Hub : Genes

Ryr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ryr1 0.1 0.07 3.9e-12 0.06 0.08 0.07 0.07 1.3e-07 4.4e-09 1.9e-08 3.3e-08
2 LHb gene expression Ryr1 0.17 0.12 7.1e-04 0.11 0.11 0.09 0.02 1.4e-03 1.7e-03 4.1e-03 1.3e-01
3 Liver mRNA stability Ryr1 0.06 0.04 8.1e-08 0.03 0.05 0.04 0.04 1.2e-04 3.2e-06 2.4e-05 1.4e-05
4 Adipose mRNA stability Ryr1 0.1 0.07 5.3e-11 0.06 0.07 0.06 0.06 4.7e-07 4.7e-08 1.8e-07 3.1e-07
5 pVTA gene expression Ryr1 0.13 0.09 6.6e-06 0.12 0.14 0.11 0.1 1.0e-05 9.9e-07 1.3e-05 3.2e-05
6 BLA mRNA stability Ryr1 0.07 0.05 4.4e-04 0.04 0.03 0.01 0.02 4.6e-03 7.6e-03 1.0e-01 1.9e-02
7 RMTg gene expression Ryr1 0.13 0.1 1.2e-03 0.09 0.02 0.07 0.01 2.7e-03 1.0e-01 5.3e-03 1.8e-01
8 Adipose gene expression Ryr1 0.67 0.19 0.0e+00 0.1 0.11 0.1 0.11 1.1e-11 1.5e-12 2.4e-11 3.6e-12
9 OFC alternative TSS NM_001419537.1 0.49 0.23 3.2e-03 0.06 0.02 0.14 0.07 1.6e-02 1.3e-01 4.4e-04 7.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.20.30.3-0.30.3-0.40.30.4-0.4-0.60.5
Area under the delay curve0.40.42.8-0.60.6-0.50.3-0.1-0.0-0.0-0.01.7
BMI with tail0.20.61.40.9-0.80.9-0.70.70.6-0.6-0.1-1.2
BMI without tail0.10.20.3-0.50.5-0.50.5-0.6-0.40.40.3-0.4
Body weight2.410.011.8-3.33.3-3.43.4-3.4-3.33.43.3-0.5
Weight adjusted by age0.20.20.30.5-0.50.5-0.50.40.3-0.4-0.5-0.2
Bone surface0.20.30.5-0.60.7-0.60.6-0.6-0.50.40.30.3
Bone volume0.20.30.5-0.60.7-0.60.6-0.6-0.50.50.30.2
Breakpoint value in progressive ratio session1.92.13.4-1.81.5-1.71.5-1.4-1.31.20.91.3
Number of licking bursts1.92.33.21.8-1.81.7-1.71.61.5-1.5-1.0-0.6
Context. condit. distance diff. score0.10.10.30.2-0.50.2-0.30.30.1-0.2-0.50.4
Locomotion velocity, session 12.12.32.71.5-1.41.5-1.61.61.6-1.6-1.61.0
Locomotion distance, session 10.91.22.6-1.11.2-1.01.1-1.0-1.01.01.6-0.5
Locomotion velocity, session 20.50.61.40.7-0.80.7-0.70.70.6-0.7-1.20.5
Locomotion distance, session 20.50.71.21.1-0.91.0-0.90.80.8-0.8-0.2-0.7
Locomotion velocity, session 30.20.30.50.6-0.70.6-0.50.40.3-0.3-0.7-0.4
Locomotion distance, session 35.35.87.1-2.42.3-2.52.5-2.6-2.72.62.5-1.3
Stereotopy head waving bouts, day 30.80.92.11.1-1.31.0-0.90.70.5-0.4-1.4-0.6
Stereotopy head waving duration, day 32.93.56.91.9-2.11.9-1.91.81.7-1.6-2.60.6
Locomotion velocity, session 70.10.10.6-0.0-0.0-0.1-0.0-0.0-0.0-0.0-0.60.8
Locomotion distance, session 70.10.10.1-0.20.2-0.30.3-0.3-0.30.30.4-0.1
Stereotopy head waving bouts, day 70.10.10.20.4-0.50.3-0.30.20.0-0.1-0.5-0.3
Stereotopy head waving duration, day 71.01.21.71.3-1.31.2-1.21.10.9-1.0-1.2-0.2
Locomotion velocity, session 83.13.75.82.2-2.42.2-2.12.01.7-1.8-1.90.0
Locomotion distance, session 80.30.40.70.8-0.90.8-0.70.70.5-0.6-0.4-0.1
