Hub : Genes

Rxfp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Rxfp2 0.07 0.04 7.6e-08 0.04 0.06 0.06 0.05 5.0e-05 5.6e-08 5.6e-07 1.6e-06
2 Brain gene expression Rxfp2 0.16 0.07 1.1e-15 0.06 0.17 0.17 0.16 1.5e-06 3.1e-15 2.4e-15 7.5e-15
3 LHb gene expression Rxfp2 0.26 0.12 6.6e-05 0.2 0.18 0.2 0.21 1.7e-05 4.1e-05 1.4e-05 9.3e-06
4 Brain intron excision ratio chr12_4945988_4950591 0.1 0.07 1.8e-03 0.04 0.03 0.03 0.03 8.3e-05 5.6e-04 4.3e-04 4.3e-04
5 Brain intron excision ratio chr12_4945988_4950702 0.11 0.07 8.4e-04 0.04 0.03 0.04 0.03 7.4e-05 3.8e-04 2.6e-04 5.2e-04
6 OFC gene expression Rxfp2 0.71 0.1 7.6e-08 0.24 0.28 0.26 0.26 1.9e-06 1.9e-07 7.4e-07 5.6e-07
7 PL mRNA stability Rxfp2 0.09 0.05 1.8e-05 0.06 0.04 0.04 0.05 3.5e-07 3.1e-05 2.1e-05 2.6e-06
8 Brain mRNA stability Rxfp2 0.09 0.04 1.8e-06 0.04 0.06 0.06 0.07 6.5e-05 2.2e-06 3.4e-06 8.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density8.914.924.5-4.44.1-4.94.6-4.6-2.5-2.91.4
Area under the delay curve0.70.72.11.5-1.00.7-0.90.90.50.5-0.0
BMI with tail2.47.913.2-3.13.0-3.63.3-3.3-1.9-2.11.0
BMI without tail0.71.44.8-1.92.2-0.30.2-0.2-1.20.7-0.9
Body weight10.945.883.8-9.28.5-7.67.2-7.2-6.0-3.3-0.4
Weight adjusted by age1.82.06.7-1.31.6-1.01.2-1.2-2.60.0-1.0
Bone surface8.314.723.2-4.54.3-4.84.5-4.5-2.9-2.40.9
Bone volume8.213.923.9-3.93.5-4.94.6-4.6-2.0-3.02.0
Breakpoint value in progressive ratio session0.60.71.7-0.1-0.61.3-1.21.20.4-0.20.4
Number of licking bursts2.32.66.6-0.81.8-0.71.2-1.2-2.01.9-2.6
Context. condit. distance diff. score2.12.56.8-2.61.6-1.31.5-1.5-0.0-1.81.2
Locomotion velocity, session 11.31.43.00.8-0.81.4-1.71.7-0.71.0-0.8
Locomotion distance, session 10.60.81.81.3-0.70.7-0.90.9-0.90.8-0.5
Locomotion velocity, session 21.82.15.20.8-0.21.0-1.21.2-1.62.3-2.2
Locomotion distance, session 21.62.25.01.30.10.5-0.90.9-2.22.1-2.2
Locomotion velocity, session 30.40.40.9-0.60.4-0.80.9-0.90.1-0.60.5
Locomotion distance, session 30.00.00.1-0.10.1-0.20.4-0.40.0-0.00.1
Stereotopy head waving bouts, day 30.70.82.2-1.41.5-0.50.4-0.4-1.30.0-0.5
Stereotopy head waving duration, day 30.00.00.10.1-0.10.0-0.10.1-0.2-0.30.4
Locomotion velocity, session 70.30.41.00.9-1.00.0-0.20.20.6-0.70.6
Locomotion distance, session 70.20.20.50.4-0.70.1-0.30.30.6-0.70.5
Stereotopy head waving bouts, day 72.32.65.21.7-1.82.3-1.91.91.11.1-0.4
Stereotopy head waving duration, day 71.61.93.81.6-1.52.0-1.41.40.61.4-0.9
Locomotion velocity, session 80.60.81.60.1-0.41.1-1.31.3-0.40.9-0.8
Locomotion distance, session 80.91.32.9-1.51.6-1.00.9-0.9-1.7-0.4-0.4
