Selenow

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Selenow	0.63	0.12	0.0e+00	0.22	0.24	0.23	0.23	2.4e-24	1.3e-26	2.1e-25	2.0e-25
2	Adipose	gene expression	Selenow	0.3	0.18	1.2e-14	0.12	0.12	0.11	0.12	5.6e-13	3.0e-13	3.1e-12	5.6e-13
3	NAcc	gene expression	Selenow	0.03	0.02	2.2e-05	0.03	0.03	0.03	0.03	3.3e-05	1.5e-05	5.2e-05	2.2e-05
4	Brain	gene expression	Selenow	0.05	0.04	6.3e-06	0.06	0.06	0.06	0.05	3.0e-06	6.0e-06	7.2e-06	1.2e-05
5	Adipose	mRNA stability	Selenow	0.03	0.02	4.0e-04	0.03	0.03	0.02	0.03	4.5e-04	7.0e-04	1.6e-03	6.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.4	0.2	-0.4	-0.5	0.6	-0.6
Area under the delay curve	0.4	0.4	1.1	-1.1	-0.6	-0.5	0.5	-0.2
BMI with tail	0.8	2.9	3.8	0.8	1.8	1.9	-1.8	1.9
BMI without tail	1.8	5.5	6.4	1.8	2.5	2.5	-2.4	2.4
Body weight	2.3	10.2	11.7	3.4	3.3	3.2	-3.2	2.9
Weight adjusted by age	0.8	1.3	2.1	1.5	1.1	1.0	-0.9	1.1
Bone surface	0.6	1.1	3.9	2.0	0.7	0.5	-1.0	0.2
Bone volume	0.3	0.6	2.6	1.6	0.4	0.1	-0.2	-0.2
Breakpoint value in progressive ratio session	1.9	2.2	4.9	-2.2	-1.4	-1.3	1.3	-0.9
Number of licking bursts	1.5	2.4	2.9	1.2	1.6	1.6	-1.6	1.7
Context. condit. distance diff. score	0.0	0.0	0.1	0.2	0.1	0.1	-0.0	0.1
Locomotion velocity, session 1	0.6	0.7	1.0	-0.6	-0.9	-0.9	0.6	-1.0
Locomotion distance, session 1	0.2	0.2	0.8	0.9	-0.2	-0.2	0.1	-0.4
Locomotion velocity, session 2	1.4	1.6	2.9	1.2	1.1	1.1	-1.7	1.1
Locomotion distance, session 2	1.4	2.0	3.8	2.0	1.2	1.2	-1.6	0.9
Locomotion velocity, session 3	0.1	0.1	0.1	0.3	0.3	0.3	-0.2	0.3
Locomotion distance, session 3	0.2	0.2	0.3	0.2	-0.4	-0.4	0.5	-0.5
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.3	0.3	0.4	-0.1	0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.6	0.1	0.1	0.2	0.3
Locomotion velocity, session 7	1.2	1.3	1.8	-0.6	-1.2	-1.2	1.2	-1.3
Locomotion distance, session 7	0.0	0.1	0.1	0.0	-0.3	-0.3	0.2	-0.4
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	0.6	0.6	0.6	-0.6	0.8
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.7	0.6	0.6	-0.5	0.8
Locomotion velocity, session 8	0.1	0.2	0.5	0.0	-0.3	-0.3	0.7	-0.4
Locomotion distance, session 8	0.3	0.4	1.1	1.0	0.5	0.5	-0.6	0.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.2	0.1	-0.2	0.1
Degree of sensitization stereotypy	1.0	1.1	1.4	1.2	0.9	1.0	-1.0	1.1
Conditioned locomotion	0.1	0.1	0.1	0.1	0.3	0.3	-0.3	0.2
Cocaine response after cond. corrected	0.1	0.1	0.6	-0.7	0.1	0.2	-0.1	0.3
Cocaine response after cond. not corrected	0.4	0.5	0.6	0.4	0.7	0.7	-0.7	0.8
Cocaine response before conditioning	3.0	3.6	7.8	2.8	1.7	1.6	-1.6	1.4
Saline control response	1.2	1.6	3.3	1.8	1.2	1.1	-1.0	0.9
Bone: connectivity density	0.0	0.0	0.0	0.2	-0.1	-0.2	0.2	-0.2
Bone: cortical apparent density	0.4	0.5	1.2	-1.1	-0.6	-0.5	0.7	-0.3
