Hub : Genes

Selenow

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Selenow	0.64	0.12	0.0e+00	0.23	0.24	0.23	0.23	8.7e-26	8.5e-27	1.1e-25	1.0e-25
2	Adipose	gene expression	Selenow	0.29	0.17	3.9e-16	0.14	0.13	0.13	0.13	8.4e-15	1.9e-14	1.6e-14	1.6e-14
3	NAcc	gene expression	Selenow	0.02	0.02	3.2e-03	0	0	0	0	8.9e-02	1.4e-01	3.5e-01	2.7e-01
4	Brain	gene expression	Selenow	0.07	0.05	2.2e-07	0.09	0.08	0.06	0.08	2.4e-08	1.3e-07	2.6e-06	4.8e-08
5	Adipose	mRNA stability	Selenow	0.03	0.02	3.3e-04	0.03	0.03	0.02	0.03	4.3e-04	6.5e-04	2.0e-03	8.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.3	-0.3	0.8	0.9	-1.1	0.9
Area under the delay curve	0.4	0.4	1.3	-1.2	0.6	0.3	-0.2	0.2
BMI with tail	1.0	3.4	4.3	0.6	-2.1	-2.0	2.0	-2.0
BMI without tail	2.3	4.7	5.7	1.1	-2.4	-2.4	2.3	-2.3
Body weight	1.5	6.1	7.8	2.3	-2.8	-2.6	2.1	-2.4
Weight adjusted by age	1.0	1.1	2.1	1.4	-0.7	-1.1	0.8	-1.1
Bone surface	0.3	0.5	2.3	1.5	0.0	0.0	-0.2	-0.0
Bone volume	0.3	0.4	1.2	1.1	0.3	0.4	-0.7	0.5
Breakpoint value in progressive ratio session	2.8	3.1	8.0	-2.8	1.5	1.3	-1.4	1.3
Number of licking bursts	2.3	2.7	3.1	1.4	-1.7	-1.7	1.8	-1.7
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.1	-0.2
Locomotion velocity, session 1	0.7	0.7	1.1	-0.3	0.9	1.0	-1.0	0.8
Locomotion distance, session 1	0.3	0.3	1.0	1.0	0.4	0.5	-0.4	0.4
Locomotion velocity, session 2	0.9	1.1	1.5	1.2	-0.9	-1.0	1.0	-1.1
Locomotion distance, session 2	1.0	1.4	3.7	1.9	-0.9	-0.8	0.9	-0.9
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.3
Locomotion distance, session 3	0.4	0.4	0.9	0.5	0.4	0.6	-0.9	0.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.2	-0.4	-0.5	0.6	-0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.5	-0.1	-0.2	0.4	-0.1
Locomotion velocity, session 7	1.3	1.4	1.7	-0.9	1.2	1.3	-1.3	1.3
Locomotion distance, session 7	0.1	0.2	0.3	-0.1	0.2	0.4	-0.5	0.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.6	-0.3	-0.4	0.1	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.7	-0.5	-0.6	0.4	-0.7
Locomotion velocity, session 8	0.1	0.2	0.4	-0.0	0.3	0.4	-0.6	0.4
Locomotion distance, session 8	0.2	0.3	1.1	1.0	-0.4	-0.4	-0.1	-0.4
Degree of sensitization distance	0.1	0.1	0.2	-0.4	-0.1	-0.1	0.4	-0.1
Degree of sensitization stereotypy	1.0	1.1	1.8	1.4	-0.9	-1.0	0.7	-1.1
Conditioned locomotion	0.1	0.1	0.2	0.3	-0.4	-0.3	0.4	-0.3
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.6	-0.2	-0.4	0.6	-0.4
Cocaine response after cond. not corrected	0.6	0.7	1.1	0.6	-0.7	-0.8	1.0	-0.8
Cocaine response before conditioning	2.6	3.1	8.6	2.9	-1.4	-1.3	1.3	-1.3
Saline control response	0.8	1.1	2.6	1.6	-0.8	-0.8	0.8	-0.8
Bone: connectivity density	0.1	0.2	0.3	-0.1	0.4	0.4	-0.5	0.4
Bone: cortical apparent density	0.1	0.1	0.5	-0.7	0.1	0.1	-0.0	0.0
