Hub : Genes

Sdhb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_063287472.1 0.03 0.02 4.5e-03 0.01 0.01 0.02 0.01 3.6e-02 1.8e-02 2.0e-03 1.0e-02
2 Liver gene expression Sdhb 0.14 0.07 6.0e-10 0.09 0.08 0.08 0.09 2.8e-10 1.6e-09 7.1e-09 6.1e-10
3 NAcc gene expression Sdhb 0.09 0.04 2.8e-09 0.06 0.05 0.04 0.06 1.0e-09 2.0e-08 1.7e-07 8.3e-09
4 PL gene expression Sdhb 0.1 0.07 4.2e-03 0 0 0.01 0.01 7.9e-02 1.3e-01 9.6e-03 5.4e-02
5 LHb gene expression Sdhb 0.28 0.12 3.5e-04 0.11 0.07 0.08 0.08 1.5e-03 9.9e-03 5.9e-03 5.1e-03
6 RMTg gene expression Sdhb 0.25 0.12 6.3e-04 0.14 0.14 0.13 0.13 2.0e-04 1.8e-04 2.1e-04 2.2e-04
7 Adipose gene expression Sdhb 0.13 0.07 7.6e-13 0.12 0.11 0.12 0.12 1.1e-12 7.3e-12 3.9e-13 3.7e-13
8 pVTA gene expression Sdhb 0.2 0.1 7.8e-11 0.13 0.12 0.13 0.13 2.6e-10 2.9e-10 1.6e-10 2.5e-10
9 Adipose mRNA stability Sdhb 0.06 0.03 2.8e-06 0.04 0.05 0.05 0.04 5.5e-05 4.8e-06 5.8e-06 9.5e-06
10 Brain gene expression Sdhb 0.06 0.03 2.2e-05 0.04 0.04 0.04 0.04 2.6e-04 1.1e-04 8.2e-05 9.8e-05
11 BLA gene expression Sdhb 0.09 0.05 2.5e-04 0.02 0.02 0.01 0.01 3.3e-02 3.2e-02 7.6e-02 1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.91.63.51.91.41.41.31.5-1.4-1.01.1-1.30.4-0.2
Area under the delay curve0.20.32.11.40.50.20.40.50.6-0.6-0.1-0.30.20.1
BMI with tail1.03.56.2-1.9-1.7-2.0-2.5-1.11.31.9-2.01.8-2.41.7
BMI without tail0.41.95.9-2.4-1.0-1.1-1.7-1.00.41.2-1.31.3-1.61.3
Body weight0.41.63.7-0.6-0.8-1.0-1.6-0.20.91.2-1.21.2-1.91.8
Weight adjusted by age0.71.94.0-1.0-1.0-1.0-1.4-1.90.61.2-1.51.8-1.32.0
Bone surface0.71.32.81.71.51.41.21.2-1.4-1.00.9-1.00.10.3
Bone volume0.81.55.22.31.41.31.31.3-1.2-1.00.9-1.20.30.1
Breakpoint value in progressive ratio session0.10.20.70.10.20.20.50.3-0.0-0.40.3-0.60.6-0.8
Number of licking bursts0.41.11.70.90.81.01.30.6-1.3-0.81.0-1.31.2-1.1
Context. condit. distance diff. score0.70.91.71.10.70.81.00.6-1.1-0.70.8-1.30.5-1.1
Locomotion velocity, session 11.11.33.41.80.40.31.10.6-0.3-0.90.8-1.51.3-1.8
Locomotion distance, session 11.62.14.61.80.90.71.41.0-0.1-1.41.3-1.82.0-2.1
Locomotion velocity, session 20.60.72.70.90.3-0.00.70.60.3-0.80.7-0.91.2-1.6
Locomotion distance, session 20.40.62.90.8-0.7-1.1-0.5-0.11.70.5-0.60.10.1-0.4
Locomotion velocity, session 30.20.20.7-0.00.40.10.30.8-0.4-0.40.4-0.60.3-0.8
Locomotion distance, session 30.10.10.20.50.20.10.30.1-0.5-0.20.2-0.30.1-0.4
Stereotopy head waving bouts, day 30.20.21.2-0.1-0.2-0.6-0.5-0.31.10.1-0.10.20.2-0.3
Stereotopy head waving duration, day 30.20.20.8-0.60.2-0.1-0.10.10.5-0.40.3-0.30.6-0.9
Locomotion velocity, session 70.30.42.4-0.70.70.80.40.1-1.5-0.30.2-0.1-0.20.1
Locomotion distance, session 70.20.30.90.60.50.70.8-0.2-1.0-0.60.2-0.20.30.1
Stereotopy head waving bouts, day 70.50.51.10.40.80.60.50.7-0.7-0.90.8-1.10.5-0.8
Stereotopy head waving duration, day 70.91.12.40.81.00.80.90.9-0.9-1.01.1-1.50.9-1.3
Locomotion velocity, session 80.40.41.00.7-0.8-0.9-0.4-0.81.00.6-0.70.1-0.4-0.2
