Hub : Genes

Sbf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sbf1	0.06	0.03	9.2e-07	0.02	0.04	0.02	0.03	1.8e-03	7.9e-05	9.1e-04	9.6e-05
2	NAcc	gene expression	Sbf1	0.03	0.02	8.9e-04	0	0.02	0.01	0.01	6.1e-02	1.5e-03	9.0e-03	1.7e-02
3	Brain	mRNA stability	Sbf1	0.03	0.02	6.3e-04	0.02	0.03	0.02	0.03	3.6e-03	5.3e-04	4.3e-03	1.5e-03
4	pVTA	mRNA stability	Sbf1	0.06	0.04	6.7e-04	0.05	0.03	0.03	0.03	7.3e-05	1.1e-03	3.1e-03	9.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.9	1.5	3.3	-1.4	0.8	1.8	0.0
Area under the delay curve	0.4	0.5	1.1	-0.5	0.2	0.7	-1.0
BMI with tail	4.0	13.7	18.6	4.3	-4.1	-3.8	-2.3
BMI without tail	1.5	4.7	7.6	2.5	-2.1	-2.8	-0.5
Body weight	1.7	7.4	10.4	3.2	-2.9	-3.0	-1.3
Weight adjusted by age	3.3	5.0	6.1	2.5	-2.4	-1.9	-2.1
Bone surface	0.7	1.2	3.1	-0.9	0.2	1.8	-0.9
Bone volume	0.9	1.5	4.0	-1.3	0.6	2.0	-0.4
Breakpoint value in progressive ratio session	0.4	0.5	0.7	0.7	-0.8	-0.3	-0.8
Number of licking bursts	0.0	0.0	0.1	-0.3	0.3	0.1	0.2
Context. condit. distance diff. score	1.1	1.4	3.0	1.3	-0.9	-1.7	-0.1
Locomotion velocity, session 1	0.2	0.2	0.2	0.4	-0.4	-0.4	-0.5
Locomotion distance, session 1	1.4	1.8	2.7	-1.6	1.5	1.5	0.1
Locomotion velocity, session 2	0.7	0.8	1.2	1.0	-1.1	-0.7	-0.9
Locomotion distance, session 2	0.6	0.8	1.2	-1.1	1.0	1.0	0.1
Locomotion velocity, session 3	0.7	0.8	2.3	-0.2	0.6	-0.6	1.5
Locomotion distance, session 3	0.3	0.3	0.4	-0.6	0.6	0.4	0.6
Stereotopy head waving bouts, day 3	1.5	1.7	4.0	-1.5	0.9	2.0	-0.2
Stereotopy head waving duration, day 3	0.7	0.9	1.4	-1.1	0.8	1.2	0.4
Locomotion velocity, session 7	0.3	0.3	0.9	0.4	-0.2	-0.5	0.9
Locomotion distance, session 7	0.2	0.2	0.5	0.4	-0.1	-0.7	0.4
Stereotopy head waving bouts, day 7	0.6	0.7	1.4	-1.0	0.7	1.2	0.1
Stereotopy head waving duration, day 7	1.2	1.4	1.9	-1.4	1.1	1.3	0.9
Locomotion velocity, session 8	0.4	0.5	1.0	0.9	-1.0	-0.7	-0.0
Locomotion distance, session 8	0.7	1.0	1.2	1.1	-0.9	-1.1	-1.0
Degree of sensitization distance	2.1	2.2	2.7	1.6	-1.6	-1.3	-1.3
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.4	0.5	0.2	0.6
Conditioned locomotion	0.2	0.3	0.5	0.6	-0.5	-0.7	-0.1
Cocaine response after cond. corrected	0.9	1.1	1.6	1.3	-1.2	-1.1	-0.6
Cocaine response after cond. not corrected	2.1	2.4	3.4	1.8	-1.6	-1.8	-0.6
Cocaine response before conditioning	0.7	0.9	1.2	1.1	-0.9	-1.1	-0.4
Saline control response	1.7	2.2	3.9	1.4	-1.6	-0.7	-2.0
Bone: connectivity density	0.7	1.2	2.5	-1.2	0.8	1.6	0.0
Bone: cortical apparent density	2.3	3.2	4.3	-2.1	2.0	1.7	1.2
Bone: cortical area	1.0	1.5	2.4	1.2	-1.6	-0.3	-1.4
Bone: cortical porosity	1.5	1.6	3.7	1.0	-1.3	-0.3	-1.9