Bone: cortical area	1.2	1.8	3.5	1.9	1.2	1.1	-1.4	0.9
Bone: cortical porosity	0.1	0.1	0.5	0.1	0.1	0.1	-0.7	0.1
Bone: cortical porosity	0.5	0.6	1.4	0.5	0.6	0.6	-1.2	0.6
Bone: cortical thickness	0.0	0.0	0.1	0.1	0.2	0.2	-0.2	0.1
Bone: cortical thickness	0.3	0.3	0.4	0.7	0.6	0.5	-0.6	0.4
Bone: cortical tissue density	0.5	0.6	1.4	-1.2	-0.7	-0.6	0.8	-0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.2	0.4	0.8	0.9	-0.9	1.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.5	0.3	0.9	1.1	-0.9	1.2
Condit. Reinf. active responses	0.3	0.4	0.6	0.5	0.6	0.6	-0.7	0.8
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.3	-0.6	-0.6	0.5	-0.8
Incentive salience index mean	0.6	0.7	1.0	0.7	0.8	0.9	-1.0	0.9
Condit. Reinf. lever presses	0.3	0.4	0.9	0.7	0.6	0.6	-0.9	0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	1.3	1.1	0.1	-0.0	-0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.2	1.1	0.2	0.0	-0.4	-0.3
Condit. Reinf. active responses	0.2	0.3	1.4	1.2	-0.0	-0.1	-0.1	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.4
Condit. Reinf. lever presses	0.6	0.8	1.6	1.3	0.8	0.8	-0.8	0.7
Condit. Reinf. lever reinforcers received	0.3	0.5	2.2	1.5	0.1	-0.0	-0.2	-0.3
Conditioned reinforcement - actives	1.4	2.4	3.1	1.0	1.6	1.6	-1.6	1.8
Conditioned reinforcement - inactives	0.4	0.6	1.0	0.9	0.8	0.7	-0.6	1.0
Conditioned locomotion	0.6	0.7	1.2	0.3	0.9	0.9	-0.9	1.1
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.3	-0.1	0.0	0.2	0.5
Patch foraging indifference point AUC	3.2	4.6	5.7	1.7	2.1	2.2	-2.4	2.3
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.1	-0.5	-0.5	0.7	-0.7
Delay disc. indifference point, 16s delay	0.5	0.5	2.0	-1.4	-0.6	-0.5	0.4	0.0
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	-1.0	-0.7	-0.7	0.8	-0.6
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	-0.5	0.3	0.3	-0.2	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	0.4
Delay disc. indifference point, 8s delay	0.8	0.9	1.9	-1.4	-1.0	-0.9	0.8	-0.6
Indifference point function ln k	1.9	3.4	5.6	-0.5	-1.8	-2.0	2.4	-1.9
Indifference point function log k	1.9	3.4	5.6	-0.5	-1.8	-2.0	2.4	-1.9
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	-0.1	0.1	0.2	0.1	0.5
Patch foraging total patch changes 12 sec	1.4	1.8	2.6	0.9	1.3	1.4	-1.5	1.6
Patch foraging total patch changes 18 sec	1.0	1.5	1.8	1.0	1.2	1.3	-1.2	1.3
Patch foraging total patch changes 24 sec	1.2	2.0	2.3	1.3	1.4	1.5	-1.4	1.5
Patch foraging total patch changes 6 sec	0.9	1.3	2.4	0.3	1.1	1.3	-1.2	1.6
Patch foraging time to switch 0 sec	1.5	3.1	7.2	-2.7	-1.6	-1.4	1.3	-1.5
Patch foraging water rate 0 sec	1.2	2.6	4.6	2.1	1.6	1.5	-1.2	1.5
Patch foraging water rate 12 sec	0.1	0.2	0.6	0.7	-0.1	-0.2	0.4	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.8	0.2	-0.1	-0.3	0.9	-0.3