Locomotion distance, session 80.60.83.21.80.70.40.80.9-0.5-0.60.6-1.30.4-1.0
Degree of sensitization distance0.30.30.9-0.7-0.4-0.2-0.4-1.00.30.3-0.60.8-0.30.8
Degree of sensitization stereotypy0.60.71.30.21.00.90.61.0-1.1-1.00.8-1.00.3-0.6
Conditioned locomotion0.91.12.6-0.31.21.10.81.6-0.4-1.31.3-0.51.2-1.0
Cocaine response after cond. corrected5.88.611.2-3.1-2.9-3.2-3.3-3.32.72.6-3.23.2-2.52.3
Cocaine response after cond. not corrected3.55.08.9-3.0-1.9-2.2-2.5-2.71.71.8-2.32.6-1.81.8
Cocaine response before conditioning4.04.86.11.52.42.32.52.0-2.2-2.22.4-2.32.2-2.0
Saline control response1.52.13.60.31.81.91.41.7-1.5-1.71.6-1.11.2-0.5
Bone: connectivity density0.71.22.51.01.31.31.11.3-1.6-0.91.0-1.10.4-0.0
Bone: cortical apparent density0.81.22.3-0.81.21.11.00.9-1.1-1.31.1-0.81.5-1.3
Bone: cortical area2.33.75.81.82.42.22.02.2-2.1-2.12.0-2.01.1-0.9
Bone: cortical porosity0.60.72.10.30.80.80.80.60.1-1.21.0-0.41.4-0.7
Bone: cortical porosity0.20.31.60.2-0.4-0.3-0.1-0.51.3-0.1-0.10.30.7-0.1
Bone: cortical thickness5.08.313.21.13.63.32.83.3-3.1-3.23.2-2.82.2-2.0
Bone: cortical thickness2.42.95.41.52.32.01.81.8-1.8-2.11.7-1.41.0-0.5
Bone: cortical tissue density0.60.91.8-1.01.00.90.80.6-0.9-1.10.8-0.61.3-1.1
Condit. Reinf. active minus inactive responses0.40.41.20.90.30.20.70.00.2-0.50.5-0.61.1-0.9
Condit. Reinf. active-inactive response ratio0.20.20.50.7-0.3-0.30.10.10.50.10.2-0.40.6-0.6
Condit. Reinf. active responses0.70.92.00.80.80.61.20.4-0.4-1.00.9-1.01.4-1.3
Condit. Reinf. inactive responses0.10.20.4-0.30.60.40.5-0.0-0.5-0.60.2-0.20.4-0.4
Incentive salience index mean1.11.43.01.50.80.61.30.7-0.2-1.11.1-1.31.7-1.5
Condit. Reinf. lever presses1.32.02.81.61.00.91.51.3-0.9-1.41.4-1.61.7-1.6
Condit. Reinf. active minus inactive responses0.20.20.7-0.4-0.3-0.4-0.60.10.00.7-0.40.4-0.80.5
Condit. Reinf. active-inactive response ratio0.30.51.3-1.1-0.6-0.7-0.8-0.60.40.8-0.60.6-0.70.4
Condit. Reinf. active responses0.20.31.01.00.50.50.50.9-0.4-0.20.5-0.5-0.0-0.0
Condit. Reinf. inactive responses1.82.65.42.31.61.71.81.7-0.9-1.61.7-1.61.4-1.0
Condit. Reinf. lever presses0.30.42.71.60.40.60.70.5-0.4-0.30.4-0.60.3-0.0
Condit. Reinf. lever reinforcers received0.10.10.60.80.10.20.10.6-0.20.20.1-0.1-0.50.5
Conditioned reinforcement - actives0.10.20.60.20.40.40.40.6-0.3-0.80.2-0.60.6-0.7
Conditioned reinforcement - inactives0.20.50.9-0.8-0.7-0.8-0.90.10.70.5-0.80.7-0.60.4
Conditioned locomotion0.10.10.30.1-0.3-0.20.0-0.30.3-0.1-0.2-0.40.5-0.6
Patch foraging indifference point 0 sec2.77.613.2-0.23.23.32.53.6-2.9-3.13.2-2.32.4-1.9
Patch foraging indifference point AUC1.33.05.91.81.92.12.21.3-2.4-1.71.6-1.61.1-0.6
Delay disc. indifference point, 0s delay0.80.96.52.60.3-0.10.60.50.9-0.60.0-0.80.4-0.6
Delay disc. indifference point, 16s delay0.10.21.21.1-0.1-0.3-0.00.30.8-0.1-0.4-0.3-0.10.0
Delay disc. indifference point, 2s delay0.30.30.80.90.80.40.30.60.2-0.70.00.20.10.6
