Hub : Genes

Ryr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ryr1 0.1 0.06 2.0e-12 0.07 0.08 0.07 0.07 8.1e-08 3.9e-09 6.7e-08 4.9e-08
2 pVTA gene expression Ryr1 0.09 0.06 7.0e-09 0.09 0.05 0.06 0.06 6.7e-08 1.4e-04 7.6e-06 3.2e-05
3 RMTg gene expression Ryr1 0.11 0.08 2.1e-03 0.08 0.08 0.07 0.03 3.9e-03 4.3e-03 5.9e-03 6.4e-02
4 Adipose gene expression Ryr1 0.31 0.21 0.0e+00 0.11 0.12 0.11 0.11 5.8e-12 1.1e-12 2.4e-12 2.0e-12
5 pVTA isoform ratio XM_039100852.2 0.06 0.08 8.6e-03 0.02 -0 0.01 0 5.9e-03 7.8e-01 4.4e-02 2.1e-01
6 LHb gene expression Ryr1 0.18 0.12 3.3e-04 0.12 0.12 0.08 0.1 8.8e-04 9.3e-04 5.9e-03 2.5e-03
7 NAcc intron excision ratio chr1_93462988_93464129 0.04 0.04 1.4e-05 0.02 0.02 0.02 0.02 1.1e-04 2.7e-04 1.2e-03 4.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.00.00.10.10.10.2-0.30.20.3-0.3
Area under the delay curve0.10.10.6-0.80.1-0.1-0.00.1-0.10.0
BMI with tail0.10.20.40.60.30.6-0.30.10.4-0.4
BMI without tail0.61.82.0-1.3-1.4-1.21.3-1.3-1.41.3
Body weight2.310.011.3-3.4-3.3-3.23.2-2.9-3.03.1
Weight adjusted by age0.00.00.10.20.3-0.00.1-0.2-0.10.1
Bone surface0.20.40.6-0.8-0.7-0.70.6-0.6-0.60.6
Bone volume0.30.50.7-0.9-0.8-0.80.7-0.6-0.70.6
Breakpoint value in progressive ratio session1.62.03.0-1.7-1.3-1.31.4-1.4-1.31.3
Number of licking bursts1.52.53.51.81.91.5-1.51.31.5-1.5
Context. condit. distance diff. score0.10.10.20.20.40.4-0.4-0.00.1-0.1
Locomotion velocity, session 12.42.63.51.41.91.6-1.61.51.6-1.6
Locomotion distance, session 10.81.01.1-1.0-0.9-1.01.0-0.9-1.01.0
Locomotion velocity, session 20.40.50.70.80.50.7-0.80.50.6-0.7
Locomotion distance, session 20.50.71.41.20.80.8-0.60.90.8-0.8
Locomotion velocity, session 30.20.20.40.60.50.3-0.50.40.3-0.3
Locomotion distance, session 36.67.28.0-2.5-2.7-2.62.7-2.8-2.72.7
Stereotopy head waving bouts, day 30.40.41.11.10.80.5-0.60.50.5-0.5
Stereotopy head waving duration, day 32.53.03.61.91.81.6-1.81.71.7-1.7
Locomotion velocity, session 70.00.00.0-0.1-0.20.0-0.10.1-0.10.0
Locomotion distance, session 70.10.10.2-0.4-0.4-0.30.3-0.3-0.30.3
Stereotopy head waving bouts, day 70.20.20.70.80.50.5-0.30.20.4-0.4
Stereotopy head waving duration, day 70.80.91.61.31.01.0-0.80.80.9-0.9
Locomotion velocity, session 83.13.75.02.22.22.0-1.91.61.7-1.7
Locomotion distance, session 80.40.50.90.90.90.8-0.60.40.6-0.6
Degree of sensitization distance3.73.94.51.61.92.0-2.12.12.0-2.0
Degree of sensitization stereotypy0.00.00.10.30.0-0.00.3-0.3-0.10.1
Conditioned locomotion0.80.91.7-0.3-0.9-0.90.8-1.3-1.11.1
Cocaine response after cond. corrected0.40.50.7-0.6-0.9-0.70.7-0.8-0.70.7
Cocaine response after cond. not corrected0.70.81.0-0.6-1.0-0.91.0-0.9-0.90.9
Cocaine response before conditioning1.51.72.4-0.9-1.2-1.61.4-1.3-1.41.4
Saline control response0.10.10.2-0.3-0.3-0.30.4-0.5-0.30.3
