Hub : Genes

Ryr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	Ryr2	0.15	0.09	1.8e-03	0.03	0.09	0.04	0.03	4.9e-02	2.8e-03	4.1e-02	4.6e-02
2	NAcc	gene expression	Ryr2	0.02	0.01	1.3e-03	0.03	0.01	0	0.01	9.6e-05	4.0e-03	4.4e-02	4.1e-03
3	pVTA	alternative TSS	NM_032078.3	0.02	0.02	9.8e-03	0.04	0.02	0.03	0.04	1.7e-04	1.6e-02	2.1e-03	8.0e-04
4	pVTA	alternative TSS	NM_032078.3	0.02	0.02	7.9e-03	0.04	0.02	0.03	0.03	2.6e-04	8.7e-03	2.6e-03	8.8e-04
5	NAcc	intron excision ratio	chr17_63606512_63617515	0.02	0.01	3.7e-03	0.01	0.01	0	0	2.8e-03	2.6e-02	8.4e-02	6.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.2	-0.3	-0.5	0.5	0.5	0.3
Area under the delay curve	0.2	0.2	0.3	0.1	0.6	-0.6	-0.6	0.1
BMI with tail	0.1	0.4	1.7	0.3	-0.2	0.2	0.2	-1.3
BMI without tail	0.7	2.1	2.5	1.4	1.4	-1.4	-1.4	-1.6
Body weight	2.1	9.4	15.3	3.9	2.5	-2.5	-2.5	-3.5
Weight adjusted by age	0.7	1.0	1.6	-0.3	-1.3	1.3	1.3	0.1
Bone surface	1.0	1.9	2.5	1.6	1.5	-1.5	-1.5	-0.5
Bone volume	0.8	1.5	2.0	1.3	1.4	-1.4	-1.4	-0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	-0.1	0.1	0.1	-0.5
Number of licking bursts	0.8	1.3	1.5	-0.9	-1.2	1.2	1.2	1.0
Context. condit. distance diff. score	0.3	0.4	0.6	-0.6	-0.7	0.7	0.7	-0.0
Locomotion velocity, session 1	1.0	1.1	1.5	-1.0	-1.2	1.2	1.2	0.2
Locomotion distance, session 1	4.0	5.0	6.5	-2.0	-2.5	2.5	2.5	1.4
Locomotion velocity, session 2	0.7	0.8	2.2	0.1	-0.8	0.8	0.8	-1.5
Locomotion distance, session 2	2.6	3.7	4.6	-1.8	-2.2	2.2	2.2	1.1
Locomotion velocity, session 3	0.6	0.6	1.3	-0.1	-0.8	0.8	0.8	-1.1
Locomotion distance, session 3	0.2	0.3	1.2	0.2	-0.1	0.1	0.1	-1.1
Stereotopy head waving bouts, day 3	3.2	3.8	5.8	2.0	1.8	-1.8	-1.8	-2.4
Stereotopy head waving duration, day 3	1.9	2.3	3.9	1.6	1.3	-1.3	-1.3	-2.0
Locomotion velocity, session 7	1.2	1.3	5.6	1.0	0.1	-0.1	-0.1	-2.4
Locomotion distance, session 7	0.8	1.0	1.3	-1.1	-1.1	1.1	1.1	0.5
Stereotopy head waving bouts, day 7	1.5	1.7	2.0	1.4	1.2	-1.2	-1.2	-1.4
Stereotopy head waving duration, day 7	0.9	1.1	1.4	1.2	1.2	-1.2	-1.2	-0.6
Locomotion velocity, session 8	0.3	0.3	0.4	-0.2	-0.6	0.6	0.6	-0.5
Locomotion distance, session 8	1.5	2.2	3.1	-1.2	-1.7	1.7	1.7	0.5
Degree of sensitization distance	1.1	1.2	2.8	-1.2	-0.7	0.7	0.7	1.7
Degree of sensitization stereotypy	0.7	0.7	1.0	1.0	0.9	-0.9	-0.9	-0.4
Conditioned locomotion	0.2	0.3	0.8	-0.5	0.3	-0.3	-0.3	0.9
Cocaine response after cond. corrected	0.8	1.0	1.2	-0.9	-1.1	1.1	1.1	0.7
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.1	-0.5	0.5	0.5	0.1
Cocaine response before conditioning	1.6	1.9	2.7	1.7	1.4	-1.4	-1.4	-1.2
Saline control response	3.1	4.1	5.2	1.9	2.3	-2.3	-2.3	-1.1
Bone: connectivity density	0.4	0.6	0.9	-0.5	-0.8	0.8	0.8	1.0
Bone: cortical apparent density	0.3	0.4	0.5	0.6	0.7	-0.7	-0.7	-0.4
