Hub : Genes

Samd12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC intron excision ratio chr7_86856864_86947062 0.27 0.17 4.9e-03 0.1 0.06 -0 0.07 2.7e-03 1.9e-02 4.5e-01 9.0e-03
2 NAcc intron excision ratio chr7_86838504_86856724 0.08 0.05 2.1e-04 0.02 0.02 0.02 0.02 1.8e-04 2.0e-04 2.5e-04 3.2e-04
3 PL gene expression Samd12 0.03 0.02 5.6e-04 0.04 0.02 0.03 0.01 4.0e-05 2.9e-03 5.8e-04 1.2e-02
4 NAcc gene expression Samd12 0.07 0.05 6.7e-08 0.06 0.05 0.06 0.06 3.2e-09 1.2e-08 7.2e-09 3.0e-09
5 Adipose gene expression Samd12 0.13 0.1 6.5e-09 0.07 0.04 0.06 0.06 5.1e-08 7.2e-05 4.5e-07 2.5e-07
6 Brain gene expression Samd12 0.03 0.02 2.3e-03 0.02 0.02 0.01 0.02 5.3e-03 6.5e-03 1.8e-02 5.2e-03
7 pVTA gene expression Samd12 0.06 0.04 1.2e-05 0.07 0.06 0.06 0.06 2.3e-06 1.6e-05 2.9e-05 1.2e-05
8 LHb gene expression Samd12 0.15 0.11 2.6e-03 0.06 0.04 -0 0.04 1.6e-02 4.9e-02 3.6e-01 3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.11.93.01.3-1.31.11.2-1.01.51.71.7
Area under the delay curve0.20.20.5-0.70.70.10.7-0.20.40.10.4
BMI with tail1.45.017.44.2-4.1-0.8-2.10.40.2-0.10.7
BMI without tail1.13.211.33.4-3.2-0.9-1.50.40.50.10.9
Body weight1.98.424.24.9-4.9-1.8-3.51.4-0.7-1.1-0.7
Weight adjusted by age0.50.83.11.8-1.40.8-0.3-0.30.30.3-0.3
Bone surface0.20.30.60.8-0.80.10.30.00.50.50.6
Bone volume0.71.22.01.0-1.00.81.1-0.61.11.41.4
Breakpoint value in progressive ratio session2.02.44.0-1.51.4-1.0-1.21.4-1.9-1.8-2.0
Number of licking bursts0.10.20.4-0.20.2-0.6-0.60.4-0.3-0.5-0.4
Context. condit. distance diff. score0.91.02.41.2-1.2-1.6-1.11.1-0.6-0.4-0.5
Locomotion velocity, session 10.10.10.20.1-0.10.1-0.3-0.20.4-0.40.5
Locomotion distance, session 10.00.00.10.2-0.1-0.2-0.10.1-0.1-0.10.1
Locomotion velocity, session 23.74.36.7-0.80.82.62.6-2.62.02.12.2
Locomotion distance, session 20.40.51.2-0.10.10.81.1-0.50.81.00.7
Locomotion velocity, session 31.11.22.11.5-1.4-1.0-1.31.4-0.6-0.7-0.5
Locomotion distance, session 31.81.94.90.9-0.8-1.9-1.42.2-1.2-1.0-1.1
Stereotopy head waving bouts, day 30.10.10.30.5-0.50.1-0.4-0.0-0.2-0.2-0.1
Stereotopy head waving duration, day 30.91.12.10.9-0.91.50.6-1.30.90.91.1
Locomotion velocity, session 70.40.41.41.2-1.2-0.2-0.10.20.30.60.2
Locomotion distance, session 71.62.04.01.5-1.5-2.0-1.31.9-1.1-0.6-1.0
Stereotopy head waving bouts, day 74.45.07.70.6-0.62.82.5-2.42.62.62.5
Stereotopy head waving duration, day 73.54.27.00.3-0.32.62.3-2.42.42.22.2
Locomotion velocity, session 80.00.00.10.3-0.3-0.2-0.30.1-0.2-0.2-0.2
Locomotion distance, session 80.91.23.01.2-1.2-1.7-0.81.6-0.7-0.1-0.7
