Hub : Genes

Sf3a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Sf3a1 0.06 0.03 2.9e-07 0.07 0.06 0.07 0.07 3.4e-08 5.6e-07 1.6e-08 4.6e-08
2 BLA mRNA stability Sf3a1 0.1 0.06 1.4e-03 0 0.01 0.01 0.02 1.9e-01 5.6e-02 7.1e-02 2.7e-02
3 Liver gene expression Sf3a1 0.04 0.03 5.7e-04 0.02 0.02 0.02 0.02 1.1e-03 2.0e-03 5.3e-03 9.8e-04
4 Liver mRNA stability Sf3a1 0.06 0.04 2.0e-05 0.05 0.04 0.03 0.04 5.3e-06 2.6e-05 1.3e-04 1.1e-05
5 Brain gene expression Sf3a1 0.39 0.1 0.0e+00 0.29 0.29 0.29 0.29 3.3e-27 9.2e-27 4.0e-27 3.4e-27
6 BLA gene expression Sf3a1 0.36 0.13 2.4e-15 0.26 0.25 0.26 0.27 5.5e-14 1.1e-13 2.0e-14 1.1e-14
7 IL gene expression Sf3a1 0.4 0.14 2.2e-06 0.24 0.15 0.1 0.21 1.8e-06 1.8e-04 2.5e-03 1.0e-05
8 PL gene expression Sf3a1 0.5 0.12 0.0e+00 0.43 0.4 0.43 0.43 3.0e-51 2.5e-46 4.9e-51 2.1e-51
9 NAcc gene expression Sf3a1 0.35 0.1 0.0e+00 0.29 0.28 0.28 0.29 1.5e-33 4.8e-32 7.9e-33 6.2e-34
10 pVTA gene expression Sf3a1 0.19 0.08 2.1e-06 0.16 0.14 0.15 0.16 3.2e-07 1.5e-06 5.8e-07 2.2e-07
11 RMTg gene expression Sf3a1 0.25 0.12 4.7e-04 0.1 0.07 0.07 0.08 1.4e-03 5.3e-03 5.3e-03 3.2e-03
12 Adipose mRNA stability Sf3a1 0.1 0.05 4.2e-09 0.05 0.06 0.05 0.06 1.4e-06 3.6e-07 1.5e-06 1.8e-07
13 OFC gene expression Sf3a1 0.5 0.12 1.2e-09 0.25 0.29 0.22 0.27 1.2e-06 1.3e-07 6.3e-06 3.6e-07
14 LHb gene expression Sf3a1 0.31 0.18 2.5e-03 0.07 0.06 0.04 0.07 1.1e-02 2.0e-02 3.2e-02 1.2e-02
15 Brain mRNA stability Sf3a1 0.05 0.03 4.8e-04 0.03 0.04 0.04 0.04 1.6e-03 7.0e-05 6.5e-05 2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.02.7-0.91.60.8-1.0-0.91.1-1.01.11.01.2-1.20.61.2-0.4-0.4
Area under the delay curve9.39.811.73.0-3.2-3.23.43.3-3.33.3-3.3-3.2-3.13.2-2.9-3.02.63.0
BMI with tail0.31.13.51.9-1.7-0.80.80.9-1.00.8-0.9-0.7-0.80.9-0.3-1.6-0.10.5
BMI without tail0.20.32.21.5-1.0-0.40.30.2-0.40.2-0.3-0.2-0.00.40.1-0.6-0.2-0.5
Body weight1.56.312.23.5-3.2-2.62.42.4-2.62.3-2.5-2.3-2.22.5-2.0-3.01.81.7
Weight adjusted by age1.11.24.21.9-2.1-1.11.00.9-1.10.7-1.1-1.0-0.51.1-0.7-1.00.60.4
Bone surface0.10.20.40.30.1-0.50.40.4-0.40.4-0.3-0.3-0.30.3-0.6-0.20.60.7
Bone volume0.00.10.30.00.5-0.30.20.2-0.00.1-0.0-0.2-0.0-0.0-0.40.10.50.4
Breakpoint value in progressive ratio session0.40.40.70.4-0.2-0.70.70.7-0.50.8-0.6-0.7-0.80.6-0.6-0.60.90.8
Number of licking bursts1.92.23.61.8-1.9-1.71.51.4-1.61.5-1.5-1.2-1.31.7-1.5-1.41.50.7
Context. condit. distance diff. score3.13.85.4-1.51.72.1-2.0-2.02.0-1.92.02.01.9-2.02.21.6-2.3-1.7
Locomotion velocity, session 10.10.21.6-1.30.40.5-0.1-0.10.0-0.20.30.1-0.2-0.0-0.10.10.30.2
Locomotion distance, session 12.43.13.9-1.42.01.9-1.9-1.91.8-1.91.91.81.9-1.91.51.8-1.3-1.2
Locomotion velocity, session 20.40.43.9-2.01.20.40.10.00.30.10.1-0.2-0.30.0-0.30.40.60.7
Locomotion distance, session 22.23.07.1-2.72.41.9-1.6-1.61.8-1.61.81.61.4-1.71.31.9-1.1-0.9
Locomotion velocity, session 31.72.02.5-1.21.61.5-1.5-1.51.4-1.51.41.51.5-1.41.51.4-1.6-0.7
Locomotion distance, session 30.30.40.70.0-0.3-0.50.60.6-0.70.6-0.7-0.6-0.60.8-0.7-0.30.70.8
Stereotopy head waving bouts, day 31.82.13.0-1.41.31.7-1.6-1.71.4-1.61.51.61.5-1.51.21.4-0.7-1.3
Stereotopy head waving duration, day 33.23.95.1-1.81.62.2-2.1-2.31.9-2.22.12.12.0-2.01.91.7-1.6-1.9
Locomotion velocity, session 70.10.10.9-0.3-0.30.10.0-0.0-0.20.0-0.1-0.1-0.10.1-0.60.00.90.3
Locomotion distance, session 70.91.12.2-1.50.91.3-1.2-1.21.0-1.11.21.21.0-1.20.71.1-0.5-0.5
Stereotopy head waving bouts, day 70.00.00.40.1-0.2-0.00.00.0-0.1-0.00.00.0-0.00.10.3-0.0-0.60.1
