Hub : Genes

Sars2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Sars2 0.13 0.08 1.8e-11 0.07 0.07 0.07 0.07 8.8e-08 4.7e-08 6.5e-08 8.4e-08
2 Liver gene expression Sars2 0.36 0.17 0.0e+00 0.2 0.19 0.2 0.2 1.4e-21 7.6e-21 8.1e-22 1.5e-21
3 PL gene expression Sars2 0.51 0.19 0.0e+00 0.43 0.19 0.44 0.23 1.4e-51 5.1e-20 3.7e-53 7.6e-25
4 BLA gene expression Sars2 0.57 0.18 0.0e+00 0.47 0.43 0.47 0.11 9.6e-28 2.0e-24 8.5e-28 1.2e-06
5 NAcc gene expression Sars2 0.39 0.15 0.0e+00 0.38 0.37 0.39 0.38 2.1e-61 7.5e-60 1.6e-62 7.9e-62
6 OFC gene expression Sars2 0.49 0.19 6.2e-09 0.29 0.3 0.25 0.32 1.1e-07 5.8e-08 1.2e-06 2.3e-08
7 IL gene expression Sars2 0.38 0.17 2.5e-07 0.27 0.18 0.21 0.22 3.0e-07 4.1e-05 1.0e-05 6.8e-06
8 pVTA gene expression Sars2 0.31 0.12 0.0e+00 0.27 0.04 0.28 0.02 9.8e-22 5.6e-04 2.5e-22 1.0e-02
9 IC gene expression Sars2 0.55 0.15 0.0e+00 0.38 0.03 0.36 0.09 6.2e-17 3.2e-02 1.1e-15 1.7e-04
10 Brain gene expression Sars2 0.5 0.19 0.0e+00 0.35 0.34 0.36 0.37 1.2e-33 5.0e-33 3.4e-35 6.3e-36
11 LHb gene expression Sars2 0.53 0.19 5.8e-08 0.28 0.27 0.3 0.26 2.2e-07 3.7e-07 8.4e-08 6.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.10.20.3-0.2-0.1-0.2-0.2-0.3-0.2-0.3-0.3-0.2-0.5
Area under the delay curve0.00.00.1-0.3-0.1-0.00.10.10.2-0.10.10.1-0.20.3
BMI with tail0.10.20.8-0.9-0.4-0.5-0.5-0.3-0.4-0.2-0.3-0.5-0.4-0.4
BMI without tail0.51.61.91.31.31.31.31.41.31.31.31.21.21.0
Body weight2.310.011.83.43.13.43.33.33.13.03.23.03.02.8
Weight adjusted by age0.00.00.1-0.20.1-0.00.10.10.10.20.10.10.10.1
Bone surface0.30.51.51.20.60.80.70.70.60.40.60.60.50.4
Bone volume0.30.61.61.30.70.90.80.80.60.60.70.70.70.5
Breakpoint value in progressive ratio session1.41.63.60.21.21.21.31.31.31.31.41.21.11.9
Number of licking bursts1.32.13.1-0.8-1.3-1.6-1.5-1.6-1.5-1.4-1.6-1.5-1.4-1.8
Context. condit. distance diff. score0.10.10.2-0.4-0.1-0.4-0.3-0.3-0.20.0-0.2-0.2-0.1-0.4
Locomotion velocity, session 12.42.63.5-1.9-1.6-1.8-1.6-1.7-1.6-1.4-1.6-1.6-1.5-1.3
Locomotion distance, session 10.70.91.11.01.01.01.01.01.01.01.01.01.00.9
Locomotion velocity, session 20.40.40.5-0.7-0.6-0.7-0.7-0.6-0.7-0.5-0.6-0.7-0.7-0.7
Locomotion distance, session 20.50.71.5-1.2-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.8-0.5
Locomotion velocity, session 30.10.20.50.6-0.2-0.2-0.2-0.4-0.3-0.3-0.5-0.3-0.3-0.7
Locomotion distance, session 36.97.58.32.92.92.82.72.82.72.92.72.72.82.3
Stereotopy head waving bouts, day 30.30.30.8-0.9-0.5-0.7-0.5-0.6-0.5-0.4-0.5-0.5-0.4-0.3
Stereotopy head waving duration, day 32.42.83.3-1.8-1.7-1.8-1.7-1.7-1.7-1.6-1.7-1.7-1.6-1.4
Locomotion velocity, session 70.00.00.30.50.10.20.00.10.00.1-0.00.0-0.0-0.3
Locomotion distance, session 70.10.20.60.80.40.50.30.40.30.40.30.30.3-0.1
Stereotopy head waving bouts, day 70.20.20.8-0.9-0.4-0.6-0.5-0.4-0.3-0.2-0.3-0.4-0.3-0.2
Stereotopy head waving duration, day 70.70.91.9-1.4-0.9-1.1-1.0-0.9-0.9-0.7-0.9-0.9-0.8-0.7
