Hub : Genes

Scg3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Scg3 0.34 0.13 4.3e-07 0.3 0.3 0.32 0.31 8.2e-08 7.8e-08 2.9e-08 5.2e-08
2 IL gene expression Scg3 0.23 0.11 1.5e-04 0.1 0.12 0.09 0.08 2.1e-03 1.1e-03 3.0e-03 5.0e-03
3 Brain gene expression Scg3 0.16 0.08 2.1e-07 0.04 0.07 0.07 0.05 1.1e-04 2.9e-07 7.0e-07 1.2e-05
4 BLA mRNA stability Scg3 0.07 0.05 9.5e-04 0.06 0.06 0.05 0.04 3.0e-04 6.1e-04 1.3e-03 3.6e-03
5 NAcc mRNA stability Scg3 0.03 0.02 1.1e-05 0.03 0.03 0.03 0.03 7.0e-06 2.1e-05 1.8e-05 3.7e-05
6 NAcc gene expression Scg3 0.08 0.04 2.5e-09 0.05 0.06 0.05 0.06 2.2e-08 3.6e-09 1.2e-08 3.4e-09
7 IC gene expression Scg3 0.35 0.13 2.9e-08 0.07 0.21 0.17 0.16 4.7e-04 4.3e-09 1.8e-07 4.4e-07
8 Brain mRNA stability Scg3 0.21 0.08 0.0e+00 0.17 0.24 0.24 0.23 4.0e-16 3.9e-22 4.5e-22 1.2e-21
9 PL mRNA stability Scg3 0.07 0.04 1.0e-06 0.02 0.05 0.05 0.04 9.8e-04 4.0e-06 8.5e-06 4.1e-05
10 PL gene expression Scg3 0.12 0.06 4.9e-10 0.07 0.08 0.08 0.07 9.0e-08 3.4e-09 1.2e-08 1.2e-08
11 BLA gene expression Scg3 0.1 0.06 8.4e-03 0 0.01 0.01 0.01 1.9e-01 4.9e-02 1.5e-01 6.7e-02
12 Adipose gene expression Scg3 0.04 0.03 2.0e-03 0.02 0.01 0.01 0.01 1.1e-03 2.6e-02 2.9e-02 8.6e-03
13 Eye gene expression Scg3 0.5 0.17 1.7e-04 0.06 0.12 0.06 0.08 4.1e-02 7.5e-03 5.0e-02 2.2e-02
14 Liver gene expression Scg3 0.02 0.01 5.8e-03 -0 0 -0 -0 5.3e-01 2.2e-01 7.6e-01 9.4e-01
15 IC mRNA stability Scg3 0.09 0.06 2.4e-03 0.04 0.06 0.04 0.02 1.3e-02 1.7e-03 1.4e-02 4.8e-02
16 pVTA gene expression Scg3 0.21 0.1 1.6e-11 0.17 0.12 0.15 0.14 1.9e-13 1.1e-09 3.0e-12 2.3e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.10.20.9-0.5-0.00.40.1-0.1-0.3-0.1-0.3-0.30.2-0.10.90.40.4-0.50.9
Area under the delay curve1.11.32.21.21.31.2-1.2-1.31.31.5-1.0-0.91.51.4-1.01.00.7-0.00.6
BMI with tail2.06.917.33.72.81.9-2.3-2.74.23.7-1.8-1.62.83.5-3.41.30.70.8-0.9
BMI without tail1.13.59.21.81.52.5-1.0-2.03.02.9-1.0-1.02.43.0-1.61.10.30.9-0.4
Body weight1.98.324.83.92.42.6-1.9-2.45.04.5-1.2-1.22.94.3-3.90.7-0.21.9-1.6
Weight adjusted by age1.21.83.21.61.61.1-1.7-1.31.01.4-1.5-1.81.31.0-1.11.21.3-1.00.9
Bone surface1.62.94.91.11.91.3-1.7-2.10.71.0-2.2-2.11.70.70.72.22.2-1.82.1
Bone volume0.71.32.10.81.21.1-1.1-1.30.70.9-1.4-1.41.30.80.41.41.3-1.01.5
Breakpoint value in progressive ratio session1.11.42.61.21.40.7-1.3-1.60.80.8-1.5-1.61.00.50.01.31.4-1.31.0
Number of licking bursts1.42.34.31.41.91.1-1.9-1.81.11.4-2.0-2.11.40.9-0.41.61.8-1.41.0
Context. condit. distance diff. score0.40.41.10.70.9-0.5-1.1-0.60.0-0.1-0.8-0.80.3-0.2-0.50.60.9-0.90.3
Locomotion velocity, session 10.50.61.60.40.61.1-0.4-0.71.11.1-0.4-0.21.11.3-0.70.60.10.5-0.1
Locomotion distance, session 10.40.63.2-1.2-0.61.50.9-0.3-0.20.20.0-0.20.30.31.80.30.1-0.20.8
Locomotion velocity, session 20.81.02.10.41.01.4-0.6-1.31.01.0-0.9-0.91.51.20.11.20.8-0.31.1
Locomotion distance, session 20.81.16.4-0.6-0.22.50.8-1.01.11.3-0.1-0.21.41.61.30.7-0.20.60.4
Locomotion velocity, session 31.92.27.9-1.20.40.7-0.1-1.0-1.1-0.9-1.2-1.10.6-0.82.71.81.8-2.02.8
Locomotion distance, session 31.71.88.7-2.3-1.10.21.50.4-1.8-1.60.40.4-0.5-1.22.90.40.3-0.81.6
Stereotopy head waving bouts, day 31.01.14.00.10.1-2.0-0.60.7-1.6-1.4-0.3-0.5-1.4-1.90.2-0.20.7-1.40.5
Stereotopy head waving duration, day 30.80.94.80.70.5-2.2-1.00.7-1.0-1.0-0.4-0.3-1.1-1.5-0.7-0.20.6-1.0-0.1
Locomotion velocity, session 70.10.10.5-0.4-0.20.00.20.2-0.7-0.6-0.0-0.1-0.1-0.50.60.20.3-0.50.3
Locomotion distance, session 70.20.30.80.00.30.8-0.1-0.70.10.1-0.6-0.60.60.20.60.80.7-0.60.9
Stereotopy head waving bouts, day 71.11.33.5-0.60.7-0.4-0.6-0.5-1.2-1.1-1.1-0.90.3-1.11.71.51.7-1.91.3
