Hub : Genes

Runx1t1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS XM_008763550.4 0.03 0.03 3.1e-03 0.02 0.01 0.01 0.01 4.6e-03 4.0e-02 6.9e-02 1.7e-02
2 Adipose alternative TSS XM_008763550.4 0.04 0.03 1.7e-03 0.02 0.01 0.01 0.01 2.6e-03 2.3e-02 2.3e-02 8.2e-03
3 NAcc alternative polyA XM_006237901.5 0.01 0.01 5.9e-03 0.01 0.01 0.01 0.01 4.3e-03 1.2e-02 9.5e-03 7.0e-03
4 PL mRNA stability Runx1t1 0.06 0.05 7.4e-04 0.03 0.02 0.03 0.03 1.1e-04 3.3e-03 3.3e-04 2.0e-04
5 Adipose isoform ratio XM_006237901.5 0.02 0.01 6.1e-03 0.01 0 0.01 0.01 9.7e-03 9.3e-02 2.1e-02 2.9e-02
6 NAcc mRNA stability Runx1t1 0.05 0.03 7.7e-07 0.04 0.04 0.04 0.04 1.7e-06 8.4e-07 2.3e-07 4.4e-06
7 NAcc gene expression Runx1t1 0.04 0.03 3.1e-03 0.02 0.01 0.01 0.02 2.4e-04 2.6e-03 7.0e-03 1.4e-03
8 IC isoform ratio NM_001108657.1 0.15 0.1 2.7e-03 0.01 0.06 0.03 0.04 7.4e-02 1.8e-03 2.0e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.32.23.4-1.8-1.8-1.8-1.71.50.40.3-1.4
Area under the delay curve0.91.02.90.90.91.11.2-0.51.70.10.9
BMI with tail2.06.812.1-3.5-3.5-2.9-2.92.7-2.20.8-0.6
BMI without tail1.34.08.4-2.9-2.9-2.1-2.12.0-0.6-0.0-1.4
Body weight2.29.516.5-3.4-3.4-4.1-3.92.9-2.72.3-0.0
Weight adjusted by age0.50.71.3-0.8-0.8-1.1-1.11.1-0.30.60.4
Bone surface2.03.66.6-2.6-2.6-2.1-2.12.2-1.0-0.1-0.8
Bone volume1.32.33.9-2.0-2.0-1.8-1.81.6-0.80.3-0.9
Breakpoint value in progressive ratio session0.40.51.2-0.8-0.8-0.2-0.30.50.6-1.0-1.1
Number of licking bursts0.71.24.10.30.30.80.9-0.92.0-1.0-1.4
Context. condit. distance diff. score0.91.13.00.60.60.90.9-1.3-1.1-0.6-1.7
Locomotion velocity, session 10.60.71.6-0.8-0.8-0.8-0.71.3-1.00.30.6
Locomotion distance, session 10.30.41.40.20.20.50.70.2-0.9-1.20.4
Locomotion velocity, session 21.92.24.51.61.61.51.8-1.32.10.50.4
Locomotion distance, session 20.81.13.11.01.01.51.8-0.80.2-0.80.4
Locomotion velocity, session 30.81.02.8-0.6-0.60.10.2-0.3-1.2-1.6-1.7
Locomotion distance, session 30.91.02.6-0.2-0.20.50.5-0.5-1.5-1.5-1.6
Stereotopy head waving bouts, day 30.60.73.00.60.60.60.40.11.70.70.9
Stereotopy head waving duration, day 31.21.45.91.01.00.60.4-0.22.41.21.1
Locomotion velocity, session 70.80.83.20.30.30.80.6-1.2-0.6-0.8-1.8
Locomotion distance, session 71.41.83.51.11.11.51.3-1.9-1.9-0.6-0.7
Stereotopy head waving bouts, day 70.10.20.20.40.40.30.3-0.4-0.5-0.4-0.4
Stereotopy head waving duration, day 70.30.30.7-0.5-0.5-0.6-0.80.8-0.20.40.1
Locomotion velocity, session 80.20.20.50.50.50.60.7-0.5-0.50.1-0.3
Locomotion distance, session 81.21.73.81.11.11.51.7-1.2-2.0-0.7-0.4
