Sdhaf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sdhaf1	0.02	0.02	2.0e-03	0.02	0.02	0.02	0.02	9.1e-04	6.4e-03	2.1e-03	1.4e-03
2	PL	gene expression	Sdhaf1	0.1	0.05	3.7e-11	0.06	0.1	0.1	0.09	3.8e-07	1.0e-10	1.1e-10	4.6e-10
3	Adipose	gene expression	Sdhaf1	0.38	0.15	0.0e+00	0.31	0.31	0.31	0.31	3.2e-35	5.6e-35	4.5e-35	2.2e-35
4	Brain	gene expression	Sdhaf1	0.04	0.03	1.5e-04	0.05	0.04	0.05	0.05	8.8e-06	3.3e-04	1.7e-05	3.6e-05
5	BLA	gene expression	Sdhaf1	0.05	0.04	4.2e-03	0.03	0.01	0.02	0.02	1.2e-02	1.1e-01	4.0e-02	3.9e-02
6	OFC	gene expression	Sdhaf1	0.3	0.17	3.0e-04	0.06	0.06	0.06	0.06	1.7e-02	2.0e-02	1.3e-02	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.6	1.0	2.7	-1.1	0.5	0.8	-1.0	-0.8	-1.6
Area under the delay curve	0.5	0.5	0.8	-0.6	0.9	0.7	-0.6	-0.8	0.7
BMI with tail	0.2	0.8	1.1	0.6	-0.6	-1.0	0.9	1.0	1.0
BMI without tail	0.1	0.1	0.4	-0.6	0.1	0.3	-0.2	-0.2	-0.2
Body weight	2.4	10.2	12.4	-3.5	2.9	3.2	-3.2	-2.9	-3.3
Weight adjusted by age	0.1	0.2	0.3	0.1	0.2	-0.1	-0.5	0.6	-0.6
Bone surface	1.5	2.6	3.3	-1.8	1.7	1.6	-1.6	-1.7	-1.2
Bone volume	1.4	2.3	2.7	-1.6	1.5	1.4	-1.5	-1.5	-1.5
Breakpoint value in progressive ratio session	1.9	2.1	4.0	-1.4	1.6	1.7	-1.0	-2.0	0.2
Number of licking bursts	3.7	4.4	5.2	2.2	-1.4	-2.2	2.1	2.3	2.3
Context. condit. distance diff. score	0.1	0.1	0.6	0.2	0.4	-0.2	0.2	0.1	0.7
Locomotion velocity, session 1	0.6	0.7	1.4	0.8	-1.2	-0.8	1.0	0.7	-0.3
Locomotion distance, session 1	0.4	0.5	1.0	-0.9	1.0	0.8	-0.5	-0.8	-0.3
Locomotion velocity, session 2	0.4	0.5	0.8	0.5	-0.9	-0.6	0.8	0.5	0.6
Locomotion distance, session 2	1.3	1.8	3.2	1.2	-0.9	-1.3	1.5	1.3	1.8
Locomotion velocity, session 3	0.3	0.3	0.5	0.7	-0.5	-0.6	0.5	0.7	0.5
Locomotion distance, session 3	2.9	3.2	5.9	-1.6	2.4	1.8	-1.9	-1.8	0.2
Stereotopy head waving bouts, day 3	0.7	0.9	2.4	0.7	-1.6	-0.8	0.8	0.8	-0.5
Stereotopy head waving duration, day 3	1.5	1.8	4.0	1.2	-2.0	-1.3	1.3	1.3	-0.1
Locomotion velocity, session 7	0.3	0.4	0.9	-0.7	0.9	0.6	-0.5	-0.5	0.2
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	0.5	0.3	-0.3	-0.3	-0.4
Stereotopy head waving bouts, day 7	1.1	1.3	2.2	1.1	-0.7	-1.0	1.2	1.1	1.5
Stereotopy head waving duration, day 7	2.3	2.8	3.3	1.6	-1.6	-1.7	1.8	1.7	1.6
Locomotion velocity, session 8	3.8	4.5	6.0	2.1	-1.6	-2.2	2.2	2.1	2.5
Locomotion distance, session 8	1.0	1.4	4.0	1.0	-0.2	-1.1	1.1	1.0	2.0
Degree of sensitization distance	0.7	0.7	1.3	0.7	-1.1	-0.8	0.9	0.8	-0.6
Degree of sensitization stereotypy	1.5	1.6	3.4	1.2	-0.6	-1.2	1.3	1.2	1.8
Conditioned locomotion	0.6	0.7	1.2	0.9	-0.7	-0.7	1.0	0.6	1.1
