Hub : Genes

Sf3a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Sf3a2 0.1 0.08 6.8e-06 0.07 0.08 0.09 0.08 1.0e-04 6.8e-05 1.3e-05 5.3e-05
2 NAcc mRNA stability Sf3a2 0.06 0.05 6.2e-09 0.04 0.05 0.05 0.05 4.8e-07 1.4e-08 1.3e-07 3.6e-08
3 Brain mRNA stability Sf3a2 0.1 0.06 1.2e-10 0.11 0.1 0.1 0.1 1.9e-10 3.0e-09 2.7e-09 1.4e-09
4 Brain intron excision ratio chr7_9563765_9566161 0.03 0.02 4.7e-03 0.01 0.02 0.01 0.01 2.0e-02 9.8e-03 1.5e-02 4.3e-02
5 Adipose gene expression Sf3a2 0.04 0.03 6.8e-06 0.04 0.04 0.04 0.04 8.7e-06 1.7e-05 1.4e-05 9.8e-06
6 PL mRNA stability Sf3a2 0.11 0.07 9.8e-15 0.14 0.14 0.14 0.14 8.0e-15 4.4e-15 1.3e-14 3.7e-15
7 Brain gene expression Sf3a2 0.11 0.06 2.5e-12 0.12 0.12 0.13 0.12 1.5e-11 1.8e-11 8.0e-12 1.3e-11
8 IC gene expression Sf3a2 0.08 0.06 1.9e-03 0.04 0.03 0.01 0.02 8.1e-03 2.7e-02 1.5e-01 4.6e-02
9 LHb mRNA stability Sf3a2 0.13 0.1 4.1e-03 0.1 0.1 0.09 0.09 2.5e-03 2.0e-03 3.1e-03 3.9e-03
10 PL gene expression Sf3a2 0.04 0.03 2.0e-05 0.04 0.04 0.04 0.04 1.3e-05 1.1e-05 3.2e-05 2.0e-05
11 Liver mRNA stability Sf3a2 0.02 0.02 9.1e-03 0 0.01 0 0 1.3e-01 2.1e-02 7.3e-02 1.1e-01
12 NAcc intron excision ratio chr7_9563765_9566161 0.01 0.01 9.5e-03 0.01 0.01 0.01 0.01 1.8e-02 4.3e-03 2.6e-03 3.9e-03
13 NAcc gene expression Sf3a2 0.03 0.02 8.7e-05 0.02 0.02 0.02 0.01 4.8e-04 7.5e-04 3.5e-04 2.1e-03
14 pVTA mRNA stability Sf3a2 0.04 0.04 2.3e-03 0 0.01 0.01 0.01 2.9e-01 5.9e-02 2.4e-02 7.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.13.20.10.20.7-0.5-0.70.9-0.7-0.71.1-1.31.5-1.8-1.71.3
Area under the delay curve2.02.43.01.61.61.7-1.6-1.61.5-1.5-1.71.6-1.51.5-1.0-1.21.7
BMI with tail5.217.825.25.04.94.6-4.8-4.64.4-4.7-4.64.2-3.93.6-3.1-3.32.3
BMI without tail1.44.37.02.62.62.3-2.4-2.32.2-2.4-2.22.0-1.81.6-1.1-1.21.5
Body weight0.73.24.42.12.02.0-2.0-2.01.9-2.0-1.91.8-1.71.5-1.4-1.40.8
Weight adjusted by age0.10.20.40.70.70.4-0.5-0.50.4-0.5-0.40.2-0.10.0-0.10.00.3
Bone surface0.61.23.8-0.6-0.40.30.0-0.40.6-0.3-0.31.0-1.31.6-1.9-1.81.6
Bone volume0.71.23.6-0.6-0.40.3-0.0-0.40.6-0.3-0.31.1-1.41.7-1.9-1.81.7
Breakpoint value in progressive ratio session4.14.96.3-2.2-2.2-2.32.22.2-2.42.22.1-2.22.2-2.12.52.2-1.9
Number of licking bursts0.10.20.60.20.1-0.20.10.2-0.30.20.2-0.50.6-0.70.80.8-0.7
Context. condit. distance diff. score0.30.30.60.70.70.6-0.7-0.60.5-0.7-0.60.6-0.50.5-0.2-0.30.7
Locomotion velocity, session 10.20.20.8-0.9-0.7-0.40.50.5-0.00.40.4-0.1-0.10.2-0.4-0.40.1
Locomotion distance, session 10.40.52.4-0.5-0.40.10.1-0.10.3-0.1-0.10.6-0.80.9-1.5-1.40.1
Locomotion velocity, session 21.72.05.0-2.2-2.1-1.51.81.6-1.41.71.5-1.10.8-0.5-0.10.0-1.0
Locomotion distance, session 20.71.02.7-1.6-1.6-1.01.21.0-0.81.11.0-0.50.20.0-0.8-0.7-0.9
Locomotion velocity, session 35.66.37.4-2.7-2.7-2.62.72.7-2.52.72.6-2.62.5-2.42.22.3-1.9
Locomotion distance, session 30.00.00.1-0.00.0-0.00.00.1-0.20.00.0-0.10.2-0.20.40.30.1
Stereotopy head waving bouts, day 33.44.06.1-2.4-2.5-2.22.32.2-2.02.42.2-1.91.7-1.61.11.2-1.6
Stereotopy head waving duration, day 34.65.47.7-2.7-2.7-2.52.72.5-2.42.82.5-2.32.1-2.01.51.7-1.7
Locomotion velocity, session 70.50.60.8-0.9-0.7-0.80.80.8-0.90.70.8-0.70.7-0.60.90.90.7
Locomotion distance, session 70.10.10.50.40.40.1-0.3-0.1-0.3-0.2-0.1-0.10.2-0.30.70.60.2
Stereotopy head waving bouts, day 70.30.41.00.00.10.4-0.2-0.40.5-0.2-0.40.7-0.80.9-1.0-1.00.9