Bone: cortical porosity	2.8	3.0	5.4	1.6	-1.8	-0.9	-2.3
Bone: cortical thickness	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1
Bone: cortical thickness	0.3	0.3	0.8	0.3	-0.0	-0.7	0.9
Bone: cortical tissue density	2.1	2.8	3.8	-2.0	1.9	1.6	1.1
Condit. Reinf. active minus inactive responses	1.7	1.9	3.1	1.3	-1.8	-0.4	-1.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.5	0.2	-0.6
Condit. Reinf. active responses	2.4	3.0	4.6	1.8	-2.1	-1.0	-1.8
Condit. Reinf. inactive responses	1.7	2.1	2.8	1.6	-1.7	-1.2	-1.3
Incentive salience index mean	3.0	3.7	5.6	1.9	-2.4	-0.8	-2.3
Condit. Reinf. lever presses	2.6	3.6	5.0	1.9	-2.2	-1.0	-2.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	0.1	-0.6	0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	-0.1	-0.2	0.7	-0.2
Condit. Reinf. active responses	1.0	1.5	3.2	0.9	-1.4	0.2	-1.8
Condit. Reinf. inactive responses	1.0	1.3	2.0	1.1	-1.1	-0.8	-1.4
Condit. Reinf. lever presses	1.6	2.3	3.6	1.6	-1.9	-0.7	-1.6
Condit. Reinf. lever reinforcers received	1.0	1.4	3.2	0.8	-1.3	0.4	-1.8
Conditioned reinforcement - actives	0.8	1.4	2.0	1.2	-1.4	-0.6	-1.4
Conditioned reinforcement - inactives	0.1	0.2	0.3	0.5	-0.4	-0.6	0.0
Conditioned locomotion	2.3	3.0	4.2	2.1	-1.8	-1.9	-0.9
Patch foraging indifference point 0 sec	0.4	0.7	0.9	0.9	-1.0	-0.7	-0.6
Patch foraging indifference point AUC	0.8	1.2	3.5	-0.0	-0.6	1.0	-1.9
Delay disc. indifference point, 0s delay	2.6	2.8	5.5	1.4	-1.9	-0.2	-2.3
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	-0.1	-0.2	0.4	-1.1
Delay disc. indifference point, 2s delay	2.2	2.4	5.2	-0.8	0.0	2.0	-2.3
Delay disc. indifference point, 24s delay	0.2	0.3	0.4	0.6	-0.4	-0.7	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	-0.4	0.2	0.6	-0.9
Delay disc. indifference point, 8s delay	0.6	0.7	1.1	-1.0	1.1	0.7	0.2
Indifference point function ln k	1.3	2.3	4.4	1.8	-1.3	-2.1	0.0
Indifference point function log k	1.3	2.3	4.4	1.8	-1.3	-2.1	0.0
Patch foraging total patch changes 0 sec	0.1	0.3	0.4	0.6	-0.6	-0.4	-0.4
Patch foraging total patch changes 12 sec	0.8	1.1	2.5	0.5	-1.1	0.5	-1.6
Patch foraging total patch changes 18 sec	0.8	1.3	2.9	-1.0	0.4	1.7	-1.0
Patch foraging total patch changes 24 sec	0.3	0.6	1.6	-0.4	-0.2	1.3	-0.7
Patch foraging total patch changes 6 sec	0.5	0.8	2.5	0.4	-0.7	0.2	-1.6
Patch foraging time to switch 0 sec	0.3	0.5	0.7	-0.9	0.8	0.8	0.4
Patch foraging water rate 0 sec	0.5	1.1	2.4	1.2	-0.8	-1.5	0.3
Patch foraging water rate 12 sec	1.4	2.8	4.3	2.0	-1.6	-2.1	-0.5
Patch foraging water rate 18 sec	2.3	3.6	7.1	2.2	-1.5	-2.7	0.4
Patch foraging water rate 24 sec	0.9	1.3	3.3	1.1	-0.5	-1.8	0.5