Bone: connectivity density0.40.60.90.60.80.8-0.90.70.8-0.8
Bone: cortical apparent density2.53.44.11.92.01.9-1.71.91.8-1.8
Bone: cortical area2.53.94.4-1.9-1.9-2.12.0-1.9-2.02.0
Bone: cortical porosity0.30.31.21.10.40.5-0.40.20.4-0.4
Bone: cortical porosity0.40.51.51.20.60.6-0.50.40.5-0.5
Bone: cortical thickness1.52.52.9-1.4-1.4-1.71.6-1.7-1.61.6
Bone: cortical thickness0.00.00.20.50.2-0.0-0.1-0.2-0.00.0
Bone: cortical tissue density2.83.94.52.12.12.0-1.82.01.9-1.9
Condit. Reinf. active minus inactive responses0.20.20.40.60.60.4-0.60.40.4-0.4
Condit. Reinf. active-inactive response ratio0.10.10.20.40.40.3-0.40.30.3-0.3
Condit. Reinf. active responses1.01.32.01.41.01.1-1.11.01.1-1.1
Condit. Reinf. inactive responses0.80.91.41.20.81.0-0.80.91.0-1.0
Incentive salience index mean0.00.00.10.30.10.1-0.20.10.1-0.1
Condit. Reinf. lever presses0.10.10.3-0.2-0.6-0.40.3-0.2-0.30.3
Condit. Reinf. active minus inactive responses4.25.46.3-2.2-2.3-2.32.3-2.5-2.42.4
Condit. Reinf. active-inactive response ratio3.03.44.2-1.3-1.8-1.82.0-2.1-1.91.9
Condit. Reinf. active responses4.96.87.7-2.6-2.5-2.62.5-2.8-2.62.6
Condit. Reinf. inactive responses1.21.62.7-1.6-1.0-1.31.1-1.3-1.21.2
Condit. Reinf. lever presses7.29.912.7-3.6-3.0-3.12.9-3.2-3.13.1
Condit. Reinf. lever reinforcers received6.08.39.3-2.8-2.8-2.92.8-3.1-2.92.9
Conditioned reinforcement - actives0.10.10.40.60.30.4-0.4-0.00.2-0.2
Conditioned reinforcement - inactives0.60.91.3-0.8-0.9-0.90.7-1.0-1.11.1
Conditioned locomotion1.72.24.12.01.31.5-1.51.11.3-1.3
Patch foraging indifference point 0 sec0.20.40.5-0.5-0.3-0.70.6-0.6-0.60.7
Patch foraging indifference point AUC0.71.01.70.90.40.8-0.61.21.3-1.3
Delay disc. indifference point, 0s delay0.20.20.8-0.9-0.3-0.40.5-0.2-0.30.3
Delay disc. indifference point, 16s delay1.21.32.7-1.7-0.9-1.10.9-1.0-1.11.2
Delay disc. indifference point, 2s delay0.20.20.4-0.60.50.2-0.40.20.4-0.4
Delay disc. indifference point, 24s delay0.91.02.2-1.5-1.1-1.00.9-0.6-0.90.8
Delay disc. indifference point, 4s delay0.00.00.2-0.5-0.0-0.10.1-0.3-0.10.1
Delay disc. indifference point, 8s delay0.91.11.70.51.21.0-1.11.31.0-1.1
Indifference point function ln k0.40.61.1-0.8-0.4-0.70.5-1.0-1.00.9
Indifference point function log k0.40.61.1-0.8-0.4-0.70.5-1.0-1.00.9
Patch foraging total patch changes 0 sec0.20.50.7-0.6-0.4-0.70.7-0.7-0.70.8
Patch foraging total patch changes 12 sec0.20.20.4-0.4-0.5-0.50.6-0.5-0.30.3
Patch foraging total patch changes 18 sec0.30.40.80.80.40.4-0.40.90.8-0.7
Patch foraging total patch changes 24 sec0.30.50.8-0.9-0.8-0.80.8-0.6-0.40.5
Patch foraging total patch changes 6 sec0.00.00.1-0.1-0.3-0.30.30.0-0.00.1
Patch foraging time to switch 0 sec0.81.61.91.11.21.3-1.41.41.3-1.3
Patch foraging water rate 0 sec0.30.70.91.00.70.7-0.80.90.8-0.7