Stereotopy head waving duration, day 70.20.20.5-0.6-0.5-0.20.40.20.00.30.20.2-0.30.5-0.7-0.60.6
Locomotion velocity, session 80.20.30.9-0.8-0.7-0.30.50.3-0.30.40.30.1-0.30.5-1.0-0.80.4
Locomotion distance, session 80.10.10.2-0.4-0.4-0.20.30.2-0.10.20.2-0.0-0.10.2-0.4-0.4-0.2
Degree of sensitization distance0.40.40.50.70.70.7-0.7-0.70.5-0.7-0.70.6-0.60.6-0.5-0.50.6
Degree of sensitization stereotypy2.32.53.01.31.41.6-1.5-1.51.6-1.5-1.61.7-1.71.7-1.6-1.71.7
Conditioned locomotion0.60.61.81.31.20.9-1.1-1.00.8-0.9-0.90.5-0.40.20.10.00.1
Cocaine response after cond. corrected2.93.56.92.62.62.1-2.3-2.11.9-2.1-2.11.6-1.41.1-0.4-0.71.3
Cocaine response after cond. not corrected3.13.67.42.72.62.2-2.4-2.22.0-2.2-2.21.6-1.41.1-0.4-0.61.3
Cocaine response before conditioning0.30.40.6-0.8-0.8-0.70.70.7-0.60.70.7-0.60.5-0.40.60.6-0.1
Saline control response0.10.10.20.40.40.2-0.3-0.10.2-0.2-0.20.10.0-0.10.50.3-0.3
Bone: connectivity density0.81.32.90.50.61.0-0.8-1.01.0-0.9-1.01.2-1.41.5-1.7-1.61.2
Bone: cortical apparent density0.81.11.51.11.11.1-1.1-1.11.2-1.1-1.11.1-1.11.0-0.7-0.80.9
Bone: cortical area0.81.32.50.60.81.0-0.9-1.01.2-1.0-1.01.2-1.31.4-1.3-1.31.6
Bone: cortical porosity0.10.10.2-0.5-0.4-0.20.30.2-0.10.20.2-0.0-0.10.2-0.5-0.40.2
Bone: cortical porosity0.30.31.2-0.2-0.10.2-0.1-0.20.4-0.2-0.20.5-0.60.8-1.1-1.00.6
Bone: cortical thickness1.32.12.61.21.31.5-1.4-1.41.6-1.5-1.51.6-1.61.6-1.5-1.51.4
Bone: cortical thickness0.30.31.0-0.1-0.1-0.40.30.4-0.40.40.4-0.60.7-0.81.01.0-0.3
Bone: cortical tissue density0.60.71.00.90.90.9-0.9-0.91.0-0.9-0.90.9-0.90.8-0.6-0.70.8
Condit. Reinf. active minus inactive responses3.54.05.1-2.3-2.2-2.12.22.2-2.02.22.1-2.01.9-1.81.51.6-1.6
Condit. Reinf. active-inactive response ratio2.52.63.0-1.5-1.5-1.61.61.7-1.61.61.6-1.71.7-1.71.71.7-1.4
Condit. Reinf. active responses2.32.95.1-2.3-2.2-1.92.01.9-1.62.01.9-1.61.4-1.20.70.8-1.5
Condit. Reinf. inactive responses0.30.41.2-1.1-1.0-0.60.80.6-0.40.60.6-0.20.00.1-0.7-0.5-0.3
Incentive salience index mean1.41.73.0-1.7-1.7-1.41.61.5-1.31.51.4-1.21.0-0.90.50.6-1.1
Condit. Reinf. lever presses0.40.52.1-0.2-0.20.3-0.1-0.20.4-0.3-0.30.7-0.91.0-1.5-1.40.1
Condit. Reinf. active minus inactive responses3.03.84.7-1.7-1.8-1.91.92.1-2.01.91.9-2.12.1-2.12.22.1-1.5
Condit. Reinf. active-inactive response ratio0.60.71.4-0.2-0.3-0.60.50.7-0.70.60.6-0.91.0-1.11.11.1-1.2
Condit. Reinf. active responses2.53.44.1-1.9-1.8-1.91.92.0-1.91.91.9-1.91.9-1.82.01.9-0.9
Condit. Reinf. inactive responses1.01.21.8-1.3-1.2-1.21.21.2-1.11.21.2-1.01.0-0.91.31.2-0.1
Condit. Reinf. lever presses2.33.14.3-1.6-1.6-1.81.71.8-1.81.81.8-1.81.8-1.82.12.0-1.0
Condit. Reinf. lever reinforcers received2.13.04.5-1.6-1.5-1.71.71.8-1.81.71.7-1.81.8-1.82.12.0-0.9
Conditioned reinforcement - actives1.32.23.0-1.3-1.3-1.61.41.5-1.61.21.5-1.61.7-1.71.31.5-1.3
Conditioned reinforcement - inactives0.00.00.10.20.1-0.1-0.00.1-0.1-0.1-0.0-0.20.2-0.30.20.2-0.2
Conditioned locomotion7.09.111.6-3.4-3.3-3.33.33.4-3.33.03.1-3.02.9-2.72.42.4-2.1
Patch foraging indifference point 0 sec0.20.40.50.50.50.5-0.6-0.60.7-0.6-0.50.7-0.70.7-0.6-0.60.7
Patch foraging indifference point AUC1.01.52.2-1.2-1.2-1.21.21.3-1.31.21.2-1.31.2-1.21.01.0-1.5
Delay disc. indifference point, 0s delay10.010.913.42.92.93.2-3.1-3.23.3-3.3-3.33.5-3.63.6-3.7-3.62.9
Delay disc. indifference point, 16s delay0.20.20.60.50.50.6-0.5-0.50.5-0.4-0.50.5-0.50.5-0.2-0.40.8