Bone: cortical area	0.6	0.8	1.9	1.4	-0.9	-0.8	0.6	-0.8
Bone: cortical porosity	0.0	0.1	0.2	-0.5	-0.1	0.0	-0.1	0.1
Bone: cortical porosity	0.2	0.2	0.4	0.1	-0.6	-0.5	0.4	-0.5
Bone: cortical thickness	0.0	0.1	0.2	-0.5	-0.2	-0.0	-0.2	0.0
Bone: cortical thickness	0.1	0.2	0.4	0.7	-0.4	-0.3	0.2	-0.3
Bone: cortical tissue density	0.1	0.1	0.6	-0.7	0.1	0.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.9	1.0	1.3	0.4	-1.0	-1.0	1.2	-1.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.5	0.2	-1.1	-1.2	1.2	-1.2
Condit. Reinf. active responses	0.5	0.6	0.9	0.6	-0.7	-0.7	0.9	-0.9
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.4	0.6	0.6	-0.4	0.4
Incentive salience index mean	0.7	0.9	1.1	0.8	-0.9	-0.9	1.0	-1.0
Condit. Reinf. lever presses	0.3	0.4	0.6	0.8	-0.5	-0.5	0.6	-0.6
Condit. Reinf. active minus inactive responses	0.3	0.3	1.3	1.1	0.3	0.3	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	1.1	0.2	0.1	-0.1	0.1
Condit. Reinf. active responses	0.3	0.4	1.3	1.2	0.4	0.4	-0.4	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.0	0.5	0.5	-0.6	0.4
Condit. Reinf. lever presses	0.6	0.8	1.2	1.1	-0.9	-0.9	0.8	-0.9
Condit. Reinf. lever reinforcers received	0.3	0.5	2.2	1.5	0.3	0.2	-0.3	0.2
Conditioned reinforcement - actives	1.5	1.5	2.2	0.4	-1.4	-1.5	1.3	-1.2
Conditioned reinforcement - inactives	1.7	1.9	2.4	1.5	-0.9	-1.4	1.5	-1.5
Conditioned locomotion	1.2	1.4	2.4	0.4	-1.2	-1.3	1.6	-1.1
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.3	-0.1	-0.3	0.2	-0.5
Patch foraging indifference point AUC	3.2	3.7	4.3	1.6	-2.1	-2.0	1.8	-2.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.0	0.6	0.5	-0.4	0.5
Delay disc. indifference point, 16s delay	0.4	0.4	1.9	-1.4	0.5	0.1	0.2	-0.0
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	-0.9	0.7	0.6	-0.6	0.6
Delay disc. indifference point, 24s delay	0.5	0.4	0.9	-0.4	-0.3	-0.7	0.9	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.4	-0.3	-0.5	0.4	-0.5
Delay disc. indifference point, 8s delay	0.7	0.7	1.7	-1.3	1.0	0.6	-0.5	0.6
Indifference point function ln k	2.5	3.5	5.1	-0.5	2.3	2.1	-1.9	2.0
Indifference point function log k	2.5	3.5	5.1	-0.5	2.3	2.1	-1.9	2.0
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.2	-0.5
Patch foraging total patch changes 12 sec	1.7	2.1	2.8	0.9	-1.5	-1.7	1.4	-1.7
Patch foraging total patch changes 18 sec	1.4	1.8	2.5	1.1	-1.6	-1.4	1.2	-1.4
Patch foraging total patch changes 24 sec	1.8	2.1	2.8	1.4	-1.7	-1.6	1.2	-1.5
Patch foraging total patch changes 6 sec	1.2	1.8	2.6	0.5	-1.5	-1.6	1.3	-1.6
Patch foraging time to switch 0 sec	2.1	3.3	8.5	-2.9	1.2	1.4	-1.4	1.5
Patch foraging water rate 0 sec	1.8	2.9	5.2	2.3	-1.4	-1.6	1.5	-1.6
Patch foraging water rate 12 sec	0.1	0.2	0.8	0.9	0.3	0.3	-0.2	0.2
Patch foraging water rate 18 sec	0.0	0.1	0.1	0.4	0.2	0.2	-0.2	0.2