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.2	-0.3	-0.4	0.7	-0.4
Patch foraging water rate 6 sec	2.4	3.5	8.3	2.9	1.8	1.6	-1.4	1.3
Seeking ratio, delayed vs. immediate footshock	1.9	2.3	3.5	-0.8	-1.5	-1.6	1.9	-1.6
Distance traveled before self-admin	0.2	0.2	1.1	1.0	0.2	0.1	-0.0	0.2
Distance traveled after self-admin	0.4	0.5	0.7	-0.3	-0.8	-0.9	0.8	-0.6
Extensor digitorum longus weight	1.7	6.6	8.9	3.0	2.9	2.6	-2.0	2.2
Bone: elastic displacement	2.2	2.5	3.1	-1.8	-1.5	-1.5	1.7	-1.5
Bone: elastic work	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.5	-0.5
Bone: endosteal estimation	0.3	0.6	2.5	1.6	0.3	0.2	-0.5	-0.0
Bone: endosteal perimeter	0.1	0.3	1.1	1.1	0.3	0.2	-0.5	0.2
Epididymis fat weight	0.4	1.4	1.7	-1.3	-1.2	-1.1	1.0	-1.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.0	-0.3	-0.3	0.2	-0.7
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	0.5	0.4	-0.2	0.5
Diff in mean of infusions in LGA sessions	0.8	1.0	1.3	-1.0	-1.0	-1.0	0.9	-1.1
Delay discount exponential model param	0.2	0.3	0.8	0.9	0.5	0.4	-0.4	0.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.1	-0.1	-0.1	0.3	-0.1
Active lever presses in extinction session 6	2.2	2.2	3.5	0.8	1.4	1.5	-1.7	1.9
Bone: final force	1.2	1.9	4.7	2.2	1.3	1.1	-1.0	0.8
Bone: final moment	1.3	2.1	6.0	2.4	1.4	1.2	-0.9	0.8
Food consumed during 24 hour testing period	2.9	3.9	4.8	-1.7	-2.0	-2.0	2.2	-1.9
Glucose	2.2	3.5	5.5	-2.3	-1.8	-1.7	1.9	-1.5
Heart weight	0.5	0.8	1.1	0.7	0.7	0.8	-1.1	1.1
Delay discount hyperbolic model param	0.2	0.2	0.7	0.9	0.4	0.3	-0.3	0.0
Intermittent access intake day 1-15 change	0.1	0.2	0.3	0.4	0.4	0.5	-0.6	-0.2
Intermittent access intake escalation	0.2	0.4	0.7	0.6	0.7	0.7	-0.8	0.1
Intermittent access intake escalation 2	0.0	0.0	0.2	0.1	-0.1	-0.1	0.0	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.8	-0.0	0.5	0.5	-0.5	0.9
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.1	1.0	1.0	0.9	-0.9	0.8
Intermitt. access escalation Index	0.1	0.1	0.4	-0.6	0.0	0.1	-0.5	-0.1
Intermittent access day 1 total infusions	0.5	0.8	1.1	0.7	1.0	1.0	-0.9	0.9
Intermittent access day 15 total infusions	0.2	0.4	0.8	-0.0	0.6	0.7	-0.9	0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	-0.0	0.4	0.5	-0.5	0.1
Intermittent access total infusions	0.6	0.8	1.0	0.6	1.0	1.0	-1.0	0.8
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.2	-0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.9	-0.3	-0.3	-0.3	0.2	-0.9
Intermittent access total locomotion	0.0	0.1	0.1	0.3	0.2	0.2	-0.2	-0.2
Intermittent access standard deviation	0.1	0.2	0.8	-0.9	-0.3	-0.2	-0.0	-0.5
Left kidney weight	5.3	24.4	39.1	6.3	4.9	4.7	-4.2	4.3
Right kidney weight	4.2	19.1	29.8	5.5	4.4	4.2	-3.7	3.8
Cocaine induced anxiety	0.2	0.3	0.6	-0.1	-0.5	-0.6	0.7	-0.5