Delay disc. indifference point, 2s delay6.87.58.52.72.72.8-2.8-2.82.8-2.8-2.82.9-2.82.8-2.2-2.42.9
Delay disc. indifference point, 24s delay0.40.40.70.80.80.9-0.7-0.70.5-0.7-0.70.5-0.50.4-0.1-0.30.8
Delay disc. indifference point, 4s delay1.92.04.41.31.31.5-1.3-1.41.4-1.2-1.41.5-1.51.5-1.1-1.32.1
Delay disc. indifference point, 8s delay0.70.91.51.21.21.1-1.1-1.00.9-1.0-1.10.9-0.80.7-0.4-0.50.8
Indifference point function ln k0.10.21.10.50.50.4-0.4-0.40.4-0.4-0.40.3-0.30.30.1-0.01.1
Indifference point function log k0.10.21.10.50.50.4-0.4-0.40.4-0.4-0.40.3-0.30.30.1-0.01.1
Patch foraging total patch changes 0 sec0.20.30.40.50.50.5-0.5-0.60.6-0.5-0.50.6-0.60.6-0.5-0.50.6
Patch foraging total patch changes 12 sec0.20.20.50.70.60.5-0.6-0.40.5-0.5-0.50.3-0.20.1-0.1-0.1-0.4
Patch foraging total patch changes 18 sec0.61.01.3-1.1-1.1-1.11.11.1-1.01.11.1-1.00.9-0.80.60.8-0.9
Patch foraging total patch changes 24 sec0.00.10.3-0.3-0.3-0.30.30.2-0.20.20.3-0.20.2-0.10.20.2-0.6
Patch foraging total patch changes 6 sec0.10.20.4-0.6-0.6-0.50.50.5-0.30.40.5-0.30.3-0.2-0.2-0.0-0.5
Patch foraging time to switch 0 sec1.83.76.51.31.41.9-1.6-1.82.1-1.7-1.72.1-2.22.2-2.5-2.51.2
Patch foraging water rate 0 sec0.30.72.40.0-0.0-0.60.30.6-0.80.40.5-0.91.1-1.21.51.4-0.2
Patch foraging water rate 12 sec0.30.51.81.31.20.7-1.0-0.70.5-0.8-0.80.3-0.1-0.10.60.50.3
Patch foraging water rate 18 sec1.42.27.2-0.0-0.2-1.10.61.0-1.20.90.9-1.61.8-2.12.72.5-1.2
Patch foraging water rate 24 sec0.50.72.60.80.6-0.1-0.30.2-0.4-0.0-0.0-0.70.9-1.21.61.5-0.6
Patch foraging water rate 6 sec1.31.84.9-0.6-0.6-1.10.91.1-1.41.11.1-1.51.6-1.72.22.1-0.8
Seeking ratio, delayed vs. immediate footshock3.24.05.6-2.4-2.3-2.12.22.2-2.32.12.1-1.91.7-1.61.91.7-1.0
Distance traveled before self-admin0.20.20.60.20.30.4-0.4-0.20.3-0.6-0.60.5-0.50.5-0.3-0.50.8
Distance traveled after self-admin0.00.00.1-0.2-0.2-0.10.20.3-0.20.00.1-0.10.1-0.10.30.10.1
Extensor digitorum longus weight3.011.818.34.34.33.9-4.1-3.73.5-3.9-3.93.3-3.02.7-1.9-2.32.3
Bone: elastic displacement0.10.20.3-0.5-0.5-0.40.50.4-0.50.40.4-0.40.4-0.30.10.2-0.2
Bone: elastic work0.40.51.70.50.60.7-0.6-0.70.7-0.7-0.70.7-0.80.8-0.6-0.61.3
Bone: endosteal estimation0.30.61.10.60.70.7-0.7-0.70.8-0.7-0.70.8-0.80.9-0.7-0.81.0
Bone: endosteal perimeter0.10.20.7-0.8-0.7-0.50.60.5-0.40.60.5-0.30.2-0.1-0.00.00.4
Epididymis fat weight0.10.31.00.20.1-0.30.10.2-0.30.30.1-0.50.6-0.81.00.9-1.0
Delta time in closed arm before/after self-admin0.40.41.50.80.70.1-0.4-0.20.0-0.3-0.2-0.30.6-0.81.21.0-0.7
Delta time in open arm before/after self-admin0.60.60.90.80.80.9-0.8-0.80.8-0.7-0.90.8-0.80.7-0.7-0.70.6
Diff in mean of infusions in LGA sessions1.41.82.3-1.5-1.4-1.31.41.3-1.51.51.2-1.31.2-1.11.41.2-1.1
Delay discount exponential model param1.71.92.7-1.5-1.5-1.61.51.4-1.31.31.5-1.41.3-1.30.81.0-1.6
Extinction: sum of active levers before priming1.51.62.4-0.9-1.1-1.41.11.3-1.31.11.2-1.31.4-1.41.61.4-1.5
Active lever presses in extinction session 62.02.03.0-1.7-1.7-1.71.61.6-1.61.41.5-1.41.3-1.21.10.9-0.8
Bone: final force1.82.84.01.31.51.6-1.5-1.61.8-1.6-1.61.8-1.81.9-1.6-1.62.0
Bone: final moment1.52.33.41.11.31.5-1.4-1.41.6-1.5-1.51.6-1.71.7-1.5-1.51.8
Food consumed during 24 hour testing period0.40.50.80.90.90.8-0.8-0.80.7-0.8-0.80.7-0.60.6-0.1-0.30.8
Glucose2.03.24.42.02.12.0-2.0-1.81.8-2.0-2.01.8-1.61.5-1.1-1.31.6
