Hub : Genes

Samm50

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Samm50 0.11 0.06 1.0e-14 0.05 0.09 0.09 0.09 1.4e-08 2.2e-13 1.8e-13 1.4e-13
2 Brain gene expression Samm50 0.46 0.04 0.0e+00 0.16 0.26 0.25 0.25 8.2e-15 8.4e-24 6.9e-23 2.1e-23
3 pVTA gene expression Samm50 0.16 0.08 1.3e-09 0.1 0.11 0.11 0.11 1.9e-08 2.4e-09 5.2e-09 4.5e-09
4 BLA gene expression Samm50 0.38 0.14 1.7e-14 0.13 0.2 0.19 0.19 2.6e-07 7.5e-11 3.3e-10 1.5e-10
5 Liver gene expression Samm50 0.07 0.04 9.8e-06 0.04 0.03 0.04 0.04 3.0e-05 6.1e-04 2.1e-05 8.7e-05
6 PL gene expression Samm50 0.22 0.1 0.0e+00 0.14 0.15 0.14 0.16 2.1e-15 8.8e-16 1.5e-14 4.3e-17
7 IC gene expression Samm50 0.15 0.1 2.1e-03 0.04 0.06 0.07 0.05 9.2e-03 2.3e-03 6.3e-04 3.9e-03
8 IL gene expression Samm50 0.26 0.13 5.6e-04 0.1 0.14 0.08 0.15 2.1e-03 2.9e-04 6.4e-03 2.2e-04
9 NAcc mRNA stability Samm50 0.03 0.02 2.1e-03 0.03 0.01 0.02 0.02 7.5e-05 4.1e-03 1.7e-03 5.8e-04
10 PL mRNA stability Samm50 0.04 0.03 5.3e-03 0.03 0.02 0.03 0.03 4.7e-04 2.5e-03 7.7e-04 7.3e-04
11 pVTA mRNA stability Samm50 0.06 0.04 6.3e-03 0.03 0.02 0.02 0.02 1.2e-03 1.4e-02 1.0e-02 8.1e-03
12 Brain mRNA stability Samm50 0.17 0.09 1.2e-09 0.1 0.1 0.1 0.1 3.8e-09 5.9e-10 1.9e-09 1.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.30.70.50.50.70.40.80.60.70.5-0.3-0.6-0.4-0.1
Area under the delay curve1.41.72.81.61.71.71.71.41.51.51.6-0.5-0.3-0.0-0.0
BMI with tail0.92.94.4-2.1-2.1-2.0-1.8-2.0-1.8-1.5-1.51.61.71.11.1
BMI without tail0.30.91.7-1.2-1.2-1.3-1.3-1.3-1.2-0.5-1.20.00.1-0.2-0.1
Body weight0.72.94.7-2.2-2.2-2.1-1.6-2.1-2.0-1.3-1.41.51.40.91.1
Weight adjusted by age0.61.02.2-1.1-1.1-1.1-0.7-1.2-1.2-1.5-1.4-0.30.5-0.3-0.4
Bone surface0.10.10.30.30.30.40.20.50.30.40.40.1-0.1-0.30.1
Bone volume0.00.10.20.20.10.3-0.00.40.20.20.2-0.1-0.4-0.3-0.1
Breakpoint value in progressive ratio session0.20.20.4-0.6-0.6-0.5-0.1-0.6-0.7-0.6-0.40.20.30.6-0.0
Number of licking bursts0.30.41.40.60.50.4-0.10.40.30.60.2-1.2-0.9-0.8-1.0
Context. condit. distance diff. score2.22.74.6-1.8-1.8-1.9-2.2-1.6-1.6-1.8-1.21.31.41.61.0
Locomotion velocity, session 11.41.52.5-1.3-1.3-1.1-0.6-1.1-1.1-1.5-0.81.21.41.60.9
Locomotion distance, session 10.10.20.50.30.40.40.40.50.40.00.40.30.50.70.4
Locomotion velocity, session 23.74.37.9-2.7-2.7-2.6-1.8-2.8-2.6-2.2-2.60.20.10.2-0.3
Locomotion distance, session 20.40.52.00.50.50.71.40.60.60.30.70.70.70.90.7
Locomotion velocity, session 32.32.64.3-2.0-2.0-2.0-1.7-2.1-2.0-1.7-2.00.1-0.0-0.0-0.4
Locomotion distance, session 30.91.02.4-0.4-0.4-0.5-0.5-0.7-0.7-0.2-1.0-1.5-1.5-1.6-1.5
Stereotopy head waving bouts, day 31.51.72.6-1.6-1.6-1.3-0.5-1.3-1.3-1.5-0.91.61.21.40.9
Stereotopy head waving duration, day 33.33.95.9-2.4-2.4-2.2-1.8-2.1-2.1-2.3-1.71.81.51.81.1
Locomotion velocity, session 70.50.51.3-0.8-0.8-1.0-0.6-1.1-1.0-0.6-0.9-0.3-0.3-0.2-0.5
Locomotion distance, session 70.10.10.40.30.30.30.60.10.10.00.2-0.3-0.2-0.1-0.3
Stereotopy head waving bouts, day 73.74.27.2-2.6-2.6-2.7-2.5-2.6-2.5-2.1-2.40.10.40.4-0.1
Stereotopy head waving duration, day 72.83.46.3-2.2-2.2-2.4-2.5-2.3-2.2-1.9-2.2-0.50.00.2-0.5
