Runx1t1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_008763550.4	0.03	0.03	3.1e-03	0.02	0.01	0.01	0.01	4.6e-03	4.0e-02	6.9e-02	1.6e-02
2	Adipose	alternative TSS	XM_008763550.4	0.04	0.03	1.7e-03	0.02	0.01	0.01	0.01	2.6e-03	2.3e-02	2.3e-02	7.5e-03
3	NAcc	alternative polyA	XM_006237901.5	0.01	0.01	5.9e-03	0.01	0.01	0.01	0.01	4.3e-03	1.2e-02	9.5e-03	8.2e-03
4	PL	mRNA stability	Runx1t1	0.06	0.05	7.4e-04	0.03	0.02	0.03	0.03	1.1e-04	3.3e-03	3.3e-04	2.0e-04
5	NAcc	mRNA stability	Runx1t1	0.05	0.03	7.7e-07	0.04	0.04	0.04	0.04	1.7e-06	8.4e-07	2.3e-07	4.5e-06
6	Adipose	isoform ratio	XM_006237901.5	0.02	0.01	6.1e-03	0.01	0	0.01	0.01	9.7e-03	9.3e-02	2.1e-02	2.8e-02
7	NAcc	gene expression	Runx1t1	0.04	0.03	3.1e-03	0.02	0.01	0.01	0.02	2.4e-04	2.6e-03	7.0e-03	1.5e-03
8	IC	isoform ratio	NM_001108657.1	0.15	0.1	2.7e-03	0.01	0.06	0.03	0.04	7.4e-02	1.8e-03	2.3e-02	1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.2	2.2	3.4	1.8	1.8	1.8	1.7	0.4	-1.5	-0.3	-1.4
Area under the delay curve	0.7	1.1	3.3	-0.9	-0.9	-1.1	-1.2	-1.8	0.5	-0.1	0.9
BMI with tail	2.1	7.2	12.1	3.5	3.5	2.9	2.9	2.9	-2.7	-0.8	-0.6
BMI without tail	0.8	4.3	8.4	2.9	2.9	2.1	2.1	1.6	-2.0	0.0	-1.4
Body weight	2.2	9.8	16.5	3.4	3.4	4.1	3.9	3.2	-2.9	-2.3	-0.0
Weight adjusted by age	0.3	0.7	1.3	0.8	0.8	1.1	1.1	0.4	-1.1	-0.6	0.4
Bone surface	1.9	3.8	6.6	2.6	2.6	2.1	2.1	1.7	-2.2	0.1	-0.8
Bone volume	1.2	2.4	3.9	2.0	2.0	1.8	1.8	1.4	-1.6	-0.3	-0.9
Breakpoint value in progressive ratio session	0.3	0.5	1.2	0.8	0.8	0.2	0.3	-0.1	-0.5	1.0	-1.1
Number of licking bursts	0.4	1.1	3.4	-0.3	-0.3	-0.8	-0.9	-1.8	0.9	1.0	-1.4
Context. condit. distance diff. score	0.8	1.0	3.0	-0.6	-0.6	-0.9	-0.9	0.8	1.3	0.6	-1.7
Locomotion velocity, session 1	0.7	0.7	1.6	0.8	0.8	0.8	0.7	1.2	-1.3	-0.3	0.6
Locomotion distance, session 1	0.3	0.4	1.4	-0.2	-0.2	-0.5	-0.7	0.7	-0.2	1.2	0.4
Locomotion velocity, session 2	1.8	2.2	4.8	-1.6	-1.6	-1.5	-1.8	-2.2	1.3	-0.5	0.4
Locomotion distance, session 2	0.8	1.1	3.1	-1.0	-1.0	-1.5	-1.8	-0.5	0.8	0.8	0.4
Locomotion velocity, session 3	0.8	0.9	2.8	0.6	0.6	-0.1	-0.2	1.0	0.3	1.6	-1.7
Locomotion distance, session 3	0.8	0.9	2.6	0.2	0.2	-0.5	-0.5	1.3	0.5	1.5	-1.6
Stereotopy head waving bouts, day 3	0.6	0.7	2.9	-0.6	-0.6	-0.6	-0.4	-1.7	-0.1	-0.7	0.9
Stereotopy head waving duration, day 3	1.1	1.3	5.5	-1.0	-1.0	-0.6	-0.4	-2.4	0.2	-1.2	1.1
Locomotion velocity, session 7	0.7	0.8	3.2	-0.3	-0.3	-0.8	-0.6	0.5	1.2	0.8	-1.8
Locomotion distance, session 7	1.2	1.5	3.4	-1.1	-1.1	-1.5	-1.3	1.1	1.9	0.6	-0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.4	0.4	0.4	-0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.5	0.5	0.6	0.8	0.6	-0.8	-0.4	0.1
Locomotion velocity, session 8	0.2	0.2	0.5	-0.5	-0.5	-0.6	-0.7	0.3	0.5	-0.1	-0.3
Locomotion distance, session 8	1.0	1.4	2.8	-1.1	-1.1	-1.5	-1.7	1.3	1.2	0.7	-0.4
Degree of sensitization distance	1.3	1.4	2.1	-1.5	-1.5	-1.0	-0.8	-0.6	1.4	-1.4	1.0
Degree of sensitization stereotypy	0.3	0.3	0.6	-0.6	-0.6	-0.5	-0.5	0.5	0.8	0.5	-0.4