Degree of sensitization distance0.00.00.10.3-0.3-0.1-0.1-0.3-0.00.1-0.0
Degree of sensitization stereotypy5.55.99.0-0.10.13.03.0-2.72.82.82.6
Conditioned locomotion0.20.20.50.0-0.1-0.4-0.50.4-0.4-0.7-0.6
Cocaine response after cond. corrected0.40.51.4-1.21.20.70.5-0.6-0.30.2-0.1
Cocaine response after cond. not corrected0.40.40.7-0.80.80.70.8-0.60.10.70.1
Cocaine response before conditioning0.40.41.01.0-1.0-0.40.30.40.50.80.3
Saline control response1.72.25.2-0.50.5-2.1-1.22.3-1.4-1.4-1.7
Bone: connectivity density0.30.50.80.2-0.20.70.8-0.60.80.80.9
Bone: cortical apparent density0.70.91.3-0.80.81.11.1-1.01.00.81.1
Bone: cortical area1.62.48.42.9-2.9-1.0-0.71.10.10.20.0
Bone: cortical porosity0.50.61.51.2-1.2-0.30.50.40.50.80.4
Bone: cortical porosity0.80.92.81.7-1.7-0.60.10.50.30.70.3
Bone: cortical thickness0.71.23.71.9-1.90.00.30.10.90.80.8
Bone: cortical thickness1.21.43.21.8-1.80.60.8-0.60.91.31.0
Bone: cortical tissue density0.81.11.5-0.90.91.21.2-1.11.00.81.1
Condit. Reinf. active minus inactive responses0.30.30.6-0.80.8-0.3-0.30.5-0.5-0.6-0.4
Condit. Reinf. active-inactive response ratio1.21.32.1-1.41.41.51.2-1.10.90.30.8
Condit. Reinf. active responses0.70.81.70.1-0.1-1.3-1.11.2-0.8-1.0-0.9
Condit. Reinf. inactive responses2.22.75.51.5-1.4-2.3-1.91.9-1.3-1.2-1.3
Incentive salience index mean0.40.51.1-0.30.3-0.9-0.71.1-0.7-0.8-0.6
Condit. Reinf. lever presses0.30.41.20.4-0.4-1.0-0.61.1-0.5-0.3-0.5
Condit. Reinf. active minus inactive responses0.50.72.11.4-1.4-0.2-1.00.4-0.0-0.3-0.1
Condit. Reinf. active-inactive response ratio0.70.82.11.5-1.4-0.2-1.10.4-0.4-0.5-0.3
Condit. Reinf. active responses1.21.65.42.3-2.3-0.5-1.30.60.1-0.20.1
Condit. Reinf. inactive responses0.30.41.31.1-1.1-0.4-0.20.40.30.50.4
Condit. Reinf. lever presses0.81.12.41.0-1.00.50.9-0.31.41.51.1
Condit. Reinf. lever reinforcers received1.11.55.12.3-2.2-0.5-1.00.60.30.10.2
Conditioned reinforcement - actives0.20.30.80.8-0.90.5-0.5-0.10.2-0.10.2
Conditioned reinforcement - inactives0.20.41.01.0-0.9-0.5-0.60.5-0.2-0.2-0.1
Conditioned locomotion1.21.63.81.0-1.0-0.8-2.01.1-1.3-1.5-1.2
Patch foraging indifference point 0 sec0.50.81.60.5-0.5-1.3-1.31.2-0.9-0.7-0.6
Patch foraging indifference point AUC1.92.75.71.1-0.9-2.4-1.82.2-1.2-1.5-1.5
Delay disc. indifference point, 0s delay0.30.30.7-0.60.8-0.1-0.4-0.0-0.5-0.9-0.5
Delay disc. indifference point, 16s delay0.80.91.7-0.70.50.91.3-1.01.10.71.1
Delay disc. indifference point, 2s delay0.91.01.7-0.70.50.81.3-0.91.01.21.1
Delay disc. indifference point, 24s delay0.20.20.6-0.40.4-0.70.10.8-0.5-0.2-0.5