Locomotion velocity, session 85.66.89.9-3.1-3.1-2.9-2.2-2.8-2.5-3.0-2.22.32.42.71.7
Locomotion distance, session 81.31.92.9-1.7-1.7-1.7-1.4-1.6-1.6-1.6-1.40.81.01.20.5
Degree of sensitization distance1.31.34.10.00.10.20.60.30.4-0.30.81.91.92.01.8
Degree of sensitization stereotypy2.83.16.5-2.1-2.1-2.3-2.5-2.1-2.1-1.6-2.1-0.4-0.00.1-0.4
Conditioned locomotion0.20.30.50.60.50.3-0.10.40.30.70.3-0.7-0.7-0.6-0.4
Cocaine response after cond. corrected0.30.40.9-0.3-0.4-0.6-1.0-0.4-0.5-0.2-0.6-0.9-0.8-0.7-0.9
Cocaine response after cond. not corrected0.91.12.2-0.4-0.6-0.8-1.4-0.7-0.8-0.2-0.9-1.5-1.3-1.3-1.4
Cocaine response before conditioning0.20.30.90.40.40.3-0.00.30.40.70.1-0.7-0.7-0.9-0.4
Saline control response0.40.61.3-0.7-0.7-0.7-1.2-0.6-0.8-0.2-0.9-0.6-0.6-0.9-0.8
Bone: connectivity density0.00.10.20.20.20.30.10.40.30.30.2-0.2-0.4-0.2-0.1
Bone: cortical apparent density1.01.43.11.51.41.61.81.51.31.11.4-0.10.00.00.1
Bone: cortical area0.40.61.8-0.7-0.9-1.0-1.3-0.9-0.9-0.8-0.9-0.0-0.20.0-0.0
Bone: cortical porosity0.20.20.4-0.2-0.2-0.4-0.6-0.4-0.3-0.4-0.4-0.4-0.6-0.1-0.5
Bone: cortical porosity0.40.41.1-0.6-0.7-0.8-1.1-0.7-0.6-0.7-0.7-0.1-0.30.1-0.2
Bone: cortical thickness0.40.71.21.00.91.00.91.11.00.41.10.30.30.60.7
Bone: cortical thickness0.60.62.40.40.40.50.40.70.7-0.30.81.00.91.61.1
Bone: cortical tissue density0.91.22.81.31.31.41.71.41.20.91.30.00.20.10.2
Condit. Reinf. active minus inactive responses1.51.63.11.81.71.61.71.51.61.11.4-0.20.1-0.2-0.1
Condit. Reinf. active-inactive response ratio0.91.02.11.41.31.20.61.31.31.01.2-0.10.2-0.00.1
Condit. Reinf. active responses1.31.63.41.71.61.61.81.31.41.11.1-0.8-0.6-0.8-0.8
Condit. Reinf. inactive responses0.40.41.80.60.60.71.30.30.40.40.3-0.6-0.7-0.6-0.7
Incentive salience index mean1.51.83.81.81.71.72.01.51.61.21.4-0.4-0.1-0.5-0.3
Condit. Reinf. lever presses0.50.72.81.00.91.01.70.70.80.70.7-0.3-0.1-0.6-0.4
Condit. Reinf. active minus inactive responses0.60.81.70.60.60.81.10.80.70.51.01.30.91.01.3
Condit. Reinf. active-inactive response ratio0.30.40.80.40.40.50.60.60.50.20.60.70.50.90.8
Condit. Reinf. active responses0.60.83.5-0.3-0.20.00.50.0-0.00.10.41.91.31.21.7
Condit. Reinf. inactive responses0.60.82.9-0.7-0.6-0.40.0-0.5-0.3-0.5-0.11.71.41.01.5
Condit. Reinf. lever presses0.20.30.6-0.5-0.5-0.30.7-0.6-0.5-0.4-0.20.80.60.30.6
Condit. Reinf. lever reinforcers received0.50.72.40.10.20.40.90.30.30.30.61.51.10.91.5
Conditioned reinforcement - actives0.10.10.50.10.20.30.40.40.20.70.30.50.2-0.00.3
Conditioned reinforcement - inactives0.30.51.8-0.2-0.3-0.00.1-0.1-0.10.60.10.81.31.30.9
Conditioned locomotion1.62.13.6-1.9-1.8-1.7-1.5-1.8-1.8-1.6-1.80.40.10.4-0.5
Patch foraging indifference point 0 sec0.00.10.30.20.30.30.30.60.20.20.3-0.2-0.2-0.1-0.1
Patch foraging indifference point AUC0.60.81.51.01.01.11.21.11.10.61.10.60.50.60.7
Delay disc. indifference point, 0s delay0.50.50.9-0.7-0.8-0.9-0.9-0.8-0.9-0.9-0.7-0.2-0.3-0.0-0.4
Delay disc. indifference point, 16s delay1.51.73.91.61.71.72.01.31.41.11.4-0.7-0.5-0.2-0.2
Delay disc. indifference point, 2s delay0.70.82.40.91.01.10.91.01.01.61.0-0.1-0.00.40.1
