Hub : Genes

Scube1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Scube1 0.21 0.1 0.0e+00 0.23 0.21 0.21 0.22 1.4e-24 3.6e-23 6.7e-23 1.2e-23
2 IL gene expression Scube1 0.46 0.14 6.2e-11 0.26 0.26 0.27 0.25 6.1e-07 7.7e-07 3.0e-07 9.5e-07
3 pVTA gene expression Scube1 0.22 0.13 1.4e-09 0.22 0.2 0.15 0.21 1.1e-09 7.7e-09 6.0e-07 1.6e-09
4 Adipose gene expression Scube1 0.23 0.17 4.4e-09 0.08 0.05 0.07 0.07 6.9e-09 2.7e-06 2.2e-08 1.0e-08
5 NAcc gene expression Scube1 0.16 0.1 1.3e-10 0.09 0.08 0.09 0.09 6.0e-11 1.2e-09 3.4e-10 1.5e-10
6 BLA gene expression Scube1 0.05 0.05 4.4e-03 0.02 0.03 0.03 0.02 2.1e-02 9.4e-03 1.6e-02 2.9e-02
7 Brain isoform ratio XM_039079291.1 0.03 0.03 3.7e-03 0.01 0.02 -0 0.01 3.1e-02 7.5e-03 7.3e-01 4.9e-02
8 LHb mRNA stability Scube1 0.16 0.13 8.3e-03 0.01 0 -0.01 -0.01 2.2e-01 2.9e-01 5.8e-01 7.3e-01
9 RMTg gene expression Scube1 0.16 0.13 1.3e-03 0.06 0.05 0.1 0.07 1.3e-02 1.7e-02 1.1e-03 5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.40.5-0.7-0.7-0.6-0.6-0.60.70.70.60.1
Area under the delay curve1.92.03.1-1.5-1.6-1.5-1.4-1.41.41.41.8-0.2
BMI with tail1.75.66.42.42.32.42.42.5-2.4-2.5-2.41.9
BMI without tail0.61.21.71.11.21.11.21.3-1.0-0.9-1.10.7
Body weight1.35.68.72.22.32.32.83.0-2.3-2.1-2.31.8
Weight adjusted by age0.10.10.20.50.50.40.30.3-0.3-0.3-0.40.0
Bone surface0.00.00.2-0.10.0-0.00.10.00.00.1-0.10.4
Bone volume0.00.00.0-0.2-0.0-0.10.0-0.10.10.10.00.2
Breakpoint value in progressive ratio session0.10.10.40.10.20.20.40.4-0.2-0.1-0.20.7
Number of licking bursts0.30.31.6-0.4-0.4-0.3-0.3-0.40.50.60.3-1.3
Context. condit. distance diff. score5.26.38.22.92.62.82.52.5-2.7-2.8-2.40.0
Locomotion velocity, session 10.80.81.31.01.10.90.80.8-1.0-1.1-0.80.7
Locomotion distance, session 10.20.20.5-0.2-0.2-0.3-0.7-0.70.30.10.60.3
Locomotion velocity, session 21.11.22.11.21.31.11.11.1-0.9-1.1-1.50.2
Locomotion distance, session 20.60.91.5-0.9-0.8-1.1-1.2-1.21.00.71.00.4
Locomotion velocity, session 30.80.91.31.21.11.10.90.9-0.8-1.0-1.00.5
Locomotion distance, session 30.60.70.9-0.6-0.9-0.7-0.9-0.90.90.80.8-0.7
Stereotopy head waving bouts, day 31.01.11.60.91.20.71.11.1-1.0-1.0-1.31.2
Stereotopy head waving duration, day 34.75.77.42.52.72.22.62.6-2.4-2.3-2.71.1
Locomotion velocity, session 70.10.10.30.50.30.20.20.2-0.1-0.3-0.30.6
Locomotion distance, session 70.70.81.1-0.8-1.0-0.9-1.0-1.11.00.80.90.8
Stereotopy head waving bouts, day 74.65.28.02.72.82.12.52.5-2.3-2.3-2.1-0.4
Stereotopy head waving duration, day 72.93.55.12.12.21.72.12.1-1.8-1.7-1.8-0.7
Locomotion velocity, session 86.67.910.13.13.22.92.92.9-3.0-3.1-2.60.9
Locomotion distance, session 81.11.62.51.61.61.41.11.1-1.4-1.5-1.1-0.4