Conditioned locomotion	1.0	1.2	3.7	-0.7	-0.7	0.6	0.4	-1.0	-0.4	-1.9	1.8
Cocaine response after cond. corrected	1.6	2.3	5.7	-1.4	-1.4	-1.7	-1.9	-0.7	1.3	2.4	-0.7
Cocaine response after cond. not corrected	0.7	1.1	2.0	-1.1	-1.1	-1.1	-1.3	-0.5	0.9	1.4	-0.6
Cocaine response before conditioning	0.7	0.8	2.9	0.7	0.7	0.9	1.2	0.2	-0.7	-1.7	0.0
Saline control response	2.9	4.1	7.8	1.5	1.5	2.5	2.7	1.5	-1.9	-2.8	1.0
Bone: connectivity density	0.5	0.8	1.6	1.1	1.1	1.2	1.1	0.1	-1.1	-0.4	-0.4
Bone: cortical apparent density	0.2	0.3	1.2	0.5	0.5	0.1	0.0	1.1	-0.1	0.3	-0.7
Bone: cortical area	1.0	1.7	2.5	1.6	1.6	1.3	1.2	0.7	-1.3	0.9	-1.5
Bone: cortical porosity	1.0	1.1	5.3	-0.3	-0.3	0.7	0.9	-1.4	0.0	-2.3	0.3
Bone: cortical porosity	1.3	1.4	6.5	-0.1	-0.1	1.1	1.3	-1.2	-0.2	-2.5	0.2
Bone: cortical thickness	1.0	1.7	2.7	-1.4	-1.4	-1.6	-1.6	-1.1	1.7	0.7	-0.5
Bone: cortical thickness	1.4	1.8	2.6	-1.6	-1.6	-1.3	-1.4	-1.5	1.6	-0.3	0.6
Bone: cortical tissue density	0.2	0.3	1.4	0.6	0.6	0.2	0.1	1.2	-0.2	0.3	-0.7
Condit. Reinf. active minus inactive responses	1.4	1.6	3.5	-1.6	-1.6	-1.0	-1.2	-0.4	1.9	-1.1	0.4
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.3	-1.4	-1.4	-0.8	-0.9	-1.1	1.5	-0.5	0.3
Condit. Reinf. active responses	1.3	1.6	3.0	-1.6	-1.6	-1.0	-1.2	1.0	1.7	-0.9	0.6
Condit. Reinf. inactive responses	0.4	0.5	3.4	-0.4	-0.4	-0.1	-0.1	1.8	0.1	0.1	-0.1
Incentive salience index mean	1.6	2.0	3.4	-1.8	-1.8	-1.1	-1.3	-0.4	1.8	-1.4	0.9
Condit. Reinf. lever presses	0.6	0.8	2.2	-1.0	-1.0	-0.5	-0.6	0.6	0.9	-1.5	0.9
Condit. Reinf. active minus inactive responses	1.1	1.6	9.4	-0.5	-0.5	0.1	0.2	-1.1	0.4	-3.1	1.3
Condit. Reinf. active-inactive response ratio	0.9	1.4	4.3	-0.9	-0.9	-0.5	-0.4	-2.1	0.8	-1.9	0.8
Condit. Reinf. active responses	1.0	1.5	7.7	0.1	0.1	0.9	0.9	0.5	-0.5	-2.8	1.3
Condit. Reinf. inactive responses	1.2	1.8	5.3	1.0	1.0	1.4	1.4	2.3	-1.4	-0.9	0.8
Condit. Reinf. lever presses	1.7	2.5	12.8	-0.2	-0.2	1.1	1.3	0.8	-0.4	-3.6	1.8
Condit. Reinf. lever reinforcers received	0.8	1.1	6.4	0.0	0.0	0.7	0.7	0.4	-0.2	-2.5	1.2
Conditioned reinforcement - actives	1.0	4.0	6.8	-2.6	-2.6	-2.2	-2.0	-1.6	2.5	-0.1	0.8
Conditioned reinforcement - inactives	0.3	0.9	2.9	-1.0	-1.0	-0.1	-0.2	1.7	1.0	-0.4	0.8
Conditioned locomotion	2.2	3.3	6.5	-2.0	-2.0	-2.5	-2.2	-0.9	2.1	1.2	0.3
Patch foraging indifference point 0 sec	1.5	4.3	7.5	2.2	2.2	2.1	2.4	2.6	-2.7	-0.1	0.3
Patch foraging indifference point AUC	0.2	0.5	2.0	0.3	0.3	0.5	0.6	-0.4	-0.7	-1.4	0.5
Delay disc. indifference point, 0s delay	1.4	1.6	3.9	2.0	2.0	0.7	0.8	0.5	-1.4	1.2	-0.7
Delay disc. indifference point, 16s delay	0.4	0.5	2.6	-0.3	-0.3	-0.5	-0.6	-1.6	-0.0	0.8	-0.2
Delay disc. indifference point, 2s delay	0.2	0.3	1.1	-0.2	-0.2	-0.5	-0.5	-0.5	0.0	-0.5	1.0
Delay disc. indifference point, 24s delay	0.5	0.9	2.2	-1.0	-1.0	-0.8	-0.9	-1.5	0.6	-0.5	0.9
Delay disc. indifference point, 4s delay	0.6	0.6	2.2	-0.6	-0.6	-0.6	-0.8	-1.5	0.0	-0.3	1.1