Locomotion velocity, session 82.73.23.8-1.5-1.7-1.9-1.9-1.9-1.8-1.6-1.9-1.8-1.7-1.9
Locomotion distance, session 80.40.51.5-1.2-0.6-0.9-0.8-0.7-0.6-0.4-0.6-0.7-0.5-0.5
Degree of sensitization distance3.94.04.4-1.8-2.1-1.9-2.0-2.0-2.0-2.1-2.0-2.0-2.1-2.0
Degree of sensitization stereotypy0.00.00.2-0.40.1-0.10.00.10.20.30.20.10.20.3
Conditioned locomotion1.11.32.21.51.30.91.01.01.11.40.91.11.30.5
Cocaine response after cond. corrected0.50.61.21.10.80.80.70.80.70.70.70.70.80.4
Cocaine response after cond. not corrected0.80.91.61.31.01.01.01.00.90.90.90.90.90.7
Cocaine response before conditioning1.61.92.51.11.41.41.51.31.41.51.41.41.21.6
Saline control response0.10.10.3-0.40.30.20.20.30.30.40.40.30.30.5
Bone: connectivity density0.40.61.0-0.4-0.8-0.7-0.8-0.7-0.8-0.8-0.8-0.8-0.7-1.0
Bone: cortical apparent density2.43.35.1-2.2-1.8-2.0-1.8-1.9-1.8-1.8-1.8-1.8-1.6-1.5
Bone: cortical area2.64.05.01.61.92.02.02.02.01.92.12.02.02.2
Bone: cortical porosity0.20.20.4-0.6-0.4-0.5-0.5-0.5-0.5-0.3-0.4-0.5-0.4-0.4
Bone: cortical porosity0.30.30.4-0.6-0.5-0.5-0.6-0.6-0.6-0.4-0.5-0.5-0.5-0.5
Bone: cortical thickness1.72.73.31.31.71.61.71.61.71.81.71.71.81.7
Bone: cortical thickness0.00.00.10.20.10.00.1-0.00.10.2-0.00.10.2-0.1
Bone: cortical tissue density2.83.85.4-2.3-2.0-2.1-2.0-2.0-1.9-1.9-1.9-1.9-1.7-1.7
Condit. Reinf. active minus inactive responses0.20.20.3-0.2-0.4-0.5-0.4-0.5-0.4-0.3-0.5-0.4-0.4-0.5
Condit. Reinf. active-inactive response ratio0.10.10.1-0.3-0.3-0.4-0.3-0.4-0.3-0.3-0.4-0.3-0.2-0.2
Condit. Reinf. active responses0.91.11.5-0.8-1.0-1.1-1.0-1.1-1.1-0.9-1.1-1.1-1.1-1.2
Condit. Reinf. inactive responses0.70.91.2-0.8-0.9-0.9-1.0-0.9-1.0-0.8-1.0-1.0-1.0-1.1
Incentive salience index mean0.00.00.20.40.0-0.0-0.0-0.1-0.10.0-0.2-0.1-0.1-0.4
Condit. Reinf. lever presses0.10.20.80.90.40.50.50.40.40.40.30.40.30.2
Condit. Reinf. active minus inactive responses4.15.36.11.92.42.22.32.32.42.52.32.42.52.2
Condit. Reinf. active-inactive response ratio3.03.44.41.11.91.61.81.82.02.02.01.92.12.0
Condit. Reinf. active responses4.86.67.62.22.72.42.62.62.62.82.62.62.72.5
Condit. Reinf. inactive responses1.11.51.81.01.21.21.31.21.21.31.21.21.11.3
Condit. Reinf. lever presses6.79.310.43.13.23.03.03.03.13.23.03.13.12.7
Condit. Reinf. lever reinforcers received5.98.29.32.73.02.82.92.82.93.02.82.93.02.7
Conditioned reinforcement - actives0.10.10.70.30.0-0.3-0.3-0.2-0.20.1-0.3-0.2-0.0-0.8
Conditioned reinforcement - inactives0.81.13.11.81.21.11.01.01.01.00.91.10.90.3
Conditioned locomotion1.31.72.9-1.1-1.2-1.4-1.5-1.3-1.2-1.0-1.3-1.3-1.2-1.7
Patch foraging indifference point 0 sec0.20.50.60.80.70.60.70.70.70.70.60.70.70.5
Patch foraging indifference point AUC0.81.12.1-1.5-1.3-0.8-0.9-0.9-1.1-1.2-0.8-1.2-1.2-0.2
Delay disc. indifference point, 0s delay0.10.20.8-0.40.10.30.30.40.40.10.50.30.20.9
Delay disc. indifference point, 16s delay1.11.21.71.11.11.01.11.11.31.01.01.11.00.9