Degree of sensitization distance3.43.44.91.7-1.71.7-1.81.92.0-1.9-2.21.6
Degree of sensitization stereotypy0.10.10.70.3-0.20.2-0.10.0-0.10.00.2-0.8
Conditioned locomotion0.40.52.3-0.20.1-0.30.4-0.6-0.80.80.2-1.5
Cocaine response after cond. corrected0.40.40.8-0.50.4-0.60.6-0.7-0.70.70.7-0.9
Cocaine response after cond. not corrected0.70.82.4-0.50.4-0.60.7-0.8-0.90.91.0-1.5
Cocaine response before conditioning1.51.93.3-1.00.8-1.11.2-1.4-1.61.51.5-1.8
Saline control response0.40.61.1-0.70.6-0.70.7-0.7-0.70.71.1-0.6
Bone: connectivity density0.61.01.60.8-0.70.8-0.90.91.0-1.1-1.31.1
Bone: cortical apparent density1.92.63.31.8-1.81.8-1.81.71.7-1.6-1.30.1
Bone: cortical area1.92.93.7-1.71.7-1.81.8-1.9-1.91.91.6-0.6
Bone: cortical porosity1.01.11.91.3-1.41.2-1.10.90.7-0.8-1.0-1.0
Bone: cortical porosity1.11.32.11.4-1.51.3-1.10.90.7-0.8-1.0-1.2
Bone: cortical thickness0.81.32.0-1.11.0-1.21.2-1.3-1.41.41.1-0.6
Bone: cortical thickness0.20.30.90.6-0.80.5-0.40.30.0-0.1-0.3-1.0
Bone: cortical tissue density2.33.03.92.0-1.92.0-1.91.91.8-1.8-1.50.1
Condit. Reinf. active minus inactive responses0.20.20.30.5-0.50.5-0.50.50.3-0.5-0.5-0.1
Condit. Reinf. active-inactive response ratio0.20.20.40.4-0.50.4-0.40.40.2-0.4-0.60.1
Condit. Reinf. active responses1.01.21.81.4-1.11.3-1.21.21.0-1.1-0.6-0.6
Condit. Reinf. inactive responses0.70.81.31.1-0.81.1-1.01.01.0-1.0-0.0-0.7
Incentive salience index mean0.10.10.30.2-0.10.2-0.20.1-0.0-0.10.1-0.6
Condit. Reinf. lever presses0.10.20.5-0.30.5-0.30.4-0.4-0.40.30.7-0.6
Condit. Reinf. active minus inactive responses3.94.85.7-2.32.2-2.32.3-2.4-2.42.42.1-1.1
Condit. Reinf. active-inactive response ratio2.93.04.3-1.41.3-1.51.7-1.8-1.91.92.0-2.1
Condit. Reinf. active responses4.46.17.1-2.72.6-2.72.7-2.7-2.72.72.3-0.8
Condit. Reinf. inactive responses1.61.92.8-1.71.7-1.61.5-1.4-1.31.31.00.8
Condit. Reinf. lever presses6.99.312.3-3.53.4-3.43.3-3.2-3.13.02.90.0
Condit. Reinf. lever reinforcers received5.27.48.6-2.92.7-2.92.9-2.9-2.92.92.6-1.1
Conditioned reinforcement - actives0.30.30.9-0.30.5-0.40.4-0.5-0.50.50.5-0.9
Conditioned reinforcement - inactives1.82.12.6-1.51.5-1.61.6-1.6-1.51.61.4-0.3
Conditioned locomotion1.31.52.11.5-1.41.4-1.31.20.8-1.2-1.2-1.0
Patch foraging indifference point 0 sec0.20.40.5-0.60.6-0.60.6-0.6-0.60.70.6-0.6
Patch foraging indifference point AUC0.40.40.70.8-0.60.8-0.70.60.8-0.6-0.60.1
Delay disc. indifference point, 0s delay0.60.61.1-1.01.1-0.90.8-0.7-0.60.50.80.6
Delay disc. indifference point, 16s delay1.51.52.5-1.61.6-1.51.3-1.1-1.01.00.91.1
Delay disc. indifference point, 2s delay0.70.75.5-0.60.6-0.50.20.00.1-0.1-0.42.3
Delay disc. indifference point, 24s delay1.41.42.0-1.41.4-1.31.2-1.1-0.91.01.01.0