Degree of sensitization distance1.01.02.40.80.90.90.90.8-1.0-1.0-0.91.5
Degree of sensitization stereotypy3.33.75.32.32.31.92.12.1-1.9-1.9-1.7-0.7
Conditioned locomotion0.10.10.50.10.10.00.10.2-0.00.20.1-0.7
Cocaine response after cond. corrected0.30.32.60.20.20.2-0.1-0.0-0.0-0.00.1-1.6
Cocaine response after cond. not corrected0.50.64.80.30.20.2-0.1-0.0-0.0-0.0-0.0-2.2
Cocaine response before conditioning0.10.10.4-0.3-0.2-0.3-0.3-0.40.30.30.3-0.6
Saline control response0.10.20.40.30.50.40.50.4-0.3-0.1-0.5-0.6
Bone: connectivity density0.10.10.2-0.5-0.4-0.3-0.2-0.20.40.50.20.3
Bone: cortical apparent density1.31.72.3-1.4-1.5-1.5-1.4-1.41.31.21.50.3
Bone: cortical area1.21.82.41.41.51.51.51.5-1.5-1.3-1.3-0.1
Bone: cortical porosity0.40.50.80.60.60.70.80.9-0.6-0.5-0.90.3
Bone: cortical porosity0.91.01.61.01.01.11.01.2-1.0-0.9-1.2-0.3
Bone: cortical thickness0.10.21.4-0.3-0.2-0.10.40.3-0.10.10.31.2
Bone: cortical thickness0.20.20.40.50.40.50.50.4-0.6-0.6-0.50.2
Bone: cortical tissue density1.21.62.1-1.4-1.5-1.4-1.3-1.31.21.11.40.4
Condit. Reinf. active minus inactive responses1.61.82.6-1.4-1.2-1.6-1.3-1.31.31.41.4-1.2
Condit. Reinf. active-inactive response ratio0.10.10.8-0.10.1-0.20.00.00.00.2-0.1-0.9
Condit. Reinf. active responses3.74.55.1-2.1-2.0-2.3-2.2-2.22.22.12.1-1.8
Condit. Reinf. inactive responses3.23.84.8-2.1-2.1-1.9-2.2-2.22.11.92.0-0.5
Incentive salience index mean2.53.03.8-1.9-1.7-1.9-1.7-1.71.81.81.8-1.2
Condit. Reinf. lever presses2.43.23.7-1.9-1.7-1.8-1.9-1.91.91.81.8-1.0
Condit. Reinf. active minus inactive responses0.00.00.10.00.3-0.00.20.3-0.2-0.20.00.3
Condit. Reinf. active-inactive response ratio0.00.00.10.20.40.10.20.3-0.2-0.20.1-0.1
Condit. Reinf. active responses0.50.71.20.81.10.80.90.9-1.0-1.0-0.90.2
Condit. Reinf. inactive responses0.81.01.40.91.01.00.90.9-1.1-1.1-1.20.7
Condit. Reinf. lever presses0.10.20.6-0.4-0.2-0.3-0.6-0.60.30.20.1-0.8
Condit. Reinf. lever reinforcers received0.10.10.20.20.50.20.30.3-0.4-0.4-0.2-0.0
Conditioned reinforcement - actives0.30.30.6-0.8-0.5-0.6-0.4-0.40.50.50.7-0.3
Conditioned reinforcement - inactives0.10.10.7-0.1-0.1-0.1-0.1-0.10.0-0.10.30.9
Conditioned locomotion0.50.60.90.70.90.90.90.8-0.8-0.9-0.4-0.0
Patch foraging indifference point 0 sec0.10.10.4-0.3-0.4-0.3-0.3-0.20.30.40.20.7
Patch foraging indifference point AUC0.10.20.3-0.5-0.6-0.4-0.4-0.30.30.30.20.4
Delay disc. indifference point, 0s delay0.20.20.50.50.40.50.60.7-0.4-0.4-0.50.4
Delay disc. indifference point, 16s delay3.73.74.7-1.9-2.0-2.1-2.0-2.02.02.02.2-1.0
Delay disc. indifference point, 2s delay0.30.40.7-0.7-0.7-0.6-0.5-0.50.60.60.80.4
Delay disc. indifference point, 24s delay0.60.60.9-0.9-0.9-0.9-0.7-0.70.70.71.00.1