Degree of sensitization distance0.80.81.61.2-1.10.9-1.31.30.20.3-0.3
Degree of sensitization stereotypy2.02.24.81.5-1.72.2-1.51.51.41.1-0.5
Conditioned locomotion0.81.02.0-0.71.0-1.00.5-0.5-1.2-1.41.2
Cocaine response after cond. corrected0.80.92.90.4-0.80.6-0.40.41.7-0.81.4
Cocaine response after cond. not corrected1.21.43.70.4-1.10.6-0.60.61.8-1.21.9
Cocaine response before conditioning0.20.31.0-0.4-0.2-0.3-0.20.2-0.1-1.00.8
Saline control response1.52.04.5-1.61.60.10.0-0.0-2.11.4-2.1
Bone: connectivity density9.314.722.6-4.84.4-4.74.3-4.3-3.4-2.10.2
Bone: cortical apparent density0.10.10.20.4-0.3-0.20.1-0.10.2-0.40.4
Bone: cortical area3.65.48.7-2.42.5-3.02.9-2.9-1.4-1.60.9
Bone: cortical porosity0.91.01.60.9-0.91.2-1.11.10.71.1-0.6
Bone: cortical porosity1.11.21.91.2-1.21.4-1.21.20.61.2-0.6
Bone: cortical thickness2.84.67.4-2.32.4-2.72.6-2.6-1.2-1.51.0
Bone: cortical thickness0.30.31.2-0.91.1-0.50.4-0.4-0.3-0.00.2
Bone: cortical tissue density0.10.10.30.5-0.4-0.1-0.10.10.3-0.40.4
Condit. Reinf. active minus inactive responses1.11.22.4-0.20.7-1.31.5-1.5-1.5-0.60.4
Condit. Reinf. active-inactive response ratio0.91.02.4-0.20.4-1.21.5-1.5-0.6-0.70.8
Condit. Reinf. active responses0.20.21.1-0.00.3-0.30.5-0.5-1.00.1-0.0
Condit. Reinf. inactive responses1.01.22.30.8-0.81.4-1.51.50.31.0-0.6
Incentive salience index mean0.50.61.0-0.10.5-1.01.0-1.0-0.9-0.80.8
Condit. Reinf. lever presses0.20.31.30.2-0.1-0.1-0.20.20.4-1.01.1
Condit. Reinf. active minus inactive responses0.40.51.5-0.40.60.1-0.20.2-0.61.1-1.2
Condit. Reinf. active-inactive response ratio0.70.71.70.3-0.00.5-0.90.9-0.71.3-1.3
Condit. Reinf. active responses0.40.50.9-0.90.9-0.30.4-0.4-0.90.5-1.0
Condit. Reinf. inactive responses0.40.61.1-1.10.8-0.70.9-0.9-0.4-0.60.2
Condit. Reinf. lever presses1.31.82.7-1.21.0-1.61.6-1.6-0.8-1.61.0
Condit. Reinf. lever reinforcers received0.40.51.2-0.70.8-0.40.5-0.5-1.10.5-1.0
Conditioned reinforcement - actives1.01.03.9-2.01.60.40.1-0.1-0.40.6-1.1
Conditioned reinforcement - inactives0.40.42.3-0.30.20.6-0.20.21.50.50.1
Conditioned locomotion0.70.82.0-1.41.01.1-0.40.4-0.40.9-1.1
Patch foraging indifference point 0 sec2.64.27.1-1.51.5-2.52.7-2.7-1.2-2.31.3
Patch foraging indifference point AUC0.91.02.1-1.31.5-1.11.0-1.0-1.1-0.2-0.2
Delay disc. indifference point, 0s delay0.10.10.20.4-0.1-0.40.4-0.4-0.2-0.20.1
Delay disc. indifference point, 16s delay0.60.72.11.1-1.00.6-0.50.51.40.40.3
Delay disc. indifference point, 2s delay1.41.53.71.9-1.91.1-1.11.10.7-0.40.8
Delay disc. indifference point, 24s delay1.01.02.11.4-1.11.0-0.80.80.90.9-0.6