Bone: cortical area	0.0	0.1	0.1	0.2	0.3	-0.3	-0.3	0.2
Bone: cortical porosity	0.2	0.2	0.4	0.6	0.4	-0.4	-0.4	-0.0
Bone: cortical porosity	0.0	0.1	0.2	0.4	0.2	-0.2	-0.2	0.2
Bone: cortical thickness	0.1	0.2	0.4	-0.6	-0.5	0.5	0.5	0.1
Bone: cortical thickness	0.1	0.2	0.5	0.3	0.3	-0.3	-0.3	-0.7
Bone: cortical tissue density	0.3	0.4	0.5	0.6	0.7	-0.7	-0.7	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	-0.0	0.3	-0.3	-0.3	0.8
Condit. Reinf. active responses	2.7	3.4	3.7	1.9	1.8	-1.8	-1.8	-1.9
Condit. Reinf. inactive responses	3.0	3.7	6.1	2.0	1.7	-1.7	-1.7	-2.5
Incentive salience index mean	0.9	1.1	1.3	1.2	1.1	-1.1	-1.1	-0.9
Condit. Reinf. lever presses	0.8	1.1	1.5	1.2	0.9	-0.9	-0.9	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.4	0.2	-0.2	-0.2	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.2	0.2	0.2	0.3
Condit. Reinf. active responses	0.9	1.3	1.5	1.2	1.1	-1.1	-1.1	-1.1
Condit. Reinf. inactive responses	1.0	1.4	1.7	1.3	1.2	-1.2	-1.2	-0.9
Condit. Reinf. lever presses	0.4	0.5	0.8	-0.6	-0.9	0.9	0.9	0.1
Condit. Reinf. lever reinforcers received	0.6	0.8	0.9	0.9	0.9	-0.9	-0.9	-0.8
Conditioned reinforcement - actives	0.0	0.1	0.1	0.0	0.3	-0.3	-0.3	0.2
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.6	0.3	-0.3	-0.3	0.6
Conditioned locomotion	0.0	0.1	0.3	-0.5	-0.1	0.1	0.1	0.1
Patch foraging indifference point 0 sec	0.2	0.3	0.3	-0.5	-0.6	0.6	0.6	-0.5
Patch foraging indifference point AUC	0.0	0.0	0.1	0.4	0.1	-0.1	-0.1	0.1
Delay disc. indifference point, 0s delay	0.3	0.3	1.2	-0.4	0.3	-0.3	-0.3	1.1
Delay disc. indifference point, 16s delay	2.0	2.2	2.8	1.0	1.7	-1.7	-1.7	-1.3
Delay disc. indifference point, 2s delay	0.3	0.3	1.2	-0.7	-0.1	0.1	0.1	1.1
Delay disc. indifference point, 24s delay	0.2	0.3	1.1	0.4	0.2	-0.2	-0.2	-1.0
Delay disc. indifference point, 4s delay	2.2	2.3	5.4	-1.5	-1.1	1.1	1.1	2.3
Delay disc. indifference point, 8s delay	0.4	0.5	0.8	0.8	0.6	-0.6	-0.6	-0.9
Indifference point function ln k	0.1	0.1	0.5	-0.7	-0.1	0.1	0.1	0.4
Indifference point function log k	0.1	0.1	0.5	-0.7	-0.1	0.1	0.1	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4	-0.6
Patch foraging total patch changes 12 sec	0.4	0.5	0.7	-0.3	-0.8	0.8	0.8	-0.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.3	-0.7	0.7	0.7	0.4
Patch foraging total patch changes 24 sec	0.2	0.4	1.0	0.8	0.3	-0.3	-0.3	-1.0
Patch foraging total patch changes 6 sec	0.5	0.8	1.1	-0.7	-1.1	1.1	1.1	0.0
Patch foraging time to switch 0 sec	0.4	0.8	1.6	1.3	0.5	-0.5	-0.5	-1.3
Patch foraging water rate 0 sec	0.1	0.3	0.4	-0.1	0.6	-0.6	-0.6	0.1
Patch foraging water rate 12 sec	0.6	1.3	1.4	-1.2	-1.1	1.1	1.1	1.2
Patch foraging water rate 18 sec	0.4	0.7	1.0	0.4	1.0	-1.0	-1.0	-0.5
Patch foraging water rate 24 sec	0.1	0.2	0.3	-0.1	0.5	-0.5	-0.5	0.2