Delay disc. indifference point, 4s delay0.10.10.5-0.0-0.3-0.3-0.5-0.40.10.00.50.7
Delay disc. indifference point, 8s delay3.03.14.2-1.9-2.0-1.8-1.8-1.81.81.82.0-0.8
Indifference point function ln k1.11.62.71.21.21.11.61.5-1.2-1.0-1.01.2
Indifference point function log k1.11.62.71.21.21.11.61.5-1.2-1.0-1.01.2
Patch foraging total patch changes 0 sec0.10.10.3-0.4-0.4-0.4-0.3-0.30.40.40.20.5
Patch foraging total patch changes 12 sec0.10.20.50.40.20.40.10.1-0.4-0.5-0.70.5
Patch foraging total patch changes 18 sec0.10.10.2-0.5-0.3-0.3-0.10.00.30.40.10.4
Patch foraging total patch changes 24 sec0.10.10.2-0.3-0.4-0.3-0.4-0.40.40.3-0.0-0.3
Patch foraging total patch changes 6 sec0.00.10.50.1-0.00.00.10.2-0.1-0.1-0.00.7
Patch foraging time to switch 0 sec0.50.71.9-0.7-0.5-0.8-0.9-0.90.80.70.6-1.4
Patch foraging water rate 0 sec0.81.22.01.21.01.41.01.1-1.1-1.2-1.30.3
Patch foraging water rate 12 sec0.50.81.21.11.01.11.01.0-0.8-0.7-0.8-0.1
Patch foraging water rate 18 sec0.10.10.40.20.1-0.1-0.2-0.30.0-0.00.6-0.4
Patch foraging water rate 24 sec1.52.03.31.31.51.41.81.8-1.4-1.2-1.30.7
Patch foraging water rate 6 sec0.10.10.2-0.4-0.4-0.4-0.3-0.40.40.40.30.2
Seeking ratio, delayed vs. immediate footshock1.82.02.6-1.6-1.5-1.3-1.5-1.51.61.61.5-0.2
Distance traveled before self-admin0.00.00.2-0.1-0.2-0.0-0.4-0.40.1-0.1-0.10.1
Distance traveled after self-admin0.30.40.70.50.40.50.50.4-0.5-0.6-0.80.9
Extensor digitorum longus weight0.00.10.20.30.00.50.20.3-0.1-0.2-0.1-0.0
Bone: elastic displacement1.31.41.91.31.41.31.31.3-1.2-1.2-1.3-0.0
Bone: elastic work4.25.47.02.62.62.52.42.3-2.4-2.5-2.5-0.1
Bone: endosteal estimation2.55.48.22.92.72.71.91.9-2.3-2.5-2.5-1.0
Bone: endosteal perimeter2.04.25.82.42.42.21.81.8-1.9-1.9-2.1-1.8
Epididymis fat weight0.81.83.41.21.41.21.71.8-1.3-1.1-1.40.4
Delta time in closed arm before/after self-admin0.10.10.50.00.00.1-0.0-0.1-0.2-0.3-0.70.2
Delta time in open arm before/after self-admin0.50.41.60.80.60.80.10.1-0.4-0.5-0.5-1.3
Diff in mean of infusions in LGA sessions0.80.81.7-1.0-1.0-1.0-1.3-1.20.80.60.70.2
Delay discount exponential model param1.81.93.01.41.51.51.41.4-1.3-1.3-1.7-0.1
Extinction: sum of active levers before priming0.20.20.6-0.2-0.4-0.1-0.7-0.80.20.10.2-0.3
Active lever presses in extinction session 60.60.61.00.80.80.70.70.7-0.8-0.8-0.71.0
Bone: final force0.91.42.11.31.31.31.01.0-1.4-1.4-1.30.3
Bone: final moment1.52.43.31.61.71.61.41.3-1.8-1.8-1.60.5
Food consumed during 24 hour testing period2.53.14.11.91.81.71.71.6-1.9-2.0-1.61.4
Glucose0.61.01.3-1.2-1.1-1.1-0.7-0.60.91.01.01.1
Heart weight1.72.43.21.51.61.61.81.8-1.8-1.5-1.7-0.3
Delay discount hyperbolic model param1.31.32.21.21.31.21.21.2-1.1-1.1-1.5-0.1