Heart weight1.01.63.0-0.7-0.8-1.11.01.1-1.21.21.1-1.41.5-1.51.71.6-1.1
Delay discount hyperbolic model param3.13.44.9-1.9-2.0-2.01.91.9-1.91.82.0-1.91.8-1.81.21.4-2.2
Intermittent access intake day 1-15 change3.87.78.6-2.6-2.7-2.92.82.9-2.92.72.9-2.92.9-2.92.62.7-2.3
Intermittent access intake escalation3.36.87.6-2.5-2.5-2.72.62.7-2.82.62.7-2.72.7-2.72.52.5-2.1
Intermittent access intake escalation 25.15.86.5-2.4-2.4-2.52.42.5-2.52.42.5-2.52.5-2.42.32.4-1.9
Intermitt. access day 1 inactive lever presses0.31.02.7-0.4-0.4-0.80.60.9-1.10.60.7-1.11.3-1.41.61.3-0.9
Intermitt. access day 15 inactive lever presses0.10.30.5-0.7-0.7-0.60.60.6-0.60.60.6-0.50.5-0.50.20.3-0.5
Intermitt. access escalation Index1.21.63.00.90.91.2-1.1-1.11.3-1.2-1.11.4-1.41.5-1.7-1.51.2
Intermittent access day 1 total infusions0.20.40.7-0.3-0.3-0.60.50.6-0.60.50.4-0.70.8-0.80.80.8-0.3
Intermittent access day 15 total infusions2.84.15.0-1.9-2.0-2.22.12.1-2.22.02.0-2.22.2-2.12.02.0-1.3
Intermittent access terminal intake (last 3 days)2.02.73.5-1.6-1.6-1.91.71.7-1.81.61.6-1.71.7-1.71.51.5-0.9
Intermittent access total infusions1.11.41.8-1.1-1.1-1.41.21.3-1.31.11.1-1.31.3-1.31.01.1-0.7
Intermittent access day 1 locomotion2.12.73.5-1.3-1.3-1.71.51.6-1.71.51.5-1.81.8-1.91.91.8-1.5
Intermittent access day 15 total locomotion3.56.37.2-2.4-2.4-2.62.52.7-2.72.42.5-2.72.7-2.62.12.2-2.5
Intermittent access total locomotion2.93.54.1-1.7-1.8-2.01.92.0-2.01.71.8-2.02.0-2.01.81.8-1.6
Intermittent access standard deviation3.57.29.0-3.0-2.9-3.02.93.0-2.92.72.8-2.82.7-2.52.12.1-1.8
Left kidney weight0.00.20.70.10.1-0.20.00.2-0.30.10.2-0.40.5-0.60.90.8-0.4
Right kidney weight0.62.94.4-1.4-1.3-1.71.51.6-1.71.61.6-1.81.9-1.92.12.1-1.3
Cocaine induced anxiety0.50.71.9-1.4-1.3-0.91.10.9-0.80.91.0-0.60.4-0.3-0.10.0-0.6
Post-drug Anxiety0.40.51.5-1.2-1.1-0.70.90.7-0.60.90.7-0.40.2-0.0-0.0-0.1-0.4
Baseline Anxiety0.10.10.6-0.3-0.2-0.30.30.3-0.30.30.1-0.30.3-0.30.80.50.3
Tail length3.212.614.7-3.8-3.7-3.83.83.8-3.73.73.8-3.63.5-3.43.23.4-1.9
Length with tail1.87.99.2-3.0-3.0-3.03.03.0-2.93.03.0-2.92.8-2.72.42.6-2.0
Length without tail0.00.00.00.10.10.0-0.1-0.0-0.0-0.1-0.10.0-0.0-0.00.00.0-0.1
Times rat made contact with spout0.10.10.20.50.50.2-0.3-0.20.2-0.2-0.20.00.1-0.10.40.3-0.1
Lifetime Intake0.60.81.2-0.8-0.8-1.10.91.0-1.00.80.8-1.01.0-1.00.80.8-0.5
Liver weight, left0.81.32.01.41.31.2-1.3-1.21.2-1.2-1.31.1-1.00.9-0.7-0.80.7
Liver weight, right0.30.61.11.01.00.8-0.9-0.80.7-0.9-0.90.7-0.50.5-0.0-0.20.7
Locomotor activity2.03.15.8-2.4-2.3-2.02.22.0-1.92.02.0-1.61.4-1.11.01.1-0.9
Locomotor testing distance1.12.03.7-1.9-1.9-1.61.71.6-1.41.51.6-1.21.1-0.91.00.9-0.6
Locomotor testing rearing0.10.20.9-0.1-0.2-0.30.30.4-0.40.40.3-0.40.5-0.50.90.8-0.1
Locomotion in novel chamber1.51.93.2-1.2-1.3-1.31.31.4-1.41.21.3-1.41.4-1.41.41.2-1.8
Locomotion in novel chamber post-restriction1.11.83.4-1.3-1.3-1.31.41.3-1.21.41.4-1.31.3-1.31.91.7-0.3
Fecal boli incidents, locomotor time 10.91.32.11.21.31.2-1.3-1.21.3-1.4-1.31.1-1.00.9-0.8-0.9-0.4
Change in fecal boli incidents, locomotor task0.30.32.8-0.6-0.5-0.50.50.4-0.40.30.4-0.20.10.00.20.31.7
Time >=10cm from walls, locomotor time 10.70.81.90.30.50.7-0.6-0.50.7-0.9-0.60.9-1.01.1-1.4-1.30.9
Bouts of movement, locomotor time 10.40.40.5-0.6-0.6-0.70.60.7-0.70.60.7-0.70.7-0.70.50.6-0.5