Stereotopy head waving duration, day 71.01.23.0-0.60.8-0.1-0.6-0.6-0.9-0.8-1.2-0.80.5-0.81.71.61.6-1.71.5
Locomotion velocity, session 81.01.23.3-0.50.91.3-0.4-1.30.20.3-1.2-0.91.50.61.41.81.3-1.01.6
Locomotion distance, session 80.91.33.1-0.10.81.8-0.4-1.50.50.7-1.2-1.21.40.81.31.51.2-0.91.3
Degree of sensitization distance1.21.24.62.01.10.3-1.3-0.71.51.4-0.6-0.70.71.1-2.10.00.10.3-0.8
Degree of sensitization stereotypy1.01.12.9-0.60.70.1-0.5-0.6-0.8-0.7-1.1-0.80.6-0.61.71.51.5-1.61.5
Conditioned locomotion0.81.02.9-0.1-1.00.20.80.90.30.51.20.8-0.60.4-1.0-1.5-1.51.4-1.7
Cocaine response after cond. corrected0.91.12.81.61.6-0.2-1.7-1.01.00.8-1.2-1.01.00.6-1.31.01.0-0.5-0.0
Cocaine response after cond. not corrected1.51.74.92.21.8-0.3-2.1-0.91.51.3-1.2-1.00.90.9-2.20.60.8-0.2-0.8
Cocaine response before conditioning1.11.33.31.81.10.7-1.2-0.81.71.8-0.6-0.80.81.4-1.80.10.10.5-1.1
Saline control response1.01.34.1-0.4-0.1-2.0-0.10.6-1.7-1.9-0.2-0.0-1.2-2.01.00.00.7-1.40.9
Bone: connectivity density0.71.15.9-1.8-0.90.51.00.3-1.3-0.90.2-0.0-0.4-0.82.40.20.2-0.71.5
Bone: cortical apparent density2.33.25.7-1.8-2.0-1.71.92.4-1.5-1.72.22.4-1.9-1.30.3-1.9-1.91.4-1.0
Bone: cortical area0.50.73.60.90.3-1.9-0.80.5-0.8-0.9-0.2-0.3-1.1-1.4-0.6-0.40.4-0.90.2
Bone: cortical porosity0.40.41.4-0.2-0.7-0.70.30.7-0.8-0.50.40.0-1.2-0.9-0.1-1.0-0.4-0.2-0.6
Bone: cortical porosity0.40.41.4-0.3-0.7-0.70.30.6-1.0-0.70.3-0.1-1.2-1.10.2-0.8-0.2-0.5-0.2
Bone: cortical thickness2.54.18.6-1.1-2.0-2.91.42.7-2.1-2.32.12.1-2.8-2.3-0.2-2.3-1.70.8-1.2
Bone: cortical thickness1.11.33.60.2-0.7-1.90.21.5-0.6-0.81.11.1-1.5-0.9-1.5-1.6-1.10.8-1.2
Bone: cortical tissue density2.12.95.3-1.8-2.0-1.51.92.3-1.4-1.62.12.3-1.7-1.20.4-1.8-1.91.4-0.9
Condit. Reinf. active minus inactive responses1.31.45.9-0.40.32.40.4-1.11.61.6-0.10.01.82.10.00.8-0.21.0-0.6
Condit. Reinf. active-inactive response ratio0.30.31.70.50.4-0.4-0.4-0.10.60.20.10.30.30.4-1.30.0-0.20.5-1.0
Condit. Reinf. active responses1.92.410.8-0.50.73.30.1-1.81.71.9-0.8-0.72.52.40.91.70.50.40.3
Condit. Reinf. inactive responses1.51.98.3-0.60.52.90.1-1.50.91.4-0.9-1.01.91.61.71.60.8-0.31.3
Incentive salience index mean1.62.06.60.41.02.6-0.7-1.81.82.0-1.1-1.31.92.0-0.01.20.7-0.10.1
Condit. Reinf. lever presses1.72.36.81.01.41.9-1.5-2.01.21.9-1.9-2.61.21.10.21.11.5-1.41.0
Condit. Reinf. active minus inactive responses0.70.92.60.71.4-0.1-1.2-0.90.30.0-1.1-0.51.20.30.01.61.3-0.71.4
Condit. Reinf. active-inactive response ratio0.60.61.60.10.7-1.3-0.80.1-0.8-1.1-0.6-0.1-0.1-1.00.50.91.0-1.01.2
Condit. Reinf. active responses1.21.73.61.51.61.1-1.2-1.51.81.5-1.1-0.71.91.7-1.01.40.80.10.4
Condit. Reinf. inactive responses1.72.26.21.40.92.2-0.7-1.42.42.5-0.6-0.71.72.4-1.40.5-0.11.0-1.1
Condit. Reinf. lever presses1.11.53.81.81.8-0.9-1.9-1.00.50.2-1.5-1.30.6-0.1-1.01.11.5-1.30.7
Condit. Reinf. lever reinforcers received1.01.32.81.41.40.9-1.1-1.21.61.4-0.9-0.51.71.6-1.11.20.60.30.2
Conditioned reinforcement - actives0.30.51.71.30.8-0.3-0.9-0.50.70.7-0.8-1.0-0.10.0-0.30.00.5-0.60.7
Conditioned reinforcement - inactives0.10.10.30.50.20.30.0-0.30.60.5-0.1-0.10.20.4-0.10.0-0.00.2-0.0
Conditioned locomotion0.50.61.50.2-0.7-0.50.50.90.20.01.00.8-0.70.0-0.9-1.2-1.11.0-1.2
Patch foraging indifference point 0 sec0.20.30.80.20.8-0.3-0.7-0.40.0-0.2-0.7-0.40.4-0.20.30.90.9-0.70.8
Patch foraging indifference point AUC0.81.13.1-0.8-1.01.81.30.10.91.20.90.50.31.30.1-0.8-1.31.5-1.2
Delay disc. indifference point, 0s delay0.80.84.2-0.8-0.02.10.6-0.70.80.9-0.10.11.41.41.10.8-0.00.60.3
Delay disc. indifference point, 16s delay0.10.21.10.4-0.0-0.3-0.20.20.00.10.30.4-0.10.1-1.0-0.4-0.40.5-0.4