Patch foraging water rate 6 sec	0.4	0.6	0.7	0.8	0.8	-0.8	-0.8	-0.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.6	0.4	-0.6	0.6	0.6	-0.8
Distance traveled before self-admin	0.2	0.3	0.4	-0.3	-0.6	0.6	0.6	-0.6
Distance traveled after self-admin	0.8	1.0	1.5	-1.2	-1.1	1.1	1.1	0.4
Extensor digitorum longus weight	0.5	2.1	2.5	1.4	1.6	-1.6	-1.6	-1.0
Bone: elastic displacement	0.1	0.1	0.1	-0.2	-0.4	0.4	0.4	0.2
Bone: elastic work	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5	0.5
Bone: endosteal estimation	1.8	3.9	4.7	2.1	2.2	-2.2	-2.2	-1.0
Bone: endosteal perimeter	1.1	2.4	3.3	1.5	1.8	-1.8	-1.8	0.0
Epididymis fat weight	0.8	2.6	5.4	2.3	1.3	-1.3	-1.3	-1.6
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	-0.5	-0.4	0.4	0.4	0.9
Delta time in open arm before/after self-admin	0.9	0.9	1.2	0.8	1.1	-1.1	-1.1	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	0.6	-0.2	-0.7	0.7	0.7	-0.8
Delay discount exponential model param	0.1	0.1	0.2	0.0	-0.4	0.4	0.4	-0.2
Extinction: sum of active levers before priming	0.4	0.5	0.8	0.0	-0.9	0.9	0.9	0.0
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.3	-0.1	0.1	0.1	0.5
Bone: final force	0.1	0.2	0.2	0.1	0.5	-0.5	-0.5	-0.2
Bone: final moment	0.1	0.2	0.3	0.3	0.5	-0.5	-0.5	-0.4
Food consumed during 24 hour testing period	1.5	2.1	2.8	-1.5	-1.7	1.7	1.7	0.3
Glucose	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2	-0.2
Heart weight	0.9	1.3	1.9	-1.1	-1.4	1.4	1.4	0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.3	0.3	0.3	-0.4
Intermittent access intake day 1-15 change	0.4	0.8	1.1	-0.7	-1.0	1.0	1.0	0.6
Intermittent access intake escalation	0.2	0.5	0.7	-0.5	-0.8	0.8	0.8	0.3
Intermittent access intake escalation 2	0.5	0.5	0.8	-0.5	-0.8	0.8	0.8	0.9
Intermitt. access day 1 inactive lever presses	0.4	1.5	3.5	-1.9	-0.9	0.9	0.9	1.4
Intermitt. access day 15 inactive lever presses	0.3	0.5	0.7	-0.1	0.9	-0.9	-0.9	-0.7
Intermitt. access escalation Index	0.1	0.1	0.5	-0.1	0.1	-0.1	-0.1	0.7
Intermittent access day 1 total infusions	1.3	2.1	2.4	-1.3	-1.5	1.5	1.5	1.2
Intermittent access day 15 total infusions	1.9	2.9	3.4	-1.5	-1.8	1.8	1.8	1.3
Intermittent access terminal intake (last 3 days)	1.8	2.4	2.9	-1.2	-1.7	1.7	1.7	1.4
Intermittent access total infusions	1.2	1.5	1.8	-1.1	-1.3	1.3	1.3	1.0
Intermittent access day 1 locomotion	2.2	2.8	3.7	-1.9	-1.7	1.7	1.7	1.3
Intermittent access day 15 total locomotion	1.8	3.3	4.1	-2.0	-1.9	1.9	1.9	1.4
Intermittent access total locomotion	1.8	2.2	3.4	-1.8	-1.5	1.5	1.5	1.0
Intermittent access standard deviation	0.4	0.8	0.9	-0.8	-0.9	0.9	0.9	0.7
Left kidney weight	1.4	6.7	10.8	2.8	2.2	-2.2	-2.2	-3.3
Right kidney weight	0.6	2.8	5.6	1.9	1.2	-1.2	-1.2	-2.4
Cocaine induced anxiety	0.2	0.3	1.1	-0.5	-0.3	0.3	0.3	1.0