Delay disc. indifference point, 24s delay0.20.31.00.40.70.60.61.0-0.0-0.50.5-0.40.6-0.3
Delay disc. indifference point, 4s delay0.10.20.70.4-0.0-0.3-0.3-0.00.8-0.2-0.50.3-0.30.5
Delay disc. indifference point, 8s delay0.30.41.81.3-0.3-0.5-0.2-0.31.40.1-0.70.1-0.10.3
Indifference point function ln k1.03.18.2-1.3-2.2-2.1-2.0-1.82.91.8-1.41.4-0.60.2
Indifference point function log k1.03.18.2-1.3-2.2-2.1-2.0-1.82.91.8-1.41.4-0.60.2
Patch foraging total patch changes 0 sec2.47.112.6-0.23.03.22.43.6-2.7-3.03.1-2.32.4-2.0
Patch foraging total patch changes 12 sec7.610.214.71.93.73.73.43.8-3.6-3.43.4-3.02.4-1.9
Patch foraging total patch changes 18 sec8.820.831.51.55.55.64.85.1-5.4-5.34.8-3.83.6-2.7
Patch foraging total patch changes 24 sec2.68.915.22.03.63.93.43.3-3.6-3.33.0-2.52.1-1.0
Patch foraging total patch changes 6 sec5.49.114.61.03.63.83.23.4-3.8-3.23.2-2.62.4-1.5
Patch foraging time to switch 0 sec0.10.41.4-1.2-0.2-0.4-0.6-0.40.10.4-0.61.0-0.70.7
Patch foraging water rate 0 sec0.83.03.91.21.71.91.91.4-1.7-2.01.7-1.91.8-1.5
Patch foraging water rate 12 sec0.10.51.00.80.60.60.50.8-0.3-1.00.7-1.00.5-0.7
Patch foraging water rate 18 sec0.30.82.10.6-1.4-1.2-0.8-0.81.40.8-0.70.0-0.2-0.1
Patch foraging water rate 24 sec0.10.20.6-0.6-0.5-0.3-0.3-0.80.40.1-0.30.4-0.10.1
Patch foraging water rate 6 sec0.81.22.00.61.31.31.01.1-0.8-1.41.2-1.11.0-0.7
Seeking ratio, delayed vs. immediate footshock0.81.12.00.5-1.4-1.4-1.2-0.71.01.1-1.30.3-1.30.5
Distance traveled before self-admin1.22.54.20.81.81.51.71.5-2.0-1.61.6-2.01.2-1.6
Distance traveled after self-admin1.42.43.9-0.61.71.81.51.6-2.0-1.71.5-1.31.7-1.4
Extensor digitorum longus weight0.00.20.60.6-0.1-0.10.10.8-0.3-0.00.2-0.70.1-0.4
Bone: elastic displacement3.24.17.1-0.42.42.72.11.6-2.4-2.42.2-1.52.1-1.4
Bone: elastic work4.15.39.40.52.93.12.61.7-2.6-2.82.5-1.92.1-1.4
Bone: endosteal estimation2.46.08.80.3-2.7-2.6-2.3-2.42.12.8-2.82.1-3.02.7
Bone: endosteal perimeter1.43.44.90.2-2.2-2.1-1.9-1.52.02.2-2.01.4-2.11.6
Epididymis fat weight0.52.84.50.1-2.0-2.1-2.0-1.11.91.9-1.81.0-2.01.0
Delta time in closed arm before/after self-admin4.94.66.70.9-2.2-2.5-2.4-1.72.62.1-2.31.7-2.52.1
Delta time in open arm before/after self-admin0.50.61.3-0.8-0.9-1.1-0.7-1.11.10.8-0.30.40.1-0.6
Diff in mean of infusions in LGA sessions0.10.10.4-0.40.30.40.1-0.1-0.40.1-0.00.5-0.30.6
Delay discount exponential model param0.20.21.2-1.1-0.3-0.1-0.2-0.4-0.60.40.20.10.0-0.3
Extinction: sum of active levers before priming0.91.46.41.10.60.41.10.10.8-1.30.8-1.02.5-1.6
Active lever presses in extinction session 61.01.02.6-0.3-1.0-1.0-0.7-1.61.60.9-1.01.10.10.4
Bone: final force1.32.23.51.71.91.81.61.5-1.8-1.61.4-1.20.6-0.0
Bone: final moment1.11.83.01.71.71.61.41.3-1.6-1.41.3-1.20.5-0.2
Food consumed during 24 hour testing period0.30.61.40.5-1.0-0.7-0.7-0.30.51.2-0.90.5-1.00.9
Glucose0.00.00.1-0.30.00.10.0-0.1-0.2-0.10.1-0.10.1-0.0
Heart weight0.81.21.91.31.21.21.20.9-1.4-1.10.9-1.40.8-0.5