Delay disc. indifference point, 24s delay0.91.02.31.21.21.21.50.81.11.41.3-0.10.2-0.00.4
Delay disc. indifference point, 4s delay0.90.91.60.80.91.10.91.01.00.91.30.80.81.20.9
Delay disc. indifference point, 8s delay1.92.23.71.91.91.81.81.61.61.71.6-1.0-0.8-0.4-0.4
Indifference point function ln k1.22.13.6-1.8-1.7-1.8-1.9-1.7-1.9-1.1-1.7-0.3-0.4-0.6-0.7
Indifference point function log k1.22.13.6-1.8-1.7-1.8-1.9-1.7-1.9-1.1-1.7-0.3-0.4-0.6-0.7
Patch foraging total patch changes 0 sec0.10.10.30.30.30.30.20.60.20.20.3-0.4-0.4-0.3-0.4
Patch foraging total patch changes 12 sec0.40.51.10.30.40.50.60.70.60.20.81.00.90.81.0
Patch foraging total patch changes 18 sec0.30.51.30.80.81.00.61.20.90.40.90.2-0.00.20.2
Patch foraging total patch changes 24 sec0.40.61.2-0.8-0.8-0.8-0.6-0.8-1.1-0.7-1.0-0.6-0.8-0.6-0.9
Patch foraging total patch changes 6 sec0.60.92.00.91.01.10.71.41.10.41.40.90.40.80.7
Patch foraging time to switch 0 sec0.20.40.8-0.7-0.6-0.5-0.1-0.8-0.6-0.7-0.9-0.5-0.3-0.3-0.7
Patch foraging water rate 0 sec0.10.10.7-0.3-0.4-0.5-0.8-0.2-0.4-0.2-0.10.20.20.30.4
Patch foraging water rate 12 sec1.42.95.2-1.6-1.7-1.9-2.3-1.9-2.0-0.9-2.0-1.1-1.6-1.4-1.5
Patch foraging water rate 18 sec0.00.10.30.20.00.1-0.10.2-0.00.60.10.1-0.3-0.5-0.0
Patch foraging water rate 24 sec1.11.62.8-1.6-1.7-1.6-1.5-1.6-1.6-1.2-1.40.40.10.20.0
Patch foraging water rate 6 sec0.40.52.80.40.20.1-0.10.2-0.11.1-0.0-1.0-0.8-1.7-0.8
Seeking ratio, delayed vs. immediate footshock0.91.13.21.11.00.90.60.80.60.50.4-1.8-1.6-1.1-1.4
Distance traveled before self-admin0.30.40.70.80.80.80.80.80.80.10.6-0.0-0.10.00.1
Distance traveled after self-admin0.00.00.2-0.2-0.3-0.1-0.0-0.2-0.3-0.5-0.20.10.00.20.1
Extensor digitorum longus weight0.41.62.9-1.4-1.5-1.5-1.1-1.7-1.6-1.4-1.7-0.7-0.2-0.3-0.8
Bone: elastic displacement1.21.32.6-1.5-1.5-1.5-1.6-1.4-1.4-1.0-1.30.0-0.10.3-0.1
Bone: elastic work3.74.88.2-2.9-2.9-2.8-2.6-2.7-2.6-2.1-2.30.90.70.90.5
Bone: endosteal estimation3.06.611.3-3.2-3.3-3.4-3.2-3.3-3.2-2.4-3.00.50.1-0.1-0.3
Bone: endosteal perimeter3.37.112.1-2.9-3.1-3.4-3.5-3.3-3.3-2.2-3.4-0.8-1.2-1.2-1.4
Epididymis fat weight0.10.51.5-0.5-0.5-0.6-0.3-0.7-0.30.2-0.31.21.20.51.1
Delta time in closed arm before/after self-admin1.31.21.80.90.91.11.30.91.20.81.20.91.11.31.2
Delta time in open arm before/after self-admin4.34.28.4-2.1-2.3-2.4-2.5-2.3-2.5-2.9-2.4-0.9-0.6-0.6-1.3
Diff in mean of infusions in LGA sessions1.01.32.50.60.71.01.11.11.10.91.31.61.30.71.5
Delay discount exponential model param1.61.83.1-1.7-1.7-1.7-1.8-1.4-1.5-1.6-1.70.40.2-0.1-0.2
Extinction: sum of active levers before priming0.40.42.3-0.1-0.1-0.10.5-0.2-0.1-0.50.40.60.81.50.9
Active lever presses in extinction session 60.20.20.9-0.2-0.1-0.2-0.1-0.20.00.20.10.40.71.00.7
Bone: final force0.30.62.2-0.4-0.4-0.3-0.2-0.1-0.1-0.10.11.51.21.01.3
Bone: final moment0.50.93.2-0.6-0.6-0.4-0.4-0.2-0.2-0.30.11.81.51.31.5
Food consumed during 24 hour testing period1.11.54.3-0.8-0.8-0.6-0.6-0.4-0.3-0.50.02.02.11.81.8
Glucose1.32.13.82.01.91.81.31.91.81.51.7-0.4-0.4-0.00.2
Heart weight2.23.35.3-1.9-1.9-1.9-2.3-1.5-1.4-1.6-0.92.12.31.91.8