Post-drug Anxiety	0.3	0.4	0.7	0.8	0.6	-0.6	-0.6	-0.1
Baseline Anxiety	1.1	1.3	2.9	1.2	0.8	-0.8	-0.8	-1.7
Tail length	3.0	11.6	16.1	4.0	3.4	-3.4	-3.4	-2.6
Length with tail	4.3	18.7	29.2	5.4	4.1	-4.1	-4.1	-3.8
Length without tail	2.1	6.6	11.9	3.4	2.2	-2.2	-2.2	-2.6
Times rat made contact with spout	0.1	0.1	0.4	0.1	-0.2	0.2	0.2	-0.6
Lifetime Intake	1.1	1.4	1.7	-1.1	-1.3	1.3	1.3	0.9
Liver weight, left	0.2	0.4	0.8	0.9	0.6	-0.6	-0.6	0.0
Liver weight, right	0.1	0.2	0.2	0.4	0.5	-0.5	-0.5	-0.1
Locomotor activity	0.7	1.1	1.4	-1.0	-1.2	1.2	1.2	0.5
Locomotor testing distance	0.2	0.4	0.6	-0.6	-0.8	0.8	0.8	0.1
Locomotor testing rearing	0.2	0.5	1.0	0.3	-0.7	0.7	0.7	-1.0
Locomotion in novel chamber	0.1	0.1	0.3	0.1	-0.2	0.2	0.2	-0.6
Locomotion in novel chamber post-restriction	0.3	0.5	1.5	0.7	0.4	-0.4	-0.4	-1.2
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.0	0.0	0.0	0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	0.2
Time >=10cm from walls, locomotor time 1	0.7	0.8	1.0	0.6	1.0	-1.0	-1.0	-0.7
Bouts of movement, locomotor time 1	0.3	0.4	0.5	0.5	0.7	-0.7	-0.7	-0.1
Total resting periods, locomotor time 1	0.5	0.5	0.8	0.5	0.9	-0.9	-0.9	-0.1
Rest time, locomotor task time 1	0.7	0.9	1.8	-0.4	0.9	-0.9	-0.9	1.3
Distance moved, locomotor task time 1	0.6	0.9	3.1	0.7	-0.5	0.5	0.5	-1.8
Vertical activity count, locomotor time 1	0.4	0.8	3.0	0.5	-0.6	0.6	0.6	-1.7
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.8	-0.9	-0.3	0.3	0.3	0.7
Bouts of movement, locomotor time 2	1.3	2.0	2.4	1.6	1.4	-1.4	-1.4	-1.2
Total resting periods, locomotor time 2	1.5	2.6	3.1	1.8	1.6	-1.6	-1.6	-1.4
Rest time, locomotor task time 2	0.9	1.2	1.5	1.2	1.2	-1.2	-1.2	-0.7
Distance moved, locomotor task time 2	0.1	0.1	0.7	0.0	-0.1	0.1	0.1	-0.8
Vertical activity count, locomotor time 2	0.3	0.4	1.3	0.1	0.4	-0.4	-0.4	-1.1
Light reinforcement 1	0.7	1.8	3.8	1.3	1.1	-1.1	-1.1	-1.9
Light reinforcement 2	0.2	0.3	1.2	0.4	0.2	-0.2	-0.2	-1.1
Bone: marrow area	1.8	3.9	4.6	2.1	2.1	-2.1	-2.1	-1.1
Bone: maximum diameter	0.7	1.3	1.8	1.3	1.2	-1.2	-1.2	-0.3
Bone: maximum force	0.0	0.1	0.1	0.0	0.3	-0.3	-0.3	-0.1
Bone: maximum moment	0.0	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.2
Mean time between licks in bursts	0.4	0.9	1.5	1.2	0.8	-0.8	-0.8	-1.1
Mean num. licks in bursts	0.8	1.2	1.7	0.9	1.1	-1.1	-1.1	-1.3
Cd content in liver	4.7	5.3	5.9	-2.3	-2.4	2.4	2.4	1.8
Co content in liver	2.8	3.3	3.6	-1.8	-1.9	1.9	1.9	1.6
Cu content in liver	0.9	1.1	1.3	1.0	1.2	-1.2	-1.2	-0.6
Fe content in liver	0.6	0.7	1.3	1.1	0.8	-0.8	-0.8	-0.7
K content in liver	1.4	1.4	2.6	1.6	0.9	-0.9	-0.9	-1.4
Mg content in liver	0.9	1.0	1.9	1.4	0.9	-0.9	-0.9	-0.6
Mn content in liver	3.5	3.8	4.8	2.0	2.2	-2.2	-2.2	-0.9