Delay disc. indifference point, 4s delay0.10.10.2-0.40.4-0.40.3-0.2-0.20.10.30.4
Delay disc. indifference point, 8s delay1.01.03.70.5-0.60.6-0.80.91.0-1.0-1.11.9
Indifference point function ln k0.40.50.7-0.90.8-0.80.8-0.8-0.80.70.7-0.0
Indifference point function log k0.40.50.7-0.90.8-0.80.8-0.8-0.80.70.7-0.0
Patch foraging total patch changes 0 sec0.30.50.6-0.70.7-0.70.7-0.7-0.70.70.8-0.5
Patch foraging total patch changes 12 sec0.20.30.4-0.50.6-0.50.5-0.6-0.50.70.5-0.3
Patch foraging total patch changes 18 sec0.10.20.20.5-0.30.5-0.40.30.5-0.3-0.4-0.0
Patch foraging total patch changes 24 sec0.60.71.3-0.91.2-0.90.9-0.9-0.70.90.80.2
Patch foraging total patch changes 6 sec0.10.10.2-0.20.3-0.20.2-0.3-0.30.30.2-0.4
Patch foraging time to switch 0 sec1.31.93.51.2-1.31.2-1.31.31.5-1.4-1.91.4
Patch foraging water rate 0 sec0.40.60.90.9-1.00.9-0.80.80.8-0.8-0.5-0.5
Patch foraging water rate 12 sec0.81.21.6-1.21.2-1.21.2-1.1-1.31.11.2-0.1
Patch foraging water rate 18 sec0.50.71.60.6-0.80.6-0.80.90.8-1.0-0.91.3
Patch foraging water rate 24 sec0.30.50.9-0.70.4-0.70.7-0.7-0.90.70.7-0.6
Patch foraging water rate 6 sec0.10.20.3-0.50.5-0.50.4-0.3-0.30.20.20.5
Seeking ratio, delayed vs. immediate footshock1.21.31.8-1.31.2-1.31.3-1.3-1.01.31.0-0.2
Distance traveled before self-admin2.02.13.1-1.41.3-1.41.5-1.5-1.61.51.8-1.0
Distance traveled after self-admin5.35.97.5-2.62.7-2.62.6-2.5-2.42.42.7-0.3
Extensor digitorum longus weight0.20.80.90.9-0.90.9-0.90.90.9-0.9-1.00.2
Bone: elastic displacement0.10.10.20.2-0.10.2-0.20.20.2-0.4-0.30.5
Bone: elastic work1.92.53.3-1.71.6-1.71.7-1.7-1.81.71.4-0.4
Bone: endosteal estimation1.12.43.3-1.81.8-1.71.7-1.6-1.51.51.60.1
Bone: endosteal perimeter1.12.23.4-1.81.8-1.71.6-1.5-1.41.31.40.5
Epididymis fat weight0.00.00.10.2-0.10.2-0.10.20.2-0.20.3-0.1
Delta time in closed arm before/after self-admin0.50.51.0-0.81.0-0.80.8-0.7-0.60.50.60.3
Delta time in open arm before/after self-admin0.20.21.00.5-0.50.4-0.30.20.1-0.10.1-1.0
Diff in mean of infusions in LGA sessions0.10.10.2-0.50.2-0.40.4-0.3-0.40.40.40.3
Delay discount exponential model param0.40.42.60.7-0.60.5-0.40.20.0-0.1-0.1-1.6
Extinction: sum of active levers before priming1.21.22.0-1.21.4-1.21.2-1.1-1.01.11.2-0.0
Active lever presses in extinction session 60.60.61.5-0.91.0-0.80.7-0.6-0.50.50.11.2
Bone: final force1.62.63.5-1.61.6-1.71.7-1.7-1.91.81.6-0.6
Bone: final moment2.43.84.9-2.01.9-2.02.1-2.1-2.22.22.0-0.8
Food consumed during 24 hour testing period0.40.40.7-0.80.8-0.70.7-0.6-0.60.60.60.1
Glucose0.30.40.60.7-0.50.7-0.70.70.8-0.8-0.40.5
Heart weight0.50.81.3-0.80.7-0.90.9-1.0-0.91.10.6-0.7
Delay discount hyperbolic model param0.40.42.70.6-0.50.4-0.20.1-0.10.10.0-1.6