Delay disc. indifference point, 8s delay	0.8	1.4	2.9	-1.4	-1.4	-1.1	-1.1	-0.9	0.7	-0.9	1.7
Indifference point function ln k	0.2	0.5	2.3	0.1	0.1	-0.4	-0.4	-0.3	0.3	1.5	-1.2
Indifference point function log k	0.2	0.5	2.3	0.1	0.1	-0.4	-0.4	-0.3	0.3	1.5	-1.2
Patch foraging total patch changes 0 sec	1.8	5.2	9.2	2.5	2.5	2.3	2.6	2.9	-3.0	-0.4	0.4
Patch foraging total patch changes 12 sec	3.2	4.4	7.0	1.5	1.5	2.3	2.6	2.0	-2.7	-2.1	1.6
Patch foraging total patch changes 18 sec	0.8	1.9	2.7	1.1	1.1	1.6	1.6	1.3	-1.6	-1.5	0.8
Patch foraging total patch changes 24 sec	0.1	0.3	0.9	0.6	0.6	0.1	0.3	0.9	-0.5	-0.3	0.6
Patch foraging total patch changes 6 sec	2.1	3.5	6.3	2.0	2.0	2.0	2.3	1.9	-2.5	-0.7	0.8
Patch foraging time to switch 0 sec	0.3	1.1	2.6	-1.6	-1.6	-0.8	-1.0	-0.3	0.9	0.1	1.1
Patch foraging water rate 0 sec	0.7	2.8	5.2	2.0	2.0	1.9	2.3	-0.1	-1.9	-1.6	-0.2
Patch foraging water rate 12 sec	0.1	0.6	1.2	1.0	1.0	0.7	0.7	-1.1	-0.0	-0.5	-0.8
Patch foraging water rate 18 sec	0.7	1.7	4.0	1.7	1.7	0.7	0.9	0.0	-0.4	1.5	-2.0
Patch foraging water rate 24 sec	0.6	0.9	2.2	1.5	1.5	0.6	0.7	0.6	-0.3	0.4	-1.2
Patch foraging water rate 6 sec	0.8	1.1	2.1	1.4	1.4	1.3	1.2	-0.6	-0.6	-0.8	-0.6
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	2.5	0.1	0.1	-0.6	-0.7	-0.6	0.5	1.3	-1.6
Distance traveled before self-admin	0.9	2.1	5.4	0.3	0.3	1.5	1.4	0.8	-1.3	-2.1	2.3
Distance traveled after self-admin	0.1	0.1	0.8	-0.1	-0.1	-0.0	0.1	0.1	-0.1	-0.4	0.9
Extensor digitorum longus weight	0.3	1.1	1.7	1.3	1.3	1.3	1.1	1.0	-1.1	-0.1	-0.5
Bone: elastic displacement	0.4	0.5	1.1	-0.9	-0.9	-0.2	-0.3	-0.3	0.6	-0.9	1.1
Bone: elastic work	0.4	0.5	1.6	-0.2	-0.2	0.4	0.5	0.8	-0.4	-1.1	1.3
Bone: endosteal estimation	4.2	10.2	15.7	4.0	4.0	3.7	3.4	3.1	-3.4	0.6	-1.9
Bone: endosteal perimeter	4.2	10.4	16.8	4.1	4.1	3.7	3.5	2.2	-3.6	1.1	-2.1
Epididymis fat weight	0.1	0.6	1.7	0.6	0.6	0.7	0.7	-1.2	0.0	-1.3	-0.7
Delta time in closed arm before/after self-admin	0.3	0.3	1.0	0.3	0.3	0.6	0.6	-0.2	-0.4	-1.0	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	0.1	0.0	0.3	0.2	-0.4	-0.2	0.4
Diff in mean of infusions in LGA sessions	1.0	1.7	4.2	1.8	1.8	0.9	0.9	0.4	-0.9	0.9	-2.0
Delay discount exponential model param	1.0	1.4	3.4	1.2	1.2	1.2	1.3	1.8	-0.6	0.4	-1.2
Extinction: sum of active levers before priming	0.8	1.2	4.2	1.2	1.2	0.3	0.4	0.9	-0.6	1.1	-2.1
Active lever presses in extinction session 6	1.3	1.3	5.1	0.6	0.6	-0.3	-0.5	-0.1	0.2	2.1	-2.3
Bone: final force	0.5	0.7	2.2	1.2	1.2	0.3	0.4	0.3	-0.5	0.7	-1.5
Bone: final moment	0.6	0.9	2.4	1.3	1.3	0.4	0.6	0.5	-0.7	0.7	-1.5
Food consumed during 24 hour testing period	2.3	4.6	14.5	2.8	2.8	0.7	0.7	-0.1	-0.3	2.5	-3.8
Glucose	0.8	1.2	5.2	0.8	0.8	0.4	-0.0	-2.3	0.0	0.5	-1.7
Heart weight	0.2	0.3	1.2	-0.3	-0.3	-0.2	0.0	-1.1	0.4	-1.1	0.1
Delay discount hyperbolic model param	1.1	1.4	2.8	1.1	1.1	1.2	1.3	1.7	-0.5	0.5	-1.4
Intermittent access intake day 1-15 change	0.0	0.2	0.6	0.0	0.0	0.5	0.5	0.7	0.1	-0.6	0.7
