Hub : Genes

Rxfp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Rxfp2 0.16 0.07 1.2e-15 0.09 0.17 0.15 0.16 2.1e-08 1.9e-15 4.5e-14 1.1e-14
2 IC gene expression Rxfp2 0.36 0.12 5.9e-11 0.27 0.27 0.28 0.3 7.5e-12 8.3e-12 2.2e-12 7.1e-13
3 NAcc gene expression Rxfp2 0.06 0.04 1.9e-08 0.06 0.05 0.05 0.06 9.0e-09 3.4e-08 2.0e-08 7.5e-09
4 Brain intron excision ratio chr12_9982411_9987014 0.11 0.07 1.6e-03 0.04 0.04 0.03 0.04 1.5e-04 2.7e-04 7.5e-04 2.3e-04
5 Brain intron excision ratio chr12_9982411_9987125 0.11 0.07 8.1e-04 0.05 0.04 0.04 0.04 2.0e-05 1.2e-04 1.3e-04 7.0e-05
6 LHb gene expression Rxfp2 0.3 0.13 7.6e-06 0.24 0.25 0.26 0.26 1.6e-06 1.3e-06 5.5e-07 5.2e-07
7 OFC gene expression Rxfp2 0.68 0.11 1.8e-07 0.2 0.27 0.22 0.23 2.2e-05 3.9e-07 6.5e-06 2.7e-06
8 OFC mRNA stability Rxfp2 0.26 0.13 5.6e-04 0.01 0.08 0.02 0.07 2.2e-01 7.2e-03 9.8e-02 7.7e-03
9 Brain mRNA stability Rxfp2 0.09 0.05 1.8e-07 0.06 0.07 0.05 0.06 1.5e-06 9.5e-07 1.3e-05 2.6e-06
10 PL mRNA stability Rxfp2 0.08 0.05 4.0e-05 0.06 0.03 0.02 0.05 6.5e-07 2.5e-04 2.7e-03 5.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density7.112.219.8-3.9-4.3-4.2-4.24.2-4.4-2.6-0.9-0.02.7
Area under the delay curve0.81.02.21.31.41.50.8-0.81.20.60.60.4-0.5
BMI with tail3.110.618.3-3.3-4.3-4.2-3.83.8-4.1-2.0-0.20.72.8
BMI without tail1.75.313.1-3.3-3.6-3.1-1.21.2-1.6-2.2-2.4-1.60.3
Body weight10.646.381.2-8.9-9.0-8.6-7.17.1-7.6-6.0-4.2-2.63.0
Weight adjusted by age1.32.05.9-1.7-1.3-1.1-1.21.2-0.8-2.4-1.8-1.30.1
Bone surface6.411.618.0-4.1-4.2-4.0-4.04.0-4.2-2.8-1.4-0.52.4
Bone volume6.010.818.6-3.2-3.9-3.9-4.24.2-4.3-2.0-0.10.63.0
Breakpoint value in progressive ratio session0.10.20.4-0.2-0.4-0.20.6-0.60.5-0.0-0.5-0.5-0.0
Number of licking bursts1.52.47.0-1.50.30.5-0.90.9-0.1-1.9-2.4-2.7-1.8
Context. condit. distance diff. score2.53.07.0-1.8-2.6-2.7-1.61.6-2.1-0.00.00.51.7
Locomotion velocity, session 10.91.02.60.60.71.01.6-1.61.1-0.6-0.5-0.4-0.8
Locomotion distance, session 10.70.92.10.91.31.40.9-0.91.2-0.9-0.3-0.0-0.7
Locomotion velocity, session 21.61.95.00.21.31.70.6-0.61.2-1.5-1.5-1.6-2.2
Locomotion distance, session 21.92.75.20.31.92.30.9-0.91.4-2.1-1.8-1.7-2.0
Locomotion velocity, session 30.30.40.8-0.3-0.5-0.6-0.90.9-0.60.00.40.50.6
Locomotion distance, session 30.00.00.1-0.0-0.0-0.2-0.20.20.1-0.00.10.30.1
Stereotopy head waving bouts, day 31.01.12.4-1.6-1.5-1.00.1-0.1-0.5-1.3-1.5-1.10.1
Stereotopy head waving duration, day 30.00.10.20.1-0.20.00.3-0.30.2-0.2-0.00.10.5
Locomotion velocity, session 70.50.51.31.01.21.10.0-0.00.40.60.80.70.5
Locomotion distance, session 70.20.20.70.50.80.70.1-0.10.10.50.50.40.5
Stereotopy head waving bouts, day 71.71.94.61.21.61.61.7-1.72.10.5-0.3-0.4-1.3
Stereotopy head waving duration, day 71.61.93.81.41.81.81.5-1.51.90.5-0.0-0.3-1.5
Locomotion velocity, session 80.30.30.90.10.10.30.6-0.60.7-0.2-0.6-0.5-1.0