Total resting periods, locomotor time 10.40.40.6-0.7-0.7-0.70.70.8-0.70.70.7-0.70.7-0.70.60.6-0.3
Rest time, locomotor task time 10.10.20.4-0.7-0.5-0.50.50.6-0.40.30.4-0.30.3-0.20.10.2-0.0
Distance moved, locomotor task time 11.01.53.20.90.81.1-1.0-1.11.1-1.1-1.01.3-1.41.4-1.6-1.51.8
Vertical activity count, locomotor time 10.10.21.10.50.50.3-0.4-0.30.3-0.4-0.30.2-0.20.20.20.11.1
Time >=10cm from walls, locomotor time 20.50.71.21.11.10.9-1.1-0.80.8-1.1-0.90.8-0.70.6-0.2-0.40.6
Bouts of movement, locomotor time 20.10.20.7-0.7-0.6-0.30.40.4-0.20.40.3-0.1-0.00.2-0.9-0.6-0.2
Total resting periods, locomotor time 20.10.21.0-0.6-0.5-0.20.40.3-0.20.40.30.0-0.10.3-1.0-0.8-0.1
Rest time, locomotor task time 20.30.40.8-0.9-0.9-0.60.80.7-0.60.70.7-0.50.4-0.3-0.00.1-0.3
Distance moved, locomotor task time 20.40.50.91.00.90.7-0.8-0.70.7-0.8-0.70.6-0.50.4-0.5-0.50.1
Vertical activity count, locomotor time 20.20.20.60.80.80.5-0.7-0.50.5-0.6-0.50.2-0.1-0.00.20.2-0.2
Light reinforcement 13.17.711.3-3.4-3.3-2.93.23.0-2.93.13.1-2.62.4-2.21.82.0-2.3
Light reinforcement 21.21.93.0-1.7-1.7-1.51.61.5-1.41.51.5-1.31.2-1.00.80.9-1.1
Bone: marrow area0.30.61.00.60.70.7-0.7-0.70.8-0.7-0.70.8-0.80.9-0.7-0.71.0
Bone: maximum diameter0.40.72.0-1.4-1.3-1.01.11.0-0.81.01.0-0.60.5-0.30.20.20.1
Bone: maximum force1.52.74.01.41.51.6-1.6-1.61.8-1.6-1.61.7-1.71.8-1.4-1.52.0
Bone: maximum moment1.32.33.41.21.41.5-1.5-1.51.7-1.5-1.51.6-1.61.6-1.3-1.41.9
Mean time between licks in bursts2.56.06.8-2.5-2.6-2.62.62.6-2.62.62.6-2.52.4-2.41.92.1-2.3
Mean num. licks in bursts0.10.10.40.10.20.3-0.3-0.30.4-0.3-0.30.4-0.40.5-0.3-0.40.6
Cd content in liver0.10.20.3-0.5-0.5-0.40.50.4-0.40.40.4-0.30.3-0.30.20.2-0.4
Co content in liver1.82.12.4-1.4-1.5-1.51.51.5-1.61.51.5-1.51.5-1.51.31.4-1.3
Cu content in liver0.10.10.4-0.6-0.5-0.20.30.3-0.20.20.20.0-0.20.3-0.6-0.50.2
Fe content in liver0.20.30.5-0.3-0.4-0.50.40.5-0.50.50.5-0.60.6-0.60.40.4-0.7
K content in liver0.10.10.4-0.2-0.20.10.0-0.00.1-0.1-0.10.3-0.40.5-0.7-0.60.1
Mg content in liver0.20.20.4-0.6-0.6-0.50.50.5-0.50.50.5-0.30.2-0.2-0.00.0-0.4
Mn content in liver0.60.62.0-1.4-1.2-0.81.00.8-0.70.80.8-0.30.10.1-0.7-0.40.5
Na content in liver1.51.63.10.90.91.2-1.1-1.11.2-1.2-1.21.3-1.41.5-1.8-1.70.7
Rb content in liver0.20.20.7-0.2-0.10.2-0.1-0.20.3-0.2-0.20.5-0.60.8-0.9-0.80.7
Se content in liver0.20.20.3-0.5-0.5-0.50.50.5-0.50.50.5-0.50.5-0.50.20.3-0.6
Sr content in liver0.00.00.10.10.1-0.0-0.00.0-0.10.00.0-0.10.2-0.20.30.3-0.2
Zn content in liver5.96.58.2-2.1-2.1-2.42.32.5-2.62.52.4-2.72.8-2.92.82.8-2.6
Bone: minimum diameter0.10.20.80.00.10.3-0.2-0.30.4-0.3-0.30.5-0.50.6-0.5-0.50.9
Time in familiar zone, hab. session 12.42.32.8-1.4-1.4-1.51.51.4-1.71.71.5-1.61.6-1.61.61.7-0.9
Time in novel zone, hab. session 11.71.72.50.91.01.2-1.1-1.11.3-1.3-1.21.4-1.41.5-1.5-1.51.6
Total zone transitions, hab. session 10.30.51.4-1.2-1.1-0.70.90.7-0.60.80.7-0.30.10.1-0.7-0.5-0.4
Total locomotion distance, hab. session 10.40.61.8-1.3-1.2-0.70.90.6-0.40.80.7-0.1-0.20.4-1.0-0.80.2
Locomotion velocity, hab. session 10.60.92.5-1.6-1.5-1.01.21.0-0.81.21.0-0.50.2-0.0-0.7-0.5-0.6
Time in familiar zone, hab. session 27.27.68.6-2.5-2.6-2.82.72.8-2.92.82.8-2.92.9-2.92.82.9-2.3
Time in novel zone, hab. session 25.85.96.62.12.22.4-2.4-2.42.6-2.4-2.42.5-2.62.6-2.4-2.52.4
Total zone transitions, hab. session 21.31.75.80.30.30.9-0.7-0.91.2-0.8-0.91.4-1.61.7-2.4-2.30.4