Na content in liver	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1
Rb content in liver	0.0	0.0	0.2	0.5	0.0	-0.0	-0.0	0.0
Se content in liver	3.4	4.0	4.7	2.2	1.9	-1.9	-1.9	-2.1
Sr content in liver	0.1	0.0	0.2	0.0	-0.1	0.1	0.1	-0.5
Zn content in liver	0.3	0.4	1.1	0.7	0.3	-0.3	-0.3	-1.1
Bone: minimum diameter	0.2	0.3	1.4	-0.3	-0.1	0.1	0.1	1.2
Time in familiar zone, hab. session 1	0.8	0.7	0.9	0.8	1.0	-1.0	-1.0	-0.5
Time in novel zone, hab. session 1	0.8	0.8	0.9	-0.9	-0.9	0.9	0.9	0.8
Total zone transitions, hab. session 1	2.2	3.1	6.7	-2.0	-1.3	1.3	1.3	2.6
Total locomotion distance, hab. session 1	0.8	1.1	1.5	-0.7	-1.1	1.1	1.1	1.2
Locomotion velocity, hab. session 1	0.7	1.0	1.3	-0.6	-1.1	1.1	1.1	0.9
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.3	0.3	0.3	0.4
Time in novel zone, hab. session 2	0.5	0.5	0.6	-0.5	-0.8	0.8	0.8	0.6
Total zone transitions, hab. session 2	0.8	1.0	1.1	-1.0	-1.1	1.1	1.1	0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.7	0.3	-0.3	-0.3	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.8	0.3	-0.3	-0.3	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.6	-0.2	0.1	-0.1	-0.1	0.8
Novelty place preference	0.2	0.2	1.0	-0.4	-0.1	0.1	0.1	1.0
Time in novel zone, NPP test	0.2	0.2	1.0	-0.4	-0.0	0.0	0.0	1.0
Total zone transitions, NPP test	0.1	0.1	0.4	-0.4	-0.1	0.1	0.1	0.7
Total locomotion distance, NPP test	0.1	0.2	0.3	0.6	0.4	-0.4	-0.4	-0.1
Locomotion velocity, NPP test	0.0	0.1	0.1	0.4	0.2	-0.2	-0.2	0.3
Intraocular pressure	0.9	1.3	1.7	-0.9	-1.3	1.3	1.3	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.4	-0.0	0.0	0.0	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.3	0.6
Parametrial fat weight	0.3	0.7	2.4	1.0	0.2	-0.2	-0.2	-1.5
Pavlov. Cond. lever latency	1.4	1.7	2.2	-1.1	-1.5	1.5	1.5	0.9
Pavlov. Cond. magazine entry latency	1.8	2.4	3.4	1.2	1.9	-1.9	-1.9	-0.4
Pavlov. Cond. change in total contacts	1.5	1.6	2.3	0.9	1.5	-1.5	-1.5	-0.5
Pavlov. Cond. index score	1.5	1.9	2.6	1.1	1.6	-1.6	-1.6	-0.7
Pavlov. Cond. latency score	1.8	2.3	3.0	1.3	1.7	-1.7	-1.7	-0.9
Pavlov. Cond. lever contacts	0.8	1.0	1.3	0.9	1.1	-1.1	-1.1	-0.7
Pavlov. Cond. magazine entry number	1.4	1.8	2.6	-0.9	-1.6	1.6	1.6	0.4
Pavlov. Cond. intertrial magazine entries	1.8	2.2	3.4	-0.8	-1.8	1.8	1.8	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.2	0.9	1.5	-1.5	-1.5	-0.6
Pavlov. Cond. response bias	1.1	1.4	2.1	0.8	1.4	-1.4	-1.4	-0.2
Pavlov. Cond. lever latency	0.5	0.7	0.9	0.1	0.9	-0.9	-0.9	0.9
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.4	-0.6	0.6	0.6	0.3
Pavlov. Cond. change in total contacts	0.3	0.5	0.8	-0.1	-0.9	0.9	0.9	-0.4
Pavlov. Cond. index score	0.4	0.5	0.8	-0.2	-0.9	0.9	0.9	-0.4
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.0	-0.8	0.8	0.8	-0.5