Delay disc. indifference point, 4s delay0.00.00.20.00.00.00.40.10.20.20.1
Delay disc. indifference point, 8s delay0.70.81.7-0.60.7-1.3-0.60.9-1.0-1.2-0.7
Indifference point function ln k0.50.92.8-0.60.51.70.7-1.40.60.60.9
Indifference point function log k0.50.92.8-0.60.51.70.7-1.40.60.60.9
Patch foraging total patch changes 0 sec0.30.51.10.3-0.4-1.1-1.00.9-0.8-0.5-0.5
Patch foraging total patch changes 12 sec2.02.66.4-0.30.3-2.3-1.42.5-1.6-1.3-1.6
Patch foraging total patch changes 18 sec1.11.74.12.0-1.9-1.5-1.01.6-0.2-0.3-0.2
Patch foraging total patch changes 24 sec0.10.20.5-0.70.7-0.40.00.3-0.4-0.3-0.2
Patch foraging total patch changes 6 sec2.03.04.9-0.70.7-2.0-1.72.2-2.1-1.6-2.1
Patch foraging time to switch 0 sec0.51.02.8-1.71.61.10.8-0.7-0.2-0.1-0.1
Patch foraging water rate 0 sec0.40.92.91.7-1.7-0.5-0.7-0.00.40.40.3
Patch foraging water rate 12 sec0.30.61.61.3-1.20.00.1-0.60.50.80.8
Patch foraging water rate 18 sec0.10.10.20.3-0.5-0.4-0.50.4-0.3-0.2-0.3
Patch foraging water rate 24 sec0.10.20.50.1-0.1-0.1-0.60.0-0.7-0.6-0.4
Patch foraging water rate 6 sec1.42.16.12.5-2.4-0.00.1-0.41.21.21.3
Seeking ratio, delayed vs. immediate footshock0.00.00.10.3-0.10.3-0.1-0.2-0.20.0-0.3
Distance traveled before self-admin0.30.41.10.4-0.5-1.1-0.80.9-0.3-0.3-0.5
Distance traveled after self-admin0.00.00.1-0.30.10.2-0.2-0.3-0.0-0.10.2
Extensor digitorum longus weight2.18.128.65.3-5.3-1.9-1.91.00.20.3-0.0
Bone: elastic displacement4.34.97.11.0-1.02.42.4-2.42.72.42.6
Bone: elastic work2.53.34.71.7-1.71.61.6-1.62.11.92.2
Bone: endosteal estimation1.83.96.01.1-1.1-2.5-2.22.3-2.2-1.6-2.1
Bone: endosteal perimeter1.32.73.82.0-1.9-1.9-1.91.8-1.1-1.0-1.2
Epididymis fat weight2.06.79.9-0.70.6-2.5-3.02.9-3.0-3.1-3.1
Delta time in closed arm before/after self-admin0.50.40.9-0.70.90.51.0-0.40.60.60.3
Delta time in open arm before/after self-admin0.10.10.50.0-0.20.5-0.1-0.7-0.0-0.3-0.0
Diff in mean of infusions in LGA sessions0.20.20.5-0.70.70.60.4-0.3-0.0-0.1-0.3
Delay discount exponential model param0.20.20.60.8-0.80.0-0.70.1-0.3-0.1-0.3
Extinction: sum of active levers before priming0.60.72.3-1.41.50.00.70.3-0.2-0.2-0.6
Active lever presses in extinction session 60.10.10.4-0.10.20.30.60.20.40.60.3
Bone: final force0.91.52.71.2-1.2-1.5-1.31.6-0.9-0.8-1.1
Bone: final moment0.60.91.61.0-1.0-1.2-1.01.3-0.7-0.6-0.8
Food consumed during 24 hour testing period1.92.74.0-1.51.5-1.0-1.51.5-1.9-1.9-2.0
Glucose0.91.44.2-2.12.0-0.3-0.20.5-1.1-0.8-0.9
Heart weight0.91.42.31.0-1.21.00.8-1.11.51.41.4
Delay discount hyperbolic model param0.30.30.80.6-0.6-0.3-0.90.3-0.5-0.4-0.6