Delay disc. indifference point, 2s delay0.60.71.70.70.71.0-0.5-0.81.21.1-0.4-0.21.21.3-0.80.70.10.5-0.0
Delay disc. indifference point, 24s delay0.10.10.30.20.20.4-0.3-0.20.20.4-0.1-0.10.40.4-0.40.20.00.20.5
Delay disc. indifference point, 4s delay1.01.02.20.61.11.3-1.0-1.30.91.1-1.0-0.91.51.2-0.11.30.8-0.31.2
Delay disc. indifference point, 8s delay2.93.46.02.02.12.0-1.8-2.22.42.4-1.7-1.62.32.3-1.51.61.1-0.10.7
Indifference point function ln k0.71.22.60.81.3-1.4-1.5-0.4-0.6-0.9-1.2-0.80.1-1.00.11.21.5-1.51.6
Indifference point function log k0.71.22.60.81.3-1.4-1.5-0.4-0.6-0.9-1.2-0.80.1-1.00.11.21.5-1.51.6
Patch foraging total patch changes 0 sec0.10.10.30.20.5-0.4-0.5-0.20.0-0.2-0.4-0.10.2-0.1-0.00.50.5-0.40.5
Patch foraging total patch changes 12 sec0.40.51.3-0.9-1.10.51.10.7-0.10.10.90.6-0.40.20.4-0.9-1.00.8-0.8
Patch foraging total patch changes 18 sec0.20.30.7-0.2-0.5-0.70.50.7-0.2-0.40.60.5-0.8-0.4-0.3-0.8-0.60.3-0.8
Patch foraging total patch changes 24 sec0.30.61.5-1.1-0.51.21.10.00.50.30.50.90.90.90.80.4-0.51.0-0.5
Patch foraging total patch changes 6 sec0.40.52.4-1.4-0.61.21.00.1-0.1-0.10.30.50.60.51.50.5-0.20.30.4
Patch foraging time to switch 0 sec0.30.61.7-0.6-0.7-0.80.40.6-1.3-1.10.20.0-1.1-1.30.9-0.50.0-0.70.3
Patch foraging water rate 0 sec0.51.02.31.21.30.3-1.1-0.81.41.0-0.7-0.21.41.2-1.51.00.40.4-0.2
Patch foraging water rate 12 sec0.61.33.60.91.70.5-1.3-1.11.10.7-1.4-0.71.81.0-0.51.91.3-0.50.7
Patch foraging water rate 18 sec0.40.62.4-0.5-0.4-0.20.60.90.1-0.21.01.60.30.4-0.5-0.2-0.91.4-1.1
Patch foraging water rate 24 sec0.10.20.6-0.8-0.1-0.10.20.5-0.4-0.40.20.70.3-0.00.40.4-0.00.3-0.0
Patch foraging water rate 6 sec1.01.53.31.01.70.7-1.3-1.51.10.8-1.4-0.91.71.0-0.31.81.4-0.60.9
Seeking ratio, delayed vs. immediate footshock4.15.08.22.32.71.9-2.3-2.92.01.9-2.7-2.72.51.7-0.52.62.4-1.72.1
Distance traveled before self-admin1.52.03.80.81.70.8-1.5-1.60.60.7-1.9-1.71.40.50.61.91.9-1.61.8
Distance traveled after self-admin2.22.74.92.12.20.3-2.1-1.91.31.2-2.2-2.21.20.6-0.81.61.9-1.61.6
Extensor digitorum longus weight1.24.59.41.82.03.1-1.4-2.82.72.7-1.9-1.73.12.9-0.22.31.3-0.10.7
Bone: elastic displacement0.80.92.7-0.6-1.00.31.20.90.30.21.31.3-0.20.5-0.2-1.0-1.51.6-1.1
Bone: elastic work0.30.41.0-0.5-0.7-0.40.70.9-0.2-0.30.91.0-0.5-0.1-0.3-0.8-0.90.9-0.7
Bone: endosteal estimation3.47.413.23.03.51.4-3.5-3.31.82.0-3.6-3.62.41.3-0.63.03.3-2.72.2
Bone: endosteal perimeter2.04.37.62.42.51.3-2.6-2.51.51.8-2.6-2.81.91.2-0.52.12.3-1.81.8
Epididymis fat weight1.45.010.8-3.0-3.10.93.32.4-0.9-0.52.92.7-1.10.11.6-2.1-2.92.6-1.7
Delta time in closed arm before/after self-admin1.41.32.2-0.5-1.2-0.91.01.4-0.5-0.61.51.5-1.1-0.5-0.9-1.5-1.51.3-1.2
Delta time in open arm before/after self-admin2.22.27.2-1.5-0.4-1.40.40.4-2.2-2.2-0.2-0.0-1.0-2.22.70.51.0-1.71.8
Diff in mean of infusions in LGA sessions2.02.45.62.42.00.5-2.1-1.81.81.6-1.8-2.01.01.0-1.51.01.3-1.00.4
Delay discount exponential model param1.41.52.6-1.3-1.4-1.21.31.4-1.4-1.51.11.0-1.6-1.51.0-1.2-0.80.2-0.9
Extinction: sum of active levers before priming0.30.41.00.70.7-0.3-0.8-0.6-0.00.0-0.8-0.90.1-0.3-0.10.50.9-1.00.5
Active lever presses in extinction session 61.61.62.80.81.50.7-1.4-1.60.80.7-1.7-1.51.30.50.41.71.6-1.31.4
Bone: final force0.10.20.70.80.6-0.3-0.9-0.30.30.3-0.5-0.50.10.1-0.70.20.4-0.30.2
Bone: final moment0.10.20.70.50.2-0.8-0.60.20.0-0.1-0.0-0.0-0.4-0.3-0.8-0.3-0.0-0.1-0.2
Food consumed during 24 hour testing period2.93.911.33.42.8-0.3-3.1-1.91.91.7-2.1-2.01.31.1-2.81.21.6-1.00.3
Glucose0.00.10.4-0.6-0.1-0.20.30.2-0.3-0.40.10.2-0.1-0.20.40.10.0-0.00.2