Pavlov. Cond. lever contacts	0.8	1.2	1.8	-0.6	-1.3	1.3	1.3	-0.5
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	0.3	0.7	-0.7	-0.7	-0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.0	0.3	-0.3	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.2	-0.9	0.9	0.9	-0.3
Pavlov. Cond. response bias	0.6	0.8	1.2	-0.6	-1.1	1.1	1.1	-0.2
Time in closed arm before self-admin	0.6	0.8	1.1	-1.0	-0.9	0.9	0.9	0.6
Time in closed arm after self-admin	1.2	1.3	1.8	-1.1	-1.1	1.1	1.1	1.3
Time in open arm before self-admin	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2
Time in open arm after self-admin	1.5	1.6	1.7	1.3	1.3	-1.3	-1.3	-1.3
Bone: periosteal estimation	1.3	2.7	3.3	1.8	1.8	-1.8	-1.8	-0.9
Bone: periosteal perimeter	0.9	1.5	2.1	1.1	1.5	-1.5	-1.5	0.1
Bone: post-yield work	0.2	0.3	0.5	0.4	0.7	-0.7	-0.7	-0.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	-0.2	0.2	0.2	0.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	-0.6	0.3	-0.3	-0.3	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.6	-0.3	-0.1	0.1	0.1	0.8
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.3	-0.0	0.0	0.0	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	-0.7	-0.1	0.1	0.1	0.7
Incentive Sensitization - Responses	0.2	0.3	1.1	-0.1	0.3	-0.3	-0.3	1.1
Incentive Sensitization - Breakpoint	0.2	0.3	1.3	-0.3	0.2	-0.2	-0.2	1.1
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.1	-1.0	-0.9	0.9	0.9	0.7
Progressive ratio	0.1	0.1	0.4	0.3	0.1	-0.1	-0.1	-0.6
Food seeking constrained by brief footshock	4.3	5.2	6.4	2.4	2.5	-2.5	-2.5	-1.1
Seeking ratio, punishment vs. effort	1.4	2.0	2.5	1.4	1.6	-1.6	-1.6	-0.5
Retroperitoneal fat weight	1.3	5.5	9.7	2.6	1.9	-1.9	-1.9	-3.1
Reaction time number correct	0.5	0.9	1.7	-1.0	-0.7	0.7	0.7	1.3
Reaction time mean minus median	0.1	0.3	1.2	0.0	0.0	-0.0	-0.0	1.1
Reaction time mean minus median AUC	0.2	0.4	2.1	-0.2	-0.1	0.1	0.1	1.4
Reaction time num false alarms	0.2	0.3	0.5	-0.7	-0.5	0.5	0.5	0.3
Reaction time num false alarms AUC	0.2	0.2	0.5	-0.7	-0.3	0.3	0.3	0.7
Reaction time trials correct on left	0.5	0.9	1.7	-1.0	-0.7	0.7	0.7	1.3
Reaction time trials on left	0.4	0.8	1.6	-1.0	-0.7	0.7	0.7	1.3
Reaction time mean	1.1	1.8	1.9	-1.4	-1.4	1.4	1.4	1.2
Reaction time mean AUC	0.4	0.7	0.8	-0.9	-0.8	0.8	0.8	0.9
Median of all reaction times	2.1	2.9	3.6	-1.9	-1.8	1.8	1.8	1.2
Reaction time omissions	0.1	0.2	0.6	-0.0	-0.3	0.3	0.3	0.8
Reaction time false alarm rate	0.0	0.0	0.0	-0.2	-0.0	0.0	0.0	-0.0
Reaction time premature initiation rate	1.5	2.0	2.7	1.3	1.6	-1.6	-1.6	-0.6
Reaction time premature initiations	0.4	0.8	1.1	0.7	1.1	-1.1	-1.1	0.1
Std. dev. reaction times	0.2	0.4	1.5	-0.4	-0.2	0.2	0.2	1.2
Reaction time trials completed	0.4	0.8	1.6	-1.0	-0.7	0.7	0.7	1.3
Reaction time trials AUC	0.4	0.8	1.7	-1.0	-0.7	0.7	0.7	1.3