Cocaine response after cond. corrected	0.2	0.2	0.7	0.2	-0.8	-0.2	0.1	0.2	-0.7
Cocaine response after cond. not corrected	0.3	0.3	1.3	-0.0	-0.9	-0.0	-0.1	0.0	-1.2
Cocaine response before conditioning	1.3	1.5	1.7	-1.3	1.1	1.2	-1.3	-1.3	-1.2
Saline control response	0.0	0.1	0.2	-0.2	-0.2	0.2	0.1	-0.2	-0.4
Bone: connectivity density	0.3	0.4	0.7	-0.8	0.5	0.5	-0.7	-0.6	-0.6
Bone: cortical apparent density	2.1	2.8	3.7	1.9	-1.3	-1.7	1.8	1.7	1.5
Bone: cortical area	1.3	1.9	2.1	-1.4	1.2	1.4	-1.5	-1.4	-1.4
Bone: cortical porosity	1.5	1.6	4.1	1.1	-0.7	-1.2	1.0	1.2	2.0
Bone: cortical porosity	2.1	2.2	5.3	1.3	-0.8	-1.5	1.3	1.4	2.3
Bone: cortical thickness	0.3	0.4	1.1	-0.6	0.3	0.6	-0.7	-0.7	-1.0
Bone: cortical thickness	0.7	0.9	1.5	0.9	-1.2	-0.9	0.9	1.0	0.0
Bone: cortical tissue density	2.4	3.2	4.1	2.0	-1.4	-1.9	1.9	1.8	1.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.4	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.4	-0.9	-0.4	0.3	0.4	-0.2
Condit. Reinf. active responses	2.1	2.6	3.4	1.6	-1.4	-1.6	1.8	1.4	1.8
Condit. Reinf. inactive responses	2.4	2.9	5.7	1.7	-1.0	-1.5	1.9	1.4	2.4
Incentive salience index mean	0.2	0.2	0.6	0.4	-0.3	-0.4	0.4	0.3	0.8
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.2	0.3	0.2	-0.1	-0.3	0.8
Condit. Reinf. active minus inactive responses	1.6	2.0	2.7	-1.6	1.3	1.6	-1.5	-1.6	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	0.2	0.1
Condit. Reinf. active responses	3.7	5.1	6.3	-2.5	2.3	2.4	-2.4	-2.5	-1.2
Condit. Reinf. inactive responses	4.7	5.8	7.8	-2.7	2.8	2.5	-2.5	-2.5	-0.8
Condit. Reinf. lever presses	7.4	10.1	11.9	-3.4	2.9	3.4	-3.3	-3.4	-2.5
Condit. Reinf. lever reinforcers received	3.8	5.3	6.4	-2.5	2.5	2.5	-2.4	-2.5	-1.1
Conditioned reinforcement - actives	0.2	0.2	0.4	0.5	-0.4	-0.6	0.4	0.4	0.3
Conditioned reinforcement - inactives	1.1	1.2	2.6	-0.9	1.6	0.8	-0.7	-0.8	1.4
Conditioned locomotion	2.4	2.8	5.1	1.6	-1.1	-1.6	1.7	1.6	2.2
Patch foraging indifference point 0 sec	0.2	0.2	0.5	-0.5	0.5	0.3	-0.7	-0.5	0.2
Patch foraging indifference point AUC	0.3	0.3	0.7	0.5	-0.8	-0.7	0.6	0.4	0.3
Delay disc. indifference point, 0s delay	0.5	0.5	1.7	-0.3	0.9	0.3	0.2	-0.7	1.3
Delay disc. indifference point, 16s delay	1.2	1.2	1.9	-0.6	1.3	1.2	-1.0	-1.4	0.7
Delay disc. indifference point, 2s delay	0.9	1.0	2.0	-1.1	1.4	1.1	-0.8	-0.9	0.1
Delay disc. indifference point, 24s delay	2.4	2.4	3.6	-1.6	1.9	1.7	-1.7	-1.5	-0.2
Delay disc. indifference point, 4s delay	0.2	0.2	1.2	0.1	0.2	-0.2	0.2	0.0	1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.6	0.6	0.4	-0.6	-0.4	0.0
Indifference point function ln k	0.3	0.5	0.7	-0.5	0.7	0.8	-0.6	-0.8	-0.6
