Hub : Genes

Sec14l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Sec14l2 0.09 0.04 2.2e-13 0.11 0.12 0.1 0.12 3.8e-12 1.1e-12 1.2e-11 5.1e-13
2 Brain gene expression Sec14l2 0.23 0.08 0.0e+00 0.28 0.26 0.26 0.27 6.6e-26 1.3e-23 2.1e-24 2.2e-25
3 Liver intron excision ratio chr14_78975267_78980174 0.03 0.02 1.2e-04 0.03 0.03 0.03 0.03 4.3e-04 4.8e-04 6.1e-04 5.0e-04
4 BLA mRNA stability Sec14l2 0.07 0.04 1.9e-03 0.04 0.04 0.04 0.03 4.8e-03 3.0e-03 2.9e-03 1.3e-02
5 PL isoform ratio XM_039091558.1 0.03 0.02 2.7e-03 0.02 0.02 0.02 0.02 2.3e-03 3.3e-03 3.9e-03 4.9e-03
6 Liver intron excision ratio chr14_78980343_78980455 0.03 0.02 1.3e-04 0.03 0.03 0.03 0.03 3.2e-04 4.9e-04 3.9e-04 4.8e-04
7 OFC gene expression Sec14l2 0.19 0.1 3.2e-03 0.08 0.08 0.05 0.07 5.1e-03 5.8e-03 2.2e-02 1.0e-02
8 pVTA mRNA stability Sec14l2 0.11 0.06 1.4e-04 0.11 0.06 0.07 0.07 1.6e-05 1.0e-03 6.8e-04 4.0e-04
9 PL mRNA stability Sec14l2 0.12 0.1 4.2e-08 0.1 0.05 0.08 0.09 2.1e-11 6.9e-06 3.6e-09 6.8e-10
10 Brain mRNA stability Sec14l2 0.1 0.05 2.6e-08 0.1 0.1 0.09 0.1 2.5e-09 2.2e-09 2.1e-08 5.9e-10
11 Brain intron excision ratio chr14_78975267_78980455 0.03 0.02 6.0e-03 0.02 0.02 0.01 0.01 3.4e-03 9.4e-03 7.4e-02 2.1e-02
12 PL intron excision ratio chr14_78975267_78980455 0.05 0.03 4.7e-05 0.02 0.03 0.03 0.02 1.5e-03 1.7e-04 6.5e-04 1.6e-03
13 Liver gene expression Sec14l2 0.15 0.06 6.3e-15 0.11 0.11 0.1 0.11 2.4e-12 4.7e-12 5.9e-11 1.7e-12
14 LHb isoform ratio XM_039091558.1 0.29 0.16 6.9e-03 0.08 0.05 0.11 0.09 5.6e-03 2.3e-02 1.2e-03 3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.71.20.7-1.01.00.41.1-0.9-0.70.70.7-0.60.6-0.80.9-1.1
Area under the delay curve8.89.311.9-3.43.3-3.3-3.2-3.23.23.1-3.4-2.93.3-3.23.1-2.01.4
BMI with tail0.72.312.8-1.10.8-0.8-0.8-0.70.51.0-1.9-1.12.0-2.00.9-3.60.8
BMI without tail0.20.53.8-0.40.2-0.2-0.4-0.20.10.2-0.8-0.20.9-0.9-0.1-1.9-0.5
Body weight1.56.310.5-2.72.3-2.3-2.8-2.31.92.6-3.2-2.73.1-3.01.9-2.3-0.2
Weight adjusted by age0.80.91.9-1.00.7-0.7-0.9-1.00.40.9-1.4-0.81.3-1.30.7-1.4-0.0
Bone surface0.20.30.6-0.50.4-0.4-0.7-0.30.60.7-0.7-0.80.8-0.70.5-0.00.1
Bone volume0.10.10.3-0.30.1-0.1-0.5-0.00.30.3-0.3-0.30.3-0.20.20.5-0.5
Breakpoint value in progressive ratio session0.30.30.6-0.70.8-0.8-0.4-0.60.70.20.1-0.30.5-0.60.70.10.1
Number of licking bursts1.11.32.4-1.51.5-1.5-1.6-1.21.41.0-0.6-0.80.5-0.50.50.3-1.5
Context. condit. distance diff. score2.32.84.22.0-1.91.92.12.0-1.9-1.81.51.7-1.51.5-1.6-0.3-0.4
Locomotion velocity, session 10.30.33.00.4-0.20.20.50.2-0.1-0.20.30.2-0.20.20.50.71.7
Locomotion distance, session 11.41.93.81.7-1.91.91.41.8-1.7-1.30.91.2-0.90.9-1.20.20.1
Locomotion velocity, session 20.60.85.60.30.1-0.10.6-0.1-0.1-0.50.90.5-0.70.70.62.41.4
Locomotion distance, session 21.62.23.71.8-1.61.61.91.7-1.3-1.51.71.4-1.51.5-1.00.21.2
Locomotion velocity, session 31.01.22.51.4-1.51.51.31.5-1.6-1.00.60.9-0.50.5-0.9-0.50.4
Locomotion distance, session 30.60.72.5-0.50.6-0.6-0.5-0.70.60.9-0.9-0.90.9-1.00.9-0.51.6
Stereotopy head waving bouts, day 31.51.82.71.6-1.61.61.31.6-1.5-1.41.21.3-1.21.3-1.20.7-0.5
Stereotopy head waving duration, day 32.63.14.82.2-2.22.21.92.2-2.1-1.81.61.8-1.51.5-1.70.2-0.3
Locomotion velocity, session 70.10.11.00.10.0-0.0-0.2-0.10.30.2-0.1-0.20.3-0.30.40.11.0
Locomotion distance, session 70.50.71.51.2-1.11.10.91.1-0.7-0.60.70.6-0.50.5-0.5-0.50.9