Patch foraging water rate 12 sec0.61.21.5-1.2-1.1-1.20.9-0.6-1.21.2
Patch foraging water rate 18 sec0.50.71.10.50.80.8-1.00.80.9-0.9
Patch foraging water rate 24 sec0.40.61.0-0.6-0.6-0.70.6-0.7-1.01.0
Patch foraging water rate 6 sec0.10.10.2-0.5-0.2-0.30.0-0.3-0.20.2
Seeking ratio, delayed vs. immediate footshock1.11.41.9-1.4-1.2-1.31.1-1.0-1.01.0
Distance traveled before self-admin2.33.03.4-1.7-1.8-1.61.7-1.9-1.71.7
Distance traveled after self-admin2.63.23.8-1.8-1.8-1.71.9-2.0-1.61.6
Extensor digitorum longus weight0.20.81.01.01.01.0-1.00.70.9-0.8
Bone: elastic displacement0.00.00.10.10.00.2-0.20.10.3-0.3
Bone: elastic work2.53.33.7-1.8-1.9-1.91.8-1.9-1.71.7
Bone: endosteal estimation0.92.02.8-1.7-1.6-1.41.5-1.1-1.21.3
Bone: endosteal perimeter0.81.72.7-1.6-1.5-1.31.2-1.1-1.21.2
Epididymis fat weight0.00.00.10.2-0.20.00.2-0.10.1-0.1
Delta time in closed arm before/after self-admin0.00.00.1-0.30.00.2-0.20.10.1-0.1
Delta time in open arm before/after self-admin0.20.20.30.1-0.4-0.30.4-0.6-0.40.4
Diff in mean of infusions in LGA sessions0.00.00.1-0.2-0.0-0.10.20.3-0.00.0
Delay discount exponential model param0.10.10.70.8-0.10.2-0.1-0.00.1-0.0
Extinction: sum of active levers before priming2.32.62.9-1.5-1.7-1.71.7-1.4-1.61.6
Active lever presses in extinction session 60.20.20.6-0.7-0.5-0.40.5-0.5-0.30.3
Bone: final force1.62.63.1-1.6-1.5-1.81.7-1.5-1.61.6
Bone: final moment2.64.24.8-2.0-2.0-2.22.1-2.0-2.02.0
Food consumed during 24 hour testing period0.20.30.5-0.7-0.5-0.60.5-0.5-0.60.6
Glucose0.20.30.50.40.30.7-0.50.70.6-0.6
Heart weight1.01.52.1-1.0-1.4-1.51.3-1.1-1.21.3
Delay discount hyperbolic model param0.10.10.40.6-0.3-0.00.2-0.1-0.10.1
Intermittent access intake day 1-15 change0.20.50.7-0.8-0.7-0.50.5-0.5-0.80.8
Intermittent access intake escalation0.10.30.4-0.6-0.6-0.40.4-0.5-0.60.7
Intermittent access intake escalation 22.12.42.8-1.5-1.7-1.41.6-1.4-1.61.7
Intermitt. access day 1 inactive lever presses1.24.45.8-2.4-1.8-2.02.0-2.0-2.22.2
Intermitt. access day 15 inactive lever presses0.51.01.4-1.2-1.0-0.90.9-0.9-1.11.2
Intermitt. access escalation Index0.40.60.9-0.6-0.7-0.70.9-0.9-0.70.7
Intermittent access day 1 total infusions0.10.20.50.70.40.3-0.4-0.4-0.20.2
Intermittent access day 15 total infusions0.20.40.8-0.2-0.4-0.40.3-0.9-0.80.8
Intermittent access terminal intake (last 3 days)0.91.21.8-0.7-0.9-1.00.9-1.2-1.31.3
Intermittent access total infusions0.20.20.50.1-0.2-0.20.1-0.7-0.70.7
Intermittent access day 1 locomotion0.20.31.10.2-0.1-0.20.2-1.0-0.50.6
Intermittent access day 15 total locomotion0.00.00.10.3-0.10.2-0.2-0.20.0-0.0
Intermittent access total locomotion0.20.20.70.90.40.5-0.5-0.10.1-0.1
Intermittent access standard deviation1.63.44.3-2.1-1.7-1.81.8-1.7-1.91.9