Indifference point function log k	0.3	0.5	0.7	-0.5	0.7	0.8	-0.6	-0.8	-0.6
Patch foraging total patch changes 0 sec	0.3	0.4	0.7	-0.7	0.7	0.5	-0.9	-0.7	0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.2	-0.5	0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.1	0.2	0.4
Patch foraging total patch changes 24 sec	0.8	0.9	1.9	-1.0	1.4	0.8	-1.1	-0.9	-0.1
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	-0.5	0.1	0.1	-0.5	-0.0	0.1
Patch foraging time to switch 0 sec	0.5	0.7	1.3	0.9	-1.2	-0.9	0.8	0.7	0.3
Patch foraging water rate 0 sec	0.6	0.9	1.3	0.7	-0.7	-0.9	1.0	1.1	1.1
Patch foraging water rate 12 sec	0.4	0.6	1.4	-0.7	1.2	0.8	-0.9	-0.3	-0.4
Patch foraging water rate 18 sec	0.1	0.2	0.5	0.2	-0.4	-0.2	0.3	0.7	0.4
Patch foraging water rate 24 sec	0.3	0.5	1.9	0.0	0.9	0.0	0.1	0.4	1.4
Patch foraging water rate 6 sec	1.0	1.4	3.3	-1.3	1.8	1.2	-1.2	-0.7	-0.0
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.8	-0.6	1.7	0.8	-1.1	-1.2	0.0
Distance traveled before self-admin	0.1	0.1	0.3	-0.2	-0.1	0.2	0.2	-0.5	-0.2
Distance traveled after self-admin	4.0	4.5	5.5	-2.3	2.2	2.4	-2.1	-2.3	-1.2
Extensor digitorum longus weight	0.2	0.8	1.6	0.8	-1.3	-0.9	0.9	1.0	-0.6
Bone: elastic displacement	0.1	0.1	0.4	0.2	-0.3	-0.1	-0.0	-0.0	-0.6
Bone: elastic work	1.7	2.3	2.7	-1.5	1.2	1.5	-1.5	-1.6	-1.6
Bone: endosteal estimation	1.7	3.6	4.6	-2.1	1.9	2.0	-1.9	-2.0	-1.3
Bone: endosteal perimeter	1.5	3.0	3.8	-1.8	2.0	1.9	-1.7	-1.9	-0.9
Epididymis fat weight	0.0	0.1	0.3	-0.3	0.5	0.2	-0.3	0.0	-0.4
Delta time in closed arm before/after self-admin	2.4	2.3	2.6	-1.5	1.4	1.6	-1.6	-1.4	-1.6
Delta time in open arm before/after self-admin	0.7	0.7	1.9	0.4	-0.9	-0.9	0.5	1.4	0.3
Diff in mean of infusions in LGA sessions	0.5	0.6	2.3	0.2	-0.2	-0.3	1.0	-0.0	1.5
Delay discount exponential model param	0.5	0.6	0.9	0.7	-1.0	-0.8	0.8	0.8	-0.4
Extinction: sum of active levers before priming	3.6	3.6	4.4	-1.8	1.6	2.1	-1.8	-2.1	-1.9
Active lever presses in extinction session 6	3.5	3.4	6.5	-1.7	0.8	2.0	-1.4	-2.1	-2.5
Bone: final force	1.6	2.5	3.0	-1.7	1.6	1.6	-1.7	-1.6	-1.1
Bone: final moment	2.0	3.3	3.7	-1.9	1.8	1.9	-1.9	-1.9	-1.4
Food consumed during 24 hour testing period	0.8	1.0	2.0	-1.0	1.4	1.0	-1.0	-1.0	0.2
Glucose	0.3	0.4	0.7	0.5	-0.9	-0.5	0.7	0.5	-0.6
Heart weight	0.2	0.3	0.7	-0.1	0.8	0.7	-0.4	-0.6	0.3
Delay discount hyperbolic model param	0.4	0.4	0.8	0.6	-0.9	-0.7	0.6	0.6	-0.5
Intermittent access intake day 1-15 change	1.9	1.9	2.6	-1.5	1.6	1.2	-1.6	-0.9	-1.3
Intermittent access intake escalation	1.8	1.8	2.7	-1.4	1.6	1.2	-1.6	-0.8	-1.1