Intermittent access intake escalation	0.0	0.2	0.4	0.1	0.1	0.4	0.4	0.6	0.1	-0.4	0.6
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	0.1	0.4	0.5	0.1	0.1	-0.5	0.3
Intermitt. access day 1 inactive lever presses	0.1	0.7	2.2	0.1	0.1	1.0	0.7	-0.2	-0.7	-1.0	1.5
Intermitt. access day 15 inactive lever presses	0.1	0.8	2.0	-0.8	-0.8	-1.1	-1.1	0.4	1.4	0.2	0.3
Intermitt. access escalation Index	0.1	0.5	1.8	-0.4	-0.4	0.8	0.7	1.4	-0.6	-0.4	-0.1
Intermittent access day 1 total infusions	0.6	1.7	2.9	-1.7	-1.7	-1.5	-1.5	-0.5	1.6	0.7	-0.3
Intermittent access day 15 total infusions	0.3	0.8	1.9	-1.1	-1.1	-0.7	-0.8	0.7	1.4	0.3	-0.0
Intermittent access terminal intake (last 3 days)	0.8	1.4	3.0	-1.3	-1.3	-1.2	-1.2	-0.1	1.7	1.1	-0.7
Intermittent access total infusions	1.4	1.7	3.6	-1.6	-1.6	-1.5	-1.4	0.4	1.9	0.7	-0.2
Intermittent access day 1 locomotion	1.3	2.4	3.5	-1.8	-1.8	-1.9	-1.8	-1.1	1.8	1.0	-0.1
Intermittent access day 15 total locomotion	0.6	2.2	4.1	-1.5	-1.5	-2.0	-1.9	0.1	2.0	1.1	0.3
Intermittent access total locomotion	1.9	2.2	4.1	-1.9	-1.9	-1.8	-1.7	-0.4	2.0	0.4	0.5
Intermittent access standard deviation	0.4	2.0	4.7	-1.8	-1.8	-0.9	-0.7	0.7	1.5	-1.1	2.2
Left kidney weight	0.6	4.5	7.8	2.6	2.6	2.6	2.8	1.2	-1.8	-1.0	-1.5
Right kidney weight	0.4	3.0	4.7	2.1	2.1	2.1	2.2	1.1	-1.1	-1.1	-1.5
Cocaine induced anxiety	1.4	3.9	21.4	1.5	1.5	1.2	1.2	4.6	-0.3	1.1	-0.8
Post-drug Anxiety	1.3	1.5	9.5	0.6	0.6	0.7	0.6	3.1	-0.2	0.9	0.2
Baseline Anxiety	1.3	2.2	7.3	-1.6	-1.6	-1.0	-1.2	-2.7	0.2	-1.0	1.3
Tail length	0.1	0.7	1.3	0.8	0.8	1.1	1.1	0.7	-0.7	-0.6	-0.1
Length with tail	0.9	4.0	7.7	1.9	1.9	2.8	2.7	1.5	-2.0	-1.9	0.2
Length without tail	0.4	2.0	3.5	1.4	1.4	1.9	1.8	1.2	-1.2	-1.6	0.4
Times rat made contact with spout	0.4	0.4	1.4	0.7	0.7	0.4	0.7	-0.2	-0.3	-0.4	-1.2
Lifetime Intake	1.6	1.9	3.7	-1.4	-1.4	-1.7	-1.7	-0.1	1.9	1.2	-0.6
Liver weight, left	3.6	6.2	10.7	2.7	2.7	3.3	3.1	1.3	-3.1	-1.9	0.4
Liver weight, right	2.5	4.4	6.9	2.5	2.5	2.5	2.3	2.6	-2.0	-0.4	-0.6
Locomotor activity	3.1	4.9	9.7	2.9	2.9	1.1	1.3	3.1	-1.9	2.1	-1.2
Locomotor testing distance	2.1	5.2	16.7	2.7	2.7	1.4	1.5	4.1	-1.9	1.6	-0.7
Locomotor testing rearing	0.4	1.4	5.5	1.0	1.0	0.1	0.0	2.3	0.1	1.9	-0.5
Locomotion in novel chamber	0.3	0.5	1.3	0.6	0.6	0.5	0.6	1.1	-0.5	-0.8	-0.3
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	-0.1	-0.1	-0.4	-0.6	-0.7	0.2	0.2	0.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.2	0.2	-0.2	-0.3	-0.4	-0.3	0.0	0.2
Change in fecal boli incidents, locomotor task	0.6	0.6	1.5	-0.7	-0.7	-0.8	-0.8	0.7	0.9	1.2	-0.0
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.8	-0.7	-0.7	-1.1	-1.2	-1.0	1.3	0.8	-0.9
Bouts of movement, locomotor time 1	0.6	0.7	2.2	0.3	0.3	0.4	0.8	0.1	-0.8	-1.4	1.5
Total resting periods, locomotor time 1	0.5	0.6	1.6	0.3	0.3	0.3	0.8	-0.0	-0.8	-1.3	1.2
Rest time, locomotor task time 1	0.3	0.4	1.9	0.4	0.4	0.1	0.5	-1.4	-0.2	0.2	-0.8
Distance moved, locomotor task time 1	0.1	0.2	0.5	-0.3	-0.3	0.1	-0.0	0.6	-0.3	-0.4	0.7