Intermittent access intake day 1-15 change1.53.27.9-0.50.62.82.1-2.11.91.51.6
Intermittent access intake escalation2.04.29.3-0.50.63.02.4-2.32.31.92.0
Intermittent access intake escalation 24.85.49.20.7-0.53.02.5-2.52.82.52.7
Intermitt. access day 1 inactive lever presses0.62.13.70.6-0.4-1.7-1.21.9-1.7-1.6-1.7
Intermitt. access day 15 inactive lever presses0.10.20.50.4-0.20.1-0.5-0.10.7-0.30.6
Intermitt. access escalation Index1.01.53.5-1.81.9-0.1-0.20.1-1.2-1.6-1.0
Intermittent access day 1 total infusions0.30.41.1-0.91.00.2-0.40.1-0.5-0.8-0.5
Intermittent access day 15 total infusions1.72.56.1-1.11.22.51.7-2.11.31.01.2
Intermittent access terminal intake (last 3 days)1.01.33.5-0.50.61.91.2-1.41.10.71.0
Intermittent access total infusions0.30.41.3-0.30.41.10.5-0.80.40.10.4
Intermittent access day 1 locomotion0.40.51.6-0.40.40.1-1.1-0.1-0.7-1.3-0.5
Intermittent access day 15 total locomotion0.20.41.00.4-0.30.9-1.0-0.5-0.1-0.8-0.1
Intermittent access total locomotion0.30.40.70.8-0.70.7-0.9-0.40.2-0.60.2
Intermittent access standard deviation0.10.30.90.9-0.80.60.1-0.30.20.20.0
Left kidney weight0.52.35.5-0.10.1-0.8-2.20.6-1.9-2.3-1.7
Right kidney weight0.41.84.60.9-1.1-0.8-2.10.6-1.5-1.6-1.3
Cocaine induced anxiety0.30.41.1-0.50.51.00.5-0.80.30.30.3
Post-drug Anxiety1.11.21.90.6-0.50.91.1-1.01.41.31.4
Baseline Anxiety0.40.51.21.1-0.9-0.20.5-0.10.80.70.8
Tail length0.41.64.92.2-2.2-0.00.2-0.21.21.01.0
Length with tail0.72.97.92.7-2.8-1.1-2.01.0-0.5-0.8-1.0
Length without tail1.03.16.52.3-2.5-1.1-2.51.0-1.2-1.4-1.4
Times rat made contact with spout2.52.84.2-1.91.9-1.4-1.02.1-1.5-1.4-1.9
Lifetime Intake0.20.20.9-0.40.40.90.3-0.50.30.00.2
Liver weight, left0.30.41.60.1-0.2-0.2-1.20.1-0.6-1.3-0.3
Liver weight, right0.30.51.31.0-1.0-0.3-1.10.2-0.1-0.80.1
Locomotor activity1.01.55.62.4-2.2-0.7-0.90.60.3-0.20.4
Locomotor testing distance0.30.61.81.3-1.2-0.5-0.80.5-0.1-0.70.1
Locomotor testing rearing0.40.81.50.3-0.4-1.1-1.11.1-1.0-1.2-0.4
Locomotion in novel chamber0.40.61.71.3-1.00.1-0.1-0.30.70.41.1
Locomotion in novel chamber post-restriction0.10.20.9-0.00.3-0.4-0.10.9-0.4-0.3-0.2
Fecal boli incidents, locomotor time 10.00.10.1-0.00.4-0.30.3-0.3-0.30.2-0.2
Change in fecal boli incidents, locomotor task0.20.20.40.2-0.30.20.50.20.60.6-0.2
Time >=10cm from walls, locomotor time 10.90.91.81.0-0.8-1.1-1.30.8-0.9-0.8-0.8
Bouts of movement, locomotor time 10.50.50.9-0.1-0.30.70.8-0.90.90.70.9
Total resting periods, locomotor time 10.91.01.4-0.2-0.11.11.2-1.21.21.11.2
Rest time, locomotor task time 10.70.83.1-1.81.50.41.0-0.00.20.30.0