Degree of sensitization distance1.31.42.11.51.51.00.8-1.40.11.41.0
Degree of sensitization stereotypy0.30.40.60.60.60.50.5-0.8-0.7-0.5-0.4
Conditioned locomotion1.01.23.70.70.7-0.6-0.40.40.91.91.8
Cocaine response after cond. corrected1.92.35.71.41.41.71.9-1.30.4-2.4-0.7
Cocaine response after cond. not corrected0.91.02.01.11.11.11.3-0.90.2-1.4-0.6
Cocaine response before conditioning0.70.82.9-0.7-0.7-0.9-1.20.70.01.70.0
Saline control response2.93.97.8-1.5-1.5-2.5-2.71.9-1.12.81.0
Bone: connectivity density0.50.81.6-1.1-1.1-1.2-1.11.10.40.4-0.4
Bone: cortical apparent density0.20.20.6-0.5-0.5-0.1-0.00.1-0.8-0.3-0.7
Bone: cortical area1.11.62.5-1.6-1.6-1.3-1.21.3-0.3-0.9-1.5
Bone: cortical porosity1.11.25.30.30.3-0.7-0.9-0.01.62.30.3
Bone: cortical porosity1.41.56.50.10.1-1.1-1.30.21.52.50.2
Bone: cortical thickness1.01.62.71.41.41.61.6-1.70.7-0.7-0.5
Bone: cortical thickness1.31.62.61.61.61.31.4-1.60.90.30.6
Bone: cortical tissue density0.20.30.8-0.6-0.6-0.2-0.10.2-0.9-0.3-0.7
Condit. Reinf. active minus inactive responses1.41.63.51.61.61.01.2-1.9-0.21.10.4
Condit. Reinf. active-inactive response ratio1.01.12.31.41.40.80.9-1.50.70.50.3
Condit. Reinf. active responses1.61.93.51.61.61.01.2-1.7-1.90.90.6
Condit. Reinf. inactive responses0.60.75.10.40.40.10.1-0.1-2.3-0.1-0.1
Incentive salience index mean1.62.03.41.81.81.11.3-1.8-0.41.40.9
Condit. Reinf. lever presses0.70.92.21.01.00.50.6-0.9-1.01.50.9
Condit. Reinf. active minus inactive responses1.31.69.40.50.5-0.1-0.2-0.41.03.11.3
Condit. Reinf. active-inactive response ratio1.21.44.50.90.90.50.4-0.82.11.90.8
Condit. Reinf. active responses1.11.57.7-0.1-0.1-0.9-0.90.5-0.52.81.3
Condit. Reinf. inactive responses1.51.96.0-1.0-1.0-1.4-1.41.4-2.40.90.8
Condit. Reinf. lever presses1.82.512.80.20.2-1.1-1.30.4-0.93.61.8
Condit. Reinf. lever reinforcers received0.81.16.4-0.0-0.0-0.7-0.70.2-0.42.51.2
Conditioned reinforcement - actives2.23.76.82.62.62.22.0-2.50.50.10.8
Conditioned reinforcement - inactives0.91.46.91.01.00.10.2-1.0-2.60.40.8
Conditioned locomotion2.53.26.52.02.02.52.2-2.1-0.0-1.20.3
Patch foraging indifference point 0 sec2.24.07.5-2.2-2.2-2.1-2.42.7-2.20.10.3
Patch foraging indifference point AUC0.40.62.0-0.3-0.3-0.5-0.60.71.01.40.5
Delay disc. indifference point, 0s delay1.51.63.9-2.0-2.0-0.7-0.81.4-0.1-1.2-0.7
Delay disc. indifference point, 16s delay0.60.63.60.30.30.50.60.01.9-0.8-0.2
Delay disc. indifference point, 2s delay0.20.21.10.20.20.50.5-0.00.40.51.0
Delay disc. indifference point, 24s delay0.70.81.51.01.00.80.9-0.61.20.50.9
Delay disc. indifference point, 4s delay0.60.62.00.60.60.60.8-0.01.40.31.1
