Hub : Genes

Scube1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Scube1	0.21	0.1	0.0e+00	0.23	0.21	0.21	0.22	1.9e-24	1.0e-22	1.3e-22	1.0e-23
2	IL	gene expression	Scube1	0.5	0.14	3.6e-13	0.34	0.32	0.32	0.34	4.2e-09	2.0e-08	1.4e-08	6.2e-09
3	pVTA	gene expression	Scube1	0.13	0.07	4.2e-14	0.18	0.16	0.17	0.18	1.9e-14	5.7e-13	1.1e-13	2.1e-14
4	Adipose	gene expression	Scube1	0.02	0.01	6.0e-03	0.01	0.01	0.01	0.01	1.7e-02	1.9e-02	1.8e-02	2.5e-02
5	LHb	mRNA stability	Scube1	0.15	0.1	2.8e-03	0.14	0.01	0.04	0.08	3.9e-04	1.6e-01	3.3e-02	7.1e-03
6	NAcc	gene expression	Scube1	0.06	0.04	4.9e-08	0.04	0.04	0.04	0.04	2.5e-07	2.9e-07	6.9e-07	2.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.3	0.6	1.0	0.7	0.9	0.6	1.0	-0.6	0.7
Area under the delay curve	1.6	1.9	2.4	1.3	1.3	1.4	1.5	-1.3	1.3
BMI with tail	1.7	5.7	6.6	-2.6	-1.9	-2.5	-2.5	2.4	-2.4
BMI without tail	0.5	1.6	2.3	-1.2	-1.2	-1.1	-1.0	1.5	-1.4
Body weight	1.4	6.3	7.8	-2.3	-2.7	-2.3	-2.4	2.5	-2.8
Weight adjusted by age	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.4	0.4	-0.5
Bone surface	0.1	0.1	0.6	0.3	0.1	0.2	0.7	-0.4	0.1
Bone volume	0.1	0.2	0.6	0.3	0.2	0.2	0.8	-0.3	0.2
Breakpoint value in progressive ratio session	0.1	0.1	0.6	0.1	-0.8	0.0	0.1	0.1	-0.5
Number of licking bursts	0.1	0.1	0.2	0.4	0.0	0.3	0.4	-0.5	0.3
Context. condit. distance diff. score	5.6	6.8	8.6	-2.9	-2.5	-2.8	-2.2	2.6	-2.6
Locomotion velocity, session 1	0.8	0.9	1.7	-0.9	-1.3	-0.9	-1.1	0.4	-0.8
Locomotion distance, session 1	0.2	0.3	0.6	0.2	0.5	0.4	-0.0	-0.8	0.8
Locomotion velocity, session 2	1.2	1.4	2.9	-1.1	-1.0	-1.1	-1.7	1.1	-1.0
Locomotion distance, session 2	0.8	1.1	1.8	0.9	1.2	1.1	0.1	-1.2	1.3
Locomotion velocity, session 3	0.7	0.8	1.3	-1.1	-0.5	-1.1	-1.0	0.7	-0.8
Locomotion distance, session 3	0.9	1.0	2.3	0.7	1.5	0.7	0.9	-1.1	0.9
Stereotopy head waving bouts, day 3	0.8	1.0	1.5	-0.9	-1.1	-0.7	-1.1	1.2	-0.9
Stereotopy head waving duration, day 3	5.3	6.3	8.1	-2.4	-2.7	-2.2	-2.5	2.8	-2.4
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	-0.0	-0.1	-0.5	0.4	-0.3
Locomotion distance, session 7	0.7	0.9	1.8	0.8	1.3	0.9	0.9	-1.0	0.7
Stereotopy head waving bouts, day 7	4.1	4.6	6.3	-2.2	-2.2	-1.9	-2.5	2.0	-2.0
Stereotopy head waving duration, day 7	3.3	4.0	4.7	-2.0	-2.1	-1.7	-2.1	2.2	-1.9
Locomotion velocity, session 8	7.2	8.6	10.4	-3.1	-3.1	-2.9	-3.2	2.5	-2.7
Locomotion distance, session 8	1.5	2.1	2.8	-1.7	-1.5	-1.4	-1.6	1.3	-1.3
Degree of sensitization distance	1.0	1.0	1.4	-0.8	-1.2	-0.9	-1.0	1.1	-1.0
Degree of sensitization stereotypy	3.9	4.3	5.9	-2.1	-2.0	-1.9	-2.4	2.0	-1.9