Delay discount hyperbolic model param0.20.31.4-1.2-0.5-0.2-0.3-0.5-0.60.50.10.1-0.1-0.3
Intermittent access intake day 1-15 change0.10.42.5-1.60.20.3-0.50.5-0.60.2-0.00.6-0.50.5
Intermittent access intake escalation0.10.52.9-1.7-0.1-0.0-0.80.2-0.30.5-0.30.8-0.70.7
Intermittent access intake escalation 20.10.20.8-0.9-0.2-0.2-0.50.1-0.10.4-0.20.5-0.30.4
Intermitt. access day 1 inactive lever presses0.00.10.30.30.0-0.10.10.40.0-0.00.1-0.4-0.0-0.6
Intermitt. access day 15 inactive lever presses0.00.20.40.6-0.6-0.6-0.3-0.30.50.5-0.50.2-0.40.2
Intermitt. access escalation Index0.51.42.80.71.31.71.60.5-1.2-1.41.1-1.01.3-0.7
Intermittent access day 1 total infusions0.20.51.40.1-1.1-1.1-0.5-0.81.20.7-0.60.40.2-0.3
Intermittent access day 15 total infusions0.82.02.8-1.4-1.6-1.6-1.7-1.21.31.6-1.51.5-1.00.8
Intermittent access terminal intake (last 3 days)0.71.11.9-1.3-1.4-1.3-1.3-0.60.81.3-1.01.1-0.60.4
Intermittent access total infusions1.82.14.1-1.3-2.0-1.9-1.6-1.61.61.5-1.51.3-0.60.3
Intermittent access day 1 locomotion0.30.50.9-0.7-0.9-0.8-0.6-0.90.70.7-0.70.6-0.30.1
Intermittent access day 15 total locomotion0.31.11.8-1.2-1.3-1.1-1.3-0.60.91.1-1.11.1-0.80.8
Intermittent access total locomotion0.70.94.7-2.2-0.7-0.5-1.0-0.80.30.6-0.71.1-0.40.5
Intermittent access standard deviation0.10.51.40.0-1.1-1.2-0.8-0.50.70.6-0.5-0.2-0.4-0.6
Left kidney weight0.11.15.92.40.70.70.90.9-0.6-0.90.7-1.30.4-0.2
Right kidney weight0.10.53.92.00.20.10.40.5-0.0-0.30.2-0.80.00.1
Cocaine induced anxiety0.61.73.30.11.81.71.41.3-1.8-1.21.2-1.11.0-0.6
Post-drug Anxiety2.22.54.71.22.01.91.72.2-2.2-1.21.2-1.40.9-0.5
Baseline Anxiety0.40.72.01.40.60.70.71.3-0.9-0.40.8-0.80.4-0.3
Tail length0.00.31.2-0.2-0.20.0-0.2-0.70.10.3-0.30.7-0.61.1
Length with tail0.10.31.80.40.20.3-0.20.30.20.1-0.10.6-0.71.4
Length without tail0.10.73.00.1-0.1-0.2-0.90.20.60.6-0.71.1-1.31.7
Times rat made contact with spout1.21.45.22.30.70.71.30.9-0.2-0.91.0-1.31.4-1.1
Lifetime Intake1.62.04.3-1.2-2.1-1.9-1.5-1.61.51.5-1.41.2-0.50.1
Liver weight, left1.01.74.12.0-1.7-1.8-1.0-0.71.91.3-1.2-0.1-0.80.3
Liver weight, right1.22.23.1-0.7-1.7-1.7-1.7-1.41.81.4-1.61.3-1.41.1
Locomotor activity3.04.610.11.32.02.01.83.2-2.2-2.02.5-2.71.5-1.9
Locomotor testing distance2.86.99.91.02.32.52.62.8-2.4-2.53.0-3.13.0-2.9
Locomotor testing rearing1.45.38.31.11.82.02.42.1-2.2-2.22.5-2.92.6-2.8
Locomotion in novel chamber0.91.22.80.61.61.71.21.2-1.2-1.31.0-0.40.40.3
Locomotion in novel chamber post-restriction0.30.91.70.71.21.20.81.0-1.0-0.91.3-1.10.3-0.4
Fecal boli incidents, locomotor time 10.30.83.1-1.80.0-0.3-1.20.1-0.20.3-0.40.9-1.11.1
Change in fecal boli incidents, locomotor task0.30.41.4-0.1-0.8-0.5-0.2-1.20.90.5-0.70.30.1-0.0
Time >=10cm from walls, locomotor time 10.50.62.2-1.50.80.5-0.31.1-1.2-0.30.3-0.1-0.80.1
Bouts of movement, locomotor time 10.91.14.6-2.10.10.1-0.7-0.6-0.20.3-0.71.5-1.11.6
Total resting periods, locomotor time 11.21.45.9-2.40.20.3-0.6-0.7-0.50.3-0.61.6-1.21.8