Distance moved, locomotor task time 11.11.62.51.5-1.61.10.5-1.31.11.31.5
Vertical activity count, locomotor time 10.10.41.31.1-1.00.4-0.3-0.30.00.10.5
Time >=10cm from walls, locomotor time 21.72.53.80.3-0.2-1.9-1.91.6-2.0-1.7-1.8
Bouts of movement, locomotor time 20.10.10.3-0.60.5-0.20.1-0.0-0.3-0.4-0.2
Total resting periods, locomotor time 20.10.20.6-0.70.7-0.20.00.1-0.4-0.6-0.4
Rest time, locomotor task time 20.50.62.7-1.61.30.30.70.3-0.00.2-0.2
Distance moved, locomotor task time 21.51.84.42.1-2.00.80.4-1.21.01.11.2
Vertical activity count, locomotor time 20.71.03.01.7-1.5-0.6-1.20.0-0.7-0.6-0.3
Light reinforcement 10.10.30.7-0.70.9-0.2-0.40.5-0.6-0.7-0.4
Light reinforcement 20.81.21.8-1.31.4-0.9-0.81.1-1.0-1.3-0.9
Bone: marrow area1.84.06.11.1-1.1-2.5-2.32.3-2.2-1.7-2.2
Bone: maximum diameter1.83.44.81.9-1.9-2.2-2.02.2-1.4-1.3-1.6
Bone: maximum force1.62.84.42.1-2.1-2.0-1.62.0-1.0-0.9-1.1
Bone: maximum moment1.12.03.81.9-1.9-1.6-1.31.6-0.8-0.7-0.8
Mean time between licks in bursts0.71.82.61.0-1.01.41.1-1.31.61.51.6
Mean num. licks in bursts0.10.20.5-0.70.70.10.30.5-0.30.1-0.5
Cd content in liver2.83.14.50.5-0.51.82.0-2.12.12.02.1
Co content in liver1.11.22.21.5-1.50.51.0-0.51.01.51.0
Cu content in liver1.21.44.9-2.22.20.5-0.1-0.7-0.3-0.60.1
Fe content in liver1.31.62.8-0.80.8-1.0-1.51.1-1.5-1.7-1.4
K content in liver6.26.08.4-1.71.7-2.4-2.52.3-2.9-2.9-2.9
Mg content in liver2.12.23.1-1.41.4-1.6-1.11.3-1.8-1.5-1.6
Mn content in liver0.40.41.0-0.60.7-0.5-0.80.4-0.6-1.0-0.3
Na content in liver4.85.16.8-2.42.4-1.5-2.01.8-2.6-2.6-2.5
Rb content in liver0.81.02.5-1.61.6-0.0-0.5-0.2-1.0-0.9-0.8
Se content in liver0.20.20.4-0.70.6-0.3-0.50.4-0.2-0.40.0
Sr content in liver0.50.41.31.1-1.1-0.6-0.50.3-0.00.0-0.1
Zn content in liver3.13.55.2-0.40.4-2.2-2.31.9-2.1-2.1-2.2
Bone: minimum diameter3.15.68.93.0-3.0-2.6-2.52.5-1.7-1.5-1.5
Time in familiar zone, hab. session 10.10.10.20.3-0.3-0.40.10.3-0.30.4-0.4
Time in novel zone, hab. session 10.40.41.1-1.01.00.3-0.20.1-0.3-0.9-0.4
Total zone transitions, hab. session 11.11.63.92.0-1.90.50.8-0.61.21.21.0
Total locomotion distance, hab. session 10.71.02.71.6-1.6-0.8-1.00.5-0.2-0.7-0.2
Locomotion velocity, hab. session 10.60.93.11.8-1.7-0.5-0.60.30.2-0.10.2
Time in familiar zone, hab. session 20.40.41.2-0.10.10.50.8-0.40.71.10.5
Time in novel zone, hab. session 20.30.30.70.8-0.7-0.2-0.70.1-0.5-0.8-0.3
Total zone transitions, hab. session 20.20.20.60.1-0.0-0.7-0.30.8-0.4-0.3-0.4
Total locomotion distance, hab. session 20.20.30.6-0.10.1-0.8-0.60.7-0.4-0.8-0.5
