Hub : Genes

Serpine3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Serpine3	0.06	0.03	1.9e-07	0.07	0.07	0.08	0.08	1.9e-07	2.2e-07	1.2e-07	8.5e-08
2	NAcc	gene expression	Serpine3	0.03	0.02	3.0e-03	0.02	0.01	0.01	0.01	1.6e-03	6.9e-03	1.0e-02	9.0e-03
3	IC	mRNA stability	Serpine3	0.06	0.04	6.1e-03	0.04	0.03	0.03	0.04	6.5e-03	3.2e-02	3.2e-02	1.2e-02
4	PL	gene expression	Serpine3	0.03	0.02	1.5e-03	-0	0.02	0	0	6.7e-01	4.9e-03	1.3e-01	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.4	0.6	-0.4	-0.7	-0.1
Area under the delay curve	2.6	4.1	5.1	-2.3	1.9	1.9	-2.0
BMI with tail	0.9	3.1	5.0	-1.9	1.7	2.2	-0.8
BMI without tail	0.1	0.3	0.4	-0.6	0.6	0.5	0.4
Body weight	1.4	6.2	6.6	-2.6	2.6	2.4	-2.4
Weight adjusted by age	0.8	2.2	2.7	-1.5	1.4	1.4	-1.6
Bone surface	0.2	0.5	0.8	0.8	-0.6	-0.9	-0.3
Bone volume	0.1	0.3	0.7	0.5	-0.3	-0.8	-0.3
Breakpoint value in progressive ratio session	0.2	0.4	0.8	-0.4	0.6	0.7	-0.9
Number of licking bursts	0.1	0.2	0.3	-0.5	0.5	0.4	0.4
Context. condit. distance diff. score	0.4	0.5	1.7	0.1	-0.2	-0.5	1.3
Locomotion velocity, session 1	1.3	1.5	1.9	-1.2	1.1	1.2	-1.4
Locomotion distance, session 1	1.3	1.7	2.5	-1.3	1.3	1.0	-1.6
Locomotion velocity, session 2	0.9	1.0	1.6	-1.1	1.3	0.3	-1.1
Locomotion distance, session 2	0.3	0.4	1.2	-0.3	0.7	-0.0	-1.1
Locomotion velocity, session 3	1.2	1.4	2.1	-1.3	1.4	1.0	-0.9
Locomotion distance, session 3	1.3	1.5	2.8	-1.5	1.7	0.7	-0.7
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	1.3	-1.3	-0.8	0.8
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	-0.3	0.4	-0.2
Locomotion velocity, session 7	0.4	0.4	1.0	-0.2	0.5	-0.6	1.0
Locomotion distance, session 7	2.0	2.5	3.8	1.3	-1.2	-1.9	1.8
Stereotopy head waving bouts, day 7	2.7	3.2	4.8	-1.5	1.5	2.2	-1.8
Stereotopy head waving duration, day 7	3.9	4.9	6.9	-2.1	2.1	2.6	-1.9
Locomotion velocity, session 8	0.8	1.0	1.9	-1.1	1.4	0.2	-0.9
Locomotion distance, session 8	0.1	0.2	0.4	-0.5	0.6	-0.1	-0.2
Degree of sensitization distance	7.3	7.9	8.5	2.9	-2.9	-2.6	2.8
Degree of sensitization stereotypy	3.5	3.9	4.8	-1.9	1.8	2.2	-2.0
Conditioned locomotion	0.5	0.6	1.9	0.4	-0.3	-1.4	0.4
Cocaine response after cond. corrected	0.5	0.7	2.5	0.3	-0.4	-0.5	1.6
Cocaine response after cond. not corrected	0.4	0.6	2.0	0.2	-0.4	-0.5	1.4
Cocaine response before conditioning	0.6	0.7	1.5	-0.6	0.6	0.8	-1.2
Saline control response	0.3	0.4	1.0	0.5	-0.6	0.2	-1.0
Bone: connectivity density	0.4	0.7	1.2	1.1	-0.9	-0.9	0.3
Bone: cortical apparent density	0.7	1.2	2.8	-1.0	0.8	1.7	0.4
Bone: cortical area	0.0	0.0	0.1	-0.2	0.1	0.3	-0.0