Rest time, locomotor task time 10.71.15.3-2.3-0.10.1-0.6-1.1-0.50.2-0.61.3-1.11.4
Distance moved, locomotor task time 11.44.06.52.41.41.21.92.3-0.8-1.91.9-2.52.3-2.5
Vertical activity count, locomotor time 10.53.36.02.40.90.81.72.1-0.6-1.61.7-2.32.2-2.4
Time >=10cm from walls, locomotor time 20.20.53.9-2.00.30.4-0.10.5-0.9-0.00.30.2-0.1-0.3
Bouts of movement, locomotor time 20.10.31.4-1.20.70.5-0.10.8-0.2-0.50.40.30.20.3
Total resting periods, locomotor time 20.10.40.9-0.81.00.80.20.9-0.6-0.80.6-0.00.40.1
Rest time, locomotor task time 20.20.30.9-0.90.50.70.2-0.2-1.0-0.60.20.3-0.10.7
Distance moved, locomotor task time 20.40.51.20.20.70.70.71.1-0.7-0.60.8-0.70.4-0.6
Vertical activity count, locomotor time 20.51.32.90.60.80.70.91.7-0.8-1.01.3-1.41.2-1.5
Light reinforcement 10.73.14.41.31.72.01.92.0-2.0-1.31.9-2.11.5-1.2
Light reinforcement 20.20.41.4-0.7-0.7-0.6-0.6-0.80.11.2-0.40.2-0.40.1
Bone: marrow area2.56.08.90.3-2.7-2.6-2.4-2.42.12.8-2.82.1-3.02.7
Bone: maximum diameter0.30.73.51.90.50.60.80.9-0.3-0.60.7-1.00.3-0.3
Bone: maximum force0.91.72.81.71.61.51.31.4-1.6-1.31.2-1.20.4-0.1
Bone: maximum moment0.71.32.91.71.31.21.11.1-1.3-1.11.0-1.20.2-0.2
Mean time between licks in bursts0.00.21.21.1-0.3-0.20.10.10.5-0.1-0.1-0.30.1-0.1
Mean num. licks in bursts0.10.21.20.4-0.3-0.4-0.4-0.21.10.1-0.30.5-0.20.4
Cd content in liver1.82.06.8-2.6-0.8-0.5-1.7-0.5-0.31.2-0.91.4-1.91.6
Co content in liver0.20.30.90.7-0.10.00.20.9-0.50.10.6-0.70.2-0.6
Cu content in liver2.02.47.6-0.31.81.71.02.8-1.8-1.51.9-1.00.8-0.9
Fe content in liver0.50.64.32.10.50.30.90.1-0.2-0.50.3-0.60.5-0.1
K content in liver0.10.10.50.1-0.1-0.1-0.00.70.00.10.3-0.10.2-0.3
Mg content in liver0.50.62.3-0.10.50.70.51.5-0.7-0.61.0-0.60.6-0.6
Mn content in liver0.50.51.30.1-0.8-0.9-1.0-0.00.40.8-0.70.4-1.10.8
Na content in liver1.01.16.12.50.90.51.01.1-0.2-0.90.7-0.90.6-0.2
Rb content in liver0.30.41.2-1.1-0.9-0.4-0.5-0.50.30.7-0.50.8-0.20.3
Se content in liver0.40.41.0-0.4-0.7-0.8-1.00.21.00.5-0.30.6-0.70.5
Sr content in liver0.20.10.30.2-0.6-0.4-0.4-0.20.30.6-0.4-0.0-0.30.2
Zn content in liver0.20.31.9-0.4-0.00.3-0.11.4-0.60.20.6-0.4-0.2-0.1
Bone: minimum diameter0.71.43.50.1-0.9-0.9-1.1-0.90.61.3-1.21.1-1.91.8
Time in familiar zone, hab. session 12.32.64.20.71.91.91.52.1-1.8-1.81.8-1.51.1-0.9
Time in novel zone, hab. session 10.30.32.1-1.5-0.2-0.2-0.4-0.60.30.2-0.40.60.1-0.1
Total zone transitions, hab. session 11.11.63.92.01.31.11.60.7-0.4-1.41.2-1.21.4-1.0
Total locomotion distance, hab. session 10.60.84.52.10.80.71.2-0.00.0-0.70.6-0.60.8-0.3
Locomotion velocity, hab. session 10.71.07.32.70.60.41.2-0.30.4-0.50.4-0.70.8-0.2
Time in familiar zone, hab. session 21.21.32.7-0.71.51.51.10.8-1.6-1.41.2-0.61.0-0.6
Time in novel zone, hab. session 20.50.51.0-0.2-0.9-0.9-0.8-0.71.00.8-0.80.5-0.50.3
Total zone transitions, hab. session 20.10.20.50.3-0.3-0.6-0.1-0.60.70.2-0.30.00.3-0.3
Total locomotion distance, hab. session 20.10.10.60.70.1-0.10.2-0.10.4-0.20.1-0.20.4-0.2