Total locomotion distance, hab. session 20.40.61.4-1.2-1.2-0.70.90.7-0.50.90.7-0.30.10.0-0.7-0.5-0.9
Locomotion velocity, hab. session 20.40.61.4-1.2-1.2-0.60.90.6-0.30.80.6-0.2-0.10.3-1.1-0.9-0.9
Novel to familiar place preference ratio5.35.86.92.02.12.4-2.3-2.32.4-2.5-2.42.5-2.62.6-2.6-2.62.4
Novelty place preference3.43.74.81.51.61.9-1.8-1.81.8-1.9-1.92.0-2.12.1-2.1-2.22.0
Time in novel zone, NPP test3.84.04.81.61.82.0-1.9-1.92.0-2.1-2.02.1-2.22.2-2.1-2.22.1
Total zone transitions, NPP test0.40.62.60.0-0.00.4-0.2-0.40.6-0.2-0.40.7-0.80.9-1.6-1.5-0.6
Total locomotion distance, NPP test0.40.62.50.00.00.5-0.3-0.50.7-0.3-0.50.8-0.91.0-1.6-1.40.0
Locomotion velocity, NPP test0.30.41.8-0.3-0.30.20.0-0.20.4-0.0-0.20.5-0.70.8-1.3-1.2-0.3
Intraocular pressure0.50.72.10.20.0-0.40.20.4-0.50.40.4-0.81.0-1.11.51.3-1.4
Delta distance traveled before/after self-admin0.40.50.8-0.5-0.6-0.60.60.6-0.50.70.9-0.70.7-0.70.80.9-0.7
Delta ambulatory time before/after self-admin0.20.30.7-0.5-0.6-0.50.60.5-0.40.60.8-0.50.5-0.50.40.6-0.5
Parametrial fat weight0.00.00.2-0.0-0.00.1-0.0-0.00.2-0.2-0.10.2-0.30.3-0.4-0.4-0.1
Pavlov. Cond. lever latency0.30.41.40.00.0-0.30.20.3-0.50.20.3-0.60.8-0.91.21.1-0.3
Pavlov. Cond. magazine entry latency2.63.44.1-1.9-2.0-2.02.01.9-1.72.02.0-1.81.8-1.71.31.5-1.9
Pavlov. Cond. change in total contacts0.00.00.1-0.2-0.2-0.20.20.2-0.00.20.2-0.10.1-0.1-0.1-0.0-0.4
Pavlov. Cond. index score0.20.20.5-0.7-0.7-0.50.60.5-0.30.60.5-0.30.2-0.1-0.1-0.1-0.5
Pavlov. Cond. latency score0.10.20.5-0.6-0.7-0.40.50.4-0.20.50.4-0.1-0.00.1-0.4-0.3-0.3
Pavlov. Cond. lever contacts0.30.31.20.00.00.3-0.2-0.30.5-0.2-0.30.6-0.70.8-1.1-1.00.3
Pavlov. Cond. magazine entry number0.70.91.20.91.01.0-1.0-0.90.8-1.0-1.00.9-0.90.9-0.7-0.81.1
Pavlov. Cond. intertrial magazine entries0.40.51.0-0.3-0.4-0.60.50.6-0.50.60.6-0.80.8-0.91.01.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.30.7-0.8-0.8-0.60.70.6-0.50.70.6-0.50.4-0.30.00.1-0.6
Pavlov. Cond. response bias0.70.81.2-0.9-1.0-1.01.00.9-0.81.01.0-0.90.8-0.80.60.7-1.1
Pavlov. Cond. lever latency0.81.11.71.11.01.1-1.1-1.11.1-1.1-1.11.0-1.00.9-1.3-1.2-0.2
Pavlov. Cond. magazine entry latency0.40.40.6-0.8-0.7-0.70.70.7-0.70.70.7-0.60.6-0.60.70.70.2
Pavlov. Cond. change in total contacts0.71.11.6-1.0-0.9-1.01.01.1-1.11.01.0-1.11.1-1.11.31.2-0.3
Pavlov. Cond. index score0.71.01.5-1.0-0.9-1.01.01.0-1.11.01.0-1.01.0-0.91.21.20.2
Pavlov. Cond. latency score0.70.91.2-1.1-0.9-1.01.01.0-1.01.01.0-0.90.9-0.81.01.00.2
Pavlov. Cond. lever contacts0.71.02.0-0.9-0.8-1.00.91.0-1.01.01.0-1.01.0-1.01.41.30.2
Pavlov. Cond. magazine entry number0.60.71.11.00.90.9-0.9-0.91.0-0.9-0.90.8-0.80.7-0.8-0.9-0.3
Pavlov. Cond. intertrial magazine entries0.10.20.50.70.60.5-0.6-0.50.4-0.5-0.50.3-0.20.10.40.10.3
Pavlov. Cond. lever-magazine prob. diff.0.70.91.2-1.1-0.9-1.01.01.0-1.01.01.0-0.90.9-0.81.11.10.2
Pavlov. Cond. response bias1.92.63.9-1.6-1.5-1.61.61.6-1.71.61.6-1.61.6-1.62.01.9-0.3
Time in closed arm before self-admin0.81.01.70.70.70.9-0.8-1.01.1-0.9-0.91.1-1.21.3-1.3-1.20.8
Time in closed arm after self-admin0.40.41.4-0.3-0.3-0.50.40.4-0.40.50.5-0.60.7-0.71.21.1-0.7
Time in open arm before self-admin0.20.20.4-0.6-0.5-0.50.50.6-0.60.30.6-0.40.4-0.30.10.1-0.1
Time in open arm after self-admin0.80.91.21.01.01.1-1.0-0.90.9-1.1-1.00.9-0.90.8-1.1-1.10.8