Locomotion velocity, hab. session 20.20.30.7-0.40.4-0.6-0.50.6-0.4-0.8-0.4
Novel to familiar place preference ratio0.30.31.3-0.20.21.10.2-1.00.4-0.00.4
Novelty place preference0.70.72.4-0.20.21.50.5-1.30.80.20.8
Time in novel zone, NPP test0.70.82.20.0-0.01.50.6-1.40.90.40.8
Total zone transitions, NPP test1.11.64.32.1-2.0-1.4-0.81.3-0.2-0.2-0.1
Total locomotion distance, NPP test1.01.42.61.6-1.6-1.5-1.21.3-0.5-0.6-0.4
Locomotion velocity, NPP test1.01.42.51.6-1.5-1.5-1.21.3-0.4-0.6-0.4
Intraocular pressure0.30.52.01.4-1.20.2-0.20.1-0.00.5-0.0
Delta distance traveled before/after self-admin0.20.20.5-0.20.00.70.1-0.70.00.10.5
Delta ambulatory time before/after self-admin0.10.10.3-0.1-0.10.40.0-0.50.00.10.4
Parametrial fat weight3.88.817.31.0-0.9-3.0-4.23.1-3.2-3.8-2.9
Pavlov. Cond. lever latency1.11.33.1-0.30.21.81.0-1.71.21.01.2
Pavlov. Cond. magazine entry latency0.10.20.5-0.20.2-0.70.10.7-0.20.2-0.3
Pavlov. Cond. change in total contacts0.20.20.4-0.60.6-0.40.60.30.1-0.0-0.0
Pavlov. Cond. index score0.30.41.50.2-0.2-1.2-0.11.2-0.4-0.1-0.5
Pavlov. Cond. latency score0.60.72.10.1-0.1-1.5-0.41.5-0.7-0.4-0.8
Pavlov. Cond. lever contacts1.21.43.4-0.00.1-1.8-0.91.8-1.2-0.9-1.3
Pavlov. Cond. magazine entry number0.10.20.80.1-0.10.7-0.1-0.90.1-0.10.2
Pavlov. Cond. intertrial magazine entries1.51.73.5-0.30.3-1.3-1.80.9-1.7-1.9-1.3
Pavlov. Cond. lever-magazine prob. diff.0.60.72.1-0.10.1-1.4-0.41.4-0.7-0.5-0.9
Pavlov. Cond. response bias0.10.20.7-0.10.1-0.80.00.8-0.2-0.1-0.3
Pavlov. Cond. lever latency0.20.20.5-0.10.10.4-0.5-0.7-0.7-0.70.0
Pavlov. Cond. magazine entry latency0.10.20.40.1-0.2-0.70.30.60.30.60.0
Pavlov. Cond. change in total contacts0.81.32.81.7-1.7-0.20.60.21.41.50.8
Pavlov. Cond. index score0.20.31.10.2-0.2-1.00.21.00.20.5-0.4
Pavlov. Cond. latency score0.20.30.80.2-0.2-0.80.40.90.30.7-0.3
Pavlov. Cond. lever contacts0.20.20.6-0.20.2-0.40.50.80.50.6-0.1
Pavlov. Cond. magazine entry number0.40.51.2-0.80.81.10.2-1.00.0-0.40.3
Pavlov. Cond. intertrial magazine entries1.11.73.6-0.60.6-0.8-1.50.7-1.7-1.9-1.6
Pavlov. Cond. lever-magazine prob. diff.0.30.41.50.2-0.2-1.2-0.11.2-0.00.3-0.6
Pavlov. Cond. response bias0.20.30.60.4-0.5-0.60.40.80.60.80.0
Time in closed arm before self-admin0.50.71.10.3-0.5-1.0-1.00.8-0.9-0.9-1.0
Time in closed arm after self-admin0.20.31.0-0.81.00.20.5-0.3-0.0-0.1-0.0
Time in open arm before self-admin0.20.20.60.5-0.30.60.40.10.30.80.6
Time in open arm after self-admin0.10.10.2-0.1-0.00.3-0.3-0.2-0.2-0.4-0.3
Bone: periosteal estimation1.73.65.52.3-2.3-2.2-1.92.1-1.4-1.0-1.4
Bone: periosteal perimeter1.93.35.62.4-2.4-2.1-1.82.1-1.0-0.9-1.2