Intermittent access intake day 1-15 change1.31.32.2-1.31.5-1.21.2-1.1-0.91.01.10.4
Intermittent access intake escalation0.90.91.6-1.11.3-1.11.0-1.0-0.80.80.80.3
Intermittent access intake escalation 23.02.93.8-1.81.8-1.81.8-1.8-1.71.72.0-0.6
Intermitt. access day 1 inactive lever presses0.60.71.9-1.01.1-0.90.7-0.6-0.40.40.41.4
Intermitt. access day 15 inactive lever presses0.30.30.7-0.70.8-0.60.5-0.4-0.40.30.50.8
Intermitt. access escalation Index0.20.20.6-0.30.0-0.30.4-0.3-0.50.40.5-0.8
Intermittent access day 1 total infusions0.50.64.30.5-0.70.4-0.20.1-0.40.10.3-2.1
Intermittent access day 15 total infusions0.80.91.3-0.80.8-0.90.9-1.0-1.11.00.9-1.0
Intermittent access terminal intake (last 3 days)1.41.52.0-1.11.0-1.11.2-1.3-1.41.31.4-1.2
Intermittent access total infusions0.70.82.7-0.50.5-0.60.7-0.7-1.00.81.0-1.6
Intermittent access day 1 locomotion0.40.43.10.4-0.50.3-0.20.1-0.30.00.2-1.8
Intermittent access day 15 total locomotion0.00.00.10.2-0.20.2-0.20.20.0-0.2-0.1-0.3
Intermittent access total locomotion0.40.50.80.9-0.70.8-0.70.70.5-0.7-0.4-0.8
Intermittent access standard deviation5.05.37.7-2.62.8-2.52.5-2.4-2.32.22.20.3
Left kidney weight2.57.19.5-2.42.4-2.52.7-2.8-2.73.03.1-2.2
Right kidney weight3.810.713.8-3.43.3-3.43.5-3.5-3.33.53.7-1.3
Cocaine induced anxiety0.10.10.6-0.30.2-0.20.1-0.00.10.1-0.20.7
Post-drug Anxiety0.50.51.70.3-0.30.4-0.60.60.8-0.6-0.91.3
Baseline Anxiety0.30.31.00.6-0.70.6-0.40.40.2-0.3-0.1-1.0
Tail length4.714.218.4-4.34.2-4.24.1-4.1-3.73.83.40.4
Length with tail7.025.632.5-5.75.5-5.75.5-5.4-5.15.34.60.6
Length without tail3.47.59.0-3.02.8-3.02.9-2.9-2.93.02.70.2
Times rat made contact with spout0.50.50.90.9-0.90.9-0.70.70.5-0.6-0.3-0.8
Lifetime Intake0.30.32.10.1-0.10.00.1-0.2-0.50.30.3-1.5
Liver weight, left0.20.30.80.6-0.60.5-0.40.30.3-0.3-0.2-0.9
Liver weight, right0.00.00.10.0-0.00.00.0-0.1-0.20.2-0.0-0.3
Locomotor activity0.40.71.01.0-0.91.0-0.90.80.8-0.8-0.7-0.1
Locomotor testing distance0.81.41.71.3-1.21.3-1.31.21.2-1.2-1.30.3
Locomotor testing rearing1.52.33.21.7-1.81.7-1.61.51.5-1.4-1.70.1
Locomotion in novel chamber0.40.51.00.5-0.40.5-0.60.70.8-0.8-0.71.0
Locomotion in novel chamber post-restriction0.20.31.7-0.50.4-0.40.3-0.2-0.10.2-0.31.3
Fecal boli incidents, locomotor time 13.03.34.81.6-1.71.7-1.81.92.1-2.2-1.91.3
Change in fecal boli incidents, locomotor task0.20.20.3-0.30.2-0.40.4-0.4-0.60.50.5-0.5
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.20.1-0.10.10.2-0.2-0.00.1
Bouts of movement, locomotor time 10.91.05.0-1.11.0-1.00.7-0.6-0.20.30.22.2
Total resting periods, locomotor time 10.91.05.4-1.00.9-0.90.6-0.4-0.10.2-0.02.3