Stereotopy head waving bouts, day 70.10.21.8-0.1-0.00.00.10.1-0.10.1-0.4-0.10.4-0.40.1-1.40.2
Stereotopy head waving duration, day 70.30.42.4-0.40.3-0.3-0.4-0.20.20.5-0.8-0.50.7-0.70.2-1.6-0.0
Locomotion velocity, session 81.61.93.61.4-1.01.01.71.1-0.9-1.51.91.5-1.71.8-0.91.60.3
Locomotion distance, session 87.010.314.43.8-3.63.63.83.7-3.4-3.53.43.4-3.23.2-3.10.4-0.4
Degree of sensitization distance5.15.16.62.5-2.42.42.32.4-2.3-2.42.62.4-2.42.5-2.20.9-1.2
Degree of sensitization stereotypy0.60.62.0-0.90.8-0.8-0.7-0.70.70.7-0.8-0.70.8-0.80.5-1.4-0.1
Conditioned locomotion0.40.52.80.6-0.80.80.41.0-0.7-0.50.20.4-0.20.2-0.7-1.7-0.3
Cocaine response after cond. corrected0.91.01.6-1.00.7-0.7-1.3-0.80.81.2-1.2-1.31.2-1.21.1-0.30.4
Cocaine response after cond. not corrected1.71.93.6-1.41.1-1.1-1.8-0.91.11.6-1.9-1.71.7-1.71.3-0.3-0.1
Cocaine response before conditioning0.10.10.3-0.00.0-0.0-0.20.4-0.10.1-0.6-0.20.4-0.4-0.10.4-0.5
Saline control response1.01.32.71.4-1.51.51.51.2-1.3-0.90.80.8-0.60.6-0.40.51.6
Bone: connectivity density0.30.41.20.8-1.01.00.41.1-0.9-0.50.30.4-0.30.3-0.70.1-0.5
Bone: cortical apparent density0.10.10.5-0.20.2-0.2-0.0-0.40.2-0.10.10.20.0-0.0-0.1-0.7-0.2
Bone: cortical area2.33.55.2-2.11.8-1.8-2.3-1.81.92.1-2.3-2.12.1-2.21.5-0.8-0.1
Bone: cortical porosity0.30.40.7-0.60.6-0.6-0.8-0.20.50.7-0.8-0.70.7-0.70.4-0.2-0.2
Bone: cortical porosity0.10.10.2-0.20.3-0.3-0.30.20.30.3-0.4-0.40.3-0.30.0-0.4-0.3
Bone: cortical thickness1.62.64.0-1.71.4-1.4-2.0-1.31.61.8-2.0-1.81.8-1.90.9-1.4-0.5
Bone: cortical thickness0.50.63.90.5-0.80.80.20.9-0.7-0.2-0.00.20.1-0.1-0.9-2.0-0.6
Bone: cortical tissue density0.10.10.5-0.30.3-0.3-0.1-0.50.3-0.10.00.20.1-0.10.0-0.7-0.2
Condit. Reinf. active minus inactive responses0.30.43.10.1-0.20.2-0.1-0.20.00.6-0.3-0.60.7-0.60.8-0.11.8
Condit. Reinf. active-inactive response ratio0.40.54.80.5-0.30.30.80.00.0-0.00.60.1-0.10.20.60.32.2
Condit. Reinf. active responses0.10.21.10.4-0.60.60.10.2-0.30.2-0.0-0.30.3-0.20.2-0.11.1
Condit. Reinf. inactive responses0.10.11.5-0.1-0.10.1-0.50.1-0.20.1-0.2-0.20.1-0.1-0.4-0.0-1.2
Incentive salience index mean0.70.82.6-0.50.3-0.3-0.7-0.70.41.1-1.0-1.21.2-1.21.1-0.31.6
Condit. Reinf. lever presses0.50.71.3-0.70.3-0.3-0.9-0.70.10.9-1.1-1.11.1-1.10.7-0.70.6
Condit. Reinf. active minus inactive responses0.70.91.41.2-1.11.11.00.9-1.1-1.00.91.1-0.90.8-0.90.7-0.1
Condit. Reinf. active-inactive response ratio0.10.10.70.1-0.20.2-0.0-0.2-0.20.1-0.3-0.10.3-0.40.2-0.50.8
Condit. Reinf. active responses1.72.43.92.0-1.81.81.91.6-1.9-1.61.41.7-1.31.3-1.30.90.6
Condit. Reinf. inactive responses2.43.04.42.0-1.91.92.11.9-1.9-1.81.81.9-1.61.7-1.51.0-0.0
Condit. Reinf. lever presses0.50.71.31.1-1.01.01.01.0-1.0-0.80.60.8-0.60.6-0.8-0.30.5
Condit. Reinf. lever reinforcers received1.42.03.61.9-1.81.81.71.6-1.8-1.41.11.4-1.01.0-1.10.30.8
Conditioned reinforcement - actives1.81.83.2-1.31.2-1.2-1.4-1.31.31.8-1.4-1.61.4-1.31.3-1.50.9
Conditioned reinforcement - inactives2.73.04.3-1.81.6-1.6-1.8-1.71.71.9-1.7-2.12.1-2.01.9-0.71.3
Conditioned locomotion0.50.61.3-0.80.7-0.7-1.0-0.80.80.8-1.1-0.70.8-0.60.60.1-0.3
Patch foraging indifference point 0 sec0.10.10.5-0.50.4-0.4-0.4-0.70.30.00.10.10.00.00.1-0.1-0.4
Patch foraging indifference point AUC0.50.52.30.7-0.50.50.80.7-0.8-0.80.20.8-0.10.10.11.11.5
Delay disc. indifference point, 0s delay6.87.515.6-2.72.5-2.5-2.6-2.52.52.7-3.3-2.63.1-3.02.4-4.01.0