Stereotopy head waving duration, day 70.10.20.70.8-0.8-0.40.30.3-0.40.3-0.2-0.2-0.20.3-0.1-0.3-0.20.1
Locomotion velocity, session 81.31.64.9-2.21.71.5-1.2-1.11.4-1.01.21.10.9-1.11.01.1-0.8-0.9
Locomotion distance, session 88.812.915.7-3.53.64.0-3.7-3.73.8-3.63.73.63.5-3.63.63.4-3.3-3.1
Degree of sensitization distance5.25.26.5-2.31.82.5-2.4-2.52.4-2.42.42.42.2-2.42.22.0-1.8-2.2
Degree of sensitization stereotypy0.60.61.31.1-1.1-0.90.80.9-0.80.8-0.7-0.7-0.70.8-0.4-0.70.10.5
Conditioned locomotion0.50.61.3-0.11.20.6-0.7-0.70.8-0.80.90.80.8-1.00.80.9-0.9-0.3
Cocaine response after cond. corrected0.60.71.20.9-0.8-1.00.80.8-0.90.7-0.8-0.8-0.70.9-0.9-0.70.81.1
Cocaine response after cond. not corrected1.11.22.51.6-0.8-1.21.11.1-1.11.1-1.0-0.9-0.91.0-1.2-1.21.11.3
Cocaine response before conditioning0.10.10.30.50.50.3-0.2-0.20.30.00.40.40.2-0.40.2-0.3-0.2-0.1
Saline control response1.31.73.4-1.81.51.5-1.3-1.31.2-1.51.31.21.1-1.21.11.2-1.0-0.7
Bone: connectivity density0.61.01.6-0.61.30.9-1.1-1.01.0-1.01.11.11.2-1.20.81.1-0.8-0.5
Bone: cortical apparent density0.10.10.20.4-0.4-0.40.30.2-0.20.2-0.4-0.3-0.20.4-0.2-0.20.2-0.0
Bone: cortical area2.74.19.23.0-2.7-2.01.81.9-2.01.8-1.9-1.8-1.71.9-1.9-2.51.61.1
Bone: cortical porosity0.10.20.50.6-0.1-0.50.20.4-0.30.6-0.2-0.2-0.20.1-0.5-0.10.40.7
Bone: cortical porosity0.00.00.10.30.1-0.2-0.10.10.00.30.10.10.0-0.2-0.10.1-0.10.3
Bone: cortical thickness1.72.88.93.0-2.5-1.71.41.5-1.71.4-1.5-1.4-1.21.5-1.4-1.91.10.8
Bone: cortical thickness0.50.51.10.40.30.6-0.9-0.80.6-0.80.70.81.0-0.70.70.7-0.7-0.9
Bone: cortical tissue density0.10.10.30.4-0.4-0.50.40.3-0.30.3-0.5-0.4-0.30.4-0.2-0.30.30.1
Condit. Reinf. active minus inactive responses0.10.10.6-0.8-0.10.30.0-0.0-0.4-0.2-0.1-0.1-0.10.3-0.3-0.20.50.4
Condit. Reinf. active-inactive response ratio0.20.23.0-1.70.20.5-0.1-0.1-0.1-0.30.20.1-0.20.10.10.2-0.10.1
Condit. Reinf. active responses0.10.10.4-0.70.10.6-0.4-0.4-0.0-0.60.20.20.40.0-0.00.10.2-0.2
Condit. Reinf. inactive responses0.10.11.21.1-0.20.1-0.1-0.20.1-0.1-0.00.00.3-0.0-0.1-0.30.4-0.5
Incentive salience index mean0.40.40.90.1-0.5-0.40.60.6-0.80.3-0.7-0.7-0.60.8-0.8-0.81.00.7
Condit. Reinf. lever presses0.30.40.90.9-0.4-0.50.60.7-0.70.3-0.7-0.7-0.50.6-0.8-0.90.80.4
Condit. Reinf. active minus inactive responses0.70.81.3-0.70.51.1-1.2-1.20.7-1.10.81.11.2-0.50.90.9-0.6-1.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.2-0.10.1-0.2-0.2-0.2-0.2-0.2-0.10.10.4-0.00.20.10.2
Condit. Reinf. active responses1.92.73.9-1.91.32.0-1.9-1.91.3-1.81.61.81.8-1.21.61.6-1.2-1.3
Condit. Reinf. inactive responses2.63.34.4-2.01.62.1-1.9-1.91.7-1.91.81.91.8-1.61.81.6-1.6-1.6
Condit. Reinf. lever presses0.70.91.3-0.80.61.1-1.1-1.20.8-1.01.01.11.1-0.81.00.9-0.9-0.7
Condit. Reinf. lever reinforcers received1.82.53.6-1.71.11.9-1.9-1.91.2-1.81.61.81.8-1.21.51.5-1.2-1.1
Conditioned reinforcement - actives1.31.32.21.4-1.1-1.01.11.2-1.21.2-1.3-1.2-1.21.1-0.8-1.50.31.3
Conditioned reinforcement - inactives2.42.73.71.5-1.8-1.71.71.7-1.81.6-1.8-1.7-1.61.8-1.4-1.61.01.9
Conditioned locomotion0.50.51.61.3-0.8-0.70.50.6-0.60.7-0.8-0.7-0.70.6-0.6-0.90.40.7
Patch foraging indifference point 0 sec0.30.41.00.6-0.9-0.80.70.5-0.60.4-0.7-0.7-0.50.8-0.7-0.41.00.0
Patch foraging indifference point AUC0.50.62.6-1.60.90.8-0.6-0.50.8-0.50.80.60.4-0.9-0.00.80.6-0.3
Delay disc. indifference point, 0s delay5.15.68.42.7-2.5-2.52.52.4-2.52.5-2.4-2.5-2.32.2-1.9-2.31.12.9
Delay disc. indifference point, 16s delay6.86.88.61.7-2.4-2.62.92.7-2.72.7-2.9-2.8-2.72.8-2.4-2.62.32.7