Heart weight0.91.33.90.60.72.0-0.1-1.21.81.7-0.5-0.31.72.0-0.00.90.10.70.3
Delay discount hyperbolic model param1.41.52.7-1.3-1.4-1.31.31.4-1.5-1.61.11.0-1.6-1.61.1-1.1-0.70.0-0.7
Intermittent access intake day 1-15 change1.02.16.71.61.41.7-0.9-1.72.62.3-1.2-1.21.52.0-0.70.80.50.30.1
Intermittent access intake escalation1.02.06.21.41.31.8-0.8-1.62.52.3-1.1-1.11.62.0-0.50.80.40.30.1
Intermittent access intake escalation 23.03.57.51.92.12.0-1.5-2.32.72.5-1.9-1.92.22.2-0.51.61.3-0.40.7
Intermitt. access day 1 inactive lever presses0.20.91.7-0.4-0.9-1.10.51.1-1.0-1.01.00.9-1.1-0.9-0.8-1.1-0.80.4-1.3
Intermitt. access day 15 inactive lever presses0.40.72.2-0.8-1.00.90.80.20.30.31.10.90.10.7-0.2-0.7-1.21.3-1.5
Intermitt. access escalation Index0.60.84.31.30.9-0.5-0.90.21.31.3-0.3-0.10.20.8-2.1-0.3-0.20.7-0.9
Intermittent access day 1 total infusions0.30.51.7-0.0-0.7-1.00.21.0-0.8-0.50.60.2-1.3-0.9-0.4-1.2-0.60.0-0.2
Intermittent access day 15 total infusions0.10.20.80.70.20.2-0.3-0.10.70.9-0.2-0.5-0.20.4-0.6-0.5-0.20.1-0.2
Intermittent access terminal intake (last 3 days)0.50.62.21.50.70.3-0.8-0.61.21.2-0.6-0.90.20.7-1.2-0.20.2-0.1-0.4
Intermittent access total infusions0.20.30.60.80.2-0.7-0.60.2-0.10.2-0.3-0.7-0.8-0.5-0.7-0.60.1-0.5-0.1
Intermittent access day 1 locomotion0.81.12.9-0.3-1.2-0.70.81.4-0.4-0.21.31.0-1.2-0.4-0.9-1.7-1.41.1-0.9
Intermittent access day 15 total locomotion0.20.51.10.2-0.6-0.70.50.8-0.4-0.40.70.4-0.9-0.5-0.9-1.0-0.70.4-1.0
Intermittent access total locomotion0.20.31.51.10.4-0.5-0.6-0.10.20.2-0.3-0.4-0.2-0.1-1.2-0.20.2-0.3-0.3
Intermittent access standard deviation0.20.31.00.70.20.8-0.1-0.61.01.0-0.2-0.60.20.8-0.6-0.3-0.10.2-0.6
Left kidney weight0.52.17.62.31.20.4-1.1-0.82.41.9-0.4-0.30.91.8-2.8-0.1-0.41.1-1.5
Right kidney weight0.31.44.31.50.91.0-0.5-0.92.11.7-0.3-0.21.21.8-1.70.3-0.21.0-1.0
Cocaine induced anxiety0.10.10.40.00.0-0.2-0.1-0.1-0.3-0.1-0.3-0.5-0.4-0.40.5-0.10.3-0.60.6
Post-drug Anxiety0.20.21.5-0.7-0.40.10.40.1-0.7-0.50.0-0.0-0.2-0.51.20.10.1-0.40.4
Baseline Anxiety0.81.03.1-1.8-1.10.21.40.8-0.8-0.91.11.4-0.0-0.21.5-0.0-0.70.8-0.3
Tail length0.20.82.9-0.3-0.41.70.6-0.11.21.20.50.40.81.5-0.0-0.1-0.81.3-0.0
Length with tail0.41.75.40.80.31.90.1-0.62.32.10.10.21.42.3-0.90.1-0.81.7-0.6
Length without tail1.44.512.92.92.11.5-1.9-1.83.63.1-1.2-1.02.22.9-2.90.90.21.1-1.0
Times rat made contact with spout1.11.33.51.81.6-0.3-1.9-1.01.00.9-1.2-1.10.70.5-1.90.71.0-0.6-0.1
Lifetime Intake0.20.20.80.5-0.0-0.6-0.40.3-0.30.0-0.1-0.6-0.9-0.6-0.4-0.70.0-0.50.0
Liver weight, left0.30.51.71.00.50.5-0.3-0.41.31.2-0.10.00.61.1-1.0-0.1-0.40.8-0.1
Liver weight, right0.71.33.81.30.71.1-0.6-0.92.01.8-0.2-0.11.21.8-1.60.1-0.41.1-0.7
Locomotor activity0.10.20.70.50.40.0-0.70.10.50.8-0.2-0.30.10.4-0.8-0.1-0.00.3-0.5
Locomotor testing distance0.10.10.40.20.3-0.5-0.60.30.10.1-0.10.10.0-0.0-0.60.10.10.1-0.6
Locomotor testing rearing0.00.10.3-0.30.1-0.3-0.30.4-0.00.00.10.40.20.1-0.30.2-0.10.3-0.5
Locomotion in novel chamber0.10.10.30.10.1-0.5-0.20.1-0.5-0.5-0.2-0.2-0.3-0.6-0.40.00.3-0.50.5
Locomotion in novel chamber post-restriction0.20.30.8-0.4-0.70.20.90.20.3-0.00.70.8-0.20.20.3-0.6-0.90.9-0.6
Fecal boli incidents, locomotor time 11.31.85.11.61.11.8-1.2-1.32.02.3-0.9-1.31.41.9-1.40.40.30.3-0.3
Change in fecal boli incidents, locomotor task2.02.04.7-0.20.7-2.1-0.70.0-1.7-2.0-0.9-0.6-0.8-2.21.20.91.6-2.21.7
Time >=10cm from walls, locomotor time 10.60.71.80.80.90.6-0.9-0.90.40.7-1.1-1.30.50.30.00.71.0-0.90.9
Bouts of movement, locomotor time 10.50.51.60.60.31.1-0.5-0.71.11.3-0.1-0.20.81.2-0.80.1-0.20.6-0.2