Locomotion velocity, hab. session 20.10.21.41.20.0-0.20.3-0.10.5-0.20.0-0.20.4-0.2
Novel to familiar place preference ratio3.74.88.5-2.9-2.1-2.0-2.2-2.51.42.2-2.32.6-1.91.6
Novelty place preference3.64.67.3-2.7-2.0-1.9-2.1-2.51.42.1-2.32.5-2.01.6
Time in novel zone, NPP test2.93.67.2-2.7-1.7-1.6-1.8-2.31.11.8-2.02.2-1.61.3
Total zone transitions, NPP test2.63.85.81.81.91.72.11.6-0.9-2.12.1-2.12.4-2.2
Total locomotion distance, NPP test1.31.82.81.31.61.51.70.9-0.7-1.51.4-1.21.7-1.1
Locomotion velocity, NPP test0.60.81.41.21.11.01.20.5-0.3-1.00.9-0.61.0-0.4
Intraocular pressure0.91.43.00.2-1.0-1.3-1.2-0.90.81.3-1.60.9-1.71.4
Delta distance traveled before/after self-admin1.01.15.2-2.3-0.5-0.2-0.8-0.90.30.7-0.91.7-0.31.1
Delta ambulatory time before/after self-admin1.62.86.5-2.5-1.5-1.2-1.8-1.51.01.6-1.72.2-1.11.5
Parametrial fat weight0.40.92.70.3-1.3-1.2-0.7-1.11.61.0-0.80.60.10.1
Pavlov. Cond. lever latency0.50.65.4-2.30.40.5-0.2-0.2-0.4-0.10.10.60.10.1
Pavlov. Cond. magazine entry latency0.50.65.72.4-0.4-0.50.2-0.10.70.3-0.3-0.20.10.3
Pavlov. Cond. change in total contacts0.50.52.31.5-0.6-0.7-0.3-0.40.80.5-0.60.5-0.60.9
Pavlov. Cond. index score0.70.98.93.0-0.2-0.30.60.20.3-0.00.1-0.80.3-0.1
Pavlov. Cond. latency score0.60.77.22.7-0.4-0.50.30.10.50.1-0.1-0.5-0.00.1
Pavlov. Cond. lever contacts0.70.87.12.7-0.2-0.30.50.30.6-0.20.2-0.70.4-0.4
Pavlov. Cond. magazine entry number0.70.98.7-3.00.20.1-0.5-0.1-0.3-0.10.10.4-0.1-0.5
Pavlov. Cond. intertrial magazine entries1.92.24.7-1.51.51.41.30.5-0.6-1.81.6-1.02.1-2.2
Pavlov. Cond. lever-magazine prob. diff.0.70.98.02.8-0.2-0.30.60.20.3-0.00.1-0.80.4-0.2
Pavlov. Cond. response bias1.11.412.63.5-0.0-0.01.00.20.2-0.20.3-1.00.6-0.2
Pavlov. Cond. lever latency1.01.42.4-0.2-1.4-1.5-1.2-1.51.31.2-1.40.8-1.10.7
Pavlov. Cond. magazine entry latency0.40.51.1-0.6-0.9-0.7-0.6-0.81.10.7-0.60.9-0.20.4
Pavlov. Cond. change in total contacts0.10.31.2-0.5-0.2-0.0-0.4-0.2-0.20.6-0.40.7-0.71.1
Pavlov. Cond. index score0.10.10.3-0.20.40.50.30.5-0.4-0.20.40.10.20.2
Pavlov. Cond. latency score0.10.10.5-0.70.10.3-0.10.2-0.30.00.10.5-0.10.5
Pavlov. Cond. lever contacts1.11.62.40.61.41.61.41.5-1.2-1.31.4-1.01.3-0.8
Pavlov. Cond. magazine entry number0.00.00.1-0.10.10.1-0.1-0.2-0.3-0.1-0.10.0-0.20.1
Pavlov. Cond. intertrial magazine entries0.20.40.60.00.60.60.50.7-0.8-0.60.6-0.80.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.40.30.50.10.4-0.5-0.10.30.20.00.4
Pavlov. Cond. response bias0.50.81.20.80.91.01.01.1-0.6-0.81.0-0.70.9-0.5
Time in closed arm before self-admin2.54.36.9-0.22.12.32.32.3-2.6-1.92.2-1.82.3-1.8
Time in closed arm after self-admin0.40.50.8-0.1-0.5-0.4-0.5-0.60.50.7-0.90.8-0.90.9
Time in open arm before self-admin2.83.47.40.7-1.6-1.5-1.8-1.61.51.9-2.01.8-2.52.7
Time in open arm after self-admin0.40.41.0-0.3-0.9-0.9-0.5-0.91.00.8-0.10.10.3-0.5
Bone: periosteal estimation0.30.61.81.3-0.4-0.4-0.4-0.30.20.7-0.70.3-1.41.3