Delay disc. indifference point, 2s delay4.85.48.12.8-2.7-2.52.42.4-2.52.3-2.4-2.3-1.92.3-2.0-1.91.42.4
Delay disc. indifference point, 24s delay4.24.06.41.6-1.6-2.02.22.1-2.22.1-2.1-2.1-2.02.1-1.8-2.11.32.5
Delay disc. indifference point, 4s delay4.44.66.22.4-2.1-2.22.22.1-2.32.3-2.1-2.0-2.12.0-2.1-1.91.82.5
Delay disc. indifference point, 8s delay2.62.63.21.3-1.8-1.61.71.7-1.71.8-1.7-1.6-1.71.8-1.6-1.41.71.1
Indifference point function ln k0.10.20.30.40.50.3-0.5-0.60.2-0.50.40.50.6-0.40.30.1-0.3-0.1
Indifference point function log k0.10.20.30.40.50.3-0.5-0.60.2-0.50.40.50.6-0.40.30.1-0.3-0.1
Patch foraging total patch changes 0 sec0.40.61.40.6-0.9-0.90.80.7-0.70.6-0.8-0.8-0.70.9-0.9-0.61.20.2
Patch foraging total patch changes 12 sec0.10.10.60.4-0.3-0.30.30.3-0.10.3-0.2-0.3-0.30.1-0.5-0.50.8-0.1
Patch foraging total patch changes 18 sec0.81.01.7-0.1-0.9-1.00.91.1-0.71.2-0.9-1.2-1.30.8-1.1-0.91.30.7
Patch foraging total patch changes 24 sec1.92.33.5-1.91.01.7-1.6-1.61.5-1.61.41.31.4-1.31.71.4-1.6-1.7
Patch foraging total patch changes 6 sec0.20.21.0-0.1-0.5-0.40.40.3-0.50.3-0.4-0.4-0.50.5-0.6-0.31.00.2
Patch foraging time to switch 0 sec0.30.52.01.2-1.1-0.40.30.2-0.20.3-0.5-0.3-0.20.50.8-0.4-1.4-0.7
Patch foraging water rate 0 sec0.40.63.80.5-0.6-0.40.60.6-0.50.5-0.4-0.5-0.60.3-1.3-0.91.90.3
Patch foraging water rate 12 sec0.20.30.7-0.30.40.7-0.7-0.50.5-0.50.80.70.6-0.8-0.00.30.4-0.4
Patch foraging water rate 18 sec1.62.13.60.30.81.4-1.7-1.71.4-1.71.51.71.9-1.61.21.2-0.8-1.9
Patch foraging water rate 24 sec0.20.31.10.0-0.10.6-0.6-0.40.5-0.30.70.70.3-0.80.1-0.30.2-1.0
Patch foraging water rate 6 sec0.20.20.50.3-0.20.4-0.4-0.40.4-0.40.70.70.4-0.7-0.20.00.6-0.7
Seeking ratio, delayed vs. immediate footshock0.20.20.8-0.90.80.1-0.4-0.10.3-0.10.20.20.1-0.1-0.30.70.30.6
Distance traveled before self-admin0.20.20.7-0.80.5-0.40.40.2-0.00.1-0.3-0.50.00.3-0.30.90.70.3
Distance traveled after self-admin0.40.40.80.1-0.1-0.70.80.6-0.60.7-0.8-0.9-0.40.8-0.60.20.70.7
Extensor digitorum longus weight2.610.415.53.9-3.9-3.32.83.0-3.42.8-3.1-2.9-2.73.2-3.5-3.33.72.3
Bone: elastic displacement0.50.61.10.00.30.6-0.9-0.80.7-0.70.70.91.0-0.70.90.7-0.9-1.1
Bone: elastic work0.30.32.21.5-0.6-0.0-0.3-0.10.3-0.20.30.40.5-0.50.2-0.2-0.2-1.1
Bone: endosteal estimation0.00.00.10.1-0.3-0.30.20.3-0.10.1-0.1-0.2-0.30.1-0.3-0.20.40.0
Bone: endosteal perimeter0.71.41.51.1-1.2-1.21.11.2-1.21.2-1.2-1.2-1.21.2-1.2-1.21.11.1
Epididymis fat weight0.10.31.31.1-0.4-0.70.40.5-0.20.5-0.3-0.3-0.30.30.3-0.4-0.8-0.2
Delta time in closed arm before/after self-admin5.35.16.2-1.92.52.4-2.4-2.42.3-2.32.32.42.4-2.32.42.1-2.3-1.5
Delta time in open arm before/after self-admin7.27.09.31.9-3.0-2.82.82.8-2.62.9-2.6-2.8-2.82.5-2.7-2.42.62.1
Diff in mean of infusions in LGA sessions0.20.20.5-0.1-0.2-0.60.50.5-0.30.6-0.3-0.5-0.30.50.10.1-0.40.7
Delay discount exponential model param8.59.010.6-2.93.13.1-3.3-3.23.1-3.13.13.03.0-3.02.82.8-2.5-2.9
Extinction: sum of active levers before priming1.51.54.00.1-0.8-1.11.21.2-1.31.2-1.2-1.3-1.31.4-1.1-1.01.02.0
Active lever presses in extinction session 60.80.83.10.9-0.2-0.90.80.9-0.81.1-0.8-0.8-0.90.6-0.8-0.70.51.8
Bone: final force0.20.42.11.0-1.4-0.50.30.5-0.40.4-0.3-0.3-0.40.3-0.4-0.70.3-0.4
Bone: final moment0.30.52.31.1-1.5-0.70.40.6-0.50.6-0.5-0.5-0.50.3-0.5-0.70.5-0.2
Food consumed during 24 hour testing period0.40.52.0-0.1-0.9-0.40.60.6-0.70.5-0.6-0.6-0.80.7-1.0-0.71.40.2
Glucose15.823.732.71.7-3.9-4.55.35.2-4.95.4-4.7-5.2-5.74.7-5.3-4.95.34.9