Delay disc. indifference point, 4s delay0.70.72.01.4-1.00.3-0.80.80.7-0.40.8
Delay disc. indifference point, 8s delay0.20.20.60.8-0.40.1-0.40.4-0.20.4-0.0
Indifference point function ln k0.10.20.7-0.30.20.20.2-0.2-0.30.6-0.8
Indifference point function log k0.10.20.7-0.30.20.20.2-0.2-0.30.6-0.8
Patch foraging total patch changes 0 sec2.64.26.8-1.61.5-2.42.6-2.6-1.1-2.41.4
Patch foraging total patch changes 12 sec3.95.19.7-1.71.9-3.12.7-2.7-0.9-2.61.6
Patch foraging total patch changes 18 sec1.21.52.6-1.00.9-1.41.6-1.6-0.0-1.51.1
Patch foraging total patch changes 24 sec1.61.93.1-1.01.1-1.61.7-1.7-0.7-1.81.1
Patch foraging total patch changes 6 sec1.52.23.3-1.41.4-1.61.7-1.7-0.7-1.81.1
Patch foraging time to switch 0 sec1.93.05.92.2-2.41.4-1.61.62.1-0.61.3
Patch foraging water rate 0 sec3.04.810.0-3.13.2-2.42.0-2.0-2.1-0.4-0.7
Patch foraging water rate 12 sec1.01.53.2-0.91.4-0.80.8-0.8-1.81.0-1.7
Patch foraging water rate 18 sec0.50.71.40.4-0.20.8-0.90.9-0.61.2-1.0
Patch foraging water rate 24 sec1.82.56.4-1.72.2-0.90.9-0.9-2.50.8-1.7
Patch foraging water rate 6 sec1.01.52.5-1.31.4-1.61.4-1.4-1.2-0.0-0.6
Seeking ratio, delayed vs. immediate footshock1.82.13.21.5-1.81.5-1.81.81.3-0.11.0
Distance traveled before self-admin0.70.72.00.9-1.30.20.0-0.01.4-0.31.0
Distance traveled after self-admin0.10.10.3-0.30.0-0.30.5-0.5-0.4-0.00.1
Extensor digitorum longus weight2.28.522.6-4.83.9-3.03.0-3.0-1.2-1.3-0.1
Bone: elastic displacement0.80.91.70.2-0.11.0-1.31.30.11.3-1.1
Bone: elastic work2.43.17.7-2.42.8-1.91.4-1.4-1.8-0.0-0.9
Bone: endosteal estimation0.91.93.1-1.51.8-1.01.2-1.2-1.60.7-1.6
Bone: endosteal perimeter1.42.94.4-2.12.1-1.92.0-2.0-1.4-0.6-0.2
Epididymis fat weight1.43.26.2-1.51.2-2.42.5-2.5-0.3-1.61.2
Delta time in closed arm before/after self-admin0.20.20.6-0.30.2-0.30.4-0.4-0.00.7-0.8
Delta time in open arm before/after self-admin3.63.55.92.3-2.42.0-1.81.82.2-0.21.2
Diff in mean of infusions in LGA sessions0.40.51.50.1-0.40.6-0.80.81.20.00.6
Delay discount exponential model param0.91.02.5-1.61.2-0.91.0-1.0-0.8-0.60.0
Extinction: sum of active levers before priming0.60.61.9-0.0-0.5-0.10.6-0.6-0.1-1.31.4
Active lever presses in extinction session 61.41.32.5-1.30.8-1.31.6-1.6-0.2-1.00.7
Bone: final force1.93.06.0-2.22.5-2.11.6-1.6-1.8-0.3-0.5
Bone: final moment1.62.75.4-2.12.3-1.91.5-1.5-1.8-0.1-0.6
Food consumed during 24 hour testing period0.70.81.80.3-0.31.3-1.21.20.70.9-0.4
Glucose0.10.20.40.6-0.50.1-0.10.10.30.60.0
Heart weight0.71.03.1-0.30.80.00.1-0.1-1.21.6-1.8