Delay discount hyperbolic model param1.51.62.7-1.5-1.6-1.6-1.6-1.4-1.5-1.6-1.60.30.1-0.2-0.2
Intermittent access intake day 1-15 change0.40.82.80.10.0-0.0-0.0-0.1-0.2-0.1-0.7-1.7-1.5-1.6-1.4
Intermittent access intake escalation0.40.93.10.10.1-0.00.0-0.1-0.2-0.2-0.7-1.8-1.5-1.7-1.4
Intermittent access intake escalation 20.91.02.11.01.00.90.71.10.80.90.4-1.4-1.1-1.5-0.9
Intermitt. access day 1 inactive lever presses0.10.51.6-0.2-0.4-0.20.0-0.2-0.3-0.90.11.11.31.21.0
Intermitt. access day 15 inactive lever presses0.40.82.20.20.20.40.80.40.40.00.61.41.41.51.4
Intermitt. access escalation Index0.10.20.70.30.50.40.40.40.40.40.3-0.6-0.8-0.0-0.5
Intermittent access day 1 total infusions0.40.61.2-1.0-0.8-0.8-0.7-0.7-0.7-0.8-0.61.10.70.80.4
Intermittent access day 15 total infusions0.40.61.3-0.7-0.6-0.6-0.6-0.6-0.8-0.5-1.1-0.7-0.9-0.9-1.0
Intermittent access terminal intake (last 3 days)0.20.30.9-0.7-0.6-0.5-0.4-0.5-0.6-0.4-0.9-0.2-0.3-0.4-0.6
Intermittent access total infusions0.50.61.3-1.0-0.9-0.9-0.9-0.9-1.0-0.8-1.20.0-0.3-0.1-0.5
Intermittent access day 1 locomotion0.30.30.6-0.7-0.5-0.5-0.6-0.6-0.7-0.7-0.8-0.1-0.5-0.1-0.7
Intermittent access day 15 total locomotion1.12.03.9-1.7-1.6-1.6-1.4-1.7-1.8-1.7-2.0-0.3-0.4-0.1-1.0
Intermittent access total locomotion2.32.86.0-1.9-1.9-1.9-1.5-2.0-2.0-2.4-2.4-0.3-0.20.1-0.9
Intermittent access standard deviation0.10.21.1-0.5-0.6-0.5-0.3-0.4-0.5-0.7-1.00.00.30.1-0.0
Left kidney weight9.041.765.1-8.1-8.0-7.6-6.1-7.7-7.0-7.0-5.85.05.24.63.5
Right kidney weight9.141.257.8-7.6-7.5-7.1-5.5-7.0-6.4-6.8-4.86.46.45.94.8
Cocaine induced anxiety0.50.81.5-0.7-0.8-0.7-0.6-0.6-0.6-1.2-0.41.21.11.11.0
Post-drug Anxiety0.20.20.30.60.40.40.30.50.5-0.10.30.30.40.60.6
Baseline Anxiety1.31.53.11.31.31.21.11.01.11.80.7-1.3-1.3-1.1-1.0
Tail length0.20.71.90.60.50.40.10.40.21.20.2-1.2-1.4-1.1-1.0
Length with tail0.10.30.5-0.6-0.7-0.7-0.6-0.6-0.70.1-0.40.40.30.30.4
Length without tail0.72.26.8-0.7-0.7-0.50.2-0.4-0.3-0.70.32.62.52.42.4
Times rat made contact with spout0.50.62.2-0.3-0.3-0.2-0.4-0.1-0.10.10.31.51.50.81.3
Lifetime Intake0.70.81.5-1.2-1.1-1.1-1.1-1.0-1.1-1.1-1.20.3-0.00.1-0.3
Liver weight, left0.20.30.7-0.7-0.7-0.6-0.0-0.9-0.7-0.6-0.7-0.00.20.20.1
Liver weight, right0.00.10.2-0.2-0.3-0.3-0.4-0.4-0.20.0-0.2-0.20.20.00.1
Locomotor activity1.01.53.4-1.6-1.6-1.6-1.8-1.4-1.3-1.0-1.20.60.60.50.4
Locomotor testing distance0.10.10.40.10.20.2-0.20.40.30.60.0-0.6-0.4-0.4-0.4
Locomotor testing rearing0.20.41.1-0.7-0.7-0.8-1.0-0.7-0.5-0.4-0.8-0.50.20.5-0.3
Locomotion in novel chamber2.32.96.7-1.1-1.0-1.2-1.5-1.4-1.4-0.8-1.7-2.2-2.4-2.1-2.6
Locomotion in novel chamber post-restriction0.50.82.20.70.80.60.30.50.60.60.3-1.5-1.4-1.4-1.1
Fecal boli incidents, locomotor time 10.10.21.0-0.2-0.2-0.10.3-0.4-0.1-1.0-0.00.30.60.70.5
Change in fecal boli incidents, locomotor task0.70.71.8-0.6-0.6-0.8-1.3-0.6-0.8-0.1-0.7-0.7-0.7-1.3-0.7
Time >=10cm from walls, locomotor time 10.50.53.3-0.7-0.7-0.6-0.4-0.4-0.5-1.8-0.50.10.30.30.1
Bouts of movement, locomotor time 10.20.30.50.60.50.50.70.40.50.30.70.40.40.50.4