Conditioned locomotion	0.1	0.1	0.2	-0.1	-0.5	-0.1	-0.3	0.2	-0.2
Cocaine response after cond. corrected	0.0	0.0	0.2	-0.4	-0.1	-0.2	0.1	-0.1	0.0
Cocaine response after cond. not corrected	0.0	0.0	0.2	-0.4	-0.1	-0.3	0.0	0.0	0.1
Cocaine response before conditioning	0.1	0.1	0.2	0.3	0.2	0.3	0.1	-0.4	0.4
Saline control response	0.2	0.3	0.8	-0.4	-0.9	-0.5	-0.5	-0.1	-0.5
Bone: connectivity density	0.1	0.1	0.3	0.4	0.4	0.3	0.6	-0.0	0.1
Bone: cortical apparent density	2.1	2.8	3.8	1.7	2.0	1.7	1.2	-1.8	1.6
Bone: cortical area	1.2	1.8	2.5	-1.3	-1.6	-1.4	-1.0	1.3	-1.5
Bone: cortical porosity	0.2	0.2	0.3	-0.4	-0.4	-0.6	-0.3	0.6	-0.6
Bone: cortical porosity	1.2	1.3	1.5	-1.0	-1.2	-1.2	-1.1	1.2	-1.2
Bone: cortical thickness	0.0	0.1	0.1	0.4	-0.4	0.2	0.3	-0.1	-0.3
Bone: cortical thickness	0.3	0.4	1.0	-0.5	-1.0	-0.5	-0.4	0.5	-0.7
Bone: cortical tissue density	1.8	2.5	3.5	1.6	1.9	1.6	1.1	-1.8	1.5
Condit. Reinf. active minus inactive responses	1.9	2.1	2.8	1.4	1.7	1.6	1.2	-1.5	1.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	0.2	0.1	0.0	0.2	-0.0
Condit. Reinf. active responses	4.0	4.9	6.0	2.1	2.5	2.2	1.8	-2.3	2.3
Condit. Reinf. inactive responses	3.5	4.3	5.5	2.1	2.1	1.9	1.6	-2.4	2.2
Incentive salience index mean	2.9	3.6	4.1	1.9	2.0	1.9	1.8	-2.0	1.8
Condit. Reinf. lever presses	2.7	3.8	4.8	2.0	1.9	1.9	1.8	-2.2	1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.6	0.1	-0.2	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.1	-0.7	-0.0	-0.2	0.0	-0.1
Condit. Reinf. active responses	0.6	0.9	2.0	-0.6	-1.4	-0.7	-1.0	0.7	-0.8
Condit. Reinf. inactive responses	0.8	1.0	1.4	-0.9	-1.2	-1.0	-0.9	1.1	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.4	0.5	0.2	0.4	0.3	-0.3	0.7
Condit. Reinf. lever reinforcers received	0.1	0.2	0.8	-0.0	-0.9	-0.2	-0.4	0.2	-0.3
Conditioned reinforcement - actives	0.0	0.1	0.3	0.2	0.5	0.2	0.1	-0.2	0.2
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.3	-0.1	-0.3	-0.7	0.7	-0.5
Conditioned locomotion	0.3	0.4	0.7	-0.5	-0.4	-0.7	-0.8	0.8	-0.6
Patch foraging indifference point 0 sec	0.1	0.1	0.1	0.4	0.4	0.4	0.2	0.2	0.3
Patch foraging indifference point AUC	0.4	0.6	1.0	0.7	0.9	0.6	0.7	-1.0	0.7
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	-0.6	-0.5	-0.6	-0.6	0.6	-0.8
Delay disc. indifference point, 16s delay	3.1	3.4	4.4	1.8	1.7	1.8	2.1	-1.8	1.9
Delay disc. indifference point, 2s delay	0.4	0.4	0.6	0.7	0.7	0.7	0.6	-0.5	0.6
Delay disc. indifference point, 24s delay	0.7	0.8	1.2	0.9	0.8	0.8	1.1	-0.8	0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.0	0.4	0.3	0.2	-0.1	0.3
Delay disc. indifference point, 8s delay	2.7	3.2	3.5	1.8	1.8	1.8	1.8	-1.9	1.7