Left kidney weight3.214.917.1-3.2-4.1-4.04.1-4.1-3.73.7
Right kidney weight3.214.716.3-3.5-3.9-3.94.0-4.0-3.73.7
Cocaine induced anxiety0.30.40.70.30.90.6-0.70.80.7-0.6
Post-drug Anxiety0.00.00.1-0.30.20.0-0.10.10.2-0.1
Baseline Anxiety1.41.62.0-0.9-1.4-1.31.4-1.4-1.21.2
Tail length4.818.823.4-4.8-4.6-4.54.3-3.7-4.14.1
Length with tail6.427.833.8-5.8-5.4-5.55.2-4.7-5.15.1
Length without tail1.65.17.4-2.7-2.3-2.42.2-1.9-2.12.1
Times rat made contact with spout0.40.51.11.10.60.6-0.50.70.6-0.6
Lifetime Intake0.10.10.20.40.00.1-0.1-0.5-0.40.4
Liver weight, left0.10.20.6-0.1-0.4-0.50.8-0.6-0.40.4
Liver weight, right0.00.10.1-0.2-0.4-0.20.20.2-0.20.2
Locomotor activity0.61.02.11.10.60.8-0.71.51.0-1.0
Locomotor testing distance1.22.12.71.61.41.4-1.31.61.4-1.4
Locomotor testing rearing1.12.23.41.81.31.4-1.21.41.6-1.5
Locomotion in novel chamber0.60.70.90.70.81.0-0.80.70.9-1.0
Locomotion in novel chamber post-restriction0.00.10.2-0.5-0.00.0-0.20.30.1-0.0
Fecal boli incidents, locomotor time 12.63.85.01.72.12.2-2.11.62.0-1.8
Change in fecal boli incidents, locomotor task0.00.00.00.1-0.2-0.10.1-0.1-0.0-0.1
Time >=10cm from walls, locomotor time 10.00.00.10.00.10.1-0.10.10.2-0.3
Bouts of movement, locomotor time 10.30.41.7-1.3-0.6-0.40.4-0.5-0.20.2
Total resting periods, locomotor time 10.30.31.4-1.2-0.4-0.30.2-0.5-0.10.1
Rest time, locomotor task time 10.10.10.20.30.10.4-0.3-0.10.2-0.3
Distance moved, locomotor task time 10.10.10.20.0-0.4-0.50.5-0.0-0.40.3
Vertical activity count, locomotor time 10.61.41.8-1.0-1.4-1.31.3-1.0-1.21.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.1-0.1-0.30.30.10.1-0.2
Bouts of movement, locomotor time 20.40.60.9-0.00.80.6-0.90.50.9-0.9
Total resting periods, locomotor time 20.30.60.90.10.90.6-0.90.60.9-0.9
Rest time, locomotor task time 20.40.50.7-0.4-0.6-0.60.7-0.8-0.90.8
Distance moved, locomotor task time 20.10.10.30.40.20.2-0.10.50.4-0.4
Vertical activity count, locomotor time 20.10.10.2-0.5-0.4-0.20.3-0.20.0-0.0
Light reinforcement 10.20.40.70.60.60.6-0.60.80.6-0.7
Light reinforcement 26.39.611.32.83.43.2-3.33.12.9-3.0
Bone: marrow area1.02.22.9-1.7-1.6-1.51.6-1.2-1.31.3
Bone: maximum diameter1.52.83.0-1.7-1.7-1.71.6-1.6-1.71.7
Bone: maximum force3.25.76.2-2.4-2.3-2.52.5-2.3-2.42.4
Bone: maximum moment4.37.58.1-2.7-2.7-2.82.8-2.7-2.72.7
Mean time between licks in bursts0.10.30.5-0.4-0.2-0.60.4-0.7-0.70.7
Mean num. licks in bursts0.60.91.6-0.9-1.3-1.01.0-0.7-0.90.9
Cd content in liver0.60.70.80.80.90.8-0.70.90.8-0.8
Co content in liver0.91.11.51.11.21.1-1.10.81.0-1.0
Cu content in liver1.21.41.7-1.3-1.0-1.31.1-1.3-1.21.2
Fe content in liver1.01.21.50.91.01.2-1.10.91.2-1.2
K content in liver0.70.70.9-0.7-0.9-0.90.9-0.8-0.90.9
Mg content in liver0.10.10.2-0.0-0.2-0.50.3-0.4-0.40.4
Mn content in liver0.80.91.4-0.1-0.9-1.01.1-1.2-1.01.0