Heart weight0.30.40.7-0.40.50.8-0.6-0.50.5-0.70.70.70.5-0.50.80.2-0.8-0.7
Delay discount hyperbolic model param8.69.110.7-3.03.23.1-3.3-3.13.2-3.13.13.03.0-3.02.82.9-2.4-2.9
Intermittent access intake day 1-15 change1.01.01.60.4-0.8-0.81.21.0-1.01.0-1.1-1.2-1.21.1-0.9-1.30.61.2
Intermittent access intake escalation0.60.61.10.3-0.6-0.61.00.8-0.70.8-0.9-0.9-1.00.9-0.6-1.00.31.0
Intermittent access intake escalation 20.10.10.30.0-0.4-0.20.50.3-0.20.3-0.3-0.5-0.50.4-0.4-0.40.5-0.0
Intermitt. access day 1 inactive lever presses0.90.91.8-0.80.81.1-1.0-1.00.9-1.20.80.91.2-0.91.20.7-1.3-0.4
Intermitt. access day 15 inactive lever presses0.60.72.00.6-1.4-0.50.80.6-1.00.6-0.8-0.7-0.71.0-0.8-1.20.70.5
Intermitt. access escalation Index0.20.10.4-0.50.20.4-0.4-0.40.3-0.40.30.30.3-0.40.40.2-0.2-0.6
Intermittent access day 1 total infusions0.60.71.21.0-0.8-1.11.01.1-0.61.0-0.9-0.9-0.90.8-0.7-0.60.20.6
Intermittent access day 15 total infusions2.02.33.01.2-1.6-1.61.71.7-1.51.6-1.6-1.6-1.71.6-1.3-1.50.81.4
Intermittent access terminal intake (last 3 days)0.80.91.30.8-0.9-1.01.11.1-0.81.1-1.0-1.0-1.11.0-0.8-1.00.40.8
Intermittent access total infusions0.91.01.40.9-0.9-1.11.11.1-1.01.2-1.1-1.0-1.11.1-1.0-0.90.61.0
Intermittent access day 1 locomotion0.70.81.4-1.01.10.7-0.8-0.71.1-0.70.80.70.7-0.90.81.2-0.9-0.7
Intermittent access day 15 total locomotion2.62.84.01.9-1.8-1.71.81.7-1.51.9-1.8-1.7-1.91.7-1.3-2.00.81.4
Intermittent access total locomotion0.81.01.60.6-0.8-1.01.01.1-0.81.3-1.0-1.0-1.30.9-0.9-0.80.61.2
Intermittent access standard deviation0.40.51.0-0.30.30.8-0.6-0.70.7-0.70.50.60.7-0.50.80.6-1.0-0.8
Left kidney weight0.51.42.6-0.10.41.0-1.3-1.21.1-1.31.11.01.4-1.21.40.8-1.5-1.6
Right kidney weight0.92.45.70.01.01.2-1.5-1.61.5-1.71.41.41.9-1.52.11.4-2.4-1.6
Cocaine induced anxiety1.11.23.60.4-0.5-1.01.11.1-1.01.1-0.9-1.0-1.20.9-1.6-1.01.91.1
Post-drug Anxiety0.60.71.30.4-0.2-0.80.80.9-0.70.9-0.6-0.8-1.10.5-1.1-0.91.11.1
Baseline Anxiety0.70.71.10.9-0.9-0.80.90.9-0.90.9-1.0-0.9-0.91.0-0.4-1.1-0.10.7
Tail length0.41.13.21.8-1.1-1.30.90.8-1.00.8-0.9-0.9-0.50.9-1.1-0.61.60.2
Length with tail0.93.46.72.6-2.1-2.11.81.8-1.81.7-1.7-1.7-1.61.7-1.8-1.92.00.9
Length without tail1.32.94.31.7-1.8-1.71.61.8-1.71.7-1.7-1.6-1.91.7-1.6-2.11.51.3
Times rat made contact with spout0.40.51.9-1.40.0-0.30.60.6-0.50.6-0.6-0.7-0.90.8-0.6-0.20.80.6
Lifetime Intake0.80.91.20.9-0.9-1.01.01.0-0.91.0-1.1-1.0-0.91.0-0.9-0.80.61.0
Liver weight, left4.67.39.5-1.92.52.4-2.7-2.82.8-2.92.72.83.0-2.72.83.1-2.8-2.3
Liver weight, right5.28.710.7-1.41.92.9-3.1-3.13.0-3.13.13.23.3-3.23.12.9-3.3-2.9
Locomotor activity0.71.13.4-0.10.0-0.91.31.1-0.81.2-0.9-1.0-1.20.8-1.5-0.71.80.9
Locomotor testing distance0.20.41.61.1-0.1-0.50.60.4-0.40.6-0.5-0.5-0.20.3-1.0-0.31.30.4
Locomotor testing rearing1.72.73.81.6-1.5-1.51.61.6-1.81.6-1.6-1.6-1.41.6-1.9-1.61.91.5
Locomotion in novel chamber0.91.12.7-0.10.60.8-1.0-0.81.1-1.01.11.11.0-1.31.40.9-1.6-0.7
Locomotion in novel chamber post-restriction1.41.74.1-2.01.31.5-1.3-1.21.2-1.11.21.11.0-1.11.41.3-1.6-0.8
Fecal boli incidents, locomotor time 10.40.51.6-1.30.40.8-0.7-0.60.6-0.80.70.70.6-0.70.40.80.0-0.3
Change in fecal boli incidents, locomotor task0.20.21.5-1.20.60.4-0.5-0.30.5-0.20.40.20.1-0.30.30.5-0.4-0.2
Time >=10cm from walls, locomotor time 10.20.21.60.5-0.6-0.00.00.00.00.00.00.1-0.20.00.7-0.2-1.3-0.5
Bouts of movement, locomotor time 10.20.20.5-0.2-0.7-0.20.20.2-0.60.2-0.4-0.5-0.40.4-0.1-0.7-0.10.6