Patch foraging water rate 6 sec	0.6	0.9	2.1	1.0	-0.6	-1.4	-0.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.9	-0.9	0.8	0.9	0.6
Distance traveled before self-admin	0.9	1.2	1.7	-1.3	1.2	1.1	0.5
Distance traveled after self-admin	0.2	0.2	0.4	-0.4	0.5	0.2	0.6
Extensor digitorum longus weight	0.3	1.0	1.9	1.2	-0.9	-1.4	-0.0
Bone: elastic displacement	0.2	0.2	0.3	-0.5	0.5	0.4	-0.2
Bone: elastic work	0.4	0.5	0.6	0.7	-0.7	-0.7	-0.7
Bone: endosteal estimation	0.5	1.1	1.7	1.1	-1.3	-0.5	-1.2
Bone: endosteal perimeter	2.5	5.4	10.6	1.8	-2.8	0.1	-3.2
Epididymis fat weight	2.1	7.1	12.2	2.9	-3.5	-1.4	-2.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.1	-0.0	-0.1	-0.6
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.0	-0.1	0.1	0.2
Diff in mean of infusions in LGA sessions	2.4	2.9	4.4	1.7	-2.0	-0.7	-2.1
Delay discount exponential model param	0.3	0.3	0.6	0.5	-0.4	-0.6	0.8
Extinction: sum of active levers before priming	0.3	0.3	1.0	0.0	-0.2	0.5	-1.0
Active lever presses in extinction session 6	2.1	2.1	3.0	1.7	-1.5	-1.6	-0.7
Bone: final force	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.3
Bone: final moment	0.0	0.1	0.1	-0.3	0.1	0.4	-0.1
Food consumed during 24 hour testing period	1.7	2.3	3.2	1.8	-1.6	-1.8	-0.8
Glucose	0.1	0.1	0.4	-0.0	-0.1	0.4	-0.7
Heart weight	0.2	0.3	0.7	0.4	-0.1	-0.7	0.8
Delay discount hyperbolic model param	0.5	0.6	0.8	0.7	-0.5	-0.9	0.8
Intermittent access intake day 1-15 change	0.7	1.4	1.9	1.4	-1.3	-1.0	-0.9
Intermittent access intake escalation	0.7	1.5	2.1	1.4	-1.4	-1.0	-1.0
Intermittent access intake escalation 2	3.4	3.9	5.8	2.1	-2.4	-1.0	-2.1
Intermitt. access day 1 inactive lever presses	0.4	1.3	1.8	1.3	-1.3	-0.9	-1.1
Intermitt. access day 15 inactive lever presses	1.2	2.5	4.9	1.8	-1.3	-2.2	0.2
Intermitt. access escalation Index	0.5	0.7	0.9	-0.8	0.9	0.7	1.0
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.1	0.3	-0.2	0.4
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.6	-0.4	-0.6	-0.2
Intermittent access terminal intake (last 3 days)	1.6	2.1	2.8	1.7	-1.6	-1.2	-1.3
Intermittent access total infusions	0.2	0.2	0.3	0.6	-0.5	-0.5	-0.5
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.0	-0.0	0.1	-0.2
Intermittent access day 15 total locomotion	0.8	1.5	1.8	1.4	-1.3	-1.1	-1.2
Intermittent access total locomotion	0.7	0.8	1.2	1.0	-0.8	-1.1	-0.6
Intermittent access standard deviation	0.2	0.4	0.8	0.6	-0.3	-0.9	0.5
Left kidney weight	4.8	22.4	30.5	5.5	-5.2	-4.7	-3.0
Right kidney weight	6.9	31.6	43.6	6.6	-6.0	-6.1	-3.1
Cocaine induced anxiety	0.6	0.9	1.6	1.2	-0.9	-1.2	0.0