Total resting periods, locomotor time 10.30.41.00.70.30.7-0.6-0.50.91.0-0.1-0.20.60.9-0.90.0-0.10.4-0.2
Rest time, locomotor task time 11.01.27.51.60.7-0.5-0.9-0.11.41.00.10.30.40.9-2.7-0.4-0.51.1-1.6
Distance moved, locomotor task time 10.40.62.5-1.6-1.00.71.40.5-0.4-0.30.60.6-0.00.01.6-0.1-0.50.40.3
Vertical activity count, locomotor time 10.10.31.3-1.1-0.70.50.90.3-0.5-0.20.40.3-0.1-0.11.1-0.2-0.30.20.2
Time >=10cm from walls, locomotor time 20.20.31.40.6-0.1-0.60.10.30.40.20.40.2-0.6-0.0-1.2-0.9-0.60.5-0.9
Bouts of movement, locomotor time 20.61.02.6-0.8-1.11.31.30.40.60.61.21.00.21.0-0.0-0.8-1.41.6-1.2
Total resting periods, locomotor time 20.40.71.8-0.6-0.91.11.00.20.50.60.90.80.20.9-0.1-0.6-1.21.3-1.0
Rest time, locomotor task time 21.11.42.5-0.5-1.2-1.60.81.4-0.9-1.11.31.3-1.5-1.1-0.4-1.5-1.20.7-1.3
Distance moved, locomotor task time 20.60.72.6-0.60.31.60.3-0.80.60.7-0.4-0.21.31.01.01.10.40.10.9
Vertical activity count, locomotor time 20.20.30.60.30.40.8-0.2-0.60.70.8-0.5-0.50.70.7-0.10.40.30.00.3
Light reinforcement 11.53.810.51.91.62.5-1.3-1.73.23.2-1.0-1.12.33.1-1.90.90.11.1-0.6
Light reinforcement 20.40.62.50.60.1-1.6-0.70.5-0.8-0.6-0.2-0.6-1.4-1.3-0.6-0.90.2-0.9-0.2
Bone: marrow area3.37.313.13.03.51.2-3.5-3.21.82.0-3.6-3.62.31.3-0.72.93.3-2.62.1
Bone: maximum diameter3.97.314.93.83.60.6-3.9-3.02.02.1-3.4-3.42.21.3-1.72.53.0-2.31.7
Bone: maximum force0.30.51.31.00.9-0.2-1.1-0.70.40.4-0.9-0.90.30.1-0.60.50.8-0.70.3
Bone: maximum moment0.10.20.80.80.6-0.6-0.9-0.20.10.1-0.5-0.6-0.2-0.3-0.70.10.5-0.5-0.1
Mean time between licks in bursts0.10.20.90.1-0.5-0.50.20.5-0.2-0.00.40.1-0.8-0.4-0.3-0.9-0.50.2-0.9
Mean num. licks in bursts0.71.02.2-0.2-0.8-1.20.71.2-0.3-0.71.31.5-0.9-0.4-1.1-1.2-1.31.2-1.2
Cd content in liver1.71.95.4-1.4-1.41.72.00.50.80.61.61.90.71.40.6-0.5-1.82.3-0.8
Co content in liver1.61.96.40.1-1.00.71.00.81.31.11.51.50.01.4-1.4-1.4-2.12.5-1.6
Cu content in liver0.10.10.20.40.10.0-0.1-0.10.40.30.1-0.0-0.00.2-0.5-0.3-0.20.3-0.4
Fe content in liver3.94.711.40.72.00.4-1.8-1.9-0.8-0.5-2.7-2.51.2-0.82.42.93.2-3.33.4
K content in liver0.00.00.1-0.00.00.10.1-0.40.1-0.2-0.00.10.20.00.30.30.1-0.10.1
Mg content in liver0.40.40.80.50.80.3-0.7-0.90.50.3-0.7-0.50.80.4-0.20.90.7-0.40.5
Mn content in liver0.91.04.00.4-0.1-2.0-0.60.6-1.2-1.1-0.1-0.5-1.7-1.7-0.5-0.90.2-1.10.0
Na content in liver1.92.14.30.31.21.1-1.1-1.7-0.00.2-1.8-2.01.10.01.51.82.0-2.11.9
Rb content in liver0.91.02.90.31.00.7-0.5-1.20.1-0.1-1.1-0.81.20.21.11.71.4-1.11.5
Se content in liver0.81.02.9-0.7-0.4-1.20.20.5-1.7-1.7-0.0-0.0-1.0-1.71.30.00.5-1.20.9
Sr content in liver0.10.10.5-0.2-0.10.70.1-0.30.10.4-0.2-0.50.10.20.40.00.1-0.20.2
Zn content in liver1.01.12.2-0.7-1.3-0.41.31.2-0.3-0.51.51.4-0.9-0.3-0.2-1.4-1.51.3-0.5
Bone: minimum diameter0.20.31.51.20.4-0.8-0.80.10.20.2-0.2-0.3-0.5-0.2-1.1-0.50.0-0.1-0.3
Time in familiar zone, hab. session 11.51.43.31.31.40.8-1.5-1.40.81.1-1.6-1.81.00.7-0.31.11.4-1.20.7
Time in novel zone, hab. session 11.61.64.2-0.8-1.1-1.11.11.4-0.3-0.81.62.0-0.8-0.3-0.7-1.2-1.61.7-1.6
Total zone transitions, hab. session 10.91.34.6-2.1-1.51.61.90.3-0.3-0.11.00.80.10.42.1-0.3-0.90.80.4
Total locomotion distance, hab. session 11.52.17.6-2.8-1.91.62.40.9-0.5-0.31.51.4-0.00.32.2-0.5-1.31.20.3
Locomotion velocity, hab. session 10.91.35.2-2.3-1.51.41.90.6-0.5-0.21.00.8-0.00.22.1-0.3-0.80.70.6
Time in familiar zone, hab. session 20.10.10.30.20.5-0.3-0.6-0.30.0-0.2-0.4-0.20.3-0.1-0.30.50.5-0.30.0
Time in novel zone, hab. session 20.10.10.40.1-0.1-0.6-0.10.3-0.3-0.30.10.1-0.5-0.4-0.3-0.4-0.1-0.0-0.0
Total zone transitions, hab. session 21.21.58.2-1.5-0.82.91.4-0.70.81.10.30.21.21.61.80.4-0.50.90.1