Total resting periods, locomotor time 10.30.30.7-0.2-0.9-0.30.40.3-0.70.4-0.5-0.5-0.50.6-0.1-0.7-0.30.8
Rest time, locomotor task time 10.10.10.2-0.4-0.10.4-0.3-0.30.1-0.40.30.20.2-0.20.10.1-0.10.1
Distance moved, locomotor task time 10.10.10.60.4-0.3-0.50.30.3-0.20.3-0.3-0.3-0.20.1-0.40.00.7-0.5
Vertical activity count, locomotor time 10.10.20.5-0.70.3-0.40.40.4-0.20.5-0.4-0.5-0.20.4-0.20.40.4-0.0
Time >=10cm from walls, locomotor time 20.20.20.7-0.40.50.7-0.6-0.60.4-0.10.40.40.3-0.50.50.3-0.8-0.2
Bouts of movement, locomotor time 20.20.20.60.60.20.6-0.5-0.50.4-0.40.40.50.6-0.40.6-0.1-0.80.1
Total resting periods, locomotor time 20.10.20.40.50.20.5-0.4-0.40.3-0.40.30.40.4-0.30.4-0.2-0.60.1
Rest time, locomotor task time 20.40.50.9-0.80.40.8-0.7-0.70.6-0.90.70.70.8-0.50.70.6-0.4-0.7
Distance moved, locomotor task time 20.00.00.10.1-0.10.0-0.1-0.1-0.10.2-0.1-0.1-0.2-0.00.0-0.2-0.0-0.4
Vertical activity count, locomotor time 20.10.10.3-0.30.2-0.10.20.1-0.30.6-0.3-0.3-0.10.3-0.2-0.10.20.4
Light reinforcement 10.10.21.61.3-0.9-0.00.1-0.1-0.2-0.3-0.3-0.10.20.2-0.2-0.70.4-0.3
Light reinforcement 20.20.21.11.0-0.9-0.0-0.1-0.30.1-0.4-0.10.10.40.10.10.00.3-1.1
Bone: marrow area0.00.00.10.0-0.2-0.30.20.2-0.10.1-0.1-0.1-0.30.1-0.2-0.20.30.0
Bone: maximum diameter4.37.811.83.0-3.3-2.72.72.8-2.82.6-2.7-2.7-2.82.8-2.8-3.42.71.8
Bone: maximum force0.20.31.51.0-1.2-0.50.30.4-0.30.4-0.3-0.3-0.30.2-0.3-0.60.3-0.5
Bone: maximum moment0.20.41.71.1-1.3-0.70.40.5-0.40.6-0.5-0.4-0.40.3-0.5-0.60.5-0.4
Mean time between licks in bursts0.20.22.3-1.50.30.5-0.2-0.20.2-0.10.10.3-0.00.1-0.20.30.6-0.4
Mean num. licks in bursts1.21.56.7-2.61.61.4-1.0-1.01.0-1.01.00.80.6-0.91.11.1-1.0-0.3
Cd content in liver1.01.11.9-0.80.61.1-1.3-1.10.8-1.30.91.11.3-0.61.11.1-0.8-1.4
Co content in liver0.10.10.60.3-0.1-0.20.10.2-0.20.1-0.10.0-0.20.1-0.3-0.30.30.8
Cu content in liver0.00.00.20.2-0.3-0.1-0.00.0-0.4-0.1-0.2-0.1-0.10.4-0.2-0.20.20.4
Fe content in liver0.40.54.9-2.20.90.9-0.5-0.50.4-0.30.30.20.2-0.10.40.6-0.2-0.1
K content in liver0.50.51.81.3-0.5-0.70.60.5-0.80.4-0.6-0.4-0.40.6-0.6-0.60.51.0
Mg content in liver1.81.83.92.0-1.1-1.21.31.2-1.51.1-1.4-1.2-1.21.4-1.3-1.71.11.4
Mn content in liver0.10.10.20.10.5-0.20.0-0.00.0-0.10.20.20.1-0.2-0.30.30.30.5
Na content in liver6.16.48.41.6-2.2-2.62.72.7-2.72.6-2.4-2.5-2.72.5-2.7-2.42.42.9
Rb content in liver1.41.83.21.3-1.8-1.31.21.1-1.61.0-1.4-1.4-1.01.6-1.4-1.11.51.1
Se content in liver1.82.22.91.7-1.2-1.61.61.6-1.61.3-1.5-1.4-1.31.6-1.4-1.61.21.3
Sr content in liver1.21.11.90.8-1.3-1.01.21.2-0.91.3-0.9-1.0-1.40.8-1.1-1.11.10.5
Zn content in liver0.20.31.30.8-0.1-0.30.30.3-0.30.4-0.4-0.2-0.30.3-0.7-0.61.1-0.4
Bone: minimum diameter0.00.10.20.30.10.2-0.3-0.20.3-0.30.30.40.3-0.40.2-0.1-0.2-0.4
Time in familiar zone, hab. session 10.50.51.4-1.0-0.10.5-0.6-0.70.5-0.50.60.60.6-0.30.81.0-0.9-1.2
Time in novel zone, hab. session 10.50.41.21.1-0.1-0.70.60.6-0.50.5-0.6-0.5-0.50.4-0.8-0.80.90.9
Total zone transitions, hab. session 10.40.61.7-1.30.70.8-0.8-0.70.7-0.60.70.70.7-0.60.41.1-0.2-0.4
Total locomotion distance, hab. session 10.10.20.9-0.90.70.3-0.3-0.30.2-0.10.20.20.2-0.2-0.00.60.10.5
Locomotion velocity, hab. session 10.20.31.2-1.10.70.6-0.5-0.40.4-0.40.50.40.3-0.40.20.5-0.20.2
Time in familiar zone, hab. session 23.53.66.1-1.91.41.9-1.9-1.91.9-1.81.91.91.8-1.82.31.8-2.5-1.8
Time in novel zone, hab. session 23.43.46.52.0-1.7-1.81.81.8-1.81.7-1.8-1.8-1.71.7-2.2-1.82.51.1
Total zone transitions, hab. session 20.10.21.3-0.10.2-0.00.20.3-0.10.2-0.1-0.2-0.30.0-0.8-0.11.10.2