Total resting periods, locomotor time 10.50.51.00.80.70.81.00.60.80.60.90.40.50.60.6
Rest time, locomotor task time 10.20.20.6-0.3-0.5-0.40.2-0.7-0.40.5-0.30.30.7-0.00.5
Distance moved, locomotor task time 10.00.10.2-0.2-0.00.1-0.30.30.2-0.4-0.10.30.00.30.1
Vertical activity count, locomotor time 10.10.20.60.10.40.5-0.00.80.60.10.50.40.10.10.2
Time >=10cm from walls, locomotor time 20.30.41.1-0.2-0.2-0.2-0.1-0.2-0.3-0.8-0.4-1.0-0.9-1.1-1.0
Bouts of movement, locomotor time 20.60.91.91.41.21.11.21.01.2-0.21.2-0.30.00.60.2
Total resting periods, locomotor time 20.71.22.51.61.41.31.51.21.40.11.4-0.20.20.80.4
Rest time, locomotor task time 20.30.31.60.60.50.50.60.30.41.30.6-0.3-0.0-0.8-0.0
Distance moved, locomotor task time 21.01.22.1-1.4-1.3-1.3-1.3-1.2-1.2-1.5-1.20.1-0.00.3-0.2
Vertical activity count, locomotor time 21.01.32.7-1.5-1.4-1.3-1.3-1.2-1.3-1.6-1.50.0-0.00.0-0.3
Light reinforcement 11.33.25.8-2.3-2.3-2.2-2.1-2.1-2.4-1.5-2.2-0.3-0.6-0.8-0.8
Light reinforcement 22.13.35.8-2.3-2.2-2.2-1.7-2.4-2.4-1.6-2.2-0.4-0.8-0.7-1.0
Bone: marrow area3.06.511.2-3.2-3.3-3.4-3.3-3.2-3.2-2.4-3.00.60.2-0.0-0.2
Bone: maximum diameter3.26.010.7-2.9-3.1-3.2-3.3-3.1-3.0-2.5-2.70.70.30.40.1
Bone: maximum force0.51.02.1-0.9-0.9-0.8-0.9-0.7-0.6-0.5-0.41.41.41.11.4
Bone: maximum moment0.81.43.2-1.1-1.1-1.0-1.1-0.8-0.7-0.7-0.51.81.71.51.6
Mean time between licks in bursts0.92.23.61.71.61.30.41.31.21.80.9-1.8-1.9-1.7-1.3
Mean num. licks in bursts1.01.65.7-0.9-0.9-0.6-0.2-0.6-0.4-0.60.02.42.11.62.0
Cd content in liver0.30.31.4-0.6-0.6-0.6-1.2-0.4-0.5-0.1-0.40.50.30.10.2
Co content in liver0.20.30.6-0.8-0.8-0.6-0.8-0.3-0.8-0.2-0.60.00.1-0.2-0.1
Cu content in liver2.63.18.01.31.31.31.40.90.91.60.2-2.5-2.6-2.8-2.2
Fe content in liver0.50.61.6-0.9-0.8-0.8-1.3-0.5-0.6-0.6-0.41.10.70.60.6
K content in liver0.30.31.1-0.7-0.6-0.21.0-0.6-0.5-0.7-0.50.30.60.20.2
Mg content in liver0.20.21.7-0.10.00.31.3-0.00.1-0.3-0.00.10.40.20.1
Mn content in liver0.80.81.7-1.3-1.2-1.1-0.3-1.3-1.2-1.0-1.20.30.4-0.0-0.2
Na content in liver1.31.42.31.51.51.41.21.31.51.21.1-0.9-0.8-0.7-0.5
Rb content in liver0.20.20.50.30.30.40.20.50.40.30.60.50.60.70.6
Se content in liver0.10.20.8-0.1-0.00.10.4-0.1-0.20.2-0.2-0.5-0.6-0.9-0.5
Sr content in liver0.50.51.40.80.80.91.20.70.70.60.6-0.4-0.4-0.4-0.3
Zn content in liver0.40.51.0-1.0-0.9-0.7-0.2-0.9-0.9-0.9-0.90.10.30.20.1
Bone: minimum diameter1.83.35.3-1.8-1.9-2.1-2.2-2.1-2.2-1.3-2.3-1.0-1.4-1.6-1.5
Time in familiar zone, hab. session 10.50.50.9-0.9-0.9-0.9-0.7-0.9-0.9-0.6-0.70.40.60.30.2
Time in novel zone, hab. session 10.20.20.70.30.20.1-0.80.40.2-0.00.1-0.7-0.5-0.2-0.4
Total zone transitions, hab. session 11.01.32.41.51.51.51.51.41.40.81.2-0.9-0.3-0.2-0.3
Total locomotion distance, hab. session 10.40.51.1-0.7-0.7-0.6-0.1-0.9-0.8-1.0-1.0-0.8-0.3-0.3-0.8
Locomotion velocity, hab. session 10.40.51.2-0.8-0.8-0.60.1-1.0-0.9-1.0-1.1-0.5-0.2-0.2-0.7
Time in familiar zone, hab. session 20.30.30.6-0.4-0.5-0.5-0.2-0.6-0.6-0.7-0.8-0.6-0.3-0.2-0.7
Time in novel zone, hab. session 20.20.20.50.30.40.3-0.40.70.50.50.70.50.30.30.5
Total zone transitions, hab. session 20.60.82.9-0.3-0.3-0.00.7-0.2-0.1-0.70.21.41.51.71.1