Locomotion distance, session 80.91.32.8-1.5-1.3-1.0-1.01.0-1.2-1.7-1.2-0.70.1
Degree of sensitization distance0.70.72.10.91.31.40.9-0.90.80.20.0-0.2-0.5
Degree of sensitization stereotypy1.81.93.61.61.71.61.5-1.51.91.30.50.2-1.0
Conditioned locomotion0.81.02.8-0.7-1.7-1.6-0.20.2-0.5-0.90.00.71.6
Cocaine response after cond. corrected0.91.13.40.8-0.1-0.30.5-0.50.11.81.51.41.2
Cocaine response after cond. not corrected1.31.53.70.9-0.3-0.50.6-0.60.11.91.81.91.6
Cocaine response before conditioning0.20.20.6-0.2-0.6-0.6-0.30.3-0.5-0.20.30.60.8
Saline control response2.12.88.4-2.1-1.2-0.7-0.10.1-0.2-2.1-2.9-2.6-1.5
Bone: connectivity density8.212.920.7-4.5-4.5-4.1-3.93.9-4.2-3.4-2.1-1.12.2
Bone: cortical apparent density0.20.20.70.60.40.3-0.10.1-0.10.60.80.60.4
Bone: cortical area2.13.25.7-2.1-2.1-2.2-2.22.2-2.4-1.2-0.5-0.11.1
Bone: cortical porosity1.21.32.50.71.21.21.6-1.61.40.5-0.3-0.4-1.4
Bone: cortical porosity1.31.42.61.01.41.41.6-1.61.50.60.0-0.2-1.1
Bone: cortical thickness1.72.74.7-2.0-2.1-2.1-2.02.0-2.2-1.0-0.4-0.11.0
Bone: cortical thickness0.30.40.9-1.0-0.9-0.8-0.20.2-0.3-0.2-0.7-0.60.4
Bone: cortical tissue density0.20.20.60.60.50.30.0-0.00.00.60.80.50.3
Condit. Reinf. active minus inactive responses0.91.02.2-0.4-0.5-0.5-1.51.5-1.3-1.30.20.41.0
Condit. Reinf. active-inactive response ratio0.80.81.9-0.2-0.4-0.5-1.41.4-1.2-0.50.60.61.2
Condit. Reinf. active responses0.10.10.6-0.2-0.2-0.2-0.50.5-0.3-0.8-0.10.10.1
Condit. Reinf. inactive responses0.70.92.20.70.80.81.2-1.21.50.4-0.1-0.2-1.3
Incentive salience index mean0.40.50.9-0.2-0.6-0.6-0.70.7-0.8-0.70.40.71.0
Condit. Reinf. lever presses0.30.51.50.5-0.5-0.40.4-0.40.10.71.01.20.8
Condit. Reinf. active minus inactive responses0.70.92.3-0.60.20.40.6-0.60.6-0.7-1.5-1.5-1.5
Condit. Reinf. active-inactive response ratio1.01.22.00.00.81.01.1-1.11.2-0.8-1.4-1.4-1.3
Condit. Reinf. active responses0.50.72.1-1.0-0.4-0.2-0.10.1-0.1-1.1-1.5-1.3-1.0
Condit. Reinf. inactive responses0.50.61.2-1.0-1.0-1.0-0.80.8-1.1-0.5-0.3-0.10.1
Condit. Reinf. lever presses0.71.01.9-0.9-1.2-1.4-1.11.1-1.1-0.80.00.51.0
Condit. Reinf. lever reinforcers received0.50.82.1-0.9-0.10.0-0.20.2-0.1-1.3-1.4-1.3-1.1
Conditioned reinforcement - actives0.61.12.5-1.5-1.6-1.40.2-0.2-0.4-0.5-1.4-1.2-0.2
Conditioned reinforcement - inactives0.40.52.50.40.80.70.3-0.30.71.60.2-0.3-0.9
Conditioned locomotion0.50.71.7-1.0-1.1-0.80.3-0.3-0.1-0.3-1.3-1.2-0.8
Patch foraging indifference point 0 sec1.93.67.0-1.5-2.0-2.0-2.62.6-2.3-1.30.30.82.0
Patch foraging indifference point AUC0.81.22.5-1.6-1.3-1.2-1.11.1-1.0-1.2-1.0-0.70.3
Delay disc. indifference point, 0s delay0.10.10.30.10.50.4-0.50.5-0.3-0.50.10.10.1
Delay disc. indifference point, 16s delay0.60.71.31.01.11.00.3-0.30.91.10.90.7-0.3
Delay disc. indifference point, 2s delay1.61.83.71.91.81.71.2-1.21.00.81.31.20.3