Patch foraging water rate 24 sec	0.2	0.2	0.4	0.3	0.6	0.5	-0.4	0.4
Patch foraging water rate 6 sec	2.3	3.3	9.3	3.0	-1.4	-1.4	1.4	-1.3
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	3.5	-0.8	1.5	1.4	-1.9	1.5
Distance traveled before self-admin	0.2	0.2	1.0	1.0	-0.1	-0.0	-0.1	-0.2
Distance traveled after self-admin	0.7	0.8	1.6	-0.0	1.0	0.7	-1.3	0.9
Extensor digitorum longus weight	1.4	5.6	7.1	2.7	-2.6	-2.4	1.9	-2.2
Bone: elastic displacement	2.8	3.2	4.1	-2.0	1.8	1.8	-1.6	1.8
Bone: elastic work	0.2	0.3	0.4	-0.2	0.7	0.5	-0.5	0.5
Bone: endosteal estimation	0.3	0.6	2.9	1.7	0.0	-0.1	-0.0	-0.1
Bone: endosteal perimeter	0.2	0.4	1.7	1.3	-0.0	-0.2	0.1	-0.2
Epididymis fat weight	0.8	1.8	3.7	-1.9	1.0	1.1	-1.1	1.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.5	-0.3	-0.6	-0.4	-0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.4	-0.3	-0.1	0.7	-0.2
Diff in mean of infusions in LGA sessions	1.9	2.1	3.2	-1.3	1.1	1.4	-1.8	1.6
Delay discount exponential model param	0.2	0.3	1.0	1.0	-0.5	-0.1	0.1	-0.1
Extinction: sum of active levers before priming	0.8	0.8	0.9	-0.7	0.9	0.9	-1.0	1.0
Active lever presses in extinction session 6	1.8	1.8	2.6	0.6	-1.4	-1.6	1.2	-1.6
Bone: final force	0.8	1.2	3.5	1.9	-0.9	-0.9	0.6	-0.8
Bone: final moment	0.9	1.5	4.5	2.1	-1.0	-0.9	0.6	-0.8
Food consumed during 24 hour testing period	3.0	3.6	5.3	-1.4	1.8	1.9	-2.3	1.9
Glucose	1.7	2.6	3.9	-2.0	1.5	1.6	-1.5	1.5
Heart weight	0.6	0.9	1.9	1.0	-0.6	-0.7	1.4	-0.9
Delay discount hyperbolic model param	0.1	0.2	0.6	0.8	-0.4	-0.0	-0.0	0.0
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.5	-0.5	0.2	-0.4	0.2
Intermittent access intake escalation	0.1	0.1	0.2	0.2	-0.4	0.4	-0.5	0.4
Intermittent access intake escalation 2	0.2	0.2	0.5	0.5	-0.3	0.2	-0.7	0.2
Intermitt. access day 1 inactive lever presses	1.0	1.0	1.8	0.5	-0.5	-1.2	1.2	-1.4
Intermitt. access day 15 inactive lever presses	2.8	3.1	3.7	1.8	-1.7	-1.8	1.5	-1.9
Intermitt. access escalation Index	0.1	0.1	0.3	-0.5	-0.2	-0.0	0.4	-0.1
Intermittent access day 1 total infusions	0.9	1.1	2.2	0.9	-1.0	-0.8	1.5	-0.9
Intermittent access day 15 total infusions	0.2	0.2	0.5	0.2	-0.7	-0.2	0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.2	-0.5	-0.1	0.4	-0.0
Intermittent access total infusions	0.6	0.7	1.4	0.6	-0.9	-0.7	1.2	-0.7
Intermittent access day 1 locomotion	0.3	0.3	0.5	-0.6	0.7	0.5	0.5	0.4
Intermittent access day 15 total locomotion	0.4	0.5	0.8	-0.8	0.4	0.9	0.2	0.8
Intermittent access total locomotion	0.2	0.2	0.8	-0.1	0.2	0.2	0.9	0.2
Intermittent access standard deviation	0.9	0.9	2.4	0.5	-1.6	-1.0	0.4	-0.9
Left kidney weight	7.4	20.9	31.1	5.6	-4.5	-4.3	4.1	-4.2
Right kidney weight	5.0	13.9	17.3	4.2	-3.6	-3.8	3.5	-3.6