Bone: cortical porosity	2.3	2.4	3.8	-1.5	1.6	1.1	-1.9
Bone: cortical porosity	2.5	2.8	5.3	-1.5	1.5	1.3	-2.3
Bone: cortical thickness	0.4	0.6	1.3	-0.8	0.6	1.1	-0.3
Bone: cortical thickness	1.2	1.5	2.1	-1.4	1.3	1.4	-0.2
Bone: cortical tissue density	0.7	1.1	2.6	-1.0	0.8	1.6	0.4
Condit. Reinf. active minus inactive responses	1.5	1.7	2.7	-1.0	1.1	1.3	-1.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	-0.2	0.1	0.2
Condit. Reinf. active responses	2.2	2.9	5.1	-1.4	1.3	1.6	-2.2
Condit. Reinf. inactive responses	1.6	2.0	4.3	-1.2	1.1	1.1	-2.1
Incentive salience index mean	2.9	3.7	5.4	-1.7	1.7	1.9	-2.3
Condit. Reinf. lever presses	3.2	4.9	6.3	-2.1	2.0	2.2	-2.5
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	-0.3	0.1	0.3	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	-0.5	0.3	0.9	0.0
Condit. Reinf. active responses	0.2	0.3	0.4	-0.6	0.4	0.6	-0.3
Condit. Reinf. inactive responses	0.3	0.4	0.7	0.6	-0.7	-0.8	0.2
Condit. Reinf. lever presses	2.9	4.2	4.8	-2.0	2.0	2.2	-2.1
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	-0.8	0.6	1.0	-0.6
Conditioned reinforcement - actives	2.3	9.1	11.9	3.2	-3.4	-3.0	2.3
Conditioned reinforcement - inactives	2.4	6.7	7.9	2.7	-2.6	-2.8	2.0
Conditioned locomotion	2.4	3.6	4.4	1.7	-2.1	-1.9	1.9
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.2	-0.0	-0.5	-0.7
Patch foraging indifference point AUC	0.3	0.7	2.8	0.1	-0.4	-0.0	1.7
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.5	0.5	0.4	-0.8
Delay disc. indifference point, 16s delay	0.8	1.1	1.8	-1.4	1.1	0.6	-1.0
Delay disc. indifference point, 2s delay	2.1	2.3	2.9	-1.4	1.4	1.7	-1.6
Delay disc. indifference point, 24s delay	0.4	0.7	1.1	-1.1	0.9	0.8	-0.3
Delay disc. indifference point, 4s delay	3.9	4.2	5.5	-2.1	1.9	1.8	-2.3
Delay disc. indifference point, 8s delay	1.8	2.9	4.2	-2.0	1.7	1.6	-1.5
Indifference point function ln k	0.3	1.0	2.9	-0.6	0.7	0.5	-1.7
Indifference point function log k	0.3	1.0	2.9	-0.6	0.7	0.5	-1.7
Patch foraging total patch changes 0 sec	0.1	0.3	1.1	-0.2	0.4	0.0	-1.0
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.7	0.7	0.7	-0.2
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.0	-0.1	0.3	0.4
Patch foraging total patch changes 24 sec	0.2	0.6	0.7	-0.8	0.8	0.5	-0.8
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.1	0.0	0.0	0.6
Patch foraging time to switch 0 sec	0.0	0.2	0.5	0.4	-0.1	-0.7	0.2
Patch foraging water rate 0 sec	0.4	1.6	1.9	-1.4	1.2	1.2	-1.3
Patch foraging water rate 12 sec	1.2	4.9	7.7	-2.1	2.0	2.0	-2.8
Patch foraging water rate 18 sec	4.0	8.8	10.6	-3.3	3.3	2.6	-2.7
Patch foraging water rate 24 sec	0.9	1.2	2.7	-0.9	0.8	0.9	-1.7
