2	0.8	-1.6	0.9	-1.1	-1.6	0.6	0.6	1.7	1.6
Number of responses in last shaping day	0.5	0.5	2.3	1.0	0.6	0.0	0.1	0.4	0.3	0.0	-0.4	0.6	-1.5	-1.5	-0.3	-0.5