Delay disc. indifference point, 2s delay0.10.10.2-0.4-0.3-0.4-0.3-0.2-0.3-0.2-0.2-0.4-0.2-0.1
Delay disc. indifference point, 24s delay0.80.91.91.40.81.21.11.01.00.60.90.90.50.8
Delay disc. indifference point, 4s delay0.00.00.1-0.00.20.00.10.20.20.20.20.10.20.2
Delay disc. indifference point, 8s delay1.11.32.2-1.5-1.3-1.1-1.0-1.1-1.0-1.3-1.0-1.0-1.3-0.6
Indifference point function ln k0.50.81.91.41.10.70.80.80.91.00.71.01.10.1
Indifference point function log k0.50.81.91.41.10.70.80.80.91.00.71.01.10.1
Patch foraging total patch changes 0 sec0.30.60.80.90.80.70.70.70.80.70.70.80.80.6
Patch foraging total patch changes 12 sec0.20.20.50.20.30.50.50.50.40.40.50.30.40.7
Patch foraging total patch changes 18 sec0.40.72.0-1.4-1.0-0.7-0.6-0.6-0.6-1.0-0.5-0.8-1.00.3
Patch foraging total patch changes 24 sec0.20.40.90.60.50.70.70.60.50.50.60.40.60.9
Patch foraging total patch changes 6 sec0.00.10.2-0.10.00.30.20.20.20.00.30.00.00.5
Patch foraging time to switch 0 sec0.91.82.3-1.3-1.4-1.2-1.4-1.3-1.4-1.5-1.3-1.4-1.5-1.3
Patch foraging water rate 0 sec0.30.61.20.1-0.7-0.7-0.7-0.8-0.8-0.8-0.9-0.8-0.6-1.1
Patch foraging water rate 12 sec0.71.43.31.81.11.31.31.21.30.81.11.31.00.7
Patch foraging water rate 18 sec0.40.71.4-0.1-0.7-0.8-0.8-0.9-0.9-0.7-1.0-0.9-0.6-1.2
Patch foraging water rate 24 sec0.50.81.61.20.90.70.80.81.10.70.81.10.80.4
Patch foraging water rate 6 sec0.10.21.11.00.30.30.30.20.30.20.10.30.2-0.1
Seeking ratio, delayed vs. immediate footshock1.01.21.80.91.11.21.11.21.11.01.21.11.01.3
Distance traveled before self-admin2.33.03.61.71.91.81.71.71.71.91.71.71.71.5
Distance traveled after self-admin2.53.14.01.71.91.81.81.81.62.01.81.61.71.5
Extensor digitorum longus weight0.20.81.1-0.8-0.8-1.0-0.9-0.9-0.9-0.7-0.9-0.9-0.8-1.0
Bone: elastic displacement0.00.00.1-0.0-0.2-0.1-0.1-0.2-0.30.1-0.2-0.3-0.2-0.2
Bone: elastic work2.73.54.32.11.92.02.01.81.82.01.81.81.81.7
Bone: endosteal estimation0.81.73.01.01.11.41.31.41.31.01.41.31.11.7
Bone: endosteal perimeter0.71.42.01.11.11.31.21.31.20.91.31.21.11.4
Epididymis fat weight0.00.00.10.30.00.10.10.10.00.1-0.00.1-0.1-0.2
Delta time in closed arm before/after self-admin0.10.10.40.50.0-0.1-0.2-0.1-0.2-0.0-0.2-0.1-0.2-0.6
Delta time in open arm before/after self-admin0.20.20.40.20.50.30.40.40.40.50.40.30.60.5
Diff in mean of infusions in LGA sessions0.10.10.4-0.5-0.30.10.2-0.1-0.0-0.30.10.0-0.30.6
Delay discount exponential model param0.00.00.10.10.0-0.1-0.1-0.1-0.20.0-0.1-0.10.1-0.3
Extinction: sum of active levers before priming2.12.33.71.11.41.61.61.51.51.31.61.51.51.9
Active lever presses in extinction session 60.10.10.5-0.10.30.40.40.30.30.50.40.20.20.7
Bone: final force1.72.72.91.61.61.71.71.71.71.51.71.71.61.7
Bone: final moment2.74.34.62.02.02.12.12.12.12.02.12.12.02.1
Food consumed during 24 hour testing period0.30.41.21.10.60.60.60.50.60.50.50.60.50.4
Glucose0.20.41.30.4-0.5-0.4-0.5-0.5-0.6-0.6-0.6-0.5-0.7-1.2