Post-drug Anxiety	1.0	1.0	2.1	1.2	-0.8	-1.4	0.2
Baseline Anxiety	0.4	0.5	0.7	-0.8	0.8	0.6	0.5
Tail length	0.3	1.4	1.7	-1.3	1.2	1.3	0.8
Length with tail	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1
Length without tail	0.6	2.0	3.0	1.5	-1.7	-0.8	-1.5
Times rat made contact with spout	1.3	1.5	3.2	0.6	0.3	-1.8	1.5
Lifetime Intake	0.2	0.2	0.4	0.6	-0.4	-0.7	-0.3
Liver weight, left	0.6	1.0	1.6	1.0	-1.0	-0.6	-1.3
Liver weight, right	0.1	0.1	0.4	0.0	-0.0	0.1	-0.6
Locomotor activity	0.9	1.4	2.5	1.1	-1.5	-0.2	-1.6
Locomotor testing distance	0.4	0.7	0.9	-1.0	0.9	0.9	0.4
Locomotor testing rearing	0.7	1.4	3.9	0.2	-0.9	0.9	-2.0
Locomotion in novel chamber	1.1	1.4	2.9	0.8	-0.2	-1.7	1.5
Locomotion in novel chamber post-restriction	0.4	0.6	1.9	-0.1	-0.3	0.7	-1.4
Fecal boli incidents, locomotor time 1	0.4	0.6	0.9	-0.9	1.0	0.6	0.6
Change in fecal boli incidents, locomotor task	0.6	0.6	0.8	0.9	-0.8	-0.7	-0.4
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	1.0	-1.2	-0.4	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.1	0.2	-0.0	0.3
Rest time, locomotor task time 1	0.6	0.7	1.2	-0.7	1.1	-0.1	1.1
Distance moved, locomotor task time 1	0.4	0.7	1.3	0.9	-1.2	-0.1	-0.8
Vertical activity count, locomotor time 1	0.8	2.0	3.6	1.5	-1.9	-0.6	-1.3
Time >=10cm from walls, locomotor time 2	2.0	3.0	4.2	1.9	-2.0	-1.3	-1.5
Bouts of movement, locomotor time 2	0.2	0.4	0.5	-0.7	0.7	0.5	0.6
Total resting periods, locomotor time 2	0.2	0.4	0.5	-0.7	0.7	0.6	0.4
Rest time, locomotor task time 2	1.5	1.9	2.7	-1.4	1.6	0.7	1.6
Distance moved, locomotor task time 2	2.6	3.1	4.3	1.9	-2.1	-1.1	-1.8
Vertical activity count, locomotor time 2	2.5	3.5	4.9	2.0	-2.2	-1.2	-1.9
Light reinforcement 1	0.7	1.8	2.8	1.3	-1.6	-0.5	-1.7
Light reinforcement 2	4.0	6.1	8.6	2.7	-2.9	-1.6	-2.5
Bone: marrow area	0.4	0.9	1.3	0.9	-1.1	-0.3	-1.1
Bone: maximum diameter	1.5	2.9	4.9	1.9	-2.2	-0.9	-1.6
Bone: maximum force	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.3
Bone: maximum moment	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1
Mean time between licks in bursts	1.9	4.7	6.5	-2.4	2.6	1.6	1.9
Mean num. licks in bursts	0.2	0.4	0.8	0.3	0.1	-0.9	0.8
Cd content in liver	0.2	0.3	0.5	-0.6	0.4	0.7	-0.2
Co content in liver	0.9	1.0	2.2	0.8	-1.1	-0.2	-1.5
Cu content in liver	2.7	3.2	6.9	-1.4	1.9	0.2	2.6
Fe content in liver	0.1	0.2	0.4	-0.1	-0.1	0.4	-0.6
K content in liver	0.2	0.2	0.6	-0.4	0.1	0.8	0.3
Mg content in liver	0.6	0.6	1.5	-0.8	0.3	1.2	-0.4
Mn content in liver	0.1	0.2	0.3	0.0	-0.5	0.6	-0.3
Na content in liver	3.0	3.3	7.6	-2.0	1.2	2.8	-0.0
Rb content in liver	0.3	0.3	0.9	0.3	-0.5	0.3	-1.0