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.9	-0.1	0.1	0.1	-0.8
Run reversals in cocaine runway, males	1.1	1.1	1.6	-0.8	-1.3	1.3	1.3	0.4
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.6	-0.2	0.1	-0.1	-0.1	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.1	-0.3	0.3	0.3	-0.3
Std. dev. time between licks in bursts	0.4	0.6	1.5	1.2	0.6	-0.6	-0.6	-0.7
Total sessions with >9 infusions	0.8	1.0	1.3	-1.1	-1.1	1.1	1.1	0.3
Short access day 1 total inactive lever presses	1.3	1.8	3.5	-1.8	-0.9	0.9	0.9	1.9
Short access day 10 total inactive lever presses	0.8	1.8	3.0	0.6	1.7	-1.7	-1.7	-0.1
Short access day 1 total infusions	0.6	0.8	1.0	-0.8	-1.0	1.0	1.0	0.7
Short access day 10 total infusions	1.4	1.8	2.1	-1.2	-1.5	1.5	1.5	1.1
Short access total infusions	0.4	0.5	0.7	-0.5	-0.9	0.9	0.9	0.4
Short access day 1 locomotion	1.0	1.3	1.7	-1.1	-1.3	1.3	1.3	0.4
Short access day 10 total locomotion	0.0	0.1	0.3	-0.6	0.1	-0.1	-0.1	0.4
Short access total locomotion	0.4	0.4	1.1	-1.1	-0.6	0.6	0.6	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.6	-0.5	0.2	-0.2	-0.2	0.7
Compulsive drug intake	3.2	3.8	4.8	1.9	2.2	-2.2	-2.2	-1.1
One hour access (shock baseline)	1.8	2.8	3.0	-1.7	-1.7	1.7	1.7	1.5
Social response proportion	0.6	0.7	1.4	-0.8	-0.7	0.7	0.7	1.2
Social responses	0.1	0.1	0.2	-0.4	-0.3	0.3	0.3	0.3
Social time	2.6	3.5	4.3	-1.9	-2.1	2.1	2.1	1.0
Soleus weight	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	0.2
Bone: stiffness	0.1	0.2	0.4	-0.2	0.5	-0.5	-0.5	0.6
Tibialis anterior weight	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	-0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.0	-0.7	0.7	0.7	-0.1
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.7	1.2	0.1	-0.1	-0.1	-1.6
Time to tail flick, test, before self-admin	1.8	1.9	2.6	1.2	1.6	-1.6	-1.6	0.0
Time to tail flick, test, after self-admin	0.7	0.8	2.1	1.3	-0.1	0.1	0.1	-1.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.3	0.4	-0.4	-0.4	-0.5
Delta time to tail flick, test, before/after SA	1.0	1.0	1.8	0.3	-1.0	1.0	1.0	-1.3
Tibia length	1.6	4.3	5.7	2.4	2.0	-2.0	-2.0	-1.8
Ambulatory time before self-admin	0.5	0.7	1.0	-0.7	-1.0	1.0	1.0	-0.3
Ambulatory time after self-admin	0.8	1.0	1.2	-1.0	-1.1	1.1	1.1	0.4
Bone: tissue strength	2.6	2.6	3.1	-1.8	-1.6	1.6	1.6	1.4
Total heroin consumption	1.3	1.5	2.1	-0.8	-1.5	1.5	1.5	0.5
Bone: trabecular number	0.2	0.4	0.5	-0.4	-0.7	0.7	0.7	0.4
Bone: trabecular spacing	0.0	0.1	0.1	-0.1	0.3	-0.3	-0.3	0.2
Bone: trabecular thickness	0.6	0.7	0.9	0.8	0.9	-0.9	-0.9	-0.5
Bone: trabecular tissue density	0.1	0.1	0.3	-0.3	-0.1	0.1	0.1	0.5
Water consumed over 24 hours	0.1	0.1	0.1	0.0	-0.4	0.4	0.4	-0.0
Number of responses in last shaping day	1.3	1.4	1.8	-0.9	-1.4	1.4	1.4	0.8