Patch foraging water rate 6 sec	2.4	3.6	5.7	-1.8	1.6	1.7	-2.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.7	0.8	-1.0	-1.3	0.2
Distance traveled before self-admin	0.2	0.3	1.0	-0.1	0.2	0.5	-1.0
Distance traveled after self-admin	0.1	0.2	0.3	0.2	-0.4	-0.3	-0.6
Extensor digitorum longus weight	7.7	30.5	33.5	-5.8	5.8	5.6	-4.8
Bone: elastic displacement	0.3	0.4	0.8	0.6	-0.4	-0.9	-0.5
Bone: elastic work	0.5	0.6	2.2	-0.3	0.4	0.2	-1.5
Bone: endosteal estimation	0.4	0.9	1.8	1.0	-0.8	-1.3	0.1
Bone: endosteal perimeter	0.8	1.9	3.6	1.5	-1.3	-1.9	0.3
Epididymis fat weight	0.1	0.4	1.5	-0.3	0.2	0.4	-1.2
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.0	-0.1	0.3	0.1
Delta time in open arm before/after self-admin	1.3	1.6	2.2	0.8	-1.1	-1.4	1.5
Diff in mean of infusions in LGA sessions	0.3	0.5	1.2	-0.3	0.7	0.0	-1.1
Delay discount exponential model param	4.0	5.5	6.8	2.6	-2.3	-2.3	2.2
Extinction: sum of active levers before priming	0.0	0.1	0.2	-0.0	0.2	0.2	-0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	0.0	0.1	-0.1
Bone: final force	0.9	1.4	1.9	-1.1	1.1	1.2	-1.4
Bone: final moment	1.2	1.9	3.0	-1.2	1.2	1.3	-1.7
Food consumed during 24 hour testing period	0.1	0.3	0.6	-0.3	0.3	0.8	-0.7
Glucose	0.1	0.1	0.2	-0.5	0.5	0.2	0.3
Heart weight	0.0	0.1	0.2	-0.2	-0.1	0.4	-0.0
Delay discount hyperbolic model param	3.8	4.9	5.9	2.4	-2.1	-2.2	2.2
Intermittent access intake day 1-15 change	0.5	2.8	4.2	2.0	-2.1	-1.3	1.1
Intermittent access intake escalation	0.3	1.9	2.9	1.7	-1.7	-0.9	0.9
Intermittent access intake escalation 2	0.8	1.3	1.6	1.2	-1.3	-0.9	1.1
Intermitt. access day 1 inactive lever presses	0.7	8.7	9.0	3.0	-3.0	-3.0	2.8
Intermitt. access day 15 inactive lever presses	0.4	2.1	2.7	1.6	-1.6	-1.5	0.8
Intermitt. access escalation Index	0.0	0.1	0.2	-0.4	0.2	0.4	0.4
Intermittent access day 1 total infusions	0.4	1.3	1.4	1.2	-1.2	-1.1	1.0
Intermittent access day 15 total infusions	1.7	4.3	5.3	2.3	-2.3	-2.0	1.6
Intermittent access terminal intake (last 3 days)	2.6	4.6	5.1	2.3	-2.2	-2.1	2.1
Intermittent access total infusions	4.9	5.8	6.7	2.5	-2.6	-2.3	2.2
Intermittent access day 1 locomotion	0.2	0.3	0.5	0.4	-0.5	-0.7	0.6
Intermittent access day 15 total locomotion	0.8	3.2	3.7	1.9	-1.9	-1.7	1.6
Intermittent access total locomotion	2.0	2.4	2.9	1.7	-1.7	-1.5	1.4
Intermittent access standard deviation	0.2	1.2	1.9	1.4	-1.4	-1.1	-0.0
Left kidney weight	0.8	6.6	7.3	-2.7	2.6	2.4	-2.6
Right kidney weight	1.8	12.7	14.1	-3.5	3.4	3.8	-3.6
Cocaine induced anxiety	0.6	1.5	2.1	-1.2	1.1	1.1	-1.5