Delay discount hyperbolic model param1.01.02.8-1.71.3-0.91.1-1.1-0.7-0.5-0.1
Intermittent access intake day 1-15 change0.30.30.8-0.80.90.1-0.00.0-0.60.5-0.6
Intermittent access intake escalation0.40.41.2-0.91.1-0.0-0.00.0-0.80.5-0.8
Intermittent access intake escalation 20.10.10.6-0.10.50.1-0.10.1-0.80.1-0.4
Intermitt. access day 1 inactive lever presses0.60.72.4-0.30.70.1-0.00.00.41.6-1.5
Intermitt. access day 15 inactive lever presses1.31.55.50.8-1.20.8-0.50.52.4-0.61.6
Intermitt. access escalation Index0.20.20.50.00.3-0.70.0-0.0-0.30.6-0.7
Intermittent access day 1 total infusions2.32.74.91.5-1.72.2-2.02.01.70.20.6
Intermittent access day 15 total infusions1.11.33.20.4-0.51.8-1.71.70.50.6-0.3
Intermittent access terminal intake (last 3 days)1.51.64.01.0-1.12.0-1.71.71.10.10.5
Intermittent access total infusions3.03.37.11.5-1.62.7-2.42.41.60.30.5
Intermittent access day 1 locomotion2.83.05.21.9-2.02.3-2.12.11.40.50.3
Intermittent access day 15 total locomotion1.81.95.50.7-0.72.3-1.81.80.41.2-0.9
Intermittent access total locomotion3.23.68.71.7-1.73.0-2.42.41.21.1-0.4
Intermittent access standard deviation0.10.10.2-0.40.40.3-0.00.0-0.5-0.30.1
Left kidney weight6.919.337.8-6.15.9-4.64.8-4.8-3.3-0.3-1.7
Right kidney weight7.420.936.2-6.05.8-5.15.1-5.1-4.0-0.8-1.7
Cocaine induced anxiety0.30.41.10.1-0.50.2-0.50.50.4-1.01.0
Post-drug Anxiety4.75.28.62.6-2.92.5-2.92.91.5-0.00.7
Baseline Anxiety3.13.37.02.6-2.61.8-1.71.71.70.60.3
Tail length1.85.415.2-3.93.9-0.80.6-0.6-2.61.0-2.1
Length with tail8.029.469.0-8.37.6-5.45.0-5.0-5.1-1.6-1.5
Length without tail13.028.443.8-6.65.6-6.66.3-6.3-3.9-3.80.6
Times rat made contact with spout1.31.55.2-0.71.00.8-0.40.4-1.41.6-2.3
Lifetime Intake2.83.16.31.4-1.82.5-2.22.21.8-0.21.0
Liver weight, left4.87.612.2-2.92.8-3.43.5-3.5-2.1-1.90.8
Liver weight, right6.310.518.2-4.14.3-3.53.1-3.1-3.9-0.5-1.5
Locomotor activity1.11.73.6-1.51.7-0.50.8-0.8-0.91.6-1.9
Locomotor testing distance0.50.91.8-1.21.2-0.40.7-0.7-0.41.0-1.3
Locomotor testing rearing0.00.10.40.1-0.0-0.10.3-0.30.00.2-0.6
Locomotion in novel chamber2.02.56.20.10.41.5-1.51.5-0.82.5-2.5
Locomotion in novel chamber post-restriction1.92.35.1-1.21.60.6-1.01.0-1.81.9-2.2
Fecal boli incidents, locomotor time 10.60.71.7-1.31.1-0.40.6-0.6-1.00.1-0.9
Change in fecal boli incidents, locomotor task0.60.61.50.9-0.80.5-0.70.71.20.30.5
Time >=10cm from walls, locomotor time 11.01.02.80.8-1.1-0.40.2-0.20.7-1.61.7
Bouts of movement, locomotor time 10.60.71.9-1.21.4-0.40.8-0.8-0.50.4-0.2
Total resting periods, locomotor time 10.60.61.4-1.11.2-0.41.0-1.0-0.30.30.1