Intermittent access intake escalation 2	1.6	1.5	1.9	-1.3	1.2	1.1	-1.4	-1.3	-1.2
Intermitt. access day 1 inactive lever presses	3.8	4.1	5.2	-2.2	2.1	2.2	-2.3	-2.1	-0.8
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.3	-0.6	1.1	0.8	-0.9	-0.6	0.8
Intermitt. access escalation Index	0.2	0.2	0.6	0.4	0.1	-0.2	0.5	0.1	0.8
Intermittent access day 1 total infusions	2.7	3.1	6.2	1.8	-0.8	-1.7	1.8	1.5	2.5
Intermittent access day 15 total infusions	0.5	0.6	2.3	0.5	0.7	-0.4	0.2	0.3	1.5
Intermittent access terminal intake (last 3 days)	0.8	0.8	3.3	0.7	0.3	-0.7	0.6	0.5	1.8
Intermittent access total infusions	1.1	1.2	3.8	1.1	0.1	-0.9	0.9	0.7	1.9
Intermittent access day 1 locomotion	1.5	1.6	6.0	1.0	-0.1	-0.9	1.2	0.6	2.5
Intermittent access day 15 total locomotion	0.5	0.5	2.2	0.1	0.8	-0.2	0.1	0.2	1.5
Intermittent access total locomotion	1.4	1.6	4.6	1.1	-0.4	-1.1	1.2	0.9	2.1
Intermittent access standard deviation	4.9	5.2	7.9	-2.3	2.8	2.3	-2.5	-2.4	-1.0
Left kidney weight	2.6	7.2	13.5	-2.5	2.0	2.5	-2.9	-2.2	-3.7
Right kidney weight	4.7	13.2	18.8	-3.6	3.0	3.6	-3.9	-3.3	-4.3
Cocaine induced anxiety	0.5	0.6	0.8	-0.9	0.5	0.8	-0.7	-0.8	-0.7
Post-drug Anxiety	0.0	0.0	0.1	0.2	-0.4	-0.1	0.0	-0.1	0.2
Baseline Anxiety	1.3	1.4	2.2	1.3	-0.9	-1.2	0.9	1.1	1.5
Tail length	4.7	14.3	17.2	-4.1	3.2	4.0	-3.9	-3.6	-3.8
Length with tail	7.8	28.5	32.0	-5.7	5.0	5.6	-5.6	-5.2	-4.9
Length without tail	5.0	10.8	12.7	-3.5	3.4	3.3	-3.6	-3.0	-2.9
Times rat made contact with spout	0.9	1.1	1.5	1.0	-1.2	-1.1	1.0	1.1	-0.7
Lifetime Intake	1.0	1.1	2.3	1.3	-0.3	-1.1	1.0	0.8	1.5
Liver weight, left	0.5	0.8	1.7	0.9	-1.3	-0.9	0.7	0.9	-0.4
Liver weight, right	0.1	0.2	0.7	0.4	-0.8	-0.3	0.2	0.6	-0.3
Locomotor activity	0.5	0.7	2.2	0.7	-1.5	-0.7	0.7	0.5	-0.7
Locomotor testing distance	0.4	0.6	1.5	0.8	-1.2	-0.7	0.8	0.6	-0.5
Locomotor testing rearing	2.0	3.1	4.9	1.8	-1.9	-2.0	1.7	2.2	0.6
Locomotion in novel chamber	0.1	0.2	0.4	0.3	-0.7	-0.1	0.4	-0.4	0.3
Locomotion in novel chamber post-restriction	0.2	0.2	1.0	-0.3	-0.0	0.4	0.0	-1.0	0.2
Fecal boli incidents, locomotor time 1	1.7	1.8	2.7	1.5	-1.6	-1.1	1.6	1.0	1.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	-0.8	-0.2	0.3	-0.6	-0.3	-0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.0	0.2	0.0
Bouts of movement, locomotor time 1	0.7	0.8	1.6	-0.8	1.3	0.8	-0.5	-1.0	0.5
Total resting periods, locomotor time 1	0.6	0.7	1.4	-0.8	1.1	0.8	-0.4	-1.2	0.5
Rest time, locomotor task time 1	0.7	0.8	1.7	0.6	-1.2	-0.6	1.3	0.3	1.0
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.1	0.3	-0.1	-0.1	0.3	-0.3
Vertical activity count, locomotor time 1	1.8	1.9	2.9	-1.7	1.7	1.3	-1.6	-0.8	-0.9