Intermittent access intake day 1-15 change0.90.91.6-1.0-0.8-1.0-0.9-0.90.90.90.7-1.3
Intermittent access intake escalation0.70.71.5-0.9-0.7-0.9-0.8-0.70.80.90.5-1.2
Intermittent access intake escalation 20.20.20.6-0.4-0.3-0.5-0.4-0.40.40.40.2-0.8
Intermitt. access day 1 inactive lever presses1.21.31.81.21.01.20.91.0-1.2-1.3-0.91.3
Intermitt. access day 15 inactive lever presses0.91.01.71.01.01.00.60.6-1.1-1.3-0.81.2
Intermitt. access escalation Index0.20.10.5-0.2-0.2-0.4-0.3-0.40.30.30.4-0.7
Intermittent access day 1 total infusions0.70.81.60.80.80.80.90.9-0.9-0.9-0.41.3
Intermittent access day 15 total infusions0.00.10.10.10.30.30.10.2-0.2-0.3-0.20.3
Intermittent access terminal intake (last 3 days)0.00.00.10.10.20.2-0.00.0-0.1-0.3-0.1-0.1
Intermittent access total infusions0.20.20.40.60.60.60.30.3-0.5-0.6-0.40.1
Intermittent access day 1 locomotion0.00.00.10.10.10.20.30.3-0.1-0.10.3-0.1
Intermittent access day 15 total locomotion0.20.21.10.40.50.50.20.2-0.3-0.4-0.3-1.1
Intermittent access total locomotion0.20.30.50.60.60.70.40.4-0.5-0.6-0.5-0.1
Intermittent access standard deviation0.40.40.70.80.80.70.60.6-0.7-0.8-0.6-0.2
Left kidney weight12.033.841.56.16.45.96.26.1-6.1-6.1-6.11.7
Right kidney weight14.139.547.56.76.96.46.66.5-6.7-6.7-6.52.2
Cocaine induced anxiety3.03.45.32.11.82.11.61.4-1.9-2.1-2.30.9
Post-drug Anxiety2.32.52.91.61.51.61.61.5-1.6-1.6-1.71.6
Baseline Anxiety2.42.64.1-1.9-1.7-2.0-1.0-0.81.71.92.00.7
Tail length0.10.20.4-0.6-0.3-0.40.00.10.40.60.50.4
Length with tail0.20.61.60.20.50.41.21.3-0.5-0.2-0.51.2
Length without tail0.51.24.70.60.70.61.11.1-0.8-0.8-0.82.2
Times rat made contact with spout2.12.42.71.41.41.51.61.5-1.6-1.6-1.61.6
Lifetime Intake0.50.60.90.80.90.90.60.6-0.8-0.9-0.80.0
Liver weight, left0.20.31.60.30.60.30.40.4-0.5-0.5-0.41.3
Liver weight, right0.10.20.40.30.50.30.60.6-0.3-0.2-0.4-0.2
Locomotor activity2.03.24.52.02.11.92.02.0-1.8-1.8-1.5-0.3
Locomotor testing distance0.10.21.10.30.20.1-0.2-0.20.0-0.10.3-1.0
Locomotor testing rearing0.60.93.70.90.90.90.50.6-0.7-0.7-0.5-1.9
Locomotion in novel chamber0.60.83.5-0.6-0.6-0.6-0.2-0.20.91.00.6-1.9
Locomotion in novel chamber post-restriction0.80.91.3-1.0-1.0-0.8-1.1-1.11.01.00.8-0.8
Fecal boli incidents, locomotor time 10.20.20.6-0.4-0.5-0.1-0.7-0.80.30.20.30.3
Change in fecal boli incidents, locomotor task0.50.51.20.60.70.50.91.1-0.6-0.4-0.6-0.5
Time >=10cm from walls, locomotor time 10.00.00.10.30.10.2-0.1-0.1-0.0-0.2-0.10.2
Bouts of movement, locomotor time 10.10.20.3-0.5-0.3-0.4-0.6-0.50.30.20.2-0.4
Total resting periods, locomotor time 10.30.30.6-0.8-0.6-0.6-0.8-0.70.50.40.3-0.1
Rest time, locomotor task time 10.00.00.1-0.2-0.0-0.1-0.4-0.20.10.0-0.20.3