Indifference point function ln k	1.0	1.7	2.3	-1.1	-1.5	-1.0	-1.1	1.4	-1.5
Indifference point function log k	1.0	1.7	2.3	-1.1	-1.5	-1.0	-1.1	1.4	-1.5
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.5	0.5	0.5	0.3	0.1	0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.3	-0.0	-0.3	-0.3	0.2	-0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.5	-0.0	0.4	0.6	-0.2	0.0
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	0.4	0.7	0.4	0.3	-0.0	0.4
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.0	-0.0	0.0	0.4	0.1	0.0
Patch foraging time to switch 0 sec	0.3	0.5	0.9	0.5	0.5	0.8	0.8	-0.7	1.0
Patch foraging water rate 0 sec	0.8	1.7	3.6	-1.0	-0.8	-1.4	-1.2	1.9	-1.2
Patch foraging water rate 12 sec	0.6	1.3	2.2	-0.9	-0.7	-1.1	-1.5	1.4	-0.9
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.0	0.2	0.0	-0.5	0.0	0.2
Patch foraging water rate 24 sec	1.8	2.5	3.7	-1.1	-1.9	-1.5	-1.5	1.6	-1.6
Patch foraging water rate 6 sec	0.1	0.2	0.3	0.4	0.6	0.5	0.3	-0.4	0.2
Seeking ratio, delayed vs. immediate footshock	1.7	2.1	3.1	1.8	1.6	1.3	1.5	-0.9	1.4
Distance traveled before self-admin	0.3	0.3	0.5	0.7	0.5	0.6	0.7	-0.3	0.6
Distance traveled after self-admin	0.0	0.0	0.1	0.1	-0.3	0.1	0.1	0.1	-0.2
Extensor digitorum longus weight	0.1	0.3	0.5	-0.4	0.4	-0.5	-0.7	0.7	-0.3
Bone: elastic displacement	1.7	2.0	2.3	-1.4	-1.3	-1.4	-1.5	1.5	-1.3
Bone: elastic work	5.1	6.6	7.7	-2.6	-2.4	-2.6	-2.8	2.7	-2.4
Bone: endosteal estimation	2.2	4.8	7.4	-2.7	-1.7	-2.4	-2.1	2.2	-1.7
Bone: endosteal perimeter	1.7	3.7	5.0	-2.2	-1.8	-2.0	-1.6	2.1	-1.7
Epididymis fat weight	0.7	2.5	3.5	-1.3	-1.7	-1.4	-1.6	1.5	-1.9
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.5	0.8	0.5	0.6	-0.1	0.6
Delta time in open arm before/after self-admin	1.0	1.0	1.7	-1.2	-0.5	-1.2	-1.3	0.9	-0.6
Diff in mean of infusions in LGA sessions	0.0	0.1	0.2	0.0	-0.2	-0.0	-0.1	-0.4	-0.3
Delay discount exponential model param	1.6	1.8	2.3	-1.3	-1.3	-1.4	-1.5	1.3	-1.3
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.1	0.2	-0.2
Active lever presses in extinction session 6	0.5	0.5	0.9	-0.7	-1.0	-0.6	-0.7	0.6	-0.8
Bone: final force	0.6	1.0	1.5	-1.2	-1.0	-1.1	-0.9	0.8	-0.9
Bone: final moment	1.1	1.8	2.4	-1.6	-1.3	-1.4	-1.2	1.2	-1.2
Food consumed during 24 hour testing period	2.0	2.7	3.6	-1.9	-1.3	-1.7	-1.8	1.5	-1.6
Glucose	0.4	0.6	1.2	0.9	0.7	0.7	1.1	0.0	0.6
Heart weight	8.3	12.8	13.8	-3.7	-3.6	-3.7	-3.5	3.4	-3.7
Delay discount hyperbolic model param	1.3	1.4	1.7	-1.2	-1.2	-1.2	-1.3	1.1	-1.1
Intermittent access intake day 1-15 change	0.4	0.8	1.2	1.1	1.0	1.1	0.8	-0.3	1.0