Delay disc. indifference point, 16s delay5.75.78.0-2.72.7-2.7-2.4-2.82.62.4-2.7-2.32.2-2.22.7-0.81.3
Delay disc. indifference point, 2s delay5.86.48.8-2.72.3-2.3-2.7-2.32.42.8-2.9-2.83.0-2.92.2-2.60.7
Delay disc. indifference point, 24s delay5.25.07.2-2.22.1-2.1-2.3-2.12.12.6-2.4-2.72.5-2.52.3-1.91.3
Delay disc. indifference point, 4s delay5.35.68.6-2.32.3-2.3-2.6-2.12.32.7-2.9-2.72.7-2.72.3-1.41.2
Delay disc. indifference point, 8s delay1.92.03.1-1.61.8-1.8-1.3-1.61.61.2-1.4-0.81.5-1.41.5-0.51.2
Indifference point function ln k0.20.31.90.3-0.50.5-0.50.5-0.30.30.1-0.3-0.10.0-0.50.4-1.4
Indifference point function log k0.20.31.90.3-0.50.5-0.50.5-0.30.30.1-0.3-0.10.0-0.50.4-1.4
Patch foraging total patch changes 0 sec0.10.20.6-0.70.6-0.6-0.5-0.80.50.1-0.1-0.00.2-0.10.3-0.0-0.1
Patch foraging total patch changes 12 sec0.10.10.2-0.30.3-0.3-0.2-0.20.1-0.3-0.30.30.3-0.20.1-0.5-0.2
Patch foraging total patch changes 18 sec0.60.82.6-0.81.2-1.2-0.3-1.10.90.4-0.6-0.40.7-0.61.10.21.6
Patch foraging total patch changes 24 sec2.02.54.51.8-1.61.62.11.2-1.9-1.91.71.9-1.41.5-1.3-0.70.8
Patch foraging total patch changes 6 sec0.10.20.6-0.30.3-0.3-0.2-0.4-0.10.1-0.3-0.00.3-0.20.50.80.8
Patch foraging time to switch 0 sec0.50.85.3-0.20.3-0.30.2-0.40.3-0.10.60.2-0.80.7-0.9-2.3-1.9
Patch foraging water rate 0 sec0.50.85.2-0.60.5-0.5-0.7-0.40.30.3-0.8-0.41.0-0.90.92.31.0
Patch foraging water rate 12 sec0.20.31.80.5-0.50.50.20.9-0.4-0.1-0.10.00.1-0.1-0.21.30.7
Patch foraging water rate 18 sec1.52.04.31.4-1.71.70.71.6-1.6-1.21.01.1-1.11.0-1.90.9-2.1
Patch foraging water rate 24 sec0.40.54.40.6-0.30.30.30.7-0.2-0.30.50.3-0.60.6-0.52.1-0.2
Patch foraging water rate 6 sec0.20.32.60.3-0.40.4-0.10.8-0.10.0-0.1-0.0-0.10.1-0.41.6-0.4
Seeking ratio, delayed vs. immediate footshock0.50.64.50.2-0.10.10.50.3-0.1-0.80.61.3-0.40.40.22.10.7
Distance traveled before self-admin0.20.21.0-0.10.1-0.10.3-0.40.1-0.70.30.60.1-0.00.41.00.7
Distance traveled after self-admin0.30.30.6-0.50.7-0.7-0.2-0.80.6-0.2-0.40.00.6-0.60.6-0.60.7
Extensor digitorum longus weight2.28.614.5-3.32.8-2.8-3.8-2.93.03.3-3.4-3.33.3-3.32.5-0.60.2
Bone: elastic displacement0.60.72.30.7-0.70.70.60.8-0.7-0.70.70.7-0.80.7-1.20.1-1.5
Bone: elastic work0.40.55.3-0.1-0.20.2-0.30.4-0.1-0.1-0.00.1-0.20.1-0.90.1-2.3
Bone: endosteal estimation0.00.00.4-0.20.1-0.1-0.2-0.10.20.0-0.10.0-0.10.10.10.6-0.3
Bone: endosteal perimeter0.61.21.6-1.21.2-1.2-1.2-1.11.21.2-1.2-1.21.1-1.01.10.50.4
Epididymis fat weight0.20.52.8-0.50.5-0.5-0.2-0.20.10.1-0.3-0.10.0-0.1-0.4-1.6-1.7
Delta time in closed arm before/after self-admin3.93.85.72.2-2.32.32.12.4-2.4-2.41.91.9-1.51.4-1.80.3-1.1
Delta time in open arm before/after self-admin5.45.28.4-2.62.9-2.9-2.2-2.72.82.2-2.1-2.11.9-1.92.3-0.71.3
Diff in mean of infusions in LGA sessions0.30.31.9-0.40.6-0.60.1-0.30.6-0.0-0.3-0.40.5-0.50.4-1.40.6
Delay discount exponential model param8.38.711.03.3-3.13.13.13.1-3.0-3.13.32.9-3.23.2-2.92.0-1.4
Extinction: sum of active levers before priming1.61.63.2-1.21.2-1.2-0.9-1.21.11.0-1.1-1.11.5-1.51.8-0.41.7
Active lever presses in extinction session 61.21.21.8-1.11.1-1.1-1.3-0.81.01.3-1.0-1.31.3-1.41.0-0.70.0
Bone: final force0.10.20.8-0.50.4-0.4-0.3-0.30.50.3-0.3-0.30.3-0.3-0.0-0.9-0.3
Bone: final moment0.10.20.4-0.60.6-0.6-0.5-0.40.70.4-0.4-0.40.3-0.30.0-0.5-0.5
Food consumed during 24 hour testing period0.30.43.0-0.30.5-0.5-0.2-0.70.40.10.3-0.0-0.10.10.61.70.9