Vertical activity count, locomotor time 1	0.1	0.4	0.7	-0.8	-0.8	-0.4	-0.5	-0.3	0.2	-0.7	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	-0.4	-0.4	-0.6	-0.8	-0.1	0.5	0.3	0.1
Bouts of movement, locomotor time 2	0.2	0.7	1.4	0.7	0.7	0.8	0.9	1.2	-0.6	-0.9	0.8
Total resting periods, locomotor time 2	0.2	0.9	1.3	1.0	1.0	1.0	1.1	1.1	-0.8	-0.9	0.6
Rest time, locomotor task time 2	0.3	0.5	3.7	0.1	0.1	-0.0	0.1	-1.9	-0.1	0.0	-0.7
Distance moved, locomotor task time 2	0.4	0.5	2.2	-0.0	-0.0	0.4	0.3	1.5	-0.4	-0.4	1.1
Vertical activity count, locomotor time 2	0.0	0.1	0.3	0.0	0.0	-0.2	-0.2	0.5	0.0	0.5	0.1
Light reinforcement 1	0.4	1.8	6.2	1.6	1.6	0.9	1.0	0.1	-0.5	1.0	-2.5
Light reinforcement 2	0.3	0.6	2.2	-0.2	-0.2	-0.5	-0.7	-0.7	0.6	1.5	-0.9
Bone: marrow area	4.1	10.1	15.6	4.0	4.0	3.7	3.4	3.0	-3.4	0.6	-1.9
Bone: maximum diameter	5.8	11.6	19.4	4.4	4.4	3.8	3.6	1.6	-3.9	1.4	-2.6
Bone: maximum force	0.3	0.6	1.6	0.9	0.9	0.3	0.4	0.6	-0.5	0.6	-1.3
Bone: maximum moment	0.4	0.7	1.8	1.0	1.0	0.4	0.5	0.8	-0.7	0.6	-1.3
Mean time between licks in bursts	0.2	1.3	5.6	-0.4	-0.4	-1.2	-1.2	2.4	0.8	1.0	-0.0
Mean num. licks in bursts	0.6	1.6	3.3	1.0	1.0	1.3	1.5	1.8	-1.2	-1.2	0.6
Cd content in liver	1.4	1.6	3.4	0.7	0.7	1.8	1.7	0.8	-1.7	-1.2	0.5
Co content in liver	1.9	2.3	3.8	1.9	1.9	1.3	1.1	1.8	-1.3	1.3	-1.0
Cu content in liver	1.1	1.3	5.5	-1.3	-1.3	-0.4	-0.5	0.4	-0.1	-0.7	2.4
Fe content in liver	0.4	0.5	0.9	-0.9	-0.9	-0.4	-0.7	-0.8	0.7	0.1	0.5
K content in liver	0.9	0.9	2.9	-0.9	-0.9	-0.2	0.1	0.3	0.3	-1.6	1.7
Mg content in liver	0.4	0.5	1.0	0.3	0.3	0.6	0.7	0.7	-0.7	-0.9	1.0
Mn content in liver	3.2	3.6	11.1	-2.2	-2.2	-0.5	-0.6	-0.7	0.1	-2.7	3.3
Na content in liver	1.9	2.1	9.7	0.7	0.7	1.2	1.3	3.1	-1.0	-0.7	1.4
Rb content in liver	0.5	0.5	1.0	0.9	0.9	0.6	0.8	0.2	-1.0	0.7	0.1
Se content in liver	1.2	1.4	4.7	-1.0	-1.0	0.4	0.3	-1.1	-0.1	-2.2	1.8
Sr content in liver	0.2	0.2	0.6	-0.7	-0.7	0.1	0.0	0.1	-0.5	-0.3	0.2
Zn content in liver	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2	-0.3	-0.2	-0.4	0.1
Bone: minimum diameter	0.8	1.5	2.2	1.4	1.4	1.4	1.3	0.5	-1.3	0.1	-1.5
Time in familiar zone, hab. session 1	1.9	2.1	3.0	1.7	1.7	1.5	1.4	1.3	-0.9	1.4	-1.6
Time in novel zone, hab. session 1	0.7	0.8	1.8	-1.1	-1.1	-0.7	-0.7	-0.6	0.5	-1.3	0.9
Total zone transitions, hab. session 1	0.0	0.1	0.2	0.1	0.1	-0.0	-0.2	0.1	-0.4	0.4	-0.1
Total locomotion distance, hab. session 1	0.6	0.8	2.0	-1.0	-1.0	-1.3	-1.4	0.1	0.9	0.5	0.1
Locomotion velocity, hab. session 1	0.4	0.6	1.5	-0.7	-0.7	-1.1	-1.2	0.2	0.7	0.5	0.3
Time in familiar zone, hab. session 2	1.3	1.5	3.0	1.7	1.7	0.9	0.7	0.9	-0.5	1.3	-1.2
Time in novel zone, hab. session 2	0.5	0.5	1.0	-1.0	-1.0	-0.6	-0.5	-0.7	0.1	-0.7	0.7
Total zone transitions, hab. session 2	0.6	0.7	4.2	0.1	0.1	0.4	0.2	2.1	-0.8	0.3	0.8
Total locomotion distance, hab. session 2	0.5	0.7	1.3	-0.9	-0.9	-0.7	-0.9	0.9	0.2	0.3	1.1
Locomotion velocity, hab. session 2	0.4	0.6	1.8	-0.7	-0.7	-0.4	-0.6	1.1	-0.0	-0.0	1.3