Rest time, locomotor task time 10.20.20.3-0.50.40.5-0.50.5-0.30.4-0.5
Distance moved, locomotor task time 10.10.10.40.3-0.1-0.50.4-0.4-0.60.2-0.2
Vertical activity count, locomotor time 10.80.81.9-0.71.1-1.41.0-1.0-0.90.4-0.3
Time >=10cm from walls, locomotor time 21.41.52.8-0.90.7-1.61.7-1.7-0.9-1.20.4
Bouts of movement, locomotor time 23.63.96.7-1.92.4-2.62.4-2.4-1.9-0.2-0.2
Total resting periods, locomotor time 23.33.56.3-1.92.2-2.52.3-2.3-1.5-0.60.1
Rest time, locomotor task time 20.80.91.70.2-0.80.9-1.01.00.8-1.21.3
Distance moved, locomotor task time 21.51.73.5-0.31.1-0.91.2-1.2-1.71.5-1.9
Vertical activity count, locomotor time 22.62.85.1-1.82.3-1.61.5-1.5-1.71.3-1.6
Light reinforcement 11.01.94.81.6-2.21.7-1.01.01.5-0.00.7
Light reinforcement 20.40.51.30.7-0.80.8-0.50.51.2-0.00.5
Bone: marrow area0.81.83.1-1.51.8-1.01.1-1.1-1.60.7-1.6
Bone: maximum diameter2.34.26.4-2.32.4-2.52.5-2.5-1.5-1.00.2
Bone: maximum force2.95.18.1-2.62.7-2.92.6-2.6-1.9-1.10.2
Bone: maximum moment2.64.57.2-2.52.6-2.72.4-2.4-1.8-0.90.1
Mean time between licks in bursts0.60.82.81.7-1.00.7-0.90.90.40.4-0.2
Mean num. licks in bursts0.81.02.00.3-0.91.0-1.41.40.8-0.80.8
Cd content in liver1.51.72.51.4-1.01.4-1.51.50.41.6-1.3
Co content in liver1.41.63.50.5-0.51.9-1.71.71.01.3-0.5
Cu content in liver1.11.42.5-1.11.3-1.41.6-1.6-1.1-0.3-0.1
Fe content in liver8.29.915.2-3.53.1-3.93.9-3.9-1.7-2.71.3
K content in liver0.20.20.30.4-0.50.5-0.60.60.30.30.2
Mg content in liver0.50.51.00.3-0.50.9-1.01.00.70.8-0.3
Mn content in liver0.30.30.80.7-0.90.6-0.30.3-0.60.1-0.6
Na content in liver0.30.30.9-0.50.2-0.70.3-0.3-0.5-0.90.4
Rb content in liver1.21.43.01.4-1.70.4-0.30.31.6-0.81.7
Se content in liver2.12.56.2-1.30.6-1.61.5-1.50.5-2.52.2
Sr content in liver0.50.52.1-0.60.60.10.1-0.1-1.50.6-0.8
Zn content in liver2.83.05.7-2.32.4-1.71.6-1.6-1.90.6-1.1
Bone: minimum diameter0.10.20.40.10.0-0.50.7-0.7-0.10.4-0.2
Time in familiar zone, hab. session 10.40.41.10.20.0-0.71.1-1.1-0.5-0.20.1
Time in novel zone, hab. session 10.30.30.6-0.60.50.00.0-0.0-0.70.5-0.8
Total zone transitions, hab. session 11.52.02.81.7-1.01.4-1.61.6-1.31.4-1.4
Total locomotion distance, hab. session 10.30.51.71.3-1.10.2-0.50.5-0.0-0.40.6
Locomotion velocity, hab. session 11.31.84.42.1-1.90.9-1.31.31.0-0.30.8
Time in familiar zone, hab. session 20.90.92.7-0.20.1-1.01.6-1.60.1-0.60.5
Time in novel zone, hab. session 20.80.82.30.7-0.50.9-1.51.50.30.5-0.2
Total zone transitions, hab. session 21.41.84.40.50.21.2-1.31.3-1.41.8-2.1
Total locomotion distance, hab. session 20.81.12.11.3-0.91.1-1.41.40.30.7-0.6