Post-drug Anxiety	0.2	0.2	0.3	-0.2	-0.5	-0.5	0.6	-0.5
Baseline Anxiety	0.8	0.9	1.1	-1.1	-1.0	-1.0	0.8	-0.9
Tail length	1.7	6.6	11.5	3.4	2.6	2.4	-2.1	2.1
Length with tail	1.0	4.5	9.2	3.0	2.1	1.9	-1.8	1.5
Length without tail	0.5	1.6	3.5	1.9	1.2	1.1	-1.2	0.7
Times rat made contact with spout	0.7	0.8	1.1	-1.1	-0.8	-0.8	1.1	-0.7
Lifetime Intake	0.9	1.1	1.5	0.7	1.1	1.2	-1.1	0.9
Liver weight, left	5.5	9.2	10.5	3.2	3.1	3.0	-3.1	2.7
Liver weight, right	1.9	3.3	3.8	1.6	1.8	1.9	-1.8	2.0
Locomotor activity	1.4	2.1	3.0	1.0	1.6	1.6	-1.2	1.7
Locomotor testing distance	1.0	1.8	2.5	1.0	1.5	1.5	-1.1	1.6
Locomotor testing rearing	4.3	8.6	9.4	2.8	3.1	3.0	-2.8	2.9
Locomotion in novel chamber	2.7	3.4	4.1	-2.0	-1.9	-1.9	2.0	-1.5
Locomotion in novel chamber post-restriction	0.6	1.0	1.2	-1.1	-1.0	-0.9	1.0	-1.0
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.0	-0.1	-0.1	0.1	-0.3
Change in fecal boli incidents, locomotor task	0.7	0.7	1.5	-1.2	-0.8	-0.7	0.5	-0.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.6	-0.2	-0.1	0.1	-0.4
Bouts of movement, locomotor time 1	0.9	1.1	1.6	-0.5	-1.1	-1.1	1.1	-1.2
Total resting periods, locomotor time 1	2.2	2.4	2.9	-1.2	-1.6	-1.7	1.5	-1.7
Rest time, locomotor task time 1	0.4	0.5	0.9	-0.0	-0.7	-0.8	0.8	-1.0
Distance moved, locomotor task time 1	0.7	1.1	1.7	0.4	1.0	1.1	-1.1	1.3
Vertical activity count, locomotor time 1	0.1	0.3	0.5	-0.2	0.5	0.5	-0.5	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.2	-0.2	0.1	0.1	-0.4	-0.1
Bouts of movement, locomotor time 2	1.5	2.3	2.6	-1.3	-1.6	-1.6	1.6	-1.5
Total resting periods, locomotor time 2	1.7	3.0	3.5	-1.4	-1.8	-1.8	1.9	-1.8
Rest time, locomotor task time 2	1.6	2.1	2.7	-0.9	-1.4	-1.5	1.6	-1.6
Distance moved, locomotor task time 2	2.2	2.6	3.0	1.5	1.6	1.5	-1.7	1.6
Vertical activity count, locomotor time 2	0.9	1.2	1.4	1.0	1.1	1.1	-1.2	1.1
Light reinforcement 1	0.4	1.0	1.2	1.0	1.0	0.9	-1.0	1.1
Light reinforcement 2	0.9	1.4	2.0	0.7	1.1	1.2	-1.4	1.4
Bone: marrow area	0.3	0.7	2.8	1.7	0.4	0.3	-0.6	0.1
Bone: maximum diameter	3.2	5.9	7.6	2.8	2.3	2.3	-2.6	2.2
Bone: maximum force	0.7	1.2	3.6	1.9	0.9	0.8	-0.8	0.4
Bone: maximum moment	0.7	1.3	4.4	2.1	0.9	0.8	-0.7	0.4
Mean time between licks in bursts	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1	0.3
Mean num. licks in bursts	2.9	4.6	5.4	-1.8	-2.1	-2.2	2.3	-2.2
Cd content in liver	0.5	0.6	1.0	-0.2	-0.7	-0.8	0.9	-1.0
Co content in liver	0.6	0.7	0.8	-0.6	-0.8	-0.9	0.9	-0.8
Cu content in liver	0.9	1.1	2.2	1.5	1.1	0.9	-0.8	0.8
Fe content in liver	3.0	3.6	3.7	1.9	1.9	1.9	-1.9	1.9
K content in liver	1.1	1.1	1.9	1.4	1.1	1.0	-0.9	0.8
Mg content in liver	1.9	2.0	2.2	1.3	1.4	1.4	-1.4	1.5
Mn content in liver	0.6	0.7	0.8	0.7	0.9	0.9	-0.9	0.8