Heart weight1.11.72.21.41.21.51.41.21.21.11.21.21.21.5
Delay discount hyperbolic model param0.00.00.10.30.10.10.10.1-0.00.10.00.10.2-0.1
Intermittent access intake day 1-15 change0.20.40.50.60.70.60.50.70.60.70.60.60.60.4
Intermittent access intake escalation0.10.20.40.40.60.50.40.50.40.60.50.50.60.3
Intermittent access intake escalation 21.92.22.90.71.41.41.41.61.61.51.61.51.51.7
Intermitt. access day 1 inactive lever presses1.14.26.12.52.22.12.12.12.02.01.92.21.91.6
Intermitt. access day 15 inactive lever presses0.51.02.41.51.11.00.90.90.91.00.81.00.90.4
Intermitt. access escalation Index0.40.50.90.00.70.50.70.70.80.90.80.60.91.0
Intermittent access day 1 total infusions0.10.10.70.60.4-0.2-0.1-0.10.10.5-0.10.10.3-0.8
Intermittent access day 15 total infusions0.30.50.90.90.90.50.50.60.71.00.50.70.9-0.1
Intermittent access terminal intake (last 3 days)1.01.41.91.31.41.11.11.11.21.41.11.21.30.6
Intermittent access total infusions0.30.40.90.90.80.30.30.40.50.80.30.60.7-0.3
Intermittent access day 1 locomotion0.30.41.10.80.90.20.30.40.51.10.30.60.9-0.3
Intermittent access day 15 total locomotion0.00.10.30.50.2-0.0-0.10.10.10.3-0.00.10.1-0.6
Intermittent access total locomotion0.10.10.90.30.1-0.4-0.4-0.2-0.20.2-0.3-0.10.0-0.9
Intermittent access standard deviation1.53.24.51.11.71.81.81.81.91.71.91.91.72.1
Left kidney weight3.215.016.33.73.94.04.04.03.84.03.93.73.83.8
Right kidney weight3.314.916.23.83.93.94.03.93.84.03.83.83.83.7
Cocaine induced anxiety0.40.61.3-1.1-0.8-0.8-0.7-0.8-0.7-0.8-0.7-0.7-0.8-0.3
Post-drug Anxiety0.10.10.3-0.5-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.20.3
Baseline Anxiety1.61.82.71.61.41.41.31.41.31.41.31.31.41.0
Tail length4.718.522.14.74.24.74.54.54.23.94.34.24.04.1
Length with tail6.428.035.45.95.25.75.55.45.24.95.25.25.04.9
Length without tail1.55.06.12.52.12.42.32.32.22.02.22.21.92.2
Times rat made contact with spout0.40.51.1-1.0-0.8-0.7-0.6-0.6-0.6-0.7-0.6-0.6-0.7-0.2
Lifetime Intake0.10.20.40.70.60.10.10.20.30.60.10.30.5-0.6
Liver weight, left0.20.30.30.60.50.50.50.60.50.60.50.50.50.4
Liver weight, right0.00.10.30.50.20.30.20.30.20.00.20.20.2-0.1
Locomotor activity0.61.01.6-1.1-1.2-0.7-0.9-0.9-1.0-1.3-0.8-1.1-1.3-0.5
Locomotor testing distance1.22.12.7-1.7-1.6-1.4-1.4-1.5-1.5-1.6-1.4-1.5-1.5-1.0
Locomotor testing rearing1.22.55.8-2.4-1.7-1.5-1.5-1.5-1.5-1.5-1.4-1.6-1.4-0.7
Locomotion in novel chamber0.60.81.7-1.3-0.9-1.0-1.0-0.8-0.8-0.8-0.8-0.8-0.7-0.6
Locomotion in novel chamber post-restriction0.00.00.10.1-0.20.00.0-0.1-0.1-0.3-0.1-0.1-0.2-0.0
Fecal boli incidents, locomotor time 12.63.86.8-1.3-1.7-2.1-2.1-1.9-2.1-1.5-2.1-2.0-1.5-2.6
Change in fecal boli incidents, locomotor task0.10.10.8-0.9-0.1-0.10.10.00.20.00.20.0-0.10.7
Time >=10cm from walls, locomotor time 10.00.00.1-0.0-0.1-0.1-0.1-0.2-0.3-0.1-0.2-0.2-0.1-0.2
Bouts of movement, locomotor time 10.10.20.30.00.30.40.50.40.30.50.40.20.60.5