Total locomotion distance, hab. session 21.31.77.9-1.8-1.22.81.8-0.20.61.10.80.50.91.51.8-0.1-1.01.2-0.2
Locomotion velocity, hab. session 21.21.56.1-1.9-1.42.51.90.10.30.90.90.50.41.21.8-0.4-1.11.1-0.3
Novel to familiar place preference ratio0.30.30.80.80.60.4-0.5-0.60.90.8-0.4-0.40.60.8-0.60.20.20.1-0.3
Novelty place preference0.70.71.61.31.10.4-1.0-0.91.21.1-0.7-0.70.81.0-1.10.40.40.0-0.3
Time in novel zone, NPP test0.91.02.41.61.40.1-1.4-1.01.31.1-1.0-0.80.90.9-1.40.70.6-0.1-0.2
Total zone transitions, NPP test0.60.84.2-0.9-0.22.10.7-0.80.60.7-0.1-0.11.21.11.30.80.10.30.8
Total locomotion distance, NPP test0.81.16.7-1.1-0.42.61.0-0.70.71.10.0-0.11.21.41.60.6-0.10.50.7
Locomotion velocity, NPP test0.91.36.8-1.6-0.92.61.5-0.40.10.70.2-0.00.91.02.30.4-0.30.30.9
Intraocular pressure0.20.31.10.40.10.00.30.10.80.30.40.80.50.7-0.7-0.0-0.61.1-0.8
Delta distance traveled before/after self-admin0.60.73.91.40.4-0.4-0.4-0.11.20.80.10.1-0.10.6-2.0-0.6-0.50.8-0.7
Delta ambulatory time before/after self-admin0.60.74.61.50.4-1.0-0.50.10.90.50.10.1-0.40.2-2.1-0.7-0.40.5-0.6
Parametrial fat weight0.92.24.6-1.4-2.00.32.01.7-0.20.11.91.6-1.10.10.3-1.9-2.11.8-1.4
Pavlov. Cond. lever latency2.12.75.8-1.1-1.4-2.41.22.3-1.5-2.01.82.3-1.7-1.6-0.4-1.4-1.41.1-1.0
Pavlov. Cond. magazine entry latency0.30.42.4-0.1-0.41.50.3-0.40.51.2-0.1-0.80.00.70.3-0.5-0.30.10.0
Pavlov. Cond. change in total contacts0.60.63.10.20.01.80.0-0.81.11.5-0.2-0.80.61.2-0.2-0.1-0.20.3-0.5
Pavlov. Cond. index score0.70.94.70.20.22.2-0.1-1.21.01.6-0.7-1.40.71.20.50.20.3-0.30.4
Pavlov. Cond. latency score0.81.04.40.30.32.1-0.2-1.31.01.6-0.8-1.50.81.20.50.40.5-0.40.4
Pavlov. Cond. lever contacts1.41.64.40.91.02.1-0.9-1.81.41.9-1.3-1.91.21.40.10.80.9-0.70.6
Pavlov. Cond. magazine entry number0.30.32.10.30.4-1.5-0.50.4-0.5-1.0-0.00.6-0.1-0.7-0.30.40.3-0.2-0.2
Pavlov. Cond. intertrial magazine entries0.80.93.4-0.90.61.30.1-1.00.20.0-0.7-0.11.60.71.51.80.9-0.40.7
Pavlov. Cond. lever-magazine prob. diff.0.91.15.50.20.22.3-0.2-1.31.01.7-0.8-1.60.81.30.50.30.4-0.40.5
Pavlov. Cond. response bias0.60.84.10.20.12.0-0.1-1.11.01.6-0.6-1.20.71.20.20.10.2-0.20.4
Pavlov. Cond. lever latency1.92.54.8-1.9-2.2-0.52.11.8-1.2-1.22.01.9-1.6-0.90.6-1.8-1.91.3-1.3
Pavlov. Cond. magazine entry latency1.01.23.6-0.8-0.8-1.40.41.1-1.8-1.50.30.0-1.6-1.91.0-0.70.1-1.00.7
Pavlov. Cond. change in total contacts0.20.30.50.70.7-0.1-0.7-0.40.10.2-0.6-0.50.40.1-0.10.60.6-0.50.7
Pavlov. Cond. index score0.60.82.00.71.0-0.3-1.1-0.7-0.2-0.1-1.2-1.20.2-0.40.30.91.3-1.41.2
Pavlov. Cond. latency score0.91.23.01.01.2-0.5-1.4-0.8-0.2-0.1-1.5-1.50.2-0.60.21.11.6-1.71.5
Pavlov. Cond. lever contacts1.82.44.81.92.20.4-2.1-1.71.21.1-2.0-1.91.40.8-0.71.71.8-1.31.2
Pavlov. Cond. magazine entry number0.81.02.50.4-0.01.00.3-0.21.51.20.50.60.81.6-1.1-0.3-0.91.6-1.5
Pavlov. Cond. intertrial magazine entries0.60.92.70.80.41.6-0.3-0.91.41.6-0.2-0.41.21.6-0.70.3-0.20.7-0.4
Pavlov. Cond. lever-magazine prob. diff.0.50.71.80.70.9-0.2-1.0-0.6-0.2-0.0-1.1-1.20.2-0.40.20.81.2-1.31.1
Pavlov. Cond. response bias0.40.61.20.50.90.2-0.9-0.70.00.2-1.0-1.00.5-0.00.41.01.1-1.11.1
Time in closed arm before self-admin1.11.43.31.11.40.7-1.4-1.30.60.9-1.6-1.80.80.40.11.21.5-1.41.2
Time in closed arm after self-admin0.20.20.4-0.5-0.70.00.60.7-0.3-0.10.70.5-0.4-0.0-0.1-0.7-0.70.6-0.3
Time in open arm before self-admin0.80.95.11.71.0-0.1-1.1-0.71.20.9-0.5-0.50.50.7-2.30.10.20.2-0.7
Time in open arm after self-admin1.71.95.60.61.3-1.2-1.4-0.9-0.8-0.9-1.6-1.5-0.1-1.30.71.32.0-2.42.0
Bone: periosteal estimation2.04.18.82.82.70.1-3.0-2.21.11.2-2.7-2.71.40.5-1.01.92.5-2.11.6