Na content in liver	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	0.1
Rb content in liver	0.6	0.7	2.2	1.5	0.7	0.6	-0.4	0.3
Se content in liver	7.9	9.3	10.9	2.2	3.2	3.2	-3.3	3.3
Sr content in liver	0.5	0.4	1.9	-1.4	-0.4	-0.3	0.1	0.1
Zn content in liver	2.3	2.6	3.2	1.0	1.7	1.7	-1.7	1.8
Bone: minimum diameter	0.8	1.4	4.9	2.2	0.9	0.6	-1.0	0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.7	0.8	-0.1	-0.3	-0.1	-0.5
Time in novel zone, hab. session 1	1.1	1.1	2.1	0.4	1.1	1.2	-0.8	1.4
Total zone transitions, hab. session 1	0.2	0.2	1.0	1.0	0.1	0.0	-0.1	-0.1
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.1	-0.6	-0.7	0.8	-0.7
Locomotion velocity, hab. session 1	0.9	1.3	1.5	-0.7	-1.1	-1.2	1.2	-1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.0	-0.5
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.4	0.5	0.5	-0.4	0.7
Total zone transitions, hab. session 2	0.6	0.7	2.4	1.6	0.6	0.6	-0.7	0.3
Total locomotion distance, hab. session 2	0.4	0.6	0.8	-0.3	-0.8	-0.8	0.9	-0.8
Locomotion velocity, hab. session 2	0.3	0.3	0.5	-0.2	-0.6	-0.6	0.7	-0.6
Novel to familiar place preference ratio	0.8	0.8	1.1	1.1	1.0	0.9	-0.3	1.0
Novelty place preference	0.7	0.7	1.2	1.1	0.9	0.8	-0.3	0.9
Time in novel zone, NPP test	0.7	0.8	1.3	1.1	1.0	0.8	-0.3	0.9
Total zone transitions, NPP test	0.2	0.3	0.5	0.7	0.4	0.5	-0.6	0.3
Total locomotion distance, NPP test	0.0	0.0	0.1	0.4	0.1	0.2	-0.1	0.2
Locomotion velocity, NPP test	0.0	0.1	0.2	0.5	0.2	0.2	-0.1	0.2
Intraocular pressure	0.1	0.2	0.3	-0.2	-0.5	-0.5	0.3	-0.6
Delta distance traveled before/after self-admin	0.6	0.6	1.5	-1.2	-0.7	-0.6	0.6	-0.6
Delta ambulatory time before/after self-admin	0.4	0.5	1.5	-1.2	-0.6	-0.6	0.5	-0.5
Parametrial fat weight	0.5	1.1	3.1	-1.8	-0.9	-0.8	1.0	-0.4
Pavlov. Cond. lever latency	0.8	1.0	1.2	-0.9	-1.1	-1.1	1.0	-1.0
Pavlov. Cond. magazine entry latency	0.8	1.0	1.3	0.5	1.1	1.1	-0.9	1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.1	-0.1
Pavlov. Cond. index score	1.1	1.4	1.7	0.8	1.3	1.3	-1.2	1.2
Pavlov. Cond. latency score	0.5	0.7	0.9	0.5	1.0	0.9	-0.8	0.8
Pavlov. Cond. lever contacts	0.6	0.7	0.9	0.7	0.9	0.9	-0.8	0.8
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	-0.7	-1.0	-1.0	1.1	-0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.9	-0.1	-0.6	-0.7	0.9	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.8	0.9	1.3	1.3	-1.2	1.2
Pavlov. Cond. response bias	2.1	2.6	3.0	1.3	1.7	1.7	-1.7	1.5
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.4	-0.3	-0.4	0.5	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	0.1	0.2	-0.2	0.3
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	0.2	-0.6	-0.6	0.5	-0.6
Pavlov. Cond. index score	0.0	0.1	0.1	0.4	0.1	0.2	-0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.0	0.0