Delay disc. indifference point, 8s delay1.11.32.91.41.41.11.1-0.70.40.91.7
Indifference point function ln k0.30.52.3-0.1-0.10.40.4-0.30.1-1.5-1.2
Indifference point function log k0.30.52.3-0.1-0.10.40.4-0.30.1-1.5-1.2
Patch foraging total patch changes 0 sec2.64.99.2-2.5-2.5-2.3-2.63.0-2.40.40.4
Patch foraging total patch changes 12 sec3.24.17.0-1.5-1.5-2.3-2.62.7-1.42.11.6
Patch foraging total patch changes 18 sec1.21.82.7-1.1-1.1-1.6-1.61.6-1.01.50.8
Patch foraging total patch changes 24 sec0.10.30.6-0.6-0.6-0.1-0.30.5-0.80.30.6
Patch foraging total patch changes 6 sec2.23.36.3-2.0-2.0-2.0-2.32.5-1.30.70.8
Patch foraging time to switch 0 sec0.51.12.61.61.60.81.0-0.9-0.2-0.11.1
Patch foraging water rate 0 sec1.42.95.2-2.0-2.0-1.9-2.31.91.01.6-0.2
Patch foraging water rate 12 sec0.30.71.7-1.0-1.0-0.7-0.70.01.30.5-0.8
Patch foraging water rate 18 sec1.11.74.0-1.7-1.7-0.7-0.90.40.2-1.5-2.0
Patch foraging water rate 24 sec0.60.92.2-1.5-1.5-0.6-0.70.3-0.5-0.4-1.2
Patch foraging water rate 6 sec0.81.22.1-1.4-1.4-1.3-1.20.61.20.8-0.6
Seeking ratio, delayed vs. immediate footshock0.60.82.5-0.1-0.10.60.7-0.51.0-1.3-1.6
Distance traveled before self-admin1.62.15.4-0.3-0.3-1.5-1.41.3-1.12.12.3
Distance traveled after self-admin0.10.10.80.10.10.0-0.10.1-0.10.40.9
Extensor digitorum longus weight0.31.01.7-1.3-1.3-1.3-1.11.1-0.60.1-0.5
Bone: elastic displacement0.40.51.10.90.90.20.3-0.6-0.20.91.1
Bone: elastic work0.50.61.60.20.2-0.4-0.50.4-1.21.11.3
Bone: endosteal estimation4.49.615.7-4.0-4.0-3.7-3.43.4-2.2-0.6-1.9
Bone: endosteal perimeter4.710.016.8-4.1-4.1-3.7-3.53.6-1.4-1.1-2.1
Epididymis fat weight0.20.82.9-0.6-0.6-0.7-0.7-0.01.71.3-0.7
Delta time in closed arm before/after self-admin0.30.31.0-0.3-0.3-0.6-0.60.40.41.00.3
Delta time in open arm before/after self-admin0.10.10.2-0.1-0.1-0.0-0.30.4-0.20.20.4
Diff in mean of infusions in LGA sessions1.41.74.2-1.8-1.8-0.9-0.90.90.2-0.9-2.0
Delay discount exponential model param1.21.32.8-1.2-1.2-1.2-1.30.6-1.7-0.4-1.2
Extinction: sum of active levers before priming1.01.14.2-1.2-1.2-0.3-0.40.6-0.1-1.1-2.1
Active lever presses in extinction session 61.41.45.1-0.6-0.60.30.5-0.20.6-2.1-2.3
Bone: final force0.50.72.2-1.2-1.2-0.3-0.40.50.0-0.7-1.5
Bone: final moment0.50.92.4-1.3-1.3-0.4-0.60.7-0.2-0.7-1.5
Food consumed during 24 hour testing period3.54.814.5-2.8-2.8-0.7-0.70.31.2-2.5-3.8
Glucose1.01.67.8-0.8-0.8-0.40.0-0.02.8-0.5-1.7
Heart weight0.20.41.40.30.30.2-0.0-0.41.21.10.1
Delay discount hyperbolic model param1.11.32.1-1.1-1.1-1.2-1.30.5-1.4-0.5-1.4