Bone: periosteal perimeter0.10.20.90.7-0.0-0.1-0.20.4-0.20.3-0.1-0.2-1.00.6
Bone: post-yield work0.91.53.10.3-1.6-1.8-1.3-1.01.51.3-1.40.7-1.10.6
Progressive ratio test 1 active lever presses0.81.52.5-0.5-1.6-1.4-1.3-1.31.51.3-1.31.2-0.80.7
Progressive ratio test 1 breakpoint0.81.32.2-0.5-1.5-1.3-1.2-1.31.31.2-1.31.1-0.80.7
Progressive ratio test 1 inactive lever presses0.00.10.4-0.6-0.3-0.4-0.4-0.30.20.1-0.30.2-0.4-0.1
Progressive ratio test 2 active lever presses0.30.41.0-1.0-0.9-0.6-0.7-0.70.50.5-0.70.7-0.10.2
Progressive ratio test 2 breakpoint0.30.41.1-1.1-0.9-0.6-0.7-0.60.50.5-0.70.7-0.20.3
Progressive ratio test 2 inactive lever presses0.00.10.5-0.6-0.4-0.3-0.50.70.10.2-0.30.2-0.3-0.1
Incentive Sensitization - Responses0.10.21.4-1.2-0.4-0.1-0.2-0.20.20.0-0.20.60.40.1
Incentive Sensitization - Breakpoint0.10.21.6-1.3-0.3-0.0-0.2-0.10.1-0.0-0.20.60.50.1
Sum of active levers in priming session hrs 5-60.20.20.4-0.10.40.50.3-0.40.3-0.40.00.50.60.5
Progressive ratio0.10.20.60.60.60.40.40.8-0.7-0.10.3-0.1-0.20.4
Food seeking constrained by brief footshock0.60.71.8-0.20.70.80.81.3-0.9-0.80.9-0.70.9-0.7
Seeking ratio, punishment vs. effort0.10.20.6-0.6-0.4-0.1-0.0-0.10.3-0.20.1-0.20.7-0.8
Retroperitoneal fat weight0.21.11.8-0.5-1.0-1.1-1.2-1.00.61.3-1.20.8-1.31.0
Reaction time number correct0.20.61.90.40.30.50.80.4-0.0-0.40.7-0.81.4-1.3
Reaction time mean minus median0.00.31.0-1.0-0.2-0.3-0.6-0.3-0.30.2-0.50.5-0.60.6
Reaction time mean minus median AUC0.10.82.0-1.4-0.1-0.1-0.8-0.2-0.90.4-0.70.9-1.31.4
Reaction time num false alarms0.61.02.61.40.20.30.80.60.2-0.50.8-1.41.6-1.6
Reaction time num false alarms AUC0.30.72.21.30.00.00.60.20.5-0.20.5-1.21.4-1.5
Reaction time trials correct on left0.20.61.90.40.30.50.80.4-0.0-0.40.7-0.81.4-1.3
Reaction time trials on left0.10.51.80.40.20.40.80.30.0-0.40.7-0.71.3-1.3
Reaction time mean1.22.64.2-1.7-1.6-1.7-2.0-1.21.21.7-1.81.6-1.81.3
Reaction time mean AUC1.74.26.1-1.8-2.1-2.2-2.5-1.71.72.2-2.22.0-2.11.7
Median of all reaction times2.84.46.4-1.5-2.3-2.4-2.5-1.82.02.3-2.32.0-2.11.5
Reaction time omissions1.11.82.8-0.8-1.4-1.7-1.7-1.41.61.5-1.31.1-1.20.8
Reaction time false alarm rate0.10.20.50.6-0.4-0.5-0.2-0.20.70.3-0.1-0.40.3-0.5
Reaction time premature initiation rate1.52.33.5-0.91.61.91.51.3-1.3-1.71.8-1.01.9-1.5
Reaction time premature initiations1.13.35.9-0.61.72.21.91.5-1.4-1.92.2-1.42.4-2.0
Std. dev. reaction times0.10.31.6-1.3-0.3-0.3-0.7-0.2-0.30.3-0.50.6-0.70.6
Reaction time trials completed0.10.51.80.40.20.40.80.30.0-0.40.7-0.71.3-1.3
Reaction time trials AUC0.20.72.10.70.30.50.90.6-0.1-0.50.8-1.01.5-1.4
Run reversals in cocaine runway, females1.41.62.5-0.51.41.21.01.2-1.6-1.61.3-1.40.7-1.3
Run reversals in cocaine runway, males1.41.52.4-0.2-1.5-1.3-1.1-1.40.81.5-1.61.1-1.11.2
Latency to leave start box in cocaine runway0.40.54.32.10.1-0.20.40.20.8-0.10.0-0.30.3-0.0
Latency to leave start box in cocaine runway, F0.30.33.11.80.0-0.10.30.20.50.1-0.10.00.10.5