Na content in liver3.13.33.7-1.6-1.9-1.81.9-1.7-1.81.8
Rb content in liver0.00.00.0-0.0-0.0-0.20.00.10.0-0.0
Se content in liver2.63.05.32.31.61.8-1.61.41.6-1.6
Sr content in liver0.30.30.50.60.70.6-0.50.50.4-0.4
Zn content in liver2.12.33.51.91.51.4-1.51.41.5-1.5
Bone: minimum diameter6.011.011.9-3.3-3.4-3.43.4-3.2-3.33.3
Time in familiar zone, hab. session 10.30.30.3-0.5-0.6-0.40.5-0.5-0.50.4
Time in novel zone, hab. session 10.10.10.20.50.40.2-0.30.40.3-0.3
Total zone transitions, hab. session 10.50.71.3-0.6-0.9-0.71.1-0.8-0.80.8
Total locomotion distance, hab. session 12.73.94.9-2.1-2.0-1.92.2-1.7-1.81.9
Locomotion velocity, hab. session 11.11.62.2-1.4-1.3-1.31.5-1.0-1.21.2
Time in familiar zone, hab. session 20.40.41.0-1.0-0.5-0.50.3-0.6-0.60.7
Time in novel zone, hab. session 20.60.61.00.90.60.6-0.61.00.8-0.8
Total zone transitions, hab. session 20.10.10.60.80.20.10.10.1-0.10.0
Total locomotion distance, hab. session 20.40.50.7-0.5-0.7-0.80.8-0.7-0.80.8
Locomotion velocity, hab. session 20.40.50.6-0.3-0.6-0.80.8-0.6-0.80.8
Novel to familiar place preference ratio1.01.11.6-1.0-1.2-1.11.3-0.7-0.90.9
Novelty place preference0.80.91.4-0.9-1.1-1.01.2-0.6-0.80.8
Time in novel zone, NPP test0.50.50.9-0.7-0.9-0.80.9-0.4-0.60.6
Total zone transitions, NPP test0.10.20.30.50.50.6-0.40.30.4-0.4
Total locomotion distance, NPP test1.52.13.0-1.7-1.4-1.41.5-1.3-1.41.4
Locomotion velocity, NPP test2.02.83.7-1.9-1.6-1.71.7-1.5-1.61.6
Intraocular pressure0.10.10.2-0.00.20.5-0.30.40.5-0.4
Delta distance traveled before/after self-admin0.20.20.3-0.10.30.4-0.40.30.6-0.6
Delta ambulatory time before/after self-admin0.00.00.1-0.3-0.1-0.20.2-0.2-0.00.0
Parametrial fat weight0.10.30.70.80.50.5-0.50.50.4-0.4
Pavlov. Cond. lever latency0.40.50.70.20.80.7-0.70.80.7-0.7
Pavlov. Cond. magazine entry latency0.20.20.30.60.50.5-0.50.10.5-0.4
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1-0.00.0-0.20.00.0
Pavlov. Cond. index score0.00.10.20.3-0.2-0.10.2-0.4-0.20.2
Pavlov. Cond. latency score0.10.10.30.1-0.4-0.30.3-0.5-0.30.3
Pavlov. Cond. lever contacts0.81.01.4-0.7-1.1-1.01.0-1.2-1.01.0
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.2-0.20.20.2-0.20.2
Pavlov. Cond. intertrial magazine entries0.10.10.40.60.30.3-0.30.30.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.3-0.3-0.20.3-0.5-0.30.3
Pavlov. Cond. response bias0.10.10.40.1-0.3-0.20.2-0.6-0.20.2
Pavlov. Cond. lever latency3.95.36.62.62.22.2-2.12.42.3-2.3
Pavlov. Cond. magazine entry latency2.12.63.9-2.0-1.4-1.51.3-1.7-1.61.6
Pavlov. Cond. change in total contacts5.58.911.5-3.4-2.8-2.92.8-3.0-3.03.0
Pavlov. Cond. index score3.64.96.9-2.6-2.1-2.12.0-2.3-2.22.2
Pavlov. Cond. latency score3.24.26.0-2.5-1.9-1.91.8-2.2-2.02.0
Pavlov. Cond. lever contacts4.35.97.6-2.8-2.4-2.32.3-2.5-2.42.4