Cocaine induced anxiety	1.6	1.8	3.4	-0.4	1.8	1.6	-1.1	1.3
Post-drug Anxiety	0.1	0.1	0.3	-0.1	0.5	0.6	0.0	0.2
Baseline Anxiety	0.2	0.2	0.4	-0.3	-0.6	-0.4	0.5	-0.4
Tail length	0.4	1.3	2.5	1.6	-1.0	-1.1	0.8	-1.1
Length with tail	0.5	2.0	5.8	2.4	-1.2	-1.1	0.6	-1.0
Length without tail	0.2	0.5	1.9	1.4	-0.6	-0.4	0.1	-0.3
Times rat made contact with spout	0.5	0.6	1.0	-0.7	0.7	0.7	-1.0	0.8
Lifetime Intake	0.6	0.7	1.7	0.5	-0.8	-0.6	1.3	-0.5
Liver weight, left	11.7	18.7	21.3	3.8	-4.6	-4.5	4.3	-4.4
Liver weight, right	3.5	5.8	7.2	1.7	-2.4	-2.6	2.7	-2.6
Locomotor activity	1.6	2.6	3.2	1.2	-1.6	-1.7	1.6	-1.8
Locomotor testing distance	0.7	1.2	1.4	0.9	-1.0	-1.1	1.2	-1.2
Locomotor testing rearing	5.4	8.3	9.0	3.0	-2.8	-2.8	3.0	-2.9
Locomotion in novel chamber	3.0	3.7	5.8	-2.4	2.3	1.7	-1.3	1.7
Locomotion in novel chamber post-restriction	1.0	1.2	1.3	-1.1	1.1	1.0	-1.1	1.1
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.0	0.5	0.6	-0.5	0.6
Change in fecal boli incidents, locomotor task	0.5	0.5	1.5	-1.2	0.5	0.5	-0.3	0.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	-0.8	0.4	0.7	0.1	0.6
Bouts of movement, locomotor time 1	1.4	1.5	2.1	-0.5	1.3	1.5	-1.4	1.3
Total resting periods, locomotor time 1	2.4	2.6	3.4	-1.2	1.7	1.8	-1.6	1.7
Rest time, locomotor task time 1	0.5	0.6	1.0	0.3	0.9	1.0	-0.6	0.9
Distance moved, locomotor task time 1	0.7	0.8	1.2	0.1	-0.9	-1.1	0.8	-1.1
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.4	-0.3	-0.5	0.3	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.5	0.2
Bouts of movement, locomotor time 2	1.7	1.8	2.4	-1.2	1.6	1.5	-1.2	1.3
Total resting periods, locomotor time 2	2.3	2.5	3.4	-1.3	1.9	1.8	-1.4	1.6
Rest time, locomotor task time 2	1.9	2.1	3.1	-1.1	1.8	1.7	-1.0	1.6
Distance moved, locomotor task time 2	1.8	2.0	2.8	1.4	-1.7	-1.6	0.8	-1.5
Vertical activity count, locomotor time 2	0.8	0.9	1.2	1.0	-1.1	-1.0	0.5	-1.0
Light reinforcement 1	0.6	1.0	1.6	1.2	-0.8	-1.0	1.0	-1.0
Light reinforcement 2	1.1	1.5	2.3	0.6	-1.2	-1.4	1.5	-1.3
Bone: marrow area	0.3	0.6	3.2	1.8	-0.0	-0.1	0.0	-0.1
Bone: maximum diameter	2.5	4.6	6.5	2.5	-2.0	-2.0	1.9	-2.1
Bone: maximum force	0.5	0.8	2.7	1.7	-0.7	-0.7	0.4	-0.6
Bone: maximum moment	0.5	0.9	3.4	1.8	-0.7	-0.6	0.3	-0.6
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.3	-0.2
Mean num. licks in bursts	3.8	4.6	5.9	-1.7	2.1	2.2	-2.4	2.2
Cd content in liver	0.2	0.2	0.4	0.1	0.3	0.5	-0.6	0.6
Co content in liver	1.4	1.6	2.4	-1.0	1.2	1.3	-1.6	1.3
Cu content in liver	0.5	0.6	1.6	1.3	-0.7	-0.6	0.4	-0.4
Fe content in liver	0.2	0.3	0.4	0.6	-0.5	-0.6	0.2	-0.6
K content in liver	1.7	1.6	2.4	1.6	-1.4	-1.3	1.1	-1.0
Mg content in liver	1.7	1.7	2.0	1.0	-1.3	-1.3	1.4	-1.4
Mn content in liver	1.1	1.3	1.7	0.7	-1.3	-1.3	1.2	-1.1
Na content in liver	0.1	0.1	0.2	-0.4	-0.0	-0.1	-0.2	0.1