Post-drug Anxiety	0.4	0.5	1.6	-0.4	0.4	0.4	-1.3
Baseline Anxiety	0.0	0.1	0.2	0.4	-0.3	-0.1	0.2
Tail length	0.1	0.4	1.4	-0.2	0.5	0.2	-1.2
Length with tail	0.2	1.0	3.4	-0.2	0.6	-0.1	-1.9
Length without tail	0.5	2.6	5.6	-1.3	1.4	1.1	-2.4
Times rat made contact with spout	0.4	0.4	0.7	-0.6	0.8	0.4	-0.7
Lifetime Intake	4.6	5.7	6.4	2.5	-2.5	-2.4	2.1
Liver weight, left	1.8	3.1	4.5	-1.5	1.4	1.8	-2.1
Liver weight, right	0.1	0.2	0.4	-0.6	0.5	0.0	-0.3
Locomotor activity	4.5	7.1	11.0	-2.3	2.6	2.3	-3.3
Locomotor testing distance	0.5	1.2	4.1	-0.1	0.5	0.5	-2.0
Locomotor testing rearing	0.3	1.2	3.9	-0.2	0.7	0.7	-2.0
Locomotion in novel chamber	1.9	2.6	3.5	-1.4	1.9	1.7	-1.5
Locomotion in novel chamber post-restriction	0.1	0.3	0.5	-0.7	0.6	-0.2	-0.6
Fecal boli incidents, locomotor time 1	1.2	3.1	4.1	-2.0	2.0	1.9	-0.8
Change in fecal boli incidents, locomotor task	1.0	1.0	2.4	1.0	-0.7	-1.6	0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.2	0.0	0.2	0.4	-1.1
Bouts of movement, locomotor time 1	0.5	0.6	0.9	-0.9	0.9	0.8	-0.6
Total resting periods, locomotor time 1	0.4	0.4	0.6	-0.8	0.8	0.7	-0.1
Rest time, locomotor task time 1	0.9	1.4	2.2	-1.4	1.3	1.5	0.1
Distance moved, locomotor task time 1	0.4	1.2	1.6	1.3	-1.3	-1.2	0.2
Vertical activity count, locomotor time 1	0.1	1.0	1.5	1.2	-0.8	-1.2	-0.7
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.3	-0.3	-0.5	-0.7
Bouts of movement, locomotor time 2	0.1	0.3	0.7	-0.8	0.8	0.3	0.1
Total resting periods, locomotor time 2	0.1	0.6	1.1	-1.0	1.0	0.5	0.1
Rest time, locomotor task time 2	1.2	2.0	3.2	-1.8	1.7	1.3	-0.3
Distance moved, locomotor task time 2	0.2	0.3	0.4	0.6	-0.6	-0.4	-0.6
Vertical activity count, locomotor time 2	0.3	0.7	1.1	1.0	-0.9	-0.5	-0.7
Light reinforcement 1	0.3	1.4	1.6	-1.0	1.2	1.1	-1.3
Light reinforcement 2	0.2	0.5	0.8	0.5	-0.5	-0.9	0.9
Bone: marrow area	0.4	0.9	1.9	1.0	-0.9	-1.4	0.1
Bone: maximum diameter	0.4	0.8	1.7	0.7	-0.7	-1.3	0.7
Bone: maximum force	0.7	1.4	2.6	-0.9	1.0	1.0	-1.6
Bone: maximum moment	1.0	1.8	3.8	-1.0	1.1	1.2	-1.9
Mean time between licks in bursts	0.1	0.8	1.2	0.9	-0.9	-0.5	1.1
Mean num. licks in bursts	0.1	0.2	0.7	0.0	0.1	-0.1	-0.9
Cd content in liver	0.5	0.5	1.3	-0.4	0.5	0.6	-1.2
Co content in liver	0.7	0.8	1.1	-1.0	1.0	0.6	-0.8
Cu content in liver	1.7	2.0	2.4	-1.5	1.5	1.5	-1.1
Fe content in liver	0.7	0.8	1.4	1.2	-1.1	-0.6	0.5
K content in liver	0.3	0.2	0.5	0.3	-0.3	-0.5	0.7
Mg content in liver	1.6	1.8	2.3	1.4	-1.3	-1.5	1.1
Mn content in liver	1.0	1.1	1.6	1.3	-1.3	-0.9	0.7
Na content in liver	2.3	2.6	4.0	-1.5	1.4	1.5	-2.0
Rb content in liver	2.5	2.9	4.0	2.0	-1.8	-1.7	1.2