Total resting periods, locomotor time 10.10.10.30.10.30.20.30.20.10.50.20.10.50.2
Rest time, locomotor task time 10.10.10.50.00.0-0.4-0.3-0.3-0.40.1-0.4-0.20.2-0.7
Distance moved, locomotor task time 10.10.20.50.10.10.50.40.50.70.00.50.4-0.10.7
Vertical activity count, locomotor time 10.61.42.30.81.01.31.21.31.41.01.41.20.81.5
Time >=10cm from walls, locomotor time 20.00.00.20.0-0.10.30.30.10.0-0.10.1-0.1-0.10.4
Bouts of movement, locomotor time 20.30.51.0-0.1-0.6-0.6-0.5-0.9-1.0-0.5-0.9-0.9-0.5-0.9
Total resting periods, locomotor time 20.30.61.0-0.2-0.7-0.7-0.6-0.9-1.0-0.6-1.0-0.9-0.6-0.9
Rest time, locomotor task time 20.40.50.80.80.90.70.70.70.70.80.60.90.80.4
Distance moved, locomotor task time 20.10.20.5-0.7-0.5-0.2-0.3-0.3-0.2-0.5-0.2-0.4-0.50.2
Vertical activity count, locomotor time 20.10.10.4-0.40.00.20.10.30.20.20.4-0.00.00.6
Light reinforcement 10.20.40.8-0.6-0.8-0.6-0.6-0.6-0.6-0.9-0.6-0.6-0.8-0.4
Light reinforcement 25.99.111.4-2.3-3.0-3.1-3.1-3.0-3.0-3.1-3.1-2.9-3.2-3.4
Bone: marrow area0.81.83.31.01.21.41.41.51.41.01.51.31.21.8
Bone: maximum diameter1.52.93.41.81.71.71.71.71.71.51.71.71.71.6
Bone: maximum force3.25.66.62.02.32.42.42.42.42.32.52.42.42.6
Bone: maximum moment4.27.48.52.32.72.72.82.82.82.62.82.82.72.9
Mean time between licks in bursts0.20.40.50.60.70.50.60.50.70.70.50.70.70.4
Mean num. licks in bursts0.50.82.00.10.71.00.91.00.90.71.10.90.81.4
Cd content in liver0.70.82.5-1.6-0.9-1.0-0.9-0.8-0.8-0.7-0.7-0.8-0.9-0.4
Co content in liver0.80.91.6-0.7-0.8-1.0-1.0-1.0-1.0-0.7-1.0-1.0-0.9-1.3
Cu content in liver1.41.74.02.01.41.41.31.11.11.41.01.21.10.8
Fe content in liver1.01.21.8-0.6-1.0-1.1-1.1-1.1-1.2-0.8-1.2-1.2-1.2-1.3
K content in liver0.90.81.81.30.91.00.90.90.80.90.80.90.80.7
Mg content in liver0.30.31.21.10.50.50.50.30.30.60.20.40.30.1
Mn content in liver1.01.11.41.01.11.01.01.01.01.21.01.01.11.0
Na content in liver3.13.34.42.11.82.01.91.91.81.61.81.81.81.6
Rb content in liver0.00.00.10.30.10.10.1-0.0-0.00.3-0.0-0.0-0.10.1
Se content in liver2.32.73.1-1.6-1.6-1.7-1.8-1.7-1.7-1.3-1.6-1.6-1.6-1.7
Sr content in liver0.30.20.4-0.3-0.5-0.5-0.5-0.5-0.4-0.6-0.5-0.4-0.4-0.6
Zn content in liver1.82.02.8-0.8-1.3-1.3-1.4-1.5-1.5-1.2-1.6-1.5-1.6-1.7
Bone: minimum diameter5.710.515.42.13.13.23.23.33.33.03.53.33.33.9
Time in familiar zone, hab. session 10.20.20.40.20.40.40.40.50.50.40.50.50.40.6
Time in novel zone, hab. session 10.10.10.1-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.3
Total zone transitions, hab. session 10.50.71.6-0.10.70.70.70.80.80.80.90.81.01.2
Total locomotion distance, hab. session 12.53.56.60.81.71.81.91.91.91.72.11.91.92.6
Locomotion velocity, hab. session 11.01.43.30.31.01.11.21.21.21.01.31.21.21.8
Time in familiar zone, hab. session 20.30.30.40.50.60.50.50.60.60.50.60.60.60.5
Time in novel zone, hab. session 20.60.60.9-0.7-0.9-0.7-0.7-0.7-0.8-1.0-0.7-0.8-0.8-0.6
Total zone transitions, hab. session 20.00.00.0-0.20.0-0.1-0.1-0.10.0-0.0-0.00.00.0-0.0