Se content in liver	0.1	0.2	0.3	0.4	-0.4	-0.5	0.2
Sr content in liver	2.4	2.0	2.7	-1.5	1.6	1.0	1.5
Zn content in liver	1.3	1.5	2.3	-1.2	1.5	0.3	1.5
Bone: minimum diameter	0.6	1.2	1.9	1.0	-1.4	-0.2	-1.3
Time in familiar zone, hab. session 1	0.5	0.5	0.9	0.2	0.3	-0.9	1.0
Time in novel zone, hab. session 1	0.7	0.7	1.5	-0.6	0.1	1.2	-0.8
Total zone transitions, hab. session 1	1.4	2.0	3.0	-1.7	1.7	1.5	0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.1	-0.0	-0.1	-0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.8	-0.0	-0.0	0.1	-0.9
Time in familiar zone, hab. session 2	0.8	0.8	1.6	1.0	-0.6	-1.2	0.6
Time in novel zone, hab. session 2	1.3	1.3	2.2	-1.4	1.0	1.5	-0.1
Total zone transitions, hab. session 2	0.1	0.2	0.6	0.2	0.1	-0.8	0.2
Total locomotion distance, hab. session 2	1.1	1.5	2.4	1.3	-1.0	-1.5	-0.9
Locomotion velocity, hab. session 2	1.1	1.5	2.3	1.3	-1.0	-1.5	-1.0
Novel to familiar place preference ratio	0.8	0.9	1.6	-0.9	0.9	0.6	1.3
Novelty place preference	0.6	0.7	1.5	-0.7	0.8	0.4	1.2
Time in novel zone, NPP test	0.9	1.0	2.1	-0.9	1.0	0.4	1.5
Total zone transitions, NPP test	0.5	0.7	1.3	-0.9	1.1	0.5	0.6
Total locomotion distance, NPP test	0.2	0.3	0.8	0.3	-0.3	-0.2	-0.9
Locomotion velocity, NPP test	0.2	0.3	0.9	0.4	-0.4	-0.4	-0.9
Intraocular pressure	0.4	0.6	1.6	0.2	-0.6	0.5	-1.3
Delta distance traveled before/after self-admin	1.7	1.8	3.3	1.6	-1.2	-1.8	0.1
Delta ambulatory time before/after self-admin	0.8	1.0	2.1	1.1	-0.8	-1.5	0.1
Parametrial fat weight	0.3	0.7	1.0	1.0	-0.9	-0.9	-0.4
Pavlov. Cond. lever latency	1.9	2.5	3.2	-1.6	1.8	1.0	1.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	-0.5	0.1	0.9	-0.2
Pavlov. Cond. change in total contacts	0.5	0.5	1.1	0.0	-0.6	0.7	-1.1
Pavlov. Cond. index score	0.2	0.2	0.5	0.2	-0.5	0.3	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.8	0.5	-0.8	0.1	-0.9
Pavlov. Cond. lever contacts	1.6	1.9	2.9	1.3	-1.6	-0.7	-1.7
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	0.5	-0.2	-1.0	0.4
Pavlov. Cond. intertrial magazine entries	1.6	2.0	2.7	1.5	-1.6	-1.0	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.0	-0.3	0.5	-0.7
Pavlov. Cond. response bias	0.4	0.5	1.0	0.5	-0.7	0.0	-1.0
Pavlov. Cond. lever latency	1.1	1.5	2.3	-1.5	1.4	1.2	0.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	1.0	-1.0	-0.7	-0.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	0.6	-0.9	0.1	-0.7
Pavlov. Cond. index score	0.8	1.1	1.7	1.3	-1.3	-0.9	-0.3
Pavlov. Cond. latency score	1.3	1.7	2.6	1.6	-1.5	-1.3	-0.4