Time >=10cm from walls, locomotor time 2	1.5	1.6	2.2	1.1	-1.3	-1.3	1.5	1.0	1.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	0.0	-0.1	0.2	0.1	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.3	0.2	0.1
Rest time, locomotor task time 2	0.3	0.4	0.7	0.3	-0.8	-0.4	0.8	0.5	0.6
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.3	0.0	-0.6	0.3	0.6	0.4
Vertical activity count, locomotor time 2	0.7	0.8	1.5	-1.0	1.2	0.8	-0.9	-0.8	-0.3
Light reinforcement 1	0.1	0.2	0.7	0.2	-0.0	-0.5	0.2	0.5	0.9
Light reinforcement 2	2.3	3.1	3.4	1.7	-1.8	-1.8	1.7	1.9	1.7
Bone: marrow area	1.8	3.8	4.8	-2.2	1.9	2.1	-2.0	-2.1	-1.4
Bone: maximum diameter	1.3	2.4	2.9	-1.6	1.5	1.6	-1.7	-1.5	-1.3
Bone: maximum force	2.4	4.2	4.8	-2.2	2.1	2.1	-2.2	-2.1	-1.5
Bone: maximum moment	2.9	5.0	5.6	-2.4	2.3	2.3	-2.4	-2.3	-1.7
Mean time between licks in bursts	0.1	0.1	0.3	-0.2	0.3	0.1	-0.3	-0.1	0.5
Mean num. licks in bursts	1.6	1.9	5.4	-1.2	0.5	1.2	-1.1	-1.3	-2.3
Cd content in liver	0.1	0.1	0.5	-0.0	0.0	0.1	-0.1	-0.0	-0.7
Co content in liver	0.3	0.3	0.5	0.3	-0.6	-0.5	0.4	0.7	0.5
Cu content in liver	0.4	0.5	0.9	-0.9	0.8	0.7	-0.7	-0.5	-0.5
Fe content in liver	0.0	0.0	0.1	0.1	-0.0	-0.1	0.1	0.1	0.3
K content in liver	0.1	0.1	0.1	-0.3	0.2	0.2	-0.4	-0.1	0.3
Mg content in liver	0.4	0.4	0.7	0.5	-0.8	-0.6	0.4	0.7	0.6
Mn content in liver	0.8	0.9	2.1	0.8	-1.4	-0.9	0.9	0.9	0.2
Na content in liver	1.4	1.5	2.5	-1.2	1.6	1.3	-1.3	-1.2	-0.4
Rb content in liver	0.2	0.3	1.4	0.1	0.2	-0.2	0.2	0.2	1.2
Se content in liver	7.1	8.7	10.6	3.1	-3.3	-3.2	3.0	3.0	2.0
Sr content in liver	0.7	0.6	1.2	0.8	-1.1	-0.8	0.8	0.8	0.3
Zn content in liver	0.1	0.1	0.2	0.0	-0.2	-0.3	0.1	0.4	0.5
Bone: minimum diameter	3.1	5.7	7.6	-2.6	2.8	2.5	-2.4	-2.6	-0.9
Time in familiar zone, hab. session 1	0.6	0.6	2.6	-0.5	-0.0	0.5	-0.4	-0.4	-1.6
Time in novel zone, hab. session 1	1.5	1.5	4.5	1.1	-0.5	-1.1	0.9	1.1	2.1
Total zone transitions, hab. session 1	0.1	0.1	0.4	-0.1	0.2	0.1	0.4	-0.1	0.6
Total locomotion distance, hab. session 1	1.1	1.6	2.4	-1.4	1.2	1.5	-1.1	-1.5	-0.4
Locomotion velocity, hab. session 1	0.7	1.1	1.7	-1.2	0.8	1.2	-0.8	-1.3	-0.6
Time in familiar zone, hab. session 2	2.5	2.5	3.3	-1.8	1.1	1.8	-1.6	-1.7	-1.5
Time in novel zone, hab. session 2	1.6	1.6	2.2	1.5	-1.0	-1.4	1.3	1.3	0.9
Total zone transitions, hab. session 2	2.9	3.8	4.5	1.8	-1.8	-2.0	2.1	2.0	2.0
Total locomotion distance, hab. session 2	0.2	0.3	1.3	0.1	-0.0	-0.2	0.4	0.2	1.1
Locomotion velocity, hab. session 2	0.2	0.3	1.0	0.2	-0.2	-0.3	0.6	0.3	1.0
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.2	0.5	0.2	-0.5	-0.2	0.2