Rest time, locomotor task time 10.00.10.10.2-0.20.2-0.20.30.3-0.4-0.1-0.0
Distance moved, locomotor task time 10.20.20.9-0.00.0-0.10.2-0.3-0.50.60.1-0.9
Vertical activity count, locomotor time 11.01.01.4-1.00.9-1.01.1-1.1-1.21.20.8-0.7
Time >=10cm from walls, locomotor time 20.10.10.20.1-0.10.00.1-0.1-0.10.30.5-0.5
Bouts of movement, locomotor time 20.70.84.90.0-0.00.1-0.30.40.7-0.5-0.92.2
Total resting periods, locomotor time 20.60.63.60.1-0.20.2-0.40.50.7-0.5-0.91.9
Rest time, locomotor task time 20.30.30.7-0.30.3-0.40.5-0.5-0.70.50.7-0.8
Distance moved, locomotor task time 20.10.10.20.4-0.30.3-0.30.20.2-0.1-0.2-0.4
Vertical activity count, locomotor time 20.20.20.4-0.50.6-0.50.4-0.4-0.20.30.10.6
Light reinforcement 10.20.30.60.5-0.30.6-0.60.50.8-0.6-0.40.5
Light reinforcement 26.48.510.42.9-2.93.0-3.03.13.1-3.2-3.21.6
Bone: marrow area1.22.53.4-1.81.8-1.81.7-1.7-1.51.51.60.1
Bone: maximum diameter1.22.32.7-1.61.6-1.61.6-1.6-1.61.61.4-0.3
Bone: maximum force2.84.75.9-2.32.2-2.32.3-2.3-2.42.32.3-0.6
Bone: maximum moment3.66.27.5-2.62.5-2.62.6-2.6-2.72.72.6-0.8
Mean time between licks in bursts0.10.20.3-0.30.1-0.40.4-0.4-0.60.60.3-0.3
Mean num. licks in bursts0.60.71.0-0.91.0-1.01.0-1.0-0.90.90.6-0.0
Cd content in liver0.30.30.40.5-0.40.5-0.50.60.6-0.6-0.50.5
Co content in liver1.72.02.31.5-1.51.5-1.51.51.4-1.5-1.50.4
Cu content in liver1.11.31.7-1.11.1-1.11.2-1.2-1.11.31.2-0.9
Fe content in liver0.30.40.80.4-0.30.5-0.60.70.7-0.7-0.50.9
K content in liver0.60.61.1-0.60.5-0.60.7-0.8-0.70.90.8-1.0
Mg content in liver0.20.21.20.2-0.30.10.0-0.2-0.20.30.1-1.1
Mn content in liver1.01.17.10.0-0.2-0.20.4-0.6-0.80.90.9-2.7
Na content in liver4.85.15.9-2.22.2-2.32.4-2.4-2.42.42.4-1.3
Rb content in liver0.00.00.1-0.10.1-0.10.0-0.00.00.1-0.20.3
Se content in liver3.74.66.82.6-2.62.5-2.32.11.9-2.0-1.6-1.4
Sr content in liver0.70.71.00.9-1.00.9-0.90.80.7-0.8-0.8-0.4
Zn content in liver0.30.30.40.6-0.60.6-0.60.60.6-0.6-0.60.0
Bone: minimum diameter5.19.611.2-3.33.2-3.33.3-3.3-3.33.33.1-0.9
Time in familiar zone, hab. session 10.30.30.5-0.50.7-0.50.5-0.5-0.50.40.5-0.1
Time in novel zone, hab. session 10.20.10.40.4-0.60.4-0.40.30.3-0.2-0.4-0.2
Total zone transitions, hab. session 10.60.92.6-0.70.9-0.70.8-0.8-0.80.81.6-1.0
Total locomotion distance, hab. session 13.14.46.8-2.22.4-2.22.2-2.1-2.02.02.6-0.4
Locomotion velocity, hab. session 11.42.03.8-1.51.7-1.41.4-1.3-1.31.31.9-0.2
Time in familiar zone, hab. session 20.70.71.8-1.01.0-1.00.8-0.7-0.70.5-0.11.3
Time in novel zone, hab. session 20.60.60.90.9-0.90.9-0.80.80.9-0.7-0.2-0.5
Total zone transitions, hab. session 20.40.63.20.7-0.60.6-0.40.3-0.0-0.00.6-1.8
Total locomotion distance, hab. session 20.50.61.3-0.60.6-0.60.7-0.7-0.90.81.1-0.8