Rb content in liver	0.3	0.4	1.1	1.0	-0.8	-0.5	0.3	-0.4
Se content in liver	5.3	6.5	8.0	1.5	-2.7	-2.8	2.8	-2.7
Sr content in liver	0.3	0.2	0.9	-1.0	-0.2	-0.2	0.4	-0.3
Zn content in liver	1.1	1.2	1.8	0.6	-1.1	-1.1	1.4	-1.1
Bone: minimum diameter	0.6	1.1	4.7	2.2	-0.4	-0.4	0.2	-0.4
Time in familiar zone, hab. session 1	0.4	0.3	1.1	1.0	0.3	0.4	-0.3	0.5
Time in novel zone, hab. session 1	1.4	1.4	1.9	0.2	-1.3	-1.3	1.2	-1.4
Total zone transitions, hab. session 1	0.2	0.3	1.2	1.1	0.2	0.1	-0.1	0.1
Total locomotion distance, hab. session 1	0.4	0.6	1.0	0.0	0.7	0.9	-1.0	0.9
Locomotion velocity, hab. session 1	1.1	1.6	2.2	-0.6	1.3	1.4	-1.5	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.2	0.4	0.3	-0.2	0.5
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.1	-0.7	-0.5	0.4	-0.7
Total zone transitions, hab. session 2	0.6	0.8	3.0	1.7	-0.3	-0.4	0.5	-0.5
Total locomotion distance, hab. session 2	0.5	0.7	1.1	-0.2	0.7	1.0	-1.0	1.0
Locomotion velocity, hab. session 2	0.4	0.5	0.7	-0.1	0.6	0.8	-0.9	0.8
Novel to familiar place preference ratio	0.7	0.7	0.8	0.9	-0.9	-0.9	0.6	-0.9
Novelty place preference	0.5	0.6	0.9	1.0	-0.8	-0.7	0.4	-0.7
Time in novel zone, NPP test	0.6	0.6	1.0	1.0	-0.8	-0.8	0.5	-0.8
Total zone transitions, NPP test	0.2	0.3	0.7	0.8	-0.4	-0.4	0.3	-0.6
Total locomotion distance, NPP test	0.0	0.1	0.2	0.5	-0.3	-0.1	-0.0	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.4	0.6	-0.3	-0.1	-0.1	-0.1
Intraocular pressure	0.3	0.4	0.6	-0.3	0.6	0.6	-0.8	0.6
Delta distance traveled before/after self-admin	0.7	0.8	1.2	-0.9	0.8	0.6	-1.1	0.9
Delta ambulatory time before/after self-admin	0.8	0.9	1.1	-1.0	0.9	0.7	-1.0	1.0
Parametrial fat weight	0.6	1.1	5.4	-2.3	0.4	0.0	0.1	-0.0
Pavlov. Cond. lever latency	0.7	0.9	1.1	-0.8	0.9	1.0	-1.0	1.0
Pavlov. Cond. magazine entry latency	1.2	1.6	2.2	0.7	-1.2	-1.3	1.5	-1.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.0	0.0	0.1	-0.1
Pavlov. Cond. index score	1.4	1.7	2.1	0.9	-1.3	-1.4	1.5	-1.5
Pavlov. Cond. latency score	0.7	0.9	1.2	0.5	-0.9	-1.0	1.1	-1.1
Pavlov. Cond. lever contacts	1.1	1.3	1.6	0.9	-1.1	-1.2	1.3	-1.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.3	-0.8	1.0	1.1	-1.1	1.1
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	-0.3	0.7	0.8	-0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.5	1.0	-1.3	-1.5	1.6	-1.6
Pavlov. Cond. response bias	3.1	3.8	4.4	1.6	-1.9	-2.0	2.1	-2.1
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.1	0.5	0.5	-0.4	0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.3	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.1	0.6	0.6	-0.7	0.6
Pavlov. Cond. index score	0.0	0.1	0.1	0.0	-0.3	-0.3	0.2	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.4	-0.1	-0.0	0.0	-0.0