Distance moved, locomotor task time 10.10.10.30.50.40.20.60.4-0.3-0.20.1-0.3
Vertical activity count, locomotor time 10.00.00.10.20.20.10.30.2-0.2-0.10.10.3
Time >=10cm from walls, locomotor time 20.30.30.5-0.6-0.7-0.7-0.6-0.50.70.70.4-0.1
Bouts of movement, locomotor time 20.20.30.4-0.6-0.5-0.7-0.5-0.50.40.50.5-0.0
Total resting periods, locomotor time 20.20.30.5-0.6-0.5-0.7-0.4-0.50.40.50.5-0.1
Rest time, locomotor task time 20.20.20.5-0.7-0.5-0.6-0.4-0.30.50.60.50.1
Distance moved, locomotor task time 20.70.81.21.11.00.90.90.9-0.8-0.9-0.80.1
Vertical activity count, locomotor time 20.70.70.91.00.90.90.90.9-0.8-0.8-1.00.4
Light reinforcement 10.30.50.80.80.90.80.50.5-0.6-0.6-0.7-0.7
Light reinforcement 20.40.50.90.70.90.60.80.8-0.5-0.5-0.80.6
Bone: marrow area2.75.98.83.02.82.82.02.1-2.4-2.6-2.6-0.9
Bone: maximum diameter5.09.211.63.43.43.33.23.2-3.2-3.1-3.0-0.0
Bone: maximum force2.64.45.52.32.32.32.12.0-2.3-2.3-2.20.5
Bone: maximum moment3.45.97.22.62.62.62.42.3-2.7-2.7-2.50.7
Mean time between licks in bursts1.41.97.8-1.1-1.0-1.0-1.3-1.31.11.20.5-2.8
Mean num. licks in bursts2.53.05.31.61.61.51.51.6-1.8-1.9-1.62.3
Cd content in liver1.82.02.51.31.41.41.41.4-1.5-1.2-1.6-1.5
Co content in liver0.70.81.10.81.00.80.90.9-0.8-0.8-1.1-0.6
Cu content in liver6.47.79.3-2.9-2.8-2.9-2.8-2.83.03.02.7-2.1
Fe content in liver0.30.30.50.60.60.60.70.7-0.6-0.5-0.50.1
K content in liver0.50.51.7-0.7-0.4-0.8-0.6-0.60.60.40.51.3
Mg content in liver1.11.23.2-1.1-0.8-1.2-0.8-0.80.90.81.01.8
Mn content in liver0.00.00.10.20.30.10.10.1-0.1-0.2-0.40.3
Na content in liver1.81.92.7-1.4-1.5-1.4-1.2-1.21.41.41.70.9
Rb content in liver0.00.00.2-0.20.1-0.20.10.10.00.1-0.3-0.5
Se content in liver1.21.41.9-1.3-1.2-1.4-1.3-1.31.31.21.2-0.0
Sr content in liver0.70.70.9-0.9-1.0-0.9-0.9-0.90.80.90.6-0.6
Zn content in liver0.91.01.3-1.1-1.0-1.1-1.0-1.01.11.11.0-1.0
Bone: minimum diameter0.61.12.51.11.21.20.80.8-0.9-0.8-0.9-1.6
Time in familiar zone, hab. session 10.30.30.40.60.50.60.30.3-0.5-0.6-0.50.6
Time in novel zone, hab. session 11.01.02.30.80.90.91.01.0-0.8-0.6-1.1-1.5
Total zone transitions, hab. session 11.72.42.8-1.7-1.6-1.7-1.6-1.61.61.61.70.3
Total locomotion distance, hab. session 10.40.61.0-0.7-0.6-1.0-0.8-0.80.80.80.80.3
Locomotion velocity, hab. session 10.60.91.3-0.9-0.8-1.2-0.9-0.91.00.91.10.8
Time in familiar zone, hab. session 20.20.20.4-0.5-0.4-0.4-0.4-0.40.50.50.4-0.6
Time in novel zone, hab. session 20.90.91.21.00.90.91.11.1-1.0-0.9-0.90.4
Total zone transitions, hab. session 20.20.21.6-0.00.0-0.1-0.2-0.20.0-0.20.21.3
Total locomotion distance, hab. session 20.10.20.3-0.2-0.2-0.5-0.4-0.40.30.20.50.6