Latency to leave start box in cocaine runway, M0.30.31.31.1-0.0-0.40.2-0.00.8-0.20.1-0.40.4-0.7
Std. dev. time between licks in bursts1.93.56.90.82.32.31.92.2-2.6-2.01.9-1.70.9-0.8
Total sessions with >9 infusions0.60.81.6-0.7-1.3-1.1-1.0-0.80.80.9-0.90.9-0.70.4
Short access day 1 total inactive lever presses0.10.31.0-0.0-0.6-0.7-0.2-0.80.60.3-0.4-0.40.3-1.0
Short access day 10 total inactive lever presses0.00.10.40.30.1-0.2-0.20.30.1-0.00.1-0.7-0.5-0.6
Short access day 1 total infusions0.81.63.60.1-1.9-1.7-1.1-1.51.71.5-1.30.9-0.60.2
Short access day 10 total infusions3.25.29.8-0.8-3.1-2.9-2.3-2.72.72.5-2.32.1-1.30.9
Short access total infusions1.62.35.5-0.5-2.4-2.0-1.4-1.81.81.7-1.41.2-0.60.2
Short access day 1 locomotion0.10.20.7-0.80.40.4-0.1-0.2-0.5-0.20.10.4-0.40.3
Short access day 10 total locomotion0.41.62.8-1.4-1.7-1.4-1.3-1.51.11.4-1.41.2-0.80.7
Short access total locomotion1.11.62.5-1.6-1.6-1.2-1.4-1.50.91.2-1.21.3-1.10.7
One hour access (0.3 mA shock)0.30.30.8-0.8-0.9-0.7-0.5-0.00.50.4-0.2-0.10.4-0.9
Compulsive drug intake0.10.20.50.20.70.70.50.4-0.5-0.50.4-0.20.20.2
One hour access (shock baseline)0.20.41.2-0.3-1.1-1.0-0.7-0.30.70.8-0.50.1-0.0-0.6
Social response proportion0.40.52.0-1.40.00.0-0.7-0.1-0.10.0-0.31.0-0.71.0
Social responses1.51.93.9-0.21.51.81.22.0-1.7-1.51.5-1.01.1-0.7
Social time0.60.92.0-1.0-1.4-1.1-1.1-0.81.30.9-0.60.8-0.30.3
Soleus weight0.31.08.52.9-0.4-0.40.60.00.30.1-0.0-1.20.3-0.6
Bone: stiffness0.50.95.52.3-0.4-0.7-0.40.30.70.6-0.6-0.0-1.21.0
Tibialis anterior weight0.10.41.71.30.1-0.00.30.8-0.2-0.20.4-1.00.1-0.6
Time to tail flick, vehicle, before self-admin0.50.61.30.5-1.0-1.1-0.6-1.00.71.0-0.50.2-0.5-0.1
Time to tail flick, vehicle, after self-admin1.12.24.4-1.2-1.0-0.7-1.3-1.70.81.4-1.62.0-1.82.1
Time to tail flick, test, before self-admin1.72.03.50.21.51.21.41.2-1.1-1.51.6-1.41.7-1.9
Time to tail flick, test, after self-admin0.60.64.62.1-0.5-0.50.3-0.31.10.3-0.1-0.40.2-0.3
Delta time to tail flick, vehicle, before/after SA1.11.22.5-0.8-0.7-0.5-1.0-1.01.20.7-1.31.6-1.01.6
Delta time to tail flick, test, before/after SA1.21.52.51.5-1.6-1.5-1.0-0.71.61.5-1.10.5-1.21.0
Tibia length0.41.24.61.2-0.5-0.5-0.6-1.10.70.7-1.11.0-1.52.1
Ambulatory time before self-admin1.23.85.21.02.21.92.21.5-2.2-2.22.1-2.31.7-1.8
Ambulatory time after self-admin0.91.53.2-1.81.21.10.90.9-1.5-1.31.0-0.71.4-1.1
Bone: tissue strength0.90.91.5-0.7-1.0-1.0-1.2-1.01.01.0-1.00.9-1.00.7
Total heroin consumption0.91.14.42.10.30.21.00.90.5-0.70.4-1.11.4-1.2
Bone: trabecular number0.61.11.91.21.31.21.11.4-1.3-1.00.9-1.10.4-0.2
Bone: trabecular spacing0.40.51.2-0.1-1.1-1.0-0.6-1.01.00.7-0.60.3-0.1-0.1
Bone: trabecular thickness1.62.33.41.81.81.71.61.8-1.6-1.41.5-1.50.7-0.6
Bone: trabecular tissue density0.50.81.40.50.90.80.91.0-0.6-1.11.0-1.00.9-1.2
Water consumed over 24 hours0.40.94.22.00.30.20.90.4-0.0-0.50.5-1.31.1-1.1
Number of responses in last shaping day0.50.61.10.2-1.0-1.0-1.0-0.51.00.9-0.80.4-0.90.3