Pavlov. Cond. lever contacts	0.4	0.5	0.6	0.6	-0.7	-0.7	0.7	-0.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.7	-0.4	-0.4	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.9	1.4	0.1	0.1	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	-0.4
Pavlov. Cond. response bias	0.2	0.2	0.5	0.7	-0.4	-0.4	0.4	-0.5
Time in closed arm before self-admin	0.2	0.2	0.4	0.2	-0.7	-0.3	0.5	-0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.0	-0.2	-0.1	-0.4	-0.2
Time in open arm before self-admin	0.1	0.1	0.3	-0.1	0.6	0.2	-0.4	0.0
Time in open arm after self-admin	0.0	0.1	0.1	0.1	0.2	0.2	0.4	0.1
Bone: periosteal estimation	0.5	1.0	3.9	2.0	-0.6	-0.6	0.4	-0.6
Bone: periosteal perimeter	0.4	0.7	2.9	1.7	-0.4	-0.4	0.3	-0.4
Bone: post-yield work	0.1	0.1	0.7	0.8	0.0	0.1	-0.2	0.1
Progressive ratio test 1 active lever presses	0.3	0.3	1.0	1.0	-0.1	-0.1	0.8	-0.1
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.9	-0.1	-0.1	0.7	-0.0
Progressive ratio test 1 inactive lever presses	2.3	2.5	4.5	2.1	-1.2	-1.2	1.8	-1.4
Progressive ratio test 2 active lever presses	0.4	0.5	1.1	0.4	-0.7	-0.6	1.0	-0.5
Progressive ratio test 2 breakpoint	0.4	0.4	1.0	0.4	-0.7	-0.6	1.0	-0.5
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.6	1.2	-0.9	-0.8	0.9	-0.8
Incentive Sensitization - Responses	0.3	0.3	0.4	0.4	-0.5	-0.6	0.7	-0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.3	-0.6	-0.6	0.7	-0.4
Sum of active levers in priming session hrs 5-6	1.8	1.7	2.8	-1.7	1.3	1.2	-1.3	1.0
Progressive ratio	0.2	0.3	0.5	-0.1	0.3	0.6	-0.6	0.7
Food seeking constrained by brief footshock	3.4	4.2	5.2	-0.9	2.2	2.3	-2.3	2.3
Seeking ratio, punishment vs. effort	0.7	0.9	1.3	-0.5	1.1	1.0	-1.0	1.0
Retroperitoneal fat weight	0.6	2.1	9.4	-3.1	0.4	0.4	-0.5	0.6
Reaction time number correct	1.8	2.6	2.8	1.5	-1.6	-1.7	1.6	-1.6
Reaction time mean minus median	0.7	1.0	1.5	-0.7	0.8	1.0	-1.2	1.1
Reaction time mean minus median AUC	0.2	0.2	0.5	0.0	0.2	0.5	-0.7	0.6
Reaction time num false alarms	5.2	7.0	8.4	2.2	-2.8	-2.9	2.6	-2.7
Reaction time num false alarms AUC	4.1	5.6	6.8	1.9	-2.5	-2.6	2.4	-2.4
Reaction time trials correct on left	1.8	2.6	2.8	1.5	-1.6	-1.7	1.6	-1.6
Reaction time trials on left	1.9	2.7	3.0	1.5	-1.6	-1.7	1.7	-1.6
Reaction time mean	1.3	1.8	2.2	-1.3	1.5	1.3	-1.3	1.3
Reaction time mean AUC	1.2	1.6	2.0	-1.4	1.3	1.1	-1.2	1.2
Median of all reaction times	1.0	1.4	1.9	-1.3	1.4	1.1	-1.0	1.0
Reaction time omissions	0.4	0.5	1.0	0.1	-0.4	-1.0	0.8	-0.9
Reaction time false alarm rate	0.7	0.9	1.2	0.6	-1.1	-1.1	1.0	-1.0
Reaction time premature initiation rate	1.8	2.5	3.1	-1.8	1.7	1.5	-1.3	1.6
Reaction time premature initiations	0.4	0.5	0.9	-1.0	0.8	0.5	-0.5	0.8
Std. dev. reaction times	0.8	1.1	1.4	-0.9	1.0	1.0	-1.2	1.1
Reaction time trials completed	1.9	2.7	3.0	1.5	-1.6	-1.7	1.7	-1.6