Delay disc. indifference point, 24s delay1.31.53.81.41.91.90.6-0.61.70.80.40.1-1.0
Delay disc. indifference point, 4s delay0.90.91.71.31.00.90.8-0.80.70.71.21.20.4
Delay disc. indifference point, 8s delay0.10.10.40.40.50.60.3-0.30.4-0.10.0-0.0-0.3
Indifference point function ln k0.10.20.6-0.4-0.0-0.0-0.00.0-0.2-0.5-0.6-0.7-0.8
Indifference point function log k0.10.20.6-0.4-0.0-0.0-0.00.0-0.2-0.5-0.6-0.7-0.8
Patch foraging total patch changes 0 sec2.13.96.8-1.6-2.2-2.2-2.62.6-2.4-1.30.20.92.1
Patch foraging total patch changes 12 sec3.64.78.4-1.8-2.4-2.4-2.92.9-2.6-1.20.41.12.4
Patch foraging total patch changes 18 sec0.91.42.6-0.9-1.3-1.4-1.61.6-1.3-0.30.30.71.4
Patch foraging total patch changes 24 sec1.22.14.1-1.2-2.0-2.0-1.71.7-1.5-1.00.00.61.5
Patch foraging total patch changes 6 sec1.52.34.0-1.4-2.0-1.9-1.81.8-1.6-0.80.10.61.6
Patch foraging time to switch 0 sec1.73.56.62.61.91.51.6-1.61.32.22.32.10.9
Patch foraging water rate 0 sec2.65.510.5-3.2-3.0-2.7-2.32.3-2.1-2.3-2.2-1.8-0.1
Patch foraging water rate 12 sec0.91.93.8-1.5-0.7-0.5-1.01.0-0.6-2.0-1.9-1.9-1.4
Patch foraging water rate 18 sec0.50.82.2-0.10.00.30.8-0.80.9-0.8-1.2-1.2-1.5
Patch foraging water rate 24 sec2.43.47.8-2.4-1.7-1.4-0.60.6-0.7-2.6-2.8-2.5-1.2
Patch foraging water rate 6 sec1.11.72.6-1.6-1.3-1.2-1.51.5-1.6-1.5-1.0-0.8-0.2
Seeking ratio, delayed vs. immediate footshock1.11.42.41.51.21.21.4-1.41.11.31.10.9-0.0
Distance traveled before self-admin0.71.02.11.21.11.00.1-0.10.21.41.41.20.4
Distance traveled after self-admin0.10.10.3-0.2-0.10.0-0.50.50.0-0.1-0.00.00.0
Extensor digitorum longus weight2.39.019.4-4.2-4.1-4.4-3.03.0-3.2-1.2-1.6-1.11.4
Bone: elastic displacement1.01.22.80.10.91.01.3-1.31.40.1-1.0-1.1-1.7
Bone: elastic work2.22.96.7-2.6-1.9-1.7-1.21.2-1.2-1.9-2.1-1.8-0.4
Bone: endosteal estimation0.71.63.2-1.8-0.9-1.0-1.11.1-0.8-1.6-1.7-1.6-0.7
Bone: endosteal perimeter1.22.74.2-2.0-1.9-2.0-1.91.9-2.0-1.3-0.9-0.60.8
Epididymis fat weight1.03.57.8-1.4-2.0-1.9-2.52.5-2.8-0.70.60.81.9
Delta time in closed arm before/after self-admin0.20.20.6-0.50.10.3-0.50.5-0.5-0.2-0.6-0.8-0.4
Delta time in open arm before/after self-admin3.83.86.92.61.91.52.1-2.12.22.01.91.80.1
Diff in mean of infusions in LGA sessions0.10.10.6-0.1-0.1-0.4-0.10.10.10.80.10.0-0.1
Delay discount exponential model param1.31.53.1-1.6-1.7-1.8-1.11.1-1.5-0.9-0.8-0.50.7
Extinction: sum of active levers before priming0.91.02.5-0.5-1.0-0.9-1.61.6-1.0-0.50.30.61.2
Active lever presses in extinction session 61.51.52.7-1.3-1.5-1.4-1.71.7-1.5-0.8-0.3-0.20.7
Bone: final force1.62.55.0-2.2-2.0-1.8-1.41.4-1.2-1.7-1.7-1.40.0
Bone: final moment1.42.24.3-2.1-1.8-1.6-1.31.3-1.1-1.6-1.6-1.3-0.2
Food consumed during 24 hour testing period0.60.92.70.30.40.41.7-1.71.20.6-0.6-0.6-0.8
Glucose0.71.12.41.61.41.20.4-0.40.71.11.20.8-0.7