Glucose14.121.233.0-4.75.4-5.4-3.9-5.05.14.6-3.6-4.54.1-4.15.71.45.2
Heart weight0.30.40.90.5-0.70.70.60.6-0.9-0.40.90.4-0.70.7-0.50.10.1
Delay discount hyperbolic model param8.69.111.83.3-3.13.13.13.1-3.1-3.23.43.0-3.33.3-3.02.2-1.4
Intermittent access intake day 1-15 change1.01.01.8-0.91.0-1.0-0.7-1.10.90.9-1.0-1.01.2-1.21.3-0.31.1
Intermittent access intake escalation0.50.51.0-0.70.8-0.8-0.4-0.90.60.6-0.6-0.70.9-0.91.0-0.30.7
Intermittent access intake escalation 20.10.10.5-0.20.3-0.30.1-0.40.1-0.40.60.4-0.20.20.10.7-0.1
Intermitt. access day 1 inactive lever presses0.60.61.50.9-1.21.20.80.9-1.1-0.60.20.40.2-0.2-0.20.70.8
Intermitt. access day 15 inactive lever presses0.60.72.6-0.50.6-0.6-0.5-0.70.70.7-0.6-0.91.0-1.01.10.31.6
Intermitt. access escalation Index0.20.20.40.5-0.40.40.60.1-0.5-0.20.00.1-0.20.2-0.2-0.60.6
Intermittent access day 1 total infusions0.60.72.2-1.01.0-1.0-0.6-1.01.20.6-0.6-0.60.4-0.40.4-1.50.0
Intermittent access day 15 total infusions1.92.13.1-1.61.6-1.6-1.2-1.71.71.5-1.4-1.51.3-1.21.3-1.50.8
Intermittent access terminal intake (last 3 days)0.60.71.5-0.91.1-1.1-0.6-1.01.20.7-0.7-0.80.7-0.60.8-0.70.5
Intermittent access total infusions0.80.91.8-1.11.2-1.2-0.9-1.11.31.0-0.8-1.10.8-0.70.8-0.50.2
Intermittent access day 1 locomotion0.70.81.60.9-0.70.71.20.7-0.5-1.20.91.0-1.21.3-0.9-0.10.1
Intermittent access day 15 total locomotion2.32.53.5-1.71.9-1.9-1.3-1.81.81.2-1.6-1.31.7-1.61.4-1.90.5
Intermittent access total locomotion0.91.01.6-1.01.3-1.3-0.7-1.11.30.7-1.0-1.11.0-0.91.1-0.61.0
Intermittent access standard deviation0.40.50.80.8-0.70.70.90.5-0.6-0.80.70.5-0.70.8-0.80.2-0.0
Left kidney weight0.51.45.01.1-1.31.30.81.2-1.0-0.91.00.9-1.11.1-1.7-0.2-2.2
Right kidney weight0.82.26.81.2-1.71.71.01.5-1.6-1.20.91.1-1.01.0-2.0-1.4-2.6
Cocaine induced anxiety1.01.12.7-1.01.1-1.1-1.0-1.01.10.9-0.9-1.00.9-0.91.31.61.1
Post-drug Anxiety0.70.71.1-0.90.9-0.9-0.9-0.71.00.9-0.3-1.00.7-0.81.01.00.8
Baseline Anxiety0.60.72.3-0.90.9-0.9-0.8-1.01.00.9-0.2-0.80.4-0.40.5-1.5-0.5
Tail length0.41.23.1-1.20.8-0.8-1.8-0.80.91.0-1.2-1.11.0-0.90.41.3-1.5
Length with tail0.82.95.9-2.01.7-1.7-2.4-1.61.51.9-1.8-1.91.5-1.51.01.0-1.7
Length without tail1.02.23.4-1.81.7-1.7-1.7-1.61.51.7-1.5-1.71.3-1.41.40.1-0.2
Times rat made contact with spout0.60.73.5-0.10.6-0.60.4-0.70.5-0.10.70.2-0.50.50.81.91.7
Lifetime Intake0.70.71.4-1.01.0-1.0-1.0-1.01.20.9-0.8-1.00.7-0.60.8-0.40.1
Liver weight, left3.96.38.62.6-2.92.92.42.8-2.6-2.72.22.8-2.32.2-2.70.5-2.3
Liver weight, right4.47.310.83.0-3.13.12.73.2-2.7-2.62.62.6-2.62.6-3.3-1.0-2.0
Locomotor activity0.61.04.4-0.91.2-1.2-0.8-1.00.90.8-0.3-0.90.3-0.21.02.10.9
Locomotor testing distance0.20.41.1-0.60.6-0.6-1.1-0.40.60.7-0.7-0.80.6-0.50.20.3-0.4
Locomotor testing rearing1.72.63.9-1.71.6-1.6-2.0-1.61.81.9-1.5-1.91.6-1.61.60.70.8
Locomotion in novel chamber0.60.72.20.7-1.01.00.81.1-1.1-0.60.60.5-0.50.4-1.0-1.5-0.7
Locomotion in novel chamber post-restriction1.11.42.81.3-1.11.11.71.2-0.9-1.31.31.4-1.11.1-0.7-0.51.2
Fecal boli incidents, locomotor time 10.50.61.10.8-0.80.80.80.7-1.0-0.80.80.8-0.80.8-0.40.70.2
Change in fecal boli incidents, locomotor task0.40.41.40.5-0.20.20.80.3-0.1-0.61.20.7-0.40.5-0.20.90.8
Time >=10cm from walls, locomotor time 10.50.55.4-0.10.0-0.00.40.1-0.0-0.40.40.6-0.10.1-0.5-2.3-0.7