Reaction time trials AUC	2.4	3.5	3.8	1.7	-1.8	-2.0	1.9	-1.9
Run reversals in cocaine runway, females	1.2	1.2	2.0	-1.4	1.1	1.2	-0.6	1.0
Run reversals in cocaine runway, males	0.8	0.8	1.3	1.1	-0.9	-0.8	0.7	-0.8
Latency to leave start box in cocaine runway	0.5	0.6	0.9	-0.6	0.5	0.9	-0.7	0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.5	0.3	0.5	-0.4	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.6	-0.3	-0.1	0.2	-0.1
Std. dev. time between licks in bursts	0.8	0.9	1.2	1.1	-1.0	-0.9	0.9	-0.9
Total sessions with >9 infusions	2.4	2.6	4.3	1.7	-1.3	-1.5	2.1	-1.4
Short access day 1 total inactive lever presses	1.1	1.2	2.5	1.1	-1.2	-0.8	1.6	-0.7
Short access day 10 total inactive lever presses	0.4	0.5	0.9	-0.7	1.0	0.4	-0.8	0.3
Short access day 1 total infusions	0.4	0.4	1.3	0.6	-0.3	-0.3	1.1	-0.3
Short access day 10 total infusions	2.2	2.4	3.5	1.2	-1.7	-1.5	1.9	-1.4
Short access total infusions	0.4	0.4	1.5	0.1	-0.5	-0.4	1.2	-0.4
Short access day 1 locomotion	0.4	0.5	0.8	0.5	-0.3	-0.7	0.9	-0.7
Short access day 10 total locomotion	1.0	1.1	1.8	-0.9	1.3	1.2	-0.3	1.2
Short access total locomotion	0.2	0.2	0.3	-0.6	0.6	0.3	0.2	0.3
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.1	0.3	0.4	-0.0	0.4
Compulsive drug intake	0.2	0.2	0.6	-0.1	0.8	0.2	-0.2	0.3
One hour access (shock baseline)	0.9	1.0	2.2	0.7	-1.5	-0.8	1.0	-0.9
Social response proportion	1.2	1.3	1.7	0.9	-1.1	-1.3	1.2	-1.3
Social responses	2.4	3.0	4.8	2.2	-1.6	-1.7	1.6	-1.6
Social time	0.5	0.7	1.3	0.9	0.5	0.7	-1.1	0.8
Soleus weight	0.3	1.0	1.5	0.8	-1.2	-1.0	0.8	-1.0
Bone: stiffness	1.7	2.6	5.2	2.3	-1.6	-1.5	1.2	-1.4
Tibialis anterior weight	2.7	9.1	12.0	1.9	-3.5	-3.4	2.9	-3.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.0	0.5	0.2	0.7	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.4	0.1	0.4	-0.6	0.4
Time to tail flick, test, before self-admin	2.2	2.2	3.2	-0.5	1.8	1.7	-1.4	1.6
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.1	-0.6	-0.1	-0.6	0.1
Delta time to tail flick, test, before/after SA	1.1	1.0	1.4	0.2	-1.0	-1.2	1.1	-1.2
Tibia length	1.8	5.0	11.8	3.4	-1.7	-1.7	1.8	-2.0
Ambulatory time before self-admin	0.2	0.2	0.7	0.9	0.1	0.3	-0.1	0.1
Ambulatory time after self-admin	1.5	1.6	2.6	-0.3	1.4	1.2	-1.6	1.4
Bone: tissue strength	0.1	0.1	0.1	-0.3	0.3	0.2	-0.3	0.2
Total heroin consumption	0.1	0.1	0.5	-0.7	-0.0	-0.2	0.1	-0.3
Bone: trabecular number	0.5	0.7	1.2	-0.4	0.8	0.9	-1.1	0.9
Bone: trabecular spacing	0.2	0.3	0.5	0.3	-0.5	-0.6	0.7	-0.6
Bone: trabecular thickness	0.1	0.2	0.3	0.4	-0.6	-0.3	0.2	-0.3
Bone: trabecular tissue density	0.6	0.8	1.0	-0.7	-0.9	-0.9	1.0	-1.0
Water consumed over 24 hours	0.5	0.6	1.1	-0.0	0.7	0.8	-1.0	0.8
Number of responses in last shaping day	0.8	0.8	1.9	0.4	-0.9	-0.9	1.4	-0.7