Pavlov. Cond. lever contacts	1.2	1.6	2.5	1.6	-1.5	-1.3	-0.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.6	-1.3	1.2	1.0	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.1	0.4	-0.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.8	1.4	-1.3	-1.0	-0.3
Pavlov. Cond. response bias	0.4	0.5	0.9	0.9	-1.0	-0.5	-0.1
Time in closed arm before self-admin	1.1	1.4	3.8	-0.7	-0.2	2.0	-1.1
Time in closed arm after self-admin	1.3	1.3	3.7	0.3	-0.9	0.9	-1.9
Time in open arm before self-admin	0.3	0.3	0.5	-0.3	0.7	-0.4	0.6
Time in open arm after self-admin	0.0	0.0	0.1	0.1	0.0	-0.3	0.2
Bone: periosteal estimation	0.9	1.9	3.1	1.4	-1.7	-0.4	-1.6
Bone: periosteal perimeter	2.4	4.1	6.6	1.9	-2.6	-0.4	-2.5
Bone: post-yield work	1.1	1.6	2.5	-1.3	1.6	0.6	1.4
Progressive ratio test 1 active lever presses	0.4	0.5	1.3	-0.3	0.7	-0.3	1.1
Progressive ratio test 1 breakpoint	0.4	0.5	1.3	-0.4	0.7	-0.2	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	0.5	-0.5	-0.3	-0.3
Progressive ratio test 2 active lever presses	0.8	0.9	1.2	1.1	-0.9	-1.1	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	0.9	0.9	-0.8	-0.9	-0.6
Progressive ratio test 2 inactive lever presses	0.9	1.5	1.8	1.3	-1.3	-1.1	-1.1
Incentive Sensitization - Responses	1.7	2.4	3.2	1.6	-1.7	-1.0	-1.8
Incentive Sensitization - Breakpoint	1.7	2.2	3.0	1.5	-1.6	-1.0	-1.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.2	-0.4	0.1	-0.6
Progressive ratio	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.3
Food seeking constrained by brief footshock	3.2	3.9	5.2	2.2	-1.8	-2.3	-1.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.5	-0.6	-0.2	-0.8
Retroperitoneal fat weight	2.5	10.8	13.8	3.7	-3.7	-2.8	-2.8
Reaction time number correct	0.3	0.6	1.0	-0.9	1.0	0.6	-0.0
Reaction time mean minus median	0.0	0.1	0.3	0.3	-0.5	-0.0	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.2	0.4	-0.5	-0.3	-0.1
Reaction time num false alarms	0.1	0.2	0.5	-0.4	0.1	0.7	-0.3
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Reaction time trials correct on left	0.3	0.6	1.0	-0.9	1.0	0.6	-0.0
Reaction time trials on left	0.3	0.6	1.1	-1.0	1.1	0.6	0.0
Reaction time mean	0.7	1.1	3.0	-0.8	1.0	0.2	1.7
Reaction time mean AUC	0.7	1.2	2.7	-0.9	1.0	0.3	1.6
Median of all reaction times	1.4	2.0	5.0	-1.0	1.4	0.2	2.2
Reaction time omissions	0.7	1.0	1.2	-1.0	1.1	0.6	1.1
Reaction time false alarm rate	0.0	0.0	0.1	0.1	-0.3	0.2	0.0
Reaction time premature initiation rate	4.9	6.8	9.9	2.6	-3.2	-1.1	-3.1
Reaction time premature initiations	1.8	3.3	6.1	1.6	-2.0	-0.6	-2.5
Std. dev. reaction times	0.1	0.2	0.5	0.1	-0.0	-0.3	0.7
Reaction time trials completed	0.3	0.6	1.1	-1.0	1.1	0.6	0.0
Reaction time trials AUC	0.2	0.4	0.8	-0.8	0.9	0.4	0.0