Heart weight0.71.01.9-1.2-0.6-0.5-0.80.8-0.6-1.2-1.4-1.4-1.1
Delay discount hyperbolic model param1.11.32.5-1.5-1.5-1.6-1.01.0-1.3-0.8-0.8-0.60.5
Intermittent access intake day 1-15 change0.20.30.7-0.9-0.7-0.5-0.50.5-0.3-0.6-0.7-0.5-0.1
Intermittent access intake escalation0.10.20.5-0.7-0.5-0.4-0.60.6-0.4-0.4-0.5-0.4-0.1
Intermittent access intake escalation 20.00.00.10.1-0.00.1-0.30.3-0.1-0.20.10.10.2
Intermitt. access day 1 inactive lever presses0.10.20.5-0.30.50.30.1-0.10.50.1-0.5-0.7-0.7
Intermitt. access day 15 inactive lever presses0.81.75.71.40.70.30.2-0.20.52.42.01.80.8
Intermitt. access escalation Index0.00.10.2-0.10.20.2-0.10.1-0.2-0.5-0.3-0.4-0.3
Intermittent access day 1 total infusions1.21.94.71.31.31.32.2-2.21.61.00.1-0.0-0.8
Intermittent access day 15 total infusions0.40.71.80.50.80.91.3-1.30.80.5-0.3-0.3-0.7
Intermittent access terminal intake (last 3 days)0.70.92.40.90.91.01.5-1.50.90.90.20.1-0.5
Intermittent access total infusions1.21.43.31.21.21.21.8-1.81.21.10.30.2-0.6
Intermittent access day 1 locomotion1.01.32.71.41.31.21.6-1.61.10.90.50.3-0.5
Intermittent access day 15 total locomotion0.81.53.10.71.01.21.7-1.71.80.8-0.6-0.8-1.3
Intermittent access total locomotion1.01.22.51.11.21.11.6-1.61.40.80.20.1-0.5
Intermittent access standard deviation0.10.10.30.40.30.30.3-0.30.40.50.30.2-0.2
Left kidney weight7.434.660.2-7.8-7.6-7.3-6.56.5-6.7-4.7-3.6-2.42.1
Right kidney weight6.027.347.9-6.9-6.3-6.1-6.06.0-6.0-4.3-3.6-2.71.2
Cocaine induced anxiety0.30.40.80.3-0.6-0.60.7-0.70.10.50.70.90.8
Post-drug Anxiety2.93.15.82.41.20.92.0-2.01.21.82.32.21.1
Baseline Anxiety2.73.17.72.52.82.21.2-1.21.31.81.81.1-0.4
Tail length3.915.132.7-5.7-4.8-4.1-1.71.7-2.2-4.3-5.3-4.5-1.0
Length with tail8.637.679.1-8.9-7.8-7.3-5.25.2-5.7-6.0-6.1-4.80.6
Length without tail9.430.248.1-6.9-6.6-6.5-6.66.6-6.6-4.6-2.8-1.62.5
Times rat made contact with spout1.51.75.6-1.10.00.10.3-0.30.3-1.4-2.2-2.4-1.8
Lifetime Intake1.31.63.61.41.21.11.9-1.91.11.30.70.5-0.2
Liver weight, left4.67.613.0-3.6-3.1-3.2-3.33.3-3.3-2.5-1.7-1.10.6
Liver weight, right3.96.911.0-3.3-3.1-3.0-2.92.9-2.7-3.1-1.9-1.10.5
Locomotor activity1.11.83.5-1.8-1.1-0.7-0.80.8-0.4-1.1-1.8-1.9-1.8
Locomotor testing distance0.51.01.8-1.3-0.9-0.7-1.11.1-0.6-0.6-1.0-1.1-1.1
Locomotor testing rearing0.10.10.50.00.10.2-0.70.70.0-0.10.10.1-0.3
Locomotion in novel chamber2.93.78.5-1.0-0.20.51.8-1.81.5-1.5-2.9-2.9-2.8
Locomotion in novel chamber post-restriction2.03.39.6-1.4-0.30.11.3-1.31.0-1.5-3.0-3.1-2.4
Fecal boli incidents, locomotor time 10.70.91.9-1.4-0.8-0.6-0.60.6-0.8-1.3-1.4-1.2-0.3
Change in fecal boli incidents, locomotor task0.60.61.60.80.60.50.8-0.80.91.30.70.4-0.6
Time >=10cm from walls, locomotor time 10.80.82.70.90.50.30.2-0.2-0.50.61.31.31.6
Bouts of movement, locomotor time 10.91.02.0-1.4-1.3-1.1-0.90.9-0.3-0.6-1.2-1.1-0.4