Pavlov. Cond. magazine entry number1.41.73.41.81.11.2-1.01.41.2-1.2
Pavlov. Cond. intertrial magazine entries1.01.52.21.51.21.0-1.01.41.2-1.2
Pavlov. Cond. lever-magazine prob. diff.3.85.16.9-2.6-2.1-2.12.0-2.4-2.22.2
Pavlov. Cond. response bias5.27.08.7-3.0-2.5-2.52.5-2.8-2.72.7
Time in closed arm before self-admin0.00.00.10.20.3-0.1-0.00.1-0.10.1
Time in closed arm after self-admin0.10.10.4-0.60.40.1-0.3-0.0-0.10.1
Time in open arm before self-admin0.80.91.3-1.1-1.1-1.00.9-0.8-0.80.8
Time in open arm after self-admin1.82.03.1-0.8-1.8-1.61.6-1.4-1.21.2
Bone: periosteal estimation2.24.75.3-2.3-2.3-2.32.3-2.0-2.02.0
Bone: periosteal perimeter2.03.44.0-2.0-1.9-1.91.8-1.7-1.71.7
Bone: post-yield work0.91.42.2-1.5-1.2-1.11.1-1.1-1.01.0
Progressive ratio test 1 active lever presses0.81.02.2-0.3-0.8-0.70.7-1.5-1.31.3
Progressive ratio test 1 breakpoint1.11.32.6-0.5-1.0-0.90.8-1.6-1.41.4
Progressive ratio test 1 inactive lever presses0.81.21.9-0.9-0.8-0.80.9-1.4-1.31.3
Progressive ratio test 2 active lever presses0.10.10.10.30.20.3-0.4-0.3-0.10.1
Progressive ratio test 2 breakpoint0.10.10.10.40.20.3-0.3-0.3-0.10.1
Progressive ratio test 2 inactive lever presses0.50.81.3-1.1-0.8-0.80.6-1.1-0.91.0
Incentive Sensitization - Responses0.40.60.70.60.80.7-0.80.90.8-0.8
Incentive Sensitization - Breakpoint0.50.70.90.60.80.8-0.80.90.9-0.9
Sum of active levers in priming session hrs 5-60.00.00.10.40.2-0.20.10.20.1-0.1
Progressive ratio0.61.01.50.61.11.2-1.11.10.9-0.9
Food seeking constrained by brief footshock2.42.93.5-1.9-1.6-1.61.7-1.7-1.71.7
Seeking ratio, punishment vs. effort1.52.12.7-1.4-1.5-1.61.5-1.6-1.41.4
Retroperitoneal fat weight0.41.92.51.61.41.3-1.21.31.4-1.4
Reaction time number correct0.00.10.10.3-0.3-0.20.2-0.1-0.30.2
Reaction time mean minus median0.10.20.3-0.4-0.3-0.60.5-0.4-0.40.3
Reaction time mean minus median AUC0.10.30.7-0.5-0.4-0.80.6-0.7-0.40.3
Reaction time num false alarms0.81.11.91.41.11.2-1.00.51.0-1.0
Reaction time num false alarms AUC1.11.72.71.61.41.5-1.20.81.2-1.2
Reaction time trials correct on left0.00.10.10.3-0.3-0.20.2-0.1-0.30.2
Reaction time trials on left0.00.10.10.3-0.3-0.20.2-0.1-0.30.2
Reaction time mean0.00.10.20.30.40.2-0.20.20.2-0.3
Reaction time mean AUC0.10.20.30.50.60.4-0.40.30.4-0.5
Median of all reaction times0.30.40.50.70.70.7-0.50.50.5-0.6
Reaction time omissions0.20.30.50.70.40.6-0.60.40.6-0.6
Reaction time false alarm rate1.01.41.81.21.31.4-1.20.71.2-1.1
Reaction time premature initiation rate0.00.00.0-0.20.0-0.0-0.1-0.10.00.1
Reaction time premature initiations0.00.00.00.0-0.1-0.1-0.0-0.1-0.10.2
Std. dev. reaction times0.10.10.2-0.3-0.2-0.50.4-0.4-0.30.2
Reaction time trials completed0.00.10.10.3-0.3-0.20.2-0.1-0.30.2
Reaction time trials AUC0.00.00.20.5-0.2-0.10.0-0.0-0.20.1