Novelty place preference	0.1	0.1	0.2	-0.1	0.5	0.1	-0.3	-0.1	0.3
Time in novel zone, NPP test	0.1	0.1	0.3	0.1	0.3	-0.1	-0.1	0.1	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	0.1	-0.3	-0.3	0.5	0.2	0.1
Total locomotion distance, NPP test	2.3	3.2	3.9	-2.0	1.6	1.9	-1.7	-2.0	-1.6
Locomotion velocity, NPP test	2.5	3.6	4.4	-2.1	1.6	2.0	-1.8	-2.1	-1.7
Intraocular pressure	0.1	0.1	0.6	0.2	0.3	0.0	0.1	-0.1	0.8
Delta distance traveled before/after self-admin	4.6	5.0	6.2	-2.4	2.5	2.4	-2.5	-2.1	-1.3
Delta ambulatory time before/after self-admin	5.1	5.6	7.3	-2.5	2.7	2.5	-2.7	-2.1	-1.4
Parametrial fat weight	0.6	1.2	4.2	0.3	-1.6	-0.4	0.1	0.7	-2.1
Pavlov. Cond. lever latency	0.2	0.2	0.7	-0.2	0.3	0.5	-0.3	-0.4	-0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.6	-0.8	-0.8	0.7	0.7	0.4
Pavlov. Cond. change in total contacts	0.5	0.5	2.2	0.2	-0.1	-0.5	0.5	0.5	1.5
Pavlov. Cond. index score	0.4	0.6	0.7	0.5	-0.8	-0.8	0.7	0.8	0.8
Pavlov. Cond. latency score	0.2	0.3	0.7	0.3	-0.5	-0.5	0.5	0.5	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.4	0.2	0.2	-0.3	-0.3	0.5
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	-0.7	0.9	0.9	-0.8	-0.9	-0.6
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.2	1.0	-0.9	-0.9	1.1	0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.9	0.6	-0.9	-0.9	0.8	0.9	1.0
Pavlov. Cond. response bias	0.1	0.1	0.4	0.2	-0.6	-0.4	0.3	0.4	0.1
Pavlov. Cond. lever latency	4.7	6.4	7.2	2.7	-2.7	-2.7	2.6	2.7	1.7
Pavlov. Cond. magazine entry latency	2.9	3.4	4.2	-1.9	1.8	2.0	-2.0	-2.1	-1.0
Pavlov. Cond. change in total contacts	7.6	10.5	13.8	-3.3	3.7	3.4	-3.4	-3.4	-1.8
Pavlov. Cond. index score	4.8	6.2	7.1	-2.6	2.7	2.7	-2.6	-2.7	-1.6
Pavlov. Cond. latency score	4.6	5.8	6.6	-2.5	2.6	2.6	-2.5	-2.6	-1.5
Pavlov. Cond. lever contacts	4.0	5.5	6.9	-2.5	2.6	2.4	-2.4	-2.4	-1.5
Pavlov. Cond. magazine entry number	3.5	4.3	4.8	2.1	-2.2	-2.2	2.1	2.1	1.7
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.7	0.9	-1.0	-1.3	1.1	1.3	0.8
Pavlov. Cond. lever-magazine prob. diff.	4.7	6.0	6.8	-2.5	2.6	2.6	-2.6	-2.6	-1.8
Pavlov. Cond. response bias	4.5	6.2	8.2	-2.6	2.9	2.6	-2.6	-2.5	-1.5
Time in closed arm before self-admin	3.0	3.3	4.3	2.0	-1.3	-2.0	1.9	1.6	2.1
Time in closed arm after self-admin	0.2	0.2	0.5	0.1	0.3	0.2	0.1	-0.7	0.5
Time in open arm before self-admin	5.1	5.6	6.6	-2.5	1.8	2.4	-2.6	-2.4	-2.4
Time in open arm after self-admin	1.4	1.5	2.4	-1.5	0.9	1.1	-1.5	-0.4	-1.5
Bone: periosteal estimation	2.0	4.1	4.7	-2.2	1.9	2.1	-2.1	-2.1	-1.7
Bone: periosteal perimeter	1.4	2.3	3.2	-1.5	1.3	1.6	-1.5	-1.8	-1.4