Bouts of movement, locomotor time 10.40.41.2-0.20.2-0.2-0.1-0.50.30.7-0.7-0.70.7-0.70.7-1.11.1
Total resting periods, locomotor time 10.70.82.6-0.30.4-0.4-0.2-0.50.51.0-0.9-1.01.0-1.01.0-1.21.6
Rest time, locomotor task time 10.20.21.50.4-0.40.40.20.3-0.30.30.3-0.60.00.00.20.21.2
Distance moved, locomotor task time 10.30.42.7-0.20.3-0.3-0.2-0.40.3-0.50.20.5-0.80.7-0.50.1-1.6
Vertical activity count, locomotor time 10.30.30.7-0.10.5-0.50.2-0.50.3-0.60.30.8-0.80.8-0.20.6-0.9
Time >=10cm from walls, locomotor time 20.20.20.50.5-0.10.10.50.4-0.1-0.60.70.7-0.40.4-0.4-0.10.0
Bouts of movement, locomotor time 20.30.31.20.1-0.40.40.10.5-0.30.0-1.10.00.9-0.90.1-0.90.4
Total resting periods, locomotor time 20.40.41.40.1-0.40.40.00.4-0.20.2-1.2-0.11.0-1.00.3-1.00.8
Rest time, locomotor task time 20.40.40.90.8-0.90.90.70.8-0.9-0.40.60.2-0.40.4-0.50.50.4
Distance moved, locomotor task time 20.20.20.80.10.2-0.20.1-0.20.2-0.40.20.4-0.70.7-0.4-0.3-0.9
Vertical activity count, locomotor time 20.10.10.3-0.20.6-0.6-0.1-0.30.6-0.1-0.30.10.0-0.00.2-0.1-0.3
Light reinforcement 10.20.30.9-0.2-0.30.3-0.6-0.2-0.10.4-0.9-0.51.0-1.00.1-0.6-0.3
Light reinforcement 20.20.31.70.2-0.40.40.2-0.1-0.6-0.60.30.6-0.40.3-0.8-0.1-1.3
Bone: marrow area0.00.00.3-0.20.1-0.1-0.1-0.10.2-0.0-0.10.0-0.10.10.10.5-0.2
Bone: maximum diameter3.25.97.8-2.82.6-2.6-2.8-2.72.72.6-2.6-2.62.5-2.52.40.20.7
Bone: maximum force0.10.10.7-0.40.4-0.4-0.2-0.30.40.1-0.10.0-0.00.0-0.2-0.2-0.8
Bone: maximum moment0.10.21.3-0.50.6-0.6-0.4-0.40.50.1-0.2-0.0-0.00.0-0.20.3-1.1
Mean time between licks in bursts0.40.64.90.5-0.10.10.60.3-0.2-0.50.90.6-0.60.60.22.20.9
Mean num. licks in bursts1.21.46.01.4-1.01.01.80.7-1.0-1.01.10.9-0.80.9-0.01.02.5
Cd content in liver1.11.22.41.2-1.31.31.11.1-1.5-1.11.11.1-1.01.1-1.2-0.3-0.7
Co content in liver0.40.40.9-0.30.1-0.1-0.60.1-0.20.7-0.9-0.80.9-0.90.6-0.90.8
Cu content in liver0.10.10.2-0.2-0.10.1-0.4-0.1-0.10.3-0.3-0.30.3-0.40.3-0.40.0
Fe content in liver0.60.72.50.8-0.30.31.10.2-0.5-0.81.00.9-0.80.80.21.61.3
K content in liver0.90.92.2-0.90.4-0.4-1.3-0.50.51.2-1.5-1.21.3-1.30.7-0.8-0.2
Mg content in liver2.02.13.7-1.51.1-1.1-1.8-1.31.11.7-1.9-1.81.8-1.81.3-0.50.2
Mn content in liver0.10.10.4-0.1-0.10.1-0.40.20.20.3-0.7-0.40.5-0.50.10.2-0.2
Na content in liver6.46.79.1-2.62.6-2.6-2.5-2.42.82.8-2.7-2.82.8-2.83.0-0.32.3
Rb content in liver1.01.22.1-1.21.0-1.0-1.5-1.30.91.3-1.2-1.21.1-1.11.0-0.70.1
Se content in liver1.51.83.1-1.71.3-1.3-1.7-1.41.11.5-1.5-1.51.4-1.41.30.7-0.2
Sr content in liver0.80.71.7-0.91.3-1.3-0.5-1.11.00.7-0.3-0.60.3-0.30.80.90.7
Zn content in liver0.40.43.9-0.30.4-0.4-0.4-0.40.2-0.00.20.1-0.30.2-0.12.0-1.0
Bone: minimum diameter0.10.10.40.2-0.30.30.00.4-0.2-0.2-0.00.2-0.20.1-0.40.5-0.6
Time in familiar zone, hab. session 11.01.02.20.9-0.50.51.20.6-0.5-1.01.51.2-1.41.4-1.0-0.0-0.5
Time in novel zone, hab. session 10.60.61.2-0.80.5-0.5-1.1-0.60.40.7-1.0-0.90.9-0.90.60.7-0.3
Total zone transitions, hab. session 10.40.50.90.9-0.60.60.90.7-0.0-0.71.00.8-0.80.8-0.40.60.9
Total locomotion distance, hab. session 10.10.21.30.3-0.10.10.20.10.3-0.0-0.10.00.1-0.10.30.81.1
Locomotion velocity, hab. session 10.20.21.90.5-0.40.40.40.40.2-0.10.00.10.1-0.10.30.31.4
Time in familiar zone, hab. session 23.43.55.12.0-1.81.82.31.8-1.9-2.12.02.3-2.02.0-1.9-0.2-1.0
Time in novel zone, hab. session 22.32.33.7-1.81.7-1.7-1.9-1.81.61.6-1.4-1.71.4-1.41.40.50.4