Bone: periosteal estimation0.51.12.40.50.70.9-0.8-0.91.1-0.9-0.91.2-1.21.3-1.2-1.21.5
Bone: periosteal perimeter0.10.10.7-0.5-0.3-0.10.20.10.10.10.10.2-0.30.4-0.5-0.40.8
Bone: post-yield work0.50.81.11.01.01.0-1.0-0.91.0-0.9-1.00.9-0.80.8-0.5-0.60.8
Progressive ratio test 1 active lever presses0.30.30.7-0.1-0.2-0.50.30.4-0.50.40.4-0.70.8-0.90.80.8-0.3
Progressive ratio test 1 breakpoint0.20.30.7-0.0-0.1-0.50.30.4-0.50.40.3-0.60.8-0.80.80.8-0.3
Progressive ratio test 1 inactive lever presses0.30.50.7-0.5-0.5-0.70.60.6-0.70.60.6-0.80.8-0.80.80.8-0.6
Progressive ratio test 2 active lever presses0.70.91.7-0.5-0.5-0.90.71.0-1.10.60.7-1.11.2-1.31.11.1-0.7
Progressive ratio test 2 breakpoint0.81.01.8-0.5-0.6-1.00.81.0-1.10.70.8-1.21.3-1.41.21.1-0.7
Progressive ratio test 2 inactive lever presses0.10.20.4-0.4-0.4-0.60.50.6-0.60.30.4-0.50.5-0.50.10.2-0.4
Incentive Sensitization - Responses0.20.20.70.10.0-0.40.10.4-0.50.00.2-0.60.7-0.80.50.5-0.8
Incentive Sensitization - Breakpoint0.20.30.7-0.1-0.1-0.50.20.5-0.60.10.3-0.60.7-0.80.50.5-0.8
Sum of active levers in priming session hrs 5-60.00.00.40.00.1-0.0-0.1-0.0-0.2-0.1-0.00.0-0.00.00.60.20.1
Progressive ratio0.20.31.70.80.60.5-0.6-0.40.4-0.4-0.50.3-0.20.1-0.6-0.5-1.3
Food seeking constrained by brief footshock0.20.21.6-0.3-0.4-0.30.40.3-0.30.30.3-0.30.2-0.2-0.2-0.1-1.3
Seeking ratio, punishment vs. effort0.10.20.5-0.7-0.6-0.40.50.4-0.30.40.4-0.20.2-0.10.30.30.2
Retroperitoneal fat weight0.20.92.31.51.41.2-1.3-1.11.1-1.1-1.20.7-0.60.4-0.1-0.3-0.3
Reaction time number correct0.10.30.91.00.90.4-0.6-0.50.3-0.4-0.40.10.1-0.30.70.60.3
Reaction time mean minus median0.30.81.2-1.0-0.9-1.00.91.1-1.10.90.9-0.90.9-0.90.90.9-0.1
Reaction time mean minus median AUC0.10.31.5-0.10.00.2-0.1-0.10.2-0.2-0.30.5-0.50.7-0.8-0.71.2
Reaction time num false alarms0.10.10.80.40.40.2-0.3-0.0-0.0-0.2-0.2-0.10.2-0.30.50.40.9
Reaction time num false alarms AUC0.10.10.50.40.50.2-0.30.0-0.0-0.2-0.2-0.20.3-0.40.60.50.7
Reaction time trials correct on left0.10.30.91.00.90.4-0.6-0.50.3-0.4-0.40.10.1-0.30.70.60.3
Reaction time trials on left0.10.30.91.00.90.4-0.6-0.50.3-0.5-0.50.10.1-0.20.60.50.4
Reaction time mean0.10.20.80.00.20.3-0.2-0.20.3-0.3-0.30.4-0.50.6-0.7-0.50.9
Reaction time mean AUC0.20.20.90.10.20.4-0.3-0.30.4-0.3-0.30.5-0.50.6-0.7-0.61.0
Median of all reaction times0.50.71.20.50.60.8-0.7-0.70.8-0.8-0.70.9-1.01.0-1.1-1.01.1
Reaction time omissions0.10.10.3-0.6-0.5-0.30.30.4-0.20.20.2-0.1-0.00.1-0.2-0.3-0.0
Reaction time false alarm rate0.00.10.60.10.20.2-0.2-0.00.1-0.2-0.20.1-0.10.1-0.1-0.10.8
Reaction time premature initiation rate1.21.72.0-1.1-1.2-1.31.31.4-1.31.31.3-1.41.4-1.41.31.4-1.1
Reaction time premature initiations1.01.83.3-0.7-0.8-1.31.01.2-1.21.21.2-1.51.6-1.71.81.8-1.0
Std. dev. reaction times0.10.10.3-0.6-0.4-0.40.40.5-0.50.40.4-0.30.3-0.20.10.20.3
Reaction time trials completed0.10.30.91.00.90.4-0.6-0.50.3-0.5-0.50.10.1-0.20.60.50.4
Reaction time trials AUC0.10.30.90.90.80.3-0.6-0.40.2-0.4-0.4-0.00.2-0.40.80.70.3
Run reversals in cocaine runway, females0.30.30.6-0.7-0.8-0.60.70.7-0.60.60.5-0.40.3-0.20.20.10.0
Run reversals in cocaine runway, males1.01.01.7-1.2-1.3-1.11.21.1-0.91.21.1-0.90.8-0.70.90.9-0.5
Latency to leave start box in cocaine runway0.20.30.9-0.9-0.8-0.60.70.6-0.50.40.4-0.20.10.1-0.2-0.30.3
Latency to leave start box in cocaine runway, F0.50.61.8-0.1-0.10.2-0.2-0.20.5-0.5-0.50.7-0.91.1-1.2-1.31.2