Bone: periosteal perimeter1.11.93.91.61.7-0.4-2.0-1.30.20.2-1.8-1.80.6-0.3-0.21.31.9-1.91.6
Bone: post-yield work2.43.56.51.52.41.0-2.3-2.31.11.3-2.5-2.51.80.9-0.12.32.4-1.91.3
Progressive ratio test 1 active lever presses0.30.42.00.90.1-0.9-0.60.40.00.30.0-0.3-0.8-0.3-1.4-0.9-0.2-0.0-0.5
Progressive ratio test 1 breakpoint0.40.42.31.10.2-0.9-0.70.30.10.3-0.1-0.4-0.8-0.3-1.5-0.9-0.2-0.1-0.5
Progressive ratio test 1 inactive lever presses0.30.41.00.2-0.4-0.8-0.10.9-0.4-0.20.50.3-0.9-0.5-0.8-1.0-0.60.3-1.0
Progressive ratio test 2 active lever presses0.20.31.01.00.3-0.2-0.5-0.10.60.7-0.3-0.6-0.30.2-1.0-0.5-0.0-0.1-0.4
Progressive ratio test 2 breakpoint0.20.20.70.80.2-0.2-0.4-0.00.50.7-0.2-0.5-0.30.1-0.8-0.5-0.1-0.0-0.4
Progressive ratio test 2 inactive lever presses0.20.31.00.1-0.5-0.80.00.7-0.5-0.30.40.1-1.0-0.6-0.5-0.9-0.40.0-0.8
Incentive Sensitization - Responses0.10.20.50.70.20.1-0.2-0.10.60.6-0.1-0.4-0.10.3-0.7-0.4-0.10.1-0.7
Incentive Sensitization - Breakpoint0.10.20.70.4-0.10.30.10.10.60.70.1-0.1-0.00.5-0.6-0.5-0.40.4-0.9
Sum of active levers in priming session hrs 5-60.80.81.50.91.2-0.2-1.0-1.10.4-0.0-1.2-0.90.6-0.10.11.21.2-1.11.2
Progressive ratio0.60.92.41.10.71.2-0.7-0.91.51.6-0.6-0.80.91.3-1.20.20.10.3-1.0
Food seeking constrained by brief footshock3.23.97.62.22.81.0-2.3-2.42.11.6-2.3-1.82.41.6-1.12.42.0-1.01.1
Seeking ratio, punishment vs. effort0.60.93.40.21.0-0.1-0.7-0.8-0.1-0.4-1.0-0.50.9-0.20.71.51.3-1.11.8
Retroperitoneal fat weight1.77.115.8-2.9-3.40.94.02.5-0.1-0.23.63.5-1.10.70.7-2.8-3.83.8-2.7
Reaction time number correct0.40.83.8-0.30.50.5-0.4-0.8-0.2-0.1-0.9-0.80.6-0.11.41.21.1-1.11.9
Reaction time mean minus median0.51.12.0-0.9-1.4-0.81.41.2-0.6-0.81.41.3-1.2-0.70.3-1.4-1.31.0-0.6
Reaction time mean minus median AUC0.30.81.5-0.8-1.1-1.01.01.0-0.8-0.91.00.9-1.2-0.90.6-1.0-0.80.4-0.1
Reaction time num false alarms0.60.92.4-1.5-1.2-0.51.11.0-1.2-1.20.91.0-0.8-0.91.1-0.5-0.60.2-0.4
Reaction time num false alarms AUC0.71.12.9-1.7-1.2-0.61.11.1-1.4-1.40.91.0-0.9-1.11.4-0.5-0.50.1-0.1
Reaction time trials correct on left0.40.83.8-0.30.50.5-0.4-0.8-0.2-0.1-0.9-0.80.6-0.11.41.21.1-1.11.9
Reaction time trials on left0.40.84.0-0.50.40.5-0.3-0.7-0.3-0.2-0.9-0.70.5-0.21.51.11.1-1.12.0
Reaction time mean0.71.12.7-0.6-1.2-1.40.91.3-1.0-1.01.10.9-1.7-1.20.2-1.5-1.00.4-0.4
Reaction time mean AUC0.40.71.8-0.5-0.9-1.20.71.0-0.9-0.80.80.6-1.4-1.10.3-1.1-0.70.2-0.0
Median of all reaction times0.81.12.9-0.5-1.1-1.50.71.3-1.1-1.01.00.7-1.7-1.30.1-1.5-0.90.2-0.3
Reaction time omissions2.03.07.1-2.7-2.2-0.82.12.1-2.1-1.81.71.7-1.6-1.62.0-1.2-1.30.60.3
Reaction time false alarm rate1.01.42.3-1.5-1.5-0.81.31.5-1.2-1.21.41.5-1.1-0.90.4-1.1-1.20.8-1.3
Reaction time premature initiation rate0.20.31.00.20.10.60.1-0.00.90.80.20.40.61.0-0.50.0-0.51.0-0.4
Reaction time premature initiations0.10.30.70.10.30.8-0.1-0.40.80.7-0.20.10.80.90.20.50.00.40.5
Std. dev. reaction times0.91.62.7-1.2-1.6-1.21.41.6-1.2-1.21.41.3-1.6-1.20.8-1.5-1.30.6-0.3
Reaction time trials completed0.40.84.0-0.50.40.5-0.3-0.7-0.3-0.2-0.9-0.70.5-0.21.51.11.1-1.12.0
Reaction time trials AUC0.50.94.3-0.40.60.5-0.4-0.8-0.3-0.1-1.0-0.80.6-0.21.51.31.2-1.22.1
Run reversals in cocaine runway, females1.21.22.2-0.9-1.0-1.40.81.5-1.1-1.11.21.3-1.2-1.0-0.3-1.1-1.00.7-1.2
Run reversals in cocaine runway, males1.21.22.90.31.01.7-0.6-1.31.11.0-1.0-0.91.71.30.51.50.9-0.41.2
Latency to leave start box in cocaine runway0.40.51.5-0.00.40.1-0.4-0.5-0.5-0.3-0.8-0.90.1-0.50.90.71.0-1.21.0
Latency to leave start box in cocaine runway, F0.10.10.10.00.20.3-0.2-0.20.00.2-0.3-0.30.20.20.30.30.3-0.20.3