Total resting periods, locomotor time 10.91.02.0-1.4-1.3-1.1-1.11.1-0.3-0.5-1.1-0.9-0.3
Rest time, locomotor task time 10.60.71.8-1.0-1.4-1.10.4-0.40.7-0.4-1.1-0.7-0.5
Distance moved, locomotor task time 10.10.20.70.30.80.8-0.10.1-0.6-0.40.1-0.1-0.2
Vertical activity count, locomotor time 10.30.71.5-0.80.00.1-1.21.2-1.2-0.8-0.7-0.9-0.3
Time >=10cm from walls, locomotor time 20.71.01.9-0.7-0.9-0.8-1.31.3-1.4-0.90.20.61.2
Bouts of movement, locomotor time 21.62.64.9-2.0-1.5-1.5-2.22.2-1.8-1.7-0.9-0.70.3
Total resting periods, locomotor time 21.42.54.9-1.9-1.6-1.7-2.22.2-1.9-1.3-0.6-0.30.7
Rest time, locomotor task time 20.60.71.80.4-0.5-0.70.8-0.80.60.90.91.11.3
Distance moved, locomotor task time 21.41.63.7-1.00.40.7-0.90.9-0.5-1.8-1.7-1.9-1.7
Vertical activity count, locomotor time 21.82.55.5-2.0-0.6-0.2-1.41.4-1.1-1.7-2.2-2.3-1.5
Light reinforcement 10.71.83.71.91.71.71.0-1.01.01.41.51.30.4
Light reinforcement 20.30.51.41.00.60.80.6-0.60.31.20.80.60.3
Bone: marrow area0.71.53.0-1.7-0.9-1.0-1.01.0-0.8-1.5-1.7-1.6-0.6
Bone: maximum diameter1.63.04.9-2.1-2.2-2.2-2.12.1-2.2-1.1-0.7-0.30.9
Bone: maximum force1.73.15.6-2.4-2.2-2.2-1.91.9-1.8-1.6-1.3-0.80.7
Bone: maximum moment1.62.75.1-2.3-2.0-2.0-1.81.8-1.6-1.6-1.2-0.80.5
Mean time between licks in bursts0.41.12.31.41.51.51.1-1.11.00.60.60.3-0.4
Mean num. licks in bursts0.30.51.10.6-0.2-0.31.0-1.00.40.90.60.80.5
Cd content in liver1.82.05.60.21.11.41.4-1.41.5-0.4-1.3-1.6-2.4
Co content in liver1.41.64.30.60.70.82.1-2.11.71.2-0.4-0.6-1.0
Cu content in liver0.30.30.9-0.5-0.3-0.2-0.90.9-0.9-0.4-0.2-0.3-0.1
Fe content in liver5.46.611.6-2.2-2.8-3.0-3.43.4-3.4-1.50.20.72.8
K content in liver0.20.20.30.50.40.20.4-0.40.30.20.40.60.3
Mg content in liver0.50.51.20.60.50.41.1-1.10.81.10.20.1-0.4
Mn content in liver0.60.71.50.51.21.20.8-0.80.7-0.7-0.5-0.6-0.7
Na content in liver0.50.50.9-0.8-0.8-0.9-0.70.7-1.0-0.5-0.20.00.9
Rb content in liver1.82.14.52.11.31.10.8-0.80.81.62.11.90.8
Se content in liver2.63.07.5-0.5-1.8-2.1-1.31.3-2.10.51.62.02.7
Sr content in liver0.70.61.8-0.9-0.4-0.20.1-0.1-0.0-1.3-1.3-1.2-0.6
Zn content in liver2.02.25.0-2.2-1.8-1.7-1.11.1-1.5-1.2-1.6-1.4-0.6
Bone: minimum diameter0.00.10.30.10.60.4-0.30.3-0.0-0.10.0-0.1-0.4
Time in familiar zone, hab. session 10.20.20.5-0.00.10.0-0.70.7-0.5-0.60.30.30.6
Time in novel zone, hab. session 10.40.40.7-0.7-0.4-0.2-0.50.5-0.4-0.6-0.8-0.9-0.7
Total zone transitions, hab. session 11.52.13.40.91.61.81.8-1.81.6-1.4-1.1-0.9-1.1
Total locomotion distance, hab. session 10.40.61.21.10.80.90.7-0.70.8-0.10.60.90.7
Locomotion velocity, hab. session 11.52.14.02.01.61.61.5-1.51.60.91.21.30.4
Time in familiar zone, hab. session 20.50.51.4-0.10.0-0.2-1.21.2-1.10.00.70.50.6
Time in novel zone, hab. session 20.50.51.30.60.40.51.1-1.11.10.4-0.1-0.0-0.5
Total zone transitions, hab. session 21.72.24.0-0.10.91.21.4-1.41.5-1.4-1.9-1.8-2.0