Total locomotion distance, hab. session 20.30.41.3-0.7-0.8-0.60.1-0.8-0.7-1.1-0.70.20.50.70.0
Locomotion velocity, hab. session 20.20.30.8-0.5-0.5-0.30.5-0.6-0.5-0.9-0.50.20.50.70.1
Novel to familiar place preference ratio0.30.41.9-0.5-0.6-0.7-1.4-0.5-0.5-0.5-0.40.10.20.30.1
Novelty place preference0.60.72.9-0.8-0.9-1.1-1.7-0.8-0.8-0.7-0.70.20.20.40.1
Time in novel zone, NPP test0.80.94.2-1.0-1.0-1.2-2.0-0.8-0.9-0.9-0.80.20.30.40.1
Total zone transitions, NPP test0.30.41.00.50.50.71.00.60.60.20.70.40.80.80.6
Total locomotion distance, NPP test0.50.71.4-1.0-1.0-0.9-0.3-1.1-1.1-1.1-1.2-0.20.10.2-0.4
Locomotion velocity, NPP test0.30.40.9-0.6-0.6-0.50.3-0.8-0.8-0.7-0.9-0.5-0.3-0.3-0.7
Intraocular pressure0.10.10.5-0.1-0.0-0.2-0.7-0.00.10.2-0.3-0.4-0.30.2-0.2
Delta distance traveled before/after self-admin1.41.52.8-1.5-1.7-1.5-1.6-1.6-1.7-0.9-1.30.30.30.00.0
Delta ambulatory time before/after self-admin0.91.12.3-1.3-1.4-1.3-1.5-1.4-1.3-0.9-1.20.40.40.30.2
Parametrial fat weight0.41.02.80.70.80.70.60.50.40.80.2-1.3-1.7-1.6-1.1
Pavlov. Cond. lever latency0.50.61.5-0.8-0.9-0.9-1.2-0.7-0.7-0.8-0.60.50.50.70.7
Pavlov. Cond. magazine entry latency2.43.05.22.32.32.32.12.22.11.81.9-0.2-0.1-0.5-0.1
Pavlov. Cond. change in total contacts2.52.74.62.12.12.12.02.11.91.71.8-0.2-0.3-0.5-0.1
Pavlov. Cond. index score2.02.54.32.12.02.12.02.01.91.61.8-0.10.0-0.3-0.0
Pavlov. Cond. latency score1.21.52.71.61.61.61.61.61.51.31.3-0.2-0.1-0.4-0.2
Pavlov. Cond. lever contacts1.31.63.21.51.51.51.81.31.21.31.0-0.8-0.8-1.1-0.9
Pavlov. Cond. magazine entry number3.54.47.5-2.7-2.7-2.7-2.4-2.7-2.6-2.2-2.40.30.10.50.0
Pavlov. Cond. intertrial magazine entries0.10.10.20.20.20.30.40.30.20.20.20.2-0.4-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.2.22.74.62.12.12.22.12.12.01.61.8-0.2-0.2-0.5-0.2
Pavlov. Cond. response bias2.93.66.02.42.42.42.42.32.22.01.9-0.6-0.5-0.9-0.5
Pavlov. Cond. lever latency0.20.30.90.40.40.1-0.80.30.30.50.1-0.9-0.8-0.5-0.6
Pavlov. Cond. magazine entry latency0.91.04.50.91.01.22.10.91.00.31.10.60.70.70.6
Pavlov. Cond. change in total contacts0.61.03.0-0.00.00.51.30.30.3-0.10.61.71.51.31.5
Pavlov. Cond. index score0.40.52.80.40.40.71.70.40.50.10.60.80.80.50.7
Pavlov. Cond. latency score0.40.53.00.40.40.71.70.40.40.00.60.80.70.50.6
Pavlov. Cond. lever contacts0.20.31.1-0.2-0.10.21.0-0.1-0.0-0.30.21.00.90.60.7
Pavlov. Cond. magazine entry number0.40.63.1-0.4-0.4-0.7-1.8-0.4-0.40.2-0.6-0.7-0.7-0.7-0.6
Pavlov. Cond. intertrial magazine entries0.30.41.2-0.1-0.1-0.2-0.80.10.20.10.20.91.11.01.1
Pavlov. Cond. lever-magazine prob. diff.0.30.42.50.20.30.61.60.20.3-0.10.40.60.60.40.5
Pavlov. Cond. response bias0.50.72.60.40.50.81.60.60.60.10.81.01.00.81.0
Time in closed arm before self-admin1.62.04.11.61.41.31.01.21.01.00.6-1.8-2.0-1.9-1.6
Time in closed arm after self-admin1.01.11.81.21.11.20.91.11.01.30.8-0.7-1.2-1.0-0.7
Time in open arm before self-admin0.10.20.80.30.40.40.50.20.50.90.3-0.10.20.20.2
Time in open arm after self-admin3.03.37.4-2.0-2.1-2.2-1.7-2.3-2.1-2.7-2.2-0.40.30.3-0.6