Latency to leave start box in cocaine runway, M0.60.62.0-0.30.2-0.4-0.2-0.4-0.9-0.9-0.6-0.7-0.2-1.01.10.61.0-1.40.9
Std. dev. time between licks in bursts0.91.22.50.40.81.6-0.7-1.50.61.1-1.2-1.51.00.70.91.01.1-1.01.4
Total sessions with >9 infusions0.20.21.10.80.4-0.1-0.7-0.20.20.5-0.4-0.8-0.20.0-1.0-0.20.2-0.4-0.1
Short access day 1 total inactive lever presses0.60.73.30.6-0.3-0.7-0.20.80.30.30.70.5-0.70.1-1.8-1.2-1.00.9-1.5
Short access day 10 total inactive lever presses0.10.20.7-0.1-0.30.30.30.20.40.30.40.40.00.4-0.2-0.4-0.60.7-0.8
Short access day 1 total infusions0.10.10.40.50.1-0.1-0.3-0.20.10.2-0.3-0.6-0.3-0.1-0.3-0.30.1-0.4-0.1
Short access day 10 total infusions0.81.03.20.2-0.3-1.7-0.50.8-1.5-1.1-0.1-0.6-1.6-1.80.0-0.80.3-1.20.4
Short access total infusions0.40.51.9-0.1-0.6-1.00.10.7-0.9-0.50.3-0.2-1.4-1.10.1-1.0-0.2-0.5-0.1
Short access day 1 locomotion0.60.82.11.20.70.9-0.5-0.91.41.4-0.4-0.60.81.2-1.30.20.00.4-0.1
Short access day 10 total locomotion0.20.41.30.90.6-0.5-0.8-0.5-0.4-0.4-0.7-0.8-0.0-0.6-0.60.40.9-1.10.6
Short access total locomotion0.30.32.21.00.2-0.7-0.60.1-0.2-0.0-0.1-0.5-0.6-0.4-1.5-0.60.0-0.4-0.3
One hour access (0.3 mA shock)0.10.10.40.4-0.1-0.50.00.3-0.10.00.1-0.1-0.7-0.3-0.4-0.6-0.2-0.0-0.3
Compulsive drug intake0.81.04.90.40.4-2.2-0.70.4-1.3-1.4-0.3-0.1-1.0-1.7-0.30.00.7-1.10.5
One hour access (shock baseline)0.10.10.60.2-0.10.80.1-0.30.40.6-0.2-0.7-0.10.30.2-0.2-0.0-0.20.1
Social response proportion1.21.34.0-0.2-0.8-2.00.41.9-1.2-1.21.01.0-1.6-1.4-0.5-1.4-0.90.4-0.4
Social responses0.10.10.30.2-0.1-0.1-0.10.40.10.40.1-0.2-0.4-0.0-0.5-0.6-0.30.2-0.1
Social time0.10.10.6-0.30.0-0.7-0.20.5-0.5-0.4-0.1-0.0-0.5-0.70.2-0.10.2-0.30.3
Soleus weight5.917.429.14.05.04.0-4.4-5.44.54.5-4.6-4.35.34.2-1.64.73.8-1.82.2
Bone: stiffness0.10.20.6-0.10.40.2-0.2-0.5-0.1-0.2-0.5-0.30.4-0.10.50.80.7-0.60.7
Tibialis anterior weight3.110.417.83.24.22.3-3.6-4.22.82.6-3.9-3.43.92.5-0.64.13.6-2.22.1
Time to tail flick, vehicle, before self-admin0.10.10.6-0.4-0.2-0.00.50.1-0.2-0.20.10.2-0.1-0.20.80.1-0.10.00.3
Time to tail flick, vehicle, after self-admin1.01.33.61.11.3-0.4-1.5-1.2-0.2-0.2-1.5-1.60.4-0.5-0.31.11.7-1.91.1
Time to tail flick, test, before self-admin0.70.71.7-0.3-0.61.20.7-0.00.80.80.70.60.41.1-0.3-0.5-1.01.3-1.3
Time to tail flick, test, after self-admin1.01.02.71.20.91.0-0.8-0.91.61.6-0.5-0.51.01.5-1.50.2-0.00.6-0.6
Delta time to tail flick, vehicle, before/after SA1.51.42.90.91.40.6-1.4-1.50.20.3-1.6-1.61.00.10.11.51.7-1.61.3
Delta time to tail flick, test, before/after SA0.80.82.11.41.3-1.1-1.5-0.40.20.1-1.1-1.00.0-0.3-1.20.51.0-1.00.6
Tibia length0.92.410.93.31.6-0.9-2.3-0.61.41.4-1.0-1.4-0.10.5-3.1-0.50.4-0.2-1.4
Ambulatory time before self-admin0.81.32.20.21.11.0-1.0-1.30.20.5-1.4-1.51.00.31.01.51.5-1.41.5
Ambulatory time after self-admin1.92.34.32.12.1-0.1-2.1-1.61.00.9-2.0-2.00.90.3-0.91.31.8-1.61.4
Bone: tissue strength0.60.61.3-0.8-0.7-1.10.61.1-0.8-1.00.70.9-0.9-0.90.1-0.7-0.50.3-0.5
Total heroin consumption1.21.42.61.51.40.9-1.2-1.61.61.2-1.2-1.01.31.2-0.81.10.9-0.30.7
Bone: trabecular number0.40.62.6-0.8-0.11.00.2-0.3-0.50.1-0.5-0.80.2-0.11.60.50.6-0.91.5
Bone: trabecular spacing1.62.24.2-1.2-1.8-0.41.91.6-0.4-0.62.02.1-1.1-0.2-0.0-1.7-2.01.9-1.8
Bone: trabecular thickness0.20.20.80.40.0-0.9-0.20.5-0.0-0.10.20.3-0.5-0.3-0.9-0.5-0.30.2-0.5
Bone: trabecular tissue density0.50.72.00.6-0.3-1.30.10.90.1-0.40.80.9-0.8-0.3-1.4-1.0-0.90.8-1.4
Water consumed over 24 hours1.52.04.92.22.00.2-2.2-1.51.31.3-1.6-1.61.10.9-1.71.11.3-0.80.2
Number of responses in last shaping day2.52.85.52.31.91.2-1.8-1.82.22.2-1.6-1.91.31.7-2.20.70.9-0.4-0.1