Se content in liver	1.7	2.0	3.3	1.5	-1.5	-1.8	0.4
Sr content in liver	0.6	0.5	0.7	0.6	-0.6	-0.7	0.8
Zn content in liver	0.2	0.2	0.4	0.4	-0.3	-0.7	0.0
Bone: minimum diameter	0.1	0.2	0.3	0.5	-0.4	-0.6	-0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.2	0.1	0.8	-0.2
Time in novel zone, hab. session 1	0.2	0.3	0.7	0.4	-0.2	-0.8	0.5
Total zone transitions, hab. session 1	0.8	1.1	1.7	-1.3	1.3	0.7	-0.8
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.3	0.3	0.0	-0.4
Locomotion velocity, hab. session 1	0.3	0.4	1.2	-0.5	0.5	0.3	-1.1
Time in familiar zone, hab. session 2	0.3	0.4	0.6	0.7	-0.8	-0.5	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.6	0.8	0.3	-0.2
Total zone transitions, hab. session 2	2.9	3.7	4.7	-2.1	2.2	1.3	-2.0
Total locomotion distance, hab. session 2	1.6	2.0	3.0	-1.6	1.7	0.7	-1.5
Locomotion velocity, hab. session 2	1.7	2.3	3.0	-1.6	1.7	0.8	-1.7
Novel to familiar place preference ratio	1.1	1.5	2.4	1.3	-1.1	-1.5	0.8
Novelty place preference	1.0	1.3	2.1	1.2	-1.0	-1.5	0.6
Time in novel zone, NPP test	0.9	1.1	2.0	1.2	-1.0	-1.4	0.5
Total zone transitions, NPP test	1.2	1.8	2.1	-1.4	1.4	1.0	-1.4
Total locomotion distance, NPP test	0.1	0.1	0.3	0.1	0.0	-0.5	-0.0
Locomotion velocity, NPP test	0.0	0.0	0.2	0.0	0.1	-0.4	0.0
Intraocular pressure	1.6	2.6	3.8	2.0	-1.9	-1.6	0.8
Delta distance traveled before/after self-admin	1.1	1.2	1.5	0.8	-1.2	-1.2	1.1
Delta ambulatory time before/after self-admin	0.5	0.9	1.2	0.7	-1.1	-1.1	0.9
Parametrial fat weight	1.3	3.1	5.1	1.9	-1.8	-2.3	0.9
Pavlov. Cond. lever latency	1.1	1.4	1.7	1.3	-1.1	-1.3	1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	-0.5	0.1	-0.1
Pavlov. Cond. change in total contacts	0.7	0.7	1.4	-0.7	0.5	0.8	-1.2
Pavlov. Cond. index score	1.7	2.2	2.5	-1.6	1.4	1.5	-1.4
Pavlov. Cond. latency score	1.4	1.7	2.1	-1.4	1.2	1.4	-1.2
Pavlov. Cond. lever contacts	0.9	1.1	1.4	-1.2	1.0	1.0	-1.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.3	0.9	-0.7	-1.1	1.1
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.3	-1.1	1.1	1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	2.5	-1.6	1.4	1.5	-1.4
Pavlov. Cond. response bias	1.0	1.2	1.4	-1.2	1.0	1.2	-1.1
Pavlov. Cond. lever latency	3.4	4.8	5.2	2.1	-2.2	-2.2	2.3
Pavlov. Cond. magazine entry latency	1.6	2.3	3.3	-1.3	1.3	1.6	-1.8
Pavlov. Cond. change in total contacts	2.4	5.9	6.0	-2.4	2.4	2.4	-2.4
Pavlov. Cond. index score	3.3	5.1	5.8	-2.2	2.2	2.3	-2.4
Pavlov. Cond. latency score	3.1	4.9	5.9	-2.1	2.0	2.3	-2.4
Pavlov. Cond. lever contacts	3.6	5.3	5.9	-2.2	2.3	2.3	-2.4
Pavlov. Cond. magazine entry number	1.9	2.5	2.8	1.6	-1.6	-1.7	1.6