Novel to familiar place preference ratio	0.9	1.2	3.5	-0.9	-0.9	-0.6	-0.3	1.9	0.2	-0.9	1.9
Novelty place preference	0.8	1.0	3.4	-0.7	-0.7	-0.5	-0.2	1.8	0.1	-0.8	1.6
Time in novel zone, NPP test	0.8	0.9	4.3	-0.3	-0.3	-0.3	-0.0	2.1	-0.2	-0.8	1.5
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	-0.3	-0.4	-0.4	-0.2	-0.3	0.3	0.3
Total locomotion distance, NPP test	0.5	0.7	1.2	-1.1	-1.1	-0.9	-0.9	-0.4	0.4	0.1	1.1
Locomotion velocity, NPP test	0.8	1.1	1.9	-1.4	-1.4	-1.2	-1.2	-0.5	0.8	0.1	1.2
Intraocular pressure	1.5	2.4	6.4	1.8	1.8	0.7	0.4	2.5	-0.8	1.8	-1.4
Delta distance traveled before/after self-admin	1.4	1.5	5.7	-0.0	-0.0	-1.3	-1.1	0.1	0.8	2.4	-1.7
Delta ambulatory time before/after self-admin	0.7	1.1	4.1	0.2	0.2	-1.0	-0.8	-0.3	0.7	2.0	-1.6
Parametrial fat weight	0.6	1.5	5.3	0.6	0.6	1.2	1.4	-0.0	-0.8	-2.3	1.3
Pavlov. Cond. lever latency	0.5	0.6	3.0	-0.4	-0.4	-0.6	-0.7	-0.7	0.3	1.7	-0.1
Pavlov. Cond. magazine entry latency	1.4	1.7	2.6	1.2	1.2	1.6	1.6	1.5	-1.6	-0.9	-0.0
Pavlov. Cond. change in total contacts	1.1	1.2	2.6	0.9	0.9	1.2	1.4	1.6	-1.0	-1.0	-0.2
Pavlov. Cond. index score	1.0	1.3	1.9	1.1	1.1	1.3	1.4	1.3	-1.2	-1.1	-0.3
Pavlov. Cond. latency score	1.1	1.4	2.1	1.2	1.2	1.3	1.4	1.4	-1.1	-1.1	-0.4
Pavlov. Cond. lever contacts	0.9	1.1	3.6	0.8	0.8	1.1	1.2	1.0	-0.7	-1.9	0.0
Pavlov. Cond. magazine entry number	0.7	0.9	1.7	-0.6	-0.6	-1.1	-1.1	-1.3	1.1	0.9	-0.0
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.9	-1.4	-1.4	-0.5	-0.6	0.3	0.7	-1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.9	1.1	1.1	1.3	1.4	1.3	-1.2	-1.3	-0.1
Pavlov. Cond. response bias	0.5	0.6	2.0	0.4	0.4	0.9	0.9	0.8	-0.6	-1.4	0.1
Pavlov. Cond. lever latency	1.4	2.0	3.6	-1.0	-1.0	-1.7	-1.8	-1.2	1.6	1.9	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	0.4	0.1	0.1	-0.1	-0.2	0.4	-0.5
Pavlov. Cond. change in total contacts	0.3	0.8	2.7	0.2	0.2	0.8	0.9	1.6	-0.7	-1.0	0.9
Pavlov. Cond. index score	0.7	1.1	1.7	0.9	0.9	1.3	1.3	1.2	-1.2	-0.9	0.4
Pavlov. Cond. latency score	0.5	0.7	1.2	0.9	0.9	1.0	1.0	1.1	-1.0	-0.3	0.2
Pavlov. Cond. lever contacts	1.7	2.5	4.2	1.3	1.3	2.0	2.0	1.4	-1.8	-1.9	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	-0.9	-0.9	-0.4	-0.5	-0.3	0.5	-0.8	1.1
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.8	-1.4	-1.4	-0.8	-1.1	-0.7	1.7	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.5	0.8	0.8	1.1	1.2	1.2	-1.1	-0.8	0.4
Pavlov. Cond. response bias	1.2	1.6	4.5	0.7	0.7	1.5	1.6	0.8	-1.3	-2.1	0.8
Time in closed arm before self-admin	0.1	0.1	0.5	0.1	0.1	0.4	0.3	-0.3	-0.3	0.7	-0.5
Time in closed arm after self-admin	0.1	0.1	0.4	-0.0	-0.0	0.6	0.3	-0.0	-0.0	-0.1	-0.2
Time in open arm before self-admin	0.4	0.5	1.2	-0.6	-0.6	-1.1	-1.1	-0.2	0.8	-0.3	0.7
Time in open arm after self-admin	0.2	0.2	0.8	-0.3	-0.3	-0.9	-0.7	-0.4	0.3	0.1	0.4
Bone: periosteal estimation	3.8	9.1	14.3	3.8	3.8	3.3	3.1	2.6	-3.2	1.1	-2.4
Bone: periosteal perimeter	3.3	6.4	9.8	3.1	3.1	2.9	2.8	1.5	-2.8	0.9	-2.2