Total locomotion distance, hab. session 20.40.61.90.3-0.4-0.50.70.8-0.70.7-0.7-0.8-0.80.8-1.1-0.71.40.4
Locomotion velocity, hab. session 20.70.92.50.5-0.5-0.70.91.0-0.90.9-0.9-1.0-1.00.9-1.3-0.91.60.7
Novel to familiar place preference ratio1.71.83.80.4-0.6-1.21.41.4-1.41.3-1.3-1.4-1.51.3-1.6-1.11.52.0
Novelty place preference1.61.63.40.4-0.6-1.11.31.3-1.31.2-1.2-1.3-1.41.3-1.5-1.11.51.8
Time in novel zone, NPP test1.31.32.70.4-0.6-1.01.21.1-1.21.1-1.1-1.2-1.31.2-1.4-1.01.41.7
Total zone transitions, NPP test0.40.61.0-0.20.80.9-0.9-0.90.8-0.90.90.81.0-0.90.60.7-0.4-0.4
Total locomotion distance, NPP test0.00.10.3-0.10.50.3-0.2-0.20.2-0.30.20.10.3-0.10.10.2-0.00.3
Locomotion velocity, NPP test0.00.10.40.00.4-0.00.10.1-0.1-0.0-0.1-0.20.00.1-0.2-0.00.20.6
Intraocular pressure0.20.20.4-0.3-0.5-0.30.50.5-0.40.5-0.3-0.5-0.60.4-0.6-0.30.70.0
Delta distance traveled before/after self-admin0.20.20.60.8-0.6-0.40.30.4-0.50.7-0.3-0.5-0.60.4-0.2-0.6-0.40.5
Delta ambulatory time before/after self-admin0.10.10.60.00.30.1-0.2-0.10.00.20.10.1-0.1-0.10.3-0.0-0.80.3
Parametrial fat weight1.52.84.4-0.0-1.2-1.61.91.9-1.91.4-1.9-1.9-1.82.1-1.6-1.41.51.9
Pavlov. Cond. lever latency0.40.50.80.1-0.9-0.70.70.7-0.90.8-0.7-0.7-0.80.7-0.6-0.60.50.9
Pavlov. Cond. magazine entry latency1.21.53.2-1.51.81.2-1.1-1.21.3-1.21.21.11.2-1.21.01.4-0.8-1.1
Pavlov. Cond. change in total contacts0.90.92.40.1-0.0-0.91.11.0-0.81.0-1.0-1.1-0.91.0-1.3-0.51.61.0
Pavlov. Cond. index score1.41.83.7-1.31.91.4-1.3-1.31.5-1.41.31.21.3-1.31.21.4-1.0-1.1
Pavlov. Cond. latency score1.31.73.1-1.11.81.3-1.2-1.31.5-1.31.31.21.3-1.31.21.3-1.0-1.2
Pavlov. Cond. lever contacts0.50.61.2-0.41.10.8-0.7-0.70.9-0.80.80.70.8-0.70.70.6-0.5-0.9
Pavlov. Cond. magazine entry number1.41.74.71.9-2.2-1.41.11.2-1.41.2-1.3-1.1-1.11.3-1.0-1.50.70.8
Pavlov. Cond. intertrial magazine entries0.10.11.31.1-0.50.0-0.3-0.3-0.0-0.4-0.00.20.5-0.0-0.0-0.20.10.1
Pavlov. Cond. lever-magazine prob. diff.1.61.93.8-1.22.01.4-1.4-1.41.5-1.41.31.31.4-1.31.31.4-1.1-1.2
Pavlov. Cond. response bias0.30.41.8-0.71.30.6-0.5-0.50.7-0.60.50.40.6-0.60.30.6-0.2-0.3
Pavlov. Cond. lever latency1.82.54.82.2-1.9-1.81.51.5-1.61.4-1.7-1.4-1.21.5-1.6-1.41.50.9
Pavlov. Cond. magazine entry latency0.10.10.60.4-0.8-0.30.20.2-0.20.4-0.1-0.2-0.20.1-0.10.00.00.2
Pavlov. Cond. change in total contacts0.60.81.5-1.20.40.9-0.9-0.90.8-0.81.00.90.8-0.80.91.0-0.8-0.7
Pavlov. Cond. index score0.91.11.6-1.30.91.1-1.0-1.11.1-0.91.21.00.9-1.11.11.1-1.1-0.7
Pavlov. Cond. latency score0.91.21.6-1.21.01.2-1.1-1.11.1-0.91.31.11.0-1.11.11.1-1.1-0.8
Pavlov. Cond. lever contacts2.23.06.3-2.52.11.9-1.6-1.61.8-1.61.81.61.4-1.71.71.7-1.6-1.0
Pavlov. Cond. magazine entry number0.10.10.6-0.30.70.3-0.3-0.30.2-0.50.20.30.3-0.20.10.30.0-0.0
Pavlov. Cond. intertrial magazine entries0.20.31.0-0.51.00.8-0.6-0.60.4-0.60.40.60.5-0.40.20.10.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.91.11.5-1.20.91.1-1.0-1.11.1-0.91.21.00.9-1.11.11.1-1.1-0.8
Pavlov. Cond. response bias0.70.92.4-1.61.21.1-0.8-0.91.0-0.71.10.80.7-1.01.00.9-0.9-0.5
Time in closed arm before self-admin0.20.21.20.3-0.10.3-0.4-0.30.5-0.30.40.50.4-0.40.30.20.1-1.1
Time in closed arm after self-admin4.04.15.1-1.11.92.2-2.3-2.22.1-2.02.12.22.2-2.12.11.6-1.8-2.1
Time in open arm before self-admin0.20.30.5-0.10.70.6-0.5-0.60.4-0.70.50.50.6-0.40.50.2-0.6-0.2
Time in open arm after self-admin1.21.31.80.5-1.4-1.11.31.2-1.11.2-1.1-1.2-1.31.1-1.1-1.30.91.1