Locomotion velocity, hab. session 20.40.50.9-0.6-0.5-0.8-0.7-0.70.60.50.80.9
Novel to familiar place preference ratio2.42.43.21.61.71.41.81.8-1.6-1.4-1.5-1.1
Novelty place preference3.23.24.21.81.91.72.02.0-1.9-1.6-1.8-1.1
Time in novel zone, NPP test4.44.55.72.22.32.12.42.4-2.2-2.0-2.1-1.2
Total zone transitions, NPP test0.40.51.1-0.6-0.6-0.8-1.0-1.00.60.50.7-0.0
Total locomotion distance, NPP test0.20.20.4-0.3-0.3-0.5-0.6-0.60.50.30.4-0.2
Locomotion velocity, NPP test0.91.31.9-1.0-1.1-1.3-1.4-1.41.21.01.2-0.4
Intraocular pressure0.40.50.80.80.70.90.70.8-0.8-0.7-0.80.0
Delta distance traveled before/after self-admin1.81.92.81.41.51.31.71.6-1.3-1.3-1.50.9
Delta ambulatory time before/after self-admin2.62.94.51.61.71.62.12.0-1.6-1.5-2.00.8
Parametrial fat weight0.20.41.7-0.8-0.6-0.6-0.3-0.10.50.50.41.3
Pavlov. Cond. lever latency3.03.74.82.11.92.22.02.0-2.0-2.0-2.00.9
Pavlov. Cond. magazine entry latency2.32.93.8-1.9-1.9-1.9-1.6-1.61.81.81.9-0.2
Pavlov. Cond. change in total contacts2.72.83.7-1.9-1.8-1.9-1.6-1.61.71.81.9-0.3
Pavlov. Cond. index score1.92.43.1-1.7-1.7-1.8-1.4-1.41.61.61.7-0.4
Pavlov. Cond. latency score1.62.02.7-1.6-1.5-1.6-1.3-1.31.51.51.6-0.7
Pavlov. Cond. lever contacts3.44.05.2-2.2-2.0-2.3-2.0-2.02.12.12.1-0.7
Pavlov. Cond. magazine entry number2.22.73.61.91.81.91.51.5-1.7-1.8-1.90.3
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.6-0.7-0.7-0.7-0.80.60.60.8-0.5
Pavlov. Cond. lever-magazine prob. diff.2.43.03.9-2.0-1.9-2.0-1.6-1.61.81.91.9-0.3
Pavlov. Cond. response bias3.64.35.6-2.4-2.3-2.4-1.9-1.92.22.32.2-0.4
Pavlov. Cond. lever latency0.20.30.50.70.50.50.60.6-0.5-0.4-0.6-0.2
Pavlov. Cond. magazine entry latency2.73.14.1-2.0-2.0-1.9-2.0-2.01.91.61.50.5
Pavlov. Cond. change in total contacts0.20.20.4-0.6-0.3-0.5-0.6-0.60.30.20.30.6
Pavlov. Cond. index score1.31.72.4-1.6-1.4-1.4-1.5-1.51.31.21.10.3
Pavlov. Cond. latency score1.61.92.6-1.6-1.5-1.5-1.6-1.61.41.21.20.5
Pavlov. Cond. lever contacts0.20.30.5-0.7-0.5-0.5-0.6-0.60.50.40.40.6
Pavlov. Cond. magazine entry number1.72.12.81.61.61.51.71.7-1.5-1.2-1.2-0.6
Pavlov. Cond. intertrial magazine entries2.33.03.71.81.81.91.91.9-1.9-1.8-1.80.2
Pavlov. Cond. lever-magazine prob. diff.1.51.92.8-1.7-1.4-1.5-1.6-1.61.51.31.20.2
Pavlov. Cond. response bias0.50.71.2-1.1-0.8-0.8-0.9-0.90.80.70.70.5
Time in closed arm before self-admin2.62.94.0-1.8-1.7-1.7-1.8-1.71.71.72.0-1.0
Time in closed arm after self-admin0.20.20.6-0.5-0.4-0.5-0.1-0.20.40.50.3-0.8
Time in open arm before self-admin0.10.10.2-0.2-0.3-0.1-0.3-0.20.20.2-0.10.5
Time in open arm after self-admin0.20.20.40.60.30.7-0.3-0.1-0.1-0.3-0.4-0.6
Bone: periosteal estimation2.65.37.22.72.72.62.22.1-2.4-2.4-2.4-0.8