Bone: post-yield work3.34.87.70.1-0.1-2.6-2.42.5-2.8-2.3-2.5
Progressive ratio test 1 active lever presses0.40.41.4-0.70.71.2-0.3-0.8-0.1-0.6-0.2
Progressive ratio test 1 breakpoint0.30.41.2-0.60.61.1-0.3-0.7-0.2-0.7-0.2
Progressive ratio test 1 inactive lever presses0.10.20.4-0.40.60.60.0-0.30.0-0.5-0.1
Progressive ratio test 2 active lever presses0.40.41.50.4-0.31.2-0.0-1.00.70.20.6
Progressive ratio test 2 breakpoint0.50.51.70.4-0.41.30.1-1.10.70.30.7
Progressive ratio test 2 inactive lever presses0.30.51.10.6-0.51.10.3-0.81.00.50.8
Incentive Sensitization - Responses0.50.71.41.1-0.90.40.3-0.41.20.81.1
Incentive Sensitization - Breakpoint0.40.61.10.9-0.70.50.3-0.51.10.81.0
Sum of active levers in priming session hrs 5-60.30.30.70.8-0.8-0.6-0.40.60.20.1-0.1
Progressive ratio2.33.66.8-0.00.12.21.8-2.42.21.72.6
Food seeking constrained by brief footshock0.50.62.1-0.30.0-1.5-0.41.0-0.8-0.5-0.6
Seeking ratio, punishment vs. effort2.63.86.5-0.60.4-2.5-1.62.3-2.4-1.8-2.5
Retroperitoneal fat weight0.51.94.81.2-1.2-1.2-2.21.3-1.3-1.4-1.0
Reaction time number correct0.71.33.20.2-0.3-0.8-1.80.6-1.4-1.8-0.9
Reaction time mean minus median1.22.94.70.3-0.1-2.1-1.91.9-1.9-1.7-2.2
Reaction time mean minus median AUC0.20.51.1-0.10.2-0.6-0.80.6-0.8-0.6-1.0
Reaction time num false alarms0.71.01.80.2-0.3-1.4-1.01.3-1.1-0.9-0.9
Reaction time num false alarms AUC0.60.91.80.3-0.3-1.3-1.01.3-1.1-0.9-0.9
Reaction time trials correct on left0.71.33.20.2-0.3-0.8-1.80.6-1.4-1.8-0.9
Reaction time trials on left0.81.63.80.2-0.3-1.0-1.90.7-1.6-1.9-1.0
Reaction time mean1.01.62.80.6-0.6-1.5-1.71.6-1.3-1.2-1.4
Reaction time mean AUC1.01.62.70.5-0.4-1.4-1.61.6-1.3-1.2-1.4
Median of all reaction times0.50.71.30.5-0.5-0.9-1.11.1-0.7-0.7-0.8
Reaction time omissions0.71.11.8-0.20.3-1.2-1.21.2-1.2-1.3-1.1
Reaction time false alarm rate0.20.30.50.7-0.7-0.40.30.50.30.70.3
Reaction time premature initiation rate0.10.20.40.6-0.6-0.6-0.00.50.2-0.10.5
Reaction time premature initiations0.20.40.90.3-0.4-0.9-0.80.7-0.5-1.0-0.1
Std. dev. reaction times1.83.35.20.5-0.3-2.2-2.32.1-2.0-1.9-2.1
Reaction time trials completed0.81.63.80.2-0.3-1.0-1.90.7-1.6-1.9-1.0
Reaction time trials AUC0.61.23.20.4-0.4-0.8-1.80.6-1.3-1.7-0.9
Run reversals in cocaine runway, females0.60.61.6-1.01.20.50.8-0.60.3-0.10.6
Run reversals in cocaine runway, males0.40.40.80.00.1-0.7-0.90.6-0.8-0.7-0.8
Latency to leave start box in cocaine runway2.73.16.7-2.42.61.72.1-1.80.60.80.4
Latency to leave start box in cocaine runway, F3.13.510.1-3.03.21.52.0-1.60.20.4-0.2