Total zone transitions, hab. session 20.10.21.4-0.10.2-0.2-0.2-0.10.30.3-0.3-0.40.4-0.40.50.41.2
Total locomotion distance, hab. session 20.40.51.3-0.60.7-0.7-0.5-0.70.80.6-0.5-0.60.6-0.60.90.81.1
Locomotion velocity, hab. session 20.60.91.6-0.80.9-0.9-0.8-0.91.00.9-0.8-0.90.9-0.91.10.51.3
Novel to familiar place preference ratio2.42.56.6-1.31.3-1.3-1.3-1.31.31.7-1.6-1.81.8-1.71.9-0.52.6
Novelty place preference2.22.25.4-1.21.2-1.2-1.2-1.21.31.6-1.5-1.71.7-1.61.8-0.22.3
Time in novel zone, NPP test1.81.84.9-1.11.1-1.1-1.1-1.11.11.5-1.4-1.61.5-1.41.7-0.02.2
Total zone transitions, NPP test0.20.30.80.7-0.90.90.30.9-0.6-0.40.10.3-0.10.1-0.5-0.5-0.2
Total locomotion distance, NPP test0.10.10.20.1-0.30.3-0.10.2-0.10.1-0.3-0.10.3-0.30.1-0.50.4
Locomotion velocity, NPP test0.20.20.5-0.2-0.00.0-0.4-0.10.20.4-0.7-0.50.6-0.70.5-0.70.5
Intraocular pressure0.20.22.1-0.10.5-0.50.1-0.50.30.30.2-0.30.00.00.4-0.11.5
Delta distance traveled before/after self-admin0.50.63.1-0.40.7-0.7-0.5-0.30.70.7-1.0-0.70.5-0.60.3-1.80.2
Delta ambulatory time before/after self-admin0.10.21.70.00.2-0.2-0.00.20.10.3-0.5-0.20.0-0.0-0.0-1.3-0.0
Parametrial fat weight1.42.87.5-1.51.4-1.4-1.1-2.01.41.7-1.3-1.71.6-1.52.2-0.52.7
Pavlov. Cond. lever latency0.40.50.9-0.70.8-0.8-0.6-0.70.80.7-0.6-0.60.6-0.61.00.60.6
Pavlov. Cond. magazine entry latency1.01.31.91.3-1.21.21.41.0-1.1-1.31.21.2-1.21.2-1.00.8-0.0
Pavlov. Cond. change in total contacts0.80.81.6-0.81.0-1.0-0.7-1.11.10.8-0.6-0.90.8-0.71.0-0.21.3
Pavlov. Cond. index score1.11.41.91.4-1.41.41.41.2-1.3-1.31.21.2-1.11.1-1.20.0-0.1
Pavlov. Cond. latency score1.11.41.81.3-1.31.31.31.2-1.2-1.31.21.3-1.21.2-1.3-0.0-0.3
Pavlov. Cond. lever contacts0.50.60.80.8-0.80.80.80.7-0.9-0.90.80.8-0.70.7-0.9-0.3-0.3
Pavlov. Cond. magazine entry number1.01.22.1-1.41.2-1.2-1.5-1.11.21.2-1.1-1.11.0-1.00.8-0.7-0.8
Pavlov. Cond. intertrial magazine entries0.30.41.0-0.1-0.40.4-0.90.2-0.10.6-0.9-0.70.7-0.8-0.1-0.8-1.0
Pavlov. Cond. lever-magazine prob. diff.1.21.52.11.4-1.41.41.41.2-1.4-1.31.21.3-1.11.1-1.30.0-0.3
Pavlov. Cond. response bias0.10.20.40.6-0.60.60.50.4-0.6-0.40.30.3-0.20.2-0.30.10.3
Pavlov. Cond. lever latency1.62.14.1-1.71.4-1.4-2.0-1.51.51.7-1.5-1.61.4-1.41.0-0.5-1.1
Pavlov. Cond. magazine entry latency0.10.10.2-0.20.4-0.4-0.1-0.10.30.2-0.1-0.20.1-0.10.0-0.50.1
Pavlov. Cond. change in total contacts0.60.91.71.1-0.80.81.30.9-0.8-1.01.11.0-1.01.0-0.8-0.00.8
Pavlov. Cond. index score0.81.01.91.2-0.90.91.41.1-1.0-1.11.01.1-1.01.0-0.80.00.7
Pavlov. Cond. latency score0.81.01.81.2-0.90.91.41.2-1.0-1.11.01.1-1.01.0-0.90.10.6
Pavlov. Cond. lever contacts1.92.55.01.9-1.61.62.21.6-1.6-1.81.71.7-1.61.6-1.10.51.2
Pavlov. Cond. magazine entry number0.10.10.20.2-0.50.5-0.00.2-0.40.0-0.2-0.10.2-0.20.00.0-0.0
Pavlov. Cond. intertrial magazine entries0.10.10.40.4-0.60.60.10.5-0.6-0.1-0.10.00.1-0.1-0.10.3-0.0
Pavlov. Cond. lever-magazine prob. diff.0.81.01.91.2-0.90.91.41.1-1.0-1.11.11.1-1.11.1-0.90.10.4
Pavlov. Cond. response bias0.71.02.11.1-0.70.71.50.8-0.8-1.21.21.2-1.11.1-0.70.10.9
Time in closed arm before self-admin0.30.31.00.3-0.30.30.30.4-0.3-0.60.10.6-0.80.8-0.90.2-1.0
Time in closed arm after self-admin3.43.55.42.0-2.02.01.72.1-2.1-2.31.52.0-1.71.7-2.10.6-1.9
Time in open arm before self-admin0.10.10.50.5-0.70.70.10.6-0.50.10.2-0.10.1-0.2-0.20.1-0.2
Time in open arm after self-admin1.21.33.2-1.01.2-1.2-0.8-1.21.21.2-0.8-1.11.1-1.11.4-0.51.8