Bone: periosteal perimeter2.94.96.22.42.52.42.22.2-2.2-2.0-2.3-1.6
Bone: post-yield work0.91.21.61.11.01.20.90.9-1.3-1.3-1.11.1
Progressive ratio test 1 active lever presses0.00.00.1-0.2-0.1-0.10.20.20.00.10.30.1
Progressive ratio test 1 breakpoint0.10.10.4-0.5-0.4-0.4-0.1-0.10.30.40.6-0.0
Progressive ratio test 1 inactive lever presses0.00.00.10.20.10.3-0.00.1-0.2-0.3-0.30.1
Progressive ratio test 2 active lever presses0.50.52.70.40.50.50.20.3-0.6-0.8-0.21.6
Progressive ratio test 2 breakpoint0.50.52.70.40.50.50.30.4-0.6-0.8-0.21.6
Progressive ratio test 2 inactive lever presses0.30.42.90.20.20.2-0.1-0.1-0.3-0.50.11.7
Incentive Sensitization - Responses1.51.64.91.11.01.10.50.7-1.1-1.4-1.32.2
Incentive Sensitization - Breakpoint1.71.84.91.21.21.20.60.8-1.2-1.6-1.42.2
Sum of active levers in priming session hrs 5-60.10.10.40.30.10.3-0.4-0.3-0.1-0.3-0.1-0.6
Progressive ratio0.10.10.3-0.4-0.3-0.2-0.2-0.20.20.20.20.5
Food seeking constrained by brief footshock0.50.60.90.61.00.81.00.9-0.8-0.7-0.60.0
Seeking ratio, punishment vs. effort0.20.30.50.60.70.50.60.5-0.6-0.6-0.4-0.3
Retroperitoneal fat weight0.62.03.51.21.51.11.81.9-1.3-1.2-1.51.0
Reaction time number correct1.31.92.4-1.2-1.2-1.5-1.4-1.51.41.51.5-0.8
Reaction time mean minus median0.30.30.80.50.50.50.80.9-0.7-0.6-0.2-0.1
Reaction time mean minus median AUC0.81.01.31.00.91.11.11.2-1.1-1.0-0.9-0.7
Reaction time num false alarms0.20.21.60.30.30.3-0.0-0.0-0.10.1-0.0-1.3
Reaction time num false alarms AUC0.10.21.10.30.30.4-0.0-0.1-0.2-0.10.0-1.1
Reaction time trials correct on left1.31.92.4-1.2-1.2-1.5-1.4-1.51.41.51.5-0.8
Reaction time trials on left1.42.02.5-1.2-1.2-1.5-1.5-1.61.51.51.6-0.9
Reaction time mean0.00.00.2-0.4-0.2-0.30.1-0.00.10.20.2-0.0
Reaction time mean AUC0.00.10.2-0.4-0.2-0.30.0-0.10.10.30.2-0.1
Median of all reaction times0.10.20.5-0.7-0.4-0.5-0.2-0.30.40.50.30.2
Reaction time omissions0.40.52.3-0.5-0.5-0.5-0.5-0.50.40.50.7-1.5
Reaction time false alarm rate0.40.50.90.80.80.90.60.6-0.7-0.7-0.7-0.6
Reaction time premature initiation rate0.30.43.20.10.2-0.00.00.0-0.2-0.40.31.8
Reaction time premature initiations0.30.51.8-0.4-0.4-0.6-0.5-0.60.50.30.91.3
Std. dev. reaction times0.20.20.70.20.40.20.70.6-0.5-0.3-0.2-0.8
Reaction time trials completed1.42.02.5-1.2-1.2-1.5-1.5-1.61.51.51.6-0.9
Reaction time trials AUC1.01.51.9-1.0-1.0-1.3-1.3-1.41.31.31.4-0.8
Run reversals in cocaine runway, females2.32.23.8-1.9-1.7-1.6-1.0-1.01.82.01.4-0.1
Run reversals in cocaine runway, males1.21.21.81.11.11.31.21.2-1.1-1.0-1.30.1
Latency to leave start box in cocaine runway0.60.71.00.90.70.90.60.6-0.8-1.0-0.61.0
Latency to leave start box in cocaine runway, F0.20.21.30.30.00.3-0.3-0.3-0.2-0.40.11.1