Intermittent access intake escalation	0.5	1.1	1.4	1.2	1.1	1.2	0.8	-0.5	1.2
Intermittent access intake escalation 2	1.2	1.4	2.0	1.2	1.4	1.3	0.9	-0.9	1.3
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	-0.5	-0.5	-0.6	-0.4	0.0	-0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.5	0.2
Intermitt. access escalation Index	0.3	0.4	0.7	0.8	0.6	0.8	0.4	-0.6	0.7
Intermittent access day 1 total infusions	0.5	0.8	1.6	-0.8	-0.6	-0.9	-0.9	1.3	-0.9
Intermittent access day 15 total infusions	0.1	0.2	0.4	0.4	0.6	0.3	-0.1	0.4	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	1.0	0.3	1.0	0.3	-0.3	0.5	0.4
Intermittent access total infusions	0.3	0.3	1.1	-0.4	0.3	-0.4	-0.8	1.1	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	0.2	0.1	0.0	0.1	-0.1
Intermittent access day 15 total locomotion	0.1	0.3	0.6	-0.5	-0.1	-0.4	-0.8	0.8	-0.2
Intermittent access total locomotion	0.4	0.4	1.0	-0.6	0.1	-0.6	-0.9	1.0	-0.3
Intermittent access standard deviation	0.1	0.2	0.7	-0.2	0.1	-0.1	-0.5	0.8	-0.1
Left kidney weight	14.1	65.5	73.2	-8.0	-8.6	-7.9	-8.1	7.9	-8.1
Right kidney weight	16.1	73.5	84.6	-8.5	-8.8	-8.3	-9.2	8.3	-8.3
Cocaine induced anxiety	1.2	1.8	2.2	-1.5	-1.5	-1.5	-1.1	1.1	-1.3
Post-drug Anxiety	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.1	0.4	-0.5
Baseline Anxiety	2.3	2.6	3.5	1.9	1.5	1.8	1.8	-1.3	1.2
Tail length	0.1	0.4	0.8	0.8	0.2	0.9	0.8	-0.3	0.3
Length with tail	0.3	1.1	1.5	-0.8	-1.2	-0.9	-1.0	1.1	-1.2
Length without tail	0.8	2.6	3.9	-1.5	-1.6	-1.6	-2.0	1.2	-1.7
Times rat made contact with spout	1.6	1.8	2.6	-1.4	-1.0	-1.5	-1.4	1.1	-1.6
Lifetime Intake	0.6	0.7	2.1	-0.7	-0.2	-0.7	-1.1	1.5	-0.4
Liver weight, left	0.1	0.1	0.3	0.0	-0.6	0.0	-0.4	-0.1	-0.1
Liver weight, right	0.3	0.6	1.4	-0.5	-1.2	-0.6	-0.5	0.6	-0.9
Locomotor activity	2.6	4.1	4.8	-2.1	-2.2	-2.0	-1.8	2.2	-1.9
Locomotor testing distance	0.0	0.1	0.4	0.0	0.4	0.1	0.1	0.0	0.6
Locomotor testing rearing	0.3	0.6	0.9	-0.8	-0.8	-0.9	-0.9	0.7	-0.4
Locomotion in novel chamber	0.3	0.3	0.6	0.7	0.4	0.8	0.6	-0.6	0.2
Locomotion in novel chamber post-restriction	0.6	1.0	1.5	1.0	1.1	0.8	1.2	-0.7	1.2
Fecal boli incidents, locomotor time 1	0.0	0.0	0.2	0.1	0.1	-0.1	0.2	-0.0	0.4
Change in fecal boli incidents, locomotor task	0.6	0.5	0.9	-0.8	-1.0	-0.7	-0.5	0.3	-0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.1	-0.3	-0.5	-0.3	0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.5	0.1	0.3	0.1	0.1	0.2
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.7	0.4	0.5	0.3	0.0	0.4
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.1	-0.0	-0.1	-0.5	0.4	-0.3
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.2	-0.5	-0.2	0.1	-0.2	-0.4