Locomotion velocity, hab. session 20.91.22.31.3-0.91.1-1.51.50.30.8-0.7
Novel to familiar place preference ratio1.51.63.10.9-0.71.4-1.51.50.71.8-1.2
Novelty place preference1.41.53.31.1-0.91.3-1.21.20.61.8-1.2
Time in novel zone, NPP test1.01.02.80.8-0.61.0-1.01.00.41.7-1.2
Total zone transitions, NPP test0.50.72.20.10.50.4-0.20.2-1.51.2-1.4
Total locomotion distance, NPP test0.40.50.90.9-0.80.7-1.01.00.60.10.3
Locomotion velocity, NPP test0.50.81.60.9-0.71.0-1.31.30.60.5-0.1
Intraocular pressure0.50.72.5-1.61.1-0.40.5-0.50.6-0.80.4
Delta distance traveled before/after self-admin0.80.93.4-0.71.2-0.40.3-0.3-1.90.4-0.9
Delta ambulatory time before/after self-admin0.50.52.7-0.40.8-0.50.3-0.3-1.70.2-0.6
Parametrial fat weight0.10.20.7-0.20.4-0.70.1-0.1-0.80.1-0.2
Pavlov. Cond. lever latency2.43.15.5-2.21.8-2.02.3-2.3-1.1-0.1-0.6
Pavlov. Cond. magazine entry latency0.50.71.30.10.31.0-1.21.2-0.60.8-0.8
Pavlov. Cond. change in total contacts0.40.40.70.8-0.60.7-0.80.80.1-0.60.6
Pavlov. Cond. index score0.60.81.90.7-0.51.2-1.41.40.3-0.10.3
Pavlov. Cond. latency score0.91.12.71.0-0.71.4-1.61.60.30.10.2
Pavlov. Cond. lever contacts2.42.95.01.9-1.71.9-2.22.21.4-0.10.9
Pavlov. Cond. magazine entry number0.30.40.80.2-0.4-0.80.9-0.90.3-0.50.7
Pavlov. Cond. intertrial magazine entries0.10.10.20.3-0.40.00.4-0.4-0.4-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.60.71.80.7-0.51.1-1.31.30.4-0.30.4
Pavlov. Cond. response bias0.60.72.00.3-0.21.3-1.41.40.30.00.1
Pavlov. Cond. lever latency0.10.10.2-0.10.10.2-0.40.40.40.4-0.4
Pavlov. Cond. magazine entry latency0.60.72.81.7-1.30.6-0.40.40.50.00.1
Pavlov. Cond. change in total contacts0.20.20.9-0.10.2-0.40.5-0.5-1.00.2-0.4
Pavlov. Cond. index score0.10.10.50.7-0.60.20.0-0.0-0.3-0.20.3
Pavlov. Cond. latency score0.10.20.60.8-0.70.10.1-0.1-0.2-0.30.3
Pavlov. Cond. lever contacts0.40.51.80.2-0.4-0.30.4-0.40.4-1.11.3
Pavlov. Cond. magazine entry number0.50.62.3-1.51.2-0.50.2-0.2-0.5-0.3-0.0
Pavlov. Cond. intertrial magazine entries0.30.40.9-1.00.9-0.1-0.20.2-0.80.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.8-0.60.20.0-0.0-0.30.00.0
Pavlov. Cond. response bias0.40.51.60.7-0.80.00.1-0.10.7-0.81.3
Time in closed arm before self-admin1.51.73.8-1.21.6-0.70.8-0.8-1.61.2-2.0
Time in closed arm after self-admin3.23.27.0-1.42.0-1.31.3-1.3-2.31.6-2.6
Time in open arm before self-admin0.40.40.7-0.70.6-0.90.7-0.7-0.6-0.40.2
Time in open arm after self-admin1.31.42.71.0-1.31.3-1.11.11.6-0.51.3
Bone: periosteal estimation1.94.06.7-2.42.6-2.22.3-2.3-1.9-0.2-0.7