Latency to leave start box in cocaine runway, M2.42.22.5-1.4-1.4-1.51.41.5-1.61.51.5-1.51.5-1.51.51.5-1.3
Std. dev. time between licks in bursts0.40.61.2-1.1-1.0-0.80.90.8-0.80.80.8-0.60.5-0.40.20.30.5
Total sessions with >9 infusions0.50.61.1-0.5-0.5-0.90.70.8-0.80.50.6-0.80.9-0.91.00.9-0.3
Short access day 1 total inactive lever presses0.40.51.3-0.6-0.6-0.80.70.7-0.70.60.7-0.70.7-0.80.30.4-1.1
Short access day 10 total inactive lever presses0.10.20.6-0.1-0.1-0.30.20.4-0.40.20.2-0.50.6-0.60.70.6-0.7
Short access day 1 total infusions0.30.30.6-0.6-0.6-0.70.60.6-0.60.50.6-0.60.6-0.60.40.5-0.5
Short access day 10 total infusions0.20.20.5-0.1-0.2-0.50.30.4-0.50.30.2-0.60.6-0.70.70.6-0.3
Short access total infusions0.40.50.8-0.6-0.6-0.90.70.8-0.80.60.6-0.80.8-0.90.70.7-0.5
Short access day 1 locomotion1.51.92.3-1.4-1.3-1.51.41.4-1.51.21.4-1.41.4-1.41.51.4-0.7
Short access day 10 total locomotion5.39.711.3-2.9-2.9-3.33.03.2-3.32.93.0-3.33.4-3.33.13.1-2.7
Short access total locomotion2.93.54.5-1.8-1.7-2.11.92.0-2.01.71.8-2.02.0-2.02.12.0-1.3
One hour access (0.3 mA shock)0.00.00.00.10.1-0.1-0.00.0-0.1-0.1-0.1-0.10.1-0.2-0.1-0.10.1
Compulsive drug intake1.72.03.10.91.01.3-1.2-1.31.4-1.4-1.41.6-1.61.7-1.6-1.71.3
One hour access (shock baseline)0.60.91.5-0.6-0.7-1.00.80.9-1.00.90.9-1.11.2-1.21.01.1-0.6
Social response proportion0.50.61.5-1.1-1.0-0.70.90.6-0.60.90.8-0.60.5-0.4-0.2-0.0-1.2
Social responses5.36.911.2-3.4-3.1-2.93.02.8-2.82.92.9-2.52.3-2.11.71.8-1.7
Social time0.30.50.70.80.70.8-0.8-0.80.7-0.7-0.70.7-0.60.6-0.5-0.6-0.4
Soleus weight7.522.027.35.25.25.0-5.1-5.15.0-5.1-5.04.7-4.54.3-3.4-3.63.9
Bone: stiffness3.04.95.82.02.22.3-2.2-2.22.4-2.3-2.32.3-2.22.2-1.9-2.02.2
Tibialis anterior weight0.93.03.92.02.02.0-1.9-1.71.7-1.9-2.01.7-1.71.6-0.9-1.31.6
Time to tail flick, vehicle, before self-admin0.10.10.4-0.3-0.3-0.20.20.2-0.20.20.1-0.1-0.00.10.60.20.2
Time to tail flick, vehicle, after self-admin0.71.02.0-0.4-0.5-0.70.60.7-0.80.90.6-1.11.2-1.31.41.4-1.2
Time to tail flick, test, before self-admin0.10.10.3-0.6-0.5-0.40.40.3-0.20.30.5-0.10.00.0-0.3-0.00.3
Time to tail flick, test, after self-admin0.10.10.1-0.2-0.2-0.20.20.2-0.00.30.2-0.20.2-0.20.30.4-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.40.60.50.2-0.3-0.20.1-0.0-0.3-0.20.4-0.50.40.5-0.7
Delta time to tail flick, test, before/after SA0.20.20.80.10.1-0.10.10.2-0.20.30.2-0.40.5-0.60.90.8-0.7
Tibia length0.82.32.8-1.6-1.6-1.61.61.6-1.61.71.6-1.61.6-1.51.21.3-1.2
Ambulatory time before self-admin0.10.20.50.20.30.3-0.3-0.20.2-0.5-0.60.4-0.40.4-0.2-0.50.7
Ambulatory time after self-admin0.00.00.0-0.1-0.10.00.00.1-0.0-0.10.00.0-0.10.10.1-0.10.2
Bone: tissue strength2.02.02.41.41.41.5-1.5-1.51.6-1.5-1.51.5-1.51.4-1.4-1.50.8
Total heroin consumption1.31.52.2-1.5-1.4-1.31.31.3-1.51.31.2-1.11.0-1.01.21.0-0.8
Bone: trabecular number0.10.20.7-0.8-0.7-0.40.60.4-0.40.50.4-0.1-0.10.2-0.4-0.30.4
Bone: trabecular spacing0.30.41.50.80.70.1-0.4-0.1-0.0-0.1-0.1-0.40.6-0.81.21.1-0.7
Bone: trabecular thickness1.41.85.5-0.20.10.7-0.4-0.71.0-0.7-0.71.4-1.71.9-2.4-2.21.7
Bone: trabecular tissue density0.91.32.31.51.41.3-1.4-1.31.4-1.3-1.31.1-1.00.8-0.8-0.90.1
Water consumed over 24 hours0.81.11.80.91.01.1-1.0-1.11.1-1.1-1.11.1-1.21.2-0.7-0.91.4
Number of responses in last shaping day2.12.33.2-1.3-1.3-1.71.51.5-1.61.41.4-1.61.6-1.61.81.7-0.8