Intermittent access intake day 1-15 change0.20.31.4-0.0-0.0-0.5-0.5-0.1-1.20.60.7
Intermittent access intake escalation0.10.21.1-0.1-0.1-0.4-0.4-0.1-1.00.40.6
Intermittent access intake escalation 20.10.10.2-0.1-0.1-0.4-0.5-0.1-0.40.50.3
Intermitt. access day 1 inactive lever presses0.20.62.2-0.1-0.1-1.0-0.70.70.21.01.5
Intermitt. access day 15 inactive lever presses0.40.92.00.80.81.11.1-1.4-1.1-0.20.3
Intermitt. access escalation Index0.30.51.90.40.4-0.8-0.70.6-1.40.4-0.1
Intermittent access day 1 total infusions1.01.62.91.71.71.51.5-1.60.0-0.7-0.3
Intermittent access day 15 total infusions0.61.02.01.11.10.70.8-1.4-1.4-0.3-0.0
Intermittent access terminal intake (last 3 days)1.11.43.01.31.31.21.2-1.7-0.6-1.1-0.7
Intermittent access total infusions1.51.83.61.61.61.51.4-1.9-1.3-0.7-0.2
Intermittent access day 1 locomotion1.82.33.51.81.81.91.8-1.80.5-1.0-0.1
Intermittent access day 15 total locomotion1.32.34.11.51.52.01.9-2.0-1.1-1.10.3
Intermittent access total locomotion1.92.34.11.91.91.81.7-2.0-0.6-0.40.5
Intermittent access standard deviation1.22.44.71.81.80.90.7-1.5-2.01.12.2
Left kidney weight0.94.37.8-2.6-2.6-2.6-2.81.8-0.41.0-1.5
Right kidney weight0.62.94.7-2.1-2.1-2.1-2.21.1-0.41.1-1.5
Cocaine induced anxiety3.65.231.8-1.5-1.5-1.2-1.20.3-5.6-1.1-0.8
Post-drug Anxiety2.32.416.9-0.6-0.6-0.7-0.60.2-4.1-0.90.2
Baseline Anxiety2.02.38.21.61.61.01.2-0.22.91.01.3
Tail length0.20.61.3-0.8-0.8-1.1-1.10.7-0.40.6-0.1
Length with tail0.94.07.7-1.9-1.9-2.8-2.72.0-1.21.90.2
Length without tail0.62.13.5-1.4-1.4-1.9-1.81.2-1.21.60.4
Times rat made contact with spout0.40.51.4-0.7-0.7-0.4-0.70.30.90.4-1.2
Lifetime Intake1.62.03.71.41.41.71.7-1.9-0.6-1.2-0.6
Liver weight, left3.66.010.7-2.7-2.7-3.3-3.13.1-0.51.90.4
Liver weight, right2.44.16.1-2.5-2.5-2.5-2.32.0-2.30.4-0.6
Locomotor activity3.04.78.5-2.9-2.9-1.1-1.31.9-2.8-2.1-1.2
Locomotor testing distance2.85.015.2-2.7-2.7-1.4-1.51.9-3.9-1.6-0.7
Locomotor testing rearing0.81.67.0-1.0-1.0-0.1-0.0-0.1-2.6-1.9-0.5
Locomotion in novel chamber0.30.41.1-0.6-0.6-0.5-0.60.5-1.10.8-0.3
Locomotion in novel chamber post-restriction0.10.10.40.10.10.40.6-0.20.6-0.20.2
Fecal boli incidents, locomotor time 10.10.10.4-0.2-0.20.20.30.30.7-0.00.2
Change in fecal boli incidents, locomotor task0.80.81.60.70.70.80.8-0.9-1.3-1.2-0.0
Time >=10cm from walls, locomotor time 10.90.91.80.70.71.11.2-1.30.9-0.8-0.9
Bouts of movement, locomotor time 10.70.82.2-0.3-0.3-0.4-0.80.8-0.21.41.5
Total resting periods, locomotor time 10.50.61.6-0.3-0.3-0.3-0.80.80.11.31.2