Total locomotion distance, hab. session 21.01.32.61.01.31.51.6-1.61.60.2-0.2-0.2-0.8
Locomotion velocity, hab. session 21.11.53.01.01.41.61.6-1.61.70.2-0.3-0.3-1.0
Novel to familiar place preference ratio0.91.02.10.81.21.31.1-1.11.10.7-0.2-0.6-1.5
Novelty place preference1.01.12.31.01.41.50.8-0.81.10.6-0.0-0.5-1.5
Time in novel zone, NPP test0.60.71.90.71.11.20.6-0.60.70.4-0.1-0.5-1.4
Total zone transitions, NPP test0.60.92.4-0.50.30.60.2-0.20.7-1.6-1.4-1.2-1.4
Total locomotion distance, NPP test0.40.61.40.80.70.81.0-1.01.20.50.30.5-0.2
Locomotion velocity, NPP test0.60.82.20.70.91.01.3-1.31.50.4-0.10.1-0.5
Intraocular pressure0.60.82.5-1.0-1.5-1.6-0.50.5-0.90.70.00.10.7
Delta distance traveled before/after self-admin0.80.92.8-1.1-0.9-0.6-0.30.30.0-1.7-1.5-1.1-0.4
Delta ambulatory time before/after self-admin0.20.31.5-0.4-0.3-0.1-0.20.20.3-1.2-0.8-0.5-0.3
Parametrial fat weight0.71.63.5-0.7-1.2-1.2-1.51.5-1.8-0.80.40.71.9
Pavlov. Cond. lever latency1.92.45.3-2.0-1.0-1.1-2.32.3-1.9-1.2-1.1-1.10.3
Pavlov. Cond. magazine entry latency0.50.71.6-0.3-0.20.11.3-1.30.8-0.3-1.0-0.9-1.0
Pavlov. Cond. change in total contacts0.40.40.70.80.30.40.8-0.80.60.20.60.80.2
Pavlov. Cond. index score0.50.72.40.6-0.00.21.5-1.51.10.50.10.3-0.4
Pavlov. Cond. latency score0.81.03.30.90.20.41.8-1.81.40.50.10.3-0.6
Pavlov. Cond. lever contacts2.12.55.22.01.01.12.3-2.31.91.51.11.2-0.4
Pavlov. Cond. magazine entry number0.40.51.20.20.2-0.1-1.11.1-0.70.10.70.70.9
Pavlov. Cond. intertrial magazine entries0.10.10.20.20.50.3-0.20.20.0-0.40.20.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.60.72.40.70.00.21.6-1.61.00.60.30.4-0.3
Pavlov. Cond. response bias0.50.72.50.3-0.10.11.6-1.60.90.4-0.3-0.2-0.6
Pavlov. Cond. lever latency0.00.00.2-0.10.10.2-0.00.00.00.2-0.2-0.4-0.3
Pavlov. Cond. magazine entry latency0.91.13.11.61.81.50.7-0.70.90.50.90.6-0.3
Pavlov. Cond. change in total contacts0.10.21.1-0.20.20.1-0.20.2-0.3-1.1-0.6-0.4-0.5
Pavlov. Cond. index score0.20.20.50.70.70.60.4-0.40.5-0.20.30.3-0.1
Pavlov. Cond. latency score0.20.20.50.70.70.50.4-0.40.4-0.20.40.4-0.1
Pavlov. Cond. lever contacts0.10.10.50.40.1-0.1-0.00.00.10.20.50.70.5
Pavlov. Cond. magazine entry number0.70.92.8-1.4-1.7-1.4-0.60.6-0.8-0.5-0.7-0.40.5
Pavlov. Cond. intertrial magazine entries0.50.71.7-1.2-0.9-0.8-0.10.1-0.1-0.7-1.3-1.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.70.90.70.4-0.40.5-0.30.20.2-0.3
Pavlov. Cond. response bias0.30.40.80.90.60.40.3-0.30.40.60.90.90.3
Time in closed arm before self-admin1.82.35.4-1.6-0.6-0.1-0.50.5-0.5-2.0-2.3-2.3-2.2
Time in closed arm after self-admin3.53.79.1-2.1-0.40.0-0.90.9-1.1-2.7-2.9-3.0-2.0
Time in open arm before self-admin0.20.20.7-0.4-0.2-0.4-0.70.7-0.70.10.00.00.8
Time in open arm after self-admin2.12.34.12.01.10.81.3-1.31.72.01.81.80.8
Bone: periosteal estimation1.22.65.1-2.3-1.7-1.8-1.71.7-1.7-1.5-1.4-1.20.0