Pavlov. Cond. lever contacts	0.3	0.5	0.6	0.8	0.6	0.7	-0.7	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.5	0.3	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.8	0.9	0.2	0.1	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	0.3	0.4	-0.4	0.4
Pavlov. Cond. response bias	0.2	0.3	0.8	0.9	0.3	0.4	-0.5	0.4
Time in closed arm before self-admin	0.2	0.2	0.4	0.3	0.4	0.4	-0.6	0.6
Time in closed arm after self-admin	0.3	0.3	0.6	-0.4	-0.5	-0.5	0.3	-0.8
Time in open arm before self-admin	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.6	-0.1
Time in open arm after self-admin	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.4	0.1
Bone: periosteal estimation	0.8	1.6	4.9	2.2	1.0	0.8	-1.2	0.5
Bone: periosteal perimeter	0.7	1.2	3.4	1.8	0.8	0.7	-1.0	0.5
Bone: post-yield work	0.1	0.2	0.5	0.7	-0.2	-0.3	-0.0	-0.5
Progressive ratio test 1 active lever presses	0.7	0.9	1.3	1.1	1.0	1.0	-0.8	0.8
Progressive ratio test 1 breakpoint	0.6	0.7	1.0	1.0	0.9	0.8	-0.7	0.7
Progressive ratio test 1 inactive lever presses	1.4	2.0	2.7	1.7	1.5	1.4	-1.2	1.2
Progressive ratio test 2 active lever presses	1.4	1.7	2.2	0.7	1.4	1.5	-1.4	1.3
Progressive ratio test 2 breakpoint	1.6	1.9	2.4	0.8	1.5	1.6	-1.5	1.3
Progressive ratio test 2 inactive lever presses	1.0	1.6	2.3	1.5	1.3	1.3	-1.1	0.9
Incentive Sensitization - Responses	0.7	1.0	1.4	0.5	1.1	1.2	-1.1	1.0
Incentive Sensitization - Breakpoint	0.8	1.1	1.4	0.5	1.1	1.2	-1.1	1.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	-0.9	-0.6	-0.6	0.4	-0.3
Progressive ratio	0.1	0.2	0.5	0.1	-0.3	-0.3	0.4	-0.7
Food seeking constrained by brief footshock	2.5	3.1	4.4	-0.6	-1.7	-1.9	2.0	-2.1
Seeking ratio, punishment vs. effort	0.4	0.6	0.8	-0.4	-0.8	-0.9	0.9	-0.9
Retroperitoneal fat weight	0.5	2.2	8.6	-2.9	-1.0	-0.8	0.8	-0.4
Reaction time number correct	1.2	2.3	2.6	1.2	1.6	1.6	-1.5	1.6
Reaction time mean minus median	0.4	1.0	1.4	-0.9	-1.1	-1.0	0.7	-1.2
Reaction time mean minus median AUC	0.1	0.1	0.4	-0.2	-0.3	-0.3	0.1	-0.7
Reaction time num false alarms	4.6	6.5	7.5	2.1	2.7	2.7	-2.5	2.7
Reaction time num false alarms AUC	3.2	5.0	6.0	1.8	2.4	2.4	-2.1	2.4
Reaction time trials correct on left	1.2	2.3	2.6	1.2	1.6	1.6	-1.5	1.6
Reaction time trials on left	1.2	2.3	2.7	1.2	1.6	1.6	-1.6	1.6
Reaction time mean	1.2	1.9	2.3	-1.2	-1.5	-1.5	1.3	-1.3
Reaction time mean AUC	1.0	1.6	1.9	-1.3	-1.3	-1.4	1.2	-1.2
Median of all reaction times	0.9	1.3	1.6	-1.1	-1.2	-1.3	1.1	-1.0
Reaction time omissions	0.0	0.1	0.2	-0.1	0.1	0.1	-0.2	0.5
Reaction time false alarm rate	0.6	0.8	1.2	0.6	1.0	1.0	-0.7	1.1
Reaction time premature initiation rate	2.0	2.8	3.2	-1.8	-1.8	-1.7	1.6	-1.5
Reaction time premature initiations	0.4	0.8	1.1	-1.0	-0.9	-0.9	0.9	-0.7
Std. dev. reaction times	0.6	1.2	1.3	-1.0	-1.1	-1.1	1.0	-1.1