Bone: post-yield work	1.7	2.4	4.3	-1.7	2.1	1.5	-1.6	-1.6	-0.1
Progressive ratio test 1 active lever presses	0.5	0.6	1.6	-0.6	1.3	0.6	-0.3	-0.8	0.7
Progressive ratio test 1 breakpoint	0.8	0.9	1.9	-0.9	1.4	0.9	-0.6	-1.1	0.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.9	-0.7	1.4	0.7	-0.6	-0.7	1.2
Progressive ratio test 2 active lever presses	0.2	0.2	0.7	0.4	0.6	-0.2	0.2	-0.3	0.9
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	0.5	0.5	-0.3	0.3	-0.3	0.8
Progressive ratio test 2 inactive lever presses	1.7	1.9	3.6	-0.5	1.9	0.9	-0.6	-1.7	1.9
Incentive Sensitization - Responses	0.2	0.2	0.6	0.8	0.0	-0.4	0.5	0.0	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	0.8	0.0	-0.5	0.5	0.1	0.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	0.3	0.4	-0.1	-0.7	-0.3
Progressive ratio	0.0	0.0	0.1	-0.4	0.1	0.1	-0.2	-0.3	0.2
Food seeking constrained by brief footshock	3.2	3.9	4.8	-2.1	2.0	2.2	-2.0	-2.2	-1.3
Seeking ratio, punishment vs. effort	0.5	0.6	1.0	-0.7	1.0	0.9	-0.8	-0.8	-0.3
Retroperitoneal fat weight	1.5	5.0	7.8	2.4	-2.8	-2.3	2.1	2.5	0.1
Reaction time number correct	0.1	0.1	0.4	-0.1	-0.2	-0.1	0.2	0.6	-0.3
Reaction time mean minus median	0.4	0.6	1.1	-0.6	0.7	0.6	-1.0	-0.5	-0.8
Reaction time mean minus median AUC	0.9	1.1	2.0	-1.0	1.0	0.8	-1.4	-0.5	-1.4
Reaction time num false alarms	1.0	1.4	2.1	1.4	-0.9	-1.3	0.9	1.4	0.9
Reaction time num false alarms AUC	1.1	1.6	2.4	1.6	-1.1	-1.3	1.1	1.4	1.0
Reaction time trials correct on left	0.1	0.1	0.4	-0.1	-0.2	-0.1	0.2	0.6	-0.3
Reaction time trials on left	0.1	0.1	0.5	-0.1	-0.2	-0.1	0.2	0.7	-0.3
Reaction time mean	0.1	0.2	0.4	-0.0	0.5	0.2	-0.6	0.1	-0.6
Reaction time mean AUC	0.1	0.1	0.4	0.0	0.3	0.1	-0.5	0.2	-0.6
Median of all reaction times	0.0	0.1	0.1	0.2	0.3	-0.0	-0.3	0.3	-0.3
Reaction time omissions	0.1	0.2	0.4	0.2	-0.3	-0.3	-0.3	0.6	-0.6
Reaction time false alarm rate	0.7	0.9	1.7	1.3	-0.7	-1.1	0.8	0.8	1.0
Reaction time premature initiation rate	0.2	0.3	0.8	-0.7	0.6	0.4	-0.2	-0.4	0.9
Reaction time premature initiations	0.2	0.2	0.5	-0.6	0.5	0.3	-0.1	0.0	0.7
Std. dev. reaction times	0.5	0.7	1.4	-0.6	1.1	0.7	-1.2	-0.4	-0.8
Reaction time trials completed	0.1	0.1	0.5	-0.1	-0.2	-0.1	0.2	0.7	-0.3
Reaction time trials AUC	0.1	0.2	0.6	0.0	-0.4	-0.2	0.3	0.8	-0.5
Run reversals in cocaine runway, females	0.4	0.4	1.0	-0.4	1.0	0.5	-0.8	-0.1	-0.3
Run reversals in cocaine runway, males	0.7	0.6	2.1	0.1	-1.1	-0.3	-0.1	0.6	-1.4
Latency to leave start box in cocaine runway	0.1	0.1	0.5	-0.3	0.7	0.4	-0.1	-0.0	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	-0.1	0.4	0.1	-0.0	0.5	0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.2	-0.1	0.2	0.1	0.1	-0.1	-0.4