Bone: post-yield work	0.5	0.8	1.7	1.2	1.2	0.6	0.6	0.2	-1.3	0.5	-0.8
Progressive ratio test 1 active lever presses	1.0	1.7	2.4	-1.5	-1.5	-1.4	-1.3	-1.4	1.6	0.8	-0.4
Progressive ratio test 1 breakpoint	0.9	1.5	2.3	-1.5	-1.5	-1.3	-1.2	-1.3	1.5	0.7	-0.3
Progressive ratio test 1 inactive lever presses	1.0	2.7	5.5	-2.3	-2.3	-1.7	-1.6	-1.2	1.7	-0.4	1.0
Progressive ratio test 2 active lever presses	1.3	1.8	4.7	-1.6	-1.6	-1.2	-1.4	-0.9	2.2	0.2	-0.2
Progressive ratio test 2 breakpoint	1.4	1.8	4.7	-1.5	-1.5	-1.3	-1.4	-1.0	2.2	0.3	-0.4
Progressive ratio test 2 inactive lever presses	0.6	1.8	4.0	-1.9	-1.9	-1.1	-1.1	-0.2	2.0	0.3	0.0
Incentive Sensitization - Responses	0.2	0.5	1.2	-0.9	-0.9	0.0	-0.3	0.6	1.1	-0.8	0.4
Incentive Sensitization - Breakpoint	0.3	0.6	1.5	-0.9	-0.9	-0.1	-0.3	0.5	1.2	-0.9	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.4	-0.4	-0.5	-0.5	0.0	0.4	0.5	0.2
Progressive ratio	0.3	0.9	3.5	0.9	0.9	0.7	0.7	1.9	-0.8	0.5	-0.5
Food seeking constrained by brief footshock	0.1	0.2	0.6	0.1	0.1	-0.1	-0.4	0.4	0.4	0.8	-0.5
Seeking ratio, punishment vs. effort	0.7	1.6	4.0	-1.2	-1.2	-1.3	-1.5	-2.0	1.5	0.1	0.2
Retroperitoneal fat weight	0.4	1.9	7.1	-1.0	-1.0	-0.0	0.0	-2.7	0.7	-2.1	1.1
Reaction time number correct	3.3	11.6	20.8	4.1	4.1	4.6	4.3	1.5	-3.8	-0.5	-1.9
Reaction time mean minus median	0.1	0.5	3.3	-0.3	-0.3	0.1	0.4	-1.8	-0.2	-0.6	0.4
Reaction time mean minus median AUC	0.1	1.0	5.3	-0.7	-0.7	-0.1	0.1	-2.3	0.0	-1.0	0.7
Reaction time num false alarms	0.8	1.4	3.1	0.4	0.4	1.3	1.4	1.8	-1.3	-1.2	1.0
Reaction time num false alarms AUC	0.9	2.1	4.8	0.7	0.7	1.6	1.7	2.2	-1.5	-1.5	0.8
Reaction time trials correct on left	3.3	11.6	20.8	4.1	4.1	4.6	4.3	1.5	-3.8	-0.5	-1.9
Reaction time trials on left	3.4	11.4	20.5	4.0	4.0	4.5	4.3	1.4	-3.7	-0.5	-1.9
Reaction time mean	1.1	2.4	6.0	-1.4	-1.4	-1.8	-1.5	-2.4	1.7	1.0	-0.4
Reaction time mean AUC	0.8	1.8	4.9	-1.0	-1.0	-1.5	-1.3	-2.2	1.4	1.2	-0.7
Median of all reaction times	1.9	3.0	4.4	-1.7	-1.7	-2.1	-1.9	-1.9	2.1	1.5	-0.6
Reaction time omissions	0.3	0.5	3.1	-0.5	-0.5	-0.3	-0.2	-1.8	0.3	-0.2	0.4
Reaction time false alarm rate	1.1	1.6	3.1	-1.6	-1.6	-1.0	-0.8	1.0	0.7	-1.2	1.8
Reaction time premature initiation rate	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.4	0.3	0.2	0.6	-0.4
Reaction time premature initiations	0.6	2.0	3.4	1.5	1.5	1.8	1.7	0.9	-1.6	0.3	-1.3
Std. dev. reaction times	0.7	2.3	12.4	-1.3	-1.3	-0.9	-0.5	-3.5	0.7	-0.7	0.5
Reaction time trials completed	3.4	11.4	20.5	4.0	4.0	4.5	4.3	1.4	-3.7	-0.5	-1.9
Reaction time trials AUC	3.2	11.2	20.5	4.0	4.0	4.5	4.3	1.4	-3.7	-0.7	-1.7
Run reversals in cocaine runway, females	1.4	1.6	5.8	0.2	0.2	-1.2	-1.1	0.3	0.8	2.4	-1.9
Run reversals in cocaine runway, males	0.8	0.8	1.6	-1.0	-1.0	-1.3	-1.2	-0.6	1.0	-0.3	0.4
Latency to leave start box in cocaine runway	0.3	0.4	0.6	0.8	0.8	0.4	0.4	-0.7	-0.7	0.7	-0.3
Latency to leave start box in cocaine runway, F	0.8	1.0	1.5	1.2	1.2	1.0	1.0	0.1	-1.0	0.9	-1.0