Bone: periosteal estimation0.51.11.8-1.31.1-1.1-1.4-1.01.21.1-1.3-1.11.1-1.10.80.0-0.3
Bone: periosteal perimeter2.23.65.2-2.11.9-1.9-2.1-1.82.02.1-2.3-2.12.1-2.11.7-0.60.4
Bone: post-yield work0.30.41.9-0.70.8-0.8-0.4-0.80.70.10.1-0.0-0.30.30.31.4-0.5
Progressive ratio test 1 active lever presses2.02.13.0-1.41.3-1.3-1.4-1.51.51.6-1.5-1.61.6-1.61.7-0.41.4
Progressive ratio test 1 breakpoint1.51.52.1-1.11.0-1.0-1.1-1.21.21.4-1.4-1.41.4-1.41.5-0.71.2
Progressive ratio test 1 inactive lever presses2.93.24.9-1.81.7-1.7-1.9-1.91.81.6-1.9-1.92.2-2.22.10.01.1
Progressive ratio test 2 active lever presses1.31.42.7-1.41.5-1.5-1.1-1.41.61.4-0.7-1.10.8-0.81.1-0.80.6
Progressive ratio test 2 breakpoint1.11.32.6-1.31.4-1.4-1.0-1.21.61.3-0.7-1.00.8-0.81.2-0.60.9
Progressive ratio test 2 inactive lever presses3.13.65.8-2.12.2-2.2-1.6-2.42.41.8-1.7-1.81.8-1.71.8-1.51.2
Incentive Sensitization - Responses0.90.91.9-1.21.3-1.3-0.7-1.21.41.1-0.1-0.70.3-0.30.7-1.00.2
Incentive Sensitization - Breakpoint0.90.92.0-1.21.4-1.4-0.7-1.21.41.1-0.1-0.70.3-0.30.6-1.00.1
Sum of active levers in priming session hrs 5-61.00.91.5-1.01.1-1.1-1.0-0.71.11.1-0.6-0.91.2-1.20.9-0.80.1
Progressive ratio0.40.51.2-0.91.1-1.1-0.4-1.11.10.50.1-0.4-0.20.20.2-0.1-0.7
Food seeking constrained by brief footshock2.53.14.7-2.01.9-1.9-2.1-1.92.22.0-1.6-2.11.6-1.71.3-0.7-0.4
Seeking ratio, punishment vs. effort0.50.61.8-0.3-0.00.0-1.0-0.00.10.9-1.3-1.01.3-1.30.7-0.00.4
Retroperitoneal fat weight0.10.32.3-0.10.2-0.20.1-0.10.10.4-0.2-0.50.3-0.20.2-1.50.8
Reaction time number correct0.50.86.20.4-0.10.10.50.4-0.2-0.61.00.7-1.01.0-0.42.50.0
Reaction time mean minus median0.10.10.6-0.30.5-0.50.1-0.80.3-0.10.20.0-0.10.10.40.4-0.0
Reaction time mean minus median AUC0.20.20.7-0.50.6-0.6-0.3-0.80.40.3-0.4-0.40.5-0.50.4-0.4-0.2
Reaction time num false alarms0.91.25.6-0.90.6-0.6-0.9-0.70.71.0-1.3-1.11.2-1.20.6-2.40.2
Reaction time num false alarms AUC0.81.06.6-0.80.4-0.4-0.9-0.70.70.9-1.2-1.01.0-1.00.3-2.6-0.4
Reaction time trials correct on left0.50.86.20.4-0.10.10.50.4-0.2-0.61.00.7-1.01.0-0.42.50.0
Reaction time trials on left0.60.86.30.5-0.20.20.60.5-0.3-0.71.00.7-1.01.0-0.42.50.0
Reaction time mean0.00.10.30.1-0.00.00.1-0.40.2-0.20.30.1-0.30.3-0.1-0.3-0.5
Reaction time mean AUC0.10.10.50.3-0.20.20.3-0.20.0-0.30.30.2-0.30.3-0.2-0.3-0.7
Median of all reaction times0.10.10.50.3-0.30.30.2-0.10.1-0.20.40.1-0.30.3-0.2-0.5-0.7
Reaction time omissions0.10.10.30.5-0.50.50.60.5-0.3-0.2-0.00.10.1-0.0-0.1-0.20.4
Reaction time false alarm rate1.31.912.7-1.00.5-0.5-1.1-0.80.81.1-1.6-1.31.4-1.40.4-3.6-0.5
Reaction time premature initiation rate4.05.39.02.8-3.03.02.52.9-3.0-2.41.92.2-1.71.7-2.4-0.3-0.6
Reaction time premature initiations3.14.46.42.5-2.52.52.32.5-2.5-2.22.02.1-1.81.8-2.11.0-0.3
Std. dev. reaction times0.10.20.8-0.40.5-0.5-0.0-0.90.60.10.1-0.2-0.00.00.4-0.2-0.0
Reaction time trials completed0.60.86.30.5-0.20.20.60.5-0.3-0.71.00.7-1.01.0-0.42.50.0
Reaction time trials AUC0.50.86.60.4-0.10.10.40.4-0.2-0.60.90.7-0.90.9-0.42.6-0.1
Run reversals in cocaine runway, females0.40.43.30.1-0.10.10.6-0.6-0.0-0.20.4-0.0-0.50.5-0.1-1.80.3
Run reversals in cocaine runway, males0.10.10.4-0.10.1-0.1-0.0-0.3-0.1-0.0-0.3-0.00.3-0.20.20.60.1
Latency to leave start box in cocaine runway0.40.41.2-0.20.0-0.0-0.3-0.3-0.00.7-0.8-0.70.8-0.70.6-1.01.1
Latency to leave start box in cocaine runway, F0.30.32.0-0.30.1-0.1-0.3-0.30.10.5-0.7-0.40.6-0.60.1-1.40.3