Rest time, locomotor task time 10.50.63.5-0.4-0.4-0.1-0.50.21.9-0.2-0.8
Distance moved, locomotor task time 10.20.21.00.30.3-0.10.00.3-1.00.40.7
Vertical activity count, locomotor time 10.20.40.70.80.80.40.5-0.20.10.70.8
Time >=10cm from walls, locomotor time 20.10.20.70.40.40.60.8-0.5-0.2-0.30.1
Bouts of movement, locomotor time 20.40.71.5-0.7-0.7-0.8-0.90.6-1.20.90.8
Total resting periods, locomotor time 20.50.91.2-1.0-1.0-1.0-1.10.8-1.10.90.6
Rest time, locomotor task time 20.70.86.1-0.1-0.10.0-0.10.12.5-0.0-0.7
Distance moved, locomotor task time 20.60.74.00.00.0-0.4-0.30.4-2.00.41.1
Vertical activity count, locomotor time 20.10.10.6-0.0-0.00.20.2-0.0-0.8-0.50.1
Light reinforcement 10.71.86.2-1.6-1.6-0.9-1.00.50.5-1.0-2.5
Light reinforcement 20.40.62.20.20.20.50.7-0.60.7-1.5-0.9
Bone: marrow area4.39.515.6-4.0-4.0-3.7-3.43.4-2.1-0.6-1.9
Bone: maximum diameter6.111.319.4-4.4-4.4-3.8-3.63.9-0.3-1.4-2.6
Bone: maximum force0.30.51.6-0.9-0.9-0.3-0.40.5-0.3-0.6-1.3
Bone: maximum moment0.40.71.8-1.0-1.0-0.4-0.50.7-0.6-0.6-1.3
Mean time between licks in bursts0.81.910.10.40.41.21.2-0.8-3.2-1.0-0.0
Mean num. licks in bursts0.91.52.6-1.0-1.0-1.3-1.51.2-1.61.20.6
Cd content in liver1.41.53.4-0.7-0.7-1.8-1.71.7-0.61.20.5
Co content in liver1.92.23.8-1.9-1.9-1.3-1.11.3-1.6-1.3-1.0
Cu content in liver1.11.35.51.31.30.40.50.1-0.80.72.4
Fe content in liver0.40.40.90.90.90.40.7-0.70.6-0.10.5
K content in liver1.00.92.90.90.90.2-0.1-0.3-0.61.61.7
Mg content in liver0.50.51.0-0.3-0.3-0.6-0.70.7-0.60.91.0
Mn content in liver3.23.511.12.22.20.50.6-0.10.02.73.3
Na content in liver2.22.311.3-0.7-0.7-1.2-1.31.0-3.40.71.4
Rb content in liver0.50.51.0-0.9-0.9-0.6-0.81.00.1-0.70.1
Se content in liver1.21.44.71.01.0-0.4-0.30.11.12.21.8
Sr content in liver0.20.20.60.70.7-0.1-0.00.50.00.30.2
Zn content in liver0.10.10.40.10.1-0.1-0.20.20.60.40.1
Bone: minimum diameter0.81.42.2-1.4-1.4-1.4-1.31.3-0.0-0.1-1.5
Time in familiar zone, hab. session 12.12.03.0-1.7-1.7-1.5-1.40.9-0.8-1.4-1.6
Time in novel zone, hab. session 10.80.81.81.11.10.70.7-0.50.31.30.9
Total zone transitions, hab. session 10.00.10.2-0.1-0.10.00.20.40.1-0.4-0.1
Total locomotion distance, hab. session 10.60.92.01.01.01.31.4-0.9-0.5-0.50.1
Locomotion velocity, hab. session 10.40.61.50.70.71.11.2-0.7-0.6-0.50.3
Time in familiar zone, hab. session 21.31.43.0-1.7-1.7-0.9-0.70.5-0.7-1.3-1.2
Time in novel zone, hab. session 20.50.51.01.01.00.60.5-0.10.60.70.7
Total zone transitions, hab. session 20.81.06.1-0.1-0.1-0.4-0.20.8-2.5-0.30.8
Total locomotion distance, hab. session 20.70.93.00.90.90.70.9-0.2-1.7-0.31.1