Reaction time trials completed	1.2	2.3	2.7	1.2	1.6	1.6	-1.6	1.6
Reaction time trials AUC	1.5	2.9	3.6	1.3	1.8	1.8	-1.7	1.9
Run reversals in cocaine runway, females	1.8	1.8	2.6	-1.6	-1.4	-1.4	1.1	-1.1
Run reversals in cocaine runway, males	0.6	0.6	0.7	0.8	0.8	0.8	-0.7	0.6
Latency to leave start box in cocaine runway	0.5	0.6	1.0	-0.7	-0.8	-0.8	0.5	-1.0
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	-0.7	-0.6	-0.5	0.3	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.5	0.0	-0.0	-0.0	-0.3
Std. dev. time between licks in bursts	0.6	0.8	1.0	0.8	0.9	0.9	-0.8	1.0
Total sessions with >9 infusions	1.4	1.6	2.3	1.5	1.4	1.4	-1.1	1.0
Short access day 1 total inactive lever presses	1.4	1.8	2.5	1.3	1.4	1.5	-1.6	0.8
Short access day 10 total inactive lever presses	0.4	0.9	1.4	-0.8	-1.0	-1.1	1.2	-0.7
Short access day 1 total infusions	0.7	0.9	1.2	0.7	1.0	1.1	-1.0	0.8
Short access day 10 total infusions	2.6	3.3	4.0	1.3	1.9	2.0	-1.9	1.9
Short access total infusions	1.3	1.6	2.1	0.9	1.4	1.5	-1.4	1.3
Short access day 1 locomotion	1.9	2.4	2.8	1.5	1.7	1.6	-1.4	1.5
Short access day 10 total locomotion	0.4	0.7	1.1	-0.3	-0.7	-0.8	1.0	-1.0
Short access total locomotion	0.1	0.1	0.3	0.5	0.3	0.3	-0.0	0.1
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Compulsive drug intake	0.1	0.1	0.3	0.6	0.3	0.3	-0.2	0.4
One hour access (shock baseline)	0.3	0.5	1.0	0.1	0.7	0.8	-1.0	0.5
Social response proportion	1.1	1.3	1.8	0.9	1.2	1.2	-1.0	1.3
Social responses	2.4	3.1	4.3	2.1	1.9	1.8	-1.3	1.7
Social time	0.2	0.3	0.6	0.8	-0.2	-0.3	0.4	-0.6
Soleus weight	0.5	1.3	1.7	1.2	1.3	1.2	-1.0	1.1
Bone: stiffness	1.7	2.7	5.6	2.4	1.6	1.5	-1.3	1.2
Tibialis anterior weight	2.8	9.4	11.0	2.5	3.3	3.3	-2.8	3.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.0	0.1	0.0	0.1	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.2	-0.3
Time to tail flick, test, before self-admin	1.8	1.9	2.6	-0.9	-1.4	-1.4	1.6	-1.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1	-0.2
Delta time to tail flick, test, before/after SA	0.7	0.7	1.1	0.4	0.8	0.8	-1.0	0.9
Tibia length	1.9	5.2	10.6	3.3	2.2	2.1	-1.8	1.7
Ambulatory time before self-admin	0.1	0.2	1.0	1.0	0.0	-0.1	0.1	0.0
Ambulatory time after self-admin	0.6	0.7	1.0	-0.3	-0.9	-0.9	1.0	-0.8
Bone: tissue strength	0.2	0.2	0.2	-0.2	-0.5	-0.4	0.5	-0.5
Total heroin consumption	0.1	0.2	0.4	0.2	0.4	0.4	-0.3	0.6
Bone: trabecular number	0.1	0.2	0.3	-0.1	-0.4	-0.5	0.5	-0.5
Bone: trabecular spacing	0.0	0.0	0.1	-0.0	0.2	0.2	-0.0	0.2
Bone: trabecular thickness	0.5	0.6	0.8	0.9	0.8	0.7	-0.9	0.6
Bone: trabecular tissue density	0.2	0.3	0.7	-0.8	0.1	0.3	-0.3	0.6
Water consumed over 24 hours	0.7	0.9	1.3	-0.4	-0.9	-1.0	1.2	-1.0
Number of responses in last shaping day	1.8	1.9	3.1	0.8	1.4	1.5	-1.8	1.4