Bone: periosteal estimation2.14.57.9-2.5-2.7-2.8-2.8-2.6-2.6-2.1-2.50.3-0.0-0.1-0.3
Bone: periosteal perimeter2.84.710.2-2.3-2.5-2.8-3.2-2.6-2.6-1.9-2.7-0.7-1.0-0.8-1.2
Bone: post-yield work1.31.93.61.11.11.10.71.41.50.91.61.51.71.41.9
Progressive ratio test 1 active lever presses0.00.00.2-0.2-0.0-0.1-0.3-0.20.1-0.1-0.40.1-0.10.1-0.2
Progressive ratio test 1 breakpoint0.00.00.1-0.00.20.1-0.10.00.30.2-0.20.1-0.20.0-0.2
Progressive ratio test 1 inactive lever presses0.30.40.7-0.6-0.7-0.7-0.6-0.9-0.6-0.8-0.70.30.40.80.1
Progressive ratio test 2 active lever presses0.70.92.6-0.9-0.7-0.6-0.1-0.5-0.4-0.8-0.51.31.31.61.0
Progressive ratio test 2 breakpoint0.60.72.0-0.9-0.7-0.6-0.2-0.6-0.5-0.8-0.61.11.21.40.9
Progressive ratio test 2 inactive lever presses0.10.10.5-0.1-0.10.00.5-0.1-0.10.0-0.10.60.60.70.5
Incentive Sensitization - Responses1.21.75.6-1.1-1.0-0.7-0.1-0.7-0.6-1.3-0.31.71.92.41.6
Incentive Sensitization - Breakpoint1.41.85.8-1.2-1.1-0.8-0.1-0.8-0.7-1.4-0.41.82.02.41.6
Sum of active levers in priming session hrs 5-60.50.51.1-0.8-0.8-0.8-0.6-0.9-0.9-1.0-0.8-0.10.1-0.0-0.2
Progressive ratio0.91.42.91.41.51.51.31.61.50.71.70.40.50.40.7
Food seeking constrained by brief footshock0.30.30.7-0.8-0.7-0.5-0.5-0.3-0.5-0.2-0.60.90.70.10.6
Seeking ratio, punishment vs. effort0.40.61.2-1.1-1.1-0.9-0.7-0.9-1.0-0.2-1.10.50.30.10.3
Retroperitoneal fat weight0.73.04.4-1.9-1.9-1.8-1.1-1.9-1.6-1.6-1.22.12.11.61.8
Reaction time number correct0.40.71.60.90.90.70.80.60.60.50.5-1.3-1.2-0.6-1.0
Reaction time mean minus median0.10.10.20.30.40.3-0.10.40.50.40.50.20.50.30.3
Reaction time mean minus median AUC0.10.20.5-0.3-0.3-0.4-0.6-0.4-0.1-0.3-0.20.10.70.60.3
Reaction time num false alarms0.30.41.10.50.30.2-0.80.40.30.60.1-1.0-0.9-1.0-0.8
Reaction time num false alarms AUC0.10.20.50.30.20.1-0.70.30.20.30.2-0.7-0.5-0.6-0.5
Reaction time trials correct on left0.40.71.60.90.90.70.80.60.60.50.5-1.3-1.2-0.6-1.0
Reaction time trials on left0.40.81.61.00.90.80.90.60.70.60.5-1.3-1.2-0.5-1.0
Reaction time mean0.50.71.71.01.11.10.81.01.30.91.0-0.10.20.40.2
Reaction time mean AUC0.50.81.71.01.21.10.81.01.30.81.0-0.10.20.40.2
Median of all reaction times0.71.02.21.21.31.31.01.21.51.01.2-0.10.10.40.2
Reaction time omissions0.50.81.51.11.11.00.71.01.21.21.1-0.10.30.40.2
Reaction time false alarm rate0.10.10.9-0.1-0.2-0.2-1.00.1-0.10.0-0.1-0.20.0-0.4-0.1
Reaction time premature initiation rate1.21.64.9-0.10.10.41.40.30.6-0.10.51.92.12.22.0
Reaction time premature initiations0.61.13.00.40.60.71.60.50.80.20.81.21.31.71.3
Std. dev. reaction times0.10.10.40.30.50.40.10.40.70.60.4-0.00.30.20.2
Reaction time trials completed0.40.81.61.00.90.80.90.60.70.60.5-1.3-1.2-0.5-1.0
Reaction time trials AUC0.30.51.40.70.70.60.70.40.40.30.3-1.2-1.1-0.4-1.0
Run reversals in cocaine runway, females1.61.65.90.10.20.1-0.00.1-0.20.3-0.6-2.0-2.0-2.4-2.1
Run reversals in cocaine runway, males0.70.72.1-0.8-1.0-1.1-1.4-0.8-1.0-0.8-0.90.10.2-0.4-0.0
Latency to leave start box in cocaine runway0.91.02.5-1.2-1.1-1.0-0.8-1.0-1.0-1.6-1.00.90.61.10.5
Latency to leave start box in cocaine runway, F0.40.51.2-0.7-0.6-0.5-0.2-0.4-0.4-1.1-0.31.10.90.90.8