Bone: periosteal perimeter2.64.47.7-2.12.1-2.82.7-2.7-1.3-1.20.5
Bone: post-yield work0.91.31.9-1.10.7-1.21.4-1.4-0.2-1.41.2
Progressive ratio test 1 active lever presses0.20.20.7-0.30.30.8-0.40.40.00.5-0.2
Progressive ratio test 1 breakpoint0.30.31.0-0.10.21.0-0.60.6-0.10.7-0.4
Progressive ratio test 1 inactive lever presses0.50.51.6-0.50.90.2-0.20.20.51.3-1.1
Progressive ratio test 2 active lever presses1.01.12.1-0.50.61.5-1.31.3-0.01.2-1.2
Progressive ratio test 2 breakpoint1.51.73.90.00.12.0-1.61.60.21.6-1.3
Progressive ratio test 2 inactive lever presses1.01.12.1-1.31.50.7-0.70.70.11.4-1.4
Incentive Sensitization - Responses1.11.12.60.6-0.51.6-1.51.50.70.9-0.5
Incentive Sensitization - Breakpoint1.01.12.40.5-0.41.6-1.41.40.70.9-0.5
Sum of active levers in priming session hrs 5-60.90.83.30.2-0.3-0.50.2-0.2-0.5-1.81.6
Progressive ratio1.21.43.50.9-1.51.9-1.41.41.00.30.1
Food seeking constrained by brief footshock0.20.20.5-0.00.3-0.60.5-0.5-0.70.0-0.1
Seeking ratio, punishment vs. effort1.82.14.0-1.21.9-2.01.5-1.5-1.8-0.0-0.6
Retroperitoneal fat weight1.34.38.3-0.0-0.6-2.32.5-2.5-0.1-2.92.9
Reaction time number correct1.11.62.7-1.41.6-1.21.4-1.4-1.40.5-0.9
Reaction time mean minus median2.53.36.81.1-1.32.4-2.62.61.41.3-0.6
Reaction time mean minus median AUC2.83.76.21.5-1.62.5-2.52.52.11.2-0.4
Reaction time num false alarms0.30.51.20.4-0.51.1-0.80.80.10.6-0.8
Reaction time num false alarms AUC0.10.10.3-0.1-0.20.6-0.20.20.20.0-0.3
Reaction time trials correct on left1.11.62.7-1.41.6-1.21.4-1.4-1.40.5-0.9
Reaction time trials on left1.11.52.5-1.31.6-1.11.3-1.3-1.30.6-1.0
Reaction time mean4.96.810.93.3-3.22.7-2.72.73.11.20.6
Reaction time mean AUC4.86.510.13.2-3.12.6-2.72.73.11.00.7
Median of all reaction times4.76.512.83.6-3.42.3-2.22.23.20.81.1
Reaction time omissions1.62.23.31.8-1.71.7-1.71.71.60.50.3
Reaction time false alarm rate0.30.51.00.5-0.81.0-0.80.80.8-0.30.2
Reaction time premature initiation rate3.14.19.21.4-1.93.0-2.82.81.10.8-0.2
Reaction time premature initiations1.11.64.20.7-0.92.0-1.81.80.10.9-0.6
Std. dev. reaction times3.34.67.62.0-2.02.6-2.82.82.11.4-0.3
Reaction time trials completed1.11.52.5-1.31.6-1.11.3-1.3-1.30.6-1.0
Reaction time trials AUC1.01.52.2-1.31.5-1.21.4-1.4-1.30.5-0.9
Run reversals in cocaine runway, females0.90.81.51.2-1.01.0-1.01.01.10.30.3
Run reversals in cocaine runway, males0.80.81.8-0.80.7-1.01.3-1.3-0.8-0.3-0.1
Latency to leave start box in cocaine runway0.40.41.00.1-0.9-0.20.4-0.41.0-0.51.0
Latency to leave start box in cocaine runway, F0.60.61.3-0.3-0.3-0.80.8-0.81.2-0.71.1