Latency to leave start box in cocaine runway, M1.31.22.20.2-0.21.31.3-1.31.11.21.5
Std. dev. time between licks in bursts0.40.61.2-0.20.21.10.8-0.90.90.60.8
Total sessions with >9 infusions0.10.20.3-0.60.50.5-0.3-0.1-0.1-0.5-0.2
Short access day 1 total inactive lever presses0.20.30.70.3-0.2-0.5-0.80.8-0.4-0.1-0.3
Short access day 10 total inactive lever presses0.92.14.70.5-0.5-1.8-1.52.2-1.5-1.2-1.5
Short access day 1 total infusions0.60.82.1-0.20.1-0.8-1.01.5-0.8-0.9-1.1
Short access day 10 total infusions0.10.10.40.0-0.1-0.0-0.30.7-0.4-0.3-0.5
Short access total infusions0.00.10.1-0.40.30.30.00.30.1-0.2-0.2
Short access day 1 locomotion0.40.52.10.2-0.30.2-1.40.0-0.8-0.8-0.5
Short access day 10 total locomotion1.22.25.2-0.40.3-1.0-1.61.4-1.8-2.3-1.7
Short access total locomotion0.30.41.20.2-0.1-0.1-1.10.4-0.6-1.0-0.4
One hour access (0.3 mA shock)1.51.72.41.1-1.21.50.4-1.51.61.31.5
Compulsive drug intake0.40.51.4-0.60.4-0.10.7-1.20.80.41.0
One hour access (shock baseline)0.20.31.10.7-0.61.00.0-0.10.50.40.2
Social response proportion1.51.74.72.1-2.20.30.3-0.61.21.11.3
Social responses2.53.28.62.9-2.90.40.3-0.81.71.51.8
Social time0.30.51.41.2-1.1-0.20.40.10.40.9-0.0
Soleus weight1.23.56.72.6-2.6-1.9-2.11.6-1.2-1.1-1.0
Bone: stiffness1.01.73.10.9-0.9-1.7-1.41.8-1.0-1.1-1.2
Tibialis anterior weight2.27.327.15.2-5.2-0.8-0.60.51.11.20.7
Time to tail flick, vehicle, before self-admin0.20.30.5-0.70.60.70.7-0.5-0.1-0.2-0.2
Time to tail flick, vehicle, after self-admin3.34.48.1-0.80.5-2.1-2.12.8-2.4-2.3-2.6
Time to tail flick, test, before self-admin0.40.41.0-0.1-0.1-0.8-0.51.0-0.8-0.5-0.7
Time to tail flick, test, after self-admin0.10.10.4-0.10.10.20.60.40.20.60.1
Delta time to tail flick, vehicle, before/after SA1.71.65.20.3-0.4-1.7-1.32.3-0.9-0.7-1.3
Delta time to tail flick, test, before/after SA0.20.20.50.7-0.6-0.10.00.30.50.40.3
Tibia length1.84.97.82.7-2.7-2.2-2.82.0-1.6-1.7-1.7
Ambulatory time before self-admin0.30.41.10.3-0.3-1.1-0.70.8-0.5-0.5-0.6
Ambulatory time after self-admin0.10.10.3-0.2-0.1-0.4-0.60.3-0.4-0.5-0.3
Bone: tissue strength0.10.10.2-0.50.50.30.2-0.50.2-0.00.3
Total heroin consumption2.53.05.0-1.11.0-1.4-1.71.7-2.1-2.1-2.2
Bone: trabecular number2.13.56.11.4-1.41.52.0-1.42.22.52.2
Bone: trabecular spacing0.50.71.4-1.11.1-0.1-0.50.1-1.2-0.5-0.9
Bone: trabecular thickness1.21.42.21.1-1.11.11.0-1.11.51.21.5
Bone: trabecular tissue density1.21.86.2-2.52.50.6-0.1-0.6-0.2-0.9-0.2
Water consumed over 24 hours3.64.98.5-1.21.2-2.4-2.02.9-2.5-2.3-2.5
Number of responses in last shaping day1.71.94.1-0.70.7-0.8-0.81.1-1.9-2.0-2.0