Locomotion velocity, hab. session 20.40.61.2-0.40.5-0.50.6-0.6-0.90.81.1-1.1
Novel to familiar place preference ratio1.11.12.0-1.01.2-1.01.1-1.1-0.91.01.4-0.6
Novelty place preference1.01.02.0-0.91.1-1.01.0-1.0-0.90.91.4-0.7
Time in novel zone, NPP test0.60.61.3-0.70.8-0.70.8-0.8-0.70.71.1-0.6
Total zone transitions, NPP test0.10.10.20.4-0.20.5-0.40.50.4-0.50.10.1
Total locomotion distance, NPP test1.82.43.4-1.81.8-1.71.6-1.5-1.51.51.60.4
Locomotion velocity, NPP test2.23.14.2-2.02.1-1.91.9-1.8-1.81.71.90.2
Intraocular pressure0.10.10.7-0.00.10.1-0.10.20.3-0.50.40.8
Delta distance traveled before/after self-admin0.91.02.7-1.21.3-1.10.9-0.8-0.50.60.41.6
Delta ambulatory time before/after self-admin1.11.21.9-1.31.4-1.31.2-1.1-0.91.00.90.5
Parametrial fat weight0.61.31.81.3-1.31.3-1.21.11.0-1.0-1.1-0.7
Pavlov. Cond. lever latency0.30.42.20.1-0.20.2-0.30.40.5-0.4-0.81.5
Pavlov. Cond. magazine entry latency0.10.10.20.3-0.30.4-0.30.40.3-0.4-0.1-0.1
Pavlov. Cond. change in total contacts0.00.00.20.00.00.00.00.0-0.0-0.00.4-0.5
Pavlov. Cond. index score0.20.21.40.2-0.20.2-0.0-0.0-0.10.10.4-1.2
Pavlov. Cond. latency score0.10.21.30.0-0.0-0.00.1-0.2-0.30.20.5-1.1
Pavlov. Cond. lever contacts0.70.91.3-0.70.8-0.80.9-0.9-1.00.91.1-1.1
Pavlov. Cond. magazine entry number0.10.10.2-0.30.3-0.30.3-0.2-0.10.2-0.10.5
Pavlov. Cond. intertrial magazine entries0.20.20.50.6-0.60.5-0.50.40.4-0.3-0.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.30.32.30.1-0.10.00.1-0.2-0.40.30.7-1.5
Pavlov. Cond. response bias0.10.20.6-0.20.2-0.20.3-0.3-0.40.30.6-0.8
Pavlov. Cond. lever latency3.24.35.92.4-2.42.4-2.32.22.1-2.0-1.9-0.3
Pavlov. Cond. magazine entry latency1.82.13.2-1.71.8-1.71.5-1.4-1.31.31.20.6
Pavlov. Cond. change in total contacts6.18.511.4-3.43.3-3.33.2-3.0-3.02.92.50.3
Pavlov. Cond. index score3.03.85.7-2.32.4-2.22.1-2.0-1.91.81.70.6
Pavlov. Cond. latency score2.83.55.3-2.22.3-2.12.0-1.9-1.81.71.60.6
Pavlov. Cond. lever contacts3.14.25.7-2.42.4-2.32.2-2.1-2.02.01.90.3
Pavlov. Cond. magazine entry number1.41.73.11.6-1.81.5-1.41.21.0-1.0-1.1-1.1
Pavlov. Cond. intertrial magazine entries1.01.22.11.4-1.51.3-1.21.10.9-0.9-0.6-0.9
Pavlov. Cond. lever-magazine prob. diff.3.34.26.1-2.42.5-2.32.2-2.1-2.01.91.90.4
Pavlov. Cond. response bias3.54.86.4-2.52.5-2.52.4-2.2-2.22.12.10.2
Time in closed arm before self-admin0.20.21.00.4-0.80.3-0.30.2-0.1-0.0-0.0-1.0
Time in closed arm after self-admin0.20.20.4-0.60.3-0.60.5-0.4-0.50.40.4-0.0
Time in open arm before self-admin1.21.21.9-1.21.4-1.21.2-1.2-1.11.11.00.0
Time in open arm after self-admin0.80.81.2-0.60.8-0.70.9-1.0-1.01.11.1-1.0
Bone: periosteal estimation1.93.94.6-2.12.1-2.12.1-2.1-2.12.01.9-0.2