Locomotion velocity, hab. session 20.70.93.60.70.70.40.60.0-1.90.01.3
Novel to familiar place preference ratio1.41.55.90.90.90.60.3-0.2-2.40.91.9
Novelty place preference1.21.35.60.70.70.50.2-0.1-2.40.81.6
Time in novel zone, NPP test1.11.26.40.30.30.30.00.2-2.50.81.5
Total zone transitions, NPP test0.10.10.10.30.30.40.40.3-0.1-0.30.3
Total locomotion distance, NPP test0.50.71.21.11.10.90.9-0.4-0.2-0.11.1
Locomotion velocity, NPP test0.81.11.91.41.41.21.2-0.8-0.2-0.11.2
Intraocular pressure1.82.57.2-1.8-1.8-0.7-0.40.8-2.7-1.8-1.4
Delta distance traveled before/after self-admin1.41.55.70.00.01.31.1-0.80.2-2.4-1.7
Delta ambulatory time before/after self-admin0.91.24.1-0.2-0.21.00.8-0.70.6-2.0-1.6
Parametrial fat weight0.61.55.3-0.6-0.6-1.2-1.40.80.42.31.3
Pavlov. Cond. lever latency0.50.63.00.40.40.60.7-0.30.6-1.7-0.1
Pavlov. Cond. magazine entry latency1.31.62.6-1.2-1.2-1.6-1.61.6-1.20.9-0.0
Pavlov. Cond. change in total contacts1.11.22.3-0.9-0.9-1.2-1.41.0-1.51.0-0.2
Pavlov. Cond. index score1.01.21.9-1.1-1.1-1.3-1.41.2-0.91.1-0.3
Pavlov. Cond. latency score1.01.32.0-1.2-1.2-1.3-1.41.1-1.11.1-0.4
Pavlov. Cond. lever contacts0.91.13.6-0.8-0.8-1.1-1.20.7-0.81.90.0
Pavlov. Cond. magazine entry number0.60.81.30.60.61.11.1-1.11.1-0.9-0.0
Pavlov. Cond. intertrial magazine entries0.81.01.91.41.40.50.6-0.7-0.91.01.1
Pavlov. Cond. lever-magazine prob. diff.1.01.31.9-1.1-1.1-1.3-1.41.2-1.01.3-0.1
Pavlov. Cond. response bias0.50.62.0-0.4-0.4-0.9-0.90.6-0.71.40.1
Pavlov. Cond. lever latency1.41.93.61.01.01.71.8-1.60.9-1.9-0.8
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.4-0.1-0.10.20.3-0.4-0.5
Pavlov. Cond. change in total contacts0.50.92.8-0.2-0.2-0.8-0.90.7-1.71.00.9
Pavlov. Cond. index score0.81.01.7-0.9-0.9-1.3-1.31.2-1.00.90.4
Pavlov. Cond. latency score0.50.71.1-0.9-0.9-1.0-1.01.0-1.00.30.2
Pavlov. Cond. lever contacts1.82.44.2-1.3-1.3-2.0-2.01.8-1.01.90.6
Pavlov. Cond. magazine entry number0.40.51.20.90.90.40.5-0.5-0.20.81.1
Pavlov. Cond. intertrial magazine entries0.71.12.81.41.40.81.1-1.70.20.30.1
Pavlov. Cond. lever-magazine prob. diff.0.70.91.4-0.8-0.8-1.1-1.21.1-1.00.80.4
Pavlov. Cond. response bias1.11.54.5-0.7-0.7-1.5-1.61.3-0.42.10.8
Time in closed arm before self-admin0.10.10.5-0.1-0.1-0.4-0.30.30.2-0.7-0.5
Time in closed arm after self-admin0.10.10.40.00.0-0.6-0.30.0-0.10.1-0.2
Time in open arm before self-admin0.50.51.20.60.61.11.1-0.80.10.30.7
Time in open arm after self-admin0.20.20.80.30.30.90.7-0.30.3-0.10.4
Bone: periosteal estimation4.18.614.3-3.8-3.8-3.3-3.13.2-1.7-1.1-2.4