Total locomotion distance, hab. session 20.50.61.10.30.70.70.80.70.80.70.80.80.81.1
Locomotion velocity, hab. session 20.40.51.00.30.70.70.80.70.80.70.80.80.71.0
Novel to familiar place preference ratio0.90.91.60.40.81.11.01.10.90.81.20.90.91.3
Novelty place preference0.70.81.30.40.71.00.91.00.80.71.00.80.81.1
Time in novel zone, NPP test0.40.40.90.20.50.80.70.80.60.40.80.60.60.9
Total zone transitions, NPP test0.10.20.3-0.5-0.4-0.6-0.5-0.4-0.4-0.3-0.4-0.4-0.3-0.6
Total locomotion distance, NPP test1.41.93.10.71.31.31.41.41.41.41.51.41.41.8
Locomotion velocity, NPP test1.92.63.90.91.61.51.61.61.71.61.71.61.72.0
Intraocular pressure0.10.10.60.1-0.3-0.3-0.4-0.3-0.4-0.2-0.4-0.5-0.2-0.7
Delta distance traveled before/after self-admin0.20.20.3-0.2-0.4-0.3-0.4-0.4-0.5-0.3-0.4-0.6-0.4-0.3
Delta ambulatory time before/after self-admin0.00.00.10.10.10.10.10.20.10.20.20.10.20.2
Parametrial fat weight0.10.20.4-0.2-0.5-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.5-0.6
Pavlov. Cond. lever latency0.40.50.7-0.8-0.8-0.7-0.7-0.7-0.7-0.8-0.7-0.7-0.8-0.6
Pavlov. Cond. magazine entry latency0.10.20.3-0.3-0.3-0.6-0.4-0.5-0.4-0.0-0.5-0.4-0.3-0.5
Pavlov. Cond. change in total contacts0.00.00.10.20.1-0.00.00.00.00.2-0.00.00.1-0.1
Pavlov. Cond. index score0.00.10.20.30.30.10.20.20.20.50.10.20.30.1
Pavlov. Cond. latency score0.10.10.30.40.40.20.30.30.30.50.30.30.40.3
Pavlov. Cond. lever contacts0.91.11.51.21.11.01.01.01.01.21.01.11.10.8
Pavlov. Cond. magazine entry number0.00.00.10.20.00.30.20.20.1-0.30.20.10.10.2
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.6-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.40.40.20.30.20.30.60.20.30.40.1
Pavlov. Cond. response bias0.10.10.50.40.40.10.20.20.20.70.20.20.30.1
Pavlov. Cond. lever latency3.75.05.9-2.2-2.4-2.1-2.2-2.2-2.3-2.4-2.2-2.3-2.3-2.0
Pavlov. Cond. magazine entry latency2.22.74.82.21.81.61.61.51.61.81.41.61.61.0
Pavlov. Cond. change in total contacts5.28.49.42.63.02.82.92.82.93.12.92.92.92.8
Pavlov. Cond. index score3.44.65.62.32.32.12.12.12.12.42.02.12.21.7
Pavlov. Cond. latency score3.04.05.12.32.21.92.01.92.02.21.92.02.11.5
Pavlov. Cond. lever contacts4.05.56.52.22.52.22.32.32.42.52.32.42.42.1
Pavlov. Cond. magazine entry number1.31.62.6-1.6-1.4-1.2-1.2-1.2-1.2-1.4-1.1-1.2-1.3-0.8
Pavlov. Cond. intertrial magazine entries0.91.32.3-0.6-1.3-1.0-1.0-1.2-1.2-1.5-1.2-1.2-1.3-1.1
Pavlov. Cond. lever-magazine prob. diff.3.64.85.82.42.42.22.22.22.22.42.12.22.31.7
Pavlov. Cond. response bias4.96.78.12.52.82.52.52.62.62.82.62.62.72.3
Time in closed arm before self-admin0.00.00.1-0.3-0.1-0.00.1-0.00.3-0.20.10.20.00.1
Time in closed arm after self-admin0.00.00.20.40.1-0.1-0.0-0.10.10.0-0.10.20.1-0.4
Time in open arm before self-admin0.70.81.61.30.91.00.90.90.70.90.80.70.80.8
Time in open arm after self-admin1.71.93.11.11.31.51.41.41.21.41.41.11.41.7
Bone: periosteal estimation2.14.46.71.62.02.22.22.22.11.92.22.12.02.6