Bone: periosteal perimeter1.72.93.7-1.91.9-1.91.8-1.8-1.71.71.60.2
Bone: post-yield work0.81.11.7-1.31.3-1.21.1-1.0-1.01.01.00.5
Progressive ratio test 1 active lever presses1.61.73.0-1.10.7-1.21.2-1.3-1.61.31.3-1.7
Progressive ratio test 1 breakpoint2.02.12.8-1.31.0-1.41.4-1.5-1.71.61.4-1.5
Progressive ratio test 1 inactive lever presses0.40.40.7-0.80.9-0.70.7-0.6-0.50.50.50.4
Progressive ratio test 2 active lever presses0.60.60.8-0.80.8-0.80.8-0.8-0.90.80.9-0.7
Progressive ratio test 2 breakpoint0.70.81.3-0.80.8-0.80.8-0.8-0.90.81.2-1.1
Progressive ratio test 2 inactive lever presses2.83.34.5-2.12.1-2.01.9-1.8-1.71.71.80.3
Incentive Sensitization - Responses0.10.10.4-0.20.3-0.10.10.00.2-0.00.20.6
Incentive Sensitization - Breakpoint0.10.10.60.00.20.1-0.10.20.4-0.2-0.00.8
Sum of active levers in priming session hrs 5-60.10.00.2-0.1-0.0-0.10.1-0.2-0.20.30.10.4
Progressive ratio0.40.40.90.5-0.20.5-0.60.70.7-1.0-0.60.8
Food seeking constrained by brief footshock3.03.74.5-2.12.1-2.12.0-2.0-2.01.92.0-0.4
Seeking ratio, punishment vs. effort1.82.23.4-1.51.2-1.51.6-1.6-1.61.81.5-0.8
Retroperitoneal fat weight1.03.45.12.3-2.02.2-2.01.91.9-1.8-1.1-0.6
Reaction time number correct0.20.21.70.2-0.30.10.0-0.2-0.30.20.0-1.3
Reaction time mean minus median0.20.30.4-0.50.4-0.50.5-0.5-0.70.70.7-0.4
Reaction time mean minus median AUC0.30.40.7-0.60.4-0.60.6-0.6-0.70.90.7-0.6
Reaction time num false alarms0.91.21.71.3-1.31.2-1.21.21.0-1.2-0.9-0.2
Reaction time num false alarms AUC1.21.72.31.5-1.51.5-1.41.41.2-1.4-1.0-0.2
Reaction time trials correct on left0.20.21.70.2-0.30.10.0-0.2-0.30.20.0-1.3
Reaction time trials on left0.20.21.80.2-0.30.10.0-0.2-0.30.2-0.0-1.3
Reaction time mean0.10.10.40.3-0.40.3-0.20.30.1-0.20.3-0.7
Reaction time mean AUC0.20.20.60.5-0.60.5-0.40.50.3-0.40.1-0.8
Median of all reaction times0.20.30.50.5-0.60.5-0.50.50.4-0.50.1-0.7
Reaction time omissions0.20.30.80.6-0.90.5-0.50.50.3-0.4-0.6-0.4
Reaction time false alarm rate1.01.41.81.2-1.11.2-1.21.31.3-1.4-0.90.7
Reaction time premature initiation rate0.10.10.9-0.20.3-0.20.1-0.1-0.10.0-0.11.0
Reaction time premature initiations0.00.00.1-0.10.0-0.10.1-0.1-0.20.1-0.20.2
Std. dev. reaction times0.10.20.4-0.30.1-0.30.4-0.4-0.60.50.7-0.6
Reaction time trials completed0.20.21.80.2-0.30.10.0-0.2-0.30.2-0.0-1.3
Reaction time trials AUC0.20.32.20.4-0.50.3-0.1-0.0-0.20.1-0.2-1.5
Run reversals in cocaine runway, females0.30.30.60.4-0.30.4-0.50.60.6-0.6-0.60.8
Run reversals in cocaine runway, males1.21.12.11.2-1.51.1-1.11.00.8-0.9-1.3-0.5
Latency to leave start box in cocaine runway0.10.10.40.2-0.20.2-0.30.20.3-0.3-0.50.7
Latency to leave start box in cocaine runway, F0.50.61.20.7-0.80.7-0.70.70.7-0.6-1.10.7