Run reversals in cocaine runway, females0.20.20.20.20.50.3-0.40.30.5-0.5
Run reversals in cocaine runway, males0.90.91.51.20.90.9-1.01.00.8-0.8
Latency to leave start box in cocaine runway0.10.10.20.20.30.3-0.20.50.3-0.3
Latency to leave start box in cocaine runway, F0.30.40.60.70.70.4-0.60.80.6-0.6
Latency to leave start box in cocaine runway, M0.00.00.2-0.4-0.20.10.3-0.2-0.00.0
Std. dev. time between licks in bursts0.50.60.9-0.9-0.5-0.70.7-0.9-0.90.9
Total sessions with >9 infusions0.30.31.61.30.50.5-0.4-0.2-0.0-0.0
Short access day 1 total inactive lever presses0.60.81.3-1.1-0.5-0.80.7-0.8-1.01.0
Short access day 10 total inactive lever presses1.02.54.9-2.2-1.3-1.51.3-1.4-1.61.6
Short access day 1 total infusions0.71.01.6-0.6-1.0-1.00.9-1.3-1.01.0
Short access day 10 total infusions0.10.10.40.60.20.1-0.1-0.3-0.30.3
Short access total infusions0.10.10.50.70.20.2-0.2-0.4-0.20.2
Short access day 1 locomotion1.11.32.91.71.01.1-1.00.81.1-1.1
Short access day 10 total locomotion0.71.42.2-0.7-0.8-0.91.2-1.5-1.41.4
Short access total locomotion0.20.20.70.80.10.10.1-0.7-0.40.4
One hour access (0.3 mA shock)0.60.71.1-0.9-0.7-0.60.6-1.0-1.11.1
Compulsive drug intake2.32.84.1-1.7-1.6-1.72.0-1.5-1.51.5
One hour access (shock baseline)0.00.10.20.20.10.3-0.5-0.2-0.20.2
Social response proportion4.55.15.9-2.1-2.3-2.32.1-2.1-2.42.4
Social responses0.00.10.2-0.5-0.3-0.20.10.1-0.10.2
Social time0.30.51.5-1.2-0.7-0.60.7-0.3-0.40.4
Soleus weight0.72.12.71.21.61.5-1.41.31.6-1.6
Bone: stiffness1.62.62.9-1.6-1.4-1.61.6-1.6-1.71.7
Tibialis anterior weight0.00.00.10.3-0.00.20.1-0.20.1-0.1
Time to tail flick, vehicle, before self-admin0.10.10.30.5-0.3-0.10.1-0.1-0.20.2
Time to tail flick, vehicle, after self-admin0.30.41.3-1.2-0.6-0.50.4-0.6-0.40.4
Time to tail flick, test, before self-admin0.40.40.50.70.50.5-0.50.70.7-0.7
Time to tail flick, test, after self-admin0.10.10.10.40.40.2-0.40.10.2-0.2
Delta time to tail flick, vehicle, before/after SA0.40.30.9-0.9-0.5-0.50.5-0.6-0.50.5
Delta time to tail flick, test, before/after SA0.00.00.1-0.1-0.2-0.10.1-0.3-0.30.3
Tibia length2.05.56.2-2.3-2.5-2.52.3-2.1-2.42.4
Ambulatory time before self-admin1.52.32.6-1.6-1.6-1.41.5-1.5-1.51.5
Ambulatory time after self-admin2.73.24.3-2.1-1.8-1.71.8-1.8-1.71.7
Bone: tissue strength4.94.95.3-2.2-2.2-2.22.3-2.2-2.22.2
Total heroin consumption1.21.42.0-1.0-1.0-1.21.4-1.3-1.21.2
Bone: trabecular number0.10.10.2-0.5-0.4-0.40.2-0.3-0.30.3
Bone: trabecular spacing1.82.42.6-1.5-1.6-1.51.6-1.6-1.61.6
Bone: trabecular thickness0.10.20.30.60.40.3-0.40.40.4-0.4
Bone: trabecular tissue density2.63.84.41.92.01.9-1.82.12.0-2.0
Water consumed over 24 hours0.71.01.2-0.6-1.0-1.11.0-1.1-1.01.0
Number of responses in last shaping day0.50.50.7-0.7-0.9-0.80.6-0.6-0.80.7