Latency to leave start box in cocaine runway, M1.11.02.1-1.2-1.1-1.2-1.1-1.3-1.2-1.2-1.50.1-0.10.4-0.3
Std. dev. time between licks in bursts0.40.61.60.90.90.91.20.60.70.90.8-0.3-0.3-0.3-0.0
Total sessions with >9 infusions1.82.13.8-1.8-1.7-1.6-1.5-1.5-1.5-1.9-1.31.31.21.20.6
Short access day 1 total inactive lever presses1.82.35.8-1.4-1.4-1.2-1.0-1.0-1.0-1.0-0.32.42.22.01.8
Short access day 10 total inactive lever presses0.92.13.3-1.6-1.7-1.5-1.3-1.6-1.5-1.8-1.21.31.11.60.7
Short access day 1 total infusions0.60.91.5-1.1-1.0-0.9-1.1-0.7-0.9-1.0-0.41.21.00.70.7
Short access day 10 total infusions0.10.10.2-0.3-0.2-0.3-0.3-0.3-0.2-0.4-0.40.1-0.2-0.1-0.3
Short access total infusions0.81.01.5-1.2-1.1-1.1-1.1-1.0-1.0-1.2-0.81.00.80.80.5
Short access day 1 locomotion0.50.61.1-1.0-1.1-0.9-1.0-0.9-1.0-0.8-0.90.60.20.1-0.1
Short access day 10 total locomotion0.10.31.00.20.20.10.10.0-0.0-0.2-0.3-1.0-0.8-0.7-1.0
Short access total locomotion0.30.30.7-0.5-0.4-0.5-0.6-0.6-0.6-0.8-0.8-0.3-0.5-0.2-0.7
One hour access (0.3 mA shock)0.30.30.6-0.8-0.6-0.6-0.4-0.6-0.7-0.2-0.8-0.1-0.5-0.5-0.7
Compulsive drug intake1.51.84.10.60.70.91.11.01.00.81.82.01.81.22.0
One hour access (shock baseline)1.32.04.1-1.0-1.0-1.2-1.3-1.2-1.3-1.1-1.8-1.6-1.8-1.4-2.0
Social response proportion0.30.30.8-0.6-0.7-0.6-0.4-0.6-0.8-0.9-0.30.20.30.30.1
Social responses0.10.10.4-0.5-0.5-0.30.4-0.6-0.6-0.3-0.40.00.1-0.3-0.1
Social time2.22.95.32.32.12.22.32.12.01.32.3-0.3-0.10.20.1
Soleus weight0.30.82.7-0.2-0.10.00.30.10.40.00.31.51.71.21.7
Bone: stiffness0.30.50.80.80.70.6-0.10.90.80.90.80.60.60.30.8
Tibialis anterior weight0.00.10.40.00.10.10.6-0.1-0.00.1-0.1-0.4-0.1-0.2-0.2
Time to tail flick, vehicle, before self-admin0.20.20.8-0.1-0.2-0.10.00.1-0.20.30.30.80.9-0.10.7
Time to tail flick, vehicle, after self-admin0.20.20.7-0.1-0.2-0.3-0.3-0.2-0.3-0.4-0.6-0.8-0.4-0.7-0.6
Time to tail flick, test, before self-admin0.20.20.8-0.1-0.1-0.2-0.4-0.2-0.20.5-0.4-0.5-0.3-0.9-0.3
Time to tail flick, test, after self-admin0.20.20.40.60.60.60.50.50.50.30.2-0.7-0.3-0.1-0.4
Delta time to tail flick, vehicle, before/after SA0.50.51.5-0.6-0.5-0.4-0.4-0.4-0.2-1.1-0.60.61.01.20.7
Delta time to tail flick, test, before/after SA0.20.20.60.50.50.60.80.50.50.20.4-0.10.00.1-0.1
Tibia length0.10.30.8-0.5-0.6-0.6-0.9-0.4-0.4-0.1-0.10.70.70.50.7
Ambulatory time before self-admin0.10.20.30.60.50.60.50.50.50.10.60.20.20.20.3
Ambulatory time after self-admin0.00.00.10.1-0.10.1-0.1-0.0-0.10.1-0.0-0.1-0.2-0.30.0
Bone: tissue strength0.20.20.7-0.1-0.1-0.1-0.10.00.00.30.10.70.80.40.8
Total heroin consumption0.60.72.0-0.7-0.5-0.50.0-0.5-0.3-0.10.11.41.40.91.4
Bone: trabecular number0.40.71.70.70.60.6-0.20.80.50.90.3-1.0-1.3-1.1-0.8
Bone: trabecular spacing1.11.42.3-1.3-1.2-1.2-0.4-1.4-0.9-1.5-0.71.31.41.51.0
Bone: trabecular thickness0.10.10.30.10.10.30.50.20.00.1-0.1-0.5-0.6-0.4-0.4
Bone: trabecular tissue density0.40.51.60.80.81.01.30.90.80.20.8-0.00.20.60.2
Water consumed over 24 hours1.01.32.9-1.0-1.1-1.0-1.4-0.7-0.7-0.7-0.41.61.71.31.2
Number of responses in last shaping day0.50.51.00.80.81.01.01.00.90.90.70.30.2-0.10.2