Bone: periosteal estimation0.81.63.31.8-1.7-1.31.11.2-1.21.1-1.1-1.1-1.11.1-1.2-1.61.20.5
Bone: periosteal perimeter2.33.96.92.6-2.3-2.01.92.0-2.01.9-1.9-1.8-1.91.9-1.8-2.31.51.5
Bone: post-yield work0.40.50.90.0-0.4-0.90.90.9-0.50.8-0.8-0.9-0.90.6-0.8-0.40.90.6
Progressive ratio test 1 active lever presses1.61.73.60.6-0.8-1.31.31.3-1.41.3-1.5-1.4-1.31.5-1.2-1.10.91.9
Progressive ratio test 1 breakpoint1.01.02.80.5-0.5-1.01.01.0-1.11.0-1.2-1.1-1.01.2-0.8-0.80.41.7
Progressive ratio test 1 inactive lever presses3.13.44.41.5-2.0-1.81.81.7-2.01.7-2.0-1.9-1.52.1-1.9-1.71.92.1
Progressive ratio test 2 active lever presses1.61.72.20.9-1.0-1.41.51.5-1.31.5-1.4-1.4-1.41.4-1.3-1.00.91.4
Progressive ratio test 2 breakpoint1.41.62.10.6-0.8-1.41.41.4-1.31.4-1.2-1.2-1.41.4-1.4-1.01.01.4
Progressive ratio test 2 inactive lever presses4.24.87.12.1-2.7-2.22.42.3-2.22.2-2.3-2.3-2.32.2-2.0-2.41.41.7
Incentive Sensitization - Responses1.31.32.00.7-0.9-1.31.41.4-1.11.3-1.2-1.3-1.31.2-1.1-0.90.70.8
Incentive Sensitization - Breakpoint1.31.32.10.8-1.0-1.31.41.4-1.11.4-1.2-1.3-1.31.2-1.1-1.00.70.8
Sum of active levers in priming session hrs 5-60.90.82.21.1-0.2-0.90.90.9-1.01.1-0.8-0.8-1.01.0-0.7-1.00.11.5
Progressive ratio0.70.81.50.6-1.0-1.20.81.1-0.91.1-1.1-0.9-1.01.1-0.6-0.40.30.4
Food seeking constrained by brief footshock2.83.45.72.1-1.3-2.41.92.0-1.91.9-1.9-2.0-1.51.8-2.0-1.21.61.7
Seeking ratio, punishment vs. effort0.20.20.80.90.2-0.10.30.1-0.2-0.0-0.1-0.20.2-0.1-0.7-0.60.70.6
Retroperitoneal fat weight0.00.10.2-0.2-0.2-0.20.30.2-0.20.2-0.1-0.1-0.30.30.2-0.3-0.4-0.1
Reaction time number correct0.10.10.6-0.60.40.4-0.3-0.20.3-0.10.40.40.1-0.40.00.20.3-0.8
Reaction time mean minus median0.20.20.5-0.10.4-0.20.70.4-0.10.5-0.6-0.7-0.50.4-0.0-0.6-0.20.5
Reaction time mean minus median AUC0.20.30.80.8-0.3-0.40.70.4-0.40.6-0.7-0.7-0.40.5-0.2-0.9-0.10.4
Reaction time num false alarms0.40.61.61.2-0.9-0.90.80.8-0.80.6-0.7-0.7-0.60.6-0.5-0.70.30.8
Reaction time num false alarms AUC0.40.52.31.5-0.9-0.80.70.6-0.70.4-0.6-0.6-0.40.5-0.4-0.60.10.5
Reaction time trials correct on left0.10.10.6-0.60.40.4-0.3-0.20.3-0.10.40.40.1-0.40.00.20.3-0.8
Reaction time trials on left0.10.20.6-0.60.50.5-0.4-0.30.4-0.20.50.40.2-0.40.10.20.2-0.8
Reaction time mean0.10.10.4-0.00.50.20.2-0.20.2-0.0-0.3-0.40.00.00.3-0.2-0.60.3
Reaction time mean AUC0.10.10.70.00.70.3-0.0-0.50.4-0.2-0.1-0.20.3-0.20.5-0.0-0.80.1
Median of all reaction times0.10.10.5-0.00.60.3-0.1-0.50.3-0.3-0.0-0.10.3-0.20.50.0-0.70.1
Reaction time omissions0.30.51.6-0.41.10.6-0.5-0.60.6-0.50.60.50.6-0.70.90.6-1.3-0.1
Reaction time false alarm rate0.50.73.31.8-1.1-1.00.80.7-0.80.5-0.8-0.7-0.50.6-0.3-0.7-0.10.9
Reaction time premature initiation rate5.77.69.3-2.12.52.8-2.8-2.82.9-3.03.02.92.9-3.12.72.6-2.4-2.6
Reaction time premature initiations3.95.56.9-2.12.22.5-2.4-2.42.5-2.52.62.52.4-2.62.12.2-1.7-2.5
Std. dev. reaction times0.20.20.70.20.2-0.20.70.4-0.20.5-0.7-0.9-0.50.5-0.1-0.7-0.20.4
Reaction time trials completed0.10.20.6-0.60.50.5-0.4-0.30.4-0.20.50.40.2-0.40.10.20.2-0.8
Reaction time trials AUC0.10.10.5-0.50.40.4-0.3-0.20.3-0.10.40.30.1-0.3-0.10.10.5-0.7
Run reversals in cocaine runway, females0.20.21.1-0.80.1-0.20.30.20.0-0.1-0.4-0.50.10.20.80.5-1.0-0.2
Run reversals in cocaine runway, males0.00.00.10.20.2-0.20.30.1-0.20.1-0.3-0.3-0.20.40.1-0.2-0.0-0.2
Latency to leave start box in cocaine runway0.10.10.30.1-0.6-0.30.10.2-0.50.0-0.4-0.30.00.50.00.3-0.20.6
Latency to leave start box in cocaine runway, F0.20.21.21.0-1.1-0.40.20.2-0.40.1-0.4-0.30.10.50.2-0.1-0.6-0.1