Latency to leave start box in cocaine runway, M1.31.21.51.21.21.11.11.1-1.2-1.2-0.90.4
Std. dev. time between licks in bursts0.80.91.2-1.1-0.8-1.0-1.1-1.11.01.00.6-0.7
Total sessions with >9 infusions0.30.40.90.30.50.60.70.7-0.5-0.3-0.6-0.9
Short access day 1 total inactive lever presses2.73.04.01.91.92.01.51.5-1.9-2.0-1.90.6
Short access day 10 total inactive lever presses3.23.64.62.22.02.01.81.7-2.0-2.1-1.71.3
Short access day 1 total infusions1.21.31.91.11.21.31.11.1-1.2-1.3-1.4-0.1
Short access day 10 total infusions0.10.10.3-0.3-0.2-0.2-0.1-0.20.20.30.6-0.5
Short access total infusions0.80.91.21.01.11.11.00.9-1.0-1.0-1.0-0.3
Short access day 1 locomotion0.10.10.30.1-0.10.3-0.5-0.40.0-0.1-0.1-0.5
Short access day 10 total locomotion1.41.55.2-0.8-1.0-0.8-1.3-1.31.00.91.1-2.3
Short access total locomotion0.40.53.6-0.1-0.10.0-0.4-0.40.10.20.4-1.9
One hour access (0.3 mA shock)0.10.10.5-0.1-0.2-0.1-0.7-0.60.30.10.3-0.4
Compulsive drug intake0.20.20.7-0.0-0.4-0.2-0.9-0.80.2-0.00.50.3
One hour access (shock baseline)0.10.20.5-0.3-0.2-0.2-0.4-0.40.40.40.2-0.7
Social response proportion0.30.31.10.10.20.30.50.5-0.4-0.3-0.71.0
Social responses0.30.40.6-0.7-0.5-0.6-0.5-0.50.60.60.7-0.7
Social time2.63.55.0-2.2-2.1-1.9-1.9-2.01.81.91.8-0.3
Soleus weight0.31.04.70.80.50.80.60.5-0.8-0.9-0.72.2
Bone: stiffness0.91.52.11.31.31.41.11.1-1.4-1.3-1.3-0.1
Tibialis anterior weight0.20.81.3-0.9-1.2-0.9-1.0-1.00.90.81.00.0
Time to tail flick, vehicle, before self-admin0.10.10.20.10.20.20.40.4-0.2-0.20.3-0.2
Time to tail flick, vehicle, after self-admin0.60.73.1-0.4-0.5-0.3-0.8-0.80.60.50.6-1.8
Time to tail flick, test, before self-admin0.10.10.20.20.20.20.10.3-0.1-0.1-0.2-0.5
Time to tail flick, test, after self-admin2.22.23.9-1.4-1.6-1.3-2.0-1.91.51.31.3-0.8
Delta time to tail flick, vehicle, before/after SA0.10.10.30.50.30.5-0.4-0.2-0.3-0.5-0.5-0.1
Delta time to tail flick, test, before/after SA2.22.03.7-1.3-1.5-1.3-1.9-1.91.41.21.2-0.4
Tibia length0.72.12.81.51.61.41.71.7-1.5-1.4-1.50.2
Ambulatory time before self-admin0.10.10.20.1-0.10.3-0.3-0.2-0.2-0.3-0.10.5
Ambulatory time after self-admin0.40.51.40.50.40.50.50.4-0.5-0.6-1.01.2
Bone: tissue strength0.40.40.60.80.80.70.40.5-0.7-0.8-0.7-0.1
Total heroin consumption0.50.60.90.80.80.90.50.7-0.8-0.9-0.70.8
Bone: trabecular number0.10.10.3-0.4-0.3-0.2-0.3-0.30.40.50.1-0.6
Bone: trabecular spacing0.60.71.00.80.90.80.80.9-1.0-1.0-0.70.6
Bone: trabecular thickness0.40.50.9-0.9-0.6-0.8-0.5-0.60.80.80.60.1
Bone: trabecular tissue density0.50.81.1-0.9-1.0-1.1-1.0-1.00.80.70.9-0.1
Water consumed over 24 hours4.95.96.62.62.42.42.52.5-2.5-2.5-2.41.9
Number of responses in last shaping day0.91.01.5-1.1-0.9-1.1-1.0-0.90.90.91.20.9