Latency to leave start box in cocaine runway, M0.20.20.60.3-0.70.8-0.40.4-0.60.2-0.2
Std. dev. time between licks in bursts0.00.00.2-0.20.10.20.1-0.10.40.1-0.2
Total sessions with >9 infusions0.40.41.5-0.1-0.30.5-0.60.60.3-1.21.0
Short access day 1 total inactive lever presses0.40.51.5-0.0-0.11.2-0.90.90.40.5-0.5
Short access day 10 total inactive lever presses0.60.61.4-1.01.20.4-0.70.70.00.8-0.9
Short access day 1 total infusions1.71.84.11.0-1.61.0-0.70.71.3-1.72.0
Short access day 10 total infusions2.12.44.61.2-1.82.1-1.61.61.3-1.11.4
Short access total infusions2.02.33.31.2-1.81.8-1.31.31.5-1.21.7
Short access day 1 locomotion2.22.44.51.8-2.02.1-1.71.71.20.6-0.0
Short access day 10 total locomotion0.20.30.80.7-0.90.7-0.20.20.4-0.20.4
Short access total locomotion1.71.83.51.6-1.81.9-1.41.40.9-0.00.6
One hour access (0.3 mA shock)3.13.67.81.0-0.92.8-2.42.41.72.0-1.2
Compulsive drug intake1.81.83.41.9-1.61.2-1.61.61.00.9-0.5
One hour access (shock baseline)0.50.61.7-0.50.41.3-0.70.70.31.1-0.8
Social response proportion1.31.43.5-1.31.60.10.1-0.1-0.91.6-1.9
Social responses0.60.71.5-1.00.70.9-0.70.7-0.01.0-1.2
Social time1.31.74.82.2-1.71.0-0.80.81.11.3-0.3
Soleus weight1.23.58.4-2.92.2-2.02.1-2.1-0.6-1.20.2
Bone: stiffness1.21.93.1-1.41.5-1.81.7-1.7-1.0-1.00.4
Tibialis anterior weight3.110.724.1-4.94.5-3.43.2-3.2-2.7-1.1-0.8
Time to tail flick, vehicle, before self-admin0.40.40.80.8-0.90.5-0.80.8-0.00.4-0.2
Time to tail flick, vehicle, after self-admin0.10.10.5-0.1-0.1-0.30.2-0.2-0.7-0.70.2
Time to tail flick, test, before self-admin2.32.33.2-1.61.4-1.51.8-1.8-1.5-1.50.7
Time to tail flick, test, after self-admin0.80.82.9-0.40.1-0.70.5-0.5-0.4-1.71.6
Delta time to tail flick, vehicle, before/after SA0.70.71.9-0.30.1-0.80.9-0.90.3-1.41.2
Delta time to tail flick, test, before/after SA0.60.50.90.8-0.80.6-1.01.00.5-0.00.4
Tibia length3.18.918.5-3.84.3-3.33.0-3.0-2.50.2-1.6
Ambulatory time before self-admin0.40.41.10.5-1.00.5-0.00.01.0-0.50.8
Ambulatory time after self-admin0.10.10.2-0.3-0.20.10.4-0.4-0.5-0.50.4
Bone: tissue strength0.70.71.2-0.70.8-1.11.0-1.0-1.1-0.4-0.2
Total heroin consumption3.44.07.62.2-2.72.3-2.02.02.30.30.8
Bone: trabecular number8.112.620.7-4.04.0-4.54.1-4.1-2.9-2.20.7
Bone: trabecular spacing1.82.45.62.4-2.41.6-1.31.31.40.30.3
Bone: trabecular thickness6.17.311.5-3.43.0-3.33.1-3.1-1.4-2.01.3
Bone: trabecular tissue density0.30.41.60.4-0.6-0.20.4-0.41.3-0.20.6
Water consumed over 24 hours1.31.63.4-1.51.9-0.70.9-0.9-1.30.7-1.6
Number of responses in last shaping day0.10.10.2-0.30.2-0.10.4-0.40.20.2-0.1