Std. dev. time between licks in bursts	0.9	1.1	1.9	-0.9	1.2	0.9	-0.8	-0.9	1.4
Total sessions with >9 infusions	1.2	1.3	2.0	1.2	-1.1	-1.3	1.1	1.4	0.8
Short access day 1 total inactive lever presses	0.8	0.9	3.3	-0.4	1.3	0.6	-0.2	-0.5	1.8
Short access day 10 total inactive lever presses	1.7	1.9	3.3	-1.2	1.6	1.6	-1.3	-1.8	-0.0
Short access day 1 total infusions	0.1	0.2	0.3	0.4	-0.2	-0.5	0.4	0.3	0.5
Short access day 10 total infusions	0.5	0.6	0.9	0.9	-0.5	-0.9	0.8	0.8	0.7
Short access total infusions	1.0	1.2	1.6	1.3	-1.0	-1.3	1.2	1.0	0.7
Short access day 1 locomotion	0.3	0.4	1.0	0.3	-0.4	-0.8	0.3	1.0	0.6
Short access day 10 total locomotion	0.9	1.0	1.8	-1.1	1.3	0.9	-0.9	-1.1	0.6
Short access total locomotion	0.8	0.8	1.5	0.8	-0.7	-1.0	0.9	0.7	1.2
One hour access (0.3 mA shock)	0.9	1.1	3.0	-0.7	1.7	0.9	-0.9	-1.1	0.5
Compulsive drug intake	0.0	0.0	0.1	-0.2	0.1	0.2	-0.3	-0.0	-0.2
One hour access (shock baseline)	0.2	0.3	1.0	0.2	0.7	-0.0	0.0	-0.4	1.0
Social response proportion	2.5	2.7	4.2	-1.6	1.7	1.9	-1.7	-2.0	-0.5
Social responses	1.1	1.4	2.1	-1.3	1.0	1.5	-1.2	-1.4	0.1
Social time	2.8	3.6	5.4	-1.9	2.3	2.0	-2.0	-2.0	-0.7
Soleus weight	0.1	0.2	0.5	0.2	-0.7	-0.5	0.5	0.6	0.1
Bone: stiffness	1.2	1.9	2.3	-1.5	1.5	1.5	-1.4	-1.5	-0.8
Tibialis anterior weight	0.2	0.6	1.8	0.2	-1.0	-0.4	0.4	0.6	-1.3
Time to tail flick, vehicle, before self-admin	1.1	1.1	2.2	1.5	-0.9	-0.9	1.1	0.9	1.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	-0.1	-0.1	0.4	-0.0	-0.6	0.1
Time to tail flick, test, before self-admin	0.9	0.9	2.0	0.9	0.3	-1.0	0.5	1.1	1.4
Time to tail flick, test, after self-admin	0.0	0.0	0.2	-0.1	0.1	-0.2	0.0	0.4	0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.6	-1.3	0.8	1.0	-1.0	-0.9	-0.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	-0.3	-1.0	-0.1	0.2	0.2	-0.8
Tibia length	2.4	6.8	7.2	-2.6	2.7	2.6	-2.7	-2.5	-2.5
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3	-0.3	0.1
Ambulatory time after self-admin	7.4	8.2	10.1	-3.1	3.2	3.2	-2.9	-2.9	-1.4
Bone: tissue strength	3.2	3.1	5.0	-1.9	2.2	1.7	-2.0	-1.7	-0.6
Total heroin consumption	0.5	0.6	1.4	-0.7	0.9	0.7	-0.3	-1.2	0.3
Bone: trabecular number	1.3	2.1	2.5	-1.6	1.5	1.4	-1.5	-1.4	-1.3
Bone: trabecular spacing	0.3	0.3	0.5	-0.6	0.1	0.6	-0.6	-0.6	-0.7
Bone: trabecular thickness	0.1	0.2	0.4	0.4	-0.2	-0.5	0.3	0.6	-0.2
Bone: trabecular tissue density	2.6	3.7	6.9	2.1	-2.6	-1.9	2.0	1.8	-0.4
Water consumed over 24 hours	0.3	0.4	0.5	-0.7	0.7	0.6	-0.7	-0.6	-0.6
Number of responses in last shaping day	0.4	0.4	1.7	-0.1	0.4	-0.1	0.4	-0.6	1.3