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.6	0.7	0.7	0.8	0.7	-0.8	0.7
Bouts of movement, locomotor time 2	0.3	0.4	0.7	0.8	0.4	0.8	0.8	-0.5	0.4
Total resting periods, locomotor time 2	0.2	0.4	0.7	0.8	0.4	0.8	0.8	-0.5	0.3
Rest time, locomotor task time 2	0.1	0.1	0.3	0.5	0.2	0.5	0.3	-0.3	0.2
Distance moved, locomotor task time 2	0.6	0.7	1.0	-1.0	-0.8	-0.8	-0.8	0.5	-0.9
Vertical activity count, locomotor time 2	0.3	0.4	0.7	-0.8	-0.6	-0.7	-0.5	0.1	-0.6
Light reinforcement 1	0.3	0.7	1.1	-0.7	-0.8	-0.8	-0.9	1.1	-0.6
Light reinforcement 2	0.4	0.7	1.2	-0.6	-1.1	-0.6	-0.6	1.1	-0.9
Bone: marrow area	2.4	5.3	8.0	-2.8	-1.8	-2.6	-2.3	2.3	-1.8
Bone: maximum diameter	4.9	9.2	10.5	-3.2	-3.1	-3.1	-2.6	3.0	-3.0
Bone: maximum force	1.7	3.1	3.9	-2.0	-1.6	-1.9	-1.8	1.5	-1.7
Bone: maximum moment	2.5	4.4	5.4	-2.3	-2.0	-2.2	-2.1	1.9	-2.0
Mean time between licks in bursts	0.3	0.8	1.3	1.1	1.0	0.9	0.7	-0.4	1.2
Mean num. licks in bursts	1.2	1.9	2.4	-1.5	-0.9	-1.5	-1.5	1.2	-1.6
Cd content in liver	1.1	1.2	1.6	-1.2	-1.0	-1.2	-1.2	0.8	-1.0
Co content in liver	0.3	0.3	0.7	-0.4	-0.9	-0.4	-0.7	0.5	-0.5
Cu content in liver	7.5	8.9	10.2	3.1	2.7	3.2	3.0	-2.9	3.0
Fe content in liver	1.8	2.2	2.5	-1.6	-1.5	-1.5	-1.5	1.4	-1.5
K content in liver	1.5	1.4	2.2	1.4	0.7	1.5	1.0	-1.3	1.1
Mg content in liver	1.8	1.9	2.6	1.6	0.9	1.6	1.3	-1.3	1.3
Mn content in liver	0.1	0.1	0.1	0.3	-0.2	0.3	-0.1	-0.3	0.2
Na content in liver	1.3	1.4	1.7	1.3	1.2	1.3	1.1	-1.0	1.1
Rb content in liver	0.2	0.2	0.5	-0.3	-0.7	-0.3	-0.3	0.3	-0.5
Se content in liver	1.0	1.2	1.4	1.2	1.0	1.2	1.0	-1.2	1.2
Sr content in liver	2.2	1.9	2.3	1.5	1.5	1.3	1.4	-1.2	1.4
Zn content in liver	0.0	0.0	0.0	0.2	0.1	0.1	-0.0	-0.0	0.1
Bone: minimum diameter	0.4	0.6	0.9	-0.9	-0.9	-0.9	-0.6	0.8	-0.6
Time in familiar zone, hab. session 1	0.3	0.3	0.9	-0.5	-0.4	-0.6	-1.0	0.3	-0.3
Time in novel zone, hab. session 1	0.9	0.9	1.5	-0.8	-1.0	-0.9	-0.2	1.2	-1.1
Total zone transitions, hab. session 1	2.0	2.8	3.3	1.7	1.5	1.7	1.5	-1.8	1.7
Total locomotion distance, hab. session 1	0.4	0.6	0.9	0.9	0.7	1.0	0.6	-0.8	0.8
Locomotion velocity, hab. session 1	0.7	0.9	1.3	1.0	0.9	1.1	0.6	-1.0	1.0
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.5	-0.1	0.4	0.5	-0.1	0.2
Time in novel zone, hab. session 2	0.7	0.7	0.9	-1.0	-0.4	-0.9	-0.8	0.8	-0.9
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	-0.2	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.4	0.3	0.4	0.1	-0.3	0.5
Locomotion velocity, hab. session 2	0.3	0.5	0.7	0.7	0.6	0.8	0.4	-0.7	0.8
Novel to familiar place preference ratio	2.3	2.6	3.5	-1.5	-1.9	-1.4	-1.3	1.6	-1.7