Latency to leave start box in cocaine runway, M	1.5	1.4	3.7	-1.1	-1.1	-1.3	-1.5	-1.9	0.7	0.1	0.9
Std. dev. time between licks in bursts	0.3	0.5	1.4	0.7	0.7	-0.2	-0.5	1.1	-0.2	1.2	-0.1
Total sessions with >9 infusions	3.9	4.8	7.4	-2.2	-2.2	-2.6	-2.7	-2.4	2.6	1.4	-0.6
Short access day 1 total inactive lever presses	0.4	0.8	2.0	-1.1	-1.1	-0.8	-1.0	0.0	1.4	0.3	-0.1
Short access day 10 total inactive lever presses	0.1	0.4	1.2	-0.7	-0.7	0.0	-0.2	-0.2	0.4	-0.8	1.1
Short access day 1 total infusions	1.8	3.6	5.6	-2.0	-2.0	-2.1	-2.4	-2.3	2.0	1.0	-0.3
Short access day 10 total infusions	0.7	1.2	2.3	-1.1	-1.1	-1.5	-1.4	-0.7	1.0	1.1	0.1
Short access total infusions	3.1	4.3	7.5	-2.1	-2.1	-2.6	-2.7	-1.7	2.4	1.7	-0.6
Short access day 1 locomotion	1.3	2.1	7.1	-1.2	-1.2	-1.5	-1.4	-2.7	1.0	1.0	-0.6
Short access day 10 total locomotion	0.3	1.4	4.3	-1.2	-1.2	-0.7	-0.6	-1.2	0.4	-1.1	2.1
Short access total locomotion	3.1	4.7	7.0	-2.6	-2.6	-2.5	-2.4	-2.6	2.1	0.4	1.0
One hour access (0.3 mA shock)	1.1	1.3	2.8	-1.7	-1.7	-0.8	-1.0	-0.5	0.9	-1.0	1.0
Compulsive drug intake	3.0	4.5	12.6	0.5	0.5	2.8	2.6	0.0	-2.3	-3.5	1.7
One hour access (shock baseline)	0.8	2.1	3.8	-1.4	-1.4	-1.9	-2.0	0.1	1.9	1.2	-0.4
Social response proportion	0.5	0.7	1.8	0.7	0.7	0.3	0.4	0.7	-0.3	1.2	-1.3
Social responses	0.5	0.7	3.1	0.6	0.6	-0.2	-0.1	-0.1	-0.5	1.8	-1.2
Social time	0.1	0.2	1.1	-0.3	-0.3	0.1	-0.1	-0.3	0.1	0.6	-1.0
Soleus weight	6.3	18.5	31.4	5.0	5.0	4.5	4.4	5.6	-5.1	0.1	0.4
Bone: stiffness	0.4	0.8	1.5	1.2	1.2	0.4	0.6	0.8	-0.9	0.7	-1.0
Tibialis anterior weight	4.0	13.7	22.3	3.8	3.8	4.7	4.7	3.4	-4.2	-2.4	-0.9
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	-0.2	-0.2	-0.4	-0.4	0.2	0.6	0.6	-0.5
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.1	-0.6	-0.6	-0.5	-0.7	0.5	1.1	0.5	-0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.2	0.2	0.0	-0.3	-0.4	0.5	0.4	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	1.1	0.2	0.2	0.1	0.2	-0.3	-0.4	-0.8	1.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	-0.9	-0.9	-0.7	-0.8	-0.3	1.0	-0.1	0.0
Delta time to tail flick, test, before/after SA	0.3	0.4	1.1	-0.6	-0.6	-0.3	-0.0	-0.4	-0.4	-1.1	1.1
Tibia length	2.4	6.5	10.5	3.0	3.0	3.2	3.2	1.8	-2.7	-1.0	-1.5
Ambulatory time before self-admin	0.4	1.2	4.5	-0.3	-0.3	0.7	0.6	0.4	-0.6	-1.8	2.1
Ambulatory time after self-admin	0.0	0.1	0.4	-0.0	-0.0	-0.3	-0.1	-0.1	-0.0	0.3	0.6
Bone: tissue strength	0.4	0.5	2.7	-0.0	-0.0	0.1	0.4	1.6	-0.5	-0.7	0.4
Total heroin consumption	0.2	0.2	0.7	0.3	0.3	-0.5	-0.2	-0.3	-0.1	0.8	-0.6
Bone: trabecular number	1.6	3.0	5.5	2.1	2.1	2.3	2.2	0.8	-1.9	-0.4	-0.9
Bone: trabecular spacing	0.4	0.5	1.6	-0.7	-0.7	-0.1	-0.2	1.2	0.0	-0.5	1.2
Bone: trabecular thickness	0.2	0.3	1.2	0.2	0.2	0.3	0.5	-1.1	-0.1	-0.8	-0.3
Bone: trabecular tissue density	0.1	0.1	0.5	0.3	0.3	0.3	0.1	0.7	-0.1	0.0	-0.1
Water consumed over 24 hours	1.9	3.7	7.2	2.7	2.7	1.9	2.1	-0.4	-1.5	-0.0	-2.2
Number of responses in last shaping day	6.8	8.8	12.8	-3.3	-3.3	-3.6	-3.6	-3.3	3.4	0.5	0.6