Bone: periosteal perimeter1.93.26.1-1.8-1.9-2.1-2.52.5-2.4-1.1-0.20.21.2
Bone: post-yield work1.01.53.5-0.9-1.5-1.7-1.21.2-1.3-0.20.51.01.9
Progressive ratio test 1 active lever presses0.40.51.3-0.7-0.4-0.30.7-0.70.1-0.2-1.1-1.2-0.9
Progressive ratio test 1 breakpoint0.40.51.3-0.6-0.4-0.30.7-0.70.2-0.1-1.1-1.1-0.9
Progressive ratio test 1 inactive lever presses0.30.41.1-0.10.40.20.7-0.70.71.0-0.3-0.6-1.1
Progressive ratio test 2 active lever presses0.80.92.3-0.6-0.10.11.1-1.10.7-0.0-1.4-1.5-1.4
Progressive ratio test 2 breakpoint0.80.92.0-0.50.00.21.1-1.10.70.1-1.3-1.4-1.4
Progressive ratio test 2 inactive lever presses0.60.92.5-1.2-0.7-0.50.5-0.50.2-0.1-1.5-1.6-1.2
Incentive Sensitization - Responses0.50.71.50.80.70.71.2-1.21.20.90.20.0-0.5
Incentive Sensitization - Breakpoint0.60.71.50.80.70.81.2-1.21.20.90.20.0-0.5
Sum of active levers in priming session hrs 5-61.31.22.3-0.7-1.3-1.4-1.11.1-1.1-1.00.20.71.5
Progressive ratio0.81.32.11.41.21.01.2-1.21.41.40.80.5-0.7
Food seeking constrained by brief footshock0.20.21.0-0.0-0.4-0.1-0.60.6-1.0-0.30.40.3-0.0
Seeking ratio, punishment vs. effort1.42.04.2-1.8-1.3-0.8-1.21.2-1.8-2.0-1.5-1.2-0.0
Retroperitoneal fat weight1.35.510.3-1.0-2.0-2.1-3.03.0-3.2-1.11.51.93.1
Reaction time number correct0.91.73.0-1.7-1.0-1.0-1.41.4-1.0-1.4-1.5-1.4-0.8
Reaction time mean minus median1.12.76.11.31.51.52.5-2.52.11.3-0.1-0.3-1.4
Reaction time mean minus median AUC1.43.55.71.82.22.02.3-2.32.41.90.4-0.1-1.5
Reaction time num false alarms0.30.41.00.40.50.61.0-1.00.90.3-0.2-0.3-0.7
Reaction time num false alarms AUC0.00.10.20.0-0.2-0.10.4-0.40.30.30.0-0.0-0.3
Reaction time trials correct on left0.91.73.0-1.7-1.0-1.0-1.41.4-1.0-1.4-1.5-1.4-0.8
Reaction time trials on left0.81.62.8-1.7-0.9-0.9-1.31.3-1.0-1.4-1.5-1.4-0.9
Reaction time mean4.77.513.03.43.63.33.0-3.02.82.71.91.2-0.9
Reaction time mean AUC4.57.112.03.43.53.23.0-3.02.62.71.91.2-0.7
Median of all reaction times5.27.314.03.63.73.42.6-2.62.52.72.31.6-0.5
Reaction time omissions1.01.53.01.51.71.61.4-1.41.21.00.70.4-0.5
Reaction time false alarm rate0.30.40.80.80.30.30.9-0.90.70.90.70.60.2
Reaction time premature initiation rate2.83.811.61.61.31.43.4-3.42.61.00.10.1-0.8
Reaction time premature initiations1.01.75.50.60.60.82.3-2.31.80.1-0.7-0.5-1.0
Std. dev. reaction times2.34.37.42.22.52.42.7-2.72.41.80.70.2-1.3
Reaction time trials completed0.81.62.8-1.7-0.9-0.9-1.31.3-1.0-1.4-1.5-1.4-0.9
Reaction time trials AUC0.81.52.6-1.6-0.9-0.9-1.31.3-1.1-1.4-1.4-1.3-0.8
Run reversals in cocaine runway, females1.21.22.31.51.20.90.8-0.81.21.31.31.20.2
Run reversals in cocaine runway, males1.01.02.5-0.9-0.8-0.5-1.61.6-1.2-0.9-0.5-0.50.3
Latency to leave start box in cocaine runway0.80.92.20.40.1-0.2-1.11.1-0.81.11.51.20.7