Novelty place preference	3.1	3.4	4.7	-1.8	-2.2	-1.7	-1.6	1.8	-2.0
Time in novel zone, NPP test	4.5	4.8	6.1	-2.2	-2.5	-2.1	-1.9	2.1	-2.3
Total zone transitions, NPP test	0.5	0.7	1.3	0.6	1.0	0.8	0.2	-1.0	1.2
Total locomotion distance, NPP test	0.3	0.3	0.7	0.4	0.8	0.5	-0.1	-0.5	0.8
Locomotion velocity, NPP test	1.2	1.6	2.4	1.1	1.6	1.3	0.6	-1.3	1.6
Intraocular pressure	0.3	0.5	0.9	-0.8	-0.5	-0.8	-0.3	0.5	-0.9
Delta distance traveled before/after self-admin	1.6	1.7	2.3	-1.3	-1.4	-1.2	-1.3	1.0	-1.5
Delta ambulatory time before/after self-admin	2.0	2.4	3.5	-1.5	-1.9	-1.4	-1.5	1.0	-1.9
Parametrial fat weight	0.6	1.5	2.2	1.5	1.2	1.3	1.1	-1.5	0.8
Pavlov. Cond. lever latency	2.4	3.0	4.3	-1.8	-1.5	-1.8	-1.6	2.1	-1.7
Pavlov. Cond. magazine entry latency	2.7	3.5	5.4	1.9	1.6	1.8	1.9	-2.3	1.5
Pavlov. Cond. change in total contacts	3.4	3.6	5.6	1.9	1.6	1.9	1.9	-2.4	1.6
Pavlov. Cond. index score	2.4	3.1	4.3	1.8	1.5	1.8	1.8	-2.1	1.4
Pavlov. Cond. latency score	2.0	2.6	4.0	1.6	1.3	1.6	1.6	-2.0	1.4
Pavlov. Cond. lever contacts	4.6	5.5	7.1	2.4	2.1	2.4	2.3	-2.7	2.2
Pavlov. Cond. magazine entry number	3.2	4.0	6.0	-2.0	-1.8	-2.0	-2.1	2.5	-1.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.3	0.6	1.1	0.7	0.7	-0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	5.0	2.0	1.7	1.9	2.1	-2.2	1.6
Pavlov. Cond. response bias	4.9	6.1	7.9	2.5	2.2	2.5	2.6	-2.8	2.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	-0.3	-0.5	-0.5	0.2	-0.5
Pavlov. Cond. magazine entry latency	2.5	3.0	4.1	1.9	2.0	1.7	1.6	-1.3	1.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.6	0.1	0.4	0.2	-0.1	0.5
Pavlov. Cond. index score	1.1	1.5	2.1	1.5	1.2	1.3	1.3	-0.8	1.3
Pavlov. Cond. latency score	1.4	1.9	2.4	1.5	1.4	1.4	1.3	-1.0	1.5
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.8	0.4	0.6	0.7	-0.3	0.6
Pavlov. Cond. magazine entry number	1.8	2.2	2.6	-1.6	-1.6	-1.5	-1.4	1.2	-1.6
Pavlov. Cond. intertrial magazine entries	2.3	3.4	3.9	-1.8	-2.0	-1.9	-1.8	1.6	-1.9
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.3	1.5	1.2	1.4	1.3	-0.9	1.5
Pavlov. Cond. response bias	0.6	0.8	1.4	1.2	0.8	0.9	1.0	-0.5	0.9
Time in closed arm before self-admin	2.8	3.6	4.5	2.1	1.8	2.0	1.2	-2.1	2.0
Time in closed arm after self-admin	1.6	1.7	2.3	1.5	1.0	1.5	1.0	-1.4	1.3
Time in open arm before self-admin	0.2	0.2	0.8	0.2	0.5	0.2	0.9	-0.1	0.1
Time in open arm after self-admin	0.8	0.9	1.7	-1.1	-0.3	-1.2	-0.9	1.3	-0.6
Bone: periosteal estimation	2.1	4.5	5.9	-2.4	-2.1	-2.3	-1.9	2.1	-1.9
Bone: periosteal perimeter	3.0	5.1	6.2	-2.4	-2.5	-2.3	-1.8	2.4	-2.2