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.0	0.2	-0.3	0.7
Run reversals in cocaine runway, males	0.5	0.5	0.8	-0.7	0.6	0.9	-0.5
Latency to leave start box in cocaine runway	1.5	1.7	4.0	1.4	-0.8	-2.0	0.2
Latency to leave start box in cocaine runway, F	2.2	2.5	5.9	1.5	-0.8	-2.4	0.9
Latency to leave start box in cocaine runway, M	0.3	0.3	0.9	0.3	-0.4	-0.1	-0.9
Std. dev. time between licks in bursts	1.7	2.2	3.1	1.5	-1.5	-1.2	-1.7
Total sessions with >9 infusions	0.3	0.3	0.9	0.3	0.1	-0.9	0.6
Short access day 1 total inactive lever presses	2.8	3.7	6.8	2.2	-1.7	-2.6	-0.3
Short access day 10 total inactive lever presses	4.0	9.7	13.2	3.6	-3.6	-2.7	-2.4
Short access day 1 total infusions	0.7	0.9	2.5	0.9	-0.4	-1.6	0.4
Short access day 10 total infusions	0.6	0.8	1.5	1.0	-0.7	-1.2	-0.1
Short access total infusions	0.5	0.6	1.5	0.9	-0.5	-1.2	0.0
Short access day 1 locomotion	0.7	0.9	2.0	1.0	-0.6	-1.4	0.5
Short access day 10 total locomotion	0.5	0.9	1.7	1.1	-0.8	-1.3	-0.2
Short access total locomotion	0.4	0.5	1.0	0.8	-0.5	-1.0	0.1
One hour access (0.3 mA shock)	1.8	2.0	2.9	1.6	-1.7	-0.8	-1.5
Compulsive drug intake	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.0
One hour access (shock baseline)	0.8	1.2	1.6	1.2	-1.3	-0.8	-1.2
Social response proportion	0.2	0.2	0.6	-0.4	0.1	0.8	-0.3
Social responses	0.1	0.2	0.5	-0.1	-0.2	0.7	-0.4
Social time	0.3	0.4	1.2	0.4	0.1	-1.1	0.6
Soleus weight	0.8	2.4	4.3	1.8	-1.4	-2.1	-0.1
Bone: stiffness	0.1	0.2	0.3	-0.4	0.4	0.2	0.6
Tibialis anterior weight	0.0	0.0	0.1	0.2	-0.2	-0.3	0.1
Time to tail flick, vehicle, before self-admin	2.4	2.5	3.7	1.7	-1.9	-1.2	-1.3
Time to tail flick, vehicle, after self-admin	0.7	0.9	1.5	1.1	-1.2	-0.6	-0.8
Time to tail flick, test, before self-admin	0.4	0.4	1.0	0.7	-1.0	-0.2	-0.5
Time to tail flick, test, after self-admin	2.2	2.3	4.1	1.8	-1.4	-2.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.2	-1.0	1.1	0.8	0.7
Delta time to tail flick, test, before/after SA	0.3	0.4	1.1	0.4	0.1	-1.0	0.5
Tibia length	0.9	2.5	3.4	-1.8	1.9	1.5	1.1
Ambulatory time before self-admin	0.4	0.7	0.9	-0.8	1.0	0.4	0.9
Ambulatory time after self-admin	0.1	0.1	0.3	-0.0	0.2	-0.3	0.5
Bone: tissue strength	1.1	1.1	2.5	-1.1	1.6	0.1	0.8
Total heroin consumption	0.2	0.3	0.5	0.5	-0.6	-0.2	-0.7
Bone: trabecular number	0.7	1.1	2.5	-1.2	0.8	1.6	-0.0
Bone: trabecular spacing	1.9	2.5	4.4	1.8	-1.3	-2.1	-0.6
Bone: trabecular thickness	0.2	0.3	0.5	0.0	-0.4	0.7	-0.7
Bone: trabecular tissue density	1.5	2.2	2.8	-1.6	1.7	1.3	1.3
Water consumed over 24 hours	0.3	0.4	0.8	0.7	-0.4	-0.9	-0.3
Number of responses in last shaping day	0.4	0.5	0.8	-0.6	0.9	-0.1	0.9