Pavlov. Cond. intertrial magazine entries	1.6	3.5	3.9	2.0	-1.8	-1.9	1.8
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.7	5.3	-2.1	2.0	2.3	-2.3
Pavlov. Cond. response bias	4.3	5.9	6.6	-2.3	2.4	2.4	-2.6
Time in closed arm before self-admin	0.6	1.1	1.4	-1.2	1.1	1.1	-0.7
Time in closed arm after self-admin	2.2	2.5	3.7	-1.6	1.4	1.9	-1.3
Time in open arm before self-admin	0.4	0.5	1.7	0.0	0.4	0.4	-1.3
Time in open arm after self-admin	0.6	0.7	0.9	0.8	-0.8	-1.0	0.8
Bone: periosteal estimation	0.2	0.5	0.9	0.8	-0.7	-0.9	0.3
Bone: periosteal perimeter	0.2	0.4	0.7	0.6	-0.6	-0.8	0.3
Bone: post-yield work	0.1	0.2	0.7	-0.2	0.1	-0.2	0.8
Progressive ratio test 1 active lever presses	0.9	1.5	1.7	1.2	-1.2	-1.2	1.3
Progressive ratio test 1 breakpoint	0.7	1.3	1.6	1.1	-1.1	-1.1	1.3
Progressive ratio test 1 inactive lever presses	0.9	2.3	3.0	1.6	-1.3	-1.7	1.5
Progressive ratio test 2 active lever presses	2.5	3.6	4.4	2.0	-1.9	-1.5	2.1
Progressive ratio test 2 breakpoint	2.3	2.9	3.4	1.8	-1.8	-1.4	1.9
Progressive ratio test 2 inactive lever presses	1.5	4.9	5.8	2.3	-2.3	-1.8	2.4
Incentive Sensitization - Responses	0.8	2.1	3.2	1.8	-1.6	-0.9	1.4
Incentive Sensitization - Breakpoint	0.8	1.9	2.9	1.7	-1.5	-0.9	1.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	-0.2	-0.4	0.5
Progressive ratio	0.1	0.3	0.4	-0.6	0.6	0.4	-0.6
Food seeking constrained by brief footshock	1.1	1.4	3.6	0.8	-1.1	-0.6	1.9
Seeking ratio, punishment vs. effort	0.1	0.3	0.8	0.3	-0.6	-0.1	0.9
Retroperitoneal fat weight	0.0	0.0	0.1	0.0	0.0	-0.0	-0.3
Reaction time number correct	0.0	0.0	0.1	0.3	-0.1	0.0	0.2
Reaction time mean minus median	0.0	0.2	0.5	0.0	-0.2	0.4	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.2	0.1	-0.4	0.5	-0.0
Reaction time num false alarms	0.4	0.7	1.5	-0.4	0.7	0.6	-1.2
Reaction time num false alarms AUC	0.4	1.0	1.5	-0.7	1.0	1.0	-1.2
Reaction time trials correct on left	0.0	0.0	0.1	0.3	-0.1	0.0	0.2
Reaction time trials on left	0.0	0.1	0.1	0.4	-0.2	-0.0	0.3
Reaction time mean	0.4	0.8	1.3	1.1	-1.1	-0.9	0.3
Reaction time mean AUC	0.3	0.8	1.3	1.1	-1.1	-0.9	0.3
Median of all reaction times	0.7	1.1	1.5	1.2	-1.2	-1.1	0.5
Reaction time omissions	1.9	3.0	4.2	1.9	-1.8	-1.1	2.1
Reaction time false alarm rate	0.6	0.9	1.1	-0.8	1.1	0.9	-1.0
Reaction time premature initiation rate	0.4	0.6	0.8	-0.6	0.7	0.8	-0.9
Reaction time premature initiations	0.1	0.2	0.2	-0.2	0.3	0.5	-0.5
Std. dev. reaction times	0.2	0.6	1.0	0.8	-1.0	-0.6	0.4
Reaction time trials completed	0.0	0.1	0.1	0.4	-0.2	-0.0	0.3
Reaction time trials AUC	0.0	0.1	0.2	0.4	-0.2	-0.1	0.3