Bone: post-yield work	0.4	0.6	1.2	-1.1	-0.5	-1.0	-0.4	0.7	-0.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	-0.3	-0.1	-0.3	-0.3	0.7	-0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.3	-0.1	0.1	-0.1	-0.2	0.5	-0.1
Progressive ratio test 1 inactive lever presses	0.3	0.5	1.0	-0.6	-0.3	-0.7	-0.7	1.0	-0.5
Progressive ratio test 2 active lever presses	0.6	0.7	1.4	-0.7	-0.0	-0.7	-1.2	1.1	-0.7
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	-0.6	0.1	-0.7	-1.1	1.0	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.5	0.3	0.7	0.3	-0.2	-0.1	0.2
Incentive Sensitization - Responses	0.8	1.1	2.1	-1.0	-0.2	-1.0	-1.5	1.4	-0.8
Incentive Sensitization - Breakpoint	0.9	1.2	2.3	-1.0	-0.2	-1.0	-1.5	1.4	-0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	-0.1	-0.3	-0.4	-0.4	0.1
Progressive ratio	0.1	0.2	0.5	0.4	0.5	0.5	0.3	-0.7	0.2
Food seeking constrained by brief footshock	0.5	0.6	1.2	-0.6	-1.1	-0.7	-1.0	0.2	-0.9
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.4	-0.7	-0.6	-0.6	0.5	-0.4
Retroperitoneal fat weight	1.6	6.7	9.6	-2.3	-3.0	-2.4	-2.5	2.0	-3.1
Reaction time number correct	0.9	1.7	2.3	1.4	1.1	1.5	1.1	-1.2	1.4
Reaction time mean minus median	0.1	0.4	0.6	-0.6	-0.6	-0.6	-0.3	0.7	-0.8
Reaction time mean minus median AUC	0.4	1.1	1.7	-1.1	-0.8	-1.1	-1.0	1.3	-1.0
Reaction time num false alarms	0.0	0.1	0.1	-0.3	-0.2	-0.4	-0.3	-0.0	0.1
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.4	-0.2	-0.5	-0.4	0.1	0.0
Reaction time trials correct on left	0.9	1.7	2.3	1.4	1.1	1.5	1.1	-1.2	1.4
Reaction time trials on left	1.0	1.8	2.4	1.5	1.1	1.5	1.2	-1.2	1.5
Reaction time mean	0.0	0.1	0.2	0.4	-0.0	0.3	0.4	0.0	0.2
Reaction time mean AUC	0.0	0.1	0.2	0.4	-0.1	0.3	0.4	0.0	0.2
Median of all reaction times	0.2	0.2	0.4	0.7	0.2	0.5	0.6	-0.2	0.5
Reaction time omissions	0.1	0.1	0.3	0.2	0.2	0.3	0.5	-0.1	0.5
Reaction time false alarm rate	0.4	0.6	1.1	-0.9	-0.6	-1.0	-0.8	0.5	-0.6
Reaction time premature initiation rate	0.1	0.1	0.6	-0.0	0.2	-0.0	-0.7	-0.3	0.1
Reaction time premature initiations	0.2	0.3	0.4	0.6	0.6	0.6	-0.2	-0.6	0.6
Std. dev. reaction times	0.1	0.2	0.6	-0.2	-0.8	-0.3	-0.2	0.5	-0.4
Reaction time trials completed	1.0	1.8	2.4	1.5	1.1	1.5	1.2	-1.2	1.5
Reaction time trials AUC	0.7	1.4	1.9	1.3	0.9	1.4	1.0	-1.0	1.3
Run reversals in cocaine runway, females	2.2	2.2	3.2	1.7	1.1	1.7	1.8	-1.5	1.0
Run reversals in cocaine runway, males	1.7	1.7	2.3	-1.3	-1.3	-1.5	-1.2	0.9	-1.5
Latency to leave start box in cocaine runway	0.7	0.7	1.5	-0.9	-0.3	-0.9	-0.8	1.2	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.7	0.2	-0.6	-0.5	0.7	-0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.3	-0.8	-0.8	-0.8	-0.9	1.2	-0.9