Bone: periosteal perimeter1.83.14.71.41.71.81.81.81.81.51.91.81.72.2
Bone: post-yield work0.81.21.80.61.11.01.11.11.11.11.21.11.11.3
Progressive ratio test 1 active lever presses1.11.32.41.41.50.80.81.01.11.50.91.21.40.1
Progressive ratio test 1 breakpoint1.31.62.81.61.61.01.01.21.31.71.11.31.50.3
Progressive ratio test 1 inactive lever presses0.91.42.31.51.41.01.01.11.11.40.91.21.30.3
Progressive ratio test 2 active lever presses0.10.10.70.60.3-0.2-0.2-0.1-0.10.3-0.20.10.3-0.8
Progressive ratio test 2 breakpoint0.10.10.70.60.3-0.2-0.2-0.1-0.10.3-0.30.10.2-0.8
Progressive ratio test 2 inactive lever presses0.61.02.61.61.20.90.90.90.91.20.70.91.00.1
Incentive Sensitization - Responses0.40.60.9-0.3-0.8-0.7-0.7-0.8-0.8-0.9-0.9-0.8-0.8-0.9
Incentive Sensitization - Breakpoint0.50.70.9-0.4-0.8-0.7-0.8-0.8-0.8-0.9-0.9-0.8-0.9-0.9
Sum of active levers in priming session hrs 5-60.20.21.2-1.1-0.3-0.1-0.0-0.1-0.0-0.20.0-0.1-0.20.9
Progressive ratio0.81.31.9-1.4-1.1-1.2-1.1-1.1-1.1-1.2-1.0-1.1-1.3-0.8
Food seeking constrained by brief footshock2.32.83.61.11.61.61.71.71.81.71.81.81.91.8
Seeking ratio, punishment vs. effort1.72.43.21.81.51.61.51.51.51.61.41.61.81.3
Retroperitoneal fat weight0.41.82.1-0.9-1.4-1.2-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.4
Reaction time number correct0.00.10.10.30.30.20.30.30.30.20.30.40.40.3
Reaction time mean minus median0.10.30.60.80.50.60.60.50.50.40.50.50.50.5
Reaction time mean minus median AUC0.20.51.41.20.60.70.80.60.60.60.50.50.70.5
Reaction time num false alarms0.81.11.7-1.2-0.9-1.3-1.2-1.0-1.1-0.7-1.1-1.0-0.9-1.1
Reaction time num false alarms AUC1.11.62.4-1.5-1.2-1.5-1.4-1.3-1.3-0.9-1.3-1.2-1.1-1.3
Reaction time trials correct on left0.00.10.10.30.30.20.30.30.30.20.30.40.40.3
Reaction time trials on left0.00.10.10.30.30.20.30.30.30.20.20.30.30.2
Reaction time mean0.00.10.20.2-0.1-0.1-0.2-0.2-0.2-0.2-0.3-0.2-0.1-0.5
Reaction time mean AUC0.10.20.50.3-0.3-0.3-0.3-0.4-0.4-0.3-0.5-0.3-0.2-0.7
Median of all reaction times0.20.30.8-0.2-0.5-0.6-0.6-0.6-0.6-0.5-0.7-0.5-0.5-0.9
Reaction time omissions0.20.30.4-0.3-0.5-0.4-0.5-0.5-0.6-0.5-0.6-0.6-0.4-0.7
Reaction time false alarm rate1.11.52.0-1.3-1.1-1.4-1.3-1.2-1.2-0.9-1.2-1.2-1.1-1.3
Reaction time premature initiation rate0.00.00.1-0.20.0-0.10.00.00.10.10.00.1-0.00.2
Reaction time premature initiations0.00.00.1-0.10.10.00.10.10.20.20.10.20.20.3
Std. dev. reaction times0.10.20.70.80.40.50.50.30.40.40.30.40.40.2
Reaction time trials completed0.00.10.10.30.30.20.30.30.30.20.20.30.30.2
Reaction time trials AUC0.00.00.10.20.20.10.20.20.20.10.10.30.30.1
Run reversals in cocaine runway, females0.20.20.60.4-0.3-0.2-0.3-0.4-0.4-0.2-0.5-0.4-0.2-0.7
Run reversals in cocaine runway, males0.80.81.2-1.0-1.0-0.9-0.9-0.9-0.8-1.1-0.9-0.8-1.1-0.7
Latency to leave start box in cocaine runway0.10.10.3-0.1-0.4-0.1-0.2-0.2-0.2-0.5-0.2-0.2-0.6-0.1