Bone: periosteal perimeter3.66.29.8-3.1-3.1-2.9-2.82.8-0.8-0.9-2.2
Bone: post-yield work0.50.81.7-1.2-1.2-0.6-0.61.30.3-0.5-0.8
Progressive ratio test 1 active lever presses1.31.62.41.51.51.41.3-1.61.0-0.8-0.4
Progressive ratio test 1 breakpoint1.21.42.31.51.51.31.2-1.50.9-0.7-0.3
Progressive ratio test 1 inactive lever presses1.82.55.52.32.31.71.6-1.70.50.41.0
Progressive ratio test 2 active lever presses1.41.74.71.61.61.21.4-2.20.2-0.2-0.2
Progressive ratio test 2 breakpoint1.51.74.71.51.51.31.4-2.20.3-0.3-0.4
Progressive ratio test 2 inactive lever presses1.11.84.01.91.91.11.1-2.0-0.6-0.30.0
Incentive Sensitization - Responses0.50.71.90.90.9-0.00.3-1.1-1.40.80.4
Incentive Sensitization - Breakpoint0.60.71.70.90.90.10.3-1.2-1.30.90.5
Sum of active levers in priming session hrs 5-60.20.20.30.40.40.50.5-0.4-0.2-0.50.2
Progressive ratio0.60.93.2-0.9-0.9-0.7-0.70.8-1.8-0.5-0.5
Food seeking constrained by brief footshock0.20.20.6-0.1-0.10.10.4-0.4-0.6-0.8-0.5
Seeking ratio, punishment vs. effort1.01.53.01.21.21.31.5-1.51.7-0.10.2
Retroperitoneal fat weight0.52.07.91.01.00.0-0.0-0.72.82.11.1
Reaction time number correct5.911.320.8-4.1-4.1-4.6-4.33.8-0.30.5-1.9
Reaction time mean minus median0.20.63.90.30.3-0.1-0.40.22.00.60.4
Reaction time mean minus median AUC0.41.15.90.70.70.1-0.1-0.02.41.00.7
Reaction time num false alarms1.01.43.1-0.4-0.4-1.3-1.41.3-1.81.21.0
Reaction time num false alarms AUC1.32.04.3-0.7-0.7-1.6-1.71.5-2.11.50.8
Reaction time trials correct on left5.911.320.8-4.1-4.1-4.6-4.33.8-0.30.5-1.9
Reaction time trials on left5.911.120.5-4.0-4.0-4.5-4.33.7-0.20.5-1.9
Reaction time mean1.42.34.91.41.41.81.5-1.72.2-1.0-0.4
Reaction time mean AUC1.11.84.61.01.01.51.3-1.42.1-1.2-0.7
Median of all reaction times2.02.84.41.71.72.11.9-2.11.5-1.5-0.6
Reaction time omissions0.40.53.30.50.50.30.2-0.31.80.20.4
Reaction time false alarm rate1.31.83.11.61.61.00.8-0.7-1.51.21.8
Reaction time premature initiation rate0.10.20.40.40.40.40.4-0.2-0.3-0.6-0.4
Reaction time premature initiations1.01.93.4-1.5-1.5-1.8-1.71.6-0.3-0.3-1.3
Std. dev. reaction times1.32.313.11.31.30.90.5-0.73.60.70.5
Reaction time trials completed5.911.120.5-4.0-4.0-4.5-4.33.7-0.20.5-1.9
Reaction time trials AUC5.710.920.5-4.0-4.0-4.5-4.33.7-0.20.7-1.7
Run reversals in cocaine runway, females1.61.65.8-0.2-0.21.21.1-0.8-0.4-2.4-1.9
Run reversals in cocaine runway, males0.80.81.61.01.01.31.2-1.00.30.30.4
Latency to leave start box in cocaine runway0.40.51.2-0.8-0.8-0.4-0.40.71.1-0.7-0.3
Latency to leave start box in cocaine runway, F0.91.01.5-1.2-1.2-1.0-1.01.00.4-0.9-1.0