Run reversals in cocaine runway, females	0.7	0.8	1.3	1.1	-1.1	-0.7	0.2
Run reversals in cocaine runway, males	0.9	1.0	1.7	-0.8	0.5	1.2	-1.3
Latency to leave start box in cocaine runway	0.6	0.9	1.2	0.9	-1.0	-1.1	0.7
Latency to leave start box in cocaine runway, F	1.5	1.9	2.6	1.3	-1.4	-1.6	1.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.4	0.5	0.5	-0.4
Std. dev. time between licks in bursts	1.6	3.1	4.8	2.1	-2.2	-1.6	0.8
Total sessions with >9 infusions	2.8	3.5	4.1	1.9	-2.0	-2.0	1.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.1	0.0	-0.4	-0.0
Short access day 10 total inactive lever presses	0.0	0.2	0.7	0.3	-0.3	-0.2	0.8
Short access day 1 total infusions	2.2	4.3	6.1	1.9	-2.0	-2.5	1.9
Short access day 10 total infusions	0.5	0.8	1.2	0.9	-1.1	-1.1	0.2
Short access total infusions	2.1	3.0	3.7	1.7	-1.9	-1.9	1.3
Short access day 1 locomotion	0.2	0.3	0.8	0.3	-0.4	-0.9	0.6
Short access day 10 total locomotion	0.0	0.2	0.5	-0.2	0.1	0.7	-0.3
Short access total locomotion	0.0	0.1	0.1	0.1	-0.4	-0.3	0.1
One hour access (0.3 mA shock)	2.5	2.9	4.1	1.7	-2.0	-1.2	1.8
Compulsive drug intake	1.5	2.2	3.3	-1.5	1.6	1.8	-0.8
One hour access (shock baseline)	2.2	5.8	7.4	2.5	-2.7	-2.5	1.8
Social response proportion	2.3	2.9	3.9	1.7	-1.4	-2.0	1.7
Social responses	1.5	2.0	3.1	1.8	-1.6	-1.2	1.0
Social time	0.8	1.3	2.4	-1.0	1.6	1.0	-0.8
Soleus weight	0.5	1.4	2.9	-1.2	1.0	1.7	-0.2
Bone: stiffness	0.2	0.4	0.6	-0.7	0.8	0.6	-0.5
Tibialis anterior weight	8.1	27.8	31.9	-5.6	5.7	5.3	-4.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.1	-0.4	0.1	-0.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	0.4	-0.2	-0.1
Time to tail flick, test, before self-admin	0.7	0.8	1.1	-0.7	1.0	1.0	-0.8
Time to tail flick, test, after self-admin	2.4	2.6	3.6	1.9	-1.8	-1.2	1.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.1	0.6	-0.3	0.6
Delta time to tail flick, test, before/after SA	2.5	3.2	4.1	1.8	-2.0	-1.6	1.6
Tibia length	0.9	2.6	4.7	-1.3	1.5	1.3	-2.2
Ambulatory time before self-admin	0.3	0.9	1.9	-0.6	0.8	0.9	-1.4
Ambulatory time after self-admin	0.4	0.6	1.6	-0.6	0.6	0.4	-1.3
Bone: tissue strength	0.3	0.4	0.6	0.8	-0.7	-0.6	0.0
Total heroin consumption	0.5	0.6	1.6	-0.4	0.4	1.2	-0.7
Bone: trabecular number	0.4	0.7	1.4	0.9	-0.8	-1.2	0.1
Bone: trabecular spacing	0.3	0.4	0.7	-0.8	0.6	0.8	-0.1
Bone: trabecular thickness	0.7	1.0	1.3	-1.0	1.1	0.7	-1.2
Bone: trabecular tissue density	0.7	1.2	2.0	-1.4	1.2	1.1	-0.3
Water consumed over 24 hours	0.2	0.4	1.0	-0.5	0.5	0.3	-1.0
Number of responses in last shaping day	0.7	0.9	2.2	0.7	-0.9	-1.5	-0.0