Latency to leave start box in cocaine runway, F0.30.40.8-0.5-0.7-0.5-0.5-0.6-0.5-0.9-0.5-0.5-0.9-0.2
Latency to leave start box in cocaine runway, M0.00.00.10.30.10.20.20.30.20.20.20.20.00.0
Std. dev. time between licks in bursts0.50.60.90.40.80.70.70.80.90.90.90.90.80.8
Total sessions with >9 infusions0.10.10.4-0.70.0-0.6-0.5-0.2-0.10.2-0.2-0.10.3-0.5
Short access day 1 total inactive lever presses0.60.81.41.21.00.80.90.91.00.80.81.10.80.5
Short access day 10 total inactive lever presses0.92.23.41.81.51.51.51.51.51.41.41.61.31.2
Short access day 1 total infusions0.91.21.71.11.20.91.01.01.11.21.01.01.30.8
Short access day 10 total infusions0.00.00.10.20.3-0.1-0.00.10.20.30.00.20.4-0.3
Short access total infusions0.10.10.30.10.3-0.2-0.10.00.20.5-0.00.10.5-0.5
Short access day 1 locomotion0.91.11.4-1.2-1.0-1.2-1.1-1.1-1.1-0.9-1.1-1.2-0.8-1.0
Short access day 10 total locomotion0.71.42.30.71.40.90.91.11.11.51.11.31.50.9
Short access total locomotion0.10.10.5-0.30.5-0.2-0.10.10.20.70.20.30.6-0.1
One hour access (0.3 mA shock)0.70.81.10.81.10.60.70.91.01.00.81.01.00.3
Compulsive drug intake2.22.64.70.61.41.51.61.71.71.51.91.71.42.2
One hour access (shock baseline)0.10.10.60.50.3-0.2-0.2-0.1-0.00.3-0.20.10.2-0.8
Social response proportion4.75.35.92.22.32.42.42.42.42.22.42.32.32.0
Social responses0.10.10.50.70.20.40.30.30.20.00.20.10.3-0.1
Social time0.20.30.70.20.40.60.50.50.40.40.60.40.70.8
Soleus weight0.82.44.9-2.2-1.5-1.7-1.6-1.6-1.5-1.3-1.4-1.6-1.4-1.0
Bone: stiffness1.62.63.11.01.61.51.51.71.71.51.71.71.71.8
Tibialis anterior weight0.00.10.8-0.9-0.1-0.4-0.2-0.1-0.10.1-0.0-0.20.10.3
Time to tail flick, vehicle, before self-admin0.10.10.50.70.30.30.20.20.20.20.10.20.1-0.2
Time to tail flick, vehicle, after self-admin0.30.41.61.30.70.80.70.60.50.70.50.50.5-0.0
Time to tail flick, test, before self-admin0.30.30.5-0.4-0.7-0.4-0.5-0.5-0.5-0.7-0.5-0.6-0.6-0.4
Time to tail flick, test, after self-admin0.10.10.1-0.0-0.1-0.3-0.3-0.3-0.3-0.0-0.3-0.2-0.1-0.3
Delta time to tail flick, vehicle, before/after SA0.30.30.50.70.60.50.60.50.50.60.50.50.50.3
Delta time to tail flick, test, before/after SA0.00.00.10.30.30.10.10.10.10.40.10.20.3-0.1
Tibia length2.15.77.52.72.42.52.52.42.32.22.32.42.22.2
Ambulatory time before self-admin1.42.12.51.31.51.51.51.51.41.61.51.51.41.3
Ambulatory time after self-admin2.63.03.51.71.81.81.81.81.71.91.81.71.71.6
Bone: tissue strength4.74.85.11.92.22.12.22.22.32.22.22.22.22.1
Total heroin consumption1.11.33.3-0.11.10.91.11.11.11.21.21.11.11.8
Bone: trabecular number0.10.10.40.60.30.40.40.40.30.20.30.30.40.1
Bone: trabecular spacing1.82.33.01.01.61.51.51.51.61.71.61.61.61.6
Bone: trabecular thickness0.10.10.30.3-0.3-0.2-0.2-0.3-0.4-0.4-0.4-0.4-0.3-0.6
Bone: trabecular tissue density2.63.84.2-2.0-2.1-1.9-2.0-1.9-2.0-2.0-1.9-2.0-2.0-1.7
Water consumed over 24 hours0.91.21.61.31.11.11.11.11.01.11.01.11.10.9
Number of responses in last shaping day0.50.60.70.80.70.80.80.80.80.50.80.80.60.8