Latency to leave start box in cocaine runway, M1.41.32.91.11.11.31.5-0.71.7-0.10.9
Std. dev. time between licks in bursts0.40.62.0-0.7-0.70.20.50.2-1.4-1.2-0.1
Total sessions with >9 infusions3.84.67.42.22.22.62.7-2.62.1-1.4-0.6
Short access day 1 total inactive lever presses0.60.82.01.11.10.81.0-1.4-0.4-0.3-0.1
Short access day 10 total inactive lever presses0.20.41.20.70.7-0.00.2-0.4-0.20.81.1
Short access day 1 total infusions2.73.55.62.02.02.12.4-2.02.2-1.0-0.3
Short access day 10 total infusions0.91.12.31.11.11.51.4-1.00.2-1.10.1
Short access total infusions3.34.27.52.12.12.62.7-2.41.2-1.7-0.6
Short access day 1 locomotion1.82.28.31.21.21.51.4-1.02.9-1.0-0.6
Short access day 10 total locomotion0.71.34.31.21.20.70.6-0.40.81.12.1
Short access total locomotion3.64.46.62.62.62.52.4-2.12.1-0.41.0
One hour access (0.3 mA shock)1.11.22.81.71.70.81.0-0.90.11.01.0
Compulsive drug intake3.84.612.6-0.5-0.5-2.8-2.62.30.73.51.7
One hour access (shock baseline)1.42.23.81.41.41.92.0-1.9-0.9-1.2-0.4
Social response proportion0.50.61.8-0.7-0.7-0.3-0.40.3-0.5-1.2-1.3
Social responses0.60.73.1-0.6-0.60.20.10.50.3-1.8-1.2
Social time0.20.21.10.30.3-0.10.1-0.10.4-0.6-1.0
Soleus weight5.917.326.4-5.0-5.0-4.5-4.45.1-4.7-0.10.4
Bone: stiffness0.40.71.5-1.2-1.2-0.4-0.60.9-0.4-0.7-1.0
Tibialis anterior weight3.812.922.3-3.8-3.8-4.7-4.74.2-2.22.4-0.9
Time to tail flick, vehicle, before self-admin0.20.20.40.20.20.40.4-0.6-0.2-0.6-0.5
Time to tail flick, vehicle, after self-admin0.40.51.10.60.60.50.7-1.1-0.9-0.5-0.7
Time to tail flick, test, before self-admin0.10.10.3-0.2-0.2-0.00.3-0.50.2-0.4-0.1
Time to tail flick, test, after self-admin0.20.31.1-0.2-0.2-0.1-0.20.4-0.10.81.1
Delta time to tail flick, vehicle, before/after SA0.50.51.10.90.90.70.8-1.0-0.10.10.0
Delta time to tail flick, test, before/after SA0.40.41.10.60.60.30.00.40.21.11.1
Tibia length2.36.310.5-3.0-3.0-3.2-3.22.7-1.11.0-1.5
Ambulatory time before self-admin0.81.24.50.30.3-0.7-0.60.6-0.81.82.1
Ambulatory time after self-admin0.10.10.40.00.00.30.10.00.2-0.30.6
Bone: tissue strength0.60.63.50.00.0-0.1-0.40.5-1.90.70.4
Total heroin consumption0.20.20.7-0.3-0.30.50.20.10.6-0.8-0.6
Bone: trabecular number1.82.95.5-2.1-2.1-2.3-2.21.9-0.10.4-0.9
Bone: trabecular spacing0.60.83.30.70.70.10.2-0.0-1.80.51.2
Bone: trabecular thickness0.40.52.8-0.2-0.2-0.3-0.50.11.70.8-0.3
Bone: trabecular tissue density0.10.10.4-0.3-0.3-0.3-0.10.1-0.6-0.0-0.1
Water consumed over 24 hours3.04.17.2-2.7-2.7-1.9-2.11.51.70.0-2.2
Number of responses in last shaping day7.58.212.83.33.33.63.6-3.42.5-0.50.6