Latency to leave start box in cocaine runway, M0.40.32.30.1-0.10.1-0.30.1-0.20.5-0.4-0.60.4-0.40.80.81.5
Std. dev. time between licks in bursts0.70.81.41.1-0.80.80.91.0-0.9-0.91.21.0-1.01.0-0.70.90.2
Total sessions with >9 infusions0.10.10.20.3-0.50.50.20.2-0.4-0.00.30.1-0.10.1-0.20.2-0.0
Short access day 1 total inactive lever presses1.21.42.5-1.21.2-1.2-1.6-1.31.51.2-1.3-1.21.1-1.11.10.8-0.0
Short access day 10 total inactive lever presses0.70.81.91.2-1.41.40.81.2-1.3-0.60.20.3-0.10.0-0.51.30.4
Short access day 1 total infusions0.10.10.3-0.0-0.20.2-0.4-0.10.00.2-0.3-0.50.3-0.3-0.1-0.5-0.4
Short access day 10 total infusions0.10.10.30.2-0.20.20.30.2-0.0-0.50.30.3-0.40.5-0.30.3-0.1
Short access total infusions0.00.10.40.0-0.20.2-0.20.00.0-0.0-0.1-0.2-0.10.2-0.30.1-0.6
Short access day 1 locomotion1.82.03.21.4-1.41.41.31.2-1.5-1.81.21.6-1.31.3-1.61.0-1.4
Short access day 10 total locomotion2.02.23.31.6-1.41.41.81.5-1.4-1.81.31.7-1.61.8-1.11.50.5
Short access total locomotion4.95.17.02.6-2.42.42.42.3-2.4-2.71.92.5-2.32.4-2.21.5-0.5
One hour access (0.3 mA shock)0.60.71.3-1.01.0-1.0-0.8-1.01.10.9-0.7-0.70.6-0.70.9-0.30.5
Compulsive drug intake4.14.16.62.4-2.62.62.12.5-2.5-1.81.81.9-1.91.8-2.00.3-0.7
One hour access (shock baseline)4.35.07.6-2.52.6-2.6-2.3-2.62.72.2-2.2-2.22.1-2.02.4-0.31.1
Social response proportion0.40.42.3-0.50.8-0.8-0.3-0.70.60.20.4-0.2-0.20.20.61.50.5
Social responses0.50.62.5-0.81.1-1.1-0.5-0.80.70.40.1-0.30.1-0.10.81.60.6
Social time0.40.51.40.30.0-0.00.70.3-0.5-0.61.10.7-1.11.2-0.40.9-0.5
Soleus weight0.41.32.7-1.41.3-1.3-1.6-1.11.31.0-1.1-0.80.8-0.80.30.9-1.6
Bone: stiffness0.10.21.40.4-0.50.50.40.4-0.4-0.30.00.4-0.00.0-0.2-1.20.5
Tibialis anterior weight1.44.77.3-2.72.5-2.5-2.6-2.42.62.3-2.2-2.22.1-2.02.0-0.10.3
Time to tail flick, vehicle, before self-admin0.40.42.1-0.50.6-0.6-0.4-0.50.70.9-0.1-0.50.2-0.2-0.1-1.4-0.6
Time to tail flick, vehicle, after self-admin0.10.10.80.3-0.10.10.50.3-0.10.00.3-0.0-0.10.2-0.2-0.90.5
Time to tail flick, test, before self-admin0.90.92.11.1-1.11.10.91.5-1.1-0.91.10.8-0.70.7-0.90.80.0
Time to tail flick, test, after self-admin0.70.71.5-1.00.9-0.9-1.2-0.71.00.8-0.3-0.70.7-0.80.51.1-0.3
Delta time to tail flick, vehicle, before/after SA0.20.21.00.4-0.40.40.60.3-0.5-0.50.50.3-0.20.30.0-0.11.0
Delta time to tail flick, test, before/after SA1.00.91.6-1.11.0-1.0-1.2-1.31.11.0-0.9-1.00.8-0.80.90.6-0.1
Tibia length0.30.85.60.4-0.70.70.10.6-0.7-0.60.50.6-0.70.7-1.3-0.8-2.4
Ambulatory time before self-admin0.10.10.6-0.20.2-0.20.1-0.40.1-0.60.30.6-0.00.00.20.80.2
Ambulatory time after self-admin0.10.20.5-0.40.5-0.5-0.0-0.70.4-0.4-0.20.30.2-0.20.5-0.40.5
Bone: tissue strength1.11.13.90.3-0.10.10.50.1-0.1-0.91.31.0-1.41.4-1.01.7-2.0
Total heroin consumption0.10.10.30.0-0.10.10.10.3-0.1-0.50.10.30.0-0.1-0.10.3-0.5
Bone: trabecular number0.20.31.40.4-0.70.7-0.00.8-0.6-0.30.10.2-0.10.1-0.60.3-1.2
Bone: trabecular spacing0.70.92.0-1.11.4-1.4-0.6-1.41.31.0-0.5-0.80.5-0.40.90.20.9
Bone: trabecular thickness1.51.83.91.3-1.51.50.81.8-1.6-1.40.91.3-1.11.1-1.50.5-2.0
Bone: trabecular tissue density0.10.10.40.20.1-0.10.50.0-0.0-0.40.60.5-0.60.6-0.1-0.20.2
Water consumed over 24 hours0.80.96.00.10.3-0.30.5-0.30.2-0.61.30.9-1.21.20.02.40.4
Number of responses in last shaping day0.30.31.40.5-0.40.40.70.1-0.4-0.80.20.6-0.30.2-0.4-1.20.2