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.4-0.30.3-0.2-0.2-0.00.50.4
Std. dev. time between licks in bursts0.60.71.1-1.00.9-1.00.9-0.9-0.80.80.30.7
Total sessions with >9 infusions0.80.95.90.7-0.90.6-0.40.2-0.2-0.10.1-2.4
Short access day 1 total inactive lever presses0.60.71.2-1.01.1-0.90.8-0.7-0.60.60.50.9
Short access day 10 total inactive lever presses0.50.51.4-0.91.0-0.80.6-0.5-0.40.30.21.2
Short access day 1 total infusions0.30.41.5-0.30.0-0.40.4-0.6-0.70.70.3-1.2
Short access day 10 total infusions0.30.31.40.6-0.60.5-0.40.4-0.0-0.20.0-1.2
Short access total infusions0.50.52.50.8-0.80.7-0.50.40.1-0.3-0.1-1.6
Short access day 1 locomotion1.61.72.61.6-1.51.5-1.41.31.3-1.3-1.2-0.6
Short access day 10 total locomotion0.40.51.2-0.50.7-0.50.6-0.6-0.70.51.0-1.1
Short access total locomotion0.60.63.30.8-0.70.7-0.60.50.3-0.40.1-1.8
One hour access (0.3 mA shock)1.41.62.2-1.41.5-1.41.3-1.2-1.41.11.3-0.4
Compulsive drug intake0.30.30.5-0.70.7-0.70.6-0.6-0.50.50.30.3
One hour access (shock baseline)0.20.20.3-0.40.4-0.40.4-0.4-0.60.40.4-0.5
Social response proportion4.14.56.5-2.21.8-2.22.2-2.3-2.62.31.8-1.4
Social responses0.10.10.3-0.50.3-0.40.4-0.3-0.30.2-0.10.6
Social time0.70.91.7-1.21.2-1.11.0-0.8-0.50.50.71.3
Soleus weight0.72.22.91.3-1.31.4-1.51.61.5-1.7-1.61.4
Bone: stiffness1.42.23.0-1.61.5-1.61.6-1.6-1.71.61.5-0.4
Tibialis anterior weight0.00.00.30.1-0.10.1-0.00.00.0-0.00.3-0.6
Time to tail flick, vehicle, before self-admin0.40.42.80.3-0.10.20.0-0.2-0.40.40.3-1.7
Time to tail flick, vehicle, after self-admin0.20.20.5-0.70.4-0.60.6-0.5-0.60.30.30.2
Time to tail flick, test, before self-admin0.20.20.90.3-0.40.2-0.1-0.1-0.30.3-0.0-1.0
Time to tail flick, test, after self-admin0.20.21.60.2-0.30.2-0.1-0.0-0.10.20.0-1.3
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.60.4-0.60.5-0.4-0.30.20.20.6
Delta time to tail flick, test, before/after SA0.10.10.40.2-0.10.2-0.10.10.1-0.00.1-0.7
Tibia length1.85.16.1-2.32.2-2.42.4-2.4-2.52.42.3-0.8
Ambulatory time before self-admin1.11.22.0-1.11.0-1.11.1-1.1-1.21.11.4-0.6
Ambulatory time after self-admin5.86.48.0-2.82.8-2.82.7-2.6-2.52.52.70.1
Bone: tissue strength4.24.14.8-2.12.1-2.12.2-2.1-2.12.12.2-0.7
Total heroin consumption1.72.03.7-1.41.4-1.41.4-1.4-1.31.41.9-0.5
Bone: trabecular number0.10.10.2-0.40.4-0.40.3-0.3-0.30.20.10.2
Bone: trabecular spacing1.72.22.6-1.51.4-1.51.5-1.5-1.61.61.6-0.6
Bone: trabecular thickness0.30.30.50.7-0.70.6-0.60.50.5-0.4-0.5-0.5
Bone: trabecular tissue density2.43.43.92.0-1.92.0-2.01.92.0-1.9-1.90.6
Water consumed over 24 hours0.70.91.7-0.70.6-0.80.9-1.0-1.11.01.1-1.3
Number of responses in last shaping day2.02.12.9-1.41.1-1.51.5-1.6-1.71.61.6-0.8