Std. dev. time between licks in bursts	0.7	0.9	1.5	1.2	0.8	1.1	0.7	-0.9	1.0
Total sessions with >9 infusions	3.1	3.7	6.7	-1.8	-1.7	-1.9	-2.0	2.6	-1.5
Short access day 1 total inactive lever presses	3.3	4.4	5.5	-2.0	-2.0	-2.2	-2.4	2.2	-1.8
Short access day 10 total inactive lever presses	0.9	2.2	2.9	-1.6	-1.7	-1.5	-1.4	1.3	-1.5
Short access day 1 total infusions	2.0	2.6	3.9	-1.4	-1.5	-1.4	-1.7	2.0	-1.7
Short access day 10 total infusions	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.3	0.6	-0.1
Short access total infusions	1.9	2.5	4.2	-1.4	-1.4	-1.4	-1.6	2.1	-1.3
Short access day 1 locomotion	0.3	0.4	0.9	-0.5	-0.2	-0.7	-0.7	1.0	-0.3
Short access day 10 total locomotion	0.4	0.8	1.4	0.8	1.2	0.7	0.8	-0.6	1.2
Short access total locomotion	0.0	0.1	0.2	0.1	0.0	-0.0	0.0	0.5	0.3
One hour access (0.3 mA shock)	0.2	0.3	1.1	0.1	1.0	0.3	-0.2	0.1	0.7
Compulsive drug intake	0.2	0.2	0.6	-0.6	-0.1	-0.4	-0.2	-0.8	0.0
One hour access (shock baseline)	0.2	0.3	1.1	0.4	1.0	0.4	-0.1	0.5	0.6
Social response proportion	0.3	0.3	1.3	-0.1	0.1	-0.3	-0.2	1.2	-0.6
Social responses	0.3	0.4	0.6	0.8	0.4	0.6	0.8	-0.6	0.3
Social time	2.6	3.6	5.6	2.1	1.9	1.9	2.4	-1.1	1.8
Soleus weight	0.2	0.6	1.0	-1.0	-0.2	-1.0	-0.9	0.3	-0.7
Bone: stiffness	0.5	0.8	1.2	-1.1	-0.9	-1.0	-0.7	0.6	-0.9
Tibialis anterior weight	0.3	1.0	2.1	0.9	1.5	0.9	0.4	-0.9	1.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.3	-0.7	-0.5	-0.6	0.3	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.2	0.4	0.1	0.3	-0.3	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.2	-0.7	-0.3	0.1	-0.1	-0.5
Time to tail flick, test, after self-admin	1.0	1.0	1.8	0.8	1.3	0.7	0.8	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	-0.9	-0.4	-1.0	-0.8	0.8	-0.7
Delta time to tail flick, test, before/after SA	1.4	1.4	3.4	0.9	1.9	1.0	0.5	-1.1	1.4
Tibia length	0.7	1.9	2.7	-1.5	-1.4	-1.4	-1.6	0.9	-1.3
Ambulatory time before self-admin	0.1	0.1	0.2	0.4	0.3	0.2	0.5	0.3	0.3
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	-0.1	0.1	0.2	-0.3	-0.2
Bone: tissue strength	0.4	0.4	0.7	-0.8	-0.3	-0.7	-0.8	0.8	-0.5
Total heroin consumption	0.9	1.0	1.4	-1.1	-1.1	-1.2	-1.0	0.2	-1.1
Bone: trabecular number	0.2	0.4	0.8	0.5	0.9	0.4	0.9	-0.4	0.4
Bone: trabecular spacing	1.0	1.3	1.8	-1.1	-1.2	-1.0	-1.3	1.2	-1.0
Bone: trabecular thickness	0.6	0.8	1.4	1.2	0.5	1.0	1.0	-0.5	0.8
Bone: trabecular tissue density	1.0	1.4	1.9	1.2	1.3	1.4	0.7	-1.0	1.4
Water consumed over 24 hours	3.1	4.2	5.6	-2.3	-1.7	-2.2	-1.9	1.7	-2.4
Number of responses in last shaping day	0.8	0.9	1.2	1.1	0.9	1.0	1.0	-0.9	0.6