Latency to leave start box in cocaine runway, F1.01.12.2-0.1-0.4-0.5-1.51.5-1.40.81.31.01.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.10.0-0.1-0.30.30.1-0.5-0.2-0.2-0.2
Std. dev. time between licks in bursts0.00.10.2-0.10.20.20.1-0.1-0.00.3-0.3-0.4-0.2
Total sessions with >9 infusions0.50.61.00.90.50.30.7-0.70.10.81.01.00.8
Short access day 1 total inactive lever presses0.10.10.3-0.3-0.4-0.40.5-0.5-0.5-0.0-0.2-0.10.6
Short access day 10 total inactive lever presses0.10.30.9-0.4-0.7-0.90.1-0.1-0.00.90.30.40.6
Short access day 1 total infusions0.60.81.61.10.50.30.9-0.90.00.81.21.31.0
Short access day 10 total infusions0.91.11.91.10.40.21.4-1.40.51.01.11.41.2
Short access total infusions1.11.52.41.50.70.61.5-1.50.71.31.31.41.0
Short access day 1 locomotion1.01.32.61.21.61.41.4-1.41.10.70.3-0.0-0.8
Short access day 10 total locomotion0.00.10.30.20.50.4-0.00.0-0.2-0.00.20.2-0.1
Short access total locomotion0.80.91.71.31.31.21.2-1.20.70.70.60.5-0.2
One hour access (0.3 mA shock)2.02.34.90.21.01.31.9-1.91.80.7-1.4-1.7-2.2
Compulsive drug intake0.70.81.61.31.21.20.6-0.61.00.90.60.3-0.4
One hour access (shock baseline)0.50.81.7-0.6-0.10.21.1-1.10.5-0.0-1.3-1.3-1.3
Social response proportion1.61.85.8-1.6-0.6-0.4-0.30.30.0-1.0-2.3-2.4-1.7
Social responses0.60.72.1-0.9-0.5-0.40.4-0.40.7-0.1-1.5-1.4-1.1
Social time1.82.56.82.02.62.51.0-1.01.41.10.70.1-1.4
Soleus weight1.23.58.3-2.4-2.5-2.9-1.91.9-2.3-0.6-0.40.01.5
Bone: stiffness0.40.71.2-1.0-1.0-1.1-1.01.0-0.9-0.7-0.3-0.10.8
Tibialis anterior weight3.110.522.4-4.7-4.3-4.4-2.72.7-3.3-2.7-2.7-1.91.1
Time to tail flick, vehicle, before self-admin0.10.10.30.50.20.40.3-0.30.10.10.50.50.4
Time to tail flick, vehicle, after self-admin0.60.81.4-0.7-0.6-0.7-1.21.2-1.2-1.1-0.20.10.9
Time to tail flick, test, before self-admin1.81.83.5-1.8-1.4-1.1-1.31.3-1.4-1.9-1.4-1.10.4
Time to tail flick, test, after self-admin0.40.41.00.50.2-0.2-0.10.1-0.60.41.01.00.9
Delta time to tail flick, vehicle, before/after SA0.80.82.4-0.5-0.2-0.5-1.61.6-1.2-0.30.40.50.8
Delta time to tail flick, test, before/after SA1.11.22.41.61.10.80.9-0.91.01.31.31.20.2
Tibia length3.08.216.1-4.0-2.7-2.6-3.43.4-2.9-2.6-2.8-2.6-0.6
Ambulatory time before self-admin0.30.40.90.70.50.40.2-0.20.11.00.90.90.6
Ambulatory time after self-admin0.10.10.2-0.0-0.3-0.1-0.30.30.0-0.20.10.30.4
Bone: tissue strength0.80.81.8-1.0-0.8-0.9-1.11.1-1.0-1.4-0.4-0.00.5
Total heroin consumption2.12.54.32.11.61.31.7-1.71.81.81.51.3-0.3
Bone: trabecular number6.210.215.3-3.7-3.9-3.6-3.83.8-3.9-3.0-1.4-0.62.0
Bone: trabecular spacing1.72.25.22.22.31.90.9-0.91.21.21.61.2-0.3
Bone: trabecular thickness5.16.411.9-2.8-3.4-3.3-2.82.8-3.3-1.2-0.50.12.1
Bone: trabecular tissue density0.40.62.00.90.90.7-0.10.10.11.41.20.70.1
Water consumed over 24 hours1.21.75.4-1.7-0.5-0.3-0.10.1-0.2-1.3-2.3-2.3-1.0
Number of responses in last shaping day0.10.10.10.30.1-0.0-0.10.1-0.20.20.40.40.3