Latency to leave start box in cocaine runway, M0.30.31.5-1.20.60.1-0.1-0.1-0.1-0.10.10.00.0-0.0-0.40.60.81.0
Std. dev. time between licks in bursts0.80.92.0-1.40.91.1-1.0-1.10.9-0.80.91.01.0-0.90.51.2-0.1-0.9
Total sessions with >9 infusions0.10.10.20.00.40.4-0.5-0.40.4-0.50.20.40.5-0.30.50.3-0.4-0.3
Short access day 1 total inactive lever presses1.82.04.21.4-1.7-1.41.21.1-1.51.2-1.4-1.3-1.01.6-1.8-1.12.01.1
Short access day 10 total inactive lever presses1.21.31.9-0.71.11.3-1.2-1.31.2-1.41.21.11.4-1.31.01.0-0.8-0.7
Short access day 1 total infusions0.00.10.30.5-0.20.1-0.1-0.2-0.0-0.2-0.1-0.00.40.00.20.1-0.30.1
Short access day 10 total infusions0.10.10.3-0.10.40.1-0.3-0.20.4-0.20.20.30.3-0.20.30.5-0.3-0.2
Short access total infusions0.00.00.20.4-0.00.0-0.2-0.20.1-0.2-0.00.10.40.00.10.3-0.2-0.1
Short access day 1 locomotion1.71.92.6-0.41.01.4-1.4-1.51.5-1.41.21.31.6-1.41.51.5-1.3-1.6
Short access day 10 total locomotion2.22.55.1-2.21.71.5-1.6-1.51.6-1.41.41.61.4-1.41.32.3-1.0-0.9
Short access total locomotion5.55.77.7-2.12.32.5-2.5-2.62.6-2.42.42.42.5-2.52.22.8-1.8-2.2
One hour access (0.3 mA shock)0.80.91.50.5-0.7-1.01.21.0-1.01.0-1.1-1.1-1.01.1-0.8-0.70.61.2
Compulsive drug intake6.16.27.6-2.32.82.6-2.6-2.52.4-2.62.52.42.5-2.52.72.3-2.7-1.6
One hour access (shock baseline)5.36.27.41.8-2.2-2.62.72.6-2.52.6-2.6-2.6-2.62.6-2.6-2.22.32.5
Social response proportion0.50.61.90.3-0.6-0.40.60.8-0.60.8-0.6-0.7-1.00.6-1.0-0.81.40.2
Social responses0.70.92.40.5-0.8-0.70.91.0-0.71.1-0.7-0.9-1.30.7-1.2-1.11.60.3
Social time0.10.10.4-0.60.60.3-0.3-0.20.40.00.40.2-0.0-0.40.50.2-0.5-0.5
Soleus weight0.72.05.62.4-2.0-1.61.11.2-1.31.3-1.2-1.0-1.01.3-1.4-1.31.50.4
Bone: stiffness0.10.10.2-0.1-0.10.4-0.4-0.40.2-0.50.30.40.4-0.30.40.1-0.4-0.4
Tibialis anterior weight1.96.58.02.6-2.8-2.82.52.7-2.72.5-2.5-2.5-2.52.6-2.6-2.62.42.0
Time to tail flick, vehicle, before self-admin0.30.31.21.1-0.7-0.50.40.5-0.40.6-0.4-0.4-0.50.3-0.2-0.5-0.30.3
Time to tail flick, vehicle, after self-admin0.20.20.9-0.70.20.1-0.2-0.10.3-0.10.30.20.2-0.30.50.8-0.90.2
Time to tail flick, test, before self-admin1.51.42.2-0.81.31.4-1.2-1.21.3-1.11.51.51.1-1.51.11.0-1.0-1.0
Time to tail flick, test, after self-admin1.11.23.81.6-1.2-1.00.81.0-1.00.9-0.8-0.6-0.80.8-1.5-0.91.90.1
Delta time to tail flick, vehicle, before/after SA0.30.31.6-1.30.40.3-0.2-0.30.4-0.40.40.30.3-0.30.51.0-0.50.1
Delta time to tail flick, test, before/after SA1.71.52.81.3-1.3-1.21.11.1-1.31.0-1.3-1.2-1.01.3-1.4-1.31.70.6
Tibia length0.20.41.40.60.00.2-0.7-0.50.5-0.70.40.60.8-0.40.90.5-1.0-1.2
Ambulatory time before self-admin0.20.20.9-0.60.4-0.40.40.20.00.2-0.3-0.50.10.2-0.30.90.70.4
Ambulatory time after self-admin0.30.30.7-0.60.2-0.60.70.5-0.40.5-0.7-0.8-0.30.7-0.40.50.60.7
Bone: tissue strength0.20.11.50.2-0.60.0-0.1-0.10.3-0.10.10.10.0-0.20.1-0.20.1-1.2
Total heroin consumption0.00.00.10.20.20.1-0.2-0.20.3-0.10.20.10.2-0.20.1-0.10.10.2
Bone: trabecular number0.30.51.1-0.11.00.5-0.7-0.60.8-0.70.70.70.9-0.90.40.7-0.2-0.3
Bone: trabecular spacing1.31.74.00.8-2.0-1.31.31.4-1.41.4-1.4-1.3-1.41.5-1.1-1.20.90.5
Bone: trabecular thickness2.12.66.3-0.82.51.4-1.6-1.61.8-1.51.81.61.6-2.01.41.5-1.1-1.1
Bone: trabecular tissue density0.00.10.5-0.70.20.10.00.00.10.10.0-0.1-0.20.00.2-0.0-0.3-0.0
Water consumed over 24 hours0.20.21.2-1.1-0.3-0.20.30.3-0.30.3-0.2-0.3-0.50.5-0.60.11.0-0.1
Number of responses in last shaping day0.20.20.6-0.50.30.4-0.4-0.50.5-0.40